John Chang

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-0873-6218 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityBS1995Biological Sciences Medicine
    NIH, BethesdaResearch Scholar1999HHMI-NIH
    Temple UniversityMD2001Medicine
    University of PennsylvaniaInternship / Residency2004Internal Medicine
    University of PennsylvaniaFellowship2007Gastroenterology
    University of PennsylvaniaPostdoctoral2009Immunology

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Transcriptional regulation of T cell immunity
    NIH I01BX005106Apr 1, 2021 - Mar 31, 2025
    Role: Principal Investigator
    Using single-cell approaches to study inflammatory bowel disease
    NIH R21DK119724Aug 10, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Role of proteasome activity in adaptive immunity
    NIH R01AI129973Dec 1, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Interrogating adaptive immunity to microbial infection
    NIH I01BX003424Oct 1, 2016 - Sep 30, 2020
    Role: Principal Investigator
    Using single-cell RNA-seq to interrogate host immunity to pathogens
    NIH R01AI123202Sep 23, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Role of atypical Protein Kinase C in Inflammatory Bowel Disease
    NIH R01DK093507Apr 1, 2012 - Mar 31, 2018
    Role: Principal Investigator
    Modulating the Proteasome in Inflammatory Bowel Disease
    NIH R03DK093593Mar 2, 2012 - Feb 28, 2014
    Role: Principal Investigator
    Regulation and Function of Polarity and Asymmetric Cell Division in Immunity
    NIH R01AI095277Dec 1, 2011 - Nov 30, 2016
    Role: Principal Investigator
    Understanding the Basis for Cellular Diversity During Adaptive Immunity
    NIH DP2OD008469Sep 30, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Asymmetric T cell division initiating adaptive immunity and colitis
    NIH K08DK080949Jul 1, 2008 - Jun 30, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted. bioRxiv. 2024 Mar 25. Reina-Campos M, Monell A, Ferry A, Luna V, Cheung KP, Galletti G, Scharping NE, Takehara KK, Quon S, Boland B, Lin YH, Wong WH, Indralingam CS, Yeo GW, Chang JT, Heeg M, Goldrath AW. PMID: 38585842; PMCID: PMC10996520.
      View in: PubMed   Mentions:
    2. Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity. Nat Immunol. 2023 Dec; 24(12):2108-2120. Lin CH, Wu CJ, Cho S, Patkar R, Huth WJ, Lin LL, Chen MC, Israelsson E, Betts J, Niedzielska M, Patel SA, Duong HG, Gerner RR, Hsu CY, Catley M, Maciewicz RA, Chu H, Raffatellu M, Chang JT, Lu LF. PMID: 37932457.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Responsiveness to Vedolizumab Therapy in Ulcerative Colitis is Associated With Alterations in Immune Cell-Cell Communications. Inflamm Bowel Dis. 2023 10 03; 29(10):1602-1612. Hsu P, Choi EJ, Patel SA, Wong WH, Olvera JG, Yao P, Liu YC, Tsai MS, Wang W, Boland BS, Chang JT. PMID: 37235748; PMCID: PMC10547234.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Metabolic programs of T cell tissue residency empower tumour immunity. Nature. 2023 Sep; 621(7977):179-187. Reina-Campos M, Heeg M, Kennewick K, Mathews IT, Galletti G, Luna V, Nguyen Q, Huang H, Milner JJ, Hu KH, Vichaidit A, Santillano N, Boland BS, Chang JT, Jain M, Sharma S, Krummel MF, Chi H, Bensinger SJ, Goldrath AW. PMID: 37648857.