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Arthur Brody

Title(s)Professor In Residence, Psychiatry
SchoolHealth Sciences
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    Collapse Biography 
    Collapse Education and Training
    UCLAResidency1994Department of Psychiatry
    Tufts UniversityM.D.1990School of Medicine
    Vassar CollegeB.A.1986
    Collapse Awards and Honors
    UCLA Department of Psychiatry2009  - 2012Richard Metzner Endowed Chair
    Neuropsychopharmacology2013  - 2015Reviewer Appreciation Award
    VA Clinical Science Research and Development Services  - 2009Certificate of Appreciation
    American Psychiatric Association  - 2008Distinguished Fellow
    Department of Veterans Affairs2003  - 2003Goal Sharing Award
    National Alliance for Research on Schizophrenia and Depression1995  - 1997Daniel X. Freeman Award
    Vassar College1982  - 1986Cum Laude

    Collapse Overview 
    Collapse Overview
    Research and Clinical Interests: Tobacco Use Disorder; Positron Emission Tomography; Treatment of Cigarette Smoking

    Collapse Research 
    Collapse Research Activities and Funding
    Cross-species studies of smoking effects on cognition and neuroinflammation in HIV
    NIH/NIDA R01DA044909Aug 1, 2017 - Jul 31, 2022
    Role: Co-Principal Investigator
    Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    VA I01CX000412Jan 1, 2013 - Dec 31, 2017
    Role: Principal Investigator
    Brain Nicotine Receptor Density &Response to Nicotine Patch
    NIH/NIDA R01DA020872Sep 30, 2005 - Jun 30, 2014
    Role: Principal Investigator
    Treatments for Nicotine Dependence: Brain Mechanisms
    NIH/NIDA R01DA015059Sep 30, 2002 - Aug 31, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zorick T, Okita K, Mandelkern MA, London ED, Brody AL. Effects of Citalopram on Cue-Induced Alcohol Craving and Thalamic D2/3 Dopamine Receptor Availability. Int J Neuropsychopharmacol. 2019 Apr 01; 22(4):286-291. PMID: 30753467.
      View in: PubMed
    2. Brody AL, Gehlbach D, Garcia LY, Enoki R, Hoh C, Vera D, Kotta KK, London ED, Okita K, Nurmi EL, Seaman LC, Mandelkern MA. Effect of overnight smoking abstinence on a marker for microglial activation: a [11C]DAA1106 positron emission tomography study. Psychopharmacology (Berl). 2018 Dec; 235(12):3525-3534. PMID: 30343364.
      View in: PubMed
    3. Brody AL, Hubert R, Enoki R, Garcia LY, Mamoun MS, Okita K, London ED, Nurmi EL, Seaman LC, Mandelkern MA. Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [11C]DAA1106 Positron Emission Tomography Study. Neuropsychopharmacology. 2018 03; 43(4):925. PMID: 29422498.
      View in: PubMed
    4. Brody AL, Hubert R, Enoki R, Garcia LY, Mamoun MS, Okita K, London ED, Nurmi EL, Seaman LC, Mandelkern MA. Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [11C]DAA1106 Positron Emission Tomography Study. Neuropsychopharmacology. 2017 Jul; 42(8):1630-1639. PMID: 28262740.
      View in: PubMed
    5. Sultzer DL, Melrose RJ, Riskin-Jones H, Narvaez TA, Veliz J, Ando TK, Juarez KO, Harwood DG, Brody AL, Mandelkern MA. Cholinergic Receptor Binding in Alzheimer Disease and Healthy Aging: Assessment In Vivo with Positron Emission Tomography Imaging. Am J Geriatr Psychiatry. 2017 Apr; 25(4):342-353. PMID: 28162919.
      View in: PubMed
    6. Brody AL, Zorick T, Hubert R, Hellemann GS, Balali S, Kawasaki SS, Garcia LY, Enoki R, Abraham P, Young P, McCreary C. Combination Extended Smoking Cessation Treatment Plus Home Visits for Smokers With Schizophrenia: A Randomized Controlled Trial. Nicotine Tob Res. 2017 01; 19(1):68-76. PMID: 27613888.
