-
Scaling the cellular frontier: Mechanobiology, tissue dynamics and function. Curr Opin Cell Biol. 2024 Feb; 86:102318.
Trejo J, Scita G. PMID: 38215514.
View in:
PubMed Mentions: Fields:
Translation:
Cells
-
Early career Latinas in STEM: Challenges and solutions. Cell. 2023 Nov 09; 186(23):4985-4991.
Werner Washburne M, Trejo J, Zambrana RE, Zavala ME, Martinic A, Riestra A, Delgado T, Edwards S, Escobar T, Jamison-McClung D, Vazquez M, Vera I, Guerra M, Marinez DI, Gonzalez E, Rodriguez RL. PMID: 37949054.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
Diversity, Equity and Inclusion in the Laboratory: Strategies to Enhance Inclusive Laboratory Culture. Mol Cell. 2023 Nov 02; 83(21):3766-3772.
Marshall AG, Vue Z, Beasley HK, Neikirk K, Stephens D, Wanjalla CN, Damo SM, Trejo J, Rodriguez-Aliaga P, Headley CA, Shuler H, Liu K, Smith N, Garza-Lopez E, Barongan T, Scudese E, Spencer E, Heemstra J, Vazquez AD, Murray SA, Hinton A. PMID: 37922871; PMCID: PMC10986851.
View in:
PubMed Mentions:
1 Fields:
-
An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses. J Biol Chem. 2023 Dec; 299(12):105370.
Cheng N, Trejo J. PMID: 37865315; PMCID: PMC10694601.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
Endothelial APC/PAR1 distinctly regulates cytokine-induced pro-inflammatory VCAM-1 expression. Front Mol Biosci. 2023; 10:1211597.
Birch CA, Wedegaertner H, Orduña-Castillo LB, Gonzalez Ramirez ML, Qin H, Trejo J. PMID: 37692066; PMCID: PMC10483999.
View in:
PubMed Mentions:
-
Divergent regulation of α-arrestin ARRDC3 function by ubiquitination. Mol Biol Cell. 2023 08 01; 34(9):ar93.
Wedegaertner H, Bosompra O, Kufareva I, Trejo J. PMID: 37223976; PMCID: PMC10398895.
View in:
PubMed Mentions: Fields:
Translation:
Cells
-
Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration. J Neurosci. 2023 05 24; 43(21):3970-3984.
Lawrence JA, Aguilar-Calvo P, Ojeda-Juárez D, Khuu H, Soldau K, Pizzo DP, Wang J, Malik A, Shay TF, Sullivan EE, Aulston B, Song SM, Callender JA, Sanchez H, Geschwind MD, Roy S, Rissman RA, Trejo J, Tanaka N, Wu C, Chen X, Patrick GN, Sigurdson CJ. PMID: 37019623; PMCID: PMC10219035.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Building a laboratory and networks during the COVID-19 pandemic. Trends Biochem Sci. 2022 09; 47(9):725-727.
Nicholas DA, Trejo J, Termini CM. PMID: 35606213; PMCID: PMC9121306.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansPHPublic Health
-
Phosphoproteomic analysis of thrombin- and p38 MAPK-regulated signaling networks in endothelial cells. J Biol Chem. 2022 04; 298(4):101801.
Molinar-Inglis O, Wozniak JM, Grimsey NJ, Orduña-Castillo LB, Cheng N, Lin Y, Gonzalez Ramirez ML, Birch CA, Lapek JD, Gonzalez DJ, Trejo J. PMID: 35257745; PMCID: PMC8987612.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
COVID-19 threatens faculty diversity: postdoctoral scholars call for action. Mol Biol Cell. 2022 03 01; 33(3):vo1.
Andrade B, Medina-Munoz HC, Montaño ET, Roa JN, Sánchez RG, Tat J, Hurst S, Mouchka ME, Trejo J, Ramirez MLG. PMID: 35179995; PMCID: PMC9250390.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCellsPHPublic Health
-
The α-Arrestin ARRDC3 Is an Emerging Multifunctional Adaptor Protein in Cancer. Antioxid Redox Signal. 2022 05; 36(13-15):1066-1079.
Wedegaertner H, Pan WA, Gonzalez CC, Gonzalez DJ, Trejo J. PMID: 34465145; PMCID: PMC9127825.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
A system-wide health sciences faculty mentor training program is associated with improved effective mentoring and institutional climate. J Clin Transl Sci. 2022; 6(1):e18.
