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    Yury Miller

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0682
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      AIBP and regulation of neuropathic pain
      NIH/NINDS R01NS102432Aug 15, 2017 - May 31, 2022
      Role: Principal Investigator
      AIBP therapy
      NIH/NHLBI R35HL135737Feb 1, 2017 - Jan 31, 2024
      Role: Principal Investigator
      AIBP and Endothelial Function
      NIH/NHLBI R01HL124174Apr 1, 2015 - Mar 31, 2019
      Role: Principal Investigator
      Zebrafish models of vascular inflammation and atherosclerosis
      NIH/NHLBI R01HL093767Jul 1, 2008 - Jun 30, 2015
      Role: Principal Investigator
      Role of Immune Mechanisms in Athersclerosis and Inflammation
      NIH/NHLBI P01HL088093Apr 1, 2007 - Apr 30, 2019
      Role: Co-Investigator
      Early Forms of Oxidized LDL, TLRs and Atherosclerosis
      NIH/NHLBI R01HL081862Apr 1, 2006 - Mar 31, 2012
      Role: Principal Investigator
      Immune Cells in Atherosclerosis and Vascular Disease
      NIH P01HL055798Sep 30, 1995 - Jul 31, 2017
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Mao R, Meng S, Gu Q, Araujo-Gutierrez R, Kumar S, Yan Q, Almazan F, Youker KA, Fu Y, Pownall HJ, Cooke JP, Miller Y, Fang L. AIBP Limits Angiogenesis Through ?-Secretase-Mediated Upregulation of Notch Signaling. Circ Res. 2017 May 26; 120(11):1727-1739. PMID: 28325782.
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      2. Liu C, Gaudet D, Miller Y. Deficient Cholesterol Esterification in Plasma of apoc2 Knockout Zebrafish and Familial Chylomicronemia Patients. PLoS One. 2017; 12(1):e0169939. PMID: 28107429.
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      3. Miller Y, Shyy JY. Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation. Trends Endocrinol Metab. 2017 Feb; 28(2):143-152. PMID: 27931771.
        View in: PubMed
      4. Sviridov D, Miller Y. Ins and outs of the ATP-binding cassette transporter A1. Curr Opin Lipidol. 2016 Aug; 27(4):429-30. PMID: 27383285.
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      5. Choi SH, Sviridov D, Miller Y. Oxidized cholesteryl esters and inflammation. Biochim Biophys Acta. 2017 04; 1862(4):393-397. PMID: 27368140.
        View in: PubMed
      6. Yang X, Lee SR, Choi YS, Alexander VJ, Digenio A, Yang Q, Miller Y, Witztum JL, Tsimikas S. Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results. J Lipid Res. 2016 Apr; 57(4):706-13. PMID: 26848137; PMCID: PMC4808774 [Available on 04/01/17].
      7. Choi SH, Kim J, Gonen A, Viriyakosol S, Miller Y. MD-2 binds cholesterol. Biochem Biophys Res Commun. 2016 Feb 19; 470(4):877-80. PMID: 26806306; PMCID: PMC4915372 [Available on 02/19/17].
      8. Liu C, Gates KP, Fang L, Amar MJ, Schneider DA, Geng H, Huang W, Kim J, Pattison J, Zhang J, Witztum JL, Remaley AT, Dong PD, Miller Y. Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia. Dis Model Mech. 2015 Aug 01; 8(8):989-98. PMID: 26044956; PMCID: PMC4527288.
      9. Yang H, Fang L, Zhan R, Hegarty JM, Ren J, Hsiai TK, Gleeson JG, Miller Y, Trejo J, Chi NC. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Dev Biol. 2015 Aug 15; 404(2):49-60. PMID: 26004360; PMCID: PMC4515213.
      10. Choi SH, Gonen A, Diehl CJ, Kim J, Almazan F, Witztum JL, Miller Y. SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL. Autophagy. 2015; 11(5):785-95. PMID: 25946330; PMCID: PMC4509444.
      11. Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller Y, Huang PH, Shyy JY. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. Circulation. 2015 Mar 03; 131(9):805-14. PMID: 25550450; PMCID: PMC4351177.
      12. Lazic M, Inzaugarat ME, Povero D, Zhao IC, Chen M, Nalbandian M, Miller Y, Cherñavsky AC, Feldstein AE, Sears DD. Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis. PLoS One. 2014; 9(9):e107658. PMID: 25251155; PMCID: PMC4175074.
      13. Ai D, Jiang H, Westerterp M, Murphy AJ, Wang M, Ganda A, Abramowicz S, Welch C, Almazan F, Zhu Y, Miller Y, Tall AR. Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis. Circ Res. 2014 May 09; 114(10):1576-84. PMID: 24687132; PMCID: PMC4058053.
