Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Tracy Handel

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentSchool of Pharmacy and Pharmaceutical Science
    Address9500 Gilman Drive #0684
    CA La Jolla 92093
    Phone858-822-6656
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Ph.D.California Institute of Technology

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Chemokine interaction with CXCR4 and ACKR3: structure and activation mechanisms
      NIH R01GM117424Sep 15, 2016 - May 31, 2020
      Role: Principal Investigator
      2016 Chemotactic Cytokines Gordon Research Conference & Gordon Research Seminar
      NIH R13AI124469Mar 15, 2016 - Feb 28, 2017
      Role: Principal Investigator
      Dissecting the interactions of gp120 with chemokine receptor CXCR4
      NIH R21AI121918Jan 15, 2016 - Dec 31, 2017
      Role: Principal Investigator
      Structure Determination of the Chemokine Receptor CCR2 with Novel Inhibitors
      NIH R21AI122211Jan 1, 2016 - Dec 31, 2017
      Role: Principal Investigator
      The structural plasticity of chemokine and gp120 recognition by CCR5
      NIH R01AI118985May 11, 2015 - Apr 30, 2020
      Role: Principal Investigator
      Synthetic Fabs for Crystallization of Chemokine:Receptor Complexes
      NIH R21AI101687Jul 24, 2012 - Jun 30, 2014
      Role: Principal Investigator
      Structure, Dynamics and Activation Mechanisms of Chemokine Receptors
      NIH U01GM094612Sep 30, 2010 - Jun 30, 2015
      Role: Principal Investigator
      Sensitive Deuterium Exchange MS for Membrane Proteins
      NIH R01GM093325Sep 30, 2010 - Aug 31, 2013
      Role: Principal Investigator
      Engineering Chemokine Receptor Signaling Complexes In Vitro
      NIH R01GM081763Jun 1, 2009 - May 31, 2013
      Role: Principal Investigator
      Hydrogen Deuterium Exchange Mapping of Chemokine Receptor Complex Interfaces
      NIH R21AI076961Jun 15, 2008 - May 31, 2011
      Role: Principal Investigator
      Structure-Function Studies &Molecular Interactions of Chemokines
      NIH R01AI037113Dec 1, 1994 - Nov 30, 2015
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Gustavsson M, Wang L, van Gils N, Stephens BS, Zhang P, Schall TJ, Yang S, Abagyan R, Chance MR, Kufareva I, Handel T. Structural basis of ligand interaction with atypical chemokine receptor 3. Nat Commun. 2017 Jan 18; 8:14135. PMID: 28098154.
        View in: PubMed
      2. Dyer DP, Migliorini E, Salanga CL, Thakar D, Handel T, Richter RP. Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization. Open Biol. 2017 Jan; 7(1). PMID: 28123055.
        View in: PubMed
      3. Zheng Y, Qin L, Zacarías NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P, Stamos D, Abagyan R, Cherezov V, Stevens RC, IJzerman AP, Heitman LH, Tebben A, Kufareva I, Handel T. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature. 2016 Dec 07. PMID: 27926736.
        View in: PubMed
      4. Wescott MP, Kufareva I, Paes C, Goodman JR, Thaker Y, Puffer BA, Berdougo E, Rucker JB, Handel T, Doranz BJ. Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices. Proc Natl Acad Sci U S A. 2016 Aug 30; 113(35):9928-33. PMID: 27543332.
        View in: PubMed
      5. Dyer DP, Salanga CL, Johns SC, Valdambrini E, Fuster MM, Milner CM, Day AJ, Handel T. The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions. J Biol Chem. 2016 Jun 10; 291(24):12627-40. PMID: 27044744.
        View in: PubMed
      6. Kufareva I, Gustavsson M, Holden LG, Qin L, Zheng Y, Handel T. Disulfide Trapping for Modeling and Structure Determination of Receptor: Chemokine Complexes. Methods Enzymol. 2016; 570:389-420. PMID: 26921956.
        View in: PubMed
      7. Gustavsson M, Zheng Y, Handel T. Production of Chemokine/Chemokine Receptor Complexes for Structural Biophysical Studies. Methods Enzymol. 2016; 570:233-60. PMID: 26921949.
        View in: PubMed
      8. Dyer DP, Salanga CL, Volkman BF, Kawamura T, Handel T. The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization. Glycobiology. 2016 Mar; 26(3):312-26. PMID: 26582609.
        View in: PubMed
      9. Yin X, Johns SC, El Ghazal R, Salanga CL, Handel T, Fuster MM. Examining Roles of Glycans in Chemokine-Mediated Dendritic-Endothelial Cell Interactions. Methods Enzymol. 2016; 570:335-55. PMID: 26921954.
