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Tadeusz Molinski
Title
Adjunct Professor
School
University of California, San Diego
Department
Center for Marine Biotechnology and Biomedecine
Address
9500 Gilman Drive #0358
CA La Jolla 92093
Phone
858-534-7115
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Research
Research Activities and Funding
An Integrated Methodology for Nanomole-Scale Structure Elucidation of Natural Products
NIH/NCCIH
R21AT009783
Feb 1, 2018 - Jan 31, 2020
Role: Principal Investigator
Natural Products for Treatment of Emergent AIDS-Related Pathogens
NIH/NIAID
R01AI100776
Mar 15, 2012 - Feb 28, 2017
Role: Principal Investigator
Acquisition of a High Resolution TOF Mass Spectrometer
NIH/NCRR
S10RR025636
Apr 22, 2010 - Apr 21, 2011
Role: Principal Investigator
Nanoscale-Natural Products Chemistry
NIH/NCI
R01CA122256
Jul 22, 2006 - Jun 30, 2011
Role: Principal Investigator
Antifungal sphingolipids for AIDS-related Mycoses
NIH/FIC
R03TW006301
Apr 1, 2003 - Mar 31, 2006
Role: Principal Investigator
Natural Product Antitumor Inducers of Apoptosis
NIH/NCI
R01CA085602
Sep 6, 2002 - Aug 31, 2006
Role: Principal Investigator
ACQUISITION OF A QUADRUPOLE ION TRAP-HPLC
NIH/NCRR
S10RR014701
Mar 1, 2000 - Feb 28, 2001
Role: Principal Investigator
NOVEL PROBES FOR IMMUNOPHILIN MEDIATED CELL CONTROL
NIH/NIGMS
R01GM057560
May 1, 1998 - Apr 30, 2003
Role: Principal Investigator
Antifungals from Marine Invertebrates--AIDS Adjuvants
NIH/NIAID
R01AI039987
Mar 1, 1997 - Aug 31, 2012
Role: Principal Investigator
ANTIFUNGALS FROM MARINE INVERTEBRATES--AIDS ADJUVANTS
NIH/NIAID
R21AI039987
Sep 1, 1996 - Aug 31, 1997
Role: Principal Investigator
MECHANISM-SELECTIVE ANTIFUNGALS--POTENTIAL AIDS ADJUVANT
NIH/NIAID
R29AI031660
Sep 30, 1991 - Nov 30, 1997
Role: Principal Investigator
Bibliographic
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can
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Salib MN,
Molinski T
. Cyclic Hexapeptide Dimers, Antatollamides A and B, from the Ascidian Didemnum molle. A Tryptophan-Derived Auxiliary for l- and d-Amino Acid Assignments. J Org Chem. 2017 Sep 18. PMID: 28846849.
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PubMed
Saurí J, Reibarkh M, Zhang T, Cohen RD, Wang X,
Molinski T
, Martin GE, Williamson RT. Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of 35,37Cl Isotope Effects for 13C Nuclei. Org Lett. 2016 Oct 07; 18(19):4786-4789. PMID: 27681329.
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PubMed
Jamison MT, Macho J,
Molinski T
. Structure-activity of antifungal compounds inspired by aminobisabolenes from the sponge Halichondria sp. Bioorg Med Chem Lett. 2016 Nov 01; 26(21):5244-5246. PMID: 27720294.
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PubMed
Jamison MT,
Molinski T
. Jamaicensamide A, a Peptide Containing ß-Amino-a-keto and Thiazole-Homologated ?-Amino Acid Residues from the Sponge Plakina jamaicensis. J Nat Prod. 2016 Sep 23; 79(9):2243-9. PMID: 27547840.
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PubMed
Wang X, Duggan BM,
Molinski T
. Ultra-high resolution band-selective HSQC for nanomole-scale identification of chlorine-substituted 13 C in natural products drug discovery. Magn Reson Chem. 2017 Apr; 55(4):263-268. PMID: 26951950.
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PubMed
Jamison MT, Dalisay DS,
Molinski T
. Peroxide Natural Products from Plakortis zyggompha and the Sponge Association Plakortis halichondrioides-Xestospongia deweerdtae: Antifungal Activity against Cryptococcus gattii. J Nat Prod. 2016 Mar 25; 79(3):555-63. PMID: 26859086.
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PubMed
Wang X, Duggan BM,
Molinski T
. Mollenynes B-E from the marine sponge Spirastrella mollis. Band-selective heteronuclear single quantum coherence for discrimination of bromo-chloro regioisomerism in natural products. J Am Chem Soc. 2015 Sep 30; 137(38):12343-51. PMID: 26336030.
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PubMed
Jamison MT,
Molinski T
. Antipodal crambescin A2 homologues from the marine sponge Pseudaxinella reticulata. Antifungal structure-activity relationships. J Nat Prod. 2015 Mar 27; 78(3):557-61. PMID: 25738226.