      14. Ravandi A, Leibundgut G, Hung MY, Patel M, Hutchins PM, Murphy RC, Prasad A, Mahmud E, Miller Y, Dennis EA, Witztum JL, Tsimikas S. Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. J Am Coll Cardiol. 2014 May 20; 63(19):1961-71. PMID: 24613321; PMCID: PMC4629781.
      15. Choi SH, Yin H, Ravandi A, Armando A, Dumlao D, Kim J, Almazan F, Taylor AM, McNamara CA, Tsimikas S, Dennis EA, Witztum JL, Miller Y. Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages. PLoS One. 2013; 8(12):e83145. PMID: 24376657; PMCID: PMC3871536.
      16. Fang L, Liu C, Miller Y. Zebrafish models of dyslipidemia: relevance to atherosclerosis and angiogenesis. Transl Res. 2014 Feb; 163(2):99-108. PMID: 24095954; PMCID: PMC3946603.
      17. Miller Y, Tsimikas S. Oxidation-specific epitopes as targets for biotheranostic applications in humans: biomarkers, molecular imaging and therapeutics. Curr Opin Lipidol. 2013 Oct; 24(5):426-37. PMID: 23995232; PMCID: PMC4085330.
      18. Fang L, Miller Y. Targeted cholesterol efflux. Cell Cycle. 2013 Nov 01; 12(21):3345-6. PMID: 24036659; PMCID: PMC3895418.
      19. Lee J, Moghadam ME, Kung E, Cao H, Beebe T, Miller Y, Roman BL, Lien CL, Chi NC, Marsden AL, Hsiai TK. Moving domain computational fluid dynamics to interface with an embryonic model of cardiac morphogenesis. PLoS One. 2013; 8(8):e72924. PMID: 24009714; PMCID: PMC3751826.
      20. Fang L, Choi SH, Baek JS, Liu C, Almazan F, Ulrich F, Wiesner P, Taleb A, Deer E, Pattison J, Torres-Vázquez J, Li AC, Miller Y. Control of angiogenesis by AIBP-mediated cholesterol efflux. Nature. 2013 Jun 06; 498(7452):118-22. PMID: 23719382; PMCID: PMC3760669.
      21. Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum JL, Handel TM, Tsimikas S, Miller Y. MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma. J Lipid Res. 2013 Jul; 54(7):1877-83. PMID: 23667177; PMCID: PMC3679389.
      22. Miller Y, Choi SH, Wiesner P, Bae YS. The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL. Br J Pharmacol. 2012 Nov; 167(5):990-9. PMID: 22776094; PMCID: PMC3492981.
      23. Koltsova EK, Garcia Z, Chodaczek G, Landau M, McArdle S, Scott SR, von Vietinghoff S, Galkina E, Miller Y, Acton ST, Ley K. Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis. J Clin Invest. 2012 Sep; 122(9):3114-26. PMID: 22886300; PMCID: PMC3428082.
      24. Fang L, Miller Y. Emerging applications for zebrafish as a model organism to study oxidative mechanisms and their roles in inflammation and vascular accumulation of oxidized lipids. Free Radic Biol Med. 2012 Oct 01; 53(7):1411-20. PMID: 22906686; PMCID: PMC3448821.
      25. Baek JS, Fang L, Li AC, Miller Y. Ezetimibe and simvastatin reduce cholesterol levels in zebrafish larvae fed a high-cholesterol diet. Cholesterol. 2012; 2012:564705. PMID: 22693663; PMCID: PMC3369394.
      26. Barish GD, Yu RT, Karunasiri MS, Becerra D, Kim J, Tseng TW, Tai LJ, Leblanc M, Diehl C, Cerchietti L, Miller Y, Witztum JL, Melnick AM, Dent AL, Tangirala RK, Evans RM. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab. 2012 Apr 04; 15(4):554-62. PMID: 22465074; PMCID: PMC3367511.
      27. Choi SH, Wiesner P, Almazan F, Kim J, Miller Y. Spleen tyrosine kinase regulates AP-1 dependent transcriptional response to minimally oxidized LDL. PLoS One. 2012; 7(2):e32378. PMID: 22384232; PMCID: PMC3284564.
      28. Chung JH, Jeon HJ, Hong SY, Lee DL, Lee KH, Kim SH, Han YS, Manabe I, Miller Y, Lee SH. Palmitate promotes the paracrine effects of macrophages on vascular smooth muscle cells: the role of bone morphogenetic proteins. PLoS One. 2012; 7(2):e29100. PMID: 22363399; PMCID: PMC3283596.
