William Gerwick

Title(s)Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Development of an efficient cyanobacterial platform for heterologous expression and biosynthetic interrogations of natural products.
    NIH R01GM118815Jan 12, 2017 - Dec 31, 2020
    Role: Principal Investigator
    Development of Gallinamide A-Inspired Agents for the Treatment of Chagas? Disease
    NIH R21AI127505Dec 7, 2016 - Nov 30, 2019
    Role: Principal Investigator
    Unified Computation Tools for Natural Products Research
    NIH R01GM107550Sep 5, 2013 - Apr 30, 2025
    Role: Principal Investigator
    Huntington's Disease Natural Product Drug Discovery
    NIH R21AG038772Sep 1, 2011 - Aug 31, 2015
    Role: Principal Investigator
    Biosynthetic Analysis of Marine Cyanobacterial Pathways
    NIH R01CA108874Jul 1, 2004 - Mar 31, 2017
    Role: Principal Investigator
    ICBG: Training, Conservation and Drug Discovery using Panamanian Microorganisms
    NIH U01TW006634Sep 27, 2003 - Apr 30, 2015
    Role: Principal Investigator
    Training Program in Marine Biotechnology
    NIH T32GM067550Jul 1, 2003 - Jun 30, 2021
    Role: Principal Investigator
    US-Japan Seminar on Marine Bioorganic Chemistry
    NIH R13CA102377Jun 1, 2003 - May 31, 2004
    Role: Principal Investigator
    Neurotoxins from Marine Algae and Cyanobacteria
    NIH R01NS053398Jul 1, 2001 - Jun 30, 2017
    Role: Principal Investigator
    Neurotoxins from Marine Algae and Cyanobacteria
    NIH R01GM063554Jul 1, 2001 - Jun 30, 2005
    Role: Principal Investigator
    EICOSANOID BIOSYNTHESIS IN MARINE PLANTS
    NIH F06TW001616Jun 21, 1991
    Role: Principal Investigator
    Targeted Discovery of Marine-derived Anticancer Leads
    NIH U19CA052955Sep 1, 1990 - Apr 30, 2012
    Role: Co-Investigator
    SMALL INSTRUMENTATION PROGRAM
    NIH S15ES005267Aug 15, 1989 - Jul 31, 1990
    Role: Principal Investigator
    ANTINEOPLASTIC AGENTS FROM BLUE GREEN ALGAE
    NIH R23CA042850Jul 1, 1986 - Jun 30, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Light-gated Integrator for Highlighting Kinase Activity in Living Cells. bioRxiv. 2024 Mar 20. Lin W, Phatarphekar A, Zhong Y, Liu L, Kwon HB, Gerwick WH, Wang Y, Mehta S, Zhang J. PMID: 38562887; PMCID: PMC10983958.
      View in: PubMed   Mentions:
    2. PECAN Predicts Patterns of Cancer Cell Cytostatic Activity of Natural Products Using Deep Learning. J Nat Prod. 2024 Feb 13. Gahl M, Kim HW, Glukhov E, Gerwick WH, Cottrell GW. PMID: 38349959.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans. ACS Chem Biol. 2024 Mar 15; 19(3):619-628. Ngo TE, Ecker A, Ryu B, Guild A, Remmel A, Boudreau PD, Alexander KL, Naman CB, Glukhov E, Avalon NE, Shende VV, Thomas L, Dahesh S, Nizet V, Gerwick L, Gerwick WH. PMID: 38330248; PMCID: PMC10949194.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data. Nat Microbiol. 2024 Feb; 9(2):336-345. Zuffa S, Schmid R, Bauermeister A, P Gomes PW, Caraballo-Rodriguez AM, El Abiead Y, Aron AT, Gentry EC, Zemlin J, Meehan MJ, Avalon NE, Cichewicz RH, Buzun E, Terrazas MC, Hsu CY, Oles R, Ayala AV, Zhao J, Chu H, Kuijpers MCM, Jackrel SL, Tugizimana F, Nephali LP, Dubery IA, Madala NE, Moreira EA, Costa-Lotufo LV, Lopes NP, Rezende-Teixeira P, Jimenez PC, Rimal B, Patterson AD, Traxler MF, Pessotti RC, Alvarado-Villalobos D, Tamayo-Castillo G, Chaverri P, Escudero-Leyva E, Quiros-Guerrero LM, Bory AJ, Joubert J, Rutz A, Wolfender JL, Allard PM, Sichert A, Pontrelli S, Pullman BS, Bandeira N, Gerwick WH, Gindro K, Massana-Codina J, Wagner BC, Forchhammer K, Petras D, Aiosa N, Garg N, Liebeke M, Bourceau P, Kang KB, Gadhavi H, de Carvalho LPS, Silva Dos Santos M, Pérez-Lorente AI, Molina-Santiago C, Romero D, Franke R, Brönstrup M, Vera Ponce de León A, Pope PB, La Rosa SL, La Barbera G, Roager HM, Laursen MF, Hammerle F, Siewert B, Peintner U, Licona-Cassani C, Rodriguez-Orduña L, Rampler E, Hildebrand F, Koellensperger G, Schoeny H, Hohenwallner K, Panzenboeck L, Gregor R, O'Neill EC, Roxborough ET, Odoi J, Bale NJ, Ding S, Sinninghe Damsté JS, Guan XL, Cui JJ, Ju KS, Silva DB, Silva FMR, da Silva GF, Koolen HHF, Grundmann C, Clement JA, Mohimani H, Broders K, McPhail KL, Ober-Singleton SE, Rath CM, McDonald D, Knight R, Wang M, Dorrestein PC. PMID: 38316926; PMCID: PMC10847041.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Orthogonal Deprotection Strategy of Fmoc Provides Improved Synthesis of Sensitive Peptides: Application to Z-Arg-Lys-AOMK. ACS Omega. 2024 Jan 23; 9(3):3997-4003. Almaliti J, Alhindy M, Yoon MC, Hook V, Molinski TF, O'Donoghue AJ, Gerwick WH. PMID: 38284081; PMCID: PMC10809369.
