Geoffrey Wahl

Title(s)Adjunct Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Understanding how metabolic heterogeneity in cancer affects the tumor microenvironment and anti-tumor immunity
    NIH R01CA240909Mar 1, 2020 - Feb 28, 2025
    Role: Co-Principal Investigator
    Combining single cell approaches and a developmental perspective to discover stem cell control circuits and the cellular and molecular bases of cancer heterogeneity
    NIH R35CA197687Aug 1, 2015 - Jul 31, 2022
    Role: Principal Investigator
    High throughput screen for inhibitors of the mdm2/mdmx interaction
    NIH R03MH089489Feb 1, 2010 - Nov 30, 2011
    Role: Principal Investigator
    Mouse Models to Elucidate p53 Regulatory Mechanisms
    NIH R01CA100845Apr 15, 2003 - Mar 31, 2009
    Role: Principal Investigator
    DECONVOLUTION MICROSCOPE FOR LIVE CELL IMAGING
    NIH S10RR013692Feb 16, 1999 - Feb 15, 2000
    Role: Principal Investigator
    DNA REPLICATION, CELL CYCLE CONTROL AND GENOME FLUIDITY
    NIH R01GM051104Aug 1, 1993 - Jul 31, 1998
    Role: Principal Investigator
    Mechanisms of Genetic Instability and Tumor Suppression
    NIH R01CA061449Jul 1, 1993 - Jul 31, 2011
    Role: Principal Investigator
    MOLECULAR GENETIC ANALYSIS OF MAMMALIAN DNA REPLICATION
    NIH R01CA048405Aug 1, 1988 - Mar 31, 2005
    Role: Principal Investigator
    DETECTION AND CURING OF AMPLIFIED GENES IN CANCER
    NIH U01CA048405Aug 1, 1988 - Jul 31, 1995
    Role: Principal Investigator
    FASEB RESEARCH CONF--CELLULAR AND MOLECULAR GENETICS
    NIH R13CA049116Jul 1, 1988 - Jun 30, 1989
    Role: Principal Investigator
    Salk Institute Cancer Training Grant
    NIH T32CA009370Sep 1, 1980 - Jun 30, 2022
    Role: Co-Principal Investigator
    DRUG RESISTANCE AND GENE AMPLIFICATION IN EUKARYOTES
    NIH R01GM027754Apr 1, 1980 - Jun 30, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cancer as a Disease of Development Gone Awry. Annu Rev Pathol. 2024 Jan 24; 19:397-421. Stanger BZ, Wahl GM. PMID: 37832945.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth. Nat Cell Biol. 2023 Jan; 25(1):159-169. Tang R, Shuldiner EG, Kelly M, Murray CW, Hebert JD, Andrejka L, Tsai MK, Hughes NW, Parker MI, Cai H, Li YC, Wahl GM, Dunbrack RL, Jackson PK, Petrov DA, Winslow MM. PMID: 36635501; PMCID: PMC10521195.
      View in: PubMed   Mentions: 5     Fields:    
    3. Structural variants drive context-dependent oncogene activation in cancer. Nature. 2022 12; 612(7940):564-572. Xu Z, Lee DS, Chandran S, Le VT, Bump R, Yasis J, Dallarda S, Marcotte S, Clock B, Haghani N, Cho CY, Akdemir KC, Tyndale S, Futreal PA, McVicker G, Wahl GM, Dixon JR. PMID: 36477537; PMCID: PMC9810360.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    4. Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer. Cancer Discov. 2022 12 02; 12(12):2930-2953. Langille E, Al-Zahrani KN, Ma Z, Liang M, Uuskula-Reimand L, Espin R, Teng K, Malik A, Bergholtz H, Ghamrasni SE, Afiuni-Zadeh S, Tsai R, Alvi S, Elia A, Lü Y, Oh RH, Kozma KJ, Trcka D, Narimatsu M, Liu JC, Nguyen T, Barutcu S, Loganathan SK, Bremner R, Bader GD, Egan SE, Cescon DW, Sørlie T, Wrana JL, Jackson HW, Wilson MD, Witkiewicz AK, Knudsen ES, Pujana MA, Wahl GM, Schramek D. PMID: 36108220; PMCID: PMC9812400.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    5. Eicosanoids in the pancreatic tumor microenvironment - a multicellular, multifaceted progression. Gastro Hep Adv. 2022; 1(4):682-697. Gubbala VB, Jytosana N, Trinh VQ, Maurer HC, Naeem RF, Lytle NK, Ma Z, Zhao S, Lin W, Han H, Shi Y, Hunter T, Singh PK, Olive KP, Tan MCB, Kaech SM, Wahl GM, DelGiorno KE. PMID: 36277993; PMCID: PMC9583893.