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    5. IL-2 can signal via chemokine receptors to promote regulatory T cells' suppressive function. Cell Rep. 2023 08 29; 42(8):112996. Sun H, Lee HS, Kim SH, Fernandes de Lima M, Gingras AR, Du Q, McLaughlin W, Ablack J, Lopez-Ramirez MA, Lagarrigue F, Fan Z, Chang JT, VanDyke D, Spangler JB, Ginsberg MH. PMID: 37598341; PMCID: PMC10564087.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. A regulatory circuit controlled by extranuclear and nuclear retinoic acid receptor α determines T cell activation and function. Immunity. 2023 09 12; 56(9):2054-2069.e10. Larange A, Takazawa I, Kakugawa K, Thiault N, Ngoi S, Olive ME, Iwaya H, Seguin L, Vicente-Suarez I, Becart S, Verstichel G, Balancio A, Altman A, Chang JT, Taniuchi I, Lillemeier B, Kronenberg M, Myers SA, Cheroutre H. PMID: 37597518; PMCID: PMC10552917.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5. J Immunol. 2023 07 15; 211(2):241-251. Louis TL, Wong WH, Yao P, Kurd NS, Tysl T, Indralingam CS, Ma S, Huang WJM, Chang JT. PMID: 37265401; PMCID: PMC10373580.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Identification of CD8 + T-Cell-Immune Cell Communications in Ileal Crohn's Disease. Clin Transl Gastroenterol. 2023 05 01; 14(5):e00576. Duong HG, Choi EJ, Hsu P, Chiang NR, Patel SA, Olvera JG, Liu YC, Lin YH, Yao P, Wong WH, Indralingam CS, Tsai MS, Boland BS, Wang W, Chang JT. PMID: 36854061; PMCID: PMC10208704.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity. bioRxiv. 2023 Feb 21. Lin CH, Wu CJ, Cho S, Patkar R, Lin LL, Chen MC, Israelsson E, Betts J, Niedzielska M, Patel SA, Duong HG, Gerner RR, Hsu CY, Catley M, Maciewicz RA, Chu H, Raffatellu M, Chang JT, Lu LF. PMID: 36865314; PMCID: PMC9980002.
      View in: PubMed   Mentions:
    10. Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection. PLoS Biol. 2023 01; 21(1):e3001983. Quezada LK, Jin W, Liu YC, Kim ES, He Z, Indralingam CS, Tysl T, Labarta-Bajo L, Wehrens EJ, Jo Y, Kazane KR, Hattori C, Zuniga EI, Yeo GW, Chang JT. PMID: 36716323; PMCID: PMC9886247.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy. Sci Adv. 2023 01 20; 9(3):eadd1166. Mayer AT, Holman DR, Sood A, Tandon U, Bhate SS, Bodapati S, Barlow GL, Chang J, Black S, Crenshaw EC, Koron AN, Streett SE, Gambhir SS, Sandborn WJ, Boland BS, Hastie T, Tibshirani R, Chang JT, Nolan GP, Schürch CM, Rogalla S. PMID: 36662860; PMCID: PMC9858501.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    12. Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes. Immunity. 2023 01 10; 56(1):207-223.e8. Lin YH, Duong HG, Limary AE, Kim ES, Hsu P, Patel SA, Wong WH, Indralingam CS, Liu YC, Yao P, Chiang NR, Vandenburgh SA, Anderson TR, Olvera JG, Ferry A, Takehara KK, Jin W, Tsai MS, Yeo GW, Goldrath AW, Chang JT. PMID: 36580919; PMCID: PMC9904390.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    13. Systems-level identification of key transcription factors in immune cell specification. PLoS Comput Biol. 2022 09; 18(9):e1010116. Liu C, Omilusik K, Toma C, Kurd NS, Chang JT, Goldrath AW, Wang W. PMID: 36156073; PMCID: PMC9536753.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    14. Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments. Nat Immunol. 2022 07; 23(7):1121-1131. Crowl JT, Heeg M, Ferry A, Milner JJ, Omilusik KD, Toma C, He Z, Chang JT, Goldrath AW. PMID: 35761084; PMCID: PMC10041538.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    15. The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression. J Exp Med. 2022 06 06; 219(6). Kanbar JN, Ma S, Kim ES, Kurd NS, Tsai MS, Tysl T, Widjaja CE, Limary AE, Yee B, He Z, Hao Y, Fu XD, Yeo GW, Huang WJ, Chang JT. PMID: 35593887; PMCID: PMC9127983.