      View in: PubMed   Mentions:
    6. Open access repository-scale propagated nearest neighbor suspect spectral library for untargeted metabolomics. Nat Commun. 2023 Dec 20; 14(1):8488. Bittremieux W, Avalon NE, Thomas SP, Kakhkhorov SA, Aksenov AA, Gomes PWP, Aceves CM, Caraballo-Rodríguez AM, Gauglitz JM, Gerwick WH, Huan T, Jarmusch AK, Kaddurah-Daouk RF, Kang KB, Kim HW, Kondic T, Mannochio-Russo H, Meehan MJ, Melnik AV, Nothias LF, O'Donovan C, Panitchpakdi M, Petras D, Schmid R, Schymanski EL, van der Hooft JJJ, Weldon KC, Yang H, Xing S, Zemlin J, Wang M, Dorrestein PC. PMID: 38123557; PMCID: PMC10733301.
      View in: PubMed   Mentions: 3     Fields:    
    7. Lake Avernus Has Turned Red: Bioindicator Monitoring Unveils the Secrets of "Gates of Hades". Toxins (Basel). 2023 Dec 13; 15(12). Esposito G, Glukhov E, Gerwick WH, Medio G, Teta R, Lega M, Costantino V. PMID: 38133202; PMCID: PMC10747548.
      View in: PubMed   Mentions:    Fields:    Translation:CellsPHPublic Health
    8. Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum. ACS Infect Dis. 2023 Oct 13; 9(10):2036-2047. Bennett JM, Ward KE, Muir RK, Kabeche S, Yoo E, Yeo T, Lam G, Zhang H, Almaliti J, Berger G, Faucher FF, Lin G, Gerwick WH, Yeh E, Fidock DA, Bogyo M. PMID: 37712594; PMCID: PMC10591878.
      View in: PubMed   Mentions:    Fields:    
    9. Artificial intelligence for natural product drug discovery. Nat Rev Drug Discov. 2023 11; 22(11):895-916. Mullowney MW, Duncan KR, Elsayed SS, Garg N, van der Hooft JJJ, Martin NI, Meijer D, Terlouw BR, Biermann F, Blin K, Durairaj J, Gorostiola González M, Helfrich EJN, Huber F, Leopold-Messer S, Rajan K, de Rond T, van Santen JA, Sorokina M, Balunas MJ, Beniddir MA, van Bergeijk DA, Carroll LM, Clark CM, Clevert DA, Dejong CA, Du C, Ferrinho S, Grisoni F, Hofstetter A, Jespers W, Kalinina OV, Kautsar SA, Kim H, Leao TF, Masschelein J, Rees ER, Reher R, Reker D, Schwaller P, Segler M, Skinnider MA, Walker AS, Willighagen EL, Zdrazil B, Ziemert N, Goss RJM, Guyomard P, Volkamer A, Gerwick WH, Kim HU, Müller R, van Wezel GP, van Westen GJP, Hirsch AKH, Linington RG, Robinson SL, Medema MH. PMID: 37697042.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. Enzymatic Halogenation of Terminal Alkynes. J Am Chem Soc. 2023 08 30; 145(34):18716-18721. Lukowski AL, Hubert FM, Ngo TE, Avalon NE, Gerwick WH, Moore BS. PMID: 37594919; PMCID: PMC10486310.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    11. Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors. bioRxiv. 2023 Aug 17. Silhan J, Fajtova P, Bartosova J, Hurysz BM, Almaliti J, Miyamoto Y, Eckmann L, Gerwick WH, O'Donoghue AJ, Boura E. PMID: 37645851; PMCID: PMC10462138.
      View in: PubMed   Mentions:
    12. DeepSAT: Learning Molecular Structures from Nuclear Magnetic Resonance Data. J Cheminform. 2023 Aug 07; 15(1):71. Kim HW, Zhang C, Reher R, Wang M, Alexander KL, Nothias LF, Han YK, Shin H, Lee KY, Lee KH, Kim MJ, Dorrestein PC, Gerwick WH, Cottrell GW. PMID: 37550756; PMCID: PMC10406729.
      View in: PubMed   Mentions:
    13. Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease. Front Pharmacol. 2023; 14:1190402. Boyarko B, Podvin S, Greenberg B, Momper JD, Huang Y, Gerwick WH, Bang AG, Quinti L, Griciuc A, Kim DY, Tanzi RE, Feldman HH, Hook V. PMID: 37601062; PMCID: PMC10436590.
