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    Theodore Friedmann

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0630
    CA La Jolla 92093
    Phone858-534-4268
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      Collapse Research 
      Collapse Research Activities and Funding
      Lesch-Nyhan Disease: A Model for Complex Genetic, Proteomic &Metabolic Pathways
      NIH/NIDDK R24DK082840Sep 30, 2008 - Aug 31, 2014
      Role: Principal Investigator
      GENETIC ABBERATIONS IN HPRT DEFICIENCY
      NIH/NINDS R01NS044544Apr 1, 2003 - Mar 31, 2008
      Role: Principal Investigator
      ARRAY SCREENING FOR LESCH NYHAN DISEASE
      NIH/NICHD R21HD039250Jul 15, 2000 - May 31, 2003
      Role: Principal Investigator
      GENE TRANSFER TO THE VASCULAR ENDOTHELIUM
      NIH/NHLBI R01HL064730May 1, 2000 - Apr 30, 2005
      Role: Principal Investigator
      GENE THERAPY OF HYPERCHOLESTEROLEMIA
      NIH/NIDDK R01DK049023Aug 1, 1995 - Jul 31, 2000
      Role: Principal Investigator
      RETROVIRAL VECTOR BASED GENE THERAPY FOR HEMOPHILIA B
      NIH/NHLBI R01HL053680Sep 30, 1994 - Aug 31, 2000
      Role: Principal Investigator
      GENE TRANSFER FOR SUPPRESSION OF THE TUMOR PHENOTYPE
      NIH/NCI R01CA058317May 1, 1992 - Apr 30, 1995
      Role: Principal Investigator
      TRANSDUCTION OF AIRWAY EPITHELIA BY RETROVIRAL VECTORS
      NIH/NHLBI R01HL047119Apr 1, 1991 - Mar 31, 1996
      Role: Principal Investigator
      CANCER SUPPRESSION BY THE RETINOBLASTOMA GENE
      NIH/NCI P01CA051495Feb 1, 1990 - Jan 31, 1995
      Role: Principal Investigator
      PHYSICAL MAP OF THE HUMAN X CHROMOSOME
      NIH/NHGRI R01HG000309Jul 1, 1989 - Jun 30, 1995
      Role: Principal Investigator
      PHYSICAL MAP OF THE HUMAN X CHROMOSOME
      NIH/NIGMS R01GM040790Jul 1, 1989 - Jun 30, 1994
      Role: Principal Investigator
      MODELS FOR CNS GENE THERAPY
      NIH/NICHD R01HD020034Apr 1, 1985 - Mar 31, 1996
      Role: Principal Investigator
      THE HUMAN HPRT GENE AND X CHROMOSOME ORGANIZATION
      NIH/NIGMS R01GM028223Aug 1, 1980 - Jul 31, 1987
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Friedmann T. Happy Anniversary. Mol Ther. 2007 Jun; 15(6):1035-1036. PMID: 28182920.
        View in: PubMed
      2. Friedmann T. An ASGCT Perspective on the National Academies Genome Editing Summit. Mol Ther. 2016 Feb; 24(1):1-2. PMID: 26854182; PMCID: PMC4754555 [Available on 02/01/17].
      3. Friedmann T, Jonlin EC, King NMP, Torbett BE, Wivel NA, Kaneda Y, Sadelain M. ASGCT and JSGT Joint Position Statement on Human Genomic Editing. Mol Ther. 2015 Aug; 23(8):1282. PMID: 26227250; PMCID: PMC4817859.
      4. Kang TH, Park Y, Bader JS, Friedmann T. The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation. PLoS One. 2013; 8(10):e74967. PMID: 24130677; PMCID: PMC3794013.
      5. Friedmann T, Flenker U, Georgakopoulos C, Alsayrafi M, Sottas PE, Williams SA, Gill RD. Evolving concepts and techniques for anti-doping. Bioanalysis. 2012 Jul; 4(13):1667-80. PMID: 22831482.
        View in: PubMed
      6. Corrigan-Curay J, Cohen-Haguenauer O, O'Reilly M, Ross SR, Fan H, Rosenberg N, Somia N, King N, Friedmann T, Dunbar C, Aiuti A, Naldini L, Baum C, von Kalle C, Kiem HP, Montini E, Bushman F, Sorrentino BP, Carrondo M, Malech H, Gahrton G, Shapiro R, Wolff L, Rosenthal E, Jambou R, Zaia J, Kohn DB. Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy. Mol Ther. 2012 Jun; 20(6):1084-94. PMID: 22652996; PMCID: PMC3369284.
      7. Mastrangelo L, Kim JE, Miyanohara A, Kang TH, Friedmann T. Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3377-82. PMID: 22331909; PMCID: PMC3295269.
      8. Friedmann T. The successful clinical use of viral vectors for human gene therapy. Preface. Methods Enzymol. 2012; 507:xvii-xx. PMID: 22365783.
        View in: PubMed
      9. Guibinga GH, Hrustanovic G, Bouic K, Jinnah HA, Friedmann T. MicroRNA-mediated dysregulation of neural developmental genes in HPRT deficiency: clues for Lesch-Nyhan disease? Hum Mol Genet. 2012 Feb 01; 21(3):609-22. PMID: 22042773; PMCID: PMC3259014.
      10. Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. J Am Coll Cardiol. 2011 Oct 11; 58(16):1715-27. PMID: 21982317; PMCID: PMC3230644.
      11. Kang TH, Guibinga GH, Jinnah HA, Friedmann T. HPRT deficiency coordinately dysregulates canonical Wnt and presenilin-1 signaling: a neuro-developmental regulatory role for a housekeeping gene? PLoS One. 2011 Jan 28; 6(1):e16572. PMID: 21305049; PMCID: PMC3030599.