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    16. Preserved SARS-CoV-2 Vaccine Cell-Mediated Immunogenicity in Patients With Inflammatory Bowel Disease on Immune-Modulating Therapies. Clin Transl Gastroenterol. 2022 04 01; 13(4):e00484. Boland BS, Goodwin B, Zhang Z, Bloom N, Kato Y, Neill J, Le H, Tysl T, Collins AE, Dulai PS, Singh S, Nguyen NH, Grifoni A, Sette A, Weiskopf D, Chang JT, Dan JM. PMID: 35347100; PMCID: PMC9038482.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients. Cell Mol Gastroenterol Hepatol. 2022; 14(1):35-53. Gonzalez CG, Mills RH, Kordahi MC, Carrillo-Terrazas M, Secaira-Morocho H, Widjaja CE, Tsai MS, Mittal Y, Yee BA, Vargas F, Weldon K, Gauglitz JM, Delaroque C, Sauceda C, Rossitto LA, Ackermann G, Humphrey G, Swafford AD, Siegel CA, Buckey JC, Raffals LE, Sadler C, Lindholm P, Fisch KM, Valaseck M, Suriawinata A, Yeo GW, Ghosh P, Chang JT, Chu H, Dorrestein P, Zhu Q, Chassaing B, Knight R, Gonzalez DJ, Dulai PS. PMID: 35378331; PMCID: PMC9117812.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    18. RORγt phosphorylation protects against T cell-mediated inflammation. Cell Rep. 2022 03 15; 38(11):110520. Ma S, Patel SA, Abe Y, Chen N, Patel PR, Cho BS, Abbasi N, Zeng S, Schnabl B, Chang JT, Huang WJM. PMID: 35294872; PMCID: PMC8982147.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    19. Skin inflammation activates intestinal stromal fibroblasts and promotes colitis. J Clin Invest. 2021 11 01; 131(21). Dokoshi T, Seidman JS, Cavagnero KJ, Li F, Liggins MC, Taylor BC, Olvera J, Knight R, Chang JT, Salzman NH, Gallo RL. PMID: 34720087; PMCID: PMC8553570.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    20. Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease. Nat Commun. 2021 07 12; 12(1):4246. Sahoo D, Swanson L, Sayed IM, Katkar GD, Ibeawuchi SR, Mittal Y, Pranadinata RF, Tindle C, Fuller M, Stec DL, Chang JT, Sandborn WJ, Das S, Ghosh P. PMID: 34253728; PMCID: PMC8275683.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    21. Gastrointestinal Surgery for Inflammatory Bowel Disease Persistently Lowers Microbiome and Metabolome Diversity. Inflamm Bowel Dis. 2021 04 15; 27(5):603-616. Fang X, Vázquez-Baeza Y, Elijah E, Vargas F, Ackermann G, Humphrey G, Lau R, Weldon KC, Sanders JG, Panitchpakdi M, Carpenter C, Jarmusch AK, Neill J, Miralles A, Dulai P, Singh S, Tsai M, Swafford AD, Smarr L, Boyle DL, Palsson BO, Chang JT, Dorrestein PC, Sandborn WJ, Knight R, Boland BS. PMID: 33026068; PMCID: PMC8047854.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    22. Pathophysiology of Inflammatory Bowel Diseases. Reply. N Engl J Med. 2021 04 08; 384(14):1378. Chang JT. PMID: 33826833.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Distinct integrin activation pathways for effector and regulatory T cell trafficking and function. J Exp Med. 2021 02 01; 218(2). Sun H, Lagarrigue F, Wang H, Fan Z, Lopez-Ramirez MA, Chang JT, Ginsberg MH. PMID: 33104169; PMCID: PMC7590511.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    24. Clone Wars: Survival of the Fittest CD8+ Trm Cells. Immunity. 2021 01 12; 54(1):4-6. Louis TL, Chang JT. PMID: 33440136.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    25. Pathophysiology of Inflammatory Bowel Diseases. N Engl J Med. 2020 Dec 31; 383(27):2652-2664. Chang JT. PMID: 33382932.