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PubMed
Biegelmeyer R, Schröder R, Rambo DF, Dresch RR, Stout EP, Carraro JL, Mothes B, Moreira JC,
Molinski T
, da Frota Junior ML, Henriques AT. Cytotoxic effects on tumour cell lines of fatty acids from the marine sponge Scopalina ruetzleri. J Pharm Pharmacol. 2015 May; 67(5):746-53. PMID: 25560902.
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PubMed
Jamison MT, Boddy CN,
Molinski T
. Salvadenosine, a 5'-deoxy-5'-(methylthio) nucleoside from the Bahamian tunicate Didemnum sp. J Org Chem. 2014 Nov 07; 79(21):9992-7. PMID: 25284474; PMCID: PMC4227578.
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PubMed
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PubMed Central
Molinski T
. All natural: the renaissance of natural products chemistry. Org Lett. 2014 Aug 01; 16(15):3849-55. PMID: 25081565.
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PubMed
Molinski T
. All natural: the renaissance of natural products chemistry. J Org Chem. 2014 Aug 01; 79(15):6765. PMID: 25081028.
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PubMed
Stout EP, Choi MY, Castro JE,
Molinski T
. Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: design, synthesis, and pharmacokinetic studies. J Med Chem. 2014 Jun 26; 57(12):5085-93. PMID: 24673739; PMCID: PMC4079331.
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PubMed
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PubMed Central
Wang X, Morinaka BI,
Molinski T
. Structures and solution conformational dynamics of stylissamides G and H from the Bahamian sponge Stylissa caribica. J Nat Prod. 2014 Mar 28; 77(3):625-30. PMID: 24576291; PMCID: PMC3993948.
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PubMed
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PubMed Central
Januar LA,
Molinski T
. Acremolin from Acremonium strictum is N(2),3-etheno-2'-isopropyl-1-methylguanine, not a 1H-azirine. Synthesis and structural revision. Org Lett. 2013 May 17; 15(10):2370-3. PMID: 23635003; PMCID: PMC3957326.
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PubMed
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PubMed Central
Widom JR, Lee W, Perdomo-Ortiz A, Rappoport D,
Molinski T
, Aspuru-Guzik A, Marcus AH. Temperature-dependent conformations of a membrane supported zinc porphyrin tweezer by 2D fluorescence spectroscopy. J Phys Chem A. 2013 Jul 25; 117(29):6171-84. PMID: 23480874; PMCID: PMC3723700.
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PubMed
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PubMed Central
Ko J,
Molinski T
. D-Glucosamine-derived synthons for assembly of L-threo-sphingoid bases. Total synthesis of rhizochalinin C. J Org Chem. 2013 Jan 18; 78(2):498-505. PMID: 23227909; PMCID: PMC3548972.
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PubMed
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PubMed Central
Molinski T
, Biegelmeyer R, Stout EP, Wang X, Frota ML, Henriques AT. Halisphingosines A and B, modified sphingoid bases from Haliclona tubifera. Assignment of configuration by circular dichroism and van't Hoff's principle of optical superposition. J Nat Prod. 2013 Mar 22; 76(3):374-81. PMID: 23268569; PMCID: PMC3969749.
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PubMed
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PubMed Central
Molinski T
, Morinaka BI. INTEGRATED APPROACHES TO THE CONFIGURATIONAL ASSIGNMENT OF MARINE NATURAL PRODUCTS. Tetrahedron. 2012 Nov 18; 68(46):9307-9343. PMID: 23814320.
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PubMed
Stout EP, Yu LC,
Molinski T
. Antifungal Diterpene Alkaloids from the Caribbean Sponge Agelas citrina: Unified Configurational Assignments of Agelasidines and Agelasines. European J Org Chem. 2012 Sep; 2012(27):5131-5135. PMID: 24653665.
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PubMed
Altamirano F, López JR, Henríquez C,
Molinski T
, Allen PD, Jaimovich E. Increased resting intracellular calcium modulates NF-?B-dependent inducible nitric-oxide synthase gene expression in dystrophic mdx skeletal myotubes. J Biol Chem. 2012 Jun 15; 287(25):20876-87. PMID: 22549782; PMCID: PMC3375511.
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PubMed
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PubMed Central
Eltit JM, Bannister RA, Moua O, Altamirano F, Hopkins PM, Pessah IN,
Molinski T
, López JR, Beam KG, Allen PD. Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7923-8. PMID: 22547813; PMCID: PMC3356662.
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PubMed
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PubMed Central
Stout EP, Wang YG, Romo D,
Molinski T
. Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica. Angew Chem Int Ed Engl. 2012 May 14; 51(20):4877-81. PMID: 22473581; PMCID: PMC3917718.
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PubMed
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PubMed Central
Stout EP, Morinaka BI, Wang YG, Romo D,
Molinski T
. De novo synthesis of benzosceptrin C and nagelamide H from 7-15N-oroidin: implications for pyrrole-aminoimidazole alkaloid biosynthesis. J Nat Prod. 2012 Apr 27; 75(4):527-30. PMID: 22455452; PMCID: PMC3694594.