      12. Friedmann T. How close are we to gene doping? Hastings Cent Rep. 2010 Mar-Apr; 40(2):20-2. PMID: 20391845.
        View in: PubMed
      13. Friedmann T, Rabin O, Frankel MS. Ethics. Gene doping and sport. Science. 2010 Feb 05; 327(5966):647-8. PMID: 20133558.
        View in: PubMed
      14. King CC, Bouic K, Friedmann T. A fractionation method to identify qauntitative changes in protein expression mediated by IGF-1 on the proteome of murine C2C12 myoblasts. Proteome Sci. 2009 Aug 11; 7:28. PMID: 19664293; PMCID: PMC2732595.
      15. Guibinga GH, Hsu S, Friedmann T. Deficiency of the housekeeping gene hypoxanthine-guanine phosphoribosyltransferase (HPRT) dysregulates neurogenesis. Mol Ther. 2010 Jan; 18(1):54-62. PMID: 19672249; PMCID: PMC2839227.
      16. Nienhuis A, Friedmann T. An integrated funding mechanism for clinical trials in human gene therapy. Mol Ther. 2009 Jul; 17(7):1117-8. PMID: 19564863; PMCID: PMC2835213.
      17. Bhasker CR, Friedmann T. Insulin-like growth factor-1 coordinately induces the expression of fatty acid and cholesterol biosynthetic genes in murine C2C12 myoblasts. BMC Genomics. 2008 Nov 11; 9:535. PMID: 19014463; PMCID: PMC2628395.
      18. Friedmann T. The ASGT and ethical codes for clinical research. Mol Ther. 2008 Oct; 16(10):1643-4. PMID: 18813316.
        View in: PubMed
      19. Guibinga GH, Song S, Loring J, Friedmann T. Characterization of the gene delivery properties of baculoviral-based virosomal vectors. J Virol Methods. 2008 Mar; 148(1-2):277-82. PMID: 18207578.
        View in: PubMed
      20. Guo LT, Friedmann T, King CC. Partial characterization of the proteome of the mouse striatum. Proteomics. 2007 Nov; 7(21):3867-9. PMID: 17922512.
        View in: PubMed
      21. Friedmann T. A new serious adverse event in a gene therapy study. Mol Ther. 2007 Nov; 15(11):1899-900. PMID: 17948042.
        View in: PubMed
      22. Friedmann T. A decade of accomplishments: gene therapy and the ASGT. Mol Ther. 2007 Sep; 15(9):1576-8. PMID: 17710079.
        View in: PubMed
      23. Song S, Friedmann T. Tissue-specific aberrations of gene expression in HPRT-deficient mice: functional complexity in a monogenic disease? Mol Ther. 2007 Aug; 15(8):1432-43. PMID: 17505472.
        View in: PubMed
      24. Guibinga GH, Friedmann T. Baculovirus GP64-pseudotyped HIV-based lentivirus vectors are stabilized against complement inactivation by codisplay of decay accelerating factor (DAF) or of a GP64-DAF fusion protein. Mol Ther. 2005 Apr; 11(4):645-51. PMID: 15771967.
        View in: PubMed
      25. Friedmann T. Lessons for the stem cell discourse from the gene therapy experience. Perspect Biol Med. 2005; 48(4):585-91. PMID: 16227669.
        View in: PubMed
      26. Friedmann T. Clinical gene therapy: lessons from the ether dome. Mol Ther. 2004 Aug; 10(2):205-6. PMID: 15294165.
        View in: PubMed
      27. Smith DW, Friedmann T. Discrepant effects of culture conditions on survival and function of dopaminergic neurons. Neuroreport. 2004 Apr 29; 15(6):1025-8. PMID: 15076727.
        View in: PubMed
      28. Guibinga GH, Hall FL, Gordon EM, Ruoslahti E, Friedmann T. Ligand-modified vesicular stomatitis virus glycoprotein displays a temperature-sensitive intracellular trafficking and virus assembly phenotype. Mol Ther. 2004 Jan; 9(1):76-84. PMID: 14741780.
        View in: PubMed
      29. Guibinga GH, Miyanohara A, Esko JD, Friedmann T. Cell surface heparan sulfate is a receptor for attachment of envelope protein-free retrovirus-like particles and VSV-G pseudotyped MLV-derived retrovirus vectors to target cells. Mol Ther. 2002 May; 5(5 Pt 1):538-46. PMID: 11991744.
        View in: PubMed
      30. Friedmann T. Stanfield Rogers: insights into virus vectors and failure of an early gene therapy model. Mol Ther. 2001 Oct; 4(4):285-8. PMID: 11592829.
        View in: PubMed
      31. Friedmann T, Noguchi P, Mickelson C. The evolution of public review and oversight mechanisms in human gene transfer research: joint roles of the FDA and NIH. Curr Opin Biotechnol. 2001 Jun; 12(3):304-7. PMID: 11404110.
        View in: PubMed
      32. Friedmann T, Koss JO. Gene transfer and athletics- an impending problem. Mol Ther. 2001 Jun; 3(6):819-20. PMID: 11407894.
        View in: PubMed
      33. Friedmann T. Medical ethics. Principles for human gene therapy studies. Science. 2000 Mar 24; 287(5461):2163-5. PMID: 10744537.
        View in: PubMed
      34. Friedmann T. Changing roles for academia and industry in genetics and gene therapy. Mol Ther. 2000 Jan; 1(1):9-11. PMID: 10933906.
        View in: PubMed
      35. Friedmann T. The road toward human gene therapy--a 25-year perspective. Ann Med. 1997 Dec; 29(6):575-7. PMID: 9562527.
        View in: PubMed
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