      View in: PubMed   Mentions: 268     Fields:    Translation:HumansCells
    26. Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25667-25678. Milner JJ, Nguyen H, Omilusik K, Reina-Campos M, Tsai M, Toma C, Delpoux A, Boland BS, Hedrick SM, Chang JT, Goldrath AW. PMID: 32978300; PMCID: PMC7568335.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    27. Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses. Sci Immunol. 2020 08 21; 5(50). Boland BS, He Z, Tsai MS, Olvera JG, Omilusik KD, Duong HG, Kim ES, Limary AE, Jin W, Milner JJ, Yu B, Patel SA, Louis TL, Tysl T, Kurd NS, Bortnick A, Quezada LK, Kanbar JN, Miralles A, Huylebroeck D, Valasek MA, Dulai PS, Singh S, Lu LF, Bui JD, Murre C, Sandborn WJ, Goldrath AW, Yeo GW, Chang JT. PMID: 32826341; PMCID: PMC7733868.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    28. Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy. Immunity. 2020 05 19; 52(5):808-824.e7. Milner JJ, Toma C, He Z, Kurd NS, Nguyen QP, McDonald B, Quezada L, Widjaja CE, Witherden DA, Crowl JT, Shaw LA, Yeo GW, Chang JT, Omilusik KD, Goldrath AW. PMID: 32433949; PMCID: PMC7784612.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    29. Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing. Sci Immunol. 2020 05 15; 5(47). Kurd NS, He Z, Louis TL, Milner JJ, Omilusik KD, Jin W, Tsai MS, Widjaja CE, Kanbar JN, Olvera JG, Tysl T, Quezada LK, Boland BS, Huang WJ, Murre C, Goldrath AW, Yeo GW, Chang JT. PMID: 32414833; PMCID: PMC7341730.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    30. Global chemical effects of the microbiome include new bile-acid conjugations. Nature. 2020 03; 579(7797):123-129. Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. PMID: 32103176; PMCID: PMC7252668.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimals
    31. Development and Validation of Clinical Scoring Tool to Predict Outcomes of Treatment With Vedolizumab in Patients With Ulcerative Colitis. Clin Gastroenterol Hepatol. 2020 12; 18(13):2952-2961.e8. Dulai PS, Singh S, Vande Casteele N, Meserve J, Winters A, Chablaney S, Aniwan S, Shashi P, Kochhar G, Weiss A, Koliani-Pace JL, Gao Y, Boland BS, Chang JT, Faleck D, Hirten R, Ungaro R, Lukin D, Sultan K, Hudesman D, Chang S, Bohm M, Varma S, Fischer M, Shmidt E, Swaminath A, Gupta N, Rosario M, Jairath V, Guizzetti L, Feagan BG, Siegel CA, Shen B, Kane S, Loftus EV, Sandborn WJ, Sands BE, Colombel JF, Lasch K, Cao C. PMID: 32062041; PMCID: PMC7899124.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    32. Optimizing sequencing protocols for leaderboard metagenomics by combining long and short reads. Genome Biol. 2019 10 31; 20(1):226. Sanders JG, Nurk S, Salido RA, Minich J, Xu ZZ, Zhu Q, Martino C, Fedarko M, Arthur TD, Chen F, Boland BS, Humphrey GC, Brennan C, Sanders K, Gaffney J, Jepsen K, Khosroheidari M, Green C, Liyanage M, Dang JW, Phelan VV, Quinn RA, Bankevich A, Chang JT, Rana TM, Conrad DJ, Sandborn WJ, Smarr L, Dorrestein PC, Pevzner PA, Knight R. PMID: 31672156; PMCID: PMC6822431.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    33. The Autoimmune Protocol Diet Modifies Intestinal RNA Expression in Inflammatory Bowel Disease. Crohns Colitis 360. 2019 Oct; 1(3):otz016. Chandrasekaran A, Molparia B, Akhtar E, Wang X, Lewis JD, Chang JT, Oliveira G, Torkamani A, Konijeti GG. PMID: 32309803; PMCID: PMC7147823.