      View in: PubMed   Mentions: 1  
    14. A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data. Res Sq. 2023 Aug 03. Zuffa S, Schmid R, Bauermeister A, Gomes PWP, Caraballo-Rodriguez AM, Abiead YE, Aron AT, Gentry EC, Zemlin J, Meehan MJ, Avalon NE, Cichewicz RH, Buzun E, Terrazas MC, Hsu CY, Oles R, Ayala AV, Zhao J, Chu H, Kuijpers MCM, Jackrel SL, Tugizimana F, Nephali LP, Dubery IA, Madala NE, Moreira EA, Costa-Lotufo LV, Lopes NP, Rezende-Teixeira P, Jimenez PC, Rimal B, Patterson AD, Traxler MF, de Cassia Pessotti R, Alvarado-Villalobos D, Tamayo-Castillo G, Chaverri P, Escudero-Leyva E, Quiros-Guerrero LM, Bory AJ, Joubert J, Rutz A, Wolfender JL, Allard PM, Sichert A, Pontrelli S, Pullman BS, Bandeira N, Gerwick WH, Gindro K, Massana-Codina J, Wagner BC, Forchhammer K, Petras D, Aiosa N, Garg N, Liebeke M, Bourceau P, Kang KB, Gadhavi H, de Carvalho LPS, Dos Santos MS, Pérez-Lorente AI, Molina-Santiago C, Romero D, Franke R, Brönstrup M, de León AVP, Pope PB, Rosa SL, Barbera G, Roager HM, Laursen MF, Hammerle F, Siewert B, Peintner U, Licona-Cassani C, Rodriguez-Orduña L, Rampler E, Hildebrand F, Koellensperger G, Schoeny H, Hohenwallner K, Panzenboeck L, Gregor R, O'Neill EC, Roxborough ET, Odoi J, Bale NJ, Ding S, Sinninghe Damsté JS, Guan XL, Cui JJ, Ju KS, Silva DB, Silva FMR, da Silva GF, Koolen HHF, Grundmann C, Clement JA, Mohimani H, Broders K, McPhail KL, Ober-Singleton SE, Rath CM, McDonald D, Knight R, Wang M, Dorrestein PC. PMID: 37577622; PMCID: PMC10418563.
      View in: PubMed   Mentions:
    15. Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from the Marine Cyanobacterium Moorena producens JHB Discovered via Co-culture with Candida albicans. bioRxiv. 2023 Jul 06. Ngo TE, Ecker A, Guild A, Remmel A, Boudreau PD, Alexander KL, Naman CB, Glukhov E, Avalon NE, Shende VV, Gerwick L, Gerwick WH. PMID: 37461655; PMCID: PMC10350029.
      View in: PubMed   Mentions:
    16. Methods in marine natural product drug discovery: what's new? Expert Opin Drug Discov. 2023 07; 18(7):687-691. Almaliti J, Gerwick WH. PMID: 37194298.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Development of subunit selective substrates for Trichomonas vaginalis proteasome. bioRxiv. 2023 Apr 06. Fajtova P, Hurysz BM, Miyamoto Y, Serafim M, Jiang Z, Trujillo DF, Liu L, Somani U, Almaliti J, Myers SA, Caffrey CR, Gerwick WH, Kirk CJ, Boura E, Eckmann L, O'Donoghue AJ. PMID: 37066163; PMCID: PMC10104049.
      View in: PubMed   Mentions:
    18. Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell Chem Biol. 2023 05 18; 30(5):470-485.e6. Deni I, Stokes BH, Ward KE, Fairhurst KJ, Pasaje CFA, Yeo T, Akbar S, Park H, Muir R, Bick DS, Zhan W, Zhang H, Liu YJ, Ng CL, Kirkman LA, Almaliti J, Gould AE, Duffey M, O'Donoghue AJ, Uhlemann AC, Niles JC, da Fonseca PCA, Gerwick WH, Lin G, Bogyo M, Fidock DA. PMID: 36963402; PMCID: PMC10198959.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    19. Development of Potent and Highly Selective Epoxyketone-Based Plasmodium Proteasome Inhibitors. Chemistry. 2023 Apr 06; 29(20):e202203958. Almaliti J, Fajtová P, Calla J, LaMonte GM, Feng M, Rocamora F, Ottilie S, Glukhov E, Boura E, Suhandynata RT, Momper JD, Gilson MK, Winzeler EA, Gerwick WH, O'Donoghue AJ. PMID: 36617500; PMCID: PMC10894724.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    20. Kalkitoxin: A Potent Suppressor of Distant Breast Cancer Metastasis. Int J Mol Sci. 2023 Jan 07; 24(2). Shrestha SK, Min KH, Kim SW, Kim H, Gerwick WH, Soh Y. PMID: 36674719.
