William Mobley

Title(s)Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Multiplexed Single Nucleus RNA and ATAC-seq Sequencing and Cortical Organoids: Transformative Insights into Down Syndrome
    NIH R01AG070154Sep 15, 2020 - Jun 30, 2025
    Role: Co-Principal Investigator
    Antisense Oligonucleotides targeting APP to prevent neurodegeneration in models of Down Syndrome and Alzheimer's disease
    NIH R01AG061151Apr 15, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Treating with Gamma-Secretase Modulators to Prevent Neurodegeneration in Mouse Models of Down Syndrome and Alzheimer Disease
    NIH R01AG055523May 1, 2018 - Jan 31, 2023
    Role: Principal Investigator
    From Structure to Therapy: The TRiC Chaperonin Network in Huntington's Disease
    NIH P01NS092525Apr 1, 2016 - Mar 31, 2021
    Role: Co-Investigator
    Genetic Basis of Failed Cognition in Young and Aged Mouse Models of Trisomy 21
    NIH R01NS066072Sep 30, 2010 - Jul 31, 2017
    Role: Principal Investigator
    2009 Neurotrophic Factors Gordon Research Conference
    NIH R13NS065502Apr 1, 2009 - Mar 31, 2010
    Role: Principal Investigator
    Disrupted Transport of NGF-TrKA Signaling in Mouse Models of Down Syndrome
    NIH R01NS055371May 7, 2007 - Apr 30, 2012
    Role: Principal Investigator
    Training in Translational Develomental Neuroscience
    NIH K12NS049648Aug 15, 2004 - Jun 30, 2010
    Role: Principal Investigator
    University of California San Diego Neuroscience Microscopy Imaging Core
    NIH P30NS047101Sep 30, 2003 - Nov 30, 2021
    Role: Principal Investigator
    MAPPING DS RELATED CNS PHENOTYPES
    NIH R01NS038869Mar 1, 1999 - Feb 28, 2005
    Role: Principal Investigator
    Alzheimer's Disease Cooperative Study
    NIH U19AG010483Jul 1, 1997 - Feb 28, 2021
    Role: Principal Investigator
    Translating discoveries in neurological diseases of infancy and childhood
    NIH K12NS001692Jul 1, 1993 - Jun 30, 2019
    Role: Principal Investigator
    NEUROTROPHIC FACTOR THERAPY FOR ALZHEIMERS DISEASE
    NIH R01AG010672Sep 29, 1991 - Jun 30, 1997
    Role: Principal Investigator
    Scientific Review and Evaluation Award - NST Committee
    NIH U09NS030469Jul 1, 1991 - Aug 31, 2006
    Role: Principal Investigator
    Nerve Growth Factor-Mechanisms for Signal Transduction
    NIH R01NS024054Jul 1, 1986 - Sep 30, 2009
    Role: Principal Investigator
    NERVE GROWTH FACTOR--EFFECTS ON DEVELOPING CNS NEURONS
    NIH K08NS001015Jul 1, 1985 - Jun 30, 1988
    Role: Principal Investigator
    3 D Electron Microscopy of Macromolecules
    NIH P41RR002250Mar 1, 1985 - Dec 31, 2014
    Role: Co-Investigator
    NGF SIGNALING IN MODELS OF AGE RELATED NEURODEGENERATION
    NIH R01AG016999Aug 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease. Neurobiol Dis. 2024 Apr 10; 106502. Gu Y, Pope A, Smith C, Carmona C, Johnstone A, Shi L, Chen X, Santos S, Bacon-Brenes CC, Shoff T, Kleczko KM, Frydman J, Thompson LM, Mobley WC, Wu C. PMID: 38608784.
      View in: PubMed   Mentions:
    2. Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration. Nat Aging. 2024 Mar 01. de Luzy IR, Lee MK, Mobley WC, Studer L. PMID: 38429379.
      View in: PubMed   Mentions: Translation:HumansCells
    3. WITHDRAWN: I feel your pain: Higher empathy is associated with higher posterior default mode network activity. bioRxiv. 2023 Dec 28. Oliva V, Riegner G, Dean J, Khatib LA, Allen A, Barrows D, Chen C, Fuentes R, Jacobson A, Lopez C, Mosbey D, Reyes M, Ross J, Uvarova A, Liu T, Mobley W, Zeidan F. PMID: 37645854; PMCID: PMC10462016.
      View in: PubMed   Mentions:
    4. Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease. Mol Brain. 2023 Nov 03; 16(1):75. Valdes P, Henry KW, Fitzgerald MQ, Muralidharan K, Caldwell AB, Ramachandran S, Goldstein LSB, Mobley WC, Galasko DR, Subramaniam S. PMID: 37924159; PMCID: PMC10623777.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling. bioRxiv. 2023 Oct 28. Zoltowska KM, Das U, Lismont S, Enzlein T, Maesako M, Houser MC, Franco ML, Moreira DG, Karachentsev D, Becker A, Hopf C, Vilar M, Berezovska O, Mobley W, Chávez-Gutiérrez L. PMID: 37577527; PMCID: PMC10418207.
      View in: PubMed   Mentions:
    6. Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain. Annu Rev Neurosci. 2023 07 10; 46:145-165. Fu XD, Mobley WC. PMID: 37428606.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior. Front Neurosci. 2023; 17:1202208. Overk C, Fiorini E, Babolin C, Vukicevic M, Morici C, Madani R, Eligert V, Kosco-Vilbois M, Roberts A, Becker A, Pfeifer A, Mobley WC. PMID: 37449271; PMCID: PMC10336548.
      View in: PubMed   Mentions:
    8. Reply to: Ptbp1 deletion does not induce astrocyte-to-neuron conversion. Nature. 2023 Jun; 618(7964):E8-E13. Hao Y, Hu J, Xue Y, Dowdy SF, Mobley WC, Qian H, Fu XD. PMID: 37286647.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    9. Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator. Ann Neurol. 2023 08; 94(2):245-258. Chen XQ, Sawa M, Becker A, Karachentsev D, Zuo X, Rynearson KD, Tanzi RE, Mobley WC. PMID: 37042072.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Editorial: Current advances in the study of Down Syndrome: From development to aging. Front Neurosci. 2023; 17:1161147. Johnstone A, Mobley W. PMID: 37021132; PMCID: PMC10067897.
      View in: PubMed   Mentions: 1  
    11. BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons. Elife. 2023 02 24; 12. Moya-Alvarado G, Tiburcio-Felix R, Ibáñez MR, Aguirre-Soto AA, Guerra MV, Wu C, Mobley WC, Perlson E, Bronfman FC. PMID: 36826992; PMCID: PMC9977295.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    12. CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons. Nat Commun. 2023 02 08; 14(1):692. Wu GH, Smith-Geater C, Galaz-Montoya JG, Gu Y, Gupte SR, Aviner R, Mitchell PG, Hsu J, Miramontes R, Wang KQ, Geller NR, Hou C, Danita C, Joubert LM, Schmid MF, Yeung S, Frydman J, Mobley W, Wu C, Thompson LM, Chiu W. PMID: 36754966; PMCID: PMC9908936.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    13. Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose. Alzheimers Dement. 2023 05; 19(5):2095-2116. Chen XQ, Zuo X, Becker A, Head E, Mobley WC. PMID: 36370135; PMCID: PMC10175517.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    14. Learning to Practice Compassionate Care: Medical Students Discuss Their Most Memorable Lessons. J Patient Exp. 2022; 9:23743735221117383. Schairer CE, Tutjer J, Cannavino C, Mobley WC, Eyler L, Bloss CS. PMID: 35957650; PMCID: PMC9358344.