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PubMed
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PubMed Central
Molinski T
, Reynolds KA, Morinaka BI. Symplocin A, a linear peptide from the Bahamian cyanobacterium Symploca sp. Configurational analysis of N,N-dimethylamino acids by chiral-phase HPLC of naphthacyl esters. J Nat Prod. 2012 Mar 23; 75(3):425-31. PMID: 22360587; PMCID: PMC3694611.
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PubMed
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PubMed Central
Morinaka BI,
Molinski T
. Mollenyne A, a long-chain chlorodibromohydrin amide from the sponge Spirastrella mollis. Org Lett. 2011 Dec 16; 13(24):6338-41. PMID: 22087509; PMCID: PMC3544366.
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PubMed
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PubMed Central
Flores B,
Molinski T
. Assembly of the isoindolinone core of muironolide A by asymmetric intramolecular Diels-Alder cycloaddition. Org Lett. 2011 Aug 05; 13(15):3932-5. PMID: 21751773; PMCID: PMC4000739.
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PubMed
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PubMed Central
Liu C,
Molinski T
. Preparation of a-amino acids by oxidative oxazoline-oxazinone rearrangement-hydrogenation (OOOH). Scope and limitations. Chem Asian J. 2011 Aug 01; 6(8):2022-7. PMID: 21751407.
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PubMed
Smith AB, Hogan AM, Liu Z, Razler TM, Meis RM, Morinaka BI,
Molinski T
. Phorboxazole Synthetic Studies: Design, Synthesis and Biological Evaluation of Phorboxazole A and Hemi-Phorboxazole A Related Analogues. Tetrahedron. 2011 Jul 08; 67(27-28):5069-5078. PMID: 21811346.
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PubMed
Dalisay DS, Saludes JP,
Molinski T
. Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans. Bioorg Med Chem. 2011 Nov 15; 19(22):6654-7. PMID: 21715177; PMCID: PMC3523195.
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PubMed
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PubMed Central
Eltit JM, Li H, Ward CW,
Molinski T
, Pessah IN, Allen PD, Lopez JR. Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):7046-51. PMID: 21482776; PMCID: PMC3084091.
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PubMed
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PubMed Central
Morinaka BI,
Molinski T
. Xestoproxamines A-C from Neopetrosia proxima. Assignment of absolute stereostructure of bis-piperidine alkaloids by integrated degradation-CD analysis. J Nat Prod. 2011 Mar 25; 74(3):430-40. PMID: 21341726; PMCID: PMC3957325.
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PubMed
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PubMed Central
Molinski T
, Ko J, Reynolds KA, Lievens SC, Skarda KR. N,N'-methyleno-didemnin A from the ascidian Trididemnum solidum. Complete NMR assignments and confirmation of the imidazolidinone ring by strategic analysis of 1J(CH). J Nat Prod. 2011 Apr 25; 74(4):882-7. PMID: 21341712; PMCID: PMC3694603.
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PubMed
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PubMed Central
Ko J, Morinaka BI,
Molinski T
. Faulknerynes A-C from a Bahamian sponge Diplastrella sp.: stereoassignment by critical application of two exciton coupled CD methods. J Org Chem. 2011 Feb 04; 76(3):894-901. PMID: 21218782; PMCID: PMC3523196.
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PubMed
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PubMed Central
Eltit JM, Feng W, Lopez JR, Padilla IT, Pessah IN,
Molinski T
, Fruen BR, Allen PD, Perez CF. Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+. J Biol Chem. 2010 Dec 03; 285(49):38453-62. PMID: 20926377; PMCID: PMC2992278.
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PubMed
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PubMed Central
Molinski T
. Microscale methodology for structure elucidation of natural products. Curr Opin Biotechnol. 2010 Dec; 21(6):819-26. PMID: 20880694; PMCID: PMC2982861.
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PubMed
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PubMed Central
Skepper CK, Quach T,
Molinski T
. Total synthesis of enigmazole A from Cinachyrella enigmatica. Bidirectional bond constructions with an ambident 2,4-disubstituted oxazole synthon. J Am Chem Soc. 2010 Aug 04; 132(30):10286-92. PMID: 20590095.
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PubMed
Dalisay DS,
Molinski T
. Structure elucidation at the nanomole scale. 3. Phorbasides G-I from Phorbas sp. J Nat Prod. 2010 Apr 23; 73(4):679-82. PMID: 20184337; PMCID: PMC2859111.
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PubMed
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PubMed Central
Morinaka BI, Pawlik JR,
Molinski T
. Amaranzoles B-F, imidazole-2-carboxy steroids from the marine sponge Phorbas amaranthus. C24-N- and C24-O-analogues from a divergent oxidative biosynthesis. J Org Chem. 2010 Apr 16; 75(8):2453-60. PMID: 20235564; PMCID: PMC2852487.