      View in: PubMed   Mentions: 1     Fields:    
    21. Rapid Biotic and Abiotic Transformation of Toxins produced by Ostreopsis. cf. ovata. Mar Drugs. 2022 Nov 28; 20(12). Ternon E, Thomas OP, Lemée R, Gerwick WH. PMID: 36547895; PMCID: PMC9787646.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    22. NPOmix: A machine learning classifier to connect mass spectrometry fragmentation data to biosynthetic gene clusters. PNAS Nexus. 2022 Nov; 1(5):pgac257. Leão TF, Wang M, da Silva R, Gurevich A, Bauermeister A, Gomes PWP, Brejnrod A, Glukhov E, Aron AT, Louwen JJR, Kim HW, Reher R, Fiore MF, van der Hooft JJJ, Gerwick L, Gerwick WH, Bandeira N, Dorrestein PC. PMID: 36712343; PMCID: PMC9802219.
      View in: PubMed   Mentions: 2  
    23. Native metabolomics identifies the rivulariapeptolide family of protease inhibitors. Nat Commun. 2022 08 08; 13(1):4619. Reher R, Aron AT, Fajtová P, Stincone P, Wagner B, Pérez-Lorente AI, Liu C, Shalom IYB, Bittremieux W, Wang M, Jeong K, Matos-Hernandez ML, Alexander KL, Caro-Diaz EJ, Naman CB, Scanlan JHW, Hochban PMM, Diederich WE, Molina-Santiago C, Romero D, Selim KA, Sass P, Brötz-Oesterhelt H, Hughes CC, Dorrestein PC, O'Donoghue AJ, Gerwick WH, Petras D. PMID: 35941113; PMCID: PMC9358669.
      View in: PubMed   Mentions: 6     Fields:    
    24. Discovery of Novel Tyrosinase Inhibitors From Marine Cyanobacteria. Front Microbiol. 2022; 13:912621. He Y, Suyama TL, Kim H, Glukhov E, Gerwick WH. PMID: 35910604; PMCID: PMC9329053.
      View in: PubMed   Mentions:
    25. Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions. ACS Omega. 2022 Jul 26; 7(29):25346-25352. Phan VV, Mosier C, Yoon MC, Glukhov E, Caffrey CR, O'Donoghue AJ, Gerwick WH, Hook V. PMID: 35910167; PMCID: PMC9330179.
      View in: PubMed   Mentions:
    26. Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides. Nat Chem Biol. 2022 10; 18(10):1076-1086. Li FL, Fu V, Liu G, Tang T, Konradi AW, Peng X, Kemper E, Cravatt BF, Franklin JM, Wu Z, Mayfield J, Dixon JE, Gerwick WH, Guan KL. PMID: 35788180.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    27. Heterologous Expression in Anabaena of the Columbamide Pathway from the Cyanobacterium Moorena bouillonii and Production of New Analogs. ACS Chem Biol. 2022 07 15; 17(7):1910-1923. Taton A, Rohrer S, Diaz B, Reher R, Caraballo Rodriguez AM, Pierce ML, Dorrestein PC, Gerwick L, Gerwick WH, Golden JW. PMID: 35761435.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    28. Secondary Metabolite Variation and Bioactivities of Two Marine Aspergillus Strains in Static Co-Culture Investigated by Molecular Network Analysis and Multiple Database Mining Based on LC-PDA-MS/MS. Antibiotics (Basel). 2022 Apr 12; 11(4). Wang Y, Glukhov E, He Y, Liu Y, Zhou L, Ma X, Hu X, Hong P, Gerwick WH, Zhang Y. PMID: 35453264; PMCID: PMC9031932.
      View in: PubMed   Mentions: 9  
    29. On the Hunt for New Toxin Families Produced by a Mediterranean Strain of the Benthic Dinoflagellate Ostreopsis cf. ovata. Toxins (Basel). 2022 03 23; 14(4). Ternon E, Glukhov E, Trytten E, Lemée R, Gerwick WH. PMID: 35448843; PMCID: PMC9030729.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    30. Antillatoxin-Stimulated Neurite Outgrowth Involves the Brain-Derived Neurotrophic Factor (BDNF) - Tropomyosin Related Kinase B (TrkB) Signaling Pathway. J Nat Prod. 2022 03 25; 85(3):562-571. Mehrotra S, Pierce ML, Cao Z, Jabba SV, Gerwick WH, Murray TF. PMID: 35239341; PMCID: PMC9245549.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    31. Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi. J Med Chem. 2022 03 10; 65(5):4255-4269. Barbosa Da Silva E, Sharma V, Hernandez-Alvarez L, Tang AH, Stoye A, O'Donoghue AJ, Gerwick WH, Payne RJ, McKerrow JH, Podust LM. PMID: 35188371.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    32. Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance. Commun Biol. 2022 02 11; 5(1):128. Ottilie S, Luth MR, Hellemann E, Goldgof GM, Vigil E, Kumar P, Cheung AL, Song M, Godinez-Macias KP, Carolino K, Yang J, Lopez G, Abraham M, Tarsio M, LeBlanc E, Whitesell L, Schenken J, Gunawan F, Patel R, Smith J, Love MS, Williams RM, McNamara CW, Gerwick WH, Ideker T, Suzuki Y, Wirth DF, Lukens AK, Kane PM, Cowen LE, Durrant JD, Winzeler EA. PMID: 35149760; PMCID: PMC8837787.
