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    William Gerwick

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentSchool of Pharmacy and Pharmaceutical Science
    Address9500 Gilman Drive #0212
    CA La Jolla 92093
    Phone858-534-0578
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      Collapse Research 
      Collapse Research Activities and Funding
      Development of an efficient cyanobacterial platform for heterologous expression and biosynthetic interrogations of natural products.
      NIH/NIGMS R01GM118815Jan 12, 2017 - Dec 31, 2020
      Role: Principal Investigator
      Development of Gallinamide A-Inspired Agents for the Treatment of Chagas? Disease
      NIH/NIAID R21AI127505Dec 7, 2016 - Nov 30, 2018
      Role: Principal Investigator
      Tools for rapid and accurate structure elucidation of natural products
      NIH/NIGMS R01GM107550Sep 5, 2013 - Apr 30, 2021
      Role: Principal Investigator
      Huntington's Disease Natural Product Drug Discovery
      NIH/NIA R21AG038772Sep 1, 2011 - Aug 31, 2014
      Role: Principal Investigator
      Biosynthetic Analysis of Marine Cyanobacterial Pathways
      NIH/NCI R01CA108874Jul 1, 2004 - May 31, 2016
      Role: Principal Investigator
      ICBG: "Training, Conservation and Drug Discovery using Panamanian Microorganisms
      NIH/FIC U01TW006634Sep 27, 2003 - May 31, 2014
      Role: Principal Investigator
      Training Program in Marine Biotechnology
      NIH/NIGMS T32GM067550Jul 1, 2003 - Jun 30, 2020
      Role: Principal Investigator
      US-Japan Seminar on Marine Bioorganic Chemistry
      NIH/NCI R13CA102377Jun 1, 2003 - May 31, 2004
      Role: Principal Investigator
      Neurotoxins from Marine Algae and Cyanobacteria
      NIH/NINDS R01NS053398Jul 1, 2001 - Jun 30, 2016
      Role: Principal Investigator
      Neurotoxins from Marine Algae and Cyanobacteria
      NIH/NIGMS R01GM063554Jul 1, 2001 - Jun 30, 2005
      Role: Principal Investigator
      EICOSANOID BIOSYNTHESIS IN MARINE PLANTS
      NIH/FIC F06TW001616Jun 21, 1991
      Role: Principal Investigator
      Targeted Discovery of Marine-derived Anticancer Leads
      NIH U19CA052955Sep 1, 1990 - Apr 30, 2012
      Role: Co-Investigator
      SMALL INSTRUMENTATION PROGRAM
      NIH/NIEHS S15ES005267Aug 15, 1989 - Jul 31, 1990
      Role: Principal Investigator
      ANTINEOPLASTIC AGENTS FROM BLUE GREEN ALGAE
      NIH/NCI R23CA042850Jul 1, 1986 - Jun 30, 1990
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, Gerwick W. Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. J Nat Prod. 2017 Aug 25; 80(8):2328-2334. PMID: 28783331.
        View in: PubMed
      2. LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, Gerwick W, Ottilie S. Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. J Med Chem. 2017 Aug 10; 60(15):6721-6732. PMID: 28696697.
        View in: PubMed
      3. Luzzatto-Knaan T, Garg N, Wang M, Glukhov E, Peng Y, Ackermann G, Amir A, Duggan BM, Ryazanov S, Gerwick L, Knight R, Alexandrov T, Bandeira N, Gerwick W, Dorrestein PC. Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. Elife. 2017 May 11; 6. PMID: 28492366.
        View in: PubMed
      4. Kinnel RB, Esquenazi E, Leao T, Moss N, Mevers E, Pereira AR, Monroe EA, Korobeynikov A, Murray TF, Sherman D, Gerwick L, Dorrestein PC, Gerwick W. A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. J Nat Prod. 2017 May 26; 80(5):1514-1521. PMID: 28448144.
        View in: PubMed
      5. Zhang C, Naman CB, Engene N, Gerwick W. Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata. Mar Drugs. 2017 Apr 14; 15(4). PMID: 28420100.
