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    Varykina Thackray

    TitleAssociate Professor In Residence
    SchoolUniversity of California, San Diego
    DepartmentReproductive Medicine
    Address9500 Gilman Drive #0674
    CA La Jolla 92093
    Phone858-822-7693
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      Collapse Research 
      Collapse Research Activities and Funding
      Transcriptional control of pituitary gonadotropin genes
      NIH R01HD067448Aug 23, 2011 - May 31, 2016
      Role: Principal Investigator
      Integration of PR and FoxO Signaling in Pituitary Gonadotropes
      NIH K01DK080467Sep 1, 2008 - Aug 31, 2011
      Role: Principal Investigator
      The Role of Smads and AR in FSHbeta Gene Expression
      NIH F32DK065437Sep 1, 2003 - Aug 31, 2006
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Kelley ST, Skarra DV, Rivera AJ, Thackray V. The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome. PLoS One. 2016; 11(1):e0146509. PMID: 26731268.
        View in: PubMed
      2. Kauffman AS, Thackray V, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175.
        View in: PubMed
      3. Skarra DV, Thackray V. FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes. Mol Cell Endocrinol. 2015 Apr 15; 405:14-24. PMID: 25676570.
        View in: PubMed
      4. Park CH, Skarra DV, Rivera AJ, Arriola DJ, Thackray V. Constitutively Active FOXO1 Diminishes Activin Induction of Fshb Transcription in Immortalized Gonadotropes. PLoS One. 2014; 9(11):e113839. PMID: 25423188.
        View in: PubMed
      5. Thackray V. Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):62-70. PMID: 24099863.
        View in: PubMed
      6. Skarra DV, Arriola DJ, Benson CA, Thackray V. Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes. Mol Endocrinol. 2013 Nov; 27(11):1825-39. PMID: 24065703.
        View in: PubMed
      7. Benson CA, Kurz TL, Thackray V. A human FSHB promoter SNP associated with low FSH levels in men impairs LHX3 binding and basal FSHB transcription. Endocrinology. 2013 Sep; 154(9):3016-21. PMID: 23766128.
        View in: PubMed
      8. Arriola DJ, Mayo SL, Skarra DV, Benson CA, Thackray V. FOXO1 transcription factor inhibits luteinizing hormone ß gene expression in pituitary gonadotrope cells. J Biol Chem. 2012 Sep 28; 287(40):33424-35. PMID: 22865884.
        View in: PubMed
      9. Breen KM, Thackray V, Hsu T, Mak-McCully RA, Coss D, Mellon PL. Stress levels of glucocorticoids inhibit LHß-subunit gene expression in gonadotrope cells. Mol Endocrinol. 2012 Oct; 26(10):1716-31. PMID: 22851703.
        View in: PubMed
      10. Ghochani Y, Saini JK, Mellon PL, Thackray V. FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone ß-subunit promoter. Endocrinology. 2012 Apr; 153(4):2023-33. PMID: 22294749.
        View in: PubMed
      11. Coss D, Mellon PL, Thackray V. A FoxL in the Smad house: activin regulation of FSH. Trends Endocrinol Metab. 2010 Sep; 21(9):562-8. PMID: 20598900.
        View in: PubMed
      12. Breen KM, Thackray V, Coss D, Mellon PL. Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology. 2010 Jun; 151(6):2669-80. PMID: 20357224.
        View in: PubMed
      13. Thackray V, Mellon PL, Coss D. Hormones in synergy: regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol. 2010 Jan 27; 314(2):192-203. PMID: 19747958.
        View in: PubMed
      14. Thackray V, Hunnicutt JL, Memon AK, Ghochani Y, Mellon PL. Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression. Endocrinology. 2009 May; 150(5):2395-403. PMID: 19106225.
        View in: PubMed
      15. Sasson R, Luu SH, Thackray V, Mellon PL. Glucocorticoids induce human glycoprotein hormone alpha-subunit gene expression in the gonadotrope. Endocrinology. 2008 Jul; 149(7):3643-55. PMID: 18403486.
        View in: PubMed
      16. Thackray V, Mellon PL. Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins. Endocrinology. 2008 Mar; 149(3):1091-102. PMID: 18079204.
        View in: PubMed
      17. McGillivray SM, Thackray V, Coss D, Mellon PL. Activin and glucocorticoids synergistically activate follicle-stimulating hormone beta-subunit gene expression in the immortalized LbetaT2 gonadotrope cell line. Endocrinology. 2007 Feb; 148(2):762-73. PMID: 17082263.
        View in: PubMed
      18. Thackray V, McGillivray SM, Mellon PL. Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope. Mol Endocrinol. 2006 Sep; 20(9):2062-79. PMID: 16675544.
        View in: PubMed
      19. Coss D, Thackray V, Deng CX, Mellon PL. Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol. 2005 Oct; 19(10):2610-23. PMID: 15961509.
        View in: PubMed
      20. Spady TJ, Shayya R, Thackray V, Ehrensberger L, Bailey JS, Mellon PL. Androgen regulates follicle-stimulating hormone beta gene expression in an activin-dependent manner in immortalized gonadotropes. Mol Endocrinol. 2004 Apr; 18(4):925-40. PMID: 14701939.
        View in: PubMed
      21. Thackray V, Toft DO, Nordeen SK. Novel activation step required for transcriptional competence of progesterone receptor on chromatin templates. Mol Endocrinol. 2003 Dec; 17(12):2543-53. PMID: 14551264.
        View in: PubMed