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Cryo-EM Analysis of the Effect of Seeding with Brain-derived Aβ Amyloid Fibrils. J Mol Biol. 2024 02 15; 436(4):168422.
Pfeiffer PB, Ugrina M, Schwierz N, Sigurdson CJ, Schmidt M, Fändrich M. PMID: 38158175.
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Translation:
Humans
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Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection. PLoS Pathog. 2023 09; 19(9):e1011487.
Aguilar-Calvo P, Malik A, Sandoval DR, Barback C, Orrù CD, Standke HG, Thomas OR, Dwyer CA, Pizzo DP, Bapat J, Soldau K, Ogawa R, Riley MB, Nilsson KPR, Kraus A, Caughey B, Iliff JJ, Vera DR, Esko JD, Sigurdson CJ. PMID: 37747931; PMCID: PMC10586673.
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Translation:
AnimalsCells
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TDP43 pathology in chronic traumatic encephalopathy retinas. Acta Neuropathol Commun. 2023 09 22; 11(1):152.
Phansalkar R, Goodwill VS, Nirschl JJ, De Lillo C, Choi J, Spurlock E, Coughlin DG, Pizzo D, Sigurdson CJ, Hiniker A, Alvarez VE, Mckee AC, Lin JH. PMID: 37737191; PMCID: PMC10515050.
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Translation:
Humans
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Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration. J Neurosci. 2023 05 24; 43(21):3970-3984.
Lawrence JA, Aguilar-Calvo P, Ojeda-Juárez D, Khuu H, Soldau K, Pizzo DP, Wang J, Malik A, Shay TF, Sullivan EE, Aulston B, Song SM, Callender JA, Sanchez H, Geschwind MD, Roy S, Rissman RA, Trejo J, Tanaka N, Wu C, Chen X, Patrick GN, Sigurdson CJ. PMID: 37019623; PMCID: PMC10219035.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Structural consequences of sequence variation in mammalian prion β2α2 loop segments. Front Neurosci. 2022; 16:960322.
Glynn C, Hernandez E, Gallagher-Jones M, Miao J, Sigurdson CJ, Rodriguez JA. PMID: 36389229; PMCID: PMC9645039.
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Differences in Age-related Retinal and Cortical Atrophy Rates in Multiple Sclerosis. Neurology. 2022 10 11; 99(15):e1685-e1693.
Cordano C, Nourbakhsh B, Yiu HH, Papinutto N, Caverzasi E, Abdelhak A, Oertel FC, Beaudry-Richard A, Santaniello A, Sacco S, Bennett DJ, Gomez A, Sigurdson CJ, Hauser SL, Magliozzi R, Cree BAC, Henry RG, Green AJ. PMID: 36038272; PMCID: PMC9559941.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus. Neurobiol Dis. 2022 10 01; 172:105834.
Ojeda-Juárez D, Lawrence JA, Soldau K, Pizzo DP, Wheeler E, Aguilar-Calvo P, Khuu H, Chen J, Malik A, Funk G, Nam P, Sanchez H, Geschwind MD, Wu C, Yeo GW, Chen X, Patrick GN, Sigurdson CJ. PMID: 35905927; PMCID: PMC10080886.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Minimal change prion retinopathy: Morphometric comparison of retinal and brain prion deposits in Creutzfeldt-Jakob disease. Exp Eye Res. 2022 09; 222:109172.
Goodwill VS, Dryden I, Choi J, De Lillo C, Soldau K, Llibre-Guerra J, Sanchez H, Sigurdson CJ, Lin JH. PMID: 35803332; PMCID: PMC9946801.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Cellular prion protein in human plasma-derived extracellular vesicles promotes neurite outgrowth via the NMDA receptor-LRP1 receptor system. J Biol Chem. 2022 03; 298(3):101642.
Gonias SL, Banki MA, Azmoon P, Romero HK, Sigurdson CJ, Mantuano E, Campana WM. PMID: 35090893; PMCID: PMC8861162.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Noninvasive Antemortem Detection of Retinal Prions by a Fluorescent Tracer. J Alzheimers Dis. 2022; 88(3):1137-1145.