      29. Briley-Saebo KC, Nguyen TH, Saeboe AM, Cho YS, Ryu SK, Volkova ER, Volkava E, Dickson S, Leibundgut G, Wiesner P, Weisner P, Green S, Casanada F, Miller Y, Shaw W, Witztum JL, Fayad ZA, Tsimikas S. In vivo detection of oxidation-specific epitopes in atherosclerotic lesions using biocompatible manganese molecular magnetic imaging probes. J Am Coll Cardiol. 2012 Feb 07; 59(6):616-26. PMID: 22300697; PMCID: PMC3333483.
      30. Fang L, Green SR, Baek JS, Lee SH, Ellett F, Deer E, Lieschke GJ, Witztum JL, Tsimikas S, Miller Y. In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish. J Clin Invest. 2011 Dec; 121(12):4861-9. PMID: 22105168; PMCID: PMC3225997.
      31. Ley K, Miller Y, Hedrick CC. Monocyte and macrophage dynamics during atherogenesis. Arterioscler Thromb Vasc Biol. 2011 Jul; 31(7):1506-16. PMID: 21677293; PMCID: PMC3133596.
      32. Miller Y, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res. 2011 Jan 21; 108(2):235-48. PMID: 21252151; PMCID: PMC3075542.
      33. Tsimikas S, Miller Y. Oxidative modification of lipoproteins: mechanisms, role in inflammation and potential clinical applications in cardiovascular disease. Curr Pharm Des. 2011; 17(1):27-37. PMID: 21226665.
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      34. Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum JL, Tsimikas S, Miller Y. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. J Biol Chem. 2010 Oct 15; 285(42):32343-51. PMID: 20710028; PMCID: PMC2952235.
      35. Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller Y. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010 Jul 09; 107(1):56-65. PMID: 20489162; PMCID: PMC2904601.
      36. Miller Y, Choi SH, Fang L, Tsimikas S. Lipoprotein modification and macrophage uptake: role of pathologic cholesterol transport in atherogenesis. Subcell Biochem. 2010; 51:229-51. PMID: 20213546.
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      37. Miller Y, Choi SH, Fang L, Harkewicz R. Toll-like receptor-4 and lipoprotein accumulation in macrophages. Trends Cardiovasc Med. 2009 Oct; 19(7):227-32. PMID: 20382346; PMCID: PMC2854673.
      38. Sears DD, Miles PD, Chapman J, Ofrecio JM, Almazan F, Thapar D, Miller Y. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS One. 2009 Sep 29; 4(9):e7250. PMID: 19787041; PMCID: PMC2746280.
      39. Choi SH, Harkewicz R, Lee JH, Boullier A, Almazan F, Li AC, Witztum JL, Bae YS, Miller Y. Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ Res. 2009 Jun 19; 104(12):1355-63. PMID: 19461045; PMCID: PMC2741301.
      40. Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller Y, Hörkkö S, Corr M, Witztum JL, Binder CJ. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest. 2009 May; 119(5):1335-49. PMID: 19363291; PMCID: PMC2673862.
      41. Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL, Klemke RL, Miller Y. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res. 2009 Apr 24; 104(8):952-60. PMID: 19265037; PMCID: PMC2834250.
      42. Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller Y. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ Res. 2009 Jan 30; 104(2):210-8, 21p following 218. PMID: 19096031; PMCID: PMC2720065.
      43. Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum JL, Miller Y. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein. J Biol Chem. 2008 Apr 18; 283(16):10241-51. PMID: 18263582; PMCID: PMC2447632.
      44. Cho HJ, Shashkin P, Gleissner CA, Dunson D, Jain N, Lee JK, Miller Y, Ley K. Induction of dendritic cell-like phenotype in macrophages during foam cell formation. Physiol Genomics. 2007 Apr 24; 29(2):149-60. PMID: 17244792.
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      45. Tuominen A, Miller Y, Hansen LF, Kesäniemi YA, Witztum JL, Hörkkö S. A natural antibody to oxidized cardiolipin binds to oxidized low-density lipoprotein, apoptotic cells, and atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2006 Sep; 26(9):2096-102. PMID: 16794225.
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      46. Shashkin PN, Jain N, Miller Y, Rissing BA, Huo Y, Keller SR, Vandenhoff GE, Nadler JL, McIntyre TM. Insulin and glucose play a role in foam cell formation and function. Cardiovasc Diabetol. 2006 Jun 20; 5:13. PMID: 16787541; PMCID: PMC1550220.
      47. Green SR, Han KH, Chen Y, Almazan F, Charo IF, Miller Y, Quehenberger O. The CC chemokine MCP-1 stimulates surface expression of CX3CR1 and enhances the adhesion of monocytes to fractalkine/CX3CL1 via p38 MAPK. J Immunol. 2006 Jun 15; 176(12):7412-20. PMID: 16751386.
