Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Tannishtha Reya

    SchoolUniversity of California, San Diego
    DepartmentPharmacology and Medicine
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    vCardDownload vCard
      Other Positions
      TitlePharmacology and Medicine

      Collapse Biography 
      Collapse Education and Training
      Williams CollegeB.A.Biology
      University of PennsylvaniaPh.D.Immunology
      University of California San FranciscoPost-Doctoral FellowshipImmunology
      Stanford UniversityPost-Doctoral FellowshipStem Cell Biology
      Collapse Awards and Honors
      2005The Presidential Early Career Award for Scientists and Engineers (PECASE, US Govt.)
      2007Leukemia and Lymphoma Society Scholar Award
      2008Richard E Weitzman Award (Endocrine Society)
      2009NIH Director's Pioneer Award
      2015NCI Outstanding Investigator Award

      Collapse Overview 
      Collapse Overview
      The primary goal of our lab is to understand the signaling pathways that regulate the choice between stem cell renewal and commitment, and define how the same signals are subverted in cancer. The lab has three primary areas of interest: analyzing the role of developmental signals in stem cells and cancer, defining mechanisms that initiate stem cell regeneration after injury and developing high-resolution imaging strategies to visualize the behavior of living stem cells during growth, regeneration, and can¬cer formation. These studies have implications not only for understanding the basic mechanisms that regulate normal and oncogenic self-renewal, but also for enhancing stem cell based therapies for human disease.