Aguilar-Calvo P, Sevillano AM, Rasool S, Cao KJ, Randolph LM, Rissman RA, Sarraf ST, Yang J, Sigurdson CJ. PMID: 35754278; PMCID: PMC10080909.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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A Soluble PrPC Derivative and Membrane-Anchored PrPC in Extracellular Vesicles Attenuate Innate Immunity by Engaging the NMDA-R/LRP1 Receptor Complex. J Immunol. 2022 01 01; 208(1):85-96.
Mantuano E, Azmoon P, Banki MA, Sigurdson CJ, Campana WM, Gonias SL. PMID: 34810220; PMCID: PMC8702456.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease. J Biol Chem. 2021 11; 297(5):101267.
Liu H, Kim C, Haldiman T, Sigurdson CJ, Nyström S, Nilsson KPR, Cohen ML, Wisniewski T, Hammarström P, Safar JG. PMID: 34599965; PMCID: PMC8531671.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina. Transl Vis Sci Technol. 2021 06 01; 10(7):5.
Cao KJ, Kim JH, Kroeger H, Gaffney PM, Lin JH, Sigurdson CJ, Yang J. PMID: 34096989; PMCID: PMC8185402.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Scaling analysis reveals the mechanism and rates of prion replication in vivo. Nat Struct Mol Biol. 2021 04; 28(4):365-372.
Meisl G, Kurt T, Condado-Morales I, Bett C, Sorce S, Nuvolone M, Michaels TCT, Heinzer D, Avar M, Cohen SIA, Hornemann S, Aguzzi A, Dobson CM, Sigurdson CJ, Knowles TPJ. PMID: 33767451; PMCID: PMC8922999.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimals
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Short and sweet: How glycans impact prion conversion, cofactor interactions, and cross-species transmission. PLoS Pathog. 2021 01; 17(1):e1009123.
Aguilar-Calvo P, Callender JA, Sigurdson CJ. PMID: 33444414; PMCID: PMC7808606.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. J Neuropathol Exp Neurol. 2020 11 01; 79(11):1141-1146.
Asher DM, Belay E, Bigio E, Brandner S, Brubaker SA, Caughey B, Clark B, Damon I, Diamond M, Freund M, Hyman BT, Jucker M, Keene CD, Lieberman AP, Mackiewicz M, Montine TJ, Morgello S, Phelps C, Safar J, Schneider JA, Schonberger LB, Sigurdson C, Silverberg N, Trojanowski JQ, Frosch MP. PMID: 33000167; PMCID: PMC7577514.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
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A soluble derivative of PrPC activates cell-signaling and regulates cell physiology through LRP1 and the NMDA receptor. J Biol Chem. 2020 10 09; 295(41):14178-14188.
Mantuano E, Azmoon P, Banki MA, Lam MS, Sigurdson CJ, Gonias SL. PMID: 32788217; PMCID: PMC7549038.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease. Neurobiol Dis. 2020 08; 142:104955.
Callender JA, Sevillano AM, Soldau K, Kurt TD, Schumann T, Pizzo DP, Altmeppen H, Glatzel M, Esko JD, Sigurdson CJ. PMID: 32454127; PMCID: PMC7425694.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease. J Clin Invest. 2020 03 02; 130(3):1350-1362.
Sevillano AM, Aguilar-Calvo P, Kurt TD, Lawrence JA, Soldau K, Nam TH, Schumann T, Pizzo DP, Nyström S, Choudhury B, Altmeppen H, Esko JD, Glatzel M, Nilsson KPR, Sigurdson CJ. PMID: 31985492; PMCID: PMC7269597.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions. Acta Neuropathol. 2020 03; 139(3):527-546.
Aguilar-Calvo P, Sevillano AM, Bapat J, Soldau K, Sandoval DR, Altmeppen HC, Linsenmeier L, Pizzo DP, Geschwind MD, Sanchez H, Appleby BS, Cohen ML, Safar JG, Edland SD, Glatzel M, Nilsson KPR, Esko JD, Sigurdson CJ. PMID: 31673874; PMCID: PMC7036335.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
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Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue. Nat Commun. 2019 10 29; 10(1):4760.
Kollmer M, Close W, Funk L, Rasmussen J, Bsoul A, Schierhorn A, Schmidt M, Sigurdson CJ, Jucker M, Fändrich M. PMID: 31664019; PMCID: PMC6820800.