      View in: PubMed   Mentions: 1  
    15. Disentangling self from pain: mindfulness meditation-induced pain relief is driven by thalamic-default mode network decoupling. Pain. 2023 02 01; 164(2):280-291. Riegner G, Posey G, Oliva V, Jung Y, Mobley W, Zeidan F. PMID: 36095039; PMCID: PMC9823141.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    16. Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial. JAMA Neurol. 2022 06 01; 79(6):565-574. Rafii MS, Sol O, Mobley WC, Delpretti S, Skotko BG, Burke AD, Sabbagh MN, Yuan SH, Rissman RA, Pulsifer M, Evans C, Evans AC, Beth G, Fournier N, Gray JA, Dos Santos AM, Hliva V, Vukicevic M, Kosco-Vilbois M, Streffer J, Pfeifer A, Feldman HH. PMID: 35532913; PMCID: PMC9086937.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    17. Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders. Annu Rev Pharmacol Toxicol. 2022 01 06; 62:211-233. Bartesaghi R, Vicari S, Mobley WC. PMID: 34990205; PMCID: PMC9632639.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    18. Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021 Dec; 23(4):572-573. Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E. PMID: 33948879; PMCID: PMC8096136.
      View in: PubMed   Mentions:    Fields:    
    19. Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021 Dec; 23(4):574-575. Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E. PMID: 34797469; PMCID: PMC8602985.
      View in: PubMed   Mentions: 1     Fields:    
    20. Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model. Alzheimers Dement. 2022 06; 18(6):1203-1234. Sawa M, Overk C, Becker A, Derse D, Albay R, Weldy K, Salehi A, Beach TG, Doran E, Head E, Yu YE, Mobley WC. PMID: 34757693; PMCID: PMC9085977.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    21. Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome. Front Aging Neurosci. 2021; 13:700280. Chen XQ, Xing Z, Chen QD, Salvi RJ, Zhang X, Tycko B, Mobley WC, Yu YE. PMID: 34276349; PMCID: PMC8281234.
      View in: PubMed   Mentions: 4  
    22. Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome. Front Immunol. 2021; 12:621440. Illouz T, Biragyn A, Iulita MF, Flores-Aguilar L, Dierssen M, De Toma I, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, London J, Mobley W, Strydom A, Okun E. PMID: 34248930; PMCID: PMC8267813.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    23. Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society. Mol Syndromol. 2021 Jul; 12(4):202-218. Dierssen M, Herault Y, Helguera P, Martínez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EMC, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, Abbeduto L, Del Hoyo Soriano L, Busciglio J, Iulita MF, Crispino J, Malinge S, Barone E, Perluigi M, Costanzo F, Delabar JM, Bartesaghi R, Dekker AD, De Deyn P, Fortea Ormaechea J, Shaw PA, Haydar TF, Sherman SL, Strydom A, Bhattacharyya A. PMID: 34421499; PMCID: PMC8339505.
      View in: PubMed   Mentions: 2  
    24. Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. J Clin Med. 2021 Apr 28; 10(9). Hendrix JA, Airey DC, Britton A, Burke AD, Capone GT, Chavez R, Chen J, Chicoine B, Costa ACS, Dage JL, Doran E, Esbensen A, Evans CL, Faber KM, Foroud TM, Hart S, Haugen K, Head E, Hendrix S, Hillerstrom H, Kishnani PS, Krell K, Ledesma DL, Lai F, Lott I, Ochoa-Lubinoff C, Mason J, Nicodemus-Johnson J, Proctor NK, Pulsifer MB, Revta C, Rosas HD, Rosser TC, Santoro S, Schafer K, Scheidemantel T, Schmitt F, Skotko BG, Stasko MR, Talboy A, Torres A, Wilmes K, Woodward J, Zimmer JA, Feldman HH, Mobley W. PMID: 33924960; PMCID: PMC8124643.
      View in: PubMed   Mentions: 10  
    25. Opportunities, barriers, and recommendations in down syndrome research. Transl Sci Rare Dis. 2021; 5(3-4):99-129. Hendrix JA, Amon A, Abbeduto L, Agiovlasitis S, Alsaied T, Anderson HA, Bain LJ, Baumer N, Bhattacharyya A, Bogunovic D, Botteron KN, Capone G, Chandan P, Chase I, Chicoine B, Cieuta-Walti C, DeRuisseau LR, Durand S, Esbensen A, Fortea J, Giménez S, Granholm AC, Hahn LJ, Head E, Hillerstrom H, Jacola LM, Janicki MP, Jasien JM, Kamer AR, Kent RD, Khor B, Lawrence JB, Lemonnier C, Lewanda AF, Mobley W, Moore PE, Nelson LP, Oreskovic NM, Osorio RS, Patterson D, Rasmussen SA, Reeves RH, Roizen N, Santoro S, Sherman SL, Talib N, Tapia IE, Walsh KM, Warren SF, White AN, Wong GW, Yi JS. PMID: 34268067; PMCID: PMC8279178.
      View in: PubMed   Mentions: 21  
    26. Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention. J Exp Med. 2021 04 05; 218(4). Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. PMID: 33651103; PMCID: PMC7931646.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    27. Specialty clinics for adults with Down syndrome: A clinic survey. Am J Med Genet A. 2021 06; 185(6):1767-1775. Santoro SL, Campbell A, Balasubramanian A, Haugen K, Schafer K, Mobley W. PMID: 33729670.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    28. Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport. Alzheimers Res Ther. 2021 03 10; 13(1):59. Chen XQ, Das U, Park G, Mobley WC. PMID: 33691783; PMCID: PMC7945332.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    29. Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021 12; 23(4):561-571. Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E. PMID: 33660221; PMCID: PMC7929736.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic Health
    30. Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome. Sci Rep. 2020 12 07; 10(1):21323. Takahashi T, Sakai N, Iwasaki T, Doyle TC, Mobley WC, Nishino S. PMID: 33288820; PMCID: PMC7721723.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    31. Editorial for the special issue neurotrophic factors. Cell Tissue Res. 2020 10; 382(1):1-4. Saarma M, Mobley W, Leßmann V. PMID: 32974736.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    32. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimers Dement. 2021 02; 17(2):271-292. Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. PMID: 32975365; PMCID: PMC7984396.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    33. Local TrkB signaling: themes in development and neural plasticity. Cell Tissue Res. 2020 Oct; 382(1):101-111. Johnstone A, Mobley W. PMID: 32936344.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    34. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Bioorg Med Chem. 2020 11 15; 28(22):115734. Rynearson KD, Buckle RN, Herr RJ, Mayhew NJ, Chen X, Paquette WD, Sakwa SA, Yang J, Barnes KD, Nguyen P, Mobley WC, Johnson G, Lin JH, Tanzi RE, Wagner SL. PMID: 33007551; PMCID: PMC7917164.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    35. Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 Aug; 584(7820):E17. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32724206.
