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    Xin Sun

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0766
    CA La Jolla 92093
    Phone858-246-2000
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      Collapse Biography 
      Collapse Education and Training
      UCSFPostdoc04/2002Developmental Genetics
      Yale UniversityPh.D.02/1997Developmental Biology

      Collapse Overview 
      Collapse Overview
      Research focus:
      The building of an organ starts from an amorphous cluster of cells, and proceeds following an elaborate blueprint of coordinated proliferation, morphogenesis and differentiation. Organ function relies on the harmonization with other organs, the infusion by blood and immune cells, and the wiring by the nervous system. We employ cutting edge techniques in modern biology, including genome editing, genomics, epigenomics, imaging and disease modeling, to delineate the robustness that dictates normal organ function, and uncover the imperfection that initiates pathogenesis.

      At the center of our investigation is the lung, an organ that is vital at first breath. It is the setting for many fetal, pediatric and adult diseases that have little explanation and no cure. We use disease modeling as a starting point for basic discoveries in developmental biology, stem cell biology and neural-immune interface with physiology.


      Collapse Research 
      Collapse Research Activities and Funding
      Foundational mapping of the neural circuits that control intrinsic lung function.
      NIH Office of Directors OT2OD023857Feb 1, 2017 - Jan 31, 2019
      Role: PI
      Foundational Mapping of the Neural Circuits that Control Intrinsic Lung Function
      NIH OT2OD023857Feb 1, 2017 - Jul 31, 2018
      Role: Principal Investigator
      Respiratory Deficiencies in Congenital Diaphragmatic Hernia
      NIH/NHLBI R01HL122406Aug 15, 2015 - May 31, 2019
      Role: Principal Investigator
      Respiratory deficiencies in congenital diaphragmatic hernia.
      NHLBI RO1HL122406Aug 1, 2015 - Jul 31, 2019
      Role: PI
      Cartilage and smooth muscle in airway tone and microenvironment.
      NHLBI R01HL119946Aug 1, 2014 - Jul 31, 2018
      Role: PI
      Cartilage and Smooth Muscle in Airway Tone and Microenvironment
      NIH/NHLBI R01HL119946Aug 1, 2014 - Apr 30, 2018
      Role: Principal Investigator
      FGF Signaling in Lung Maturation and Response to Injury
      NIH/NHLBI R01HL113870Apr 20, 2012 - Mar 31, 2017
      Role: Principal Investigator
      Program Project: GENE MUTATION AND RESCUE IN HUMAN DIAPHRAGMATIC HERNIA
      NIH/NICHD P01HD068250Jul 1, 2011 - Apr 30, 2022
      Role: Co-Principal Investigator
      Investigating the Interplay Between WNT and FGF Signaling in Prostate Initiation
      NIH/NIDDK R21DK082888Sep 30, 2009 - Jul 31, 2012
      Role: Principal Investigator
      Investigating Effects of Viral Infection on Lung Development
      NIH/NHLBI R01HL097134Sep 1, 2009 - Jul 31, 2014
      Role: Co-Principal Investigator
      Analysis of FGF Function in Limb Development
      NIH/NICHD R01HD045522Jul 1, 2004 - Apr 30, 2010
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Macatangay BJ, Yang M, Sun X, Morton J, De Gruttola V, Little S, Hogan C, Rinaldo CR. Brief Report: Changes in Levels of Inflammation After Antiretroviral Treatment During Early HIV Infection in AIDS Clinical Trials Group Study A5217. J Acquir Immune Defic Syndr. 2017 May 01; 75(1):137-141. PMID: 28198712.
        View in: PubMed
      2. Dai HQ, Wang BA, Yang L, Chen JJ, Zhu GC, Sun ML, Ge H, Wang R, Chapman DL, Tang F, Sun X, Xu GL. TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature. 2016 10 27; 538(7626):528-532. PMID: 27760115.
