Thomas Hermann

Title(s)	Professor, Chemistry and Biochemistry
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Overview

Websites

Lab website

Research

Research Activities and Funding

Broad-spectrum inhibitors targeting the viral replication promoter conserved in dengue and Zika viruses
NIH R21AI159643Apr 1, 2021 - Mar 31, 2023
Role: Principal Investigator

2019 RNA Nanotechnology GRC/GRS
NIH R13TR002708Jan 1, 2019 - Dec 31, 2019
Role: Principal Investigator

Self-assembling RNA nanosensors
NSF CHE1608287Jun 1, 2016 - May 31, 2019
Role: Principal Investigator

Chemotherapy targeting human thymidylate synthase messenger RNA
NIH R01CA132753Jun 1, 2009 - May 31, 2014
Role: Principal Investigator

New Antiviral Therapies for Hepatitis C Infection
NIH R01AI072012Apr 15, 2007 - Mar 31, 2012
Role: Principal Investigator

Chemotherapy targeting conserved elements of the thymidylate synthase messenger RNA
American Cancer Society ACS-IRG #70- 002Jun 1, 2006 - May 31, 2007
Role: Principal Investigator

Rational Design of Antibiotics Targeted at the Ribosome
NIH R44AI051104Feb 15, 2002 - Nov 30, 2006
Role: Co-Principal Investigator

Rational Design of Antibiotics Targeted at the Ribosome
NIH R43AI051104Feb 15, 2002 - Feb 14, 2003
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Metalated Nucleic Acid Nanostructures. Methods Mol Biol. 2023; 2709:97-103. Zhang D, Hermann T. PMID: 37572274.

View in: PubMed Mentions: Fields:
Mol Molecular Biology
Translation:Cells
Nano-sandwich composite by kinetic trapping assembly from protein and nucleic acid. Nucleic Acids Res. 2021 09 27; 49(17):10098-10105. Chen S, Xing L, Zhang D, Monferrer A, Hermann T. PMID: 34500473; PMCID: PMC8464029.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Cells
A simple screening strategy for complex RNA-DNA hybrid nanoshapes. Methods. 2022 01; 197:106-111. Chen S, Monferrer A, Hermann T. PMID: 33631308.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Cells
RNA-DNA hybrid nanoshapes that self-assemble dependent on ligand binding. Nanoscale. 2020 Feb 07; 12(5):3302-3307. Chen S, Hermann T. PMID: 31971536.

View in: PubMed Mentions: 6 Fields:
Nan Nanotechnology
Translation:Cells
Versatile kit of robust nanoshapes self-assembling from RNA and DNA modules. Nat Commun. 2019 02 05; 10(1):608. Monferrer A, Zhang D, Lushnikov AJ, Hermann T. PMID: 30723214; PMCID: PMC6363791.

View in: PubMed Mentions: 14 Fields:
Bio Biology Sci Science
Translation:Cells
Design and Crystallography of Self-Assembling RNA Nanostructures. Methods Mol Biol. 2017; 1632:135-149. Boerneke MA, Hermann T. PMID: 28730437.

View in: PubMed Mentions: 1 Fields:
Mol Molecular Biology
Translation:Cells
Ligand Optimization by Improving Shape Complementarity at a Hepatitis C Virus RNA Target. ACS Chem Biol. 2016 12 16; 11(12):3263-3267. Charrette BP, Boerneke MA, Hermann T. PMID: 27775338.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry Bio Biology
Translation:Humans Cells
Small molecules targeting viral RNA. Wiley Interdiscip Rev RNA. 2016 11; 7(6):726-743. Hermann T. PMID: 27307213; PMCID: PMC7169885.

View in: PubMed Mentions: 67 Fields:
Mol Molecular Biology
Translation:Humans Animals
Crystal-Structure-Guided Design of Self-Assembling RNA Nanotriangles. Angew Chem Int Ed Engl. 2016 Mar 14; 55(12):4097-100. Boerneke MA, Dibrov SM, Hermann T. PMID: 26914842; PMCID: PMC4824544.

View in: PubMed Mentions: 23 Fields:
Che Chemistry
Translation:Cells
Structure of the HCV Internal Ribosome Entry Site Subdomain IIa RNA in Complex with a Viral Translation Inhibitor. Methods Mol Biol. 2016; 1320:329-35. Dibrov SM, Hermann T. PMID: 26227053.

