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    Thomas Hnasko

    TitleAssistant Professor
    SchoolUniversity of California, San Diego
    DepartmentNeurosciences
    Address9500 Gilman Drive #0626
    CA La Jolla 92093
    Phone858-822-0672
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      Collapse Research 
      Collapse Research Activities and Funding
      Novel Molecular Genetic Approaches for the Prevention and Treatment of Parkinsons
      NIH/NINDS R21NS087496Sep 1, 2014 - Aug 31, 2016
      Role: Principal Investigator
      Role of Novel VTA Neurons in Addiction
      NIH/NIDA R01DA036612Apr 1, 2014 - Mar 31, 2019
      Role: Principal Investigator
      Genetic Elucidation of VTA Glutamate Neurons
      NIH/NIDA K01DA026504Jun 1, 2010 - May 31, 2015
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Fife KH, Gutierrez-Reed NA, Zell V, Bailly J, Lewis CM, Aron AR, Hnasko T. Causal role for the subthalamic nucleus in interrupting behavior. Elife. 2017 Jul 25; 6. PMID: 28742497.
        View in: PubMed
      2. Yoo JH, Zell V, Wu J, Punta C, Ramajayam N, Shen X, Faget L, Lilascharoen V, Lim BK, Hnasko T. Activation of Pedunculopontine Glutamate Neurons Is Reinforcing. J Neurosci. 2017 Jan 04; 37(1):38-46. PMID: 28053028.
        View in: PubMed
      3. Yoo JH, Zell V, Gutierrez-Reed N, Wu J, Ressler R, Shenasa MA, Johnson AB, Fife KH, Faget L, Hnasko T. Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement. Nat Commun. 2016 Dec 15; 7:13697. PMID: 27976722.
        View in: PubMed
      4. Faget L, Osakada F, Duan J, Ressler R, Johnson AB, Proudfoot JA, Yoo JH, Callaway EM, Hnasko T. Afferent Inputs to Neurotransmitter-Defined Cell Types in the Ventral Tegmental Area. Cell Rep. 2016 Jun 21; 15(12):2796-808. PMID: 27292633; PMCID: PMC4917450 [Available on 06/21/17].
      5. Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko T, Ingraham HA. Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output. Mol Metab. 2015 Nov; 4(11):857-66. PMID: 26629409; PMCID: PMC4632173.
      6. Hnasko T, Hnasko RM. The Western Blot. Methods Mol Biol. 2015; 1318:87-96. PMID: 26160567.
        View in: PubMed
      7. Faget L, Hnasko T. Tyramide Signal Amplification for Immunofluorescent Enhancement. Methods Mol Biol. 2015; 1318:161-72. PMID: 26160574.
        View in: PubMed
      8. Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko T, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K. Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J Neurosci. 2014 Oct 22; 34(43):14304-17. PMID: 25339743; PMCID: PMC4205554.
      9. Delwig A, Majumdar S, Ahern K, LaVail MM, Edwards R, Hnasko T, Copenhagen DR. Glutamatergic neurotransmission from melanopsin retinal ganglion cells is required for neonatal photoaversion but not adult pupillary light reflex. PLoS One. 2013; 8(12):e83974. PMID: 24391855; PMCID: PMC3877098.
      10. Li H, Fertuzinhos S, Mohns E, Hnasko T, Verhage M, Edwards R, Sestan N, Crair MC. Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission. Neuron. 2013 Sep 04; 79(5):970-86. PMID: 24012009; PMCID: PMC3768017.
      11. Bui TV, Akay T, Loubani O, Hnasko T, Jessell TM, Brownstone RM. Circuits for grasping: spinal dI3 interneurons mediate cutaneous control of motor behavior. Neuron. 2013 Apr 10; 78(1):191-204. PMID: 23583114; PMCID: PMC4535710.
      12. Hnasko T, Hjelmstad GO, Fields HL, Edwards RH. Ventral tegmental area glutamate neurons: electrophysiological properties and projections. J Neurosci. 2012 Oct 24; 32(43):15076-85. PMID: 23100428; PMCID: PMC3685320.
      13. Hnasko T, Edwards RH. Neurotransmitter corelease: mechanism and physiological role. Annu Rev Physiol. 2012; 74:225-43. PMID: 22054239; PMCID: PMC4090038.
      14. Talpalar AE, Endo T, Löw P, Borgius L, Hägglund M, Dougherty KJ, Ryge J, Hnasko T, Kiehn O. Identification of minimal neuronal networks involved in flexor-extensor alternation in the mammalian spinal cord. Neuron. 2011 Sep 22; 71(6):1071-84. PMID: 21943604.
        View in: PubMed
      15. Goh GY, Huang H, Ullman J, Borre L, Hnasko T, Trussell LO, Edwards RH. Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport. Nat Neurosci. 2011 Aug 28; 14(10):1285-92. PMID: 21874016; PMCID: PMC3183113.
      16. Koch SM, Dela Cruz CG, Hnasko T, Edwards RH, Huberman AD, Ullian EM. Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement. Neuron. 2011 Jul 28; 71(2):235-42. PMID: 21791283; PMCID: PMC3375067.
      17. Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko T, Edwards RH, Basbaum AI. VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22296-301. PMID: 21135246; PMCID: PMC3009833.
      18. Stuber GD, Hnasko T, Britt JP, Edwards RH, Bonci A. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. J Neurosci. 2010 Jun 16; 30(24):8229-33. PMID: 20554874; PMCID: PMC2918390.
      19. Hnasko T, Chuhma N, Zhang H, Goh GY, Sulzer D, Palmiter RD, Rayport S, Edwards RH. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron. 2010 Mar 11; 65(5):643-56. PMID: 20223200; PMCID: PMC2846457.
      20. Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, Hnasko T, Palmiter RD, Chavkin C. Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19168-73. PMID: 19864633; PMCID: PMC2776420.
      21. Hnasko T, Sotak BN, Palmiter RD. Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin. J Neurosci. 2007 Nov 14; 27(46):12484-8. PMID: 18003826.
        View in: PubMed
      22. Hnasko T, Edwards RH. Synaptic vesicles: half full or half empty? Neuron. 2006 Sep 07; 51(5):523-4. PMID: 16950150.
        View in: PubMed
      23. Hnasko T, Perez FA, Scouras AD, Stoll EA, Gale SD, Luquet S, Phillips PE, Kremer EJ, Palmiter RD. Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia. Proc Natl Acad Sci U S A. 2006 Jun 06; 103(23):8858-63. PMID: 16723393; PMCID: PMC1466546.
      24. Sotak BN, Hnasko T, Robinson S, Kremer EJ, Palmiter RD. Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding. Brain Res. 2005 Nov 09; 1061(2):88-96. PMID: 16226228.
        View in: PubMed
      25. Hnasko T, Szczypka MS, Alaynick WA, During MJ, Palmiter RD. A role for dopamine in feeding responses produced by orexigenic agents. Brain Res. 2004 Oct 15; 1023(2):309-18. PMID: 15374756.
        View in: PubMed
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