      View in: PubMed   Mentions: 2  
    34. Should We Divide Crohn's Disease Into Ileum-Dominant and Isolated Colonic Diseases? Clin Gastroenterol Hepatol. 2019 12; 17(13):2634-2643. Dulai PS, Singh S, Vande Casteele N, Boland BS, Rivera-Nieves J, Ernst PB, Eckmann L, Barrett KE, Chang JT, Sandborn WJ. PMID: 31009791; PMCID: PMC6885453.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    35. Biomarkers Are Associated With Clinical and Endoscopic Outcomes With Vedolizumab Treatment in Ulcerative Colitis. Inflamm Bowel Dis. 2019 01 10; 25(2):410-420. Battat R, Dulai PS, Vande Casteele N, Evans E, Hester KD, Webster E, Jain A, Proudfoot JA, Mairalles A, Neill J, Singh S, Chang JT, Rivera-Nieves J, Sandborn WJ, Boland BS. PMID: 30295781; PMCID: PMC6327228.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    36. Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9192-E9200. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. PMID: 30209212; PMCID: PMC6166836.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    37. Development and Validation of a Scoring System to Predict Outcomes of Vedolizumab Treatment in Patients With Crohn's Disease. Gastroenterology. 2018 09; 155(3):687-695.e10. Dulai PS, Boland BS, Singh S, Chaudrey K, Koliani-Pace JL, Kochhar G, Parikh MP, Shmidt E, Hartke J, Chilukuri P, Meserve J, Whitehead D, Hirten R, Winters AC, Katta LG, Peerani F, Narula N, Sultan K, Swaminath A, Bohm M, Lukin D, Hudesman D, Chang JT, Rivera-Nieves J, Jairath V, Zou GY, Feagan BG, Shen B, Siegel CA, Loftus EV, Kane S, Sands BE, Colombel JF, Sandborn WJ, Lasch K, Cao C. PMID: 29857091; PMCID: PMC6419724.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    38. USP11 Enhances TGFβ-Induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis. Mol Cancer Res. 2018 07; 16(7):1172-1184. Garcia DA, Baek C, Estrada MV, Tysl T, Bennett EJ, Yang J, Chang JT. PMID: 29724812; PMCID: PMC6030438.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    39. Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. J Immunol. 2018 06 15; 200(12):4012-4023. Klann JE, Kim SH, Remedios KA, He Z, Metz PJ, Lopez J, Tysl T, Olvera JG, Ablack JN, Cantor JM, Boland BS, Yeo G, Zheng Y, Lu LF, Bui JD, Ginsberg MH, Petrich BG, Chang JT. PMID: 29703862; PMCID: PMC5988969.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    40. Hyperbaric oxygen therapy is well tolerated and effective for ulcerative colitis patients hospitalized for moderate-severe flares: a phase 2A pilot multi-center, randomized, double-blind, sham-controlled trial. Am J Gastroenterol. 2018 10; 113(10):1516-1523. Dulai PS, Buckey JC, Raffals LE, Swoger JM, Claus PL, O'Toole K, Ptak JA, Gleeson MW, Widjaja CE, Chang JT, Adler JM, Patel N, Skinner LA, Haren SP, Goldby-Reffner K, Thompson KD, Siegel CA. PMID: 29453383.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    41. Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease. Clin Transl Gastroenterol. 2018 Jan 18; 9(1):e132. Moustafa A, Li W, Anderson EL, Wong EHM, Dulai PS, Sandborn WJ, Biggs W, Yooseph S, Jones MB, Venter JC, Nelson KE, Chang JT, Telenti A, Boland BS. PMID: 29345635; PMCID: PMC5795019.
      View in: PubMed   Mentions: 49     Fields:    
    42. Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. J Clin Invest. 2017 Oct 02; 127(10):3609-3623. Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR, Goldrath AW, Overkleeft HS, Ovaa H, Chang JT. PMID: 28846070; PMCID: PMC5617668.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    43. Erratum: Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation. Nat Immunol. 2017 05 18; 18(6):705. Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW. PMID: 28518161.
      View in: PubMed   Mentions: 10     Fields:    
    44. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. J Immunol. 2017 06 15; 198(12):4639-4651. Klann JE, Remedios KA, Kim SH, Metz PJ, Lopez J, Mack LA, Zheng Y, Ginsberg MH, Petrich BG, Chang JT. PMID: 28515282; PMCID: PMC5507362.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    45. Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation. Nat Immunol. 2017 05; 18(5):573-582. Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW. PMID: 28288100; PMCID: PMC5395420.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    46. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing. Nat Immunol. 2017 04; 18(4):422-432. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga EI, Goldrath AW, Chang JT, Yeo GW. PMID: 28218746; PMCID: PMC5360497.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    47. The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1. Gut. 2017 09; 66(9):1584-1596. Bertin S, Aoki-Nonaka Y, Lee J, de Jong PR, Kim P, Han T, Yu T, To K, Takahashi N, Boland BS, Chang JT, Ho SB, Herdman S, Corr M, Franco A, Sharma S, Dong H, Akopian AN, Raz E. PMID: 27325418; PMCID: PMC5173457.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    48. The Real-World Effectiveness and Safety of Vedolizumab for Moderate-Severe Crohn's Disease: Results From the US VICTORY Consortium. Am J Gastroenterol. 2016 08; 111(8):1147-55. Dulai PS, Singh S, Jiang X, Peerani F, Narula N, Chaudrey K, Whitehead D, Hudesman D, Lukin D, Swaminath A, Shmidt E, Wang S, Boland BS, Chang JT, Kane S, Siegel CA, Loftus EV, Sandborn WJ, Sands BE, Colombel JF. PMID: 27296941.