      View in: PubMed   Mentions: 2     Fields:    
    36. Minocycline Topical Foam: A New Drug for the Treatment of Acne. Ann Pharmacother. 2021 01; 55(1):105-110. Onge ES, Mobley WC. PMID: 32618475.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    37. Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis. J Neurosci. 2020 07 29; 40(31):5908-5921. Stupack J, Xiong XP, Jiang LL, Zhang T, Zhou L, Campos A, Ranscht B, Mobley W, Pasquale EB, Xu H, Huang TY. PMID: 32601248; PMCID: PMC7392511.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    38. Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 06; 582(7813):550-556. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32581380; PMCID: PMC7521455.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansAnimalsCells
    39. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimers Dement. 2020 07; 16(7):1065-1077. Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, Mobley W, Mufson EJ, Potter H, Zaman SH, Granholm AC, Rosas HD, Strydom A, Whitten MS, Rafii MS. PMID: 32544310; PMCID: PMC8865308.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    40. (H)Elping nerve growth factor: Elp1 inhibits TrkA's phosphatase to maintain retrograde signaling. J Clin Invest. 2020 05 01; 130(5):2195-2198. Kaplan DR, Mobley WC. PMID: 32281945; PMCID: PMC7190902.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    41. Enabling Technologies for Personalized and Precision Medicine. Trends Biotechnol. 2020 05; 38(5):497-518. Ho D, Quake SR, McCabe ERB, Chng WJ, Chow EK, Ding X, Gelb BD, Ginsburg GS, Hassenstab J, Ho CM, Mobley WC, Nolan GP, Rosen ST, Tan P, Yen Y, Zarrinpar A. PMID: 31980301; PMCID: PMC7924935.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    42. Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species. Front Neurosci. 2019; 13:659. Chen XQ, Mobley WC. PMID: 31293377; PMCID: PMC6598402.
      View in: PubMed   Mentions: 105  
    43. Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses. Front Neurosci. 2019; 13:446. Chen XQ, Mobley WC. PMID: 31133787; PMCID: PMC6514132.
      View in: PubMed   Mentions: 61  
    44. c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling. Sci Rep. 2019 04 15; 9(1):6070. Escudero CA, Cabeza C, Moya-Alvarado G, Maloney MT, Flores CM, Wu C, Court FA, Mobley WC, Bronfman FC. PMID: 30988348; PMCID: PMC6465280.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    45. Down syndrome. Handb Clin Neurol. 2019; 167:321-336. Rafii MS, Kleschevnikov AM, Sawa M, Mobley WC. PMID: 31753140.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    46. T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation. Traffic. 2018 11; 19(11):840-853. Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. PMID: 30120810; PMCID: PMC6191364.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    47. Trends in Readmission Rates, Hospital Charges, and Mortality for Patients With Chronic Obstructive Pulmonary Disease (COPD) in Florida From 2009 to 2014. Clin Ther. 2018 04; 40(4):613-626.e1. Jiang X, Xiao H, Segal R, Mobley WC, Park H. PMID: 29609879.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    48. Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception. J Neurosci. 2018 04 04; 38(14):3394-3413. Sung K, Ferrari LF, Yang W, Chung C, Zhao X, Gu Y, Lin S, Zhang K, Cui B, Pearn ML, Maloney MT, Mobley WC, Levine JD, Wu C. PMID: 29483280; PMCID: PMC5895035.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    49. Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits. Br J Anaesth. 2018 Apr; 120(4):745-760. Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Patel PM, Head BP. PMID: 29576115; PMCID: PMC6200100.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    50. Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome. Free Radic Biol Med. 2018 01; 114:52-61. Chen XQ, Sawa M, Mobley WC. PMID: 29031834; PMCID: PMC5748266.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    51. Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series. Int J Mol Sci. 2017 May 26; 18(6). Bradshaw RA, Bradshaw RA, Mobley W, Rush RA. PMID: 28587118; PMCID: PMC5485967.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    52. Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 07; 362(1):31-44. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. PMID: 28416568; PMCID: PMC5454592.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    53. Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2017 Jul; 103:1-10. Kleschevnikov AM, Yu J, Kim J, Lysenko LV, Zeng Z, Yu YE, Mobley WC. PMID: 28342823; PMCID: PMC5446050.
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    54. PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI). J Alzheimers Dis. 2017; 60(2):439-450. Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman RA, Strother SC, Wernick MN, Pennington C, Mobley WC, Ness S, Matthews DC, Down Syndrome Biomarker Initiative and the Alzheimer’s Disease Neuroimaging Initiative. PMID: 28946567.
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    55. Mouse-based genetic modeling and analysis of Down syndrome. Br Med Bull. 2016 12; 120(1):111-122. Xing Z, Li Y, Pao A, Bennett AS, Tycko B, Mobley WC, Yu YE. PMID: 27789459; PMCID: PMC5146682.
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    56. GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App. Hippocampus. 2016 12; 26(12):1641-1654. Mojabi FS, Fahimi A, Moghadam S, Moghadam S, Windy McNerneny M, Ponnusamy R, Kleschevnikov A, Mobley WC, Salehi A. PMID: 27701794.
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    57. TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5655-64. Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC. PMID: 27601642; PMCID: PMC5035849.
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    58. Dissociation of Down syndrome and Alzheimer's disease effects with imaging. Alzheimers Dement (N Y). 2016 Jun; 2(2):69-81. Matthews DC, Lukic AS, Andrews RD, Marendic B, Brewer J, Rissman RA, Mosconi L, Strother SC, Wernick MN, Mobley WC, Ness S, Schmidt ME, Rafii MS. PMID: 28642933; PMCID: PMC5477635.
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    59. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genet. 2016 05; 12(5):e1006033. Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ. PMID: 27195491; PMCID: PMC4873152.
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    60. Dementia in Down's syndrome. Lancet Neurol. 2016 05; 15(6):622-36. Ballard C, Mobley W, Hardy J, Williams G, Corbett A. PMID: 27302127.
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    61. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest. 2016 05 02; 126(5):1815-33. Xu W, Weissmiller AM, White JA, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C. PMID: 27064279; PMCID: PMC4855914.
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    62. An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. PLoS One. 2016; 11(3):e0152471. Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SK, Linke GR, Maloney MT, Hickman DT, Reis P, Granet A, Mlaki D, Lopez-Deber MP, Do L, Singhal N, Masliah E, Pearn ML, Pfeifer A, Muhs A, Mobley WC. PMID: 27023444; PMCID: PMC4811554.
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    63. Genetic dissection of the Down syndrome critical region. Hum Mol Genet. 2015 Nov 15; 24(22):6540-51. Jiang X, Liu C, Yu T, Zhang L, Meng K, Xing Z, Belichenko PV, Kleschevnikov AM, Pao A, Peresie J, Wie S, Mobley WC, Yu YE. PMID: 26374847; PMCID: PMC4614710.
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    64. The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Front Behav Neurosci. 2015; 9:239. Rafii MS, Wishnek H, Brewer JB, Donohue MC, Ness S, Mobley WC, Aisen PS, Rissman RA. PMID: 26441570; PMCID: PMC4568340.
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    65. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 2015 Sep 02; 87(5):963-75. Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, St George-Hyslop P, Masliah E, Fraser P, Xu H. PMID: 26335643; PMCID: PMC4575284.
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    66. Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues. PLoS One. 2015; 10(7):e0134861. Belichenko PV, Kleschevnikov AM, Becker A, Wagner GE, Lysenko LV, Yu YE, Mobley WC. PMID: 26230397; PMCID: PMC4521889.
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    67. Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome. F1000Res. 2015; 4:269. Do LH, Mobley WC, Singhal N. PMID: 26664707; PMCID: PMC4654439.
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    68. Single Figure Publications: Towards a novel alternative format for scholarly communication. F1000Res. 2015; 4:268. Do L, Mobley W. PMID: 27506233; PMCID: PMC4786890.
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    69. Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome. Neurobiol Dis. 2015 May; 77:173-90. Nosheny RL, Belichenko PV, Busse BL, Weissmiller AM, Dang V, Das D, Fahimi A, Salehi A, Smith SJ, Mobley WC. PMID: 25753471; PMCID: PMC4689307.
