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    Webster Cavenee

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0660
    CA La Jolla 92093
    vCardDownload vCard

      Collapse Bibliographic 
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Zanca C, Villa GR, Benitez JA, Thorne AH, Koga T, D'Antonio M, Ikegami S, Ma J, Boyer AD, Banisadr A, Jameson NM, Parisian AD, Eliseeva OV, Barnabe GF, Liu F, Wu S, Yang H, Wykosky J, Frazer KA, Verkhusha VV, Isaguliants MG, Weiss WA, Gahman TC, Shiau AK, Chen CC, Mischel PS, Cavenee W, Furnari FB. Glioblastoma cellular cross-talk converges on NF-?B to attenuate EGFR inhibitor sensitivity. Genes Dev. 2017 Jul 19. PMID: 28724615.
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      2. Benitez JA, Ma J, D'Antonio M, Boyer A, Camargo MF, Zanca C, Kelly S, Khodadadi-Jamayran A, Jameson NM, Andersen M, Miletic H, Saberi S, Frazer KA, Cavenee W, Furnari FB. PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nat Commun. 2017 May 12; 8:15223. PMID: 28497778.
        View in: PubMed
      3. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee W, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. PMID: 28178237.
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      4. Kegelman TP, Wu B, Das SK, Talukdar S, Beckta JM, Hu B, Emdad L, Valerie K, Sarkar D, Furnari FB, Cavenee W, Wei J, Purves A, De SK, Pellecchia M, Fisher PB. Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin. Proc Natl Acad Sci U S A. 2017 Jan 10; 114(2):370-375. PMID: 28011764.
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      5. Chou ST, Patil R, Galstyan A, Gangalum PR, Cavenee W, Furnari FB, Ljubimov VA, Chesnokova A, Kramerov AA, Ding H, Falahatian V, Mashouf L, Fox I, Black KL, Holler E, Ljubimov AV, Ljubimova JY. Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme. J Control Release. 2016 Nov 5; 244(Pt A):14-23. PMID: 27825958.
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      6. Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, Jenkins D, Martini M, Armando AM, Quehenberger O, Cloughesy TF, Furnari FB, Cavenee W, Tontonoz P, Gahman TC, Shiau AK, Cravatt BF, Mischel PS. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. Cancer Cell. 2016 Nov 14; 30(5):683-693. PMID: 27746144.
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      7. Masui K, Shibata N, Cavenee W, Mischel PS. mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling. Bioessays. 2016 Sep; 38(9):839-44. PMID: 27427440.
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      8. Masui K, Cavenee W, Mischel PS. Cancer metabolism as a central driving force of glioma pathogenesis. Brain Tumor Pathol. 2016 Jul; 33(3):161-8. PMID: 27295313.
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      9. Wei W, Shin YS, Xue M, Matsutani T, Masui K, Yang H, Ikegami S, Gu Y, Herrmann K, Johnson D, Ding X, Hwang K, Kim J, Zhou J, Su Y, Li X, Bonetti B, Chopra R, James CD, Cavenee W, Cloughesy TF, Mischel PS, Heath JR, Gini B. Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma. Cancer Cell. 2016 Apr 11; 29(4):563-573. PMID: 27070703; PMCID: PMC4831071 [Available on 04/11/17].
      10. Masui K, Cavenee W, Mischel PS. mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment. Brain Pathol. 2015 Nov; 25(6):755-9. PMID: 26526943; PMCID: PMC4636016 [Available on 11/01/16].
      11. Liu F, Hon GC, Villa GR, Turner KM, Ikegami S, Yang H, Ye Z, Li B, Kuan S, Lee AY, Zanca C, Wei B, Lucey G, Jenkins D, Zhang W, Barr CL, Furnari FB, Cloughesy TF, Yong WH, Gahman TC, Shiau AK, Cavenee W, Ren B, Mischel PS. EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling. Mol Cell. 2015 Oct 15; 60(2):307-18. PMID: 26455392; PMCID: PMC4609298 [Available on 10/15/16].
      12. Masui K, Tanaka K, Ikegami S, Villa GR, Yang H, Yong WH, Cloughesy TF, Yamagata K, Arai N, Cavenee W, Mischel PS. Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):9406-11. PMID: 26170313; PMCID: PMC4522814.
      13. Shen Y, Li J, Nitta M, Futalan D, Steed T, Treiber JM, Taich Z, Stevens D, Wykosky J, Chen HZ, Carter BS, Becher OJ, Kennedy R, Esashi F, Sarkaria JN, Furnari FB, Cavenee W, Desai A, Chen CC. Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition. Oncotarget. 2015 May 20; 6(14):11751-67. PMID: 26059434; PMCID: PMC4494902.
      14. Furnari FB, Cloughesy TF, Cavenee W, Mischel PS. Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma. Nat Rev Cancer. 2015 May; 15(5):302-10. PMID: 25855404; PMCID: PMC4875778.
      15. Chen K, Yang D, Li X, Sun B, Song F, Cao W, Brat DJ, Gao Z, Li H, Liang H, Zhao Y, Zheng H, Li M, Buckner J, Patterson SD, Ye X, Reinhard C, Bhathena A, Joshi D, Mischel PS, Croce CM, Wang YM, Raghavakaimal S, Li H, Lu X, Pan Y, Chang H, Ba S, Luo L, Cavenee W, Zhang W, Hao X. Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):1107-12. PMID: 25583476; PMCID: PMC4313862.
      16. Wu SH, Bi JF, Cloughesy T, Cavenee W, Mischel PS. Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance. Cancer Biol Med. 2014 Dec; 11(4):255-63. PMID: 25610711; PMCID: PMC4296088.
      17. Wykosky J, Hu J, Gomez GG, Taylor T, Villa GR, Pizzo D, VandenBerg SR, Thorne AH, Chen CC, Mischel PS, Gonias SL, Cavenee W, Furnari FB. A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma. Cancer Res. 2015 Jan 15; 75(2):394-404. PMID: 25432173; PMCID: PMC4297573.
      18. Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata M, Nakano I, Grandis JR, McLendon RE, Bigner DD, Lin HK, Furnari FB, Cavenee W, Hu B, Yan H, Cheng SY. EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. J Clin Invest. 2014 Sep; 124(9):3741-56. PMID: 25061874; PMCID: PMC4151226.
      19. Masui K, Cavenee W, Mischel PS. mTORC2 in the center of cancer metabolic reprogramming. Trends Endocrinol Metab. 2014 Jul; 25(7):364-73. PMID: 24856037; PMCID: PMC4077930.
      20. Li J, Zhu S, Kozono D, Ng K, Futalan D, Shen Y, Akers JC, Steed T, Kushwaha D, Schlabach M, Carter BS, Kwon CH, Furnari F, Cavenee W, Elledge S, Chen CC. Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget. 2014 Feb 28; 5(4):882-93. PMID: 24658464; PMCID: PMC4011590.
      21. Masui K, Cavenee W, Mischel PS. mTORC2 dictates Warburg effect and drug resistance. Cell Cycle. 2014; 13(7):1053-4. PMID: 24583874; PMCID: PMC4013152.
      22. Gomez GG, Volinia S, Croce CM, Zanca C, Li M, Emnett R, Gutmann DH, Brennan CW, Furnari FB, Cavenee W. Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity. Cancer Res. 2014 Mar 01; 74(5):1429-39. PMID: 24436148; PMCID: PMC3947420.