      View in: PubMed   Mentions: 6  Translation:Animals
    33. Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B. Biochemistry. 2022 02 15; 61(4):228-238. Yoon MC, Christy MP, Phan VV, Gerwick WH, Hook G, O'Donoghue AJ, Hook V. PMID: 35119840; PMCID: PMC9096814.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    34. SMART-Miner: A convolutional neural network-based metabolite identification from 1 H-13 C HSQC spectra. Magn Reson Chem. 2022 Nov; 60(11):1070-1075. Kim HW, Zhang C, Cottrell GW, Gerwick WH. PMID: 34928526.
      View in: PubMed   Mentions: 7     Fields:    
    35. Luquilloamides, Cytotoxic Lipopeptides from a Puerto Rican Collection of the Filamentous Marine Cyanobacterium Oscillatoria sp. J Org Chem. 2022 01 21; 87(2):1043-1055. Kim GJ, Mascuch SJ, Mevers E, Boudreau PD, Gerwick WH, Choi H. PMID: 34967649.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    36. Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. J Med Chem. 2022 02 24; 65(4):2956-2970. Ashhurst AS, Tang AH, Fajtová P, Yoon MC, Aggarwal A, Bedding MJ, Stoye A, Beretta L, Pwee D, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CT, Larance M, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. PMID: 34730959; PMCID: PMC8577376.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    37. NPClassifier: A Deep Neural Network-Based Structural Classification Tool for Natural Products. J Nat Prod. 2021 11 26; 84(11):2795-2807. Kim HW, Wang M, Leber CA, Nothias LF, Reher R, Kang KB, van der Hooft JJJ, Dorrestein PC, Gerwick WH, Cottrell GW. PMID: 34662515; PMCID: PMC8631337.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    38. First Total Synthesis and Structure-Activity Relationship of Iheyamide A, an Antitrypanosomal Linear Peptide Isolated from a Dapis sp. Marine Cyanobacterium. J Nat Prod. 2021 09 24; 84(9):2587-2593. Iwasaki A, Teranuma K, Kurisawa N, Rahmawati Y, Jeelani G, Nozaki T, Gerwick WH, Suenaga K. PMID: 34488344.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    39. Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions. ACS Chem Biol. 2021 09 17; 16(9):1628-1643. Yoon MC, Solania A, Jiang Z, Christy MP, Podvin S, Mosier C, Lietz CB, Ito G, Gerwick WH, Wolan DW, Hook G, O'Donoghue AJ, Hook V. PMID: 34416110; PMCID: PMC9104225.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    40. SIRT1 Activation Enhancing 8,3'-Neolignans from the Twigs of Corylopsis coreana Uyeki. Plants (Basel). 2021 Aug 16; 10(8). Kim HW, Jeon JB, Zhang M, Cho HM, Ryu B, Lee BW, Gerwick WH, Oh WK. PMID: 34451729; PMCID: PMC8398912.
      View in: PubMed   Mentions:
    41. Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium. J Nat Prod. 2021 08 27; 84(8):2081-2093. Demirkiran O, Almaliti J, Leão T, Navarro G, Byrum T, Valeriote FA, Gerwick L, Gerwick WH. PMID: 34269583.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    42. Cyanobacteria-shrimp colonies in the Mariana Islands. Aquat Ecol. 2021 Jun; 55(2):453-465. Leber CA, Reyes AJ, Biggs JS, Gerwick WH. PMID: 34177357; PMCID: PMC8223766.
      View in: PubMed   Mentions:
    43. Total Synthesis of Laucysteinamide A, a Monomeric Congener of Somocystinamide A. J Nat Prod. 2021 03 26; 84(3):865-870. Taylor KS, Zhang C, Glukhov E, Gerwick WH, Suyama TL. PMID: 33635664.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    44. Kalkitoxin Reduces Osteoclast Formation and Resorption and Protects against Inflammatory Bone Loss. Int J Mol Sci. 2021 Feb 25; 22(5). Li L, Yang M, Shrestha SK, Kim H, Gerwick WH, Soh Y. PMID: 33669069; PMCID: PMC7956546.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    45. A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria. Mar Drugs. 2021 Jan 06; 19(1). Leão T, Wang M, Moss N, da Silva R, Sanders J, Nurk S, Gurevich A, Humphrey G, Reher R, Zhu Q, Belda-Ferre P, Glukhov E, Whitner S, Alexander KL, Rex R, Pevzner P, Dorrestein PC, Knight R, Bandeira N, Gerwick WH, Gerwick L. PMID: 33418911; PMCID: PMC7825088.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    46. Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L. bioRxiv. 2020 Dec 24. Ashhurst AS, Tang AH, Fajtová P, Yoon M, Aggarwal A, Stoye A, Larance M, Beretta L, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CK, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. PMID: 33398273; PMCID: PMC7781308.
      View in: PubMed   Mentions: 3  
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    301. Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly. J Nat Prod. 2002 Jun; 65(6):866-71. Marquez BL, Watts KS, Yokochi A, Roberts MA, Verdier-Pinard P, Jimenez JI, Hamel E, Scheuer PJ, Gerwick WH. PMID: 12088429.
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    302. Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii. J Nat Prod. 2002 Jun; 65(6):925-8. Tan LT, Márquez BL, Gerwick WH. PMID: 12088441.