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    70. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379. Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. PMID: 25710492; PMCID: PMC4339551.
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    71. Rat embryonic hippocampus and induced pluripotent stem cell derived cultured neurons recover from laser-induced subaxotomy. Neurophotonics. 2015 Jan; 2(1):015006. Selfridge A, Hyun N, Chiang CC, Reyna SM, Weissmiller AM, Shi LZ, Preece D, Mobley WC, Berns MW. PMID: 26157985; PMCID: PMC4487718.
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    72. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimers Dement. 2015 Jun; 11(6):700-9. Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, Reeves R, Sabbagh M, Silverman W, Tycko B, Whitten M, Wisniewski T. PMID: 25510383; PMCID: PMC4817997.
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    73. 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimers Dement. 2014 Oct; 10(5 Suppl):S430-52. Alzheimer's Association National Plan Milestone Workgroup, Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Yaffe K, Bain LJ, Thies WH, Carrillo MC. PMID: 25341459.
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    74. Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons. J Vis Exp. 2014 Sep 15; (91):51899. Zhao X, Zhou Y, Weissmiller AM, Pearn ML, Mobley WC, Wu C. PMID: 25286194; PMCID: PMC4828072.
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    75. Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography. J Vis Exp. 2014 Feb 12; (84):e50783. Shahmoradian SH, Galiano MR, Wu C, Chen S, Rasband MN, Mobley WC, Chiu W. PMID: 24561719; PMCID: PMC4089403.
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    76. Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 2014 Feb 04; 53(4):702-13. Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. PMID: 24401146; PMCID: PMC3929337.
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    77. Rita Levi-Montalcini: the story of an uncommon intellect and spirit. Neuroscience. 2013 Nov 12; 252:431-7. Chao M, Cattaneo A, Mobley W. PMID: 24288807.
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    78. The challenge of connecting the dots in the B.R.A.I.N. Neuron. 2013 Oct 16; 80(2):270-4. Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. PMID: 24139032; PMCID: PMC3864648.
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    79. Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. Hum Mol Genet. 2014 Feb 01; 23(3):578-89. Zhang L, Meng K, Jiang X, Liu C, Pao A, Belichenko PV, Kleschevnikov AM, Josselyn S, Liang P, Ye P, Mobley WC, Yu YE. PMID: 24041763; PMCID: PMC3888256.
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    80. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr; 19(4):473-80. Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H. PMID: 23524343; PMCID: PMC3911880.
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    81. Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry. 2013 May 10; 19(20):6398-408. Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA. PMID: 23526661; PMCID: PMC3875175.
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    82. Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome. J Alzheimers Dis Parkinsonism. 2013 Mar 20; Suppl 7:002. Decourt B, Mobley W, Reiman E, Shah RJ, Sabbagh MN. PMID: 24782952; PMCID: PMC4000700.
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    83. Aging and intellectual disability: insights from mouse models of Down syndrome. Dev Disabil Res Rev. 2013; 18(1):43-50. Ruparelia A, Pearn ML, Mobley WC. PMID: 23949828.
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    84. NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease. J Huntingtons Dis. 2013; 2(1):69-82. Zhang H, Petit GH, Gaughwin PM, Hansen C, Ranganathan S, Zuo X, Smith R, Roybon L, Brundin P, Mobley WC, Li JY. PMID: 25063430.
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    85. Potential use of γ-secretase modulators in the treatment of Alzheimer disease. Arch Neurol. 2012 Oct; 69(10):1255-8. Wagner SL, Tanzi RE, Mobley WC, Galasko D. PMID: 22801784; PMCID: PMC3747667.
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    86. Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. J Neurosci. 2012 Jul 04; 32(27):9217-27. Kleschevnikov AM, Belichenko PV, Faizi M, Jacobs LF, Htun K, Shamloo M, Mobley WC. PMID: 22764230; PMCID: PMC3411326.
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    87. Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome. Curr Opin Neurobiol. 2012 Oct; 22(5):880-6. Ruparelia A, Pearn ML, Mobley WC. PMID: 22658745; PMCID: PMC3434300.
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    88. Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioeng Bugs. 2012 Jan 01; 3(1):8-12. Zhang L, Fu D, Belichenko PV, Liu C, Kleschevnikov AM, Pao A, Liang P, Clapcote SJ, Mobley WC, Yu YE. PMID: 22126738; PMCID: PMC3329253.
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    89. The evolution of academic neurology: new information will bring new meaning. Arch Neurol. 2012 Mar; 69(3):308-14. Mobley W, N Rosenberg R. PMID: 22083800.
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    90. Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2012 Feb; 45(2):683-91. Kleschevnikov AM, Belichenko PV, Gall J, George L, Nosheny R, Maloney MT, Salehi A, Mobley WC. PMID: 22062771; PMCID: PMC3259223.
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    91. Mouse models for Down syndrome-associated developmental cognitive disabilities. Dev Neurosci. 2011; 33(5):404-13. Liu C, Belichenko PV, Zhang L, Fu D, Kleschevnikov AM, Baldini A, Antonarakis SE, Mobley WC, Yu YE. PMID: 21865664; PMCID: PMC3254039.
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    92. Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator. Org Lett. 2011 Sep 02; 13(17):4554-7. Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA. PMID: 21812392; PMCID: PMC3163030.
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    93. Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis. 2011 Aug; 43(2):397-413. Faizi M, Bader PL, Tun C, Encarnacion A, Kleschevnikov A, Belichenko P, Saw N, Priestley M, Tsien RW, Mobley WC, Shamloo M. PMID: 21527343; PMCID: PMC3539757.
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    94. Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem. 2011 May; 117(4):613-22. Rissman RA, Mobley WC. PMID: 21388375; PMCID: PMC3127285.
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    95. Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Res. 2010 Dec 17; 1366:162-71. Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, Kleschevnikov A, Bechard AR, Asrar S, Chen R, Fan N, Zhou Z, Jia Z, Chen C, Roder JC, Liu B, Baldini A, Mobley WC, Yu YE. PMID: 20932954; PMCID: PMC3027718.
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    96. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010 Sep 09; 67(5):769-80. Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. PMID: 20826309; PMCID: PMC2947312.
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    97. Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mamm Genome. 2010 Jun; 21(5-6):258-67. Yu T, Clapcote SJ, Li Z, Liu C, Pao A, Bechard AR, Carattini-Rivera S, Matsui S, Roder JC, Baldini A, Mobley WC, Bradley A, Yu YE. PMID: 20512340; PMCID: PMC3023176.
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    98. Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Sci Transl Med. 2009 Nov 18; 1(7):7ra17. Salehi A, Faizi M, Colas D, Valletta J, Laguna J, Takimoto-Kimura R, Kleschevnikov A, Wagner SL, Aisen P, Shamloo M, Mobley WC. PMID: 20368182.
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    99. Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell. 2009 Sep 04; 5(3):310-9. Tamaki SJ, Jacobs Y, Dohse M, Capela A, Cooper JD, Reitsma M, He D, Tushinski R, Belichenko PV, Salehi A, Mobley W, Gage FH, Huhn S, Tsukamoto AS, Weissman IL, Uchida N. PMID: 19733542.
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    100. The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome. Genet Med. 2009 Sep; 11(9):611-6. Mégarbané A, Ravel A, Mircher C, Sturtz F, Grattau Y, Rethoré MO, Delabar JM, Mobley WC. PMID: 19636252.