      23. Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao PN, Kornblum HI, Heath JR, Cavenee W, Furnari FB, Mischel PS. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science. 2014 Jan 03; 343(6166):72-6. PMID: 24310612; PMCID: PMC4049335.
      24. Gomez GG, Wykosky J, Zanca C, Furnari FB, Cavenee W. Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks. Cancer Biol Med. 2013 Dec; 10(4):192-205. PMID: 24349829; PMCID: PMC3860350.
      25. Masui K, Tanaka K, Akhavan D, Babic I, Gini B, Matsutani T, Iwanami A, Liu F, Villa GR, Gu Y, Campos C, Zhu S, Yang H, Yong WH, Cloughesy TF, Mellinghoff IK, Cavenee W, Shaw RJ, Mischel PS. mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metab. 2013 Nov 05; 18(5):726-39. PMID: 24140020; PMCID: PMC3840163.
      26. Gini B, Zanca C, Guo D, Matsutani T, Masui K, Ikegami S, Yang H, Nathanson D, Villa GR, Shackelford D, Zhu S, Tanaka K, Babic I, Akhavan D, Lin K, Assuncao A, Gu Y, Bonetti B, Mortensen DS, Xu S, Raymon HK, Cavenee W, Furnari FB, James CD, Kroemer G, Heath JR, Hege K, Chopra R, Cloughesy TF, Mischel PS. The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. Clin Cancer Res. 2013 Oct 15; 19(20):5722-32. PMID: 24030701; PMCID: PMC3815450.
      27. Cloughesy TF, Cavenee W, Mischel PS. Glioblastoma: from molecular pathology to targeted treatment. Annu Rev Pathol. 2014; 9:1-25. PMID: 23937436.
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      28. Feng H, Hu B, Vuori K, Sarkaria JN, Furnari FB, Cavenee W, Cheng SY. EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180. Oncogene. 2014 May 08; 33(19):2504-12. PMID: 23728337; PMCID: PMC3883905.
      29. Babic I, Anderson ES, Tanaka K, Guo D, Masui K, Li B, Zhu S, Gu Y, Villa GR, Akhavan D, Nathanson D, Gini B, Mareninov S, Li R, Camacho CE, Kurdistani SK, Eskin A, Nelson SF, Yong WH, Cavenee W, Cloughesy TF, Christofk HR, Black DL, Mischel PS. EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. Cell Metab. 2013 Jun 04; 17(6):1000-8. PMID: 23707073; PMCID: PMC3679227.
      30. Iwanami A, Cloughesy TF, Cavenee W, Mischel PS. Arsenic reverses glioblastoma resistance to mTOR-targeted therapies. Cell Cycle. 2013 May 15; 12(10):1473-4. PMID: 23624839; PMCID: PMC3680520.
      31. Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee W, Bensinger SJ, Mischel PS. De-repression of PDGFRß transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Cancer Discov. 2013 May; 3(5):534-47. PMID: 23533263; PMCID: PMC3651754.
      32. Masui K, Gini B, Wykosky J, Zanca C, Mischel PS, Furnari FB, Cavenee W. A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments. Carcinogenesis. 2013 Apr; 34(4):725-38. PMID: 23455378; PMCID: PMC3616676.
      33. Iwanami A, Gini B, Zanca C, Matsutani T, Assuncao A, Nael A, Dang J, Yang H, Zhu S, Kohyama J, Kitabayashi I, Cavenee W, Cloughesy TF, Furnari FB, Nakamura M, Toyama Y, Okano H, Mischel PS. PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4339-44. PMID: 23440206; PMCID: PMC3600508.
      34. Read RD, Fenton TR, Gomez GG, Wykosky J, Vandenberg SR, Babic I, Iwanami A, Yang H, Cavenee W, Mischel PS, Furnari FB, Thomas JB. A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. PLoS Genet. 2013; 9(2):e1003253. PMID: 23459592; PMCID: PMC3573097.
      35. Cavenee W. Genetic driver events in premalignancy: LOH validated for marking the risk of oral cancer. Cancer Prev Res (Phila). 2012 Sep; 5(9):1073-4. PMID: 22911109.
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      36. Fenton TR, Nathanson D, Ponte de Albuquerque C, Kuga D, Iwanami A, Dang J, Yang H, Tanaka K, Oba-Shinjo SM, Uno M, Inda MM, Wykosky J, Bachoo RM, James CD, DePinho RA, Vandenberg SR, Zhou H, Marie SK, Mischel PS, Cavenee W, Furnari FB. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14164-9. PMID: 22891331; PMCID: PMC3435194.
      37. Latha K, Li M, Chumbalkar V, Gururaj A, Hwang Y, Dakeng S, Sawaya R, Aldape K, Cavenee W, Bogler O, Furnari FB. Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter. Int J Cancer. 2013 Feb 01; 132(3):509-20. PMID: 22729867; PMCID: PMC3802533.
      38. Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, Dunn IF, Agarwalla PK, Chheda MG, Campos B, Wang A, Brennan C, Ligon KL, Furnari F, Cavenee W, Depinho RA, Chin L, Hahn WC. Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev. 2012 Apr 15; 26(8):756-84. PMID: 22508724; PMCID: PMC3337451.
      39. Taylor TE, Furnari FB, Cavenee W. Targeting EGFR for treatment of glioblastoma: molecular basis to overcome resistance. Curr Cancer Drug Targets. 2012 Mar; 12(3):197-209. PMID: 22268382; PMCID: PMC3464093.
      40. Feng H, Hu B, Jarzynka MJ, Li Y, Keezer S, Johns TG, Tang CK, Hamilton RL, Vuori K, Nishikawa R, Sarkaria JN, Fenton T, Cheng T, Furnari FB, Cavenee W, Cheng SY. Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3018-23. PMID: 22323579; PMCID: PMC3286964.
      41. Li M, Mukasa A, Inda MM, Zhang J, Chin L, Cavenee W, Furnari F. Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma. J Exp Med. 2011 Dec 19; 208(13):2657-73. PMID: 22162832; PMCID: PMC3244036.
      42. Bonavia R, Inda MM, Vandenberg S, Cheng SY, Nagane M, Hadwiger P, Tan P, Sah DW, Cavenee W, Furnari FB. EGFRvIII promotes glioma angiogenesis and growth through the NF-?B, interleukin-8 pathway. Oncogene. 2012 Sep 06; 31(36):4054-66. PMID: 22139077; PMCID: PMC3537826.
      43. Feng H, Hu B, Liu KW, Li Y, Lu X, Cheng T, Yiin JJ, Lu S, Keezer S, Fenton T, Furnari FB, Hamilton RL, Vuori K, Sarkaria JN, Nagane M, Nishikawa R, Cavenee W, Cheng SY. Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRa-stimulated glioma tumorigenesis in mice and humans. J Clin Invest. 2011 Dec; 121(12):4670-84. PMID: 22080864; PMCID: PMC3223070.
      44. Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, De Jesus J, Amzajerdi AN, Zhang Y, Dibble CC, Dan H, Rinkenbaugh A, Yong WH, Vinters HV, Gera JF, Cavenee W, Cloughesy TF, Manning BD, Baldwin AS, Mischel PS. Oncogenic EGFR signaling activates an mTORC2-NF-?B pathway that promotes chemotherapy resistance. Cancer Discov. 2011 Nov; 1(6):524-38. PMID: 22145100; PMCID: PMC3229221.