View in: PubMed Mentions: 1 Fields:
Mol Molecular Biology
Translation:Cells
Non-coding RNA: Antibiotic tricks a switch. Nature. 2015 Oct 29; 526(7575):650-1. Hermann T. PMID: 26416738.

View in: PubMed Mentions: 2 Fields:
Sci Science
Translation:Animals Cells
Conformational flexibility of viral RNA switches studied by FRET. Methods. 2015 Dec; 91:35-39. Boerneke MA, Hermann T. PMID: 26381686; PMCID: PMC4684784.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry
Translation:Cells
Ligand-responsive RNA mechanical switches. RNA Biol. 2015; 12(8):780-6. Boerneke MA, Hermann T. PMID: 26158858; PMCID: PMC4615790.

View in: PubMed Mentions: 7 Fields:
Mol Molecular Biology
Translation:Cells
Analysis of mRNA recognition by human thymidylate synthase. Biosci Rep. 2014 Dec 23; 34(6):e00168. Brunn ND, Dibrov SM, Kao MB, Ghassemian M, Hermann T. PMID: 25423174; PMCID: PMC4274661.

View in: PubMed Mentions: 15 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site. Bioorg Med Chem Lett. 2014 Aug 01; 24(15):3521-5. Rynearson KD, Charrette B, Gabriel C, Moreno J, Boerneke MA, Dibrov SM, Hermann T. PMID: 24930829; PMCID: PMC4114401.

View in: PubMed Mentions: 12 Fields:
Bio Biochemistry Che Chemistry
Translation:Cells
Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site. Bioorg Med Chem Lett. 2014 Jul 15; 24(14):3113-7. Ding K, Wang A, Boerneke MA, Dibrov SM, Hermann T. PMID: 24856063; PMCID: PMC4096041.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry Che Chemistry
Translation:Cells
Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site. J Med Chem. 2014 Mar 13; 57(5):1694-707. Dibrov SM, Parsons J, Carnevali M, Zhou S, Rynearson KD, Ding K, Garcia Sega E, Brunn ND, Boerneke MA, Castaldi MP, Hermann T. PMID: 24138284; PMCID: PMC3954896.

View in: PubMed Mentions: 36 Fields:
Che Chemistry
Translation:Cells
Synthesis and crystal structure of a phenazine N-oxide. J Chem Crystallogr. 2013 Oct 01; 43(10):550-553. Ding K, Dibrov SM, Hermann T. PMID: 24159257; PMCID: PMC3804267.

View in: PubMed Mentions:
Crystal structure of a benzimidazole hepatitis C virus inhibitor free and in complex with the viral RNA target. J Chem Crystallogr. 2013 May; 43(5):235-239. Dibrov SM, Parker MA, Bergdahl BM, Hermann T. PMID: 23750099; PMCID: PMC3673731.

View in: PubMed Mentions: 2
Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA. Bioorg Med Chem. 2013 Oct 15; 21(20):6139-44. Zhou S, Rynearson KD, Ding K, Brunn ND, Hermann T. PMID: 23602522; PMCID: PMC3758467.

View in: PubMed Mentions: 18 Fields:
Bio Biochemistry Che Chemistry
Translation:Cells PHPublic Health
Targeting a regulatory element in human thymidylate synthase mRNA. Chembiochem. 2012 Dec 21; 13(18):2738-44. Brunn ND, Garcia Sega E, Kao MB, Hermann T. PMID: 23143777; PMCID: PMC3758747.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry
Translation:Humans Cells
Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches. Proc Natl Acad Sci U S A. 2012 Apr 03; 109(14):5223-8. Dibrov SM, Ding K, Brunn ND, Parker MA, Bergdahl BM, Wyles DL, Hermann T. PMID: 22431596; PMCID: PMC3325719.

View in: PubMed Mentions: 59 Fields:
Sci Science
Translation:Cells
Self-assembling RNA square. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6405-8. Dibrov SM, McLean J, Parsons J, Hermann T. PMID: 21464284; PMCID: PMC3080994.

View in: PubMed Mentions: 60 Fields:
Sci Science
Translation:Cells
Structure of an RNA dimer of a regulatory element from human thymidylate synthase mRNA. Acta Crystallogr D Biol Crystallogr. 2011 Feb; 67(Pt 2):97-104. Dibrov S, McLean J, Hermann T. PMID: 21245530; PMCID: PMC3045271.