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    101. Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks. J Comp Neurol. 2009 May 20; 514(3):240-58. Belichenko PV, Wright EE, Belichenko NP, Masliah E, Li HH, Mobley WC, Francke U. PMID: 19296534.
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    102. The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J Neurosci. 2009 May 06; 29(18):5938-48. Belichenko NP, Belichenko PV, Kleschevnikov AM, Salehi A, Reeves RH, Mobley WC. PMID: 19420260; PMCID: PMC3849469.
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    103. Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. J Comp Neurol. 2009 Feb 01; 512(4):453-66. Belichenko PV, Kleschevnikov AM, Masliah E, Wu C, Takimoto-Kimura R, Salehi A, Mobley WC. PMID: 19034952; PMCID: PMC8480942.
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    104. Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation. Neurobiol Dis. 2009 Apr; 34(1):71-7. Belichenko NP, Belichenko PV, Mobley WC. PMID: 19167498.
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    105. The coming of age of axonal neurotrophin signaling endosomes. J Proteomics. 2009 Feb 15; 72(1):46-55. Wu C, Cui B, He L, Chen L, Mobley WC. PMID: 19028611; PMCID: PMC2677075.
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    106. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. J Neurosci. 2008 Sep 03; 28(36):9002-12. Wan J, Cheung AY, Fu WY, Wu C, Zhang M, Mobley WC, Cheung ZH, Ip NY. PMID: 18768694; PMCID: PMC6670871.
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    107. Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome. J Comp Neurol. 2008 May 01; 508(1):184-95. Belichenko NP, Belichenko PV, Li HH, Mobley WC, Francke U. PMID: 18306326.
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    108. Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit Rev Toxicol. 2008; 38 Suppl 2:1-125. Eaton DL, Daroff RB, Autrup H, Bridges J, Buffler P, Costa LG, Coyle J, McKhann G, Mobley WC, Nadel L, Neubert D, Schulte-Hermann R, Spencer PS. PMID: 18726789.
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    109. Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic. 2008 Feb; 9(2):215-29. Chial HJ, Wu R, Ustach CV, McPhail LC, Mobley WC, Chen YQ. PMID: 18034774; PMCID: PMC3810297.
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    110. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J Comp Neurol. 2007 Oct 01; 504(4):329-45. Belichenko PV, Kleschevnikov AM, Salehi A, Epstein CJ, Mobley WC. PMID: 17663443.
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    111. A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway. Traffic. 2007 Nov; 8(11):1503-20. Wu C, Ramirez A, Cui B, Ding J, Delcroix JD, Valletta JS, Liu JJ, Yang Y, Chu S, Mobley WC. PMID: 17822405.
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    112. One at a time, live tracking of NGF axonal transport using quantum dots. Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13666-71. Cui B, Wu C, Chen L, Ramirez A, Bearer EL, Li WP, Mobley WC, Chu S. PMID: 17698956; PMCID: PMC1959439.
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    113. Sleep and EEG features in genetic models of Down syndrome. Neurobiol Dis. 2008 Apr; 30(1):1-7. Colas D, Valletta JS, Takimoto-Kimura R, Nishino S, Fujiki N, Mobley WC, Mignot E. PMID: 18282758; PMCID: PMC4689324.
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    114. Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2223-8. Liu JJ, Ding J, Wu C, Bhagavatula P, Cui B, Chu S, Mobley WC, Yang Y. PMID: 17287360; PMCID: PMC1892971.
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    115. Using mouse models to explore genotype-phenotype relationship in Down syndrome. Ment Retard Dev Disabil Res Rev. 2007; 13(3):207-14. Salehi A, Faizi M, Belichenko PV, Mobley WC. PMID: 17910089.
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    116. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 06; 51(1):29-42. Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC. PMID: 16815330.
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    117. TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10444-10449. Miyamoto Y, Yamauchi J, Tanoue A, Wu C, Mobley WC. PMID: 16801538; PMCID: PMC1502477.
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    118. Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice. Gene Ther. 2006 Jun; 13(11):917-25. Watson G, Bastacky J, Belichenko P, Buddhikot M, Jungles S, Vellard M, Mobley WC, Kakkis E. PMID: 16482204.
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    119. Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. Hum Mol Genet. 2006 May 01; 15(9):1451-63. Ding J, Allen E, Wang W, Valle A, Wu C, Nardine T, Cui B, Yi J, Taylor A, Jeon NL, Chu S, So Y, Vogel H, Tolwani R, Mobley W, Yang Y. PMID: 16565160.
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    120. Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain. Mol Genet Metab. 2005 Sep-Oct; 86(1-2):141-9. Belichenko PV, Dickson PI, Passage M, Jungles S, Mobley WC, Kakkis ED. PMID: 16006167.
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    121. Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm Genome. 2005 Feb; 16(2):79-90. Villar AJ, Belichenko PV, Gillespie AM, Kozy HM, Mobley WC, Epstein CJ. PMID: 15859352.
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    122. Long-distance retrograde neurotrophic signaling. Curr Opin Neurobiol. 2005 Feb; 15(1):40-8. Howe CL, Mobley WC. PMID: 15721743.
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    123. Report on the 'Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C. Cytogenet Genome Res. 2005; 108(4):269-77. Gardiner K, Davisson MT, Pritchard M, Patterson D, Groner Y, Crnic LS, Antonarakis S, Mobley W. PMID: 15627744.
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    124. Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. J Comp Neurol. 2004 Dec 13; 480(3):281-98. Belichenko PV, Masliah E, Kleschevnikov AM, Villar AJ, Epstein CJ, Salehi A, Mobley WC. PMID: 15515178.
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    125. An AUPN/ANA survey of department leader opinions on the health of US academic neurology. Neurology. 2004 Oct 26; 63(8):1354-6. Rizzo M, Mobley WC. PMID: 15505148.
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    126. Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation. Brain Res. 2004 Oct 15; 1023(2):231-42. Pontikis CC, Cella CV, Parihar N, Lim MJ, Chakrabarti S, Mitchison HM, Mobley WC, Rezaie P, Pearce DA, Cooper JD. PMID: 15374749.
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    127. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci. 2004 Sep 15; 24(37):8153-60. Kleschevnikov AM, Belichenko PV, Villar AJ, Epstein CJ, Malenka RC, Mobley WC. PMID: 15371516; PMCID: PMC6729789.
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    128. Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I. Mol Genet Metab. 2004 Sep-Oct; 83(1-2):163-74. Kakkis E, McEntee M, Vogler C, Le S, Levy B, Belichenko P, Mobley W, Dickson P, Hanson S, Passage M. PMID: 15464431.
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    129. Going the distance, or not, with neurotrophin signals. Cell. 2004 Jul 23; 118(2):141-3. Reichardt LF, Mobley WC. PMID: 15260984.
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    130. Signaling endosome hypothesis: A cellular mechanism for long distance communication. J Neurobiol. 2004 Feb 05; 58(2):207-16. Howe CL, Mobley WC. PMID: 14704953.
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    131. Trafficking the NGF signal: implications for normal and degenerating neurons. Prog Brain Res. 2004; 146:3-23. Delcroix JD, Valletta J, Wu C, Howe CL, Lai CF, Cooper JD, Belichenko PV, Salehi A, Mobley WC. PMID: 14699953.
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    132. BPAG1n4 is essential for retrograde axonal transport in sensory neurons. J Cell Biol. 2003 Oct 27; 163(2):223-9. Liu JJ, Ding J, Kowal AS, Nardine T, Allen E, Delcroix JD, Wu C, Mobley W, Fuchs E, Yang Y. PMID: 14581450; PMCID: PMC2173519.