      45. Hu J, Jo M, Cavenee W, Furnari F, VandenBerg SR, Gonias SL. Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15984-9. PMID: 21896743; PMCID: PMC3179096.
      46. Cvrljevic AN, Akhavan D, Wu M, Martinello P, Furnari FB, Johnston AJ, Guo D, Pike L, Cavenee W, Scott AM, Mischel PS, Hoogenraad NJ, Johns TG. Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism. J Cell Sci. 2011 Sep 01; 124(Pt 17):2938-50. PMID: 21878501; PMCID: PMC3706030.
      47. Wang Y, Huang JW, Li M, Cavenee W, Mitchell PS, Zhou X, Tewari M, Furnari FB, Taniguchi T. MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression. Mol Cancer Res. 2011 Aug; 9(8):1100-11. PMID: 21693595; PMCID: PMC3157593.
      48. Bonavia R, Inda MM, Cavenee W, Furnari FB. Heterogeneity maintenance in glioblastoma: a social network. Cancer Res. 2011 Jun 15; 71(12):4055-60. PMID: 21628493; PMCID: PMC3117065.
      49. Chumbalkar V, Latha K, Hwang Y, Maywald R, Hawley L, Sawaya R, Diao L, Baggerly K, Cavenee W, Furnari FB, Bogler O. Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ?EGFR. J Proteome Res. 2011 Mar 04; 10(3):1343-52. PMID: 21214269; PMCID: PMC3049961.
      50. Wykosky J, Fenton T, Furnari F, Cavenee W. Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations. Chin J Cancer. 2011 Jan; 30(1):5-12. PMID: 21192840; PMCID: PMC3359794.
      51. Staquicini FI, Ozawa MG, Moya CA, Driessen WH, Barbu EM, Nishimori H, Soghomonyan S, Flores LG, Liang X, Paolillo V, Alauddin MM, Basilion JP, Furnari FB, Bogler O, Lang FF, Aldape KD, Fuller GN, Höök M, Gelovani JG, Sidman RL, Cavenee W, Pasqualini R, Arap W. Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma. J Clin Invest. 2011 Jan; 121(1):161-73. PMID: 21183793; PMCID: PMC3007161.
      52. Inda MM, Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, Brennan C, Johns TG, Bachoo R, Hadwiger P, Tan P, Depinho RA, Cavenee W, Furnari F. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev. 2010 Aug 15; 24(16):1731-45. PMID: 20713517; PMCID: PMC2922502.
      53. Huh SJ, Chen YL, Friedman SL, Liao J, Huang HJ, Cavenee W, Robertson GP. KLF6 Gene and early melanoma development in a collagen I-rich extracellular environment. J Natl Cancer Inst. 2010 Aug 04; 102(15):1131-47. PMID: 20660366; PMCID: PMC2914760.
      54. Nitta M, Kozono D, Kennedy R, Stommel J, Ng K, Zinn PO, Kushwaha D, Kesari S, Inda MM, Wykosky J, Furnari F, Hoadley KA, Chin L, DePinho RA, Cavenee W, D'Andrea A, Chen CC. Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy. PLoS One. 2010 May 24; 5(5):e10767. PMID: 20532243; PMCID: PMC2879424.
      55. Wykosky J, Mukasa A, Furnari F, Cavenee W. Escape from targeted inhibition: the dark side of kinase inhibitor therapy. Cell Cycle. 2010 May; 9(9):1661-2. PMID: 20404502.
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      56. Huang PH, Miraldi ER, Xu AM, Kundukulam VA, Del Rosario AM, Flynn RA, Cavenee W, Furnari FB, White FM. Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth. Mol Biosyst. 2010 Jul; 6(7):1227-37. PMID: 20461251; PMCID: PMC3291333.
      57. Mukasa A, Wykosky J, Ligon KL, Chin L, Cavenee W, Furnari F. Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2616-21. PMID: 20133782; PMCID: PMC2823874.
      58. Lu KV, Zhu S, Cvrljevic A, Huang TT, Sarkaria S, Ahkavan D, Dang J, Dinca EB, Plaisier SB, Oderberg I, Lee Y, Chen Z, Caldwell JS, Xie Y, Loo JA, Seligson D, Chakravari A, Lee FY, Weinmann R, Cloughesy TF, Nelson SF, Bergers G, Graeber T, Furnari FB, James CD, Cavenee W, Johns TG, Mischel PS. Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer Res. 2009 Sep 01; 69(17):6889-98. PMID: 19690143; PMCID: PMC2770839.
      59. Mukherjee B, McEllin B, Camacho CV, Tomimatsu N, Sirasanagandala S, Nannepaga S, Hatanpaa KJ, Mickey B, Madden C, Maher E, Boothman DA, Furnari F, Cavenee W, Bachoo RM, Burma S. EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma. Cancer Res. 2009 May 15; 69(10):4252-9. PMID: 19435898; PMCID: PMC2694953.
      60. Garrett TP, Burgess AW, Gan HK, Luwor RB, Cartwright G, Walker F, Orchard SG, Clayton AH, Nice EC, Rothacker J, Catimel B, Cavenee W, Old LJ, Stockert E, Ritter G, Adams TE, Hoyne PA, Wittrup D, Chao G, Cochran JR, Luo C, Lou M, Huyton T, Xu Y, Fairlie WD, Yao S, Scott AM, Johns TG. Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5082-7. PMID: 19289842; PMCID: PMC2656555.
      61. James CD, Cavenee W. Stem cells for treating glioblastoma: how close to reality? Neuro Oncol. 2009 Apr; 11(2):101. PMID: 19237733; PMCID: PMC2718980.
      62. Read RD, Cavenee W, Furnari FB, Thomas JB. A drosophila model for EGFR-Ras and PI3K-dependent human glioma. PLoS Genet. 2009 Feb; 5(2):e1000374. PMID: 19214224; PMCID: PMC2636203.
      63. Wiedemeyer R, Brennan C, Heffernan TP, Xiao Y, Mahoney J, Protopopov A, Zheng H, Bignell G, Furnari F, Cavenee W, Hahn WC, Ichimura K, Collins VP, Chu GC, Stratton MR, Ligon KL, Futreal PA, Chin L. Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer Cell. 2008 Apr; 13(4):355-64. PMID: 18394558; PMCID: PMC2292238.
      64. Roeb W, Boyer A, Cavenee W, Arden KC. Guilt by association: PAX3-FOXO1 regulates gene expression through selective destabilization of the EGR1 transcription factor. Cell Cycle. 2008 Apr 01; 7(7):837-41. PMID: 18414034.
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      65. Yoshimoto K, Dang J, Zhu S, Nathanson D, Huang T, Dumont R, Seligson DB, Yong WH, Xiong Z, Rao N, Winther H, Chakravarti A, Bigner DD, Mellinghoff IK, Horvath S, Cavenee W, Cloughesy TF, Mischel PS. Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples. Clin Cancer Res. 2008 Jan 15; 14(2):488-93. PMID: 18223223.
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      66. Barrera LO, Li Z, Smith AD, Arden KC, Cavenee W, Zhang MQ, Green RD, Ren B. Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs. Genome Res. 2008 Jan; 18(1):46-59. PMID: 18042645; PMCID: PMC2134779.