      View in: PubMed
    7. Brody AL, Hubert R, Mamoun MS, Enoki R, Garcia LY, Abraham P, Young P, Mandelkern MA. Nicotinic acetylcholine receptor availability in cigarette smokers: effect of heavy caffeine or marijuana use. Psychopharmacology (Berl). 2016 Sep; 233(17):3249-57. PMID: 27370018.
      View in: PubMed
    8. Dubroff JG, Doot RK, Falcone M, Schnoll RA, Ray R, Tyndale RF, Brody AL, Hou C, Schmitz A, Lerman C. Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism. J Nucl Med. 2015 Nov; 56(11):1724-9. PMID: 26272810.
      View in: PubMed
    9. Brody AL, McClernon FJ. Prediction of smoking cessation with treatment: the emerging contribution of brain imaging research. Neuropsychopharmacology. 2015 May; 40(6):1309-10. PMID: 25868069.
      View in: PubMed
    10. Mamoun M, Bergen AW, Shieh J, Wiggins A, Brody AL. Biomarkers of Response to Smoking Cessation Pharmacotherapies: Progress to Date. CNS Drugs. 2015 May; 29(5):359-69. PMID: 25895022.
      View in: PubMed
    11. Zorick T, Mandelkern MA, Brody AL. A naturalistic study of the association between antidepressant treatment and outcome of smoking cessation treatment. J Clin Psychiatry. 2014 Dec; 75(12):e1433-8. PMID: 25551240.
      View in: PubMed
    12. Brody AL, Okita K, Shieh J, Liang L, Hubert R, Mamoun M, Farahi J, Mandelkern MA. Radiation dosimetry and biodistribution of the translocator protein radiotracer [(11)C]DAA1106 determined with PET/CT in healthy human volunteers. Nucl Med Biol. 2014 Nov-Dec; 41(10):871-5. PMID: 25156039.
      View in: PubMed
    13. Brody AL, Mukhin AG, Mamoun MS, Luu T, Neary M, Liang L, Shieh J, Sugar CA, Rose JE, Mandelkern MA. Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial. JAMA Psychiatry. 2014 Jul 01; 71(7):797-805. PMID: 24850280.
      View in: PubMed
    14. Ray LA, Courtney KE, Ghahremani DG, Miotto K, Brody A, London ED. Varenicline, naltrexone, and their combination for heavy-drinking smokers: preliminary neuroimaging findings. Am J Drug Alcohol Abuse. 2015 Jan; 41(1):35-44. PMID: 24949564.
      View in: PubMed
    15. Ray LA, Courtney KE, Ghahremani DG, Miotto K, Brody A, London ED. Varenicline, low dose naltrexone, and their combination for heavy-drinking smokers: human laboratory findings. Psychopharmacology (Berl). 2014 Oct; 231(19):3843-53. PMID: 24733235.
      View in: PubMed
    16. Storage S, Mandelkern MA, Phuong J, Kozman M, Neary MK, Brody AL. A positive relationship between harm avoidance and brain nicotinic acetylcholine receptor availability. Psychiatry Res. 2013 Dec 30; 214(3):415-21. PMID: 24148908.
      View in: PubMed
    17. Le Foll B, Guranda M, Wilson AA, Houle S, Rusjan PM, Wing VC, Zawertailo L, Busto U, Selby P, Brody AL, George TP, Boileau I. Elevation of dopamine induced by cigarette smoking: novel insights from a [11C]-+-PHNO PET study in humans. Neuropsychopharmacology. 2014 Jan; 39(2):415-24. PMID: 23954846.
      View in: PubMed
    18. Jasinska AJ, Zorick T, Brody AL, Stein EA. Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans. Neuropharmacology. 2014 Sep; 84:111-22. PMID: 23474015.
      View in: PubMed
    19. Jarcho JM, Feier NA, Bert A, Labus JA, Lee M, Stains J, Ebrat B, Groman SM, Tillisch K, Brody AL, London ED, Mandelkern MA, Mayer EA. Diminished neurokinin-1 receptor availability in patients with two forms of chronic visceral pain. Pain. 2013 Jul; 154(7):987-96. PMID: 23582152.
      View in: PubMed
    20. Brody AL, Mukhin AG, Mamoun MS, Kozman M, Phuong J, Neary M, Luu T, Mandelkern MA. Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density. Neuropsychopharmacology. 2013 Jul; 38(8):1548-56. PMID: 23429692.