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PubMed
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PubMed Central
Dalisay DS, Quach T,
Molinski T
. Liposomal circular dichroism. Assignment of remote stereocenters in plakinic acids K and L from a Plakortis-Xestospongia sponge association. Org Lett. 2010 Apr 02; 12(7):1524-7. PMID: 20205426; PMCID: PMC2846192.
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PubMed
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PubMed Central
Wang YG, Morinaka BI, Reyes JC, Wolff JJ, Romo D,
Molinski T
. Synthesis of 7-(15)N-Oroidin and evaluation of utility for biosynthetic studies of pyrrole-imidazole alkaloids by microscale (1)H-(15)N HSQC and FTMS. J Nat Prod. 2010 Mar 26; 73(3):428-34. PMID: 20095632; PMCID: PMC3544367.
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PubMed
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PubMed Central
Pigza JA,
Molinski T
. Diastereoselective allylstannane additions to (S)-5,6-dihydro-2H-5-phenyloxazin-2-one. A concise synthesis of (S)-beta-methylisoleucine. Org Lett. 2010 Mar 19; 12(6):1256-9. PMID: 20163126; PMCID: PMC2837769.
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PubMed
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PubMed Central
Eltit JM, Yang T, Li H,
Molinski T
, Pessah IN, Allen PD, Lopez JR. RyR1-mediated Ca2+ leak and Ca2+ entry determine resting intracellular Ca2+ in skeletal myotubes. J Biol Chem. 2010 Apr 30; 285(18):13781-7. PMID: 20207743; PMCID: PMC2859541.
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PubMed
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PubMed Central
Rogers EW, Dalisay DS,
Molinski T
. Zwittermicin A: synthesis of analogs and structure-activity studies. Bioorg Med Chem Lett. 2010 Apr 01; 20(7):2183-5. PMID: 20189808; PMCID: PMC2845154.
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PubMed
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PubMed Central
Molinski T
. NMR of natural products at the 'nanomole-scale'. Nat Prod Rep. 2010 Mar; 27(3):321-9. PMID: 20179874.
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PubMed
Skepper CK, Dalisay DS,
Molinski T
. Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine. Bioorg Med Chem Lett. 2010 Mar 15; 20(6):2029-32. PMID: 20171099; PMCID: PMC2834865.
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PubMed
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PubMed Central
Makarieva TN, Zakharenko AM, Dmitrenok PS, Guzii AG, Denisenko VA, Savina AS, Dalisay DS,
Molinski T
, Stonik VA. Isorhizochalin: a minor unprecedented bipolar sphingolipid of stereodivergent biogenesis from the Rhizochalina incrustata. Lipids. 2009 Dec; 44(12):1155-62. PMID: 19882184.
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PubMed
Rogers EW,
Molinski T
. (+)-Zwittermicin A. Rapid assembly of C9-C15 and a formal total synthesis. J Org Chem. 2009 Oct 16; 74(20):7660-4. PMID: 19746943; PMCID: PMC2759841.
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PubMed
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PubMed Central
Smith AB, Liu Z, Hogan AM, Dalisay DS,
Molinski T
. Hemi-phorboxazole a: structure confirmation, analogue design and biological evaluation. Org Lett. 2009 Aug 20; 11(16):3766-9. PMID: 19637861; PMCID: PMC2743491.
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PubMed
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PubMed Central
Pigza JA, Quach T,
Molinski T
. Oxazoline-oxazinone oxidative rearrangement. divergent syntheses of (2S,3S)-4,4,4-trifluorovaline and (2S,4S)-5,5,5-Trifluoroleucine. J Org Chem. 2009 Aug 07; 74(15):5510-5. PMID: 19537688.
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PubMed
Dalisay DS, Morinaka BI, Skepper CK,
Molinski T
. A tetrachloro polyketide hexahydro-1H-isoindolone, muironolide A, from the marine sponge Phorbas sp. natural products at the nanomole scale. J Am Chem Soc. 2009 Jun 10; 131(22):7552-3. PMID: 19453148.
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PubMed
Molinski T
. Marine natural products. Clin Adv Hematol Oncol. 2009 Jun; 7(6):383-5. PMID: 19606073.
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PubMed
Dalisay DS,
Molinski T
. Structure elucidation at the nanomole scale. 2. Hemi-phorboxazole A from Phorbas sp. Org Lett. 2009 May 07; 11(9):1967-70. PMID: 19341267.
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PubMed
Mulder RJ, Shafer CM, Dalisay DS,
Molinski T
. Synthesis and structure-activity relationships of bengazole A analogs. Bioorg Med Chem Lett. 2009 Jun 01; 19(11):2928-30. PMID: 19419860; PMCID: PMC2691865.
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PubMed
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PubMed Central
Dalisay DS,
Molinski T
. NMR quantitation of natural products at the nanomole scale. J Nat Prod. 2009 Apr; 72(4):739-44. PMID: 19399996; PMCID: PMC2753506.