      67. Roeb W, Boyer A, Cavenee W, Arden KC. PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18085-90. PMID: 17986608; PMCID: PMC2084300.
      68. Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee W. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 2007 Nov 01; 21(21):2683-710. PMID: 17974913.
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      69. Huang PH, Cavenee W, Furnari FB, White FM. Uncovering therapeutic targets for glioblastoma: a systems biology approach. Cell Cycle. 2007 Nov 15; 6(22):2750-4. PMID: 17986864.
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      70. Huang PH, Mukasa A, Bonavia R, Flynn RA, Brewer ZE, Cavenee W, Furnari FB, White FM. Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12867-72. PMID: 17646646; PMCID: PMC1937558.
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      91. Li Z, Van Calcar S, Qu C, Cavenee W, Zhang MQ, Ren B. A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8164-9. PMID: 12808131; PMCID: PMC166200.
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      97. Cavenee W. Muscling in on rhabdomyosarcoma. Nat Med. 2002 Nov; 8(11):1200-1. PMID: 12411939.
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      101. Johns TG, Stockert E, Ritter G, Jungbluth AA, Huang HJ, Cavenee W, Smyth FE, Hall CM, Watson N, Nice EC, Gullick WJ, Old LJ, Burgess AW, Scott AM. Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene. Int J Cancer. 2002 Mar 20; 98(3):398-408. PMID: 11920591.
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      102. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee W. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol. 2002 Mar; 61(3):215-25; discussion 226-9. PMID: 11895036.
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      103. Costello JF, Plass C, Cavenee W. Restriction landmark genome scanning. Methods Mol Biol. 2002; 200:53-70. PMID: 11951655.
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      105. Klingler-Hoffmann M, Fodero-Tavoletti MT, Mishima K, Narita Y, Cavenee W, Furnari FB, Huang HJ, Tiganis T. The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor. J Biol Chem. 2001 Dec 07; 276(49):46313-8. PMID: 11514572.
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      106. Guo P, Xu L, Pan S, Brekken RA, Yang ST, Whitaker GB, Nagane M, Thorpe PE, Rosenbaum JS, Su Huang HJ, Cavenee W, Cheng SY. Vascular endothelial growth factor isoforms display distinct activities in promoting tumor angiogenesis at different anatomic sites. Cancer Res. 2001 Dec 01; 61(23):8569-77. PMID: 11731444.
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      111. Nagane M, Huang HJ, Cavenee W. The potential of TRAIL for cancer chemotherapy. Apoptosis. 2001 Jun; 6(3):191-7. PMID: 11388668.
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      113. Biggs WH, Cavenee W, Arden KC. Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm Genome. 2001 Jun; 12(6):416-25. PMID: 11353388.
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      118. Mishima K, Mazar AP, Gown A, Skelly M, Ji XD, Wang XD, Jones TR, Cavenee W, Huang HJ. A peptide derived from the non-receptor-binding region of urokinase plasminogen activator inhibits glioblastoma growth and angiogenesis in vivo in combination with cisplatin. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8484-9. PMID: 10890917; PMCID: PMC26974.
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      149. Larson AA, Liao SY, Stanbridge EJ, Cavenee W, Hampton GM. Genetic alterations accumulate during cervical tumorigenesis and indicate a common origin for multifocal lesions. Cancer Res. 1997 Oct 01; 57(19):4171-6. PMID: 9331069.
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      153. Nagane M, Huang HJ, Cavenee W. Advances in the molecular genetics of gliomas. Curr Opin Oncol. 1997 May; 9(3):215-22. PMID: 9229142.
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      154. Ivanchuk SM, Eng C, Cavenee W, Mulligan LM. The expression of RET and its multiple splice forms in developing human kidney. Oncogene. 1997 Apr 17; 14(15):1811-8. PMID: 9150387.
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      155. Costello JF, Plass C, Arap W, Chapman VM, Held WA, Berger MS, Su Huang HJ, Cavenee W. Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Cancer Res. 1997 Apr 01; 57(7):1250-4. PMID: 9102208.
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      156. Arap W, Knudsen ES, Wang JY, Cavenee W, Huang HJ. Point mutations can inactivate in vitro and in vivo activities of p16(INK4a)/CDKN2A in human glioma. Oncogene. 1997 Feb 06; 14(5):603-9. PMID: 9053859.
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      157. Pietsch T, Valter MM, Wolf HK, von Deimling A, Huang HJ, Cavenee W, Wiestler OD. Expression and distribution of vascular endothelial growth factor protein in human brain tumors. Acta Neuropathol. 1997 Feb; 93(2):109-17. PMID: 9039457.
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      158. Huang HS, Nagane M, Klingbeil CK, Lin H, Nishikawa R, Ji XD, Huang CM, Gill GN, Wiley HS, Cavenee W. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem. 1997 Jan 31; 272(5):2927-35. PMID: 9006938.
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      159. Besnard-Guérin C, Winqvist R, Newsham I, Cavenee W. Population variation at the polymorphic ApaLI restriction enzyme site in intron 5 of the WT1 gene. Clin Genet. 1996 Dec; 50(6):555-7. PMID: 9147899.
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      160. Nagane M, Coufal F, Lin H, Bögler O, Cavenee W, Huang HJ. A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis. Cancer Res. 1996 Nov 01; 56(21):5079-86. PMID: 8895767.
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      161. Prigent SA, Nagane M, Lin H, Huvar I, Boss GR, Feramisco JR, Cavenee W, Huang HS. Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway. J Biol Chem. 1996 Oct 11; 271(41):25639-45. PMID: 8810340.
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      162. Han Y, Caday CG, Nanda A, Cavenee W, Huang HJ. Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors. Cancer Res. 1996 Sep 01; 56(17):3859-61. PMID: 8752145.
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      163. Wasserman LM, Newsham I, Huang HJ, Cavenee W. cAMP effects on myogenic gene expression in rhabdomyosarcoma cells. Exp Cell Res. 1996 Aug 25; 227(1):55-62. PMID: 8806451.
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      164. Cheng SY, Huang HJ, Nagane M, Ji XD, Wang D, Shih CC, Arap W, Huang CM, Cavenee W. Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8502-7. PMID: 8710899; PMCID: PMC38701.
      165. Arden KC, Anderson MJ, Finckenstein FG, Czekay S, Cavenee W. Detection of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma using the reverse transcriptase-polymerase chain reaction. Genes Chromosomes Cancer. 1996 Aug; 16(4):254-60. PMID: 8875239.
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      166. Black PM, Nomura K, Cavenee W, Kakizoe T, Mukai K. Report of the Ninth International Symposium of the Foundation for Promotion of Cancer Research: basic and clinical research in brain tumors. Jpn J Clin Oncol. 1996 Aug; 26(4):277-82. PMID: 8765189.
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      167. Hampton GM, Larson AA, Baergen RN, Sommers RL, Kern S, Cavenee W. Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: subregional mapping of chromosome 4 in cervical carcinoma. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6704-9. PMID: 8692882; PMCID: PMC39090.
      168. Costello JF, Berger MS, Huang HS, Cavenee W. Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res. 1996 May 15; 56(10):2405-10. PMID: 8625319.
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      169. Larson AA, Kern S, Sommers RL, Yokota J, Cavenee W, Hampton GM. Analysis of replication error (RER+) phenotypes in cervical carcinoma. Cancer Res. 1996 Mar 15; 56(6):1426-31. PMID: 8640835.
