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Barbara Parry

Title(s)Senate Emeritus, Psychiatry
SchoolHealth Sciences
Address9500 Gilman Drive #0804
La Jolla CA 92093
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    Biography

    Barbara L. Parry, M.D. is Professor of Psychiatry at the University of California, San Diego (UCSD) where she has served as Director of the Women’s Mood Disorders Clinic of the UCSD Outpatient Psychiatric Services, Director of the Women’s Mental Health Clinic at the San Diego Veterans Administration Healthcare Center and Associate Director of the Medical Student Clerkship in Psychiatry. Before joining the faculty at UCSD in 1985, she did a research fellowship in Clinical Psychobiology at the National Institute of Mental Health in Bethesda, Maryland. She completed a residency in Psychiatry and an internship in Internal Medicine at the University of California, Los Angeles. Her clinical research focus is the chronobiology of mood disorders specific to women: premenstrual, pregnancy/postpartum and menopausal depression. She conducts sleep, light, melatonin and other hormonal studies with the aim of developing non-pharmacological approaches to treatment. Her work is supported by NIH funding, she has authored or co-authored over 280 publications and served on NIH study sections, Data and Safety Monitoring Boards and the editorial boards of the American Journal of Psychiatry, the Journal of Biological Rhythms, the International Journal of Endocrinology and Equilibria, the Journal for Postpartum Psychiatric Illness Research.

    Research Interests

    My research and clinical background is in women’s mood disorders related to the reproductive cycle, and in chronobiology: With regard to my background in women’s mood disorders, as a medical student, I published a manuscript on the biologic basis of oral contraceptive-induced depressions (Mentor: A. John Rush, M.D.); as a psychiatric resident at the University of California, Los Angeles, I initiated, and subsequently published, a study on cerebrospinal fluid and endocrine measures in Premenstrual Dysphoric Disorder-PMDD (Mentor: Robert Gerner, M.D.). I continued my studies of women’s mood disorders at the NIH, expanding into its chronobiological aspects, and for the last 29 years since coming to UCSD have extended the endocrine and chronobiological investigations in PMDD to other depressive disorders related to the reproductive cycle in women (pregnancy, postpartum, menopause). With regard to chronobiology, I did a research fellowship in Clinical Chronobiology at the National Institute of Mental Health (Mentors: Frederick K. Goodwin, M.D., Thomas A. Wehr, M.D. and Norman E. Rosenthal, M.D.), where as a clinical research associate I helped to implement studies primarily of melatonin circadian rhythms and of sleep and light therapies in mood disorders (rapid cycling bipolar illness and seasonal affective disorder) and initiated my own studies on melatonin circadian rhythms, sleep and light therapies in PMDD. Since joining the faculty in the Department of Psychiatry at the University of California, San Diego (UCSD) in 1985, I have extended the studies of melatonin and other hormones (cortisol, thyroid, prolactin, estradiol, progesterone, gonadotrophins) and of sleep and light therapies to not only PMDD, but also to pregnancy, postpartum and menopausal depressive disorders (Collaborators: J. Christian Gillin, M.D., Daniel F. Kripke, M.D., Richard L. Hauger, M.D., Jeffrey A. Elliott, Ph.D., Sonia Ancoli-Israel, Ph.D.). I served on the American Psychiatric Association’s DSM-III-R and DSM-IV committees to develop diagnostic criteria for PMDD (and as a consultant for postpartum mood disorders), the Advisory Panel for the Surgeon General’s Women’s Mental Health Project, the NIH Office of Research for Women’s Health: Planning the Women’s Health Agenda for the 21st Century and the Executive Board of the Marce’ Society, The International Society for the Study and Treatment of Mental Illness during Childbearing. In these areas pertaining to the chronobiology of women’s mood disorders, I have published over 285 publications, maintained a consistent level of funding support through primarily NIH and other sources as PI, served as a reviewer on study sections, special emphasis panels, stimulus package grant applications and Data and Safety Monitoring Boards, and been on the editorial boards of multiple journals including the American Journal of Psychiatry, the Journal of Biological Rhythms, the International Journal of Endocrinology and Postpartum Equilibria: Journal of Postpartum Depression Research.

