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Arthur Brody

Title(s)Professor In Residence, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    UCLAResidency1994Department of Psychiatry
    Tufts UniversityM.D.1990School of Medicine
    Vassar CollegeB.A.1986
    Collapse Awards and Honors
    UCLA Department of Psychiatry2009  - 2012Richard Metzner Endowed Chair
    Neuropsychopharmacology2013  - 2015Reviewer Appreciation Award
    VA Clinical Science Research and Development Services  - 2009Certificate of Appreciation
    American Psychiatric Association  - 2008Distinguished Fellow
    Department of Veterans Affairs2003  - 2003Goal Sharing Award
    National Alliance for Research on Schizophrenia and Depression1995  - 1997Daniel X. Freeman Award
    Vassar College1982  - 1986Cum Laude

    Collapse Overview 
    Collapse Overview
    Research and Clinical Interests: Tobacco Use Disorder; Positron Emission Tomography; Treatment of Cigarette Smoking

    Collapse Research 
    Collapse Research Activities and Funding
    Cross-species studies of smoking effects on cognition and neuroinflammation in HIV
    NIH R01DA044909Aug 1, 2017 - Jul 31, 2022
    Role: Co-Principal Investigator
    Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    NIH I01CX000412Jan 1, 2013 - Dec 31, 2017
    Role: Principal Investigator
    Brain Nicotine Receptor Density & Response to Nicotine Patch
    NIH R01DA020872Sep 30, 2005 - Nov 30, 2013
    Role: Principal Investigator
    Treatments for Nicotine Dependence: Brain Mechanisms
    NIH R01DA015059Sep 30, 2002 - Aug 31, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. No significant elevation of translocator protein binding in the brains of recently abstinent methamphetamine users. Drug Alcohol Depend. 2020 Jun 11; 213:108104. London ED, Okita K, Kinney KR, Dean AC, McClintick MN, Rizor EJ, Johnson MC, Mahmoudie T, Brody AL, Nurmi EL, Seaman LC, Farahi J, Ginder N, Mandelkern MA. PMID: 32570138.
      View in: PubMed   Mentions:    Fields:    
    2. Effects of Citalopram on Cue-Induced Alcohol Craving and Thalamic D2/3 Dopamine Receptor Availability. Int J Neuropsychopharmacol. 2019 04 01; 22(4):286-291. Zorick T, Okita K, Mandelkern MA, London ED, Brody AL. PMID: 30753467.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Effect of overnight smoking abstinence on a marker for microglial activation: a [11C]DAA1106 positron emission tomography study. Psychopharmacology (Berl). 2018 Dec; 235(12):3525-3534. Brody AL, Gehlbach D, Garcia LY, Enoki R, Hoh C, Vera D, Kotta KK, London ED, Okita K, Nurmi EL, Seaman LC, Mandelkern MA. PMID: 30343364.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    4. Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [11C]DAA1106 Positron Emission Tomography Study. Neuropsychopharmacology. 2018 03; 43(4):925. Brody AL, Hubert R, Enoki R, Garcia LY, Mamoun MS, Okita K, London ED, Nurmi EL, Seaman LC, Mandelkern MA. PMID: 29422498.