      View in: PubMed   Mentions: 111     Fields:    Translation:Humans
    49. Cronkhite Canada Syndrome: Significant Response to Infliximab and a Possible Clue to Pathogenesis. Am J Gastroenterol. 2016 05; 111(5):746-8. Boland BS, Bagi P, Valasek MA, Chang JT, Bustamante R, Madlensky L, Sandborn WJ, Harismendy O, Gupta S. PMID: 27151126; PMCID: PMC5824983.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    50. Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. Oncotarget. 2016 Apr 19; 7(16):21527-41. Banno A, Garcia DA, van Baarsel ED, Metz PJ, Fisch K, Widjaja CE, Kim SH, Lopez J, Chang AN, Geurink PP, Florea BI, Overkleeft HS, Ovaa H, Bui JD, Yang J, Chang JT. PMID: 26930717; PMCID: PMC5008303.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    51. The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation. J Immunol. 2016 05 15; 196(10):4237-45. Ngoi SM, Lopez JM, Chang JT. PMID: 27029586; PMCID: PMC4868634.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    52. Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates. Sci Rep. 2016 Jan 14; 6:19182. Metz PJ, Lopez J, Kim SH, Akimoto K, Ohno S, Chang JT. PMID: 26765121; PMCID: PMC4725917.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    53. Ubiquitylation of CD98 limits cell proliferation and clonal expansion. J Cell Sci. 2015 Dec 01; 128(23):4273-8. Ablack JN, Metz PJ, Chang JT, Cantor JM, Ginsberg MH. PMID: 26493331; PMCID: PMC4712820.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    54. Asymmetric Cell Division in T Lymphocyte Fate Diversification. Trends Immunol. 2015 Nov; 36(11):670-683. Arsenio J, Metz PJ, Chang JT. PMID: 26474675; PMCID: PMC4640954.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    55. Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide. Nat Commun. 2015 Oct 13; 6:8369. Corriden R, Hollands A, Olson J, Derieux J, Lopez J, Chang JT, Gonzalez DJ, Nizet V. PMID: 26458291; PMCID: PMC4610010.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    56. Reply to: "CD8(+) T cell diversification by asymmetric cell division". Nat Immunol. 2015 Sep; 16(9):893-4. Arsenio J, Kakaradov B, Metz PJ, Yeo GW, Chang JT. PMID: 26287585; PMCID: PMC4758127.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    57. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. PMID: 25731159; PMCID: PMC4447318.
      View in: PubMed   Mentions: 322     Fields:    Translation:HumansAnimalsCells
    58. Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency. J Immunol. 2015 Mar 15; 194(6):2551-60. Boland BS, Widjaja CE, Banno A, Zhang B, Kim SH, Stoven S, Peterson MR, Jones MC, Su HI, Crowe SE, Bui JD, Ho SB, Okugawa Y, Goel A, Marietta EV, Khosroheidari M, Jepsen K, Aramburu J, López-Rodríguez C, Sandborn WJ, Murray JA, Harismendy O, Chang JT. PMID: 25667416; PMCID: PMC4355235.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    59. Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease. Inflamm Bowel Dis. 2015 Feb; 21(2):323-30. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT. PMID: 25545378; PMCID: PMC4404151.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    60. Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι. J Immunol. 2015 Mar 01; 194(5):2249-59. Metz PJ, Arsenio J, Kakaradov B, Kim SH, Remedios KA, Oakley K, Akimoto K, Ohno S, Yeo GW, Chang JT. PMID: 25617472; PMCID: PMC4340726.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    61. Molecular regulation of effector and memory T cell differentiation. Nat Immunol. 2014 Dec; 15(12):1104-15. Chang JT, Wherry EJ, Goldrath AW. PMID: 25396352; PMCID: PMC4386685.