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      48. Boullier A, Li Y, Quehenberger O, Palinski W, Tabas I, Witztum JL, Miller Y. Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages. Arterioscler Thromb Vasc Biol. 2006 May; 26(5):1169-76. PMID: 16484596.
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      49. Miller Y. Toll-like receptors and atherosclerosis: oxidized LDL as an endogenous Toll-like receptor ligand. Future Cardiol. 2005 Nov; 1(6):785-92. PMID: 19804052.
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      50. Zeng X, Chen J, Miller Y, Javaherian K, Moulton KS. Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis. J Lipid Res. 2005 Sep; 46(9):1849-59. PMID: 15995169.
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      51. Binder CJ, Shaw PX, Chang MK, Boullier A, Hartvigsen K, Hörkkö S, Miller Y, Woelkers DA, Corr M, Witztum JL. The role of natural antibodies in atherogenesis. J Lipid Res. 2005 Jul; 46(7):1353-63. PMID: 15897601.
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      52. Miller Y, Viriyakosol S, Worrall DS, Boullier A, Butler S, Witztum JL. Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler Thromb Vasc Biol. 2005 Jun; 25(6):1213-9. PMID: 15718493.
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      53. Chang MK, Binder CJ, Miller Y, Subbanagounder G, Silverman GJ, Berliner JA, Witztum JL. Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. J Exp Med. 2004 Dec 06; 200(11):1359-70. PMID: 15583011; PMCID: PMC2211955.
      54. Miller Y, Chang MK, Binder CJ, Shaw PX, Witztum JL. Oxidized low density lipoprotein and innate immune receptors. Curr Opin Lipidol. 2003 Oct; 14(5):437-45. PMID: 14501582.
        View in: PubMed
      55. Miller Y, Worrall DS, Funk CD, Feramisco JR, Witztum JL. Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: role of 12/15-lipoxygenase and phosphoinositide 3-kinase. Mol Biol Cell. 2003 Oct; 14(10):4196-206. PMID: 14517329; PMCID: PMC207011.
      56. Miller Y, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem. 2003 Jan 17; 278(3):1561-8. PMID: 12424240.
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      57. Binder CJ, Chang MK, Shaw PX, Miller Y, Hartvigsen K, Dewan A, Witztum JL. Innate and acquired immunity in atherogenesis. Nat Med. 2002 Nov; 8(11):1218-26. PMID: 12411948.
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      58. Miller Y, Chang MK, Funk CD, Feramisco JR, Witztum JL. 12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells. J Biol Chem. 2001 Jun 01; 276(22):19431-9. PMID: 11278875.
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      59. Miller Y, Shaklai N. Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation. Biochim Biophys Acta. 1999 Jul 07; 1454(2):153-64. PMID: 10381560.
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      60. Altamentova SM, Shaklai N, Arav R, Miller Y. A fluorescence method for estimation of toxemia: binding capacity of lipoproteins and albumin in plasma. Clin Chim Acta. 1998 Mar 23; 271(2):133-49. PMID: 9565329.
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      61. Miller Y, Altamentova SM, Shaklai N. Oxidation of low-density lipoprotein by hemoglobin stems from a heme-initiated globin radical: antioxidant role of haptoglobin. Biochemistry. 1997 Oct 07; 36(40):12189-98. PMID: 9315856.
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      62. Miller Y, Smith A, Morgan WT, Shaklai N. Role of hemopexin in protection of low-density lipoprotein against hemoglobin-induced oxidation. Biochemistry. 1996 Oct 08; 35(40):13112-7. PMID: 8855948.
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      63. Miller Y, Felikman Y, Shaklai N. Hemoglobin induced apolipoprotein B crosslinking in low-density lipoprotein peroxidation. Arch Biochem Biophys. 1996 Feb 15; 326(2):252-60. PMID: 8611031.
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      64. Miller Y, Felikman Y, Shaklai N. The involvement of low-density lipoprotein in hemin transport potentiates peroxidative damage. Biochim Biophys Acta. 1995 Oct 17; 1272(2):119-27. PMID: 7548235.
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      65. Miller Y, Shaklai N. Oxidative crosslinking of LDL protein induced by hemin: involvement of tyrosines. Biochem Mol Biol Int. 1994 Dec; 34(6):1121-9. PMID: 7696984.
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      66. Siegal GP, Wang MH, Rinehart CA, Kennedy JW, Goodly LJ, Miller Y, Kaufman DG, Singh RK. Development of a novel human extracellular matrix for quantitation of the invasiveness of human cells. Cancer Lett. 1993 Apr 30; 69(2):123-32. PMID: 8495401.
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