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    Complementary Chronotherapeutics for Pregnancy and Postpartum Depression
    NIH/NICHD R01HD076476Jul 1, 2013 - Apr 30, 2018
    Role: Principal Investigator
    Alternative Treatments for Premenstrual Dysphoric Disorder
    NIH/NCCIH R01AT007169May 1, 2013 - Apr 30, 2018
    Role: Principal Investigator
    Melatonin in Menopausal Depression
    NIH/NIMH R01MH080159Dec 21, 2007 - Nov 30, 2012
    Role: Principal Investigator
    Biological Rhythms in Postpartum Depression
    NIH/NIMH R01MH070788Aug 19, 2005 - Jul 31, 2011
    Role: Principal Investigator
    Probing Premenstrual Dysphoric Disorder with Light
    NIH/NIMH R01MH063462Sep 19, 2002 - Jun 30, 2007
    Role: Principal Investigator
    MENOPAUSAL DEPRESSION: CHRONOBIOLOGIC BASIS
    NIH/NIMH R01MH059919Apr 1, 2000 - Mar 31, 2006
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Jan 27, 1997 - Nov 30, 2010
    Role: Co-Investigator
    CHRONOBIOLOGIC BASIS OF MOOD DISORDERS IN WOMEN
    NIH/NIMH R01MH051214Feb 15, 1996 - Jan 31, 2000
    Role: Principal Investigator
    CHRONOBIOLOGY OF PREMENSTRUAL SYNDROME
    NIH/NIMH R29MH042831Feb 15, 1989 - Jan 31, 1995
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Towards improving recognition and management of perimenopausal depression. Menopause. 2020 04; 27(4):377-379. Parry BL. PMID: 32108733.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    2. An opportunity to enhance health and well-being in menopausal women: educate their male partners! Menopause. 2019 10; 26(10):1090-1092. Parry BL. PMID: 31568097.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Early versus late wake therapy improves mood more in antepartum versus postpartum depression by differentially altering melatonin-sleep timing disturbances. J Affect Disord. 2019 02 15; 245:608-616. Parry BL, Meliska CJ, Lopez AM, Sorenson DL, Martinez LF, Orff HJ, Hauger RL, Kripke DF. PMID: 30445386.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. A systematic review of cortisol, thyroid-stimulating hormone, and prolactin in peripartum women with major depression. Arch Womens Ment Health. 2018 04; 21(2):149-161. Szpunar MJ, Parry BL. PMID: 29022126.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. For Women With PMDD, Acute Changes in Ovarian Steroids, But Not Enduring Higher Levels, Precipitate Symptoms. Am J Psychiatry. 2017 10 01; 174(10):917-919. Parry BL. PMID: 28965460.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Beneficial effects of aging on mood in healthy postmenopausal women. Menopause. 2017 05; 24(5):475-477. Parry BL. PMID: 28225429.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Spiritual Dimensions of Suicide Prevention. Am J Psychiatry. 2017 04 01; 174(4):398. Parry BL. PMID: 28366088.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Somatic, more than affective, anxiety increases the risk for menopausal hot flashes. Menopause. 2016 09; 23(9):935-7. Parry BL. PMID: 27465712.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Hormonal-stress interactions in precipitating perimenopausal depressive symptoms. Menopause. 2016 Mar; 23(3):236-8. Parry BL. PMID: 26886882.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Rhythms and Blues. J Womens Health (Larchmt). 2016 06; 25(6):563-4. Parry BL. PMID: 26872087.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Differential effect of depression versus thermoregulation in postmenopausal sleep disturbance. Menopause. 2015 Oct; 22(10):1032-4. Parry BL. PMID: 26263284.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Antepartum depression severity is increased during seasonally longer nights: relationship to melatonin and cortisol timing and quantity. Chronobiol Int. 2013 Nov; 30(9):1160-73. Meliska CJ, Martínez LF, López AM, Sorenson DL, Nowakowski S, Kripke DF, Elliott J, Parry BL. PMID: 23998286.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    13. To treat or not to treat perinatal depression with antidepressant medication: effects on infant growth. Am J Psychiatry. 2013 May; 170(5):453-4. Parry BL. PMID: 23511843.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Polysomnographic evaluation of sleep quality and quantitative variables in women as a function of mood, reproductive status, and age. Dialogues Clin Neurosci. 2012 Dec; 14(4):413-24. Orff HJ, Meliska CJ, Lopez A, Martinez F, Sorenson D, Parry BL. PMID: 23393417.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Reduced phase-advance of plasma melatonin after bright morning light in the luteal, but not follicular, menstrual cycle phase in premenstrual dysphoric disorder: an extended study. Chronobiol Int. 2011 May; 28(5):415-24. Parry BL, Meliska CJ, Sorenson DL, Martínez LF, López AM, Elliott JA, Hauger RL. PMID: 21721857.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Sleep and the endocrine brain. Int J Endocrinol. 2010; 2010:967435. Mong JA, Suchecki D, Semba K, Parry BL. PMID: 21747850.