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PubMed Mentions:
216 Fields:
Translation:
Humans
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Recent advances on the molecular pathogenesis of prion diseases. Brain Pathol. 2019 03; 29(2):245-247.
Glatzel M, Sigurdson CJ. PMID: 30588674; PMCID: PMC8028283.
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HumansAnimals
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Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease. Acta Neuropathol. 2019 04; 137(4):585-598.
Kraus A, Saijo E, Metrick MA, Newell K, Sigurdson CJ, Zanusso G, Ghetti B, Caughey B. PMID: 30570675; PMCID: PMC6426988.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimals
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Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients. mBio. 2018 11 20; 9(6).
Orrù CD, Soldau K, Cordano C, Llibre-Guerra J, Green AJ, Sanchez H, Groveman BR, Edland SD, Safar JG, Lin JH, Caughey B, Geschwind MD, Sigurdson CJ. PMID: 30459197; PMCID: PMC6247090.
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PubMed Mentions:
31 Fields:
Translation:
Humans
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Cellular and Molecular Mechanisms of Prion Disease. Annu Rev Pathol. 2019 01 24; 14:497-516.
Sigurdson CJ, Bartz JC, Glatzel M. PMID: 30355150; PMCID: PMC9071098.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimals
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Generation of novel neuroinvasive prions following intravenous challenge. Brain Pathol. 2018 11; 28(6):999-1011.
Aguilar-Calvo P, Bett C, Sevillano AM, Kurt TD, Lawrence J, Soldau K, Hammarström P, Nilsson KPR, Sigurdson CJ. PMID: 29505163; PMCID: PMC6123309.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Solvation-Guided Design of Fluorescent Probes for Discrimination of Amyloids. Sci Rep. 2018 05 03; 8(1):6950.
Cao KJ, Elbel KM, Cifelli JL, Cirera J, Sigurdson CJ, Paesani F, Theodorakis EA, Yang J. PMID: 29725045; PMCID: PMC5934448.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Electron microscopic and confocal laser microscopy analysis of amyloid plaques in chronic wasting disease transmitted to transgenic mice. Prion. 2017 11 02; 11(6):431-439.
Sikorska B, Gajos A, Bogucki A, Zielonka E, Sigurdson C, Liberski PP. PMID: 29105545; PMCID: PMC5786356.
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HumansAnimals
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Asparagine and glutamine ladders promote cross-species prion conversion. J Biol Chem. 2017 11 17; 292(46):19076-19086.
Kurt TD, Aguilar-Calvo P, Jiang L, Rodriguez JA, Alderson N, Eisenberg DS, Sigurdson CJ. PMID: 28931606; PMCID: PMC5704488.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Enhanced neuroinvasion by smaller, soluble prions. Acta Neuropathol Commun. 2017 04 21; 5(1):32.
Bett C, Lawrence J, Kurt TD, Orru C, Aguilar-Calvo P, Kincaid AE, Surewicz WK, Caughey B, Wu C, Sigurdson CJ. PMID: 28431576; PMCID: PMC5399838.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Post-translational modifications in PrP expand the conformational diversity of prions in vivo. Sci Rep. 2017 03 08; 7:43295.
Aguilar-Calvo P, Xiao X, Bett C, Eraña H, Soldau K, Castilla J, Nilsson KP, Surewicz WK, Sigurdson CJ. PMID: 28272426; PMCID: PMC5341109.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines. Pathobiol Aging Age Relat Dis. 2016; 6:32397.
Keene CD, Darvas M, Kraemer B, Liggitt D, Sigurdson C, Ladiges W. PMID: 27317189; PMCID: PMC4912600.
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PubMed Mentions:
8
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Polymorphism of Amyloid Fibrils In Vivo. Angew Chem Int Ed Engl. 2016 Apr 04; 55(15):4822-5.
Annamalai K, Gührs KH, Koehler R, Schmidt M, Michel H, Loos C, Gaffney PM, Sigurdson CJ, Hegenbart U, Schönland S, Fändrich M. PMID: 26954430; PMCID: PMC4864496.
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PubMed Mentions:
53 Fields:
Translation:
Cells
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Cross-species transmission of CWD prions. Prion. 2016; 10(1):83-91.
Kurt TD, Sigurdson CJ. PMID: 26809254; PMCID: PMC4981193.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222.
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, et al. PMID: 26799652; PMCID: PMC4835977.