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PubMed
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PubMed Central
Dalisay DS, Rogers EW, Edison AS,
Molinski T
. Structure elucidation at the nanomole scale. 1. Trisoxazole macrolides and thiazole-containing cyclic peptides from the nudibranch Hexabranchus sanguineus. J Nat Prod. 2009 Apr; 72(4):732-8. PMID: 19254038; PMCID: PMC2753413.
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PubMed
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PubMed Central
Dalisay DS, Tsukamoto S,
Molinski T
. Absolute configuration of the alpha,omega-bifunctionalized sphingolipid leucettamol A from Leucetta microrhaphis by deconvoluted exciton coupled CD. J Nat Prod. 2009 Mar 27; 72(3):353-9. PMID: 19159253; PMCID: PMC2765480.
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PubMed Central
Molinski T
. Nanomole-scale natural products discovery. Curr Opin Drug Discov Devel. 2009 Mar; 12(2):197-206. PMID: 19333865.
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PubMed
Morinaka BI, Pawlik JR,
Molinski T
. Amaroxocanes A and B: sulfated dimeric sterols defend the Caribbean coral reef sponge Phorbas amaranthus from fish predators. J Nat Prod. 2009 Feb 27; 72(2):259-64. PMID: 19143510.
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PubMed
Dalisay DS, Quach T, Nicholas GN,
Molinski T
. Amplification of the Cotton effect of a single chromophore through liposomal ordering-stereochemical assignment of plakinic acids I and J. Angew Chem Int Ed Engl. 2009; 48(24):4367-71. PMID: 19437515; PMCID: PMC2872062.
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PubMed
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PubMed Central
Molinski T
, Dalisay DS, Lievens SL, Saludes JP. Drug development from marine natural products. Nat Rev Drug Discov. 2009 Jan; 8(1):69-85. PMID: 19096380.
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PubMed
Skepper CK, Dalisay DS,
Molinski T
. Synthesis and antifungal activity of (-)-(Z)-dysidazirine. Org Lett. 2008 Nov 20; 10(22):5269-71. PMID: 18937483; PMCID: PMC2635126.
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PubMed
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PubMed Central
Morinaka BI,
Molinski T
. Exciton coupling circular dichroism of an allylic N-imidazolyl group in amaranzole A, a marine natural product from Phorbas amaranthus. Chirality. 2008 Sep; 20(9):1066-70. PMID: 18690668; PMCID: PMC2615005.
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PubMed Central
MacMillan JB, Xiong-Zhou G, Skepper CK,
Molinski T
. Phorbasides A-E, cytotoxic chlorocyclopropane macrolide glycosides from the marine sponge Phorbas sp. CD determination of C-methyl sugar configurations. J Org Chem. 2008 May 16; 73(10):3699-706. PMID: 18412387.
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PubMed
Skepper CK,
Molinski T
. Long-chain 2H-azirines with heterogeneous terminal halogenation from the marine sponge Dysidea fragilis. J Org Chem. 2008 Apr 04; 73(7):2592-7. PMID: 18321120.
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PubMed
Dadsetan S, Zakharova L,
Molinski T
, Fomina AF. Store-operated Ca2+ influx causes Ca2+ release from the intracellular Ca2+ channels that is required for T cell activation. J Biol Chem. 2008 May 02; 283(18):12512-9. PMID: 18316371.
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PubMed
Rogers EW, Dalisay DS,
Molinski T
. (+)-Zwittermicin A: assignment of its complete configuration by total synthesis of the enantiomer and implication of D-serine in its biosynthesis. Angew Chem Int Ed Engl. 2008; 47(42):8086-9. PMID: 18798190; PMCID: PMC3957322.
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PubMed
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PubMed Central
Makarieva TN, Dmitrenok PS, Zakharenko AM, Denisenko VA, Guzii AG, Li R, Skepper CK,
Molinski T
, Stonik VA. Rhizochalins C and D from the sponge Rhizochalina incrustata. A rare threo-sphingolipid and a facile method for determination of the carbonyl position in alpha,omega-bifunctionalized ketosphingolipids. J Nat Prod. 2007 Dec; 70(12):1991-8. PMID: 18052325.
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PubMed
Schuetz A, Junker J, Leonov A, Lange OF,
Molinski T
, Griesinger C. Stereochemistry of sagittamide A from residual dipolar coupling enhanced NMR. J Am Chem Soc. 2007 Dec 12; 129(49):15114-5. PMID: 17999506.
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PubMed
Morinaka BI, Masuno MN, Pawlik JR,
Molinski T
. Amaranzole A, a new N-imidazolyl steroid from Phorbas amaranthus. Org Lett. 2007 Dec 06; 9(25):5219-22. PMID: 17990891.
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PubMed
Rogers EW,
Molinski T
. Highly polar spiroisoxazolines from the sponge Aplysina fulva. J Nat Prod. 2007 Jul; 70(7):1191-4. PMID: 17579462; PMCID: PMC2533261.