        View in: PubMed
      6. Leao T, Castelão G, Korobeynikov A, Monroe EA, Podell S, Glukhov E, Allen EE, Gerwick W, Gerwick L. Comparative genomics uncovers the prolific and distinctive metabolic potential of the cyanobacterial genus Moorea. Proc Natl Acad Sci U S A. 2017 Mar 21; 114(12):3198-3203. PMID: 28265051.
        View in: PubMed
      7. Cummings SL, Barbé D, Leao TF, Korobeynikov A, Engene N, Glukhov E, Gerwick W, Gerwick L. A novel uncultured heterotrophic bacterial associate of the cyanobacterium Moorea producens JHB. BMC Microbiol. 2016 Aug 30; 16(1):198. PMID: 27577966; PMCID: PMC5006271.
        View in: PubMed, PubMed Central
      8. Maloney FP, Gerwick L, Gerwick W, Sherman DH, Smith JL. Anatomy of the ß-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proc Natl Acad Sci U S A. 2016 Sep 13; 113(37):10316-21. PMID: 27573844; PMCID: PMC5027445 [Available on 03/13/17].
        View in: PubMed, PubMed Central
      9. Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick W, Moore BS, Dorrestein PC, Bandeira N. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 Aug 09; 34(8):828-837. PMID: 27504778.
        View in: PubMed
      10. Kunz HH, Park J, Mevers E, García AV, Highhouse S, Gerwick W, Parker JE, Schroeder JI. Small Molecule DFPM Derivative-Activated Plant Resistance Protein Signaling in Roots Is Unaffected by EDS1 Subcellular Targeting Signal and Chemical Genetic Isolation of victr R-Protein Mutants. PLoS One. 2016; 11(5):e0155937. PMID: 27219122; PMCID: PMC4878808.
        View in: PubMed, PubMed Central
      11. Kleigrewe K, Gerwick L, Sherman DH, Gerwick W. Unique marine derived cyanobacterial biosynthetic genes for chemical diversity. Nat Prod Rep. 2016 Feb; 33(2):348-64. PMID: 26758451.
        View in: PubMed
      12. Bertin MJ, Vulpanovici A, Monroe EA, Korobeynikov A, Sherman DH, Gerwick L, Gerwick W. The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide. Chembiochem. 2016 Jan; 17(2):164-73. PMID: 26769357; PMCID: PMC4878910 [Available on 01/01/17].
        View in: PubMed, PubMed Central
      13. Bertin MJ, Demirkiran O, Navarro G, Moss NA, Lee J, Goldgof GM, Vigil E, Winzeler EA, Valeriote FA, Gerwick W. Kalkipyrone B, a marine cyanobacterial ?-pyrone possessing cytotoxic and anti-fungal activities. Phytochemistry. 2016 Feb; 122:113-118. PMID: 26632528; PMCID: PMC4724546 [Available on 02/01/17].
        View in: PubMed, PubMed Central
      14. Teta R, Della Sala G, Glukhov E, Gerwick L, Gerwick W, Mangoni A, Costantino V. Combined LC-MS/MS and Molecular Networking Approach Reveals New Cyanotoxins from the 2014 Cyanobacterial Bloom in Green Lake, Seattle. Environ Sci Technol. 2015 Dec 15; 49(24):14301-10. PMID: 26567695; PMCID: PMC4851459 [Available on 12/15/16].
        View in: PubMed, PubMed Central
      15. Moss NA, Bertin MJ, Kleigrewe K, Leão TF, Gerwick L, Gerwick W. Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery. J Ind Microbiol Biotechnol. 2016 Mar; 43(2-3):313-24. PMID: 26578313.
        View in: PubMed
      16. Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick W, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO. Minimum Information about a Biosynthetic Gene cluster. Nat Chem Biol. 2015 Sep; 11(9):625-31. PMID: 26284661.
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      17. Shao CL, Linington RG, Balunas MJ, Centeno A, Boudreau P, Zhang C, Engene N, Spadafora C, Mutka TS, Kyle DE, Gerwick L, Wang CY, Gerwick W. Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. J Org Chem. 2015 Aug 21; 80(16):7849-55. PMID: 26222145.