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PubMed Mentions:
2775 Fields:
Translation:
HumansAnimals
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Systemic Amyloid A Amyloidosis in Island Foxes (Urocyon littoralis): Severity and Risk Factors. Vet Pathol. 2016 May; 53(3):637-47.
Gaffney PM, Witte C, Clifford DL, Imai DM, O'Brien TD, Trejo M, Liberta F, Annamalai K, Fändrich M, Masliah E, Munson L, Sigurdson CJ. PMID: 26419399; PMCID: PMC4871602.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates. Chemistry. 2015 Oct 19; 21(43):15133-7.
Shirani H, Linares M, Sigurdson CJ, Lindgren M, Norman P, Nilsson KP. PMID: 26388448; PMCID: PMC4641461.
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PubMed Mentions:
32 Fields:
Translation:
Humans
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Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Jun; 125(6):2548.
Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. PMID: 25961458; PMCID: PMC4497774.
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PubMed Mentions:
13 Fields:
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Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death. Am J Pathol. 2015 Jul; 185(7):1800-8.
Hiramatsu N, Chiang WC, Kurt TD, Sigurdson CJ, Lin JH. PMID: 25956028; PMCID: PMC4484218.
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PubMed Mentions:
98 Fields:
Translation:
HumansAnimalsCells
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Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Apr; 125(4):1485-96.
Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. PMID: 25705888; PMCID: PMC4396485.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes. PLoS One. 2014; 9(11):e113765.
Gaffney PM, Imai DM, Clifford DL, Ghassemian M, Sasik R, Chang AN, O'Brien TD, Coppinger J, Trejo M, Masliah E, Munson L, Sigurdson C. PMID: 25429466; PMCID: PMC4245998.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats. FASEB J. 2015 Mar; 29(3):911-9.
Gaffney PM, Barr B, Rowe JD, Bett C, Drygiannakis I, Giannitti F, Trejo M, Ghassemian M, Martin P, Masliah E, Sigurdson CJ. PMID: 25422367; PMCID: PMC6137862.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands. Prion. 2014; 8(4):319-29.
Magnusson K, Simon R, Sjölander D, Sigurdson CJ, Hammarström P, Nilsson KP. PMID: 25495506; PMCID: PMC4601348.
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PubMed Mentions:
39 Fields:
Translation:
Animals
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A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the β2-α2 loop of PrPC. J Biol Chem. 2014 Apr 11; 289(15):10660-10667.
Kurt TD, Jiang L, Bett C, Eisenberg D, Sigurdson CJ. PMID: 24596090; PMCID: PMC4036184.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC. J Neurosci. 2014 Jan 15; 34(3):1022-7.
Kurt TD, Bett C, Fernández-Borges N, Joshi-Barr S, Hornemann S, Rülicke T, Castilla J, Wüthrich K, Aguzzi A, Sigurdson CJ. PMID: 24431459; PMCID: PMC3891945.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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De novo prion aggregates trigger autophagy in skeletal muscle. J Virol. 2014 Feb; 88(4):2071-82.
Joshi-Barr S, Bett C, Chiang WC, Trejo M, Goebel HH, Sikorska B, Liberski P, Raeber A, Lin JH, Masliah E, Sigurdson CJ. PMID: 24307586; PMCID: PMC3911572.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates. Chemistry. 2013 Jul 29; 19(31):10179-92.
Klingstedt T, Shirani H, Åslund KO, Cairns NJ, Sigurdson CJ, Goedert M, Nilsson KP. PMID: 23780508; PMCID: PMC3884759.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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Defining the conformational features of anchorless, poorly neuroinvasive prions. PLoS Pathog. 2013; 9(4):e1003280.
Bett C, Kurt TD, Lucero M, Trejo M, Rozemuller AJ, Kong Q, Nilsson KP, Masliah E, Oldstone MB, Sigurdson CJ. PMID: 23637596; PMCID: PMC3630170.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
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Mucosal transmission and pathogenesis of chronic wasting disease in ferrets. J Gen Virol. 2013 Feb; 94(Pt 2):432-442.
Perrott MR, Sigurdson CJ, Mason GL, Hoover EA. PMID: 23100363; PMCID: PMC3709615.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsPHPublic Health
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Aminonaphthalene 2-cyanoacrylate (ANCA) probes fluorescently discriminate between amyloid-β and prion plaques in brain. J Am Chem Soc. 2012 Oct 24; 134(42):17338-41.