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Morinaka BI, Skepper CK,
Molinski T
. Ene-yne tetrahydrofurans from the sponge Xestospongia muta. exploiting a weak CD effect for assignment of configuration. Org Lett. 2007 May 10; 9(10):1975-8. PMID: 17439137.
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PubMed
Skepper CK, Macmillan JB, Zhou GX, Masuno MN,
Molinski T
. Chlorocyclopropane macrolides from the marine sponge Phorbas sp. assignment of the configurations of phorbasides A and B by quantitative CD. J Am Chem Soc. 2007 Apr 11; 129(14):4150-1. PMID: 17373800.
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PubMed
Saludes JP, Lievens SC,
Molinski T
. Occurrence of the alpha-glucosidase inhibitor 1,4-Dideoxy-1,4-imino-D-arabinitol and related iminopentitols in marine sponges. J Nat Prod. 2007 Mar; 70(3):436-8. PMID: 17378534.
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PubMed
Rogers EW,
Molinski T
. Asymmetric synthesis of diastereomeric diaminoheptanetetraols. A proposal for the configuration of (+)-zwittermicin a. Org Lett. 2007 Feb 01; 9(3):437-40. PMID: 17249781; PMCID: PMC2729442.
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PubMed Central
Yang T, Esteve E, Pessah IN,
Molinski T
, Allen PD, López JR. Elevated resting [Ca(2+)](i) in myotubes expressing malignant hyperthermia RyR1 cDNAs is partially restored by modulation of passive calcium leak from the SR. Am J Physiol Cell Physiol. 2007 May; 292(5):C1591-8. PMID: 17182726.
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PubMed
Lievens SC,
Molinski T
. Progressive-convergent elucidation of stereochemistry in complex polyols. The absolute configuration of (-)-sagittamide A. J Am Chem Soc. 2006 Sep 13; 128(36):11764-5. PMID: 16953609; PMCID: PMC3340292.
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Masuno MN, Pessah IN, Olmstead MM,
Molinski T
. Simplified cyclic analogues of bastadin-5. Structure-activity relationships for modulation of the RyR1/FKBP12 Ca2+ channel complex. J Med Chem. 2006 Jul 27; 49(15):4497-511. PMID: 16854055; PMCID: PMC3987770.
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PubMed Central
Linington RG, Robertson M, Gauthier A, Finlay BB, MacMillan JB,
Molinski T
, van Soest R, Andersen RJ. Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia. J Nat Prod. 2006 Feb; 69(2):173-7. PMID: 16499312.
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Zhou GX,
Molinski T
. Manoalide derivatives from a sponge, Luffariella sp. J Asian Nat Prod Res. 2006 Jan-Mar; 8(1-2):15-20. PMID: 16753777.
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Ta TA, Feng W,
Molinski T
, Pessah IN. Hydroxylated xestospongins block inositol-1,4,5-trisphosphate-induced Ca2+ release and sensitize Ca2+-induced Ca2+ release mediated by ryanodine receptors. Mol Pharmacol. 2006 Feb; 69(2):532-8. PMID: 16249374.
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Makarieva TN, Denisenko VA, Dmitrenok PS, Guzii AG, Santalova EA, Stonik VA, Macmillan JB,
Molinski T
. Oceanalin A, a hybrid alpha,omega-bifunctionalized sphingoid tetrahydroisoquinoline beta-glycoside from the marine sponge Oceanapia sp. Org Lett. 2005 Jul 07; 7(14):2897-900. PMID: 15987164.
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Rogers EW, de Oliveira MF, Berlinck RG, König GM,
Molinski T
. Stereochemical heterogeneity in Verongid sponge metabolites. Absolute stereochemistry of (+)-fistularin-3 and (+)-11-epi-fistularin-3 by microscale LCMS-Marfey's analysis. J Nat Prod. 2005 Jun; 68(6):891-6. PMID: 15974614.
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Lievens SC,
Molinski T
. Sagittamides A and B. Polyacetoxy long-chain acyl amino acids from a didemnid ascidian. Org Lett. 2005 May 26; 7(11):2281-4. PMID: 15901189.
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Masuno MN, Young DM, Hoepker AC, Skepper CK,
Molinski T
. Addition of Cl2C: to (-)-O-menthyl acrylate under sonication-phase-transfer catalysis. Efficient synthesis of (+)- and (-)-(2-chlorocyclopropyl)methanol. J Org Chem. 2005 May 13; 70(10):4162-5. PMID: 15876110.
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Macmillan JB,
Molinski T
. Majusculoic acid, a brominated cyclopropyl fatty acid from a marine cyanobacterial mat assemblage. J Nat Prod. 2005 Apr; 68(4):604-6. PMID: 15844960.
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Rogers EW,
Molinski T
. A cytotoxic carotenoid from the marine sponge Prianos osiros. J Nat Prod. 2005 Mar; 68(3):450-2. PMID: 15787458.