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      18. Leão PN, Nakamura H, Costa M, Pereira AR, Martins R, Vasconcelos V, Gerwick W, Balskus EP. Biosynthesis-assisted structural elucidation of the bartolosides, chlorinated aromatic glycolipids from cyanobacteria. Angew Chem Int Ed Engl. 2015 Sep 14; 54(38):11063-7. PMID: 26235728.
        View in: PubMed
      19. Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick W. Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows. PLoS One. 2015; 10(7):e0133297. PMID: 26222584; PMCID: PMC4519256.
        View in: PubMed, PubMed Central
      20. Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, Monroe EA, Duggan BM, Di Marzo V, Sherman DH, Dorrestein PC, Gerwick L, Gerwick W. Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. J Nat Prod. 2015 Jul 24; 78(7):1671-82. PMID: 26149623; PMCID: PMC4681511.
        View in: PubMed, PubMed Central
      21. Moore BS, Gerwick W. Special issue in honor of William Fenical, a pioneer in marine natural products discovery and drug development. J Nat Prod. 2015 Mar 27; 78(3):347-8. PMID: 25814030.
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      22. Morgan JB, Liu Y, Coothankandaswamy V, Mahdi F, Jekabsons MB, Gerwick W, Valeriote FA, Zhou YD, Nagle DG. Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells. Mar Drugs. 2015 Mar 20; 13(3):1552-68. PMID: 25803180; PMCID: PMC4377999.
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      23. Rho JR, Subramaniam G, Choi H, Kim EH, Ng SP, Yoganathan K, Ng S, Buss AD, Butler MS, Gerwick W. Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp. Org Lett. 2015 Mar 20; 17(6):1377-80. PMID: 25723256.
        View in: PubMed
      24. Bertin MJ, Schwartz SL, Lee J, Korobeynikov A, Dorrestein PC, Gerwick L, Gerwick W. Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta. J Nat Prod. 2015 Mar 27; 78(3):493-9. PMID: 25668560.
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      25. Cao Z, Li X, Zou X, Greenwood M, Gerwick W, Murray TF. Involvement of JNK and caspase activation in hoiamide A-induced neurotoxicity in neocortical neurons. Mar Drugs. 2015 Feb 10; 13(2):903-19. PMID: 25675001; PMCID: PMC4344608.
        View in: PubMed, PubMed Central
      26. Vining OB, Medina RA, Mitchell EA, Videau P, Li D, Serrill JD, Kelly JX, Gerwick W, Proteau PJ, Ishmael JE, McPhail KL. Depsipeptide companeramides from a Panamanian marine cyanobacterium associated with the coibamide producer. J Nat Prod. 2015 Mar 27; 78(3):413-20. PMID: 25562664; PMCID: PMC4380200.
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      27. Mehrotra S, Duggan BM, Tello-Aburto R, Newar TD, Gerwick W, Murray TF, Maio WA. Detailed analysis of (-)-palmyrolide a and some synthetic derivatives as voltage-gated sodium channel antagonists. J Nat Prod. 2014 Nov 26; 77(11):2553-60. PMID: 25343669; PMCID: PMC4251536.
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      28. Vogel CV, Pietraszkiewicz H, Sabry OM, Gerwick W, Valeriote FA, Vanderwal CD. Enantioselective divergent syntheses of several polyhalogenated Plocamium monoterpenes and evaluation of their selectivity for solid tumors. Angew Chem Int Ed Engl. 2014 Nov 03; 53(45):12205-9. PMID: 25220828; PMCID: PMC4219742.
        View in: PubMed, PubMed Central
      29. Mevers E, Matainaho T, Allara' M, Di Marzo V, Gerwick W. Mooreamide A: a cannabinomimetic lipid from the marine cyanobacterium Moorea bouillonii. Lipids. 2014 Nov; 49(11):1127-32. PMID: 25204580.
        View in: PubMed
      30. Moree WJ, McConnell OJ, Nguyen DD, Sanchez LM, Yang YL, Zhao X, Liu WT, Boudreau PD, Srinivasan J, Atencio L, Ballesteros J, Gavilán RG, Torres-Mendoza D, Guzmán HM, Gerwick W, Gutiérrez M, Dorrestein PC. Microbiota of healthy corals are active against fungi in a light-dependent manner. ACS Chem Biol. 2014 Oct 17; 9(10):2300-8. PMID: 25058318; PMCID: PMC4201335.