Trejo J, Wingard D, Hazen V, Bortnick A, Van Hoesen K, Byars-Winston A, Pfund C, Reznik V. PMID: 35291213; PMCID: PMC8889225.
View in:
PubMed Mentions:
6
-
aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis. Proc Natl Acad Sci U S A. 2021 12 07; 118(49).
Molinar-Inglis O, Birch CA, Nicholas D, Orduña-Castillo L, Cisneros-Aguirre M, Patwardhan A, Chen B, Grimsey NJ, Coronel LJ, Lin H, Gomez Menzies PK, Lawson MA, Patel HH, Trejo J. PMID: 34873055; PMCID: PMC8670512.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption. Sci Signal. 2021 Aug 31; 14(698):eabc1044.
Rada CC, Mejia-Pena H, Grimsey NJ, Canto Cordova I, Olson J, Wozniak JM, Gonzalez DJ, Nizet V, Trejo J. PMID: 34516752; PMCID: PMC8538426.
View in:
PubMed Mentions:
13 Fields:
-
α-Arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis. J Cell Sci. 2021 04 15; 134(8).
Arakaki AKS, Pan WA, Wedegaertner H, Roca-Mercado I, Chinn L, Gujral TS, Trejo J. PMID: 33722977; PMCID: PMC8084569.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Post-Translational Modifications of G Protein-Coupled Receptors Control Cellular Signaling Dynamics in Space and Time. Pharmacol Rev. 2021 01; 73(1):120-151.
Patwardhan A, Cheng N, Trejo J. PMID: 33268549; PMCID: PMC7736832.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
-
The burden of service for faculty of color to achieve diversity and inclusion: the minority tax. Mol Biol Cell. 2020 12 01; 31(25):2752-2754.
Trejo J. PMID: 33253072; PMCID: PMC7851863.
View in:
PubMed Mentions:
19 Fields:
Translation:
Humans
-
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus. Nat Commun. 2020 11 30; 11(1):6088.
Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J. PMID: 33257668; PMCID: PMC7705703.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
-
Subcellular hot spots of GPCR signaling promote vascular inflammation. Curr Opin Endocr Metab Res. 2021 Feb; 16:37-42.
Birch CA, Molinar-Inglis O, Trejo J. PMID: 32838054; PMCID: PMC7431397.
View in:
PubMed Mentions:
13
-
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics. Elife. 2020 05 26; 9.
Keyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Zhang J, Ling M, Trejo J, Levchenko A, Zhang J. PMID: 32452765; PMCID: PMC7289600.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
-
Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function. Proc Natl Acad Sci U S A. 2020 03 03; 117(9):5039-5048.
Lin Y, Wozniak JM, Grimsey NJ, Girada S, Patwardhan A, Molinar-Inglis O, Smith TH, Lapek JD, Gonzalez DJ, Trejo J. PMID: 32071217; PMCID: PMC7060683.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
Endo-lysosomal sorting of G protein-coupled receptors by ubiquitin: Diverse pathways for GPCR destruction and beyond
. Traffic. 2019; 20(2):101-109.
M. R. Dores, J. Trejo. .
-
A modular laboratory course using planarians to study genes involved in tissue regeneration. Biochem. and Mol. Biol. Education. 2019; 47(5):547-559.
S.D. Ochoa, M.R. Dores, J.M. Allen, T. Tran, M. Osman, N.P. Vazquez-Castellanos, J. Trejo, R. Zayas.
-
G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells. J Biol Chem. 2019 04 12; 294(15):5867-5878.
Grimsey NJ, Lin Y, Narala R, Rada CC, Mejia-Pena H, Trejo J. PMID: 30760523; PMCID: PMC6463731.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
-
The alpha-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein-coupled receptor lysosomal sorting and signaling. J. Biol. Chem. 2018; 293:3350-3362.
A.K.S. Arakaki, W.A. Pan, H. Lin, J. Trejo. .
-
A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. Cell Rep. 2018 09 18; 24(12):3312-3323.e5.
Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. PMID: 30232011; PMCID: PMC6226018.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansCells
-
GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling. Int J Mol Sci. 2018 Jun 27; 19(7).
Arakaki AKS, Pan WA, Trejo J. PMID: 29954076; PMCID: PMC6073120.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
-
Faculty Equity, Diversity, Culture and Climate Change in Academic Medicine: A Longitudinal Study. J Natl Med Assoc. 2019 Feb; 111(1):46-53.
