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Dionicio Siegel

TitleTeacher
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0756
La Jolla CA 92093
Phone858-822-3666
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    Collapse Biography 
    Collapse Awards and Honors
    2012  - 2017National Science Foundation CAREER Award
    2013Aldrich Lecturer, Yale University
    2011College of Natural Sciences Outreach Excellence Award, The University of Texas at Austin
    2010The University of Texas System Regents’ Outstanding Teaching Award
    2005  - 2007Congressionally Directed Medical Research Program Fellow, Memorial Sloan-Kettering Cancer Center
    1998Upjohn-Pharmacia Fellow, California Institute of Technology
    1997  - 1998Institute Fellowship, California Institute of Technology

    Collapse Overview 
    Collapse Overview
    Our group synthesizes molecules with an emphasis on structurally complex compounds with profound biological effects. Natural products provide an ideal medium, providing challenging molecular architectures to enable the training of synthetic chemists as well as drive drug development by generating new chemical leads and promoting the discovery of novel biological targets.

    Through broad collaborative efforts with research groups in different disease areas we optimize compounds that originate in their laboratories for pharmacokinetic and pharmacodynamics properties. We also help prepare novel molecular probes to decipher the mechanisms of action of these compounds.


    Collapse ORNG Applications 
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Debnath A, Nelson AT, Silva-Olivares A, Shibayama M, Siegel D, McKerrow JH. In Vitro Efficacy of Ebselen and BAY 11-7082 AgainstNaegleria fowleri. Front Microbiol. 2018; 9:414. PMID: 29559968.
      View in: PubMed
    2. Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, Arriaga I, Bopp S, Corey VC, Gnädig NF, Coburn-Flynn O, Reimer C, Gupta P, Murithi JM, Moura PA, Fuchs O, Sasaki E, Kim SW, Teng CH, Wang LT, Akidil A, Adjalley S, Willis PA, Siegel D, Tanaseichuk O, Zhong Y, Zhou Y, Llinás M, Ottilie S, Gamo FJ, Lee MCS, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science. 2018 01 12; 359(6372):191-199. PMID: 29326268.
      View in: PubMed
    3. Johnson TC, Siegel D. Directing Stem Cell Fate: The Synthetic Natural Product Connection. Chem Rev. 2017 Sep 27; 117(18):12052-12086. PMID: 28771328.
      View in: PubMed
    4. Johnson TC, Chin MR, Siegel D. Synthetic Route Development for the Laboratory Preparation of Eupalinilide E. J Org Chem. 2017 May 05; 82(9):4640-4653. PMID: 28440078.
      View in: PubMed
    5. Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. J Am Chem Soc. 2017 04 05; 139(13):4943-4947. PMID: 28350171.
      View in: PubMed
    6. Johnson TC, Chin MR, Han T, Shen JP, Rana T, Siegel D. Synthesis of Eupalinilide E, a Promoter of Human Hematopoietic Stem and Progenitor Cell Expansion. J Am Chem Soc. 2016 05 11; 138(18):6068-73. PMID: 27096704.
      View in: PubMed
    7. Cho J, Tremmel L, Rho O, Camelio AM, Siegel D, Slaga TJ, DiGiovanni J. Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Oncotarget. 2015 Nov 17; 6(36):39292-306. PMID: 26513295; PMCID: PMC4770773.
    8. Camelio AM, Johnson TC, Siegel D. Total Synthesis of Celastrol, Development of a Platform to Access Celastroid Natural Products. J Am Chem Soc. 2015 Sep 23; 137(37):11864-7. PMID: 26331410.
      View in: PubMed
    9. Eliasen AM, Christy M, Claussen KR, Besandre R, Thedford RP, Siegel D. Dearomatization Reactions Using Phthaloyl Peroxide. Org Lett. 2015 Sep 18; 17(18):4420-3. PMID: 26333308.