View in: PubMed Mentions: 8 Fields:
Che Chemistry Techniques
Translation:Humans Cells
(3,4-Dihy-droxy-oxolan-2-yl)methyl 4-methyl-benzene-sulfonate. Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 06; 66(Pt 12):o3088. Dibrov S, Carnevali M, Hermann T. PMID: 21589395; PMCID: PMC3011728.

View in: PubMed Mentions: 1
A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site. Chembiochem. 2010 Jul 05; 11(10):1364-7. Carnevali M, Parsons J, Wyles DL, Hermann T. PMID: 20564282; PMCID: PMC3517111.

View in: PubMed Mentions: 20 Fields:
Bio Biochemistry
Translation:Cells
A model for the study of ligand binding to the ribosomal RNA helix h44. Nucleic Acids Res. 2010 Jul; 38(13):4458-65. Dibrov SM, Parsons J, Hermann T. PMID: 20215440; PMCID: PMC2910043.

View in: PubMed Mentions: 9 Fields:
Bio Biochemistry
Translation:Cells
1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams. Org Lett. 2010 Jan 15; 12(2):360-3. Dutta S, Higginson CJ, Ho BT, Rynearson KD, Dibrov SM, Hermann T. PMID: 20028082; PMCID: PMC2810123.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry
Translation:Cells
Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA. Nat Chem Biol. 2009 Nov; 5(11):823-5. Parsons J, Castaldi MP, Dutta S, Dibrov SM, Wyles DL, Hermann T. PMID: 19767736; PMCID: PMC2770845.

View in: PubMed Mentions: 78 Fields:
Bio Biology Che Chemistry
Translation:Cells
1-Cyclo-hexyl-2-(3-fur-yl)-1H-benzimidazole-5-carboxylic acid. Acta Crystallogr Sect E Struct Rep Online. 2009 Aug 12; 65(Pt 9):o2136. Dibrov S, Dutta S, Hermann T. PMID: 21577546; PMCID: PMC2970106.

View in: PubMed Mentions:
Aminoglycoside antibiotics: old drugs and new therapeutic approaches. Cell Mol Life Sci. 2007 Jul; 64(14):1841-52. Hermann T. PMID: 17447006.

View in: PubMed Mentions: 65 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Apramycin recognition by the human ribosomal decoding site. Blood Cells Mol Dis. 2007 May-Jun; 38(3):193-8. Hermann T, Tereshko V, Skripkin E, Patel DJ. PMID: 17258916.

View in: PubMed Mentions: 8 Fields:
Hem Hematology
Translation:Humans Cells
Functional architecture of HCV IRES domain II stabilized by divalent metal ions in the crystal and in solution. Angew Chem Int Ed Engl. 2007; 46(1-2):226-9. Dibrov SM, Johnston-Cox H, Weng YH, Hermann T. PMID: 17131443.

View in: PubMed Mentions: 35 Fields:
Che Chemistry
Translation:Cells
A-site model RNAs. Biochimie. 2006 Aug; 88(8):1021-6. Hermann T. PMID: 16872733.

View in: PubMed Mentions: 7 Fields:
Bio Biochemistry
Translation:Cells
Molecular recognition of RNA by neomycin and a restricted neomycin derivative. Angew Chem Int Ed Engl. 2005 Aug 19; 44(33):5329-34. Zhao F, Zhao Q, Blount KF, Han Q, Tor Y, Hermann T. PMID: 16037995.

View in: PubMed Mentions: 34 Fields:
Che Chemistry
Translation:Cells
Conformational constraint as a means for understanding RNA-aminoglycoside specificity. J Am Chem Soc. 2005 Jul 13; 127(27):9818-29. Blount KF, Zhao F, Hermann T, Tor Y. PMID: 15998086.

View in: PubMed Mentions: 35 Fields:
Che Chemistry
Translation:Cells
Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme. Chem Biol. 1998 Nov; 5(11):R277-83. Tor Y, Hermann T, Westhof E. PMID: 9831530.

View in: PubMed Mentions: 32 Fields:
Bio Biochemistry Bio Biology Che Chemistry
Translation:Cells