      Collapse Research 
      Collapse Research Activities and Funding
      Reprogramming human stem cells for blood cell generation
      CIRM DISC1-10074Jul 1, 2017 - Jun 30, 2018
      Role: Principal Investigator
      Reprogramming Transcriptional Circuitry to Control Pancreatic Cancer
      Stand Up to Cancer/AACR/CRUK/Lustgarten Jan 31, 2016 - Dec 31, 2018
      Role: Senior Investigator
      Molecular strategies for early detection and targeting of cancer
      NIH/NCI R35CA197699Aug 12, 2015 - Jul 31, 2022
      Role: Principal Investigator
      Musashi-mediated control of pancreatic cancer growth and progression
      NIH/NCI R01CA186043Feb 1, 2015 - Jan 31, 2020
      Role: Principal Investigator
      Molecular Determinants of Asymmetric Division
      NIH/NIDDK R01DK099335Apr 1, 2014 - Mar 31, 2018
      Role: Principal Investigator
      Imaging self-renewal and transformation in hematopoietic stem cells
      NIH/NCI DP1CA174422Sep 30, 2009 - Jul 31, 2014
      Role: Principal Investigator
      Imaging self-renewal and transformation in hematopoietic stem cells
      NIH DP1OD006430Sep 30, 2009 - Jul 31, 2014
      Role: Principal Investigator
      Imaging the stem cell niche in regeneration and cancer
      NIH/NHLBI R01HL097767Sep 5, 2009 - Jul 31, 2013
      Role: Principal Investigator
      Damage and regeneration in the hematopoietic system
      NIH/NIDDK R01DK072234May 15, 2006 - Apr 30, 2010
      Role: Principal Investigator
      Centers for Medical Countermeasures Against Radiation
      NIH U19AI067798Aug 31, 2005 - Jul 31, 2020
      Role: Co-Investigator
      Regulation of Hematopoietic Stem Cell Self-Renewal
      NIH/NIDDK R01DK063031Apr 1, 2003 - Jul 31, 2012
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T. CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. Cancer Cell. 2016 Nov 14; 30(5):792-805. PMID: 27908736.
        View in: PubMed
      2. Koechlein CS, Harris JR, Lee TK, Weeks J, Fox RG, Zimdahl B, Ito T, Blevins A, Jung SH, Chute JP, Chourasia A, Covert MW, Reya T. High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo. Nat Commun. 2016 Jul 18; 7:12169. PMID: 27425143; PMCID: PMC4960315.
      3. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. PMID: 27281208; PMCID: PMC4998062 [Available on 12/16/16].
      4. Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia. Cell Stem Cell. 2015 Aug 06; 17(2):152-164. PMID: 26212080; PMCID: PMC4664079.
      5. Bajaj J, Zimdahl B, Reya T. Fearful symmetry: subversion of asymmetric division in cancer development and progression. Cancer Res. 2015 Mar 01; 75(5):792-7. PMID: 25681272; PMCID: PMC4784538.
      6. Fox RG, Park FD, Koechlein CS, Kritzik M, Reya T. Musashi signaling in stem cells and cancer. Annu Rev Cell Dev Biol. 2015; 31:249-67. PMID: 26566113.
        View in: PubMed
      7. Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13870-5. PMID: 25189770; PMCID: PMC4183333.
      8. Lento W, Ito T, Zhao C, Harris JR, Huang W, Jiang C, Owzar K, Piryani S, Racioppi L, Chao N, Reya T. Loss of ß-catenin triggers oxidative stress and impairs hematopoietic regeneration. Genes Dev. 2014 May 01; 28(9):995-1004. PMID: 24788518; PMCID: PMC4018497.
      9. Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. Nat Genet. 2014 Mar; 46(3):245-52. PMID: 24487275; PMCID: PMC4267534.
      10. Lento W, Congdon K, Voermans C, Kritzik M, Reya T. Wnt signaling in normal and malignant hematopoiesis. Cold Spring Harb Perspect Biol. 2013 Feb 01; 5(2). PMID: 23378582; PMCID: PMC3552513.
      11. Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP. Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Cell Rep. 2012 Oct 25; 2(4):964-75. PMID: 23084748; PMCID: PMC3696585.
      12. Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chen M, Lefkowitz RJ, Reya T. ß-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12532-7. PMID: 22773819; PMCID: PMC3411976.
      13. Ito T, Zimdahl B, Reya T. aSIRTing control over cancer stem cells. Cancer Cell. 2012 Feb 14; 21(2):140-2. PMID: 22340585.
        View in: PubMed
      14. Reya T. Illuminating immune privilege--a role for regulatory T cells in preventing rejection. N Engl J Med. 2011 Sep 08; 365(10):956-7. PMID: 21899457.
        View in: PubMed
      15. Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature. 2010 Aug 05; 466(7307):765-8. PMID: 20639863; PMCID: PMC2918284.
      16. Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner D, Reya T, Liu JO, Epstein EH, Stevens DA, Beachy PA. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 2010 Apr 13; 17(4):388-99. PMID: 20385363; PMCID: PMC4039177.
      17. Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med. 2010 Apr; 16(4):475-82. PMID: 20305662; PMCID: PMC3689427.
      18. Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA, Reya T. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 2009 Apr 09; 458(7239):776-9. PMID: 19169242; PMCID: PMC2946231.
      19. Kurokawa M, Zhao C, Reya T, Kornbluth S. Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias. Mol Cell Biol. 2008 Sep; 28(17):5494-506. PMID: 18591256; PMCID: PMC2519729.
      20. Congdon KL, Reya T. Divide and conquer: how asymmetric division shapes cell fate in the hematopoietic system. Curr Opin Immunol. 2008 Jun; 20(3):302-7. PMID: 18554882; PMCID: PMC2560983.
      21. Congdon KL, Voermans C, Ferguson EC, DiMascio LN, Uqoezwa M, Zhao C, Reya T. Activation of Wnt signaling in hematopoietic regeneration. Stem Cells. 2008 May; 26(5):1202-10. PMID: 18308947.
        View in: PubMed
      22. Zhao C, Blum J, Chen A, Kwon HY, Jung SH, Cook JM, Lagoo A, Reya T. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell. 2007 Dec; 12(6):528-41. PMID: 18068630; PMCID: PMC2262869.
      23. Wu M, Kwon HY, Rattis F, Blum J, Zhao C, Ashkenazi R, Jackson TL, Gaiano N, Oliver T, Reya T. Imaging hematopoietic precursor division in real time. Cell Stem Cell. 2007 Nov; 1(5):541-54. PMID: 18345353; PMCID: PMC2267762.
      24. Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol. 2007 Jun; 27(12):4328-39. PMID: 17371841; PMCID: PMC1900055.
      25. Kitsos CM, Sankar U, Illario M, Colomer-Font JM, Duncan AW, Ribar TJ, Reya T, Means AR. Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. J Biol Chem. 2005 Sep 30; 280(39):33101-8. PMID: 16020540.
        View in: PubMed
      26. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature. 2005 Apr 14; 434(7035):843-50. PMID: 15829953.
        View in: PubMed
      27. Duncan AW, Rattis FM, DiMascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, Reya T. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005 Mar; 6(3):314-22. PMID: 15665828.
        View in: PubMed
      28. Ranheim EA, Kwan HC, Reya T, Wang YK, Weissman IL, Francke U. Frizzled 9 knock-out mice have abnormal B-cell development. Blood. 2005 Mar 15; 105(6):2487-94. PMID: 15572594.
        View in: PubMed
      29. Pazianos G, Uqoezwa M, Reya T. The elements of stem cell self-renewal: a genetic perspective. Biotechniques. 2003 Dec; 35(6):1240-7. PMID: 14682059.
        View in: PubMed
      30. Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R, Weissman IL. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003 May 22; 423(6938):409-14. PMID: 12717450.
        View in: PubMed
      31. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR, Nusse R. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature. 2003 May 22; 423(6938):448-52. PMID: 12717451.
        View in: PubMed
      32. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001 Nov 01; 414(6859):105-11. PMID: 11689955.
        View in: PubMed
      Tannishtha's Networks
      Derived automatically from this person's publications.
      People in Profiles who have published with this person.
      Similar People
      People who share similar concepts with this person.
      Physical Neighbors
      People whose addresses are nearby this person.