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    Varnavas Mouchlis

    TitleAssistant Project Scientist
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address9500 Gilman Drive #0601
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kokotou MG, Galiatsatou G, Magrioti V, Koutoulogenis G, Barbayianni E, Limnios D, Mouchlis V, Satpathy B, Navratil A, Dennis EA, Kokotos G. 2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2. Sci Rep. 2017 Aug 01; 7(1):7025. PMID: 28765606.
        View in: PubMed
      2. Smyrniotou A, Kokotou MG, Mouchlis V, Barbayianni E, Kokotos G, Dennis EA, Constantinou-Kokotou V. 2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A2 inhibitors. Bioorg Med Chem. 2016 Dec 08. PMID: 28034646.
        View in: PubMed
      3. Antonopoulou G, Magrioti V, Kokotou MG, Nikolaou A, Barbayianni E, Mouchlis V, Dennis EA, Kokotos G. 2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity. Bioorg Med Chem. 2016 Oct 1; 24(19):4544-54. PMID: 27522578; NIHMSID: NIHMS809927 [Available on 10/01/17].
        View in: PubMed
      4. Mouchlis V, Morisseau C, Hammock BD, Li S, McCammon JA, Dennis EA. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2. Bioorg Med Chem. 2016 May 10. PMID: 27320659.
        View in: PubMed
      5. Mouchlis V, Limnios D, Kokotou MG, Barbayianni E, Kokotos G, McCammon JA, Dennis EA. Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships. J Med Chem. 2016 May 12; 59(9):4403-14. PMID: 27087127.
        View in: PubMed
      6. Mouchlis V, Dennis EA. Membrane and inhibitor interactions of intracellular phospholipases A2. Adv Biol Regul. 2016 May; 61:17-24. PMID: 26774606.
        View in: PubMed
      7. Mouchlis V, Bucher D, McCammon JA, Dennis EA. Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):E516-25. PMID: 25624474.
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      8. Bucher D, Hsu YH, Mouchlis V, Dennis EA, McCammon JA. Insertion of the Ca²?-independent phospholipase A2 into a phospholipid bilayer via coarse-grained and atomistic molecular dynamics simulations. PLoS Comput Biol. 2013; 9(7):e1003156. PMID: 23935474.
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      9. Mouchlis V, Melagraki G, Mavromoustakos T, Kollias G, Afantitis A. Molecular modeling on pyrimidine-urea inhibitors of TNF-a production: an integrated approach using a combination of molecular docking, classification techniques, and 3D-QSAR CoMSIA. J Chem Inf Model. 2012 Mar 26; 52(3):711-23. PMID: 22360289.
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      10. Mouchlis V, Michopoulou V, Constantinou-Kokotou V, Mavromoustakos T, Dennis EA, Kokotos G. Binding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics. J Chem Inf Model. 2012 Jan 23; 52(1):243-54. PMID: 22196172.
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      11. Tzoupis H, Leonis G, Durdagi S, Mouchlis V, Mavromoustakos T, Papadopoulos MG. Binding of novel fullerene inhibitors to HIV-1 protease: insight through molecular dynamics and molecular mechanics Poisson-Boltzmann surface area calculations. J Comput Aided Mol Des. 2011 Oct; 25(10):959-76. PMID: 21969102.
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      12. Mouchlis V, Barbayianni E, Mavromoustakos TM, Kokotos G. The application of rational design on phospholipase A(2) inhibitors. Curr Med Chem. 2011; 18(17):2566-82. PMID: 21568891.
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      13. Mouchlis V, Magrioti V, Barbayianni E, Cermak N, Oslund RC, Mavromoustakos TM, Gelb MH, Kokotos G. Inhibition of secreted phospholipases A2 by 2-oxoamides based on a-amino acids: Synthesis, in vitro evaluation and molecular docking calculations. Bioorg Med Chem. 2011 Jan 15; 19(2):735-43. PMID: 21216150.
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      14. Mouchlis V, Mavromoustakos TM, Kokotos G. Molecular docking and 3D-QSAR CoMFA studies on indole inhibitors of GIIA secreted phospholipase A(2). J Chem Inf Model. 2010 Sep 27; 50(9):1589-601. PMID: 20795712.
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      15. Mouchlis V, Mavromoustakos TM, Kokotos G. Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor. J Comput Aided Mol Des. 2010 Feb; 24(2):107-15. PMID: 20130961.
        View in: PubMed
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