      View in: PubMed   Mentions: 280     Fields:    Translation:HumansAnimalsCells
    62. Algal chloroplast produced camelid VH H antitoxins are capable of neutralizing botulinum neurotoxin. Plant Biotechnol J. 2015 Jan; 13(1):117-24. Barrera DJ, Rosenberg JN, Chiu JG, Chang YN, Debatis M, Ngoi SM, Chang JT, Shoemaker CB, Oyler GA, Mayfield SP. PMID: 25229405; PMCID: PMC4620920.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    63. Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis. Aliment Pharmacol Ther. 2014 Sep; 40(5):477-85. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT. PMID: 25041724; PMCID: PMC4143528.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    64. Update on Janus kinase antagonists in inflammatory bowel disease. Gastroenterol Clin North Am. 2014 Sep; 43(3):603-17. Boland BS, Sandborn WJ, Chang JT. PMID: 25110261; PMCID: PMC4129380.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    65. Studies in human intestinal tissues: is it time to reemphasize research in human immunology? Gastroenterology. 2014 Jul; 147(1):26-30. Chang JT, Sandborn WJ, Ernst PB. PMID: 24877864.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    66. Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays. PLoS One. 2014; 9(3):e91926. Jung HR, Song KH, Chang JT, Doh J. PMID: 24632942; PMCID: PMC3954838.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    67. Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses. Nat Immunol. 2014 Apr; 15(4):365-372. Arsenio J, Kakaradov B, Metz PJ, Kim SH, Yeo GW, Chang JT. PMID: 24584088; PMCID: PMC3968536.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    68. Endoscopic retrieval of ingested nails using a refrigerator magnet. Clin Gastroenterol Hepatol. 2013 Sep; 11(9):A24. Kwong WT, Chang JT. PMID: 23333705.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    69. Strategies for the care of adults hospitalized for active ulcerative colitis. Clin Gastroenterol Hepatol. 2012 Dec; 10(12):1315-1325.e4. Pola S, Patel D, Ramamoorthy S, McLemore E, Fahmy M, Rivera-Nieves J, Chang JT, Evans E, Docherty M, Talamini M, Sandborn WJ. PMID: 22835577; PMCID: PMC4226798.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    70. Polarity and lymphocyte fate determination. Curr Opin Cell Biol. 2012 Aug; 24(4):526-33. Chang JT. PMID: 22658837; PMCID: PMC3425726.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    71. Cutting edge: Asymmetric memory T cell division in response to rechallenge. J Immunol. 2012 May 01; 188(9):4145-8. Ciocca ML, Barnett BE, Burkhardt JK, Chang JT, Reiner SL. PMID: 22467651; PMCID: PMC3331961.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    72. Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity. J Immunol. 2011 Jul 15; 187(2):851-60. Cantor J, Slepak M, Ege N, Chang JT, Ginsberg MH. PMID: 21670318; PMCID: PMC3131465.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    73. Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity. 2011 Apr 22; 34(4):492-504. Chang JT, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, Koretzky GA, Jordan MS, Reiner SL. PMID: 21497118; PMCID: PMC3088519.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    74. Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms. J Immunol. 2010 Jul 01; 185(1):367-75. Oliaro J, Van Ham V, Sacirbegovic F, Pasam A, Bomzon Z, Pham K, Ludford-Menting MJ, Waterhouse NJ, Bots M, Hawkins ED, Watt SV, Cluse LA, Clarke CJ, Izon DJ, Chang JT, Thompson N, Gu M, Johnstone RW, Smyth MJ, Humbert PO, Reiner SL, Russell SM. PMID: 20530266; PMCID: PMC3739982.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    75. Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation. J Immunol. 2009 Apr 15; 182(8):4686-95. Kambayashi T, Allenspach EJ, Chang JT, Zou T, Shoag JE, Reiner SL, Caton AJ, Koretzky GA. PMID: 19342644; PMCID: PMC2922395.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    76. Asymmetric division and stem cell renewal without a permanent niche: lessons from lymphocytes. Cold Spring Harb Symp Quant Biol. 2008; 73:73-9. Chang JT, Reiner SL. PMID: 19022740.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    77. Specifying helper T cell fates during immunity. J Pediatr Gastroenterol Nutr. 2008 Apr; 46 Suppl 1:E19-20. Chang JT, Reiner SL. PMID: 18354322.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    78. Protection one cell thick. Immunity. 2007 Dec; 27(6):832-4. Chang JT, Reiner SL. PMID: 18093536.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    79. Quality indicators for falls and mobility problems in vulnerable elders. J Am Geriatr Soc. 2007 Oct; 55 Suppl 2:S327-34. Chang JT, Ganz DA. PMID: 17910554.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    80. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science. 2007 Mar 23; 315(5819):1687-91. Chang JT, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, Banerjee A, Longworth SA, Vinup KE, Mrass P, Oliaro J, Killeen N, Orange JS, Russell SM, Weninger W, Reiner SL. PMID: 17332376.