      View in: PubMed   Mentions: 1     Fields:    
    5. Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [11C]DAA1106 Positron Emission Tomography Study. Neuropsychopharmacology. 2017 Jul; 42(8):1630-1639. PMID: 28262740.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    6. Cholinergic Receptor Binding in Alzheimer Disease and Healthy Aging: Assessment In Vivo with Positron Emission Tomography Imaging. Am J Geriatr Psychiatry. 2017 Apr; 25(4):342-353. PMID: 28162919.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    7. Combination Extended Smoking Cessation Treatment Plus Home Visits for Smokers With Schizophrenia: A Randomized Controlled Trial. Nicotine Tob Res. 2017 01; 19(1):68-76. PMID: 27613888.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Nicotinic acetylcholine receptor availability in cigarette smokers: effect of heavy caffeine or marijuana use. Psychopharmacology (Berl). 2016 Sep; 233(17):3249-57. PMID: 27370018.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism. J Nucl Med. 2015 Nov; 56(11):1724-9. PMID: 26272810.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    10. Prediction of smoking cessation with treatment: the emerging contribution of brain imaging research. Neuropsychopharmacology. 2015 May; 40(6):1309-10. PMID: 25868069.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Biomarkers of Response to Smoking Cessation Pharmacotherapies: Progress to Date. CNS Drugs. 2015 May; 29(5):359-69. PMID: 25895022.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    12. A naturalistic study of the association between antidepressant treatment and outcome of smoking cessation treatment. J Clin Psychiatry. 2014 Dec; 75(12):e1433-8. PMID: 25551240.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Radiation dosimetry and biodistribution of the translocator protein radiotracer [(11)C]DAA1106 determined with PET/CT in healthy human volunteers. Nucl Med Biol. 2014 Nov-Dec; 41(10):871-5. PMID: 25156039.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial. JAMA Psychiatry. 2014 Jul 01; 71(7):797-805. PMID: 24850280.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    15. Varenicline, naltrexone, and their combination for heavy-drinking smokers: preliminary neuroimaging findings. Am J Drug Alcohol Abuse. 2015 Jan; 41(1):35-44. PMID: 24949564.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    16. Varenicline, low dose naltrexone, and their combination for heavy-drinking smokers: human laboratory findings. Psychopharmacology (Berl). 2014 Oct; 231(19):3843-53. PMID: 24733235.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    17. A positive relationship between harm avoidance and brain nicotinic acetylcholine receptor availability. Psychiatry Res. 2013 Dec 30; 214(3):415-21. PMID: 24148908.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. Elevation of dopamine induced by cigarette smoking: novel insights from a [11C]-+-PHNO PET study in humans. Neuropsychopharmacology. 2014 Jan; 39(2):415-24. PMID: 23954846.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    19. Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans. Neuropharmacology. 2014 Sep; 84:111-22. PMID: 23474015.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    20. Diminished neurokinin-1 receptor availability in patients with two forms of chronic visceral pain. Pain. 2013 Jul; 154(7):987-96. PMID: 23582152.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    21. Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density. Neuropsychopharmacology. 2013 Jul; 38(8):1548-56. PMID: 23429692.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    22. Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers. Int J Neuropsychopharmacol. 2013 Jun; 16(5):957-66. PMID: 23171716.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    23. A single administration of low-dose varenicline saturates a4ß2* nicotinic acetylcholine receptors in the human brain. Neuropsychopharmacology. 2012 Jun; 37(7):1738-48. PMID: 22395733.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    24. VIRTUAL REALITY CUE EXPOSURE THERAPY FOR THE TREATMENT OF TOBACCO DEPENDENCE. J Cyber Ther Rehabil. 2012; 5(1):57-64. PMID: 25342999.
      View in: PubMed   Mentions:
    25. Manipulation of cigarette craving with transcranial magnetic stimulation. Biol Psychiatry. 2011 Oct 15; 70(8):702-703. PMID: 21967985.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Large Sample Group Independent Component Analysis of Functional Magnetic Resonance Imaging Using Anatomical Atlas-Based Reduction and Bootstrapped Clustering. Int J Imaging Syst Technol. 2011 Jun; 21(2):223-231. PMID: 22049263.
      View in: PubMed   Mentions:
    27. Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain. Arch Gen Psychiatry. 2011 Sep; 68(9):953-60. PMID: 21536968.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansPHPublic Health
    28. Quantitative Molecular Imaging of Neuronal Nicotinic Acetylcholine Receptors in the Human Brain with A-85380 Radiotracers. Curr Med Imaging Rev. 2011 May 01; 7(2):107-112. PMID: 22773924.