        View in: PubMed
      3. Zhang Y, Yokoyama S, Herriges JC, Zhang Z, Young RE, Verheyden JM, Sun X. E3 ubiquitin ligase RFWD2 controls lung branching through protein-level regulation of ETV transcription factors. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7557-62. PMID: 27335464; PMCID: PMC4941481 [Available on 01/05/17].
      4. Hines EA, Verheyden JM, Lashua AJ, Larson SC, Branchfield K, Domyan ET, Gao J, Harvey JF, Herriges JC, Hu L, Mcculley DJ, Throckmorton K, Yokoyama S, Ikeda A, Xu G, Sun X. Syndactyly in a novel Fras1(rdf) mutant results from interruption of signals for interdigital apoptosis. Dev Dyn. 2016 Apr; 245(4):497-507. PMID: 26813283; PMCID: PMC4860343 [Available on 04/01/17].
      5. Branchfield K, Nantie L, Verheyden JM, Sui P, Wienhold MD, Sun X. Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science. 2016 Feb 12; 351(6274):707-10. PMID: 26743624; PMCID: PMC4860346 [Available on 02/12/17].
      6. Branchfield K, Li R, Lungova V, Verheyden JM, McCulley D, Sun X. A three-dimensional study of alveologenesis in mouse lung. Dev Biol. 2016 Jan 15; 409(2):429-41. PMID: 26632490; PMCID: PMC4843524 [Available on 01/15/17].
      7. Herriges JC, Verheyden JM, Zhang Z, Sui P, Zhang Y, Anderson MJ, Swing DA, Zhang Y, Lewandoski M, Sun X. FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching. Dev Cell. 2015 Nov 09; 35(3):322-32. PMID: 26555052; PMCID: PMC4763945 [Available on 11/09/16].
      8. Lewis KJ, Tibbitt MW, Zhao Y, Branchfield K, Sun X, Balasubramaniam V, Anseth KS. In vitro model alveoli from photodegradable microsphere templates. Biomater Sci. 2015 Jun; 3(6):821-32. PMID: 26221842; PMCID: PMC4871129.
      9. McCulley D, Wienhold M, Sun X. The pulmonary mesenchyme directs lung development. Curr Opin Genet Dev. 2015 Jun; 32:98-105. PMID: 25796078; PMCID: PMC4763935.
      10. Lungova V, Verheyden JM, Herriges J, Sun X, Thibeault SL. Ontogeny of the mouse vocal fold epithelium. Dev Biol. 2015 Mar 15; 399(2):263-82. PMID: 25601450; PMCID: PMC4352410.
      11. Hines EA, Szakaly RJ, Leng N, Webster AT, Verheyden JM, Lashua AJ, Kendziorski C, Rosenthal LA, Gern JE, Sorkness RL, Sun X, Lemanske RF. Comparison of temporal transcriptomic profiles from immature lungs of two rat strains reveals a viral response signature associated with chronic lung dysfunction. PLoS One. 2014; 9(12):e112997. PMID: 25437859; PMCID: PMC4249857.
      12. Hines EA, Sun X. Tissue crosstalk in lung development. J Cell Biochem. 2014 Sep; 115(9):1469-77. PMID: 24644090.
        View in: PubMed
      13. Pham D, Sehra S, Sun X, Kaplan MH. The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation. J Allergy Clin Immunol. 2014 Jul; 134(1):204-14. PMID: 24486067; PMCID: PMC4209254.
      14. Hines EA, Jones MK, Verheyden JM, Harvey JF, Sun X. Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19444-9. PMID: 24218621; PMCID: PMC3845103.
      15. Sorkness RL, Szakaly RJ, Rosenthal LA, Sullivan R, Gern JE, Lemanske RF, Sun X. Viral bronchiolitis in young rats causes small airway lesions that correlate with reduced lung function. Am J Respir Cell Mol Biol. 2013 Nov; 49(5):808-13. PMID: 23763491; PMCID: PMC3931103.
      16. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. PMID: 23607856.