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    133. NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron. 2003 Jul 03; 39(1):69-84. Delcroix JD, Valletta JS, Wu C, Hunt SJ, Kowal AS, Mobley WC. PMID: 12848933.
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    134. Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends Neurosci. 2003 Feb; 26(2):73-80. Salehi A, Delcroix JD, Mobley WC. PMID: 12536130.
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    135. Ethics and the practice of brain science. Cerebrum. 2002; 4(3):64-6. Lo B, Albert MS, Hyman S, Parens E, Wolpe PR, Mobley W. PMID: 16619416.
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    136. NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron. 2001 Dec 06; 32(5):801-14. Howe CL, Valletta JS, Rusnak AS, Mobley WC. PMID: 11738027.
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    137. Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10439-44. Cooper JD, Salehi A, Delcroix JD, Howe CL, Belichenko PV, Chua-Couzens J, Kilbridge JF, Carlson EJ, Epstein CJ, Mobley WC. PMID: 11504920; PMCID: PMC56979.
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    138. Nerve growth factor activates persistent Rap1 signaling in endosomes. J Neurosci. 2001 Aug 01; 21(15):5406-16. Wu C, Lai CF, Mobley WC. PMID: 11466412; PMCID: PMC6762651.
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    139. The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA. J Biol Chem. 2001 Apr 06; 276(14):11294-301. Mischel PS, Smith SG, Vining ER, Valletta JS, Mobley WC, Reichardt LF. PMID: 11150291; PMCID: PMC2693057.
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    140. Neurotrophic factors as potential therapeutic agents in neuronal ceroid lipofuscinosis. Adv Genet. 2001; 45:169-82. Cooper JD, Mobley WC. PMID: 11332772.
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    141. NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking. J Neurosci. 2000 Oct 01; 20(19):7325-33. Beattie EC, Howe CL, Wilde A, Brodsky FM, Mobley WC. PMID: 11007890; PMCID: PMC6772792.
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    142. Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system. J Exp Med. 2000 May 15; 191(10):1799-806. Villoslada P, Hauser SL, Bartke I, Unger J, Heald N, Rosenberg D, Cheung SW, Mobley WC, Fisher S, Genain CP. PMID: 10811872; PMCID: PMC2193155.
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    143. Nerve growth factor signaling in caveolae-like domains at the plasma membrane. J Biol Chem. 1999 Dec 17; 274(51):36707-14. Huang CS, Zhou J, Feng AK, Lynch CC, Klumperman J, DeArmond SJ, Mobley WC. PMID: 10593976.
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    144. Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]. Neurobiol Dis. 1999 Oct; 6(5):321-34. Mitchison HM, Bernard DJ, Greene ND, Cooper JD, Junaid MA, Pullarkat RK, de Vos N, Breuning MH, Owens JW, Mobley WC, Gardiner RM, Lake BD, Taschner PE, Nussbaum RL. PMID: 10527801.
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    145. Early BDNF, NT-3, and NT-4 signaling events. Exp Neurol. 1999 Sep; 159(1):297-308. Yuen EC, Mobley WC. PMID: 10486198.
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    146. Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment. J Neurosci. 1999 Apr 01; 19(7):2556-67. Cooper JD, Messer A, Feng AK, Chua-Couzens J, Mobley WC. PMID: 10087069; PMCID: PMC6786069.
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    147. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell. 1999 Mar 05; 96(5):677-87. Wilde A, Beattie EC, Lem L, Riethof DA, Liu SH, Mobley WC, Soriano P, Brodsky FM. PMID: 10089883.
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    148. Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry. 1998 Dec 01; 37(48):16846-52. Butte MJ, Hwang PK, Mobley WC, Fletterick RJ. PMID: 9836577.
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    149. Doxycycline control of prion protein transgene expression modulates prion disease in mice. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12580-5. Tremblay P, Meiner Z, Galou M, Heinrich C, Petromilli C, Lisse T, Cayetano J, Torchia M, Mobley W, Bujard H, DeArmond SJ, Prusiner SB. PMID: 9770528; PMCID: PMC22873.
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    150. Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Exp Neurol. 1998 Jun; 151(2):314-25. Fagan AM, Murphy BA, Patel SN, Kilbridge JF, Mobley WC, Bu G, Holtzman DM. PMID: 9628766.
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    151. Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6256-61. Sago H, Carlson EJ, Smith DJ, Kilbridge J, Rubin EM, Mobley WC, Epstein CJ, Huang TT. PMID: 9600952; PMCID: PMC27649.
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    152. The effect of jet-milling on lyophilized liposomes. Pharm Res. 1998 Jan; 15(1):149-52. Mobley WC. PMID: 9487563.
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    153. Changes in the localization of brain prion proteins during scrapie infection. Neurology. 1998 Jan; 50(1):1271-80; discussion 2. DeArmond SJ, Mobley WC, DeMott DL, Barry RA, Beckstead JH, Prusiner SB. PMID: 9443448.
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    154. A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis. J Virol. 1997 Nov; 71(11):8821-31. Schätzl HM, Laszlo L, Holtzman DM, Tatzelt J, DeArmond SJ, Weiner RI, Mobley WC, Prusiner SB. PMID: 9343242; PMCID: PMC192348.
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    155. Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. J Neurosci. 1997 Oct 15; 17(20):7594-605. Yeo TT, Chua-Couzens J, Butcher LL, Bredesen DE, Cooper JD, Valletta JS, Mobley WC, Longo FM. PMID: 9315882; PMCID: PMC6793892.
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    156. A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA. Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9909-14. Grimes ML, Beattie E, Mobley WC. PMID: 9275225; PMCID: PMC23291.
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    157. Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes. J Neurosci. 1996 Dec 15; 16(24):7950-64. Grimes ML, Zhou J, Beattie EC, Yuen EC, Hall DE, Valletta JS, Topp KS, LaVail JH, Bunnett NW, Mobley WC. PMID: 8987823; PMCID: PMC6579208.
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    158. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13333-8. Holtzman DM, Santucci D, Kilbridge J, Chua-Couzens J, Fontana DJ, Daniels SE, Johnson RM, Chen K, Sun Y, Carlson E, Alleva E, Epstein CJ, Mobley WC. PMID: 8917591; PMCID: PMC24093.
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    159. Therapeutic potential of neurotrophic factors for neurological disorders. Ann Neurol. 1996 Sep; 40(3):346-54. Yuen EC, Mobley WC. PMID: 8797524.
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    160. Minimized hormones grow in stature. Nat Biotechnol. 1996 Sep; 14(9):1092. Longo FM, Mobley WC. PMID: 9631056.
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    161. Nerve growth factor and the neurotrophic factor hypothesis. Brain Dev. 1996 Sep-Oct; 18(5):362-8. Yuen EC, Howe CL, Li Y, Holtzman DM, Mobley WC. PMID: 8891230.
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    162. A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor. Brain Res Mol Brain Res. 1996 Jul; 39(1-2):185-97. Neve RL, Valletta JS, Li Y, Ventosa-Michelman M, Holtzman DM, Mobley WC. PMID: 8804727.
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    163. Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF. Neurochem Res. 1996 Jul; 21(7):861-8. Holtzman DM, Lee S, Li Y, Chua-Couzens J, Xia H, Bredt DS, Mobley WC. PMID: 8873091.
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    164. Recent progress in developmental neurology: exploring the bench to bedside interface. Curr Opin Neurol. 1996 Apr; 9(2):107-112. Mobley WC. PMID: 8782977.