        View in: PubMed
      10. Hanes MS, Salanga CL, Chowdry AB, Comerford I, McColl SR, Kufareva I, Handel T. Dual Targeting of the Chemokine Receptors CXCR4 and ACKR3 with Novel Engineered Chemokines. J Biol Chem. 2015 Sep 11; 290(37):22385-97. PMID: 26216880.
        View in: PubMed
      11. Handel T. The Structure of a CXCR4:Chemokine Complex. Front Immunol. 2015; 6:282. PMID: 26097480.
        View in: PubMed
      12. Deshauer C, Morgan AM, Ryan EO, Handel T, Prestegard JH, Wang X. Interactions of the Chemokine CCL5/RANTES with Medium-Sized Chondroitin Sulfate Ligands. Structure. 2015 Jun 2; 23(6):1066-77. PMID: 25982530.
        View in: PubMed
      13. Kufareva I, Salanga CL, Handel T. Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies. Immunol Cell Biol. 2015 Apr; 93(4):372-83. PMID: 25708536.
        View in: PubMed
      14. Qin L, Kufareva I, Holden LG, Wang C, Zheng Y, Zhao C, Fenalti G, Wu H, Han GW, Cherezov V, Abagyan R, Stevens RC, Handel T. Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science. 2015 Mar 6; 347(6226):1117-22. PMID: 25612609.
        View in: PubMed
      15. Kufareva I, Handel T, Abagyan R. Experiment-Guided Molecular Modeling of Protein-Protein Complexes Involving GPCRs. Methods Mol Biol. 2015; 1335:295-311. PMID: 26260608.
        View in: PubMed
      16. Kufareva I, Stephens BS, Holden LG, Qin L, Zhao C, Kawamura T, Abagyan R, Handel T. Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: Molecular modeling and experimental validation. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5363-72. PMID: 25468967.
        View in: PubMed
      17. Salanga CL, Dyer DP, Kiselar JG, Gupta S, Chance MR, Handel T. Multiple Glycosaminoglycan-binding Epitopes of Monocyte Chemoattractant Protein-3/CCL7 Enable It to Function as a Non-oligomerizing Chemokine. J Biol Chem. 2014 May 23; 289(21):14896-912. PMID: 24727473.
        View in: PubMed
      18. Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel T. A general method for site specific fluorescent labeling of recombinant chemokines. PLoS One. 2014; 9(1):e81454. PMID: 24489642.
        View in: PubMed
      19. Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel T. The Chemokine Receptor CCR1 Is Constitutively Active, Which Leads to G Protein-independent, ß-Arrestin-mediated Internalization. J Biol Chem. 2013 Nov 8; 288(45):32194-210. PMID: 24056371.
        View in: PubMed
      20. Ziarek JJ, Getschman AE, Butler SJ, Taleski D, Stephens B, Kufareva I, Handel T, Payne RJ, Volkman BF. Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery. ACS Chem Biol. 2013 Sep 20; 8(9):1955-63. PMID: 23802178.
        View in: PubMed
      21. Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum JL, Handel T, Tsimikas S, Miller YI. MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma. J Lipid Res. 2013 Jul; 54(7):1877-83. PMID: 23667177.
        View in: PubMed
      22. O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel T, Seshagiri S, Gutkind JS. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer. 2013 Jun; 13(6):412-24. PMID: 23640210.
        View in: PubMed
      23. Kufareva I, Stephens B, Gilliland CT, Wu B, Fenalti G, Hamel D, Stevens RC, Abagyan R, Handel T. A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer. Methods Mol Biol. 2013; 1013:93-127. PMID: 23625495.
        View in: PubMed
      24. Stephens B, Handel T. Chemokine receptor oligomerization and allostery. Prog Mol Biol Transl Sci. 2013; 115:375-420. PMID: 23415099.
        View in: PubMed
      25. Axelsson J, Xu D, Kang BN, Nussbacher JK, Handel T, Ley K, Sriramarao P, Esko JD. Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood. 2012 Aug 23; 120(8):1742-51. PMID: 22791291.
        View in: PubMed
      26. Fecteau JF, Bharati IS, O'Hayre M, Handel T, Kipps TJ, Messmer D. Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1). Mol Med. 2012; 18:19-28. PMID: 21979753.
        View in: PubMed
      27. Allen SJ, Hamel DJ, Handel T. A rapid and efficient way to obtain modified chemokines for functional and biophysical studies. Cytokine. 2011 Aug; 55(2):168-73. PMID: 21632261.
        View in: PubMed
      28. Yin X, Truty J, Lawrence R, Johns SC, Srinivasan RS, Handel T, Fuster MM. A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis. Mol Cancer. 2010; 9:316. PMID: 21172016.