Wingard D, Trejo J, Gudea M, Goodman S, Reznik V. PMID: 30129483.
View in:
PubMed Mentions:
12 Fields:
Translation:
Humans
-
The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Sci Signal. 2018 02 13; 11(517).
Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. PMID: 29440509; PMCID: PMC5957084.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
-
A reflection on faculty diversity in the 21st century. Mol Biol Cell. 2017 Nov 01; 28(22):2911-2914.
Trejo J. PMID: 29084907; PMCID: PMC5662248.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
-
Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins. J Biol Chem. 2016 08 26; 291(35):18453-64.
Smith TH, Coronel LJ, Li JG, Dores MR, Nieman MT, Trejo J. PMID: 27402844; PMCID: PMC5000090.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
-
ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif. PLoS One. 2016; 11(6):e0157587.
Dores MR, Grimsey NJ, Mendez F, Trejo J. PMID: 27301021; PMCID: PMC4907476.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
-
Integration of endothelial protease-activated receptor-1 inflammatory signaling by ubiquitin. Curr Opin Hematol. 2016 May; 23(3):274-9.
Grimsey NJ, Trejo J. PMID: 26845544; PMCID: PMC4978167.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
-
Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins. J Biol Chem. 2016 Jan 29; 291(5):2223-36.
Grimsey NJ, Coronel LJ, Cordova IC, Trejo J. PMID: 26635365; PMCID: PMC4732206.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
-
The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting. Mol Biol Cell. 2015 Dec 15; 26(25):4660-73.
Dores MR, Lin H, J Grimsey N, Mendez F, Trejo J. PMID: 26490116; PMCID: PMC4678022.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansCells
-
Chapter 20, GPCR Sorting at Multivesicular Endosomes. Methods in Cell Biology – Sorting and Recycling Endosomes. 2015; 130:319-332.
M. R. Dores, J. Trejo. .
-
Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015 Sep 28; 210(7):1117-31.
Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J. PMID: 26391660; PMCID: PMC4586747.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
-
GPCR sorting at multivesicular endosomes. Methods Cell Biol. 2015; 130:319-32.
Dores MR, Trejo J. PMID: 26360043; PMCID: PMC6215325.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):E3600-8.
Soto AG, Smith TH, Chen B, Bhattacharya S, Cordova IC, Kenakin T, Vaidehi N, Trejo J. PMID: 26100877; PMCID: PMC4500229.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
-
Group B streptococcal infection and activation of human astrocytes. PLoS One. 2015; 10(6):e0128431.
Stoner TD, Weston TA, Trejo J, Doran KS. PMID: 26030618; PMCID: PMC4452173.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Dev Biol. 2015 Aug 15; 404(2):49-60.
Yang H, Fang L, Zhan R, Hegarty JM, Ren J, Hsiai TK, Gleeson JG, Miller YI, Trejo J, Chi NC. PMID: 26004360; PMCID: PMC4515213.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
-
Characterization of thrombin-bound dabigatran effects on protease-activated receptor-1 expression and signaling in vitro. Mol Pharmacol. 2015 Jul; 88(1):95-105.
Chen B, Soto AG, Coronel LJ, Goss A, van Ryn J, Trejo J. PMID: 25934730; PMCID: PMC4468637.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Imagining Possibilities (ed. L. Bridges). Open a World of Possible. Real Stories About the Power and Joy of Reading
. 2014; 56-57.
J. Trejo. .
-
A general method for site specific fluorescent labeling of recombinant chemokines. PLoS One. 2014; 9(1):e81454.
Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM. PMID: 24489642; PMCID: PMC3904831.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Endosomal signaling by protease-activated receptors. Methods Enzymol. 2014; 535:389-401.
Grimsey N, Lin H, Trejo J. PMID: 24377935; PMCID: PMC4085098.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
Atypical regulation of G protein-coupled receptor intracellular trafficking by ubiquitination. Curr Opin Cell Biol. 2014 Apr; 27:44-50.
Dores MR, Trejo J. PMID: 24680429; PMCID: PMC4020713.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
-
Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. J Biol Chem. 2014 Jan 17; 289(3):1580-91.
Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J. PMID: 24297163; PMCID: PMC3894338.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
Cofactoring and dimerization of proteinase-activated receptors. Pharmacol Rev. 2013; 65(4):1198-213.