      View in: PubMed
    10. Camelio AM, Liang Y, Eliasen AM, Johnson TC, Yuan C, Schuppe AW, Houk KN, Siegel D. Computational and Experimental Studies of Phthaloyl Peroxide-Mediated Hydroxylation of Arenes Yield a More Reactive Derivative, 4,5-Dichlorophthaloyl Peroxide. J Org Chem. 2015 Aug 21; 80(16):8084-95. PMID: 26200205.
      View in: PubMed
    11. Nelson AT, Camelio AM, Claussen KR, Cho J, Tremmel L, DiGiovanni J, Siegel D. Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties. Bioorg Med Chem Lett. 2015 Oct 01; 25(19):4342-6. PMID: 26259803; PMCID: PMC4835183 [Available on 10/01/16].
    12. Cho J, Rho O, Junco J, Carbajal S, Siegel D, Slaga TJ, DiGiovanni J. Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate. Cancer Prev Res (Phila). 2015 Sep; 8(9):817-25. PMID: 26100520; PMCID: PMC4560654.
    13. Chin MR, Zlotkowski K, Han M, Patel S, Eliasen AM, Axelrod A, Siegel D. Expedited access to vinaxanthone and chemically edited derivatives possessing neuronal regenerative effects through ynone coupling reactions. ACS Chem Neurosci. 2015 Apr 15; 6(4):542-50. PMID: 25615693.
      View in: PubMed
    14. Aggarwal PK, Veron D, Thomas DB, Siegel D, Moeckel G, Kashgarian M, Tufro A. Semaphorin3a promotes advanced diabetic nephropathy. Diabetes. 2015 May; 64(5):1743-59. PMID: 25475434; PMCID: PMC4407856.
    15. Yuan C, Eliasen AM, Camelio AM, Siegel D. Preparation of phenols by phthaloyl peroxide-mediated oxidation of arenes. Nat Protoc. 2014 Nov; 9(11):2624-9. PMID: 25321407.
      View in: PubMed
    16. Eliasen AM, Thedford RP, Claussen KR, Yuan C, Siegel D. A protocol to generate phthaloyl peroxide in flow for the hydroxylation of arenes. Org Lett. 2014 Jul 18; 16(14):3628-31. PMID: 24988535.
      View in: PubMed
    17. Johnson T, Siegel D. Complanadine A, a selective agonist for the Mas-related G protein-coupled receptor X2. Bioorg Med Chem Lett. 2014 Aug 01; 24(15):3512-5. PMID: 24930830.
      View in: PubMed
    18. Zlotkowski K, Eliasen AM, Mitra A, Siegel D. Small-molecule mechanism of action studies in Caenorhabditis elegans. Chembiochem. 2013 Nov 25; 14(17):2338-44. PMID: 24123757.
      View in: PubMed
    19. Yuan C, Liang Y, Hernandez T, Berriochoa A, Houk KN, Siegel D. Metal-free oxidation of aromatic carbon-hydrogen bonds through a reverse-rebound mechanism. Nature. 2013 Jul 11; 499(7457):192-6. PMID: 23846658.
      View in: PubMed
    20. Yuan C, Chang CT, Siegel D. Syntheses of (+)-complanadine A and lycodine derivatives by regioselective [2 + 2 + 2] cycloadditions. J Org Chem. 2013 Jun 07; 78(11):5647-68. PMID: 23635039.
      View in: PubMed
    21. Zlotkowski K, Pierce-Shimomura J, Siegel D. Small-molecule-mediated axonal branching in Caenorhabditis elegans. Chembiochem. 2013 Feb 11; 14(3):307-10. PMID: 23362121; PMCID: PMC4470382.
    22. Axelrod A, Eliasen AM, Chin MR, Zlotkowski K, Siegel D. Syntheses of xanthofulvin and vinaxanthone, natural products enabling spinal cord regeneration. Angew Chem Int Ed Engl. 2013 Mar 18; 52(12):3421-4. PMID: 23086682.