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Makarieva TN, Guzii AG, Denisenko VA, Dmitrenok PS, Santalova EA, Pokanevich EV,
Molinski T
, Stonik VA. Rhizochalin A, a novel two-headed sphingolipid from the sponge Rhizochalina incrustata. J Nat Prod. 2005 Feb; 68(2):255-7. PMID: 15730256.
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Lievens SC, Hope H,
Molinski T
. New 3-oxo-chol-4-en-24-oic acids from the marine soft coral Eleutherobia sp. J Nat Prod. 2004 Dec; 67(12):2130-2. PMID: 15620271.
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Grubb CD, Zipp BJ, Ludwig-Müller J, Masuno MN,
Molinski T
, Abel S. Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis. Plant J. 2004 Dec; 40(6):893-908. PMID: 15584955.
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Liu C, Masuno MN, Macmillan JB,
Molinski T
. Enantioselective total synthesis of (+)-milnamide A and evidence of its autoxidation to (+)-milnamide D. Angew Chem Int Ed Engl. 2004 Nov 12; 43(44):5951-4. PMID: 15547903.
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Macmillan JB, Linington RG, Andersen RJ,
Molinski T
. Stereochemical assignment in acyclic lipids across long distance by circular dichroism: absolute stereochemistry of the aglycone of caminoside A. Angew Chem Int Ed Engl. 2004 Nov 12; 43(44):5946-51. PMID: 15547902.
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Kossuga MH, MacMillan JB, Rogers EW,
Molinski T
, Nascimento GG, Rocha RM, Berlinck RG. (2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga. J Nat Prod. 2004 Nov; 67(11):1879-81. PMID: 15568780.
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MacMillan JB,
Molinski T
. Long-range stereo-relay: relative and absolute configuration of 1,n-glycols from circular dichroism of liposomal porphyrin esters. J Am Chem Soc. 2004 Aug 18; 126(32):9944-5. PMID: 15303868.
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Andersen RJ, Ireland CM,
Molinski T
, Bewley CA. Research achievement award--D. John Faulkner. J Nat Prod. 2004 Aug; 67(8):1239-51. PMID: 15332836.
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Masuno MN, Pawlik JR,
Molinski T
. Phorbasterones A-D, cytotoxic nor-ring A steroids from the sponge Phorbas amaranthus. J Nat Prod. 2004 Apr; 67(4):731-3. PMID: 15104518.
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Richter RK, Mickus DE, Rychnovsky SD,
Molinski T
. Differential modulation of the antifungal activity of amphotericin B by natural and ent-cholesterol. Bioorg Med Chem Lett. 2004 Jan 05; 14(1):115-8. PMID: 14684310.
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Masuno MN,
Molinski T
. Cationic reduction of bastadin-4 to bastadin-5. Preparation of 5-[2h]-bastadin-5 by site-specific isotopic labeling. J Nat Prod. 2003 Jan; 66(1):112-4. PMID: 12542356.
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MacMillan JB, Ernst-Russell MA, de Ropp JS,
Molinski T
. Lobocyclamides A-C, lipopeptides from a cryptic cyanobacterial mat containing Lyngbya confervoides. J Org Chem. 2002 Nov 15; 67(23):8210-5. PMID: 12423153.
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Nicholas GM, Li R, MacMillan JB,
Molinski T
. Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols. Bioorg Med Chem Lett. 2002 Aug 19; 12(16):2159-62. PMID: 12127527.
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MacMillan JB,
Molinski T
. Lobocyclamide B from Lyngbya confervoides. Configuration and asymmetric synthesis of beta-hydroxy-alpha-amino acids by (-)-sparteine-mediated aldol addition. Org Lett. 2002 May 30; 4(11):1883-6. PMID: 12027638.
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MacMillan JB,
Molinski T
. Caylobolide A, a unique 36-membered macrolactone from a Bahamian Lyngbya majuscula. Org Lett. 2002 May 02; 4(9):1535-8. PMID: 11975622.
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Moon SS, MacMillan JB, Olmstead MM, Ta TA, Pessah IN,
Molinski T
. (+)-7S-Hydroxyxestospongin A from the marine sponge Xestospongia sp. and absolute configuration of (+)-xestospongin D. J Nat Prod. 2002 Mar; 65(3):249-54. PMID: 11908959.
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Franz AH,
Molinski T
, Lebrilla CB. MALDI-FTMS characterization of oligosaccharides labeled with 9-aminofluorene. J Am Soc Mass Spectrom. 2001 Dec; 12(12):1254-61. PMID: 11766752.
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Haak LL, Song LS,
Molinski T
, Pessah IN, Cheng H, Russell JT. Sparks and puffs in oligodendrocyte progenitors: cross talk between ryanodine receptors and inositol trisphosphate receptors. J Neurosci. 2001 Jun 01; 21(11):3860-70. PMID: 11356874.