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    165. A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration. Cold Spring Harb Symp Quant Biol. 1996; 61:389-406. Beattie EC, Zhou J, Grimes ML, Bunnett NW, Howe CL, Mobley WC. PMID: 9246468.
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    166. Abnormal plasma membrane properties and functions in prion-infected cell lines. Cold Spring Harb Symp Quant Biol. 1996; 61:531-40. DeArmond SJ, Qiu Y, Wong K, Nixon R, Hyun W, Prusiner SB, Mobley WC. PMID: 9246479.
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    167. Therapeutic applications of neurotrophic factors in disorders of motor neurons and peripheral nerves. Mol Med Today. 1995 Sep; 1(6):278-86. Yuen EC, Mobley WC. PMID: 9415162.
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    168. Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor. J Neurochem. 1995 Sep; 65(3):1146-56. Zhou J, Valletta JS, Grimes ML, Mobley WC. PMID: 7543930.
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    169. Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. J Neurosci. 1995 Apr; 15(4):2888-905. Li Y, Holtzman DM, Kromer LF, Kaplan DR, Chua-Couzens J, Clary DO, Knüsel B, Mobley WC. PMID: 7536822; PMCID: PMC6577746.
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    170. TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons. J Neurosci. 1995 Feb; 15(2):1567-76. Holtzman DM, Kilbridge J, Li Y, Cunningham ET, Lenn NJ, Clary DO, Reichardt LF, Mobley WC. PMID: 7869118; PMCID: PMC2710116.
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    171. Preliminary characterization of the central nervous system in partial trisomy 16 mice. Prog Clin Biol Res. 1995; 393:227-40. Holtzman DM, Kilbridge J, Chen KS, Rabin J, Luche R, Carlson E, Epstein CJ, Mobley WC. PMID: 8545453.
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    172. Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins. Exp Neurol. 1994 Dec; 130(2):178-95. Burke MA, Mobley WC, Cho J, Wiegand SJ, Lindsay RM, Mufson EJ, Kordower JH. PMID: 7867749.
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    173. NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin. Neurobiol Dis. 1994 Nov; 1(1-2):51-60. Holtzman DM, Kilbridge J, Bredt DS, Black SM, Li Y, Clary DO, Reichardt LF, Mobley WC. PMID: 9216986.
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    174. Neurotrophic factors and neurologic disease. West J Med. 1994 Sep; 161(3):246-54. Holtzman DM, Mobley WC. PMID: 7975562; PMCID: PMC1011405.
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    175. A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum. Int J Dev Neurosci. 1994 Jun; 12(4):255-62. Chen CK, Kinsman SL, Holtzman DM, Mobley WC, Johnston MV. PMID: 7976482.
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    176. Transgenic mouse brain histopathology resembles early Alzheimer's disease. Ann Neurol. 1994 May; 35(5):598-607. Higgins LS, Holtzman DM, Rabin J, Mobley WC, Cordell B. PMID: 7513982.
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    177. Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3824-8. Zhou J, Holtzman DM, Weiner RI, Mobley WC. PMID: 8170995; PMCID: PMC43674.
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    178. Isolation and characterization of a nerve growth factor-regulated Fos kinase from PC12 cells. J Biol Chem. 1994 Jan 07; 269(1):308-18. Taylor LK, Swanson KD, Kerigan J, Mobley W, Landreth GE. PMID: 8276812.
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    179. Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Neurology. 1993 Dec; 43(12):2668-73. Holtzman DM, Li Y, Chen K, Gage FH, Epstein CJ, Mobley WC. PMID: 8255474.
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    180. p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron. 1992 Sep; 9(3):465-78. Holtzman DM, Li Y, Parada LF, Kinsman S, Chen CK, Valletta JS, Zhou J, Long JB, Mobley WC. PMID: 1524827.
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    181. Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants. Proc Natl Acad Sci U S A. 1992 Feb 15; 89(4):1383-7. Holtzman DM, Li YW, DeArmond SJ, McKinley MP, Gage FH, Epstein CJ, Mobley WC. PMID: 1741393; PMCID: PMC48455.
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    182. Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome. EMBO J. 1992 Feb; 11(2):619-27. Holtzman DM, Bayney RM, Li YW, Khosrovi H, Berger CN, Epstein CJ, Mobley WC. PMID: 1371464; PMCID: PMC556494.
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    183. Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome. Prog Clin Biol Res. 1992; 379:227-44. Holtzman DM, Li Y, Gage FH, Epstein CJ, Mobley WC. PMID: 1409747.
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    184. Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates. Ann Neurol. 1991 Dec; 30(6):831-40. Koliatsos VE, Clatterbuck RE, Nauta HJ, Knüsel B, Burton LE, Hefti FF, Mobley WC, Price DL. PMID: 1789695.
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    185. Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor. Proc Natl Acad Sci U S A. 1991 Jun 15; 88(12):5144-8. Taiwo YO, Levine JD, Burch RM, Woo JE, Mobley WC. PMID: 1647026; PMCID: PMC51828.
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    186. Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat. Exp Neurol. 1991 May; 112(2):161-73. Koliatsos VE, Applegate MD, Knüsel B, Junard EO, Burton LE, Mobley WC, Hefti FF, Price DL. PMID: 2037030.
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    187. beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22. Biochemistry. 1991 Apr 09; 30(14):3443-50. Fahnestock M, Woo JE, Lopez GA, Snow J, Walz DA, Arici MJ, Mobley WC. PMID: 2012805.
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    188. Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor. J Neurosci. 1991 Apr; 11(4):943-55. Gold BG, Mobley WC, Matheson SF. PMID: 2010817; PMCID: PMC6575386.
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    189. Molecular studies in Alzheimer's disease. Trends Biochem Sci. 1991 Apr; 16(4):140-4. Holtzman DM, Mobley WC. PMID: 1877089.
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    190. A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord. Brain Res. 1991 Feb 08; 541(1):121-8. Koliatsos VE, Shelton DL, Mobley WC, Price DL. PMID: 1851446.
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    191. Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease. Prog Clin Biol Res. 1991; 373:189-202. Holtzman DM, Li YW, Gage FH, DeArmond SJ, Epstein CJ, McKinley MP, Mobley WC. PMID: 1838184.
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    192. Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey. J Neurosci. 1990 Dec; 10(12):3801-13. Koliatsos VE, Nauta HJ, Clatterbuck RE, Holtzman DM, Mobley WC, Price DL. PMID: 2269884; PMCID: PMC6570054.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    193. Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells. Exp Neurol. 1990 Dec; 110(3):274-83. Knüsel B, Burton LE, Longo FM, Mobley WC, Koliatsos VE, Price DL, Hefti F. PMID: 2249737.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    194. The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein. J Biol Chem. 1990 Jun 05; 265(16):8983-5. Sinha S, Dovey HF, Seubert P, Ward PJ, Blacher RW, Blaber M, Bradshaw RA, Arici M, Mobley WC, Lieberburg I. PMID: 2111813.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    195. In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain. J Neurosci. 1990 Jun; 10(6):1788-98. Burgin KE, Waxham MN, Rickling S, Westgate SA, Mobley WC, Kelly PT. PMID: 2162385; PMCID: PMC6570308.