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      170. Besnard-Guérin C, Newsham I, Winqvist R, Cavenee W. A common region of loss of heterozygosity in Wilms' tumor and embryonal rhabdomyosarcoma distal to the D11S988 locus on chromosome 11p15.5. Hum Genet. 1996 Feb; 97(2):163-70. PMID: 8566947.
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      171. Furnari FB, Huang HJ, Cavenee W. Molecular biology of malignant degeneration of astrocytoma. Pediatr Neurosurg. 1996; 24(1):41-9. PMID: 8817614.
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      172. Bögler O, Huang HJ, Kleihues P, Cavenee W. The p53 gene and its role in human brain tumors. Glia. 1995 Nov; 15(3):308-27. PMID: 8586466.
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      173. Schwechheimer K, Huang S, Cavenee W. EGFR gene amplification--rearrangement in human glioblastomas. Int J Cancer. 1995 Jul 17; 62(2):145-8. PMID: 7622287.
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      174. Negrini M, Rasio D, Hampton GM, Sabbioni S, Rattan S, Carter SL, Rosenberg AL, Schwartz GF, Shiloh Y, Cavenee W. Definition and refinement of chromosome 11 regions of loss of heterozygosity in breast cancer: identification of a new region at 11q23.3. Cancer Res. 1995 Jul 15; 55(14):3003-7. PMID: 7606718.
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      175. Besnard-Guérin C, Cavenee W, Newsham I. The t(11;22)(p15.5;q11.23) in a retroperitoneal rhabdoid tumor also includes a regional deletion distal to CRYBB2 on 22q. Genes Chromosomes Cancer. 1995 Jul; 13(3):145-50. PMID: 7669732.
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      176. Bögler O, Huang HJ, Cavenee W. Loss of wild-type p53 bestows a growth advantage on primary cortical astrocytes and facilitates their in vitro transformation. Cancer Res. 1995 Jul 01; 55(13):2746-51. PMID: 7796398.
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      177. Herbst RA, Larson A, Weiss J, Cavenee W, Hampton GM, Arden KC. A defined region of loss of heterozygosity at 11q23 in cutaneous malignant melanoma. Cancer Res. 1995 Jun 15; 55(12):2494-6. PMID: 7780954.
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      178. Wales MM, Biel MA, el Deiry W, Nelkin BD, Issa JP, Cavenee W, Kuerbitz SJ, Baylin SB. p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat Med. 1995 Jun; 1(6):570-7. PMID: 7585125.
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      179. Nishikawa R, Furnari FB, Lin H, Arap W, Berger MS, Cavenee W, Su Huang HJ. Loss of P16INK4 expression is frequent in high grade gliomas. Cancer Res. 1995 May 01; 55(9):1941-5. PMID: 7728764.
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      180. Arap W, Nishikawa R, Furnari FB, Cavenee W, Huang HJ. Replacement of the p16/CDKN2 gene suppresses human glioma cell growth. Cancer Res. 1995 Mar 15; 55(6):1351-4. PMID: 7882335.
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      181. Cavenee W, White RL. The genetic basis of cancer. Sci Am. 1995 Mar; 272(3):72-9. PMID: 7871410.
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      182. Van Meir EG, Roemer K, Diserens AC, Kikuchi T, Rempel SA, Haas M, Huang HJ, Friedmann T, de Tribolet N, Cavenee W. Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells. Proc Natl Acad Sci U S A. 1995 Feb 14; 92(4):1008-12. PMID: 7862624; PMCID: PMC42626.
      183. Solomon E, Ponder BA, Cavenee W. Genetics and cancer: a second look. Introduction. Cancer Surv. 1995; 25:1-2. PMID: 8718509.
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      184. Newsham I, Kindler-Röhrborn A, Daub D, Cavenee W. A constitutional BWS-related t(11;16) chromosome translocation occurring in the same region of chromosome 16 implicated in Wilms' tumors. Genes Chromosomes Cancer. 1995 Jan; 12(1):1-7. PMID: 7534105.
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      185. Furnari FB, Huang HJ, Cavenee W. Genetics and malignant progression of human brain tumours. Cancer Surv. 1995; 25:233-75. PMID: 8718522.
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      186. Herbst RA, Nobori T, Cavenee W, Carson DA, Arden KC. Dinucleotide repeat polymorphism adjacent to CDKN2. Hum Mol Genet. 1994 Dec; 3(12):2265. PMID: 7881438.
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      187. Adesina AM, Nalbantoglu J, Cavenee W. p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma. Cancer Res. 1994 Nov 01; 54(21):5649-51. PMID: 7923211.
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      188. Van Meir EG, Polverini PJ, Chazin VR, Su Huang HJ, de Tribolet N, Cavenee W. Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nat Genet. 1994 Oct; 8(2):171-6. PMID: 7531056.
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      189. Hampton GM, Mannermaa A, Winqvist R, Alavaikko M, Blanco G, Taskinen PJ, Kiviniemi H, Newsham I, Cavenee W, Evans GA, Winquist R. Loss of heterozygosity in sporadic human breast carcinoma: a common region between 11q22 and 11q23.3. Cancer Res. 1994 Sep 01; 54(17):4586-9. PMID: 8062246.
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      190. Nishikawa R, Ji XD, Harmon RC, Lazar CS, Gill GN, Cavenee W, Huang HJ. A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7727-31. PMID: 8052651; PMCID: PMC44475.
      191. Herbst RA, Weiss J, Ehnis A, Cavenee W, Arden KC. Loss of heterozygosity for 10q22-10qter in malignant melanoma progression. Cancer Res. 1994 Jun 15; 54(12):3111-4. PMID: 8205526.
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      192. Besnard-Guérin C, Cavenee W, Newsham I. A new highly polymorphic DNA restriction site marker in the 5' region of the human tyrosine hydroxylase gene (TH) detecting loss of heterozygosity in human embryonal rhabdomyosarcoma. Hum Genet. 1994 Mar; 93(3):349-50. PMID: 7510263.
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      193. Newsham I, Daub D, Besnard-Guerin C, Cavenee W. Molecular sublocalization and characterization of the 11;22 translocation breakpoint in a malignant rhabdoid tumor. Genomics. 1994 Feb; 19(3):433-40. PMID: 8188285.
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      194. Van Meir EG, Kikuchi T, Tada M, Li H, Diserens AC, Wojcik BE, Huang HJ, Friedmann T, de Tribolet N, Cavenee W. Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Res. 1994 Feb 01; 54(3):649-52. PMID: 8306326.
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      195. Weiss J, Rubinfeld B, Polakis PG, McCormick F, Cavenee W, Arden KC. The RAP1GA1 locus for human Rap1-GTPase activating protein 1 maps to chromosome 1p36.1-->p35. Cytogenet Cell Genet. 1994; 66(1):18-21. PMID: 8275700.
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      196. Weiss J, Cavenee W, Herbst RA, Jung EG, Arden KC. Point mutations and allelic loss in the TP53 locus of cutaneous malignant melanomas. Arch Dermatol Res. 1994; 286(7):417-9. PMID: 7818283.
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      197. Winqvist R, Mannermaa A, Alavaikko M, Blanco G, Taskinen PJ, Kiviniemi H, Newsham I, Cavenee W. Refinement of regional loss of heterozygosity for chromosome 11p15.5 in human breast tumors. Cancer Res. 1993 Oct 01; 53(19):4486-8. PMID: 8402619.