      View in: PubMed
    23. Cheng X, Harzdorf N, Khaing Z, Kang D, Camelio AM, Shaw T, Schmidt CE, Siegel D. Neuronal growth promoting sesquiterpene-neolignans; syntheses and biological studies. Org Biomol Chem. 2012 Jan 14; 10(2):383-93. PMID: 22083452.
      View in: PubMed
    24. Piasecki SK, Taylor CA, Detelich JF, Liu J, Zheng J, Komsoukaniants A, Siegel D, Keatinge-Clay AT. Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks. Chem Biol. 2011 Oct 28; 18(10):1331-40. PMID: 22035802.
      View in: PubMed
    25. Vidal-Gadea A, Topper S, Young L, Crisp A, Kressin L, Elbel E, Maples T, Brauner M, Erbguth K, Axelrod A, Gottschalk A, Siegel D, Pierce-Shimomura JT. Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin. Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17504-9. PMID: 21969584; PMCID: PMC3198358.
    26. Khaing Z, Kang D, Camelio AM, Schmidt CE, Siegel D. Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol. Bioorg Med Chem Lett. 2011 Aug 15; 21(16):4808-12. PMID: 21757342.
      View in: PubMed
    27. Zhang M, Cho EJ, Burstein G, Siegel D, Zhang Y. Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor. ACS Chem Biol. 2011 May 20; 6(5):511-9. PMID: 21348431; PMCID: PMC4814157.
    28. Camelio AM, Barton T, Guo F, Shaw T, Siegel D. Hydroxyl-directed cyclizations of 1,6-enynes. Org Lett. 2011 Mar 18; 13(6):1517-9. PMID: 21314167.
      View in: PubMed
    29. Yuan C, Chang CT, Axelrod A, Siegel D. Synthesis of (+)-complanadine A, an inducer of neurotrophic factor excretion. J Am Chem Soc. 2010 May 05; 132(17):5924-5. PMID: 20387896.
      View in: PubMed
    30. Cheng X, Harzdorf NL, Shaw T, Siegel D. Biomimetic syntheses of the neurotrophic natural products caryolanemagnolol and clovanemagnolol. Org Lett. 2010 Mar 19; 12(6):1304-7. PMID: 20158263.
      View in: PubMed
    31. Sun C, Wang Q, Brubaker JD, Wright PM, Lerner CD, Noson K, Charest M, Siegel D, Wang YM, Myers AG. A robust platform for the synthesis of new tetracycline antibiotics. J Am Chem Soc. 2008 Dec 31; 130(52):17913-27. PMID: 19053822; PMCID: PMC2681267.
    32. Tsukano C, Siegel D, Danishefsky SJ. Differentiation of nonconventional "carbanions"-the total synthesis of nemorosone and clusianone. Angew Chem Int Ed Engl. 2007; 46(46):8840-4. PMID: 17935090.
      View in: PubMed
    33. Liu H, Siegel D, Danishefsky SJ. Studies directed toward the synthesis of terreulactone A: rapid construction of the A, B, C rings. Org Lett. 2006 Feb 02; 8(3):423-5. PMID: 16435850.
      View in: PubMed
    34. Siegel D, Danishefsky SJ. Total synthesis of garsubellin A. J Am Chem Soc. 2006 Feb 01; 128(4):1048-9. PMID: 16433500.
      View in: PubMed
    35. Charest MG, Siegel D, Myers AG. Synthesis of (-)-tetracycline. J Am Chem Soc. 2005 Jun 15; 127(23):8292-3. PMID: 15941256.
      View in: PubMed
    36. Charest MG, Lerner CD, Brubaker JD, Siegel D, Myers AG. A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics. Science. 2005 Apr 15; 308(5720):395-8. PMID: 15831754.
      View in: PubMed
    37. Myers AG, Siegel D, Buzard DJ, Charest MG. Synthesis of a broad array of highly functionalized, enantiomerically pure cyclohexanecarboxylic acid derivatives by microbial dihydroxylation of benzoic acid and subsequent oxidative and rearrangement reactions. Org Lett. 2001 Sep 06; 3(18):2923-6. PMID: 11529791.
      View in: PubMed
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