      View in: PubMed
    21. Brody AL, Mukhin AG, La Charite J, Ta K, Farahi J, Sugar CA, Mamoun MS, Vellios E, Archie M, Kozman M, Phuong J, Arlorio F, Mandelkern MA. Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers. Int J Neuropsychopharmacol. 2013 Jun; 16(5):957-66. PMID: 23171716.
      View in: PubMed
    22. Lotfipour S, Mandelkern M, Alvarez-Estrada M, Brody AL. A single administration of low-dose varenicline saturates a4ß2* nicotinic acetylcholine receptors in the human brain. Neuropsychopharmacology. 2012 Jun; 37(7):1738-48. PMID: 22395733.
      View in: PubMed
    23. Culbertson CS, Shulenberger S, De La Garza R, Newton TF, Brody AL. VIRTUAL REALITY CUE EXPOSURE THERAPY FOR THE TREATMENT OF TOBACCO DEPENDENCE. J Cyber Ther Rehabil. 2012; 5(1):57-64. PMID: 25342999.
      View in: PubMed
    24. Anderson A, Bramen J, Douglas PK, Lenartowicz A, Cho A, Culbertson C, Brody AL, Yuille AL, Cohen MS. Large Sample Group Independent Component Analysis of Functional Magnetic Resonance Imaging Using Anatomical Atlas-Based Reduction and Bootstrapped Clustering. Int J Imaging Syst Technol. 2011 Jun; 21(2):223-231. PMID: 22049263.
      View in: PubMed
    25. Brody AL, Mandelkern MA, London ED, Khan A, Kozman D, Costello MR, Vellios EE, Archie MM, Bascom R, Mukhin AG. Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain. Arch Gen Psychiatry. 2011 Sep; 68(9):953-60. PMID: 21536968.
      View in: PubMed
    26. Lotfipour S, Mandelkern M, Brody AL. Quantitative Molecular Imaging of Neuronal Nicotinic Acetylcholine Receptors in the Human Brain with A-85380 Radiotracers. Curr Med Imaging Rev. 2011 May 01; 7(2):107-112. PMID: 22773924.
      View in: PubMed
    27. Culbertson CS, Bramen J, Cohen MS, London ED, Olmstead RE, Gan JJ, Costello MR, Shulenberger S, Mandelkern MA, Brody AL. Effect of bupropion treatment on brain activation induced by cigarette-related cues in smokers. Arch Gen Psychiatry. 2011 May; 68(5):505-15. PMID: 21199957.
      View in: PubMed
    28. Brody AL, London ED, Olmstead RE, Allen-Martinez Z, Shulenberger S, Costello MR, Abrams AL, Scheibal D, Farahi J, Shoptaw S, Mandelkern MA. Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence. Psychiatry Res. 2010 Sep 30; 183(3):218-24. PMID: 20682457.
      View in: PubMed
    29. Culbertson C, Nicolas S, Zaharovits I, London ED, De La Garza R, Brody AL, Newton TF. Methamphetamine craving induced in an online virtual reality environment. Pharmacol Biochem Behav. 2010 Oct; 96(4):454-60. PMID: 20643158.
      View in: PubMed
    30. Lee B, London ED, Poldrack RA, Farahi J, Nacca A, Monterosso JR, Mumford JA, Bokarius AV, Dahlbom M, Mukherjee J, Bilder RM, Brody AL, Mandelkern MA. Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity. J Neurosci. 2009 Nov 25; 29(47):14734-40. PMID: 19940168.
      View in: PubMed
    31. Azizian A, Nestor LJ, Payer D, Monterosso JR, Brody AL, London ED. Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task. Neuropsychopharmacology. 2010 Feb; 35(3):775-82. PMID: 19907418.
      View in: PubMed
    32. Costello MR, Mandelkern MA, Shoptaw S, Shulenberger S, Baker SK, Abrams AL, Xia C, London ED, Brody AL. Effects of treatment for tobacco dependence on resting cerebral glucose metabolism. Neuropsychopharmacology. 2010 Feb; 35(3):605-12. PMID: 19865076.