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      198. Karlbom AE, James CD, Boethius J, Cavenee W, Collins VP, Nordenskjöld M, Larsson C. Loss of heterozygosity in malignant gliomas involves at least three distinct regions on chromosome 10. Hum Genet. 1993 Sep; 92(2):169-74. PMID: 8370584.
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      199. Gessler M, König A, Moore J, Qualman S, Arden K, Cavenee W, Bruns G. Homozygous inactivation of WT1 in a Wilms' tumor associated with the WAGR syndrome. Genes Chromosomes Cancer. 1993 Jul; 7(3):131-6. PMID: 7687865.
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      200. Weiss J, Schwechheimer K, Cavenee W, Herlyn M, Arden KC. Mutation and expression of the p53 gene in malignant melanoma cell lines. Int J Cancer. 1993 Jun 19; 54(4):693-9. PMID: 8514460.
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      201. Makos M, Nelkin BD, Chazin VR, Cavenee W, Brodeur GM, Baylin SB. DNA hypermethylation is associated with 17p allelic loss in neural tumors. Cancer Res. 1993 Jun 15; 53(12):2715-8. PMID: 8389241.
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      202. Schwechheimer K, Cavenee W. Genetics of cancer predisposition and progression. Clin Investig. 1993 Jun; 71(6):488-502. PMID: 8353410.
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      203. Rempel SA, Schwechheimer K, Davis RL, Cavenee W, Rosenblum ML. Loss of heterozygosity for loci on chromosome 10 is associated with morphologically malignant meningioma progression. Cancer Res. 1993 May 15; 53(10 Suppl):2386-92. PMID: 8485725.
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      204. Gerken S, Leppert M, O'Connell P, Cavenee W, James CD, Ballard L, Stauffer D, Elsner T, Plaetke R, Lalouel JM. A genetic linkage map with 29 loci spanning human chromosome 13q. Genomics. 1993 May; 16(2):515-9. PMID: 8100218.
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      205. Kikuchi T, Rempel SA, Rutz HP, de Tribolet N, Mulligan L, Cavenee W, Jothy S, Leduy L, Van Meir EG. Turcot's syndrome of glioma and polyposis occurs in the absence of germ line mutations of exons 5 to 9 of the p53 gene. Cancer Res. 1993 Mar 01; 53(5):957-61. PMID: 8439970.
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      206. Cavenee W. A siren song from tumor cells. J Clin Invest. 1993 Jan; 91(1):3. PMID: 7678605; PMCID: PMC329986.
      207. Newsham I, Artigas C, Lasko D, Cavenee W. Characterization of polymorphic and monomorphic loci for chromosome 11p15.5. Mamm Genome. 1993; 4(8):451-3. PMID: 8104058.
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      208. Newsham I, Cavenee W. Tumors and developmental anomalies associated with Wilms tumor. Med Pediatr Oncol. 1993; 21(3):199-204. PMID: 8383280.
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      209. Ikizler Y, van Meyel DJ, Ramsay DA, Abdallah GL, Allaster RM, Macdonald DR, Cavenee W, Cairncross JG. Gliomas in families. Can J Neurol Sci. 1992 Nov; 19(4):492-7. PMID: 1423046.
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      210. Cavenee W. Accumulation of genetic defects during astrocytoma progression. Cancer. 1992 Sep 15; 70(6 Suppl):1788-93. PMID: 1325281.
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      211. Fong CT, White PS, Peterson K, Sapienza C, Cavenee W, Kern SE, Vogelstein B, Cantor AB, Look AT, Brodeur GM. Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas. Cancer Res. 1992 Apr 01; 52(7):1780-5. PMID: 1551108.
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      212. Loh WE, Scrable HJ, Livanos E, Arboleda MJ, Cavenee W, Oshimura M, Weissman BE. Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A. 1992 Mar 01; 89(5):1755-9. PMID: 1347425; PMCID: PMC48531.
      213. Knudson A, Vande Woude GF, Friend SH, Cavenee W, Brodeur GM. Developmental genetics and childhood cancer. AACR special conference in cancer research. Cancer Res. 1991 Oct 01; 51(19):5435-9. PMID: 1655251.
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      214. Tonin PN, Scrable H, Shimada H, Cavenee W. Muscle-specific gene expression in rhabdomyosarcomas and stages of human fetal skeletal muscle development. Cancer Res. 1991 Oct 01; 51(19):5100-6. PMID: 1717137.
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      215. Cavenee W. Charles S. Mott Prize. Recessive mutations in the causation of human cancer. Cancer. 1991 May 15; 67(10):2431-5. PMID: 2015543.
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      216. Mikkelsen T, Cairncross JG, Cavenee W. Genetics of the malignant progression of astrocytoma. J Cell Biochem. 1991 May; 46(1):3-8. PMID: 1874797.
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      217. Ekstrand AJ, James CD, Cavenee W, Seliger B, Pettersson RF, Collins VP. Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res. 1991 Apr 15; 51(8):2164-72. PMID: 2009534.
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      218. Cavenee W, Scrable HJ, James CD. Molecular genetics of human cancer predisposition and progression. Mutat Res. 1991 Apr; 247(2):199-202. PMID: 2011137.
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      219. James CD, He J, Carlbom E, Nordenskjold M, Cavenee W, Collins VP. Chromosome 9 deletion mapping reveals interferon alpha and interferon beta-1 gene deletions in human glial tumors. Cancer Res. 1991 Mar 15; 51(6):1684-8. PMID: 1998958.
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      220. Newsham I, Claussen U, Lüdecke HJ, Mason M, Senger G, Horsthemke B, Cavenee W. Microdissection of chromosome band 11p15.5: characterization of probes mapping distal to the HBBC locus. Genes Chromosomes Cancer. 1991 Mar; 3(2):108-16. PMID: 1676905.
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      221. Phaneuf D, Labelle Y, Bérubé D, Arden K, Cavenee W, Gagné R, Tanguay RM. Cloning and expression of the cDNA encoding human fumarylacetoacetate hydrolase, the enzyme deficient in hereditary tyrosinemia: assignment of the gene to chromosome 15. Am J Hum Genet. 1991 Mar; 48(3):525-35. PMID: 1998338; PMCID: PMC1682993.
      222. McHaffie NP, Houwen R, Cavenee W, Cox DW. A polymorphism of D13S86 from the region 13q14.1 to 13q22. Nucleic Acids Res. 1991 Feb 11; 19(3):684. PMID: 1672759; PMCID: PMC333677.
      223. Lasko D, Cavenee W, Nordenskjöld M. Loss of constitutional heterozygosity in human cancer. Annu Rev Genet. 1991; 25:281-314. PMID: 1687498.
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      224. Cavenee W, Ponder B, Solomon E. Genetics and cancer. Eur J Cancer. 1991; 27(12):1706-7. PMID: 1782088.
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      225. Houwen RH, Pautler SE, Barwell JA, Arden K, Buchanan JA, James CD, Cavenee W, Buys CH, Cowell JK, Cox DW. Isolation and regional localization of 25 anonymous DNA probes on a chromosome 13 hybrid panel. Cytogenet Cell Genet. 1991; 57(2-3):87-90. PMID: 1914527.