Cao K, Farahi M, Dakanali M, Chang WM, Sigurdson CJ, Theodorakis EA, Yang J. PMID: 22866977; PMCID: PMC3480552.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus). PLoS One. 2012; 7(6):e39055.
Mitchell GB, Sigurdson CJ, O'Rourke KI, Algire J, Harrington NP, Walther I, Spraker TR, Balachandran A. PMID: 22723928; PMCID: PMC3377593.
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PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
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Structure of the β2-α2 loop and interspecies prion transmission. FASEB J. 2012 Jul; 26(7):2868-76.
Bett C, Fernández-Borges N, Kurt TD, Lucero M, Nilsson KP, Castilla J, Sigurdson CJ. PMID: 22490928; PMCID: PMC3382101.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Prion infection promotes extensive accumulation of α-synuclein in aged human α-synuclein transgenic mice. Prion. 2012 Apr-Jun; 6(2):184-90.
Masliah E, Rockenstein E, Inglis C, Adame A, Bett C, Lucero M, Sigurdson CJ. PMID: 22460692; PMCID: PMC3366356.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimals
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PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP. PLoS Pathog. 2012; 8(3):e1002547.
Sajnani G, Silva CJ, Ramos A, Pastrana MA, Onisko BC, Erickson ML, Antaki EM, Dynin I, Vázquez-Fernández E, Sigurdson CJ, Carter JM, Requena JR. PMID: 22396643; PMCID: PMC3291653.
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PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
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Biochemical properties of highly neuroinvasive prion strains. PLoS Pathog. 2012 Feb; 8(2):e1002522.
Bett C, Joshi-Barr S, Lucero M, Trejo M, Liberski P, Kelly JW, Masliah E, Sigurdson CJ. PMID: 22319450; PMCID: PMC3271082.
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PubMed Mentions:
47 Fields:
Translation:
Animals
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Spongiform encephalopathy in transgenic mice expressing a point mutation in the β2-α2 loop of the prion protein. J Neurosci. 2011 Sep 28; 31(39):13840-7.
Sigurdson CJ, Joshi-Barr S, Bett C, Winson O, Manco G, Schwarz P, Rülicke T, Nilsson KP, Margalith I, Raeber A, Peretz D, Hornemann S, Wüthrich K, Aguzzi A. PMID: 21957246; PMCID: PMC3205959.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Evidence for distinct chronic wasting disease (CWD) strains in experimental CWD in ferrets. J Gen Virol. 2012 Jan; 93(Pt 1):212-221.
Perrott MR, Sigurdson CJ, Mason GL, Hoover EA. PMID: 21918005; PMCID: PMC3352335.
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PubMed Mentions:
33 Fields:
Translation:
Animals
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ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue. ACS Chem Neurosci. 2011 May 18; 2(5):249-255.
Chang WM, Dakanali M, Capule CC, Sigurdson CJ, Yang J, Theodorakis EA. PMID: 21743829; PMCID: PMC3129977.
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PubMed Mentions:
28 Fields:
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Tracking protein aggregate interactions. Prion. 2011 Apr-Jun; 5(2):52-5.
Sigurdson CJ, Bartz JC, Nilsson KP. PMID: 21597336; PMCID: PMC3166500.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Sheep with scrapie and mastitis transmit infectious prions through the milk. J Virol. 2011 Jan; 85(2):1136-9.
Ligios C, Cancedda MG, Carta A, Santucciu C, Maestrale C, Demontis F, Saba M, Patta C, DeMartini JC, Aguzzi A, Sigurdson CJ. PMID: 21084475; PMCID: PMC3020009.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCellsPHPublic Health
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PubMed Mentions:
150 Fields:
Translation:
HumansAnimalsCells
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Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. J Proteome Res. 2010 Oct 01; 9(10):5002-24.
Wegrzyn JL, Bark SJ, Funkelstein L, Mosier C, Yap A, Kazemi-Esfarjani P, La Spada AR, Sigurdson C, O'Connor DT, Hook V. PMID: 20695487; PMCID: PMC2996463.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Prion strain interactions are highly selective. J Neurosci. 2010 Sep 08; 30(36):12094-102.