      View in: PubMed
    33. Brody AL, Olmstead RE, Abrams AL, Costello MR, Khan A, Kozman D, Saxena S, Farahi J, London ED, Mandelkern MA. Effect of a history of major depressive disorder on smoking-induced dopamine release. Biol Psychiatry. 2009 Nov 01; 66(9):898-901. PMID: 19640507.
      View in: PubMed
    34. Sharma A, Brody AL. In vivo brain imaging of human exposure to nicotine and tobacco. Handb Exp Pharmacol. 2009; (192):145-71. PMID: 19184649.
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    35. Xu J, Azizian A, Monterosso J, Domier CP, Brody AL, Fong TW, London ED. Gender effects on mood and cigarette craving during early abstinence and resumption of smoking. Nicotine Tob Res. 2008 Nov; 10(11):1653-61. PMID: 18988078.
      View in: PubMed
    36. Brody AL, Mandelkern MA, Costello MR, Abrams AL, Scheibal D, Farahi J, London ED, Olmstead RE, Rose JE, Mukhin AG. Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette. Int J Neuropsychopharmacol. 2009 Apr; 12(3):305-16. PMID: 18706128.
      View in: PubMed
    37. Brody AL, Mandelkern MA, Olmstead RE, Allen-Martinez Z, Scheibal D, Abrams AL, Costello MR, Farahi J, Saxena S, Monterosso J, London ED. Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette. Neuropsychopharmacology. 2009 Jan; 34(2):282-9. PMID: 18563061.
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    38. Azizian A, Monterosso JR, Brody AL, Simon SL, London ED. Severity of nicotine dependence moderates performance on perceptual-motor tests of attention. Nicotine Tob Res. 2008 Apr; 10(4):599-606. PMID: 18418782.
      View in: PubMed
    39. Domier CP, Monterosso JR, Brody AL, Simon SL, Mendrek A, Olmstead R, Jarvik ME, Cohen MS, London ED. Effects of cigarette smoking and abstinence on Stroop task performance. Psychopharmacology (Berl). 2007 Nov; 195(1):1-9. PMID: 17634928.
      View in: PubMed
    40. Gershon Grand RB, Hwang S, Han J, George T, Brody AL. Short-term naturalistic treatment outcomes in cigarette smokers with substance abuse and/or mental illness. J Clin Psychiatry. 2007 Jun; 68(6):892-8; quiz 980-1. PMID: 17592914.
      View in: PubMed
    41. Brody AL, Mandelkern MA, Olmstead RE, Jou J, Tiongson E, Allen V, Scheibal D, London ED, Monterosso JR, Tiffany ST, Korb A, Gan JJ, Cohen MS. Neural substrates of resisting craving during cigarette cue exposure. Biol Psychiatry. 2007 Sep 15; 62(6):642-51. PMID: 17217932.
      View in: PubMed
    42. Xu J, Mendrek A, Cohen MS, Monterosso J, Simon S, Jarvik M, Olmstead R, Brody AL, Ernst M, London ED. Effect of cigarette smoking on prefrontal cortical function in nondeprived smokers performing the Stroop Task. Neuropsychopharmacology. 2007 Jun; 32(6):1421-8. PMID: 17164821.
      View in: PubMed
    43. Xu J, Mendrek A, Cohen MS, Monterosso J, Simon S, Brody AL, Jarvik M, Rodriguez P, Ernst M, London ED. Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back task: a preliminary study. Psychiatry Res. 2006 Dec 01; 148(2-3):103-9. PMID: 17088048.
      View in: PubMed
    44. Brody AL, Mandelkern MA, London ED, Olmstead RE, Farahi J, Scheibal D, Jou J, Allen V, Tiongson E, Chefer SI, Koren AO, Mukhin AG. Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. Arch Gen Psychiatry. 2006 Aug; 63(8):907-15. PMID: 16894067.
      View in: PubMed
    45. Brody AL, Mandelkern MA, Olmstead RE, Scheibal D, Hahn E, Shiraga S, Zamora-Paja E, Farahi J, Saxena S, London ED, McCracken JT. Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens. Arch Gen Psychiatry. 2006 Jul; 63(7):808-16. PMID: 16818870.