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      226. Cavenee W. Recessive mutations in cancer predisposition and progression. Basic Life Sci. 1991; 57:171-80; discussion 180-1. PMID: 1667571.
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      227. Hansen MF, Morgan R, Sandberg AA, Cavenee W. Structural alterations at the putative retinoblastoma locus in some human leukemias and preleukemia. Cancer Genet Cytogenet. 1990 Oct 01; 49(1):15-23. PMID: 2397469.
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      228. Gennett IN, Cavenee W. Molecular genetics in the pathology and diagnosis of retinoblastoma. Brain Pathol. 1990 Sep; 1(1):25-32. PMID: 1669690.
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      229. Mulligan LM, Matlashewski GJ, Scrable HJ, Cavenee W. Mechanisms of p53 loss in human sarcomas. Proc Natl Acad Sci U S A. 1990 Aug; 87(15):5863-7. PMID: 2143022; PMCID: PMC54429.
      230. James CD, He J, Carlbom E, Mikkelsen T, Ridderheim PA, Cavenee W, Collins VP. Loss of genetic information in central nervous system tumors common to children and young adults. Genes Chromosomes Cancer. 1990 Jul; 2(2):94-102. PMID: 1980610.
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      231. Mikkelsen T, Cavenee W. Suppressors of the malignant phenotype. Cell Growth Differ. 1990 Apr; 1(4):201-7. PMID: 2128032.
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      232. Scrable HJ, Johnson DK, Rinchik EM, Cavenee W. Rhabdomyosarcoma-associated locus and MYOD1 are syntenic but separate loci on the short arm of human chromosome 11. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2182-6. PMID: 2315312; PMCID: PMC53650.
      233. Gessler M, Poustka A, Cavenee W, Neve RL, Orkin SH, Bruns GA. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature. 1990 Feb 22; 343(6260):774-8. PMID: 2154702.
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      234. Arden KC, Boutin JM, Djiane J, Kelly PA, Cavenee W. The receptors for prolactin and growth hormone are localized in the same region of human chromosome 5. Cytogenet Cell Genet. 1990; 53(2-3):161-5. PMID: 2369845.
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      235. James CD, Mikkelsen T, Cavenee W, Collins VP. Molecular genetic aspects of glial tumour evolution. Cancer Surv. 1990; 9(4):631-44. PMID: 1983210.
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      236. Scrable HJ, Sapienza C, Cavenee W. Genetic and epigenetic losses of heterozygosity in cancer predisposition and progression. Adv Cancer Res. 1990; 54:25-62. PMID: 2404380.
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      237. Scrable H, Cavenee W, Ghavimi F, Lovell M, Morgan K, Sapienza C. A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting. Proc Natl Acad Sci U S A. 1989 Oct; 86(19):7480-4. PMID: 2798419; PMCID: PMC298088.
      238. Mori N, Yokota J, Oshimura M, Cavenee W, Mizoguchi H, Noguchi M, Shimosato Y, Sugimura T, Terada M. Concordant deletions of chromosome 3p and loss of heterozygosity for chromosomes 13 and 17 in small cell lung carcinoma. Cancer Res. 1989 Sep 15; 49(18):5130-5. PMID: 2569931.
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      239. Scrable H, Witte D, Shimada H, Seemayer T, Sheng WW, Soukup S, Koufos A, Houghton P, Lampkin B, Cavenee W. Molecular differential pathology of rhabdomyosarcoma. Genes Chromosomes Cancer. 1989 Sep; 1(1):23-35. PMID: 2487144.
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      240. Cavenee W. Loss of heterozygosity in stages of malignancy. Clin Chem. 1989 Jul; 35(7 Suppl):B48-52. PMID: 2663235.
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      241. Seemayer TA, Cavenee W. Molecular mechanisms of oncogenesis. Lab Invest. 1989 May; 60(5):585-99. PMID: 2654471.
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      242. Koufos A, Grundy P, Morgan K, Aleck KA, Hadro T, Lampkin BC, Kalbakji A, Cavenee W. Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5. Am J Hum Genet. 1989 May; 44(5):711-9. PMID: 2539717; PMCID: PMC1715635.
      243. James CD, Carlbom E, Nordenskjold M, Collins VP, Cavenee W. Mitotic recombination of chromosome 17 in astrocytomas. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2858-62. PMID: 2565039; PMCID: PMC287018.
      244. Cavenee W. Mitotic abnormalities leading to cancer predisposition and progression. Cancer Detect Prev. 1989; 14(2):269-73. PMID: 2559800.
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      245. Higgins MJ, Hansen MF, Cavenee W, Lalande M. Molecular detection of chromosomal translocations that disrupt the putative retinoblastoma susceptibility locus. Mol Cell Biol. 1989 Jan; 9(1):1-5. PMID: 2927388; PMCID: PMC362138.
      246. Cavenee W. Tumor progression stage: specific losses of heterozygosity. Princess Takamatsu Symp. 1989; 20:33-42. PMID: 2488236.
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      247. Cavenee W. Current knowledge of heritable tumors. Birth Defects Orig Artic Ser. 1989; 25(2):29-43. PMID: 2655740.
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      248. Cavenee W, Hansen MF, Scrable HJ, James CD. Loss of genetic information in cancer. Ciba Found Symp. 1989; 142:79-88; discussion 88-92. PMID: 2743836.
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      249. Finver SN, Martiniere C, Kagan J, Cavenee W, Croce CM. The chromosome 11 region flanking the t(11;14) breakpoint in human T-ALL is deleted in Wilms' tumor hybrids. Oncogene Res. 1989; 5(2):143-8. PMID: 2558334.
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      250. Grundy P, Koufos A, Morgan K, Li FP, Meadows AT, Cavenee W. Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11. Nature. 1988 Nov 24; 336(6197):374-6. PMID: 2848199.
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      251. James CD, Carlbom E, Dumanski JP, Hansen M, Nordenskjold M, Collins VP, Cavenee W. Clonal genomic alterations in glioma malignancy stages. Cancer Res. 1988 Oct 01; 48(19):5546-51. PMID: 2901288.
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      252. Hansen MF, Cavenee W. Retinoblastoma and the progression of tumor genetics. Trends Genet. 1988 May; 4(5):125-8. PMID: 3070862.
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      253. Hansen MF, Cavenee W. Tumor suppressors: recessive mutations that lead to cancer. Cell. 1988 Apr 22; 53(2):173-4. PMID: 3282673.
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      254. Nordenskjold M, Cavenee W. Genetics and the etiology of solid tumors. Important Adv Oncol. 1988; 83-101. PMID: 3042611.
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      255. Wu J, Cavenee W, Miki T, Kidd KK. A polymorphic DNA marker on chromosome 10 linked to RBP3 on the MEN2A side. Cytogenet Cell Genet. 1988; 48(4):246-7. PMID: 2907872.
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      256. Hansen MF, Cavenee W. Genetics of cancer predisposition. Cancer Res. 1987 Nov 01; 47(21):5518-27. PMID: 2889524.
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      257. Scrable HJ, Witte DP, Lampkin BC, Cavenee W. Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping. Nature. 1987 Oct 15-21; 329(6140):645-7. PMID: 3657988.
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      258. Buchanan JA, Cavenee W. Genetic markers for assessment of retinoblastoma predisposition. Dis Markers. 1987 Sep; 5(3):141-52. PMID: 3332257.