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    303. Somocystinamide A, a novel cytotoxic disulfide dimer from a Fijian marine cyanobacterial mixed assemblage. Org Lett. 2002 Apr 04; 4(7):1095-8. Nogle LM, Gerwick WH. PMID: 11922791.
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    304. Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases. Inflamm Res. 2002 Feb; 51(2):112-4. Stevenson CS, Capper EA, Roshak AK, Marquez B, Grace K, Gerwick WH, Jacobs RS, Marshall LA. PMID: 11926312.
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    305. Isolation of four new cyclic depsipeptides, antanapeptins A-D, and dolastatin 16 from a Madagascan collection of Lyngbya majuscula. J Nat Prod. 2002 Jan; 65(1):21-4. Nogle LM, Gerwick WH. PMID: 11809058.
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    306. Vidalenolone, a novel phenolic metabolite from the tropical red alga Vidalia sp. J Nat Prod. 2002 Jan; 65(1):51-3. Yoo HD, Ketchum SO, France D, Bair K, Gerwick WH. PMID: 11809064.
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    307. Synthesis of the marine natural product barbamide. Chem Commun (Camb). 2001 Oct 07; (19):1934-5. Nguyen VA, Willis CL, Gerwick WH. PMID: 12240226.
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    308. Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7599-604. Li WI, Berman FW, Okino T, Yokokawa F, Shioiri T, Gerwick WH, Murray TF. PMID: 11416227; PMCID: PMC34714.
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    309. Somamides A and B, two new depsipeptide analogues of dolastatin 13 from a Fijian cyanobacterial assemblage of Lyngbya majuscula and Schizothrix species. J Nat Prod. 2001 Jun; 64(6):716-9. Nogle LM, Williamson RT, Gerwick WH. PMID: 11421730.
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    310. Nitrogen-containing metabolites from marine cyanobacteria. Alkaloids Chem Biol. 2001; 57:75-184. Gerwick WH, Tan LT, Sitachitta N. PMID: 11705123.
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    311. Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 2000 Oct; 63(10):1440-3. Milligan KE, Marquez BL, Williamson RT, Gerwick WH. PMID: 11076574.
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    312. Hermitamides A and B, toxic malyngamide-type natural products from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 2000 Jul; 63(7):952-5. Tan LT, Okino T, Gerwick WH. PMID: 10924172.
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    313. Two new malyngamides from a Madagascan Lyngbya majuscula. J Nat Prod. 2000 Jul; 63(7):965-8. Milligan KE, Márquez B, Williamson RT, Davies-Coleman M, Gerwick WH. PMID: 10924175.
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    314. Application of the BIRD sandwich for the rapid and accurate determination of (1)H-(1)H NMR coupling constants in higher order spin systems. J Nat Prod. 2000 Jun; 63(6):876-8. Williamson RT, Carney JR, Gerwick WH. PMID: 10869227.
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    315. New diffusion-edited NMR experiments to expedite the dereplication of known compounds from natural product mixtures. Org Lett. 2000 Feb 10; 2(3):289-92. Williamson RT, Chapin EL, Carr AW, Gilbert JR, Graupner PR, Lewer P, McKamey P, Carney JR, Gerwick WH. PMID: 10814304.
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    316. Yanucamides A and B, two new depsipeptides from an assemblage of the marine cyanobacteria Lyngbya majuscula and Schizothrix species. J Nat Prod. 2000 Feb; 63(2):197-200. Sitachitta N, Williamson RT, Gerwick WH. PMID: 10691708.
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    317. cis,cis- and trans,trans-ceratospongamide, new bioactive cyclic heptapeptides from the Indonesian red alga Ceratodictyon spongiosum and symbiotic sponge Sigmadocia symbiotica. J Org Chem. 2000 Jan 28; 65(2):419-25. Tan LT, Williamson RT, Gerwick WH, Watts KS, McGough K, Jacobs R. PMID: 10813950.
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    318. 5-Lipoxygenase-derived oxylipins from the red alga Rhodymenia pertusa. Phytochemistry. 2000 Jan; 53(1):129-33. Jiang ZD, Ketchum SO, Gerwick WH. PMID: 10656420.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    319. Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity. Toxicon. 1999 Nov; 37(11):1645-8. Berman FW, Gerwick WH, Murray TF. PMID: 10482399.
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    320. Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin. Arch Biochem Biophys. 1999 Oct 01; 370(1):51-8. Verdier-Pinard P, Sitachitta N, Rossi JV, Sackett DL, Gerwick WH, Hamel E. PMID: 10496976.
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    321. Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 1999 Sep; 62(9):1333-5. Singh IP, Milligan KE, Gerwick WH. PMID: 10514329.
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    322. Biogenesis and biological function of marine algal oxylipins. Adv Exp Med Biol. 1999; 447:211-8. Gerwick WH, Roberts MA, Vulpanovici A, Ballantine DL. PMID: 10086197.
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    323. Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula. Phytochemistry. 1998 Dec; 49(8):2387-9. Márquez B, Verdier-Pinard P, Hamel E, Gerwick WH. PMID: 9887531.