      View in: PubMed   Mentions: 1  
    6. Single-Cell Transcriptomic and Epigenetic Analyses of Mouse Mammary Development Starting with the Embryo. Methods Mol Biol. 2022; 2471:49-82. Ma Z, Lytle NK, Ramos C, Naeem RF, Wahl GM. PMID: 35175591; PMCID: PMC9663269.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2021 Dec; 600(7889):E18. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 34848876.
      View in: PubMed   Mentions: 1     Fields:    
    8. Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury. Gastroenterology. 2022 02; 162(2):604-620.e20. Ma Z, Lytle NK, Chen B, Jyotsana N, Novak SW, Cho CJ, Caplan L, Ben-Levy O, Neininger AC, Burnette DT, Trinh VQ, Tan MCB, Patterson EA, Arrojo E Drigo R, Giraddi RR, Ramos C, Means AL, Matsumoto I, Manor U, Mills JC, Goldenring JR, Lau KS, Wahl GM, DelGiorno KE. PMID: 34695382; PMCID: PMC8792222.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    9. Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2. Gastroenterology. 2020 11; 159(5):1866-1881.e8. DelGiorno KE, Chung CY, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O'Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, Wahl GM. PMID: 32717220; PMCID: PMC7680354.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    10. Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer. Cell Rep. 2020 06 09; 31(10):107742. Christin JR, Wang C, Chung CY, Liu Y, Dravis C, Tang W, Oktay MH, Wahl GM, Guo W. PMID: 32521267; PMCID: PMC7658810.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    11. Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders. Proc Natl Acad Sci U S A. 2020 06 02; 117(22):12121-12130. Li YC, Lytle NK, Gammon ST, Wang L, Hayes TK, Sutton MN, Bast RC, Der CJ, Piwnica-Worms D, McCormick F, Wahl GM. PMID: 32424096; PMCID: PMC7275768.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    12. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science. 2020 04 03; 368(6486):85-89. Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP. PMID: 32241947; PMCID: PMC7681911.
      View in: PubMed   Mentions: 380     Fields:    Translation:HumansAnimalsCells
    13. Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis. Front Physiol. 2020; 11:88. DelGiorno KE, Naeem RF, Fang L, Chung CY, Ramos C, Luhtala N, O'Connor C, Hunter T, Manor U, Wahl GM. PMID: 32116793; PMCID: PMC7033634.
      View in: PubMed   Mentions: 18  
    14. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Sci Alliance. 2020 01; 3(1). Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer MW. PMID: 31959624; PMCID: PMC6971368.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    15. DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters. Cell Rep. 2019 12 10; 29(11):3448-3459.e6. Sutton MN, Lu Z, Li YC, Zhou Y, Huang T, Reger AS, Hurwitz AM, Palzkill T, Logsdon C, Liang X, Gray JW, Nan X, Hancock J, Wahl GM, Bast RC. PMID: 31825828; PMCID: PMC6948147.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    16. Single-Cell Chromatin Analysis of Mammary Gland Development Reveals Cell-State Transcriptional Regulators and Lineage Relationships. Cell Rep. 2019 10 08; 29(2):495-510.e6. Chung CY, Ma Z, Dravis C, Preissl S, Poirion O, Luna G, Hou X, Giraddi RR, Ren B, Wahl GM. PMID: 31597106; PMCID: PMC6887110.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    17. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019 05; 569(7754):131-135. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 30996350; PMCID: PMC6565370.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    18. Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. Cancer Cell. 2018 09 10; 34(3):466-482.e6. Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. PMID: 30174241; PMCID: PMC6152943.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    19. Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development. Cell Rep. 2018 08 07; 24(6):1653-1666.e7. Giraddi RR, Chung CY, Heinz RE, Balcioglu O, Novotny M, Trejo CL, Dravis C, Hagos BM, Mehrabad EM, Rodewald LW, Hwang JY, Fan C, Lasken R, Varley KE, Perou CM, Wahl GM, Spike BT. PMID: 30089273; PMCID: PMC6301014.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    20. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PLoS One. 2017; 12(12):e0189051. Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM. PMID: 29211796; PMCID: PMC5718507.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    21. Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis. NPJ Breast Cancer. 2017; 3:16. Trejo CL, Luna G, Dravis C, Spike BT, Wahl GM. PMID: 28649656; PMCID: PMC5460261.