Nilsson KP, Joshi-Barr S, Winson O, Sigurdson CJ. PMID: 20826672; PMCID: PMC2951977.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein. J Gen Virol. 2010 Oct; 91(Pt 10):2651-7.
Sandberg MK, Al-Doujaily H, Sigurdson CJ, Glatzel M, O'Malley C, Powell C, Asante EA, Linehan JM, Brandner S, Wadsworth JD, Collinge J. PMID: 20610667; PMCID: PMC3052602.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimals
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A molecular switch controls interspecies prion disease transmission in mice. J Clin Invest. 2010 Jul; 120(7):2590-9.
Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Fernández-Borges N, Schwarz P, Castilla J, Wüthrich K, Aguzzi A. PMID: 20551516; PMCID: PMC2898603.
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PubMed Mentions:
79 Fields:
Translation:
Animals
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Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chem Biol. 2009 Aug 21; 4(8):673-84.
Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, Aguzzi A, Hammarström P, Nilsson KP. PMID: 19624097; PMCID: PMC2886514.
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PubMed Mentions:
115 Fields:
Translation:
HumansAnimalsCells
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Bacterial colitis increases susceptibility to oral prion disease. J Infect Dis. 2009 Jan 15; 199(2):243-52.
Sigurdson CJ, Heikenwalder M, Manco G, Barthel M, Schwarz P, Stecher B, Krautler NJ, Hardt WD, Seifert B, MacPherson AJ, Corthesy I, Aguzzi A. PMID: 19072552; PMCID: PMC2822447.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity. 2008 Dec 19; 29(6):998-1008.
Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A. PMID: 19100703.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):304-9.
Sigurdson CJ, Nilsson KP, Hornemann S, Heikenwalder M, Manco G, Schwarz P, Ott D, Rülicke T, Liberski PP, Julius C, Falsig J, Stitz L, Wüthrich K, Aguzzi A. PMID: 19073920; PMCID: PMC2629180.
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PubMed Mentions:
107 Fields:
Translation:
AnimalsCells
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The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS One. 2008; 3(12):e3872.
Polymenidou M, Moos R, Scott M, Sigurdson C, Shi YZ, Yajima B, Hafner-Bratkovic I, Jerala R, Hornemann S, Wuthrich K, Bellon A, Vey M, Garen G, James MN, Kav N, Aguzzi A. PMID: 19060956; PMCID: PMC2592702.
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PubMed Mentions:
100 Fields:
Translation:
HumansAnimalsCells
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A prion disease of cervids: chronic wasting disease. Vet Res. 2008 Jul-Aug; 39(4):41.
Sigurdson CJ. PMID: 18381058.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimals
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Experimental chronic wasting disease (CWD) in the ferret. J Comp Pathol. 2008 May; 138(4):189-96.
Sigurdson CJ, Mathiason CK, Perrott MR, Eliason GA, Spraker TR, Glatzel M, Manco G, Bartz JC, Miller MW, Hoover EA. PMID: 18387626.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Molecular mechanisms of prion pathogenesis. Annu Rev Pathol. 2008; 3:11-40.
Aguzzi A, Sigurdson C, Heikenwaelder M. PMID: 18233951.
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PubMed Mentions:
170 Fields:
Translation:
HumansAnimals
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Prion strain discrimination using luminescent conjugated polymers. Nat Methods. 2007 Dec; 4(12):1023-30.
Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Polymenidou M, Schwarz P, Leclerc M, Hammarström P, Wüthrich K, Aguzzi A. PMID: 18026110.
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PubMed Mentions:
95 Fields:
Translation:
Animals
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Chronic wasting disease. Biochim Biophys Acta. 2007 Jun; 1772(6):610-8.
Sigurdson CJ, Aguzzi A. PMID: 17223321; PMCID: PMC2680674.
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PubMed Mentions:
48 Fields:
Translation:
Animals
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Infectious prions in the saliva and blood of deer with chronic wasting disease. Science. 2006 Oct 06; 314(5796):133-6.
Mathiason CK, Powers JG, Dahmes SJ, Osborn DA, Miller KV, Warren RJ, Mason GL, Hays SA, Hayes-Klug J, Seelig DM, Wild MA, Wolfe LL, Spraker TR, Miller MW, Sigurdson CJ, Telling GC, Hoover EA. PMID: 17023660.