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      31. Trivella DB, Pereira AR, Stein ML, Kasai Y, Byrum T, Valeriote FA, Tantillo DJ, Groll M, Gerwick W, Moore BS. Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chem Biol. 2014 Jun 19; 21(6):782-91. PMID: 24930969; PMCID: PMC4103027.
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      32. Xu DX, Sun P, Kurtán T, Mándi A, Tang H, Liu B, Gerwick W, Wang ZW, Zhang W. Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka. J Nat Prod. 2014 May 23; 77(5):1179-84. PMID: 24749951.
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      33. Gong J, Sun P, Jiang N, Riccio R, Lauro G, Bifulco G, Li TJ, Gerwick W, Zhang W. New steroids with a rearranged skeleton as (h)P300 inhibitors from the sponge Theonella swinhoei. Org Lett. 2014 Apr 18; 16(8):2224-7. PMID: 24694058.
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      34. Almeida C, Ortega H, Higginbotham S, Spadafora C, Arnold AE, Coley PD, Kursar TA, Gerwick W, Cubilla-Rios L. Chemical and bioactive natural products from Microthyriaceae sp., an endophytic fungus from a tropical grass. Lett Appl Microbiol. 2014 Jul; 59(1):58-64. PMID: 24612068.
        View in: PubMed
      35. Mevers E, Haeckl FP, Boudreau PD, Byrum T, Dorrestein PC, Valeriote FA, Gerwick W. Lipopeptides from the tropical marine cyanobacterium Symploca sp. J Nat Prod. 2014 Apr 25; 77(4):969-75. PMID: 24588245; PMCID: PMC4002153.
        View in: PubMed, PubMed Central
      36. Zhou W, Li J, E HC, Liu BS, Tang H, Gerwick W, Hua HM, Zhang W. Briarane diterpenes from the South China Sea gorgonian coral, Junceella gemmacea. Mar Drugs. 2014 Jan 27; 12(2):589-600. PMID: 24473165; PMCID: PMC3944505.
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      37. Coates RC, Podell S, Korobeynikov A, Lapidus A, Pevzner P, Sherman DH, Allen EE, Gerwick L, Gerwick W. Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. PLoS One. 2014; 9(1):e85140. PMID: 24475038; PMCID: PMC3903477.
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      38. Carneiro VM, Avila CM, Balunas MJ, Gerwick W, Pilli RA. Coibacins A and B: total synthesis and stereochemical revision. J Org Chem. 2014 Jan 17; 79(2):630-42. PMID: 24359482; PMCID: PMC3962765.
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      39. Miller B, Friedman AJ, Choi H, Hogan J, McCammon JA, Hook V, Gerwick W. The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. J Nat Prod. 2014 Jan 24; 77(1):92-9. PMID: 24364476; PMCID: PMC3932306.
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      40. Winnikoff JR, Glukhov E, Watrous J, Dorrestein PC, Gerwick W. Quantitative molecular networking to profile marine cyanobacterial metabolomes. J Antibiot (Tokyo). 2014 Jan; 67(1):105-12. PMID: 24281659.
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      41. Trentacoste EM, Shrestha RP, Smith SR, Glé C, Hartmann AC, Hildebrand M, Gerwick W. Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19748-53. PMID: 24248374; PMCID: PMC3856844.
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      42. Whicher JR, Smaga SS, Hansen DA, Brown WC, Gerwick W, Sherman DH, Smith JL. Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis. Chem Biol. 2013 Nov 21; 20(11):1340-51. PMID: 24183970; PMCID: PMC3870462.
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      43. Pavlik CM, Wong CY, Ononye S, Lopez DD, Engene N, McPhail KL, Gerwick W, Balunas MJ. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22; 76(11):2026-33. PMID: 24164245; PMCID: PMC3879121.
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      44. Liu WT, Lamsa A, Wong WR, Boudreau PD, Kersten R, Peng Y, Moree WJ, Duggan BM, Moore BS, Gerwick W, Linington RG, Pogliano K, Dorrestein PC. MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. J Antibiot (Tokyo). 2014 Jan; 67(1):99-104. PMID: 24149839; PMCID: PMC3919142.