      View in: PubMed   Mentions: 17  
    22. Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity. NPJ Breast Cancer. 2017; 3:14. Wahl GM, Spike BT. PMID: 28649654; PMCID: PMC5460241.
      View in: PubMed   Mentions: 74  
    23. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237; PMCID: PMC5334176.
      View in: PubMed   Mentions: 308     Fields:    Translation:HumansCells
    24. [Pilot study of laser-doppler flowmetry measurement of oral mucosa blood flow]. Beijing Da Xue Xue Bao Yi Xue Ban. 2016 Aug 18; 48(4):697-701. Wang Y, Barry O, Wahl G, Chen B, Lin Y. PMID: 29263516.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016 Feb 22; 7:10743. Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl GM, Verma IM, Laurent LC, Izpisua Belmonte JC. PMID: 26899176; PMCID: PMC4764898.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    26. [Pilot study of laser-doppler flowmetry measurement of oral mucosa blood flow]. Beijing Da Xue Xue Bao Yi Xue Ban. 2016 Feb 18; 48(1):697-701. Wang Y, Barry O, Wahl G, Chen B, Lin Y. PMID: 27538155.
      View in: PubMed   Mentions:    Fields:    
    27. Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells. Cell Rep. 2015 Sep 29; 12(12):2035-48. Dravis C, Spike BT, Harrell JC, Johns C, Trejo CL, Southard-Smith EM, Perou CM, Wahl GM. PMID: 26365194; PMCID: PMC4591253.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    28. The Trp53 delta proline (Trp53ΔP) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. Mol Carcinog. 2016 09; 55(9):1387-96. Adams CJ, Yu JS, Mao JH, Jen KY, Costes SV, Wade M, Shoemake J, Aina OH, Del Rosario R, Menchavez PT, Cardiff RD, Wahl GM, Balmain A. PMID: 26310697; PMCID: PMC4891300.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    29. A Critical Examination of the "Bad Luck" Explanation of Cancer Risk. Cancer Prev Res (Phila). 2015 Sep; 8(9):762-4. Rozhok AI, Wahl GM, DeGregori J. PMID: 26122457; PMCID: PMC4849411.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    30. Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy. Breast Cancer Res Treat. 2015 Jan; 149(2):425-37. Pfefferle AD, Spike BT, Wahl GM, Perou CM. PMID: 25575446; PMCID: PMC4308649.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    31. A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. Cell Rep. 2014 Dec 11; 9(5):1946-1958. Li YC, Rodewald LW, Hoppmann C, Wong ET, Lebreton S, Safar P, Patek M, Wang L, Wertman KF, Wahl GM. PMID: 25464845; PMCID: PMC4269221.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    32. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014 Sep 25; 159(1):80-93. Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. PMID: 25259922; PMCID: PMC4177038.
      View in: PubMed   Mentions: 494     Fields:    Translation:HumansAnimalsCells
    33. CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo. Stem Cell Reports. 2014 Apr 08; 2(4):427-39. Spike BT, Kelber JA, Booker E, Kalathur M, Rodewald R, Lipianskaya J, La J, He M, Wright T, Klemke R, Wahl GM, Gray PC. PMID: 24749068; PMCID: PMC3986630.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    34. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 2013 Nov 12; 14(11):R125. Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, Torres-Arzayus MI, Brown M, Egan SE, Wahl GM, Rosen JM, Perou CM. PMID: 24220145; PMCID: PMC4053990.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    35. AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol. 2014 Jan; 34(2):148-57. He G, Zhang YW, Lee JH, Zeng SX, Wang YV, Luo Z, Dong XC, Viollet B, Wahl GM, Lu H. PMID: 24190973; PMCID: PMC3911293.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    36. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem. 2013 Sep 06; 288(36):26301-26310. Rasmussen NR, Wright TM, Brooks SA, Hacker KE, Debebe Z, Sendor AB, Walker MP, Major MB, Green J, Wahl GM, Rathmell WK. PMID: 23893409; PMCID: PMC3764835.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    37. Stem cells and the developing mammary gland. J Mammary Gland Biol Neoplasia. 2013 Jun; 18(2):209-19. Makarem M, Spike BT, Dravis C, Kannan N, Wahl GM, Eaves CJ. PMID: 23624881; PMCID: PMC4161372.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    38. Paracrine Wnt signaling both promotes and inhibits human breast tumor growth. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6991-6. Green JL, La J, Yum KW, Desai P, Rodewald LW, Zhang X, Leblanc M, Nusse R, Lewis MT, Wahl GM. PMID: 23559372; PMCID: PMC3637696.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    39. Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. PLoS One. 2013; 8(3):e58395. Green JL, Bauer M, Yum KW, Li YC, Cox ML, Willert K, Wahl GM. PMID: 23516471; PMCID: PMC3596392.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    40. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer. 2013 Feb; 13(2):83-96. Wade M, Li YC, Wahl GM. PMID: 23303139; PMCID: PMC4161369.
      View in: PubMed   Mentions: 560     Fields:    Translation:HumansAnimals
    41. What a difference a phosphate makes: life or death decided by a single amino acid in MDM2. Cancer Cell. 2012 May 15; 21(5):595-596. Li YC, Wahl GM. PMID: 22624708.
      View in: PubMed   Mentions: 1     Fields:    
    42. Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein. J Biol Chem. 2012 Jun 15; 287(25):20898-903. Lee JH, Jin Y, He G, Zeng SX, Wang YV, Wahl GM, Lu H. PMID: 22556425; PMCID: PMC3375513.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    43. A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell. 2012 Feb 03; 10(2):183-97. Spike BT, Engle DD, Lin JC, Cheung SK, La J, Wahl GM. PMID: 22305568; PMCID: PMC3277444.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    44. Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene. 2012 Nov 08; 31(45):4789-97. Wade M, Li YC, Matani AS, Braun SM, Milanesi F, Rodewald LW, Wahl GM. PMID: 22266850; PMCID: PMC3337965.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    45. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 01; 25(13):1426-38. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. PMID: 21724834; PMCID: PMC3134085.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    46. p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. Genes Cancer. 2011 Apr; 2(4):404-19. Spike BT, Wahl GM. PMID: 21779509; PMCID: PMC3135646.
      View in: PubMed   Mentions: 83  
    47. Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22745-50. Mizuno H, Spike BT, Wahl GM, Levine AJ. PMID: 21149740; PMCID: PMC3012457.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    48. A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell. 2010 Nov 16; 18(5):411-22. Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD. PMID: 21075307; PMCID: PMC3050021.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    49. The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol. 2010 May; 20(5):299-309. Wade M, Wang YV, Wahl GM. PMID: 20172729; PMCID: PMC2910097.
      View in: PubMed   Mentions: 245     Fields:    Translation:HumansAnimalsCells
    50. Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo. Cell Cycle. 2009 Nov 01; 8(21):3443-4. Wang YV, Wade M, Wahl GM. PMID: 19838055; PMCID: PMC2777705.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    51. The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation. J Pathol. 2009 Oct; 219(2):263-74. Ponnamperuma RM, King KE, Elsir T, Glick AB, Wahl GM, Nister M, Weinberg WC. PMID: 19718706; PMCID: PMC4208754.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    52. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature. 2009 Aug 27; 460(7259):1140-4. Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A, Wahl GM, Izpisúa Belmonte JC. PMID: 19668186; PMCID: PMC2735889.
      View in: PubMed   Mentions: 584     Fields:    Translation:HumansAnimalsCells
    53. Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. Cancer Cell. 2009 Jul 07; 16(1):33-43. Wang YV, Leblanc M, Wade M, Jochemsen AG, Wahl GM. PMID: 19573810; PMCID: PMC2758524.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    54. Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? Mol Cancer Res. 2009 Jan; 7(1):1-11. Wade M, Wahl GM. PMID: 19147532; PMCID: PMC2629357.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    55. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. Cell Cycle. 2008 Jul 01; 7(13):1973-82. Wade M, Rodewald LW, Espinosa JM, Wahl GM. PMID: 18604177; PMCID: PMC2625302.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
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    70. The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10188-93. Krummel KA, Lee CJ, Toledo F, Wahl GM. PMID: 16006521; PMCID: PMC1177381.
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    88. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec; 93(3):198-208. Fox RI, Herrmann ML, Frangou CG, Wahl GM, Morris RE, Strand V, Kirschbaum BJ. PMID: 10600330.
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    93. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol Cell. 1998 Dec; 2(6):877-85. Jiang W, Jimenez G, Wells NJ, Hope TJ, Wahl GM, Hunter T, Fukunaga R. PMID: 9885575.
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    137. Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science. 1991 Mar 15; 251(4999):1351-5. O'Gorman S, Fox DT, Wahl GM. PMID: 1900642.
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    138. A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. Genes Dev. 1991 Feb; 5(2):160-74. Windle B, Draper BW, Yin YX, O'Gorman S, Wahl GM. PMID: 1995414.
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    139. Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines. Anticancer Drugs. 1991 Feb; 2(1):11-25. Benner SE, Wahl GM, Von Hoff DD. PMID: 1720337.
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    140. Chromosomal destabilization during gene amplification. Mol Cell Biol. 1990 Jun; 10(6):3056-66. Ruiz JC, Wahl GM. PMID: 2188107; PMCID: PMC360670.
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    141. Blunt-end and single-strand ligations by Escherichia coli ligase: influence on an in vitro amplification scheme. Gene. 1990 Apr 30; 89(1):117-22. Barringer KJ, Orgel L, Wahl G, Gingeras TR. PMID: 2197176.
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    142. Recent progress in understanding mechanisms of mammalian DNA amplification. Cell. 1989 Jun 16; 57(6):901-8. Stark GR, Debatisse M, Giulotto E, Wahl GM. PMID: 2661014.
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    143. The importance of circular DNA in mammalian gene amplification. Cancer Res. 1989 Mar 15; 49(6):1333-40. Wahl GM. PMID: 2647287.
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    144. Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line. Mol Cell Biol. 1989 Jan; 9(1):109-15. Ruiz JC, Choi KH, von Hoff DD, Roninson IB, Wahl GM. PMID: 2648129; PMCID: PMC362151.
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    145. Formation of an inverted duplication can be an initial step in gene amplification. Mol Cell Biol. 1988 Oct; 8(10):4302-13. Ruiz JC, Wahl GM. PMID: 3185551; PMCID: PMC365503.
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    146. Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4804-8. Von Hoff DD, Needham-VanDevanter DR, Yucel J, Windle BE, Wahl GM. PMID: 3164477; PMCID: PMC280524.
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    147. Double minute chromosomes can be produced from precursors derived from a chromosomal deletion. Mol Cell Biol. 1988 Apr; 8(4):1525-33. Carroll SM, DeRose ML, Gaudray P, Moore CM, Needham-Vandevanter DR, Von Hoff DD, Wahl GM. PMID: 2898098; PMCID: PMC363312.
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    148. Mapping and sequencing of the dihydrofolate reductase gene (DFR1) of Saccharomyces cerevisiae. Gene. 1988 Mar 31; 63(2):175-85. Barclay BJ, Huang T, Nagel MG, Misener VL, Game JC, Wahl GM. PMID: 2838386.
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    149. Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin. Mol Cell Biol. 1987 May; 7(5):1740-50. Carroll SM, Gaudray P, De Rose ML, Emery JF, Meinkoth JL, Nakkim E, Subler M, Von Hoff DD, Wahl GM. PMID: 2885742; PMCID: PMC365275.
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    150. Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification. Mol Cell Biol. 1987 Apr; 7(4):1415-24. Meinkoth J, Killary AM, Fournier RE, Wahl GM. PMID: 3600632; PMCID: PMC365229.
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    151. Escherichia coli aspartate transcarbamylase: a novel marker for studies of gene amplification and expression in mammalian cells. Mol Cell Biol. 1986 Sep; 6(9):3050-8. Ruiz JC, Wahl GM. PMID: 3537729; PMCID: PMC367039.
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    152. New RNA species is produced by alternate polyadenylation following rearrangement associated with CAD gene amplification. Somat Cell Mol Genet. 1986 Jul; 12(4):339-50. Meinkoth JL, Legouy E, Brison O, Wahl GM. PMID: 2426798.
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    153. Fluorescent methotrexate labeling and flow cytometric analysis of cells containing low levels of dihydrofolate reductase. J Biol Chem. 1986 May 15; 261(14):6285-92. Gaudray P, Trotter J, Wahl GM. PMID: 3700393.
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    154. Effect of chromosomal position on amplification of transfected genes in animal cells. Nature. 1984 Feb 9-15; 307(5951):516-20. Wahl GM, Robert de Saint Vincent B, DeRose ML. PMID: 6694743.
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    155. Gene amplification. Annu Rev Biochem. 1984; 53:447-91. Stark GR, Wahl GM. PMID: 6383198.
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    156. Co-amplification of rRNA genes with CAD genes in N-(phosphonacetyl)-L-aspartate-resistant Syrian hamster cells. Mol Cell Biol. 1983 Nov; 3(11):2066-75. Wahl GM, Vitto L, Rubnitz J. PMID: 6318080; PMCID: PMC370073.
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    157. Derivatization of unprotected polynucleotides. Nucleic Acids Res. 1983 Sep 24; 11(18):6513-29. Chu BC, Wahl GM, Orgel LE. PMID: 6622259; PMCID: PMC326391.
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    158. Homologous recombination in mammalian cells mediates formation of a functional gene from two overlapping gene fragments. Proc Natl Acad Sci U S A. 1983 Apr; 80(7):2002-6. de Saint Vincent BR, Wahl GM. PMID: 6132383; PMCID: PMC393740.
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    159. Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol. 1982 Nov; 2(11):1372-87. Folger KR, Wong EA, Wahl G, Capecchi MR. PMID: 6298598; PMCID: PMC369942.
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    160. Patents and literature. Appl Biochem Biotechnol. 1982 May; 7(3):217-30. Kit M, Narasimhan MJ, Anderson JA, Zimmermann U, Pilwat G, Furuya T, Tani Y, Kolehmainen SE, Tarkkanen V, Barrett SP, Gestrelius SM, Belloc A, Florent J, Lunel J, Palla J, Mancy D, Bailey JE, Cho YK, Mouri T, Kayama H, Foley SE, Oriel PJ, Epstein CC, Kimura K, Spraker PW, Ljungdahl LG, Wieget JK, Levine DW, Thilly WG, Wang DI, Wong JS, Eisinger MG, Young FE, Wilson GA, Mottice SL, Green H, Kehinde O, Buhler M, Olofsson M, Osseux PF, Degen L, Branduzzi P, Olivieri R, Cimini N, Kang KS, Veeder GT, Latymer Z, Andersen G, Drobot W, Monsheimer R, Pfleiderer E, Hidaka H, Kohno T, Eida T, Weisrock WP, Stevens VC, Takezawa K, Hiratani H, Wandrey C, Wichmann R, Leuchtenberger W, Kula M, Buckmann A, Troller J, Koshugi J, Frommer W, Muller L, Schmidt D, Puls W, Krause H, Heber U, Cohen SN, Wahl GM, Stark GR, Collins J, Hohn B, Sugano H, Matsui Y. PMID: 24234232.
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    161. Properties of dispersed, highly repeated DNA within and near the hamster CAD gene. Mol Cell Biol. 1982 Mar; 2(3):302-7. Padgett RA, Wahl GM, Stark GR. PMID: 6180303; PMCID: PMC369789.
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    162. Structure of the gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells. Mol Cell Biol. 1982 Mar; 2(3):293-301. Padgett RA, Wahl GM, Stark GR. PMID: 6125880; PMCID: PMC369788.
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    163. Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization. Mol Cell Biol. 1982 Mar; 2(3):308-19. Wahl GM, Vitto L, Padgett RA, Stark GR. PMID: 6180304; PMCID: PMC369790.
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    164. The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker. Cell. 1981 Dec; 27(2 Pt 1):267-77. de Saint Vincent BR, Delbrück S, Eckhart W, Meinkoth J, Vitto L, Wahl G. PMID: 6277500.
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    165. Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells. J Biol Chem. 1979 Sep 10; 254(17):8679-89. Wahl GM, Padgett RA, Stark GR. PMID: 381311.
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    166. N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis. J Biol Chem. 1979 Feb 10; 254(3):974-80. Padgett RA, Wahl GM, Coleman PF, Stark GR. PMID: 762107.
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    167. Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper. Methods Enzymol. 1979; 68:220-42. Alwine JC, Kemp DJ, Parker BA, Reiser J, Renart J, Stark GR, Wahl GM. PMID: 94421.
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    168. Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro. Cell. 1975 Nov; 6(3):269-77. Capecchi MR, Hughes SH, Wahl GM. PMID: 802681.
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    169. Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: evidence for mutations at different loci in the HGPRT gene. J Cell Physiol. 1975 Apr; 85(2 Pt 1):307-20. Wahl GM, Hughes SH, Capecchi MR. PMID: 47331.
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    170. Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase. J Biol Chem. 1975 Jan 10; 250(1):120-6. Hughes SH, Wahl GM, Capecchi MR. PMID: 237883.
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