      View in: PubMed   Mentions: 431     Fields:    Translation:AnimalsCells
    81. The effect of a quality improvement initiative on the quality of other aspects of health care: the law of unintended consequences? Med Care. 2007 Jan; 45(1):8-18. Ganz DA, Wenger NS, Roth CP, Kamberg CJ, Chang JT, MacLean CH, Young RT, Solomon DH, Higashi T, Min L, Reuben DB, Shekelle PG. PMID: 17279017.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    82. Patients' global ratings of their health care are not associated with the technical quality of their care. Ann Intern Med. 2006 May 02; 144(9):665-72. Chang JT, Hays RD, Shekelle PG, MacLean CH, Solomon DH, Reuben DB, Roth CP, Kamberg CJ, Adams J, Young RT, Wenger NS. PMID: 16670136.
      View in: PubMed   Mentions: 92     Fields:    Translation:Humans
    83. Drug insight: antagonists of tumor-necrosis factor-alpha in the treatment of inflammatory bowel disease. Nat Clin Pract Gastroenterol Hepatol. 2006 Apr; 3(4):220-8. Chang JT, Lichtenstein GR. PMID: 16582964.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    84. Gastroesophageal reflux disease, Barrett esophagus, and esophageal adenocarcinoma. Arch Intern Med. 2004 Jul 26; 164(14):1482-8. Chang JT, Katzka DA. PMID: 15277277.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    85. The quality of pharmacologic care for vulnerable older patients. Ann Intern Med. 2004 May 04; 140(9):714-20. Higashi T, Shekelle PG, Solomon DH, Knight EL, Roth C, Chang JT, Kamberg CJ, MacLean CH, Young RT, Adams J, Reuben DB, Avorn J, Wenger NS. PMID: 15126255.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
    86. Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials. BMJ. 2004 Mar 20; 328(7441):680. Chang JT, Morton SC, Rubenstein LZ, Mojica WA, Maglione M, Suttorp MJ, Roth EA, Shekelle PG. PMID: 15031239; PMCID: PMC381224.
      View in: PubMed   Mentions: 240     Fields:    Translation:Humans
    87. Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells. J Immunol. 2000 Jul 15; 165(2):915-24. Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang JT, Wu CY, Seder RA. PMID: 10878366.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    88. CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo. J Immunol. 2000 Jun 01; 164(11):5683-8. Segal BM, Chang JT, Shevach EM. PMID: 10820244.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    89. The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit. Eur J Immunol. 2000 Apr; 30(4):1113-9. Chang JT, Segal BM, Nakanishi K, Okamura H, Shevach EM. PMID: 10760800.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    90. Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity. J Immunol. 2000 Jan 01; 164(1):100-6. Chang JT, Segal BM, Shevach EM. PMID: 10604999.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    91. Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J Exp Med. 1999 Mar 15; 189(6):969-78. Chang JT, Shevach EM, Segal BM. PMID: 10075980; PMCID: PMC2193042.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    92. The critical role of IL-12 and the IL-12R beta 2 subunit in the generation of pathogenic autoreactive Th1 cells. Springer Semin Immunopathol. 1999; 21(3):249-62. Shevach EM, Chang JT, Segal BM. PMID: 10666772.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
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