Lin H, Liu AP, Smith TH, Trejo J. PMID: 24064459; PMCID: PMC3799237.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
-
The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization. J Biol Chem. 2013 Nov 08; 288(45):32194-32210.
Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel TM. PMID: 24056371; PMCID: PMC3820859.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
-
Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting. J Biol Chem. 2013 May 31; 288(22):15900-12.
Canto I, Trejo J. PMID: 23580642; PMCID: PMC3668746.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits β-arrestin-mediated endosomal signaling. J Biol Chem. 2013 Apr 19; 288(16):11203-15.
Lin H, Trejo J. PMID: 23476015; PMCID: PMC3630854.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
-
PAR-1 contributes to the innate immune response during viral infection. J Clin Invest. 2013 Mar; 123(3):1310-22.
Antoniak S, Owens AP, Baunacke M, Williams JC, Lee RD, Weithäuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Kirchhofer D, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman N. PMID: 23391721; PMCID: PMC3582138.
View in:
PubMed Mentions:
79 Fields:
Translation:
HumansAnimalsCells
-
Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling. Cell Signal. 2013 Mar; 25(3):707-16.
Marchese A, Trejo J. PMID: 23201781; PMCID: PMC3593103.
View in:
PubMed Mentions:
46 Fields:
Translation:
HumansCells
-
Allosteric modulation of protease-activated receptor signaling. Mini Rev Med Chem. 2012 Aug; 12(9):804-11.
Canto I, Soh UJ, Trejo J. PMID: 22681248; PMCID: PMC4237590.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansCells
-
AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway. Mol Biol Cell. 2012 Sep; 23(18):3612-23.
Dores MR, Paing MM, Lin H, Montagne WA, Marchese A, Trejo J. PMID: 22833563; PMCID: PMC3442409.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansCells
-
Ubiquitination of G protein-coupled receptors: functional implications and drug discovery. Mol Pharmacol. 2012 Oct; 82(4):563-70.
Dores MR, Trejo J. PMID: 22700696; PMCID: PMC3463220.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
-
ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. J Cell Biol. 2012 Apr 30; 197(3):407-19.
Dores MR, Chen B, Lin H, Soh UJ, Paing MM, Montagne WA, Meerloo T, Trejo J. PMID: 22547407; PMCID: PMC3341166.
View in:
PubMed Mentions:
100 Fields:
Translation:
HumansCells
-
Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. J Biol Chem. 2012 Mar 16; 287(12):9013-27.
Malik R, Soh UJ, Trejo J, Marchese A. PMID: 22275353; PMCID: PMC3308791.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansCells
-
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):E1372-80.
Soh UJ, Trejo J. PMID: 22106258; PMCID: PMC3250136.
View in:
PubMed Mentions:
85 Fields:
Translation:
HumansCells
-
Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals. J Biol Chem. 2011 Nov 25; 286(47):40760-70.
Chen B, Dores MR, Grimsey N, Canto I, Barker BL, Trejo J. PMID: 21965661; PMCID: PMC3220480.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
-
Regulation of protease-activated receptor signaling by post-translational modifications. IUBMB Life. 2011 Jun; 63(6):403-11.
Grimsey N, Soto AG, Trejo J. PMID: 21438117; PMCID: PMC3121918.
View in:
PubMed Mentions:
9 Fields:
Translation:
Cells
-
Chapter 5, Dysregulation of G Protein-Coupled Receptor Signaling in Cancer. (eds A. Sitaramayya)
. Signal Transduction: Pathways, Mechanisms and Diseases. 2010; 83-98.
J. Trejo. .
-
RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. Am J Physiol Cell Physiol. 2010 Sep; 299(3):C654-64.
Laroche G, Giguère PM, Roth BL, Trejo J, Siderovski DP. PMID: 20573995; PMCID: PMC2944319.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
Signal transduction by protease-activated receptors. Br J Pharmacol. 2010 May; 160(2):191-203.
Soh UJ, Dores MR, Chen B, Trejo J. PMID: 20423334; PMCID: PMC2874842.
View in:
PubMed Mentions:
134 Fields:
Translation:
HumansAnimalsCells
-
N-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization. J Biol Chem. 2010 Jun 11; 285(24):18781-93.
Soto AG, Trejo J. PMID: 20368337; PMCID: PMC2881801.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
-
Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization. J Biol Chem. 2009 Dec 04; 284(49):34444-57.