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    324. Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem Biophys Res Commun. 1998 Jul 30; 248(3):515-22. Bisogno T, Melck D, De Petrocellis L, Gretskaya NM, Bezuglov VV, Sitachitta N, Gerwick WH, Di Marzo V. PMID: 9703957.
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    325. Kalkipyrone, a toxic gamma-pyrone from an assemblage of the marine cyanobacteria Lyngbya majuscula and Tolypothrix sp. J Nat Prod. 1998 May; 61(5):677-80. Graber MA, Gerwick WH. PMID: 9599278.
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    326. Grenadadiene and grenadamide, cyclopropyl-containing fatty acid metabolites from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 1998 May; 61(5):681-4. Sitachitta N, Gerwick WH. PMID: 9599279.
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    327. Carmabins A and B, new lipopeptides from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod. 1998 Apr; 61(4):529-33. Hooper GJ, Orjala J, Schatzman RC, Gerwick WH. PMID: 9584405.
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    328. Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells. Mol Pharmacol. 1998 Jan; 53(1):62-76. Verdier-Pinard P, Lai JY, Yoo HD, Yu J, Marquez B, Nagle DG, Nambu M, White JD, Falck JR, Gerwick WH, Day BW, Hamel E. PMID: 9443933.
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    329. Two quinoline alkaloids from the Caribbean cyanobacterium Lyngbya majuscula. Phytochemistry. 1997 Jul; 45(5):1087-90. Orjala J, Gerwick WH. PMID: 9214778.
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    330. Characterization of the substrate binding site of polyenoic fatty acid isomerase, a novel enzyme from the marine alga Ptilota filicina. Biochemistry. 1997 Mar 11; 36(10):2985-92. Wise ML, Rossi J, Gerwick WH. PMID: 9062129.
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    331. Novel oxylipins from the temperate red alga Polyneura latissima: evidence for an arachidonate 9(S)-lipoxygenase. Lipids. 1997 Mar; 32(3):231-5. Jiang ZD, Gerwick WH. PMID: 9076659.
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    332. Biosynthesis and cannabinoid receptor affinity of the novel eicosanoid, conjugated triene anandamide. Adv Exp Med Biol. 1997; 407:329-34. Gerwick WH, Wise ML, Soderstrom K, Murray TF. PMID: 9321972.
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    333. Discovery of novel cannabinoid receptor ligands from diverse marine organisms. Adv Exp Med Biol. 1997; 433:73-7. Soderstrom K, Murray TF, Yoo HD, Ketchum S, Milligan K, Gerwick W, Ortega MJ, Salva J. PMID: 9561107.
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    334. Epoxy allylic carbocations as conceptual intermediates in the biogenesis of diverse marine oxylipins. Lipids. 1996 Dec; 31(12):1215-31. Gerwick WH. PMID: 8972454.
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    335. Barbamide, a chlorinated metabolite with molluscicidal activity from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod. 1996 Apr; 59(4):427-30. Orjala J, Gerwick WH. PMID: 8699186.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    336. Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid. Experientia. 1996 Jan 16; 52(1):88-92. Wise ML, Soderstrom K, Murray TF, Gerwick WH. PMID: 8575565.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    337. Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues. Mol Pharmacol. 1995 Sep; 48(3):523-31. Blokhin AV, Yoo HD, Geralds RS, Nagle DG, Gerwick WH, Hamel E. PMID: 7565634.
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    338. Structure and biosynthesis of novel conjugated polyene fatty acids from the marine green alga Anadyomene stellata. Lipids. 1995 Jul; 30(7):583-9. Mikhailova MV, Bemis DL, Wise ML, Gerwick WH, Norris JN, Jacobs RS. PMID: 7564911.
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    339. Malyngamide H, an ichthyotoxic amide possessing a new carbon skeleton from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod. 1995 May; 58(5):764-8. Orjala J, Nagle D, Gerwick WH. PMID: 7623050.
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    340. Isolation of a cyclic carbonate, a gamma-butyrolactone, and a new indole derivative from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 1995 Apr; 58(4):586-9. Todd JS, Gerwick WH. PMID: 7623035.
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    341. Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina. Biochemistry. 1994 Dec 27; 33(51):15223-32. Wise ML, Hamberg M, Gerwick WH. PMID: 7803384.
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    342. Absolute stereochemistry of neohalicholactone from the brown alga Laminaria sinclairii. J Nat Prod. 1994 Dec; 57(12):1717-9. Proteau PJ, Rossi JV, Gerwick WH. PMID: 7714540.
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    343. Isorawsonol and related IMP dehydrogenase inhibitors from the tropical green alga Avrainvillea rawsonii. J Nat Prod. 1994 Jul; 57(7):947-52. Chen JL, Gerwick WH, Schatzman R, Laney M. PMID: 7964790.
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    344. Structure of malhamensilipin A, an inhibitor of protein tyrosine kinase, from the cultured chrysophyte Poterioochromonas malhamensis. J Nat Prod. 1994 Apr; 57(4):524-7. Chen JL, Proteau PJ, Roberts MA, Gerwick WH, Slate DL, Lee RH. PMID: 8021653.