      View in: PubMed   Mentions:
    29. Effect of bupropion treatment on brain activation induced by cigarette-related cues in smokers. Arch Gen Psychiatry. 2011 May; 68(5):505-15. Culbertson CS, Bramen J, Cohen MS, London ED, Olmstead RE, Gan JJ, Costello MR, Shulenberger S, Mandelkern MA, Brody AL. PMID: 21199957.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    30. Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence. Psychiatry Res. 2010 Sep 30; 183(3):218-24. Brody AL, London ED, Olmstead RE, Allen-Martinez Z, Shulenberger S, Costello MR, Abrams AL, Scheibal D, Farahi J, Shoptaw S, Mandelkern MA. PMID: 20682457.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCellsCTClinical Trials
    31. Methamphetamine craving induced in an online virtual reality environment. Pharmacol Biochem Behav. 2010 Oct; 96(4):454-60. Culbertson C, Nicolas S, Zaharovits I, London ED, De La Garza R, Brody AL, Newton TF. PMID: 20643158.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    32. Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity. J Neurosci. 2009 Nov 25; 29(47):14734-40. Lee B, London ED, Poldrack RA, Farahi J, Nacca A, Monterosso JR, Mumford JA, Bokarius AV, Dahlbom M, Mukherjee J, Bilder RM, Brody AL, Mandelkern MA. PMID: 19940168.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansCells
    33. Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task. Neuropsychopharmacology. 2010 Feb; 35(3):775-82. Azizian A, Nestor LJ, Payer D, Monterosso JR, Brody AL, London ED. PMID: 19907418.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    34. Effects of treatment for tobacco dependence on resting cerebral glucose metabolism. Neuropsychopharmacology. 2010 Feb; 35(3):605-12. Costello MR, Mandelkern MA, Shoptaw S, Shulenberger S, Baker SK, Abrams AL, Xia C, London ED, Brody AL. PMID: 19865076.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    35. Effect of a history of major depressive disorder on smoking-induced dopamine release. Biol Psychiatry. 2009 Nov 01; 66(9):898-901. Brody AL, Olmstead RE, Abrams AL, Costello MR, Khan A, Kozman D, Saxena S, Farahi J, London ED, Mandelkern MA. PMID: 19640507.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    36. In vivo brain imaging of human exposure to nicotine and tobacco. Handb Exp Pharmacol. 2009; (192):145-71. Sharma A, Brody AL. PMID: 19184649.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    37. Gender effects on mood and cigarette craving during early abstinence and resumption of smoking. Nicotine Tob Res. 2008 Nov; 10(11):1653-61. Xu J, Azizian A, Monterosso J, Domier CP, Brody AL, Fong TW, London ED. PMID: 18988078.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    38. Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette. Int J Neuropsychopharmacol. 2009 Apr; 12(3):305-16. Brody AL, Mandelkern MA, Costello MR, Abrams AL, Scheibal D, Farahi J, London ED, Olmstead RE, Rose JE, Mukhin AG. PMID: 18706128.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCTClinical Trials
    39. Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette. Neuropsychopharmacology. 2009 Jan; 34(2):282-9. Brody AL, Mandelkern MA, Olmstead RE, Allen-Martinez Z, Scheibal D, Abrams AL, Costello MR, Farahi J, Saxena S, Monterosso J, London ED. PMID: 18563061.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    40. Severity of nicotine dependence moderates performance on perceptual-motor tests of attention. Nicotine Tob Res. 2008 Apr; 10(4):599-606. Azizian A, Monterosso JR, Brody AL, Simon SL, London ED. PMID: 18418782.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. Effects of cigarette smoking and abstinence on Stroop task performance. Psychopharmacology (Berl). 2007 Nov; 195(1):1-9. Domier CP, Monterosso JR, Brody AL, Simon SL, Mendrek A, Olmstead R, Jarvik ME, Cohen MS, London ED. PMID: 17634928.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    42. Short-term naturalistic treatment outcomes in cigarette smokers with substance abuse and/or mental illness. J Clin Psychiatry. 2007 Jun; 68(6):892-8; quiz 980-1. Gershon Grand RB, Hwang S, Han J, George T, Brody AL. PMID: 17592914.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    43. Neural substrates of resisting craving during cigarette cue exposure. Biol Psychiatry. 2007 Sep 15; 62(6):642-51. Brody AL, Mandelkern MA, Olmstead RE, Jou J, Tiongson E, Allen V, Scheibal D, London ED, Monterosso JR, Tiffany ST, Korb A, Gan JJ, Cohen MS. PMID: 17217932.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimals
    44. Effect of cigarette smoking on prefrontal cortical function in nondeprived smokers performing the Stroop Task. Neuropsychopharmacology. 2007 Jun; 32(6):1421-8. Xu J, Mendrek A, Cohen MS, Monterosso J, Simon S, Jarvik M, Olmstead R, Brody AL, Ernst M, London ED. PMID: 17164821.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    45. Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back task: a preliminary study. Psychiatry Res. 2006 Dec 01; 148(2-3):103-9. Xu J, Mendrek A, Cohen MS, Monterosso J, Simon S, Brody AL, Jarvik M, Rodriguez P, Ernst M, London ED. PMID: 17088048.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    46. Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. Arch Gen Psychiatry. 2006 Aug; 63(8):907-15. Brody AL, Mandelkern MA, London ED, Olmstead RE, Farahi J, Scheibal D, Jou J, Allen V, Tiongson E, Chefer SI, Koren AO, Mukhin AG. PMID: 16894067.