Ricks TK, Trejo J. PMID: 19815543; PMCID: PMC2797212.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
-
Chapter 3, Regulation of Thrombin Receptor Signaling (eds. M. E. Maragoudakis and N. E. Tsopanoglou). Thrombin: Physiology and Disease. 2009; 47-61.
J. Trejo. .
-
Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways. J Biol Chem. 2009 Jul 31; 284(31):20638-48.
Seminario-Vidal L, Kreda S, Jones L, O'Neal W, Trejo J, Boucher RC, Lazarowski ER. PMID: 19439413; PMCID: PMC2742828.
View in:
PubMed Mentions:
60 Fields:
Translation:
HumansCells
-
Proteases display biased agonism at protease-activated receptors: location matters! Mol Interv. 2009 Apr; 9(2):87-96.
Russo A, Soh UJ, Trejo J. PMID: 19401541; PMCID: PMC3139377.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
-
Caveolae are required for protease-selective signaling by protease-activated receptor-1. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6393-7.
Russo A, Soh UJ, Paing MM, Arora P, Trejo J. PMID: 19332793; PMCID: PMC2669384.
View in:
PubMed Mentions:
84 Fields:
Translation:
HumansCells
-
Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion. Oncogene. 2008 Jul 24; 27(32):4434-45.
Arora P, Cuevas BD, Russo A, Johnson GL, Trejo J. PMID: 18372913; PMCID: PMC2874884.
View in:
PubMed Mentions:
72 Fields:
Translation:
HumansAnimalsCells
-
Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Nucleic Acids Res. 2008 May; 36(8):2764-76.
Alam MR, Dixit V, Kang H, Li ZB, Chen X, Trejo J, Fisher M, Juliano RL. PMID: 18367474; PMCID: PMC2377441.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansCells
-
G protein-coupled receptor sorting to endosomes and lysosomes. Annu Rev Pharmacol Toxicol. 2008; 48:601-29.
Marchese A, Paing MM, Temple BR, Trejo J. PMID: 17995450; PMCID: PMC2869288.
View in:
PubMed Mentions:
229 Fields:
Translation:
HumansCells
-
Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J Biol Chem. 2007 Dec 21; 282(51):36971-9.
Bhandari D, Trejo J, Benovic JL, Marchese A. PMID: 17947233.
View in:
PubMed Mentions:
108 Fields:
Translation:
HumansCells
-
Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1. J Cell Biol. 2007 Jun 04; 177(5):905-16.
Wolfe BL, Marchese A, Trejo J. PMID: 17535965; PMCID: PMC2064289.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
-
Protease-activated receptor signaling: new roles and regulatory mechanisms. Curr Opin Hematol. 2007 May; 14(3):230-5.
Traynelis SF, Trejo J. PMID: 17414212.
View in:
PubMed Mentions:
51 Fields:
Translation:
HumansCells
-
Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis. Traffic. 2007 May; 8(5):462-70.
Wolfe BL, Trejo J. PMID: 17376169.
View in:
PubMed Mentions:
112 Fields:
-
Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer. J Cell Sci. 2007 Mar 15; 120(Pt 6):921-8.
Arora P, Ricks TK, Trejo J. PMID: 17344429.
View in:
PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
-
Cryptic messages: is noncoagulant tissue factor reserved for cell signaling? Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14259-60.
Camerer E, Trejo J. PMID: 16985001; PMCID: PMC1599949.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. Mol Biol Cell. 2006 Sep; 17(9):4142-55.
Dho SE, Trejo J, Siderovski DP, McGlade CJ. PMID: 16837553; PMCID: PMC1593178.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
-
Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Mol Cell Biol. 2006 Apr; 26(8):3231-42.
Paing MM, Johnston CA, Siderovski DP, Trejo J. PMID: 16581796; PMCID: PMC1446942.
View in:
PubMed Mentions:
61 Fields:
Translation:
HumansCells
-
An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol Biol Cell. 2006 Mar; 17(3):1228-38.
Gullapalli A, Wolfe BL, Griffin CT, Magnuson T, Trejo J. PMID: 16407403; PMCID: PMC1382312.
View in:
PubMed Mentions:
69 Fields:
Translation:
HumansCells
-
Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells. Cancer Res. 2006 Jan 01; 66(1):307-14.
Morris DR, Ding Y, Ricks TK, Gullapalli A, Wolfe BL, Trejo J. PMID: 16397244.