      View in: PubMed   Mentions:
    17. Relationship of morningness-eveningness questionnaire score to melatonin and sleep timing, body mass index and atypical depressive symptoms in peri- and post-menopausal women. Psychiatry Res. 2011 Jun 30; 188(1):88-95. Meliska CJ, Martínez LF, López AM, Sorenson DL, Nowakowski S, Parry BL. PMID: 21237517.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    18. Optimal management of perimenopausal depression. Int J Womens Health. 2010 Aug 09; 2:143-51. Parry BL. PMID: 21072307.
      View in: PubMed   Mentions:
    19. Increased sensitivity to light-induced melatonin suppression in premenstrual dysphoric disorder. Chronobiol Int. 2010 Aug; 27(7):1438-53. Parry BL, Meliska CJ, Sorenson DL, Lopez A, Martínez LF, Hauger RL, Elliott JA. PMID: 20795885.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. Weak evidence of bright light effects on human LH and FSH. J Circadian Rhythms. 2010 May 11; 8:5. Kripke DF, Elliott JA, Youngstedt SD, Parry BL, Hauger RL, Rex KM. PMID: 20459826.
      View in: PubMed   Mentions:
    21. Assessing risk and benefit: to treat or not to treat major depression during pregnancy with antidepressant medication. Am J Psychiatry. 2009 May; 166(5):512-4. Parry BL. PMID: 19411375.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Sleep and menopause. Curr Neurol Neurosci Rep. 2009 Mar; 9(2):165-72. Nowakowski S, Meliska CJ, Martinez LF, Parry BL. PMID: 19268040.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    23. Plasma melatonin circadian rhythm disturbances during pregnancy and postpartum in depressed women and women with personal or family histories of depression. Am J Psychiatry. 2008 Dec; 165(12):1551-8. Parry BL, Meliska CJ, Sorenson DL, Lopez AM, Martinez LF, Nowakowski S, Elliott JA, Hauger RL, Kripke DF. PMID: 18829869.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    24. Late, but not early, wake therapy reduces morning plasma melatonin: relationship to mood in Premenstrual Dysphoric Disorder. Psychiatry Res. 2008 Oct 30; 161(1):76-86. Parry BL, Meliska CJ, Martínez LF, López AM, Sorenson DL, Hauger RL, Elliott JA. PMID: 18789826.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Measuring melatonin in humans. J Clin Sleep Med. 2008 Feb 15; 4(1):66-9. Benloucif S, Burgess HJ, Klerman EB, Lewy AJ, Middleton B, Murphy PJ, Parry BL, Revell VL. PMID: 18350967.