        View in: PubMed, PubMed Central
      45. Mevers E, Byrum T, Gerwick W. Parguerene and precarriebowmide, two classes of lipopeptides from the marine cyanobacterium Moorea producens. J Nat Prod. 2013 Sep 27; 76(9):1810-4. PMID: 24044577; PMCID: PMC3962764.
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      46. Yang JY, Sanchez LM, Rath CM, Liu X, Boudreau PD, Bruns N, Glukhov E, Wodtke A, de Felicio R, Fenner A, Wong WR, Linington RG, Zhang L, Debonsi HM, Gerwick W, Dorrestein PC. Molecular networking as a dereplication strategy. J Nat Prod. 2013 Sep 27; 76(9):1686-99. PMID: 24025162; PMCID: PMC3936340.
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      47. Tan LT, Okino T, Gerwick W. Bouillonamide: a mixed polyketide-peptide cytotoxin from the marine cyanobacterium Moorea bouillonii. Mar Drugs. 2013 Aug 19; 11(8):3015-24. PMID: 23966034; PMCID: PMC3766879.
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      48. Leão PN, Costa M, Ramos V, Pereira AR, Fernandes VC, Domingues VF, Gerwick W, Vasconcelos VM, Martins R. Antitumor activity of hierridin B, a cyanobacterial secondary metabolite found in both filamentous and unicellular marine strains. PLoS One. 2013; 8(7):e69562. PMID: 23922738; PMCID: PMC3726634.
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      49. Della Sala G, Hochmuth T, Costantino V, Teta R, Gerwick W, Gerwick L, Piel J, Mangoni A. Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts. Environ Microbiol Rep. 2013 Dec; 5(6):809-18. PMID: 24249289; PMCID: PMC3908369.
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      50. Ongley SE, Bian X, Zhang Y, Chau R, Gerwick W, Müller R, Neilan BA. High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium. ACS Chem Biol. 2013 Sep 20; 8(9):1888-93. PMID: 23751865; PMCID: PMC3880125.
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      51. Leão PN, Ramos V, Gonçalves PB, Viana F, Lage OM, Gerwick W, Vasconcelos VM. Chemoecological screening reveals high bioactivity in diverse culturable Portuguese marine cyanobacteria. Mar Drugs. 2013 Apr 22; 11(4):1316-35. PMID: 23609580; PMCID: PMC3705407.
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      52. Ortega HE, Graupner PR, Asai Y, Tendyke K, Qiu D, Shen YY, Rios N, Arnold AE, Coley PD, Kursar TA, Gerwick W, Cubilla-Rios L. Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194. J Nat Prod. 2013 Apr 26; 76(4):741-4. PMID: 23560689.
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      53. Engene N, Gunasekera SP, Gerwick W, Paul VJ. Phylogenetic inferences reveal a large extent of novel biodiversity in chemically rich tropical marine cyanobacteria. Appl Environ Microbiol. 2013 Mar; 79(6):1882-8. PMID: 23315747; PMCID: PMC3592240.
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      54. Kim EJ, Lee JH, Choi H, Pereira AR, Ban YH, Yoo YJ, Kim E, Park JW, Sherman DH, Gerwick W, Yoon YJ. Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product. Org Lett. 2012 Dec 07; 14(23):5824-7. PMID: 23148802; PMCID: PMC3536539.
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      55. George J, Baden DG, Gerwick W, Murray TF. Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19840-5. PMID: 23150561; PMCID: PMC3511701.
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      56. McCarthy JG, Eisman EB, Kulkarni S, Gerwick L, Gerwick W, Wipf P, Sherman DH, Smith JL. Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. ACS Chem Biol. 2012 Dec 21; 7(12):1994-2003. PMID: 22991895; PMCID: PMC3528841.
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      57. Boudreau PD, Byrum T, Liu WT, Dorrestein PC, Gerwick W. Viequeamide A, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium. J Nat Prod. 2012 Sep 28; 75(9):1560-70. PMID: 22924493; PMCID: PMC3521035.