View in:
PubMed Mentions:
90 Fields:
Translation:
HumansAnimalsCells
-
A requirement for membrane cholesterol in the beta-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors. J Cell Sci. 2005 Nov 15; 118(Pt 22):5291-304.
Urs NM, Jones KT, Salo PD, Severin JE, Trejo J, Radhakrishna H. PMID: 16263766.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
-
Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15173-7.
Griffin CT, Trejo J, Magnuson T. PMID: 16214895; PMCID: PMC1257690.
View in:
PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
-
Internal PDZ ligands: novel endocytic recycling motifs for G protein-coupled receptors. Mol Pharmacol. 2005 May; 67(5):1388-90.
Trejo J. PMID: 15713849.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
-
Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking. Mol Pharmacol. 2005 Jan; 67(1):78-87.
Stalheim L, Ding Y, Gullapalli A, Paing MM, Wolfe BL, Morris DR, Trejo J. PMID: 15475570.
View in:
PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
-
A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1: multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization. J Biol Chem. 2004 May 21; 279(21):21938-47.
Paing MM, Temple BR, Trejo J. PMID: 15023990.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
-
Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol Cell Biol. 2004 Mar; 24(5):1990-9.
Booden MA, Eckert LB, Der CJ, Trejo J. PMID: 14966279; PMCID: PMC350540.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansCells
-
A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Mol Biol Cell. 2004 May; 15(5):2143-55.
Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J. PMID: 14978220; PMCID: PMC404011.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansCells
-
Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation. J Biol Chem. 2004 Mar 12; 279(11):10020-31.
Chen CH, Paing MM, Trejo J. PMID: 14699102.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
-
Protease-activated receptors: new concepts in regulation of G protein-coupled receptor signaling and trafficking. J Pharmacol Exp Ther. 2003 Nov; 307(2):437-42.
Trejo J. PMID: 12966163.
View in:
PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
-
Beta-arrestins regulate protease-activated receptor-1 desensitization but not internalization or down-regulation. J. Biol. Chem. 2002; 277:1292-1300.
M.M. Paing, A. B. Stutts, T.A. Kohout, R. J. Lefkowitz, J. Trejo. .
-
Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1.
. Mol. Biol. Cell. 2002; 13:1965-1976.
Y. Wang, Y. Zhou, K. Szabo, C.R. Haft, J. Trejo. .
-
Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. J Biol Chem. 2000 Oct 06; 275(40):31255-65.
Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR. PMID: 10893235.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansCells
-
Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. Blood. 1999 Dec 15; 94(12):4112-21.
Kahn ML, Diacovo TG, Bainton DF, Lanza F, Trejo J, Coughlin SR. PMID: 10590056.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
-
The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. J Biol Chem. 1999 Jan 22; 274(4):2216-24.
Trejo J, Coughlin SR. PMID: 9890984.
View in:
PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
-
Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13698-702.
Trejo J, Hammes SR, Coughlin SR. PMID: 9811863; PMCID: PMC24882.
View in:
PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
-
Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. J Biol Chem. 1996 Dec 20; 271(51):32874-80.
Shapiro MJ, Trejo J, Zeng D, Coughlin SR. PMID: 8955127.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem. 1996 Aug 30; 271(35):21536-41.
Trejo J, Connolly AJ, Coughlin SR. PMID: 8702939.
View in:
PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
-
Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr Biol. 1996 May 01; 6(5):598-605.
Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J. PMID: 8805275.
View in:
PubMed Mentions:
78 Fields:
Translation:
HumansAnimalsCells
-
A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. J Biol Chem. 1994 Aug 26; 269(34):21682-90.
Trejo J, Massamiri T, Deng T, Dewji NN, Bayney RM, Brown JH. PMID: 8063812.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
-
Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation. Mol Cell Biol. 1992 Oct; 12(10):4742-50.
Trejo J, Chambard JC, Karin M, Brown JH. PMID: 1328861; PMCID: PMC360401.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
-
c-fos and c-jun are induced by muscarinic receptor activation of protein kinase C but are differentially regulated by intracellular calcium. J Biol Chem. 1991 Apr 25; 266(12):7876-82.
Trejo J, Brown JH. PMID: 1902229.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
-
Multiple pathways for signal transduction through the muscarinic cholinergic receptor. Prog Brain Res. 1990; 84:21-9.
Brown JH, Trilivas I, Trejo J, Martinson E. PMID: 2267298.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells