Enfu Hui

Title(s)Associate Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Awards and Honors
    National Cancer Institute2019R37 MERIT Award for ESI
    The Pew Charitable Trust2018Pew Biomedical Scholar
    Searle Scholar Program2018Searle Scholar
    Leukemia & Lymphoma Society2011Postdoctoral Fellowship

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of PD-L1/PD-1 immune checkpoints by cis-interactions
    NIH R37CA239072Mar 1, 2019 - Feb 29, 2024
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity. Nat Immunol. 2023 Dec; 24(12):2032-2041. Tang Z, Zhong MC, Qian J, Galindo CC, Davidson D, Li J, Zhao Y, Hui E, Veillette A. PMID: 37945822.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Cis Interactions of Membrane Receptors and Ligands. Annu Rev Cell Dev Biol. 2023 10 16; 39:391-408. Hui E. PMID: 37339682.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity. Immunity. 2023 06 13; 56(6):1187-1203.e12. Zhao Y, Caron C, Chan YY, Lee CK, Xu X, Zhang J, Masubuchi T, Wu C, Bui JD, Hui E. PMID: 37160118; PMCID: PMC10330546.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    4. CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis. J Exp Med. 2023 07 03; 220(7). Xu X, Dennett P, Zhang J, Sherrard A, Zhao Y, Masubuchi T, Bui JD, Chen X, Hui E. PMID: 37042938; PMCID: PMC10103642.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. In Situ Assembly of Transmembrane Proteins from Expressed and Synthetic Components in Giant Unilamellar Vesicles. ACS Chem Biol. 2022 05 20; 17(5):1015-1021. Podolsky KA, Masubuchi T, Debelouchina GT, Hui E, Devaraj NK. PMID: 35482050; PMCID: PMC9255206.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses. Immunity. 2022 03 08; 55(3):512-526.e9. Banta KL, Xu X, Chitre AS, Au-Yeung A, Takahashi C, O'Gorman WE, Wu TD, Mittman S, Cubas R, Comps-Agrar L, Fulzele A, Bennett EJ, Grogan JL, Hui E, Chiang EY, Mellman I. PMID: 35263569; PMCID: PMC9287124.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    7. Enhancing the therapeutic efficacy of programmed death ligand 1 antibody for metastasized liver cancer by overcoming hepatic immunotolerance in mice. Hepatology. 2022 09; 76(3):630-645. Xin B, Yang M, Wu P, Du L, Deng X, Hui E, Feng GS. PMID: 34860431; PMCID: PMC9163212.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors. Elife. 2021 11 04; 10. Xu X, Masubuchi T, Cai Q, Zhao Y, Hui E. PMID: 34734802; PMCID: PMC8631942.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    9. Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy. Cell. 2020 08 20; 182(4):855-871.e23. Wu W, Zhou Q, Masubuchi T, Shi X, Li H, Xu X, Huang M, Meng L, He X, Zhu H, Gao S, Zhang N, Jing R, Sun J, Wang H, Hui E, Wong CC, Xu C. PMID: 32730808.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    10. PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2. J Cell Biol. 2020 06 01; 219(6). Xu X, Hou B, Fulzele A, Masubuchi T, Zhao Y, Wu Z, Hu Y, Jiang Y, Ma Y, Wang H, Bennett EJ, Fu G, Hui E. PMID: 32437509; PMCID: PMC7265324.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    11. PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways. Immunity. 2019 12 17; 51(6):1059-1073.e9. Zhao Y, Lee CK, Lin CH, Gassen RB, Xu X, Huang Z, Xiao C, Bonorino C, Lu LF, Bui JD, Hui E. PMID: 31757674; PMCID: PMC6935268.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    12. TCR-pMHC bond conformation controls TCR ligand discrimination. Cell Mol Immunol. 2020 03; 17(3):203-217. Sasmal DK, Feng W, Roy S, Leung P, He Y, Cai C, Cao G, Lian H, Qin J, Hui E, Schreiber H, Adams EJ, Huang J. PMID: 31530899; PMCID: PMC7052167.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    13. Understanding T cell signaling using membrane reconstitution. Immunol Rev. 2019 09; 291(1):44-56. Hui E. PMID: 31402497.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    14. Immune checkpoint inhibitors. J Cell Biol. 2019 03 04; 218(3):740-741. Hui E. PMID: 30760493; PMCID: PMC6400575.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    15. Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells. Cell Rep. 2018 07 10; 24(2):379-390.e6. Zhao Y, Harrison DL, Song Y, Ji J, Huang J, Hui E. PMID: 29996099; PMCID: PMC6093302.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    16. In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Proc Natl Acad Sci U S A. 2017 10 31; 114(44):E9338-E9345. Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD. PMID: 29042512; PMCID: PMC5676914.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    17. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017 03 31; 355(6332):1428-1433. Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD. PMID: 28280247; PMCID: PMC6286077.
      View in: PubMed   Mentions: 708     Fields:    Translation:HumansAnimalsCells
    18. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science. 2016 Apr 29; 352(6285):595-9. Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD. PMID: 27056844; PMCID: PMC4892427.
      View in: PubMed   Mentions: 459     Fields:    Translation:HumansCells
    19. A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores. J Neurosci. 2015 Apr 08; 35(14):5772-80. Chang CW, Hui E, Bai J, Bruns D, Chapman ER, Jackson MB. PMID: 25855187; PMCID: PMC4388931.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    20. Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. Elife. 2014 Feb 25; 3:e01524. Liu H, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE, Chapman ER. PMID: 24569478; PMCID: PMC3930910.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    21. In vitro membrane reconstitution of the T-cell receptor proximal signaling network. Nat Struct Mol Biol. 2014 Feb; 21(2):133-42. Hui E, Vale RD. PMID: 24463463; PMCID: PMC4062301.
      View in: PubMed   Mentions: 81     Fields:    Translation:Cells
    22. Mechanism and function of synaptotagmin-mediated membrane apposition. Nat Struct Mol Biol. 2011 Jun 05; 18(7):813-21. Hui E, Gaffaney JD, Wang Z, Johnson CP, Evans CS, Chapman ER. PMID: 21642967; PMCID: PMC3130839.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    23. Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells. Mol Biol Cell. 2009 Dec; 20(24):5086-95. Zhang Z, Hui E, Chapman ER, Jackson MB. PMID: 19828732; PMCID: PMC2793286.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    24. Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion. Cell. 2009 Aug 21; 138(4):709-21. Hui E, Johnson CP, Yao J, Dunning FM, Chapman ER. PMID: 19703397; PMCID: PMC2758036.
      View in: PubMed   Mentions: 176     Fields:    Translation:AnimalsCells
    25. Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis. J Biol Chem. 2008 Nov 14; 283(46):31763-75. Gaffaney JD, Dunning FM, Wang Z, Hui E, Chapman ER. PMID: 18784080; PMCID: PMC2581593.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    26. Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo. J Neurosci. 2008 Jul 23; 28(30):7458-66. Paddock BE, Striegel AR, Hui E, Chapman ER, Reist NE. PMID: 18650324; PMCID: PMC2949296.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    27. Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. Nat Struct Mol Biol. 2008 Aug; 15(8):827-35. Chicka MC, Hui E, Liu H, Chapman ER. PMID: 18622390; PMCID: PMC2570314.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    28. Synaptotagmin perturbs the structure of phospholipid bilayers. Biochemistry. 2008 Feb 19; 47(7):2143-52. Shahin V, Datta D, Hui E, Henderson RM, Chapman ER, Edwardson JM. PMID: 18205405; PMCID: PMC3095487.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    29. Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I. Biophys J. 2006 Sep 01; 91(5):1767-77. Hui E, Bai J, Chapman ER. PMID: 16782782; PMCID: PMC1544279.
      View in: PubMed   Mentions: 66     Fields:    Translation:Cells
    30. Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5210-4. Hui E, Bai J, Wang P, Sugimori M, Llinas RR, Chapman ER. PMID: 15793006; PMCID: PMC556003.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
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