      View in: PubMed   Mentions: 82     Fields:    Translation:Humans
    26. Perimenopausal depression. Am J Psychiatry. 2008 Jan; 165(1):23-7. Parry BL. PMID: 18178752.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    27. Increased melatonin and delayed offset in menopausal depression: role of years past menopause, follicle-stimulating hormone, sleep end time, and body mass index. J Clin Endocrinol Metab. 2008 Jan; 93(1):54-60. Parry BL, Meliska CJ, Sorenson DL, López AM, Martínez LF, Nowakowski S, Hauger RL, Elliott JA. PMID: 18042653.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    28. Sleep disturbances at menopause are related to sleep disorders and anxiety symptoms. Menopause. 2007 Sep-Oct; 14(5):812-4. Parry BL. PMID: 17667150.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Sleep, rhythms and women's mood. Part II. Menopause. Sleep Med Rev. 2006 Jun; 10(3):197-208. Parry BL, Fernando Martínez L, Maurer EL, López AM, Sorenson D, Meliska CJ. PMID: 16618548.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    30. Sleep, rhythms and women's mood. Part I. Menstrual cycle, pregnancy and postpartum. Sleep Med Rev. 2006 Apr; 10(2):129-44. Parry BL, Martínez LF, Maurer EL, López AM, Sorenson D, Meliska CJ. PMID: 16460973.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    31. Melatonin in mood disorders. World J Biol Psychiatry. 2006; 7(3):138-51. Srinivasan V, Smits M, Spence W, Lowe AD, Kayumov L, Pandi-Perumal SR, Parry B, Cardinali DP. PMID: 16861139.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    32. Local polynomial regression modeling of human plasma melatonin levels. J Biol Rhythms. 2004 Apr; 19(2):164-74. Gamst A, Wolfson T, Parry B. PMID: 15038856.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Menopause: neuroendocrine changes and hormone replacement therapy. J Am Med Womens Assoc (1972). 2004; 59(2):135-45. Parry BL, Meliska CJ, Martinez LF, Basavaraj N, Zirpoli GG, Sorenson D, Maurer EL, Lopez A, Markova K, Gamst A, Wolfson T, Hauger R, Kripke DF. PMID: 15134429.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    34. Light treatment of mood disorders. Dialogues Clin Neurosci. 2003 Dec; 5(4):353-65. Parry BL, Maurer EL. PMID: 22033495.
      View in: PubMed   Mentions: 9     Fields:    
    35. Does estrogen enhance the antidepressant effects of fluoxetine? J Affect Disord. 2003 Oct; 77(1):87-92. Westlund Tam L, Parry BL. PMID: 14550939.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    36. Hormonal basis of mood and postpartum disorders. Curr Womens Health Rep. 2003 Jun; 3(3):230-5. Parry BL, Sorenson DL, Meliska CJ, Basavaraj N, Zirpoli GG, Gamst A, Hauger R. PMID: 12734034.
      View in: PubMed   Mentions:
    37. Measurement of illumination exposure in postpartum women. BMC Psychiatry. 2003 May 13; 3:5. Wang EJ, Kripke DF, Stein MT, Parry BL. PMID: 12744724.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    38. Jet lag: minimizing it's effects with critically timed bright light and melatonin administration. J Mol Microbiol Biotechnol. 2002 Sep; 4(5):463-6. Parry BL. PMID: 12432956.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    39. Effects of a traditional herbal supplement on anxiety in patients with generalized anxiety disorder. J Clin Psychopharmacol. 2002 Aug; 22(4):443-4. Mills PJ, Farag NH, Newton RP, Parry BL. PMID: 12172353.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    40. Clinical practice. Postpartum depression. N Engl J Med. 2002 Jul 18; 347(3):194-9. Wisner KL, Parry BL, Piontek CM. PMID: 12124409.
      View in: PubMed   Mentions: 81     Fields:    Translation:Humans
    41. Autonomic and cardiovascular function in postmenopausal women: the effects of estrogen versus combination therapy. Am J Obstet Gynecol. 2002 May; 186(5):954-61. Farag NH, Nelesen RA, Parry BL, Loredo JS, Dimsdale JE, Mills PJ. PMID: 12015521.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    42. Chronobiological basis of female-specific mood disorders. Neuropsychopharmacology. 2001 Nov; 25(5 Suppl):S102-8. Parry BL, Newton RP. PMID: 11682284.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCTClinical Trials
    43. The role of central serotonergic dysfunction in the aetiology of premenstrual dysphoric disorder: therapeutic implications. CNS Drugs. 2001; 15(4):277-85. Parry BL. PMID: 11463133.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    44. Can critically timed sleep deprivation be useful in pregnancy and postpartum depressions? J Affect Disord. 2000 Nov; 60(3):201-12. Parry BL, Curran ML, Stuenkel CA, Yokimozo M, Tam L, Powell KA, Gillin JC. PMID: 11074109.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    45. Mood disorders and the reproductive cycle. J Gend Specif Med. 2000 Jul-Aug; 3(5):53-8. Parry BL, Haynes P. PMID: 11253256.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    46. Sleep EEG studies during early and late partial sleep deprivation in premenstrual dysphoric disorder and normal control subjects. Psychiatry Res. 1999 Feb 22; 85(2):127-43. Parry BL, Mostofi N, LeVeau B, Nahum HC, Golshan S, Laughlin GA, Gillin JC. PMID: 10220004.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
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