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    345. Structure and biosynthesis of marine algal oxylipins. Biochim Biophys Acta. 1994 Mar 24; 1211(3):243-55. Gerwick WH. PMID: 8130256.
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    346. The absolute configuration of ecklonialactones A, B, and E, novel oxylipins from brown algae of the genera Ecklonia and Egregia. J Nat Prod. 1994 Jan; 57(1):171-4. Todd JS, Proteau PJ, Gerwick WH. PMID: 8158161.
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    347. The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria. Experientia. 1993 Sep 15; 49(9):825-9. Proteau PJ, Gerwick WH, Garcia-Pichel F, Castenholz R. PMID: 8405307.
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    348. Divinyl ethers and hydroxy fatty acids from three species of Laminaria (brown algae). Lipids. 1993 Sep; 28(9):783-7. Proteau PJ, Gerwick WH. PMID: 8231653.
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    349. Biosynthesis of vicinal dihydroxy fatty acids in the red alga Gracilariopsis lemaneiformis: identification of a sodium-dependent 12-lipoxygenase and a hydroperoxide isomerase. Arch Biochem Biophys. 1993 Aug 15; 305(1):115-22. Hamberg M, Gerwick WH. PMID: 8342944.
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    350. Unprecedented oxylipins from the marine green alga Acrosiphonia coalita. J Nat Prod. 1993 Feb; 56(2):245-59. Bernart MW, Whatley GG, Gerwick WH. PMID: 8463797.
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    351. New glycosphingolipids from the marine sponge Halichondria panicea. J Nat Prod. 1992 Jul; 55(7):1013-7. Nagle DG, McClatchey WC, Gerwick WH. PMID: 1402953.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    352. Cell-free biosynthesis and source of hydroxyl groups in (12R,13S)-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid, a novel eicosanoid from the marine alga Gracilariopsis lemaneiformis. J Nat Prod. 1991 Nov-Dec; 54(6):1619-24. Moghaddam MF, Gerwick WH. PMID: 1667411.
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    353. An aldehyde-containing galactolipid from the red alga Gracilariopsis lemaneiformis. Lipids. 1991 Nov; 26(11):960-3. Jiang ZD, Gerwick WH. PMID: 1805099.
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    354. Oxylipin metabolism in the red alga Gracilariopsis lemaneiformis: mechanism of formation of vicinal dihydroxy fatty acids. Arch Biochem Biophys. 1991 Nov 01; 290(2):436-44. Gerwick WH, Moghaddam M, Hamberg M. PMID: 1929410.
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    355. Novel pyrroles from the Oregon red alga Gracilariopsis lemaneiformis. J Nat Prod. 1991 Mar-Apr; 54(2):403-7. Jiang ZD, Gerwick WH. PMID: 1919587.
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    356. Discovery of the mammalian insulin release modulator, hepoxilin B3, from the tropical red algae Platysiphonia miniata and Cottoniella filamentosa. J Biol Chem. 1990 Apr 15; 265(11):6126-30. Moghaddam MF, Gerwick WH, Ballantine DL. PMID: 2180942.
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    357. Three new and bioactive icosanoids from the temperate red marine alga Farlowia mollis. Lipids. 1989 Apr; 24(4):256-60. Solem ML, Jiang ZD, Gerwick WH. PMID: 2547132.
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    358. 6-Desmethoxyhormothamnione, a new cytotoxic styrylchromone from the marine cryptophyte Chrysophaeum taylori. J Nat Prod. 1989 Mar-Apr; 52(2):252-6. Gerwick WH. PMID: 2746254.
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    359. Novel cytotoxic peptides from the tropical marine cyanobacterium Hormothamnion enteromorphoides. 1. Discovery, isolation and initial chemical and biological characterization of the hormothamnins from wild and cultured material. Experientia. 1989 Feb 15; 45(2):115-21. Gerwick WH, Mrozek C, Moghaddam MF, Agarwal SK. PMID: 2493387.
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    360. Discovery of 12-(S)-hydroxy-5,8,10,14-icosatetraenoic acid [12-(S)-HETE] in the tropical red alga Platysiphonia miniata. Prostaglandins. 1989 Feb; 37(2):303-8. Moghaddam MF, Gerwick WH, Ballantine DL. PMID: 2727309.
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    361. Aplysia sea hare assimilation of secondary metabolites from brown seaweed,Stypopodium zonale. J Chem Ecol. 1989 Feb; 15(2):677-83. Gerwick WH, Whatley G. PMID: 24271808.
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    362. Precipitate analysis from an indwelling total parenteral nutrition catheter. JPEN J Parenter Enteral Nutr. 1988 Jan-Feb; 12(1):88-92. Stennett DJ, Gerwick WH, Egging PK, Christensen JM. PMID: 3125364.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    363. 5'-Hydroxyisoavrainvilleol, a new diphenylmethane derivative from the tropical green alga Avrainvillea nigricans. J Nat Prod. 1987 May-Jun; 50(3):368-74. Colon M, Guevara P, Gerwick WH, Ballantine D. PMID: 3668556.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    364. Two new icosapentaenoic acids from the temperate red seaweed Ptilota filicina J. Agardh. Lipids. 1987 Mar; 22(3):190-4. Lopez A, Gerwick WH. PMID: 3033420.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
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