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      259. Gray A, Tam AW, Dull TJ, Hayflick J, Pintar J, Cavenee W, Koufos A, Ullrich A. Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene. DNA. 1987 Aug; 6(4):283-95. PMID: 3652904.
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      260. Hansen MF, Cavenee W. Retinoblastoma and osteosarcoma: the prototypic cancer family. Acta Paediatr Jpn. 1987 Aug; 29(4):526-33. PMID: 3144887.
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      261. Lundberg C, Skoog L, Cavenee W, Nordenskjöld M. Loss of heterozygosity in human ductal breast tumors indicates a recessive mutation on chromosome 13. Proc Natl Acad Sci U S A. 1987 Apr; 84(8):2372-6. PMID: 3031679; PMCID: PMC304653.
      262. Cavenee W. Identification of recessive mutations at human cancer loci. Birth Defects Orig Artic Ser. 1987; 23(3):93-107. PMID: 2820528.
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      263. Griffin CA, Emanuel BS, Hansen JR, Cavenee W, Myers JC. Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13. Proc Natl Acad Sci U S A. 1987 Jan; 84(2):512-6. PMID: 3025878; PMCID: PMC304239.
      264. Leppert M, Cavenee W, Callahan P, Holm T, O'Connell P, Thompson K, Lathrop GM, Lalouel JM, White R. A primary genetic map of chromosome 13q. Am J Hum Genet. 1986 Oct; 39(4):425-37. PMID: 3464200; PMCID: PMC1683981.
      265. Cavenee W, Koufos A, Hansen MF. Recessive mutant genes predisposing to human cancer. Mutat Res. 1986 Jul; 168(1):3-14. PMID: 3012326.
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      266. Cavenee W, Murphree AL, Shull MM, Benedict WF, Sparkes RS, Kock E, Nordenskjold M. Prediction of familial predisposition to retinoblastoma. N Engl J Med. 1986 May 08; 314(19):1201-7. PMID: 3702916.
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      267. Cavenee W. Chromosomal mechanisms in the initiation of human familial mixed cancers. Princess Takamatsu Symp. 1986; 17:171-9. PMID: 3332009.
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      268. Dryja TP, Rapaport JM, Epstein J, Goorin AM, Weichselbaum R, Koufos A, Cavenee W. Chromosome 13 homozygosity in osteosarcoma without retinoblastoma. Am J Hum Genet. 1986 Jan; 38(1):59-66. PMID: 3004203; PMCID: PMC1684712.
      269. Cavenee W. Recessive mutant genes predisposing to human cancer. Prog Clin Biol Res. 1986; 209A:575-82. PMID: 3749067.
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      270. Cavenee W, Hansen MF. Molecular genetics of human familial cancer. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 2:829-35. PMID: 3472764.
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      271. Hansen MF, Koufos A, Gallie BL, Phillips RA, Fodstad O, Brøgger A, Gedde-Dahl T, Cavenee W. Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition. Proc Natl Acad Sci U S A. 1985 Sep; 82(18):6216-20. PMID: 2994066; PMCID: PMC391023.
      272. Koufos A, Hansen MF, Copeland NG, Jenkins NA, Lampkin BC, Cavenee W. Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism. Nature. 1985 Jul 25-31; 316(6026):330-4. PMID: 2991766.
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      273. Cavenee W, Hansen MF, Nordenskjold M, Kock E, Maumenee I, Squire JA, Phillips RA, Gallie BL. Genetic origin of mutations predisposing to retinoblastoma. Science. 1985 Apr 26; 228(4698):501-3. PMID: 3983638.
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      274. Koufos A, Hansen MF, Lampkin BC, Workman ML, Copeland NG, Jenkins NA, Cavenee W. Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour. Nature. 1984 May 10-16; 309(5964):170-2. PMID: 6325936.
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      275. Nordenskjöld M, Cavenee W, Kumlin E, Kock E. [Carrier diagnosis of retinoblastoma with molecular genetic methods]. Lakartidningen. 1984 Mar 21; 81(12):1183-92. PMID: 6369047.
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      276. Dryja TP, Cavenee W, White R, Rapaport JM, Petersen R, Albert DM, Bruns GA. Homozygosity of chromosome 13 in retinoblastoma. N Engl J Med. 1984 Mar 01; 310(9):550-3. PMID: 6694706.
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      277. Cavenee W, Leach R, Mohandas T, Pearson P, White R. Isolation and regional localization of DNA segments revealing polymorphic loci from human chromosome 13. Am J Hum Genet. 1984 Jan; 36(1):10-24. PMID: 6320640; PMCID: PMC1684373.
      278. Cavenee W, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallie BL, Murphree AL, Strong LC, White RL. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature. 1983 Oct 27-Nov 2; 305(5937):779-84. PMID: 6633649.
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      279. Cavenee W, Baker RM. Characterization of dominant hamster cell mutants resistant to oxygenated sterols. Somatic Cell Genet. 1982 Sep; 8(5):557-74. PMID: 7135162.
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      280. Cavenee W, Chen HW, Kandutsch AA. Regulation of cholesterol biosynthesis in enucleated cells. J Biol Chem. 1981 Mar 25; 256(6):2675-81. PMID: 7204371.
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      281. Cavenee W, Chen HW, Kandutsch AA. Cell-substratum and cell-monolayer adhesion are dependent upon cellular cholesterol biosynthesis. Exp Cell Res. 1981 Jan; 131(1):31-40. PMID: 7447988.
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      282. Gibbons GF, Pullinger CR, Chen HW, Cavenee W, Kandutsch AA. Regulation of cholesterol biosynthesis in cultured cells by probable natural precursor sterols. J Biol Chem. 1980 Jan 25; 255(2):395-400. PMID: 7356622.
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      283. Cavenee W, Gibbons GF, Chen HW, Kandutsch AA. Effects of various oxygenated sterols on cellular sterol biosynthesis in Chinese hamster lung cells resistant to 25-hydroxycholesterol. Biochim Biophys Acta. 1979 Nov 21; 575(2):255-65. PMID: 508785.
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      284. Chen HW, Cavenee W, Kandutsch AA. Sterol synthesis in variant Chinese hamster lung cells selected for resistance to 25-hydroxycholesterol. Cross-resistance to 7-ketocholesterol, 20alpha-hydroxycholesterol, and serum. J Biol Chem. 1979 Feb 10; 254(3):715-20. PMID: 762093.
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      285. Johnston D, Cavenee W, Ramachandran CK, Melnykovych G. Cholesterol biosynthesis in a variety of cultured cells. Lack of correlation between synthesis and activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase caused by dexamethasone. Biochim Biophys Acta. 1979 Jan 29; 572(1):188-92. PMID: 760799.
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      286. Cavenee W, Melnykovych G. Elevation of HeLa cell 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by glucocorticoids: possible relationship to the cell cycle. J Cell Physiol. 1979 Jan; 98(1):199-211. PMID: 762197.
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      287. Cavenee W, Johnston D, Melnykovych G. Regulation of cholesterol biosynthesis in HeLa S3G cells by serum lipoproteins: dexamethasone-mediated interference with suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Proc Natl Acad Sci U S A. 1978 May; 75(5):2103-7. PMID: 209449; PMCID: PMC392499.
      288. Cavenee W, Melnykovych G. Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in HeLa cells by glucocorticoids. J Biol Chem. 1977 May 25; 252(10):3272-6. PMID: 16889.
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