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    46. Saxena S, Brody AL, Maidment KM, Baxter LR. Paroxetine treatment of compulsive hoarding. J Psychiatr Res. 2007 Sep; 41(6):481-7. PMID: 16790250.
      View in: PubMed
    47. Obrzut SL, Koren AO, Mandelkern MA, Brody AL, Hoh CK, London ED. Whole-body radiation dosimetry of 2-[18F]Fluoro-A-85380 in human PET imaging studies. Nucl Med Biol. 2005 Nov; 32(8):869-74. PMID: 16253812.
      View in: PubMed
    48. London ED, Berman SM, Voytek B, Simon SL, Mandelkern MA, Monterosso J, Thompson PM, Brody AL, Geaga JA, Hong MS, Hayashi KM, Rawson RA, Ling W. Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers. Biol Psychiatry. 2005 Nov 15; 58(10):770-8. PMID: 16095568.
      View in: PubMed
    49. Voytek B, Berman SM, Hassid BD, Simon SL, Mandelkern MA, Brody AL, Monterosso J, Ling W, London ED. Differences in regional brain metabolism associated with marijuana abuse in methamphetamine abusers. Synapse. 2005 Aug; 57(2):113-5. PMID: 15906384.
      View in: PubMed
    50. Xu J, Mendrek A, Cohen MS, Monterosso J, Rodriguez P, Simon SL, Brody A, Jarvik M, Domier CP, Olmstead R, Ernst M, London ED. Brain activity in cigarette smokers performing a working memory task: effect of smoking abstinence. Biol Psychiatry. 2005 Jul 15; 58(2):143-50. PMID: 16038685.
      View in: PubMed
    51. Mendrek A, Monterosso J, Simon SL, Jarvik M, Brody A, Olmstead R, Domier CP, Cohen MS, Ernst M, London ED. Working memory in cigarette smokers: comparison to non-smokers and effects of abstinence. Addict Behav. 2006 May; 31(5):833-44. PMID: 16009504.
      View in: PubMed
    52. Brody AL. Functional brain imaging of tobacco use and dependence. J Psychiatr Res. 2006 Aug; 40(5):404-18. PMID: 15979645.
      View in: PubMed
    53. Baicy K, Bearden CE, Monterosso J, Brody AL, Isaacson AJ, London ED. Common substrates of dysphoria in stimulant drug abuse and primary depression: therapeutic targets. Int Rev Neurobiol. 2005; 65:117-45. PMID: 16140055.
      View in: PubMed
    54. Brody AL, Olmstead RE, London ED, Farahi J, Meyer JH, Grossman P, Lee GS, Huang J, Hahn EL, Mandelkern MA. Smoking-induced ventral striatum dopamine release. Am J Psychiatry. 2004 Jul; 161(7):1211-8. PMID: 15229053.
      View in: PubMed
    55. Brody AL, Mandelkern MA, Lee G, Smith E, Sadeghi M, Saxena S, Jarvik ME, London ED. Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study. Psychiatry Res. 2004 Apr 30; 130(3):269-81. PMID: 15135160.
      View in: PubMed
    56. Brody AL, Mandelkern MA, Jarvik ME, Lee GS, Smith EC, Huang JC, Bota RG, Bartzokis G, London ED. Differences between smokers and nonsmokers in regional gray matter volumes and densities. Biol Psychiatry. 2004 Jan 01; 55(1):77-84. PMID: 14706428.
      View in: PubMed
    57. Saxena S, Brody AL, Ho ML, Zohrabi N, Maidment KM, Baxter LR. Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression. Am J Psychiatry. 2003 Mar; 160(3):522-32. PMID: 12611834.
      View in: PubMed
    58. Brody AL, Mandelkern MA, London ED, Childress AR, Lee GS, Bota RG, Ho ML, Saxena S, Baxter LR, Madsen D, Jarvik ME. Brain metabolic changes during cigarette craving. Arch Gen Psychiatry. 2002 Dec; 59(12):1162-72. PMID: 12470133.
      View in: PubMed
    59. Saxena S, Brody AL, Ho ML, Alborzian S, Maidment KM, Zohrabi N, Ho MK, Huang SC, Wu HM, Baxter LR. Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression. Arch Gen Psychiatry. 2002 Mar; 59(3):250-61. PMID: 11879163.
      View in: PubMed
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