        View in: PubMed
      29. Messmer D, Fecteau JF, O'Hayre M, Bharati IS, Handel T, Kipps TJ. Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib. Blood. 2011 Jan 20; 117(3):882-9. PMID: 21079155.
        View in: PubMed
      30. O'Hayre M, Salanga CL, Handel T, Hamel DJ. Emerging concepts and approaches for chemokine-receptor drug discovery. Expert Opin Drug Discov. 2010 Nov; 5(11):1109-22. PMID: 21132095.
        View in: PubMed
      31. Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel T, Cherezov V, Stevens RC. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science. 2010 Nov 19; 330(6007):1066-71. PMID: 20929726.
        View in: PubMed
      32. O'Hayre M, Salanga CL, Kipps TJ, Messmer D, Dorrestein PC, Handel T. Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis. PLoS One. 2010; 5(7):e11716. PMID: 20661426.
        View in: PubMed
      33. Handel T, Horuk R. Duffy antigen inhibitors: useful therapeutics for malaria? Trends Parasitol. 2010 Jul; 26(7):329-33. PMID: 20382562.
        View in: PubMed
      34. Guttman M, Prieto JH, Handel T, Domaille PJ, Komives EA. Structure of the minimal interface between ApoE and LRP. J Mol Biol. 2010 Apr 30; 398(2):306-19. PMID: 20303980.
        View in: PubMed
      35. Jansma AL, Kirkpatrick JP, Hsu AR, Handel T, Nietlispach D. NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27. J Biol Chem. 2010 May 7; 285(19):14424-37. PMID: 20200157.
        View in: PubMed
      36. Allen SJ, Ribeiro S, Horuk R, Handel T. Expression, purification and in vitro functional reconstitution of the chemokine receptor CCR1. Protein Expr Purif. 2009 Jul; 66(1):73-81. PMID: 19275940.
        View in: PubMed
      37. O'Hayre M, Salanga CL, Dorrestein PC, Handel T. Phosphoproteomic analysis of chemokine signaling networks. Methods Enzymol. 2009; 460:331-46. PMID: 19446733.
        View in: PubMed
      38. Winter JM, Jansma AL, Handel T, Moore BS. Formation of the pyridazine natural product azamerone by biosynthetic rearrangement of an aryl diazoketone. Angew Chem Int Ed Engl. 2009; 48(4):767-70. PMID: 19072974.
        View in: PubMed
      39. Hamel DJ, Sielaff I, Proudfoot AE, Handel T. Chapter 4. Interactions of chemokines with glycosaminoglycans. Methods Enzymol. 2009; 461:71-102. PMID: 19480915.
        View in: PubMed
      40. Jansma A, Handel T, Hamel DJ. Chapter 2. Homo- and hetero-oligomerization of chemokines. Methods Enzymol. 2009; 461:31-50. PMID: 19480913.
        View in: PubMed
      41. O'Hayre M, Salanga CL, Handel T, Allen SJ. Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment. Biochem J. 2008 Feb 1; 409(3):635-49. PMID: 18177271.
        View in: PubMed
      42. Allen SJ, Zabel BA, Kirkpatrick J, Butcher EC, Nietlispach D, Handel T. NMR assignment of human chemerin, a novel chemoattractant. Biomol NMR Assign. 2007 Dec; 1(2):171-3. PMID: 19636857.
        View in: PubMed
      43. Allen SJ, Crown SE, Handel T. Chemokine: receptor structure, interactions, and antagonism. Annu Rev Immunol. 2007; 25:787-820. PMID: 17291188.
        View in: PubMed
      44. Reynolds KA, Thomson JM, Corbett KD, Bethel CR, Berger JM, Kirsch JF, Bonomo RA, Handel T. Structural and computational characterization of the SHV-1 beta-lactamase-beta-lactamase inhibitor protein interface. J Biol Chem. 2006 Sep 8; 281(36):26745-53. PMID: 16809340.
        View in: PubMed
      45. Lau EK, Paavola CD, Johnson Z, Gaudry JP, Geretti E, Borlat F, Kungl AJ, Proudfoot AE, Handel T. Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo. J Biol Chem. 2004 May 21; 279(21):22294-305. PMID: 15033992.
        View in: PubMed
      46. Lougheed JC, Domaille PJ, Handel T. Solution structure and dynamics of melanoma inhibitory activity protein. J Biomol NMR. 2002 Mar; 22(3):211-23. PMID: 11991352.
        View in: PubMed
      Tracy's Networks
      Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Similar People
      People who share similar concepts with this person.
      _
      Same Department
      Physical Neighbors
      People whose addresses are nearby this person.
      _