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PubMed Mentions:
222 Fields:
Translation:
Animals
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Strain fidelity of chronic wasting disease upon murine adaptation. J Virol. 2006 Dec; 80(24):12303-11.
Sigurdson CJ, Manco G, Schwarz P, Liberski P, Hoover EA, Hornemann S, Polymenidou M, Miller MW, Glatzel M, Aguzzi A. PMID: 17020952; PMCID: PMC1676299.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Prions in skeletal muscles of deer with chronic wasting disease. Science. 2006 Feb 24; 311(5764):1117.
Angers RC, Browning SR, Seward TS, Sigurdson CJ, Miller MW, Hoover EA, Telling GC. PMID: 16439622.
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PubMed Mentions:
93 Fields:
Translation:
HumansAnimals
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PrPSc in mammary glands of sheep affected by scrapie and mastitis. Nat Med. 2005 Nov; 11(11):1137-8.
Ligios C, Sigurdson CJ, Santucciu C, Carcassola G, Manco G, Basagni M, Maestrale C, Cancedda MG, Madau L, Aguzzi A. PMID: 16270061.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Comment on "Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy". Vet Pathol. 2005 Jan; 42(1):107.
Sigurdson C, Glatzel M, Aguzzi A. PMID: 15657284.
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PubMed Mentions: Fields:
Translation:
Animals
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Reconstructing prions: fibril assembly from simple yeast to complex mammals. Neurodegener Dis. 2005; 2(1):1-5.
Sigurdson C, Polymenidou M, Aguzzi A. PMID: 16908997.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Antiprion immunotherapy: to suppress or to stimulate? Nat Rev Immunol. 2004 Sep; 4(9):725-36.
Aguzzi A, Sigurdson CJ. PMID: 15343371.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimals
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Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nat Med. 2004 Feb; 10(2):187-92.
Heikenwalder M, Polymenidou M, Junt T, Sigurdson C, Wagner H, Akira S, Zinkernagel R, Aguzzi A. PMID: 14745443.
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PubMed Mentions:
140 Fields:
Translation:
AnimalsCells
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Other animal prion diseases. Br Med Bull. 2003; 66:199-212.
Sigurdson CJ, Miller MW. PMID: 14522860.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimals
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PrP(CWD) lymphoid cell targets in early and advanced chronic wasting disease of mule deer. J Gen Virol. 2002 Oct; 83(Pt 10):2617-2628.
Sigurdson CJ, Barillas-Mury C, Miller MW, Oesch B, van Keulen LJM, Langeveld JPM, Hoover EA. PMID: 12237446.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy. J Gen Virol. 2002 Oct; 83(Pt 10):2629-2634.
Wild MA, Spraker TR, Sigurdson CJ, O'Rourke KI, Miller MW. PMID: 12237447.
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PubMed Mentions:
26 Fields:
Translation:
Animals
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Globoid cell-like leukodystrophy in a domestic longhaired cat. Vet Pathol. 2002 Jul; 39(4):494-6.
Sigurdson CJ, Basaraba RJ, Mazzaferro EM, Gould DH. PMID: 12126153.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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PrP(CWD) in the myenteric plexus, vagosympathetic trunk and endocrine glands of deer with chronic wasting disease. J Gen Virol. 2001 Oct; 82(Pt 10):2327-2334.
Sigurdson CJ, Spraker TR, Miller MW, Oesch B, Hoover EA. PMID: 11562526.
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PubMed Mentions:
64 Fields:
Translation:
Animals
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Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus). J Gen Virol. 1999 Oct; 80 ( Pt 10):2757-2764.
Sigurdson CJ, Williams ES, Miller MW, Spraker TR, O'Rourke KI, Hoover EA. PMID: 10573172.
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PubMed Mentions:
126 Fields:
Translation:
Animals
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Association of excess sulfur intake and an increase in hydrogen sulfide concentrations in the ruminal gas cap of recently weaned beef calves with polioencephalomalacia. J Am Vet Med Assoc. 1998 Dec 01; 213(11):1599-604, 1571.
Loneragan GH, Gould DH, Callan RJ, Sigurdson CJ, Hamar DW. PMID: 9838961.
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PubMed Mentions:
2 Fields:
Translation:
Animals