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      58. Balunas MJ, Grosso MF, Villa FA, Engene N, McPhail KL, Tidgewell K, Pineda LM, Gerwick L, Spadafora C, Kyle DE, Gerwick W. Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins. Org Lett. 2012 Aug 03; 14(15):3878-81. PMID: 22794317; PMCID: PMC3449157.
        View in: PubMed, PubMed Central
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      231. Nagle DG, McClatchey WC, Gerwick W. New glycosphingolipids from the marine sponge Halichondria panicea. J Nat Prod. 1992 Jul; 55(7):1013-7. PMID: 1402953.
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      232. Jiang ZD, Gerwick W. An aldehyde-containing galactolipid from the red alga Gracilariopsis lemaneiformis. Lipids. 1991 Nov; 26(11):960-3. PMID: 1805099.
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      233. Moghaddam MF, Gerwick W. Cell-free biosynthesis and source of hydroxyl groups in (12R,13S)-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid, a novel eicosanoid from the marine alga Gracilariopsis lemaneiformis. J Nat Prod. 1991 Nov-Dec; 54(6):1619-24. PMID: 1667411.
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      234. Gerwick W, Moghaddam M, Hamberg M. Oxylipin metabolism in the red alga Gracilariopsis lemaneiformis: mechanism of formation of vicinal dihydroxy fatty acids. Arch Biochem Biophys. 1991 Nov 01; 290(2):436-44. PMID: 1929410.
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      235. Jiang ZD, Gerwick W. Novel pyrroles from the Oregon red alga Gracilariopsis lemaneiformis. J Nat Prod. 1991 Mar-Apr; 54(2):403-7. PMID: 1919587.
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      236. Moghaddam MF, Gerwick W, Ballantine DL. Discovery of the mammalian insulin release modulator, hepoxilin B3, from the tropical red algae Platysiphonia miniata and Cottoniella filamentosa. J Biol Chem. 1990 Apr 15; 265(11):6126-30. PMID: 2180942.
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      237. Solem ML, Jiang ZD, Gerwick W. Three new and bioactive icosanoids from the temperate red marine alga Farlowia mollis. Lipids. 1989 Apr; 24(4):256-60. PMID: 2547132.
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      238. Gerwick W. 6-Desmethoxyhormothamnione, a new cytotoxic styrylchromone from the marine cryptophyte Chrysophaeum taylori. J Nat Prod. 1989 Mar-Apr; 52(2):252-6. PMID: 2746254.
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      239. Gerwick W, Mrozek C, Moghaddam MF, Agarwal SK. Novel cytotoxic peptides from the tropical marine cyanobacterium Hormothamnion enteromorphoides. 1. Discovery, isolation and initial chemical and biological characterization of the hormothamnins from wild and cultured material. Experientia. 1989 Feb 15; 45(2):115-21. PMID: 2493387.
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      240. Moghaddam MF, Gerwick W, Ballantine DL. Discovery of 12-(S)-hydroxy-5,8,10,14-icosatetraenoic acid [12-(S)-HETE] in the tropical red alga Platysiphonia miniata. Prostaglandins. 1989 Feb; 37(2):303-8. PMID: 2727309.
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      241. Gerwick W, Whatley G. Aplysia sea hare assimilation of secondary metabolites from brown seaweed,Stypopodium zonale. J Chem Ecol. 1989 Feb; 15(2):677-83. PMID: 24271808.
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      242. Stennett DJ, Gerwick W, Egging PK, Christensen JM. Precipitate analysis from an indwelling total parenteral nutrition catheter. JPEN J Parenter Enteral Nutr. 1988 Jan-Feb; 12(1):88-92. PMID: 3125364.
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      243. Colon M, Guevara P, Gerwick W, Ballantine D. 5'-Hydroxyisoavrainvilleol, a new diphenylmethane derivative from the tropical green alga Avrainvillea nigricans. J Nat Prod. 1987 May-Jun; 50(3):368-74. PMID: 3668556.
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      244. Lopez A, Gerwick W. Two new icosapentaenoic acids from the temperate red seaweed Ptilota filicina J. Agardh. Lipids. 1987 Mar; 22(3):190-4. PMID: 3033420.
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