        View in: PubMed
      17. Mehta V, Schmitz CT, Keil KP, Joshi PS, Abler LL, Lin TM, Taketo MM, Sun X, Vezina CM. Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning. Dev Biol. 2013 Apr 15; 376(2):125-35. PMID: 23396188; PMCID: PMC3602957.
      18. Domyan ET, Branchfield K, Gibson DA, Naiche LA, Lewandoski M, Tessier-Lavigne M, Ma L, Sun X. Roundabout receptors are critical for foregut separation from the body wall. Dev Cell. 2013 Jan 14; 24(1):52-63. PMID: 23328398; PMCID: PMC3551250.
      19. Du Y, Liu B, Guo F, Xu G, Ding Y, Liu Y, Sun X, Xu G. The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS One. 2012; 7(10):e47358. PMID: 23077600; PMCID: PMC3471830.
      20. Herriges JC, Yi L, Hines EA, Harvey JF, Xu G, Gray PA, Ma Q, Sun X. Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep; 241(9):1432-53. PMID: 22711520; PMCID: PMC3529173.
      21. Bochkov YA, Palmenberg AC, Lee WM, Rathe JA, Amineva SP, Sun X, Pasic TR, Jarjour NN, Liggett SB, Gern JE. Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nat Med. 2011 May; 17(5):627-32. PMID: 21483405; PMCID: PMC3089712.
      22. Domyan ET, Ferretti E, Throckmorton K, Mishina Y, Nicolis SK, Sun X. Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Development. 2011 Mar; 138(5):971-81. PMID: 21303850; PMCID: PMC4074297.
      23. Zhang Z, O'Rourke JR, McManus MT, Lewandoski M, Harfe BD, Sun X. The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol. 2011 Mar 15; 351(2):254-65. PMID: 21256124; PMCID: PMC3541530.
      24. Domyan ET, Sun X. Patterning and plasticity in development of the respiratory lineage. Dev Dyn. 2011 Mar; 240(3):477-85. PMID: 21337460; PMCID: PMC3103759.
      25. Zhang Z, Sui P, Dong A, Hassell J, Cserjesi P, Chen YT, Behringer RR, Sun X. Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb. Development. 2010 Oct; 137(20):3417-26. PMID: 20826535; PMCID: PMC2947755.
      26. Harris-Johnson KS, Domyan ET, Vezina CM, Sun X. beta-Catenin promotes respiratory progenitor identity in mouse foregut. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16287-92. PMID: 19805295; PMCID: PMC2740732.
      27. Abler LL, Mansour SL, Sun X. Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung. Dev Dyn. 2009 Aug; 238(8):1999-2013. PMID: 19618463; PMCID: PMC3538083.
      28. Zhang Z, Verheyden JM, Hassell JA, Sun X. FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell. 2009 Apr; 16(4):607-13. PMID: 19386269; PMCID: PMC3541528.
      29. Norman RX, Ko HW, Huang V, Eun CM, Abler LL, Zhang Z, Sun X, Eggenschwiler JT. Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet. 2009 May 15; 18(10):1740-54. PMID: 19286674; PMCID: PMC2671991.
      30. Yi L, Domyan ET, Lewandoski M, Sun X. Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev Dyn. 2009 Jan; 238(1):123-37. PMID: 19097117; PMCID: PMC2853052.
      31. Verheyden JM, Sun X. An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Nature. 2008 Jul 31; 454(7204):638-41. PMID: 18594511; PMCID: PMC2840222.
      32. Harris KS, Zhang Z, McManus MT, Harfe BD, Sun X. Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2208-13. PMID: 16452165; PMCID: PMC1413733.
      33. Sun X, Barolo S, Bilder D, Montgomery M, Sinha N. Emerging from the fog: hypotheses and paradigms in developmental biology--the Society for Developmental Biology 2005 Annual Meeting Report. Dev Biol. 2006 Jan 15; 289(2):273-82. PMID: 16337185.
        View in: PubMed
      34. Verheyden JM, Lewandoski M, Deng C, Harfe BD, Sun X. Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development. 2005 Oct; 132(19):4235-45. PMID: 16120640.
        View in: PubMed
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