      View in: PubMed   Mentions: 157     Fields:    Translation:Humans
    47. Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens. Arch Gen Psychiatry. 2006 Jul; 63(7):808-16. Brody AL, Mandelkern MA, Olmstead RE, Scheibal D, Hahn E, Shiraga S, Zamora-Paja E, Farahi J, Saxena S, London ED, McCracken JT. PMID: 16818870.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    48. Paroxetine treatment of compulsive hoarding. J Psychiatr Res. 2007 Sep; 41(6):481-7. Saxena S, Brody AL, Maidment KM, Baxter LR. PMID: 16790250.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCTClinical Trials
    49. Whole-body radiation dosimetry of 2-[18F]Fluoro-A-85380 in human PET imaging studies. Nucl Med Biol. 2005 Nov; 32(8):869-74. Obrzut SL, Koren AO, Mandelkern MA, Brody AL, Hoh CK, London ED. PMID: 16253812.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    50. Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers. Biol Psychiatry. 2005 Nov 15; 58(10):770-8. London ED, Berman SM, Voytek B, Simon SL, Mandelkern MA, Monterosso J, Thompson PM, Brody AL, Geaga JA, Hong MS, Hayashi KM, Rawson RA, Ling W. PMID: 16095568.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    51. Differences in regional brain metabolism associated with marijuana abuse in methamphetamine abusers. Synapse. 2005 Aug; 57(2):113-5. Voytek B, Berman SM, Hassid BD, Simon SL, Mandelkern MA, Brody AL, Monterosso J, Ling W, London ED. PMID: 15906384.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    52. Brain activity in cigarette smokers performing a working memory task: effect of smoking abstinence. Biol Psychiatry. 2005 Jul 15; 58(2):143-50. Xu J, Mendrek A, Cohen MS, Monterosso J, Rodriguez P, Simon SL, Brody A, Jarvik M, Domier CP, Olmstead R, Ernst M, London ED. PMID: 16038685.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCTClinical Trials
    53. Working memory in cigarette smokers: comparison to non-smokers and effects of abstinence. Addict Behav. 2006 May; 31(5):833-44. Mendrek A, Monterosso J, Simon SL, Jarvik M, Brody A, Olmstead R, Domier CP, Cohen MS, Ernst M, London ED. PMID: 16009504.
      View in: PubMed   Mentions: 76     Fields:    Translation:Humans
    54. Functional brain imaging of tobacco use and dependence. J Psychiatr Res. 2006 Aug; 40(5):404-18. Brody AL. PMID: 15979645.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimals
    55. Common substrates of dysphoria in stimulant drug abuse and primary depression: therapeutic targets. Int Rev Neurobiol. 2005; 65:117-45. Baicy K, Bearden CE, Monterosso J, Brody AL, Isaacson AJ, London ED. PMID: 16140055.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    56. Smoking-induced ventral striatum dopamine release. Am J Psychiatry. 2004 Jul; 161(7):1211-8. Brody AL, Olmstead RE, London ED, Farahi J, Meyer JH, Grossman P, Lee GS, Huang J, Hahn EL, Mandelkern MA. PMID: 15229053.
      View in: PubMed   Mentions: 107     Fields:    Translation:Humans
    57. Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study. Psychiatry Res. 2004 Apr 30; 130(3):269-81. Brody AL, Mandelkern MA, Lee G, Smith E, Sadeghi M, Saxena S, Jarvik ME, London ED. PMID: 15135160.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    58. Differences between smokers and nonsmokers in regional gray matter volumes and densities. Biol Psychiatry. 2004 Jan 01; 55(1):77-84. Brody AL, Mandelkern MA, Jarvik ME, Lee GS, Smith EC, Huang JC, Bota RG, Bartzokis G, London ED. PMID: 14706428.
      View in: PubMed   Mentions: 144     Fields:    Translation:Humans
    59. Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression. Am J Psychiatry. 2003 Mar; 160(3):522-32. Saxena S, Brody AL, Ho ML, Zohrabi N, Maidment KM, Baxter LR. PMID: 12611834.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    60. Brain metabolic changes during cigarette craving. Arch Gen Psychiatry. 2002 Dec; 59(12):1162-72. Brody AL, Mandelkern MA, London ED, Childress AR, Lee GS, Bota RG, Ho ML, Saxena S, Baxter LR, Madsen D, Jarvik ME. PMID: 12470133.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansCTClinical Trials
    61. Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression. Arch Gen Psychiatry. 2002 Mar; 59(3):250-61. Saxena S, Brody AL, Ho ML, Alborzian S, Maidment KM, Zohrabi N, Ho MK, Huang SC, Wu HM, Baxter LR. PMID: 11879163.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
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