      View in: PubMed   Mentions: 190     Fields:    Translation:AnimalsCells
    196. Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system. Prog Brain Res. 1990; 86:227-38. McKinley MP, Longo FM, Valletta JS, Rahbar F, Neve RL, Prusiner SB, Mobley WC. PMID: 1982367.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    197. The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides. Cell Regul. 1990 Jan; 1(2):189-95. Longo FM, Vu TK, Mobley WC. PMID: 2100197; PMCID: PMC361440.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    198. Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen. Neuron. 1989 Nov; 3(5):655-64. Mobley WC, Woo JE, Edwards RH, Riopelle RJ, Longo FM, Weskamp G, Otten U, Valletta JS, Johnston MV. PMID: 2561975.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    199. Acceleration of scrapie in neonatal Syrian hamsters. Neurology. 1989 Oct; 39(10):1319-24. McKinley MP, DeArmond SJ, Torchia M, Mobley WC, Prusiner SB. PMID: 2507957.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    200. Nerve growth factor in Alzheimer's disease: to treat or not to treat? Neurobiol Aging. 1989 Sep-Oct; 10(5):578-80; discussion 588-90. Mobley WC. PMID: 2812231.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    201. Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth. Brain Res. 1989 Jul 17; 492(1-2):245-54. Saffran BN, Woo JE, Mobley WC, Crutcher KA. PMID: 2752299.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    202. Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections. Neurosci Lett. 1989 May 22; 100(1-3):117-22. Sharp FR, Gonzalez MF, Hisanaga K, Mobley WC, Sagar SM. PMID: 2503789.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    203. Potential use of nerve growth factor to treat Alzheimer's disease. Neurobiol Aging. 1989 Mar-Apr; 10(2):205-7. Phelps CH, Gage FH, Growdon JH, Hefti F, Harbaugh R, Johnston MV, Khachaturian ZS, Mobley WC, Price DL, Raskind M, et al. PMID: 2657468.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    204. The effects of nerve growth factor on the development of septal cholinergic neurons in reaggregate cell cultures. Neuroscience. 1989; 29(1):209-23. Hsiang J, Heller A, Hoffmann PC, Mobley WC, Wainer BH. PMID: 2710345.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    205. PrPSc in scrapie-infected hamster brain is spatially and temporally related to histopathology and infectivity titer. Prog Clin Biol Res. 1989; 317:601-18. De Armond SJ, Gonzales M, Mobley WC, Kon AA, Stern A, Prusiner H, Prusiner SB. PMID: 2574872.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    206. Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9811-5. Mobley WC, Neve RL, Prusiner SB, McKinley MP. PMID: 2904679; PMCID: PMC282871.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    207. Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. I. Injection procedures modify pharmacological responses. J Pharmacol Exp Ther. 1988 Sep; 246(3):1158-66. Long JB, Mobley WC, Holaday JW. PMID: 2901486.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    208. Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. II. Nonopioid mechanisms mediate loss of motor, sensory and autonomic function. J Pharmacol Exp Ther. 1988 Sep; 246(3):1167-74. Long JB, Petras JM, Mobley WC, Holaday JW. PMID: 2901487.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    209. Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector. Mol Cell Biol. 1988 Jun; 8(6):2456-64. Edwards RH, Selby MJ, Mobley WC, Weinrich SL, Hruby DE, Rutter WJ. PMID: 3405211; PMCID: PMC363445.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    210. Infertility, chemical exposure, and farming in Iowa: absence of an association. Urology. 1988 Jan; 31(1):46-50. Gerber WL, de la Pena VE, Mobley WC. PMID: 3336927.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    211. NGF effects on developing forebrain cholinergic neurons are regionally specific. Neurochem Res. 1987 Nov; 12(11):985-94. Johnston MV, Rutkowski JL, Wainer BH, Long JB, Mobley WC. PMID: 3683745.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    212. Changes in the localization of brain prion proteins during scrapie infection. Neurology. 1987 Aug; 37(8):1271-80. DeArmond SJ, Mobley WC, DeMott DL, Barry RA, Beckstead JH, Prusiner SB. PMID: 3112607.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    213. Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons. Brain Res. 1986 Jul; 387(1):53-62. Mobley WC, Rutkowski JL, Tennekoon GI, Gemski J, Buchanan K, Johnston MV. PMID: 3742234.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    214. Use of intravesical cisplatin and mitomycin-C for recurrent transitional cell carcinoma of bladder refractory to thiotepa. Urology. 1986 Apr; 27(4):335-9. Mobley WC, Loening SA, Narayana AS, Culp DA. PMID: 3083555.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    215. Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates. Neuroscience. 1985 Nov; 16(3):691-9. Kitt CA, Struble RG, Cork LC, Mobley WC, Walker LC, Joh TH, Price DL. PMID: 2869445.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    216. Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor. Science. 1985 Jul 19; 229(4710):284-7. Mobley WC, Rutkowski JL, Tennekoon GI, Buchanan K, Johnston MV. PMID: 2861660.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    217. Evidence for cholinergic neurites in senile plaques. Science. 1984 Dec 21; 226(4681):1443-5. Kitt CA, Price DL, Struble RG, Cork LC, Wainer BH, Becher MW, Mobley WC. PMID: 6505701.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    218. Combination perineal cryosurgery and external radiation therapy for adenocarcinoma of prostate. Urology. 1984 Jul; 24(1):11-4. Mobley WC, Loening SA, Narayana AS. PMID: 6539996.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    219. Scientific overview of inflammatory demyelinating polyneuropathy and design of the North American collaborative study of plasma exchange in Guillain-Barre syndrome. Prog Clin Biol Res. 1982; 106:159-87. Mobley WC, Wolinsky JS. PMID: 6757937.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    220. Guillain-Barré syndrome: is there a role for plasmapheresis? Neurology. 1980 Oct; 30(10):1112. Asbury A, Fisher R, McKhann GM, Mobley W, Server A. PMID: 7191502.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    221. Localization of 2',3'-cyclic nucleotide-3'-phosphohydrolase of rabbit brain by sedimentation in a continuous sucrose gradient. J Neurochem. 1978 Apr; 30(4):735-44. Shapira R, Mobley WC, Thiele SB, Wilhelmi MR, Wallace A, Kibler RF. PMID: 206668.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    222. Nerve growth factor (third of three parts). N Engl J Med. 1977 Dec 01; 297(22):1211-8. Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM. PMID: 411033.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    223. Nerve growth factor (second of three parts). N Engl J Med. 1977 Nov 24; 297(21):1149-58. Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM. PMID: 72356.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    224. Nerve growth factor (first of three parts). N Engl J Med. 1977 Nov 17; 297(20):1096-104. Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM. PMID: 333290.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    225. Characterization and isolation of proteolytically modified nerve growth factor. Biochemistry. 1976 Dec 14; 15(25):5543-52. Mobley WC, Schenker A, Shooter EM. PMID: 999827.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    226. Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse. Brain Res. 1975 Aug 29; 94(2):263-77. Bjerre B, Björklund A, Mobley W, Rosengren E. PMID: 1148872.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    227. Effects of localized intracerebral injections of nerve growth factor on the regenerative growth of lesioned central noradrenergic neurones. Brain Res. 1974 Apr 05; 69(2):217-34. Stenevi U, Bjerre B, Björklund A, Mobley W. PMID: 4406332.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    228. Proteolytic modification of the beta nerve growth factor protein. Biochemistry. 1974 Feb 12; 13(4):833-40. Moore JB, Mobley WC, Shooter EM. PMID: 4811070.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    229. A stimulatory effect by nerve growth factor on the regrowth of adrenergic nerve fibres in the mouse peripheral tissues after chemical sympathectomy with 6-hydroxydopamine. Z Zellforsch Mikrosk Anat. 1973 Dec 31; 146(1):15-43. Bjerre B, Björklund A, Mobley W. PMID: 4777497.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
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