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MacMillan JB, Trousdale EK,
Molinski T
. Structure of (-)-neodysidenin from Dysidea herbacea. Implications for biosynthesis of 5,5,5-trichloroleucine peptides. Org Lett. 2000 Aug 24; 2(17):2721-3. PMID: 10990437.
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MacMillan JB,
Molinski T
. Herbacic acid, a simple prototype of 5,5,5-trichloroleucine metabolites from the sponge Dysidea herbacea. J Nat Prod. 2000 Jan; 63(1):155-7. PMID: 10650102.
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Nicholas GM, Hong TW,
Molinski T
, Lerch ML, Cancilla MT, Lebrilla CB. Oceanapiside, an antifungal bis-alpha,omega-amino alcohol glycoside from the marine sponge Oceanapia phillipensis. J Nat Prod. 1999 Dec; 62(12):1678-81. PMID: 10654417.
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Chen L,
Molinski T
, Pessah IN. Bastadin 10 stabilizes the open conformation of the ryanodine-sensitive Ca(2+) channel in an FKBP12-dependent manner. J Biol Chem. 1999 Nov 12; 274(46):32603-12. PMID: 10551814.
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Mulder RJ, Shafer CM,
Molinski T
. First Total Synthesis of Bengazole A. J Org Chem. 1999 Jun 25; 64(13):4995-4998. PMID: 11674590.
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Shafer CM,
Molinski T
. Practical synthesis of 2,6-dideoxy-D-lyxo-hexose ("2-deoxy-D-fucose") from D-galactose. Carbohydr Res. 1998 Aug; 310(4):223-8. PMID: 9821260.
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Shafer CM,
Molinski T
. Monosubstituted Oxazoles. 1. Synthesis of 5-Substituted Oxazoles by Directed Alkylation. J Org Chem. 1998 Feb 06; 63(3):551-555. PMID: 11672044.
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Hong TW, Jímenez DR,
Molinski T
. Agelastatins C and D, new pentacyclic bromopyrroles from the sponge Cymbastela sp., and potent arthropod toxicity of (-)-agelastatin A. J Nat Prod. 1998 Jan; 61(1):158-61. PMID: 9461668.
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Gafni J, Munsch JA, Lam TH, Catlin MC, Costa LG,
Molinski T
, Pessah IN. Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron. 1997 Sep; 19(3):723-33. PMID: 9331361.
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Pessah IN,
Molinski T
, Meloy TD, Wong P, Buck ED, Allen PD, Mohr FC, Mack MM. Bastadins relate ryanodine-sensitive and -insensitive Ca2+ efflux pathways in skeletal SR and BC3H1 cells. Am J Physiol. 1997 Feb; 272(2 Pt 1):C601-14. PMID: 9124304.
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Franklin MA, Penn SG, Lebrilla CB, Lam TH, Pessah IN,
Molinski T
. Bastadin 20 and bastadin O-sulfate esters from Ianthella basta: novel modulators of the Ry1R FKBP12 receptor complex. J Nat Prod. 1996 Dec; 59(12):1121-7. PMID: 8988595.
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Preston CM, Wu KY,
Molinski T
, DeLong EF. A psychrophilic crenarchaeon inhabits a marine sponge: Cenarchaeum symbiosum gen. nov., sp. nov. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6241-6. PMID: 8692799; PMCID: PMC39006.
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PubMed Central
Searle PA, Richter RK,
Molinski T
. Bengazoles C-G from the Sponge Jaspis sp. Synthesis of the Side Chain and Determination of Absolute Configuration. J Org Chem. 1996 Jun 14; 61(12):4073-4079. PMID: 11667285.
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Wu J, Fannin ST, Franklin MA,
Molinski T
, Lebrilla CB. Exact mass determination for elemental analysis of ions produced by matrix-assisted laser desorption. Anal Chem. 1995 Oct 15; 67(20):3788-92. PMID: 8644924.
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Searle PA,
Molinski T
. 4-Dehydroecdysterone, a new ecdysteroid from the zoanthid Parazoanthus sp. J Nat Prod. 1995 Feb; 58(2):264-8. PMID: 7769393.
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Mack MM,
Molinski T
, Buck ED, Pessah IN. Novel modulators of skeletal muscle FKBP12/calcium channel complex from Ianthella basta. Role of FKBP12 in channel gating. J Biol Chem. 1994 Sep 16; 269(37):23236-49. PMID: 8083229.
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Antonio J,
Molinski T
. Screening of marine invertebrates for the presence of ergosterol-sensitive antifungal compounds. J Nat Prod. 1993 Jan; 56(1):54-61. PMID: 8450321.
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Molinski T
. Developments in marine natural products. Receptor-specific bioactive compounds. J Nat Prod. 1993 Jan; 56(1):1-8. PMID: 8450313.
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Taylor SW,
Molinski T
, Rzepecki LM, Waite JH. Oxidation of peptidyl 3,4-dihydroxyphenylalanine analogues: implications for the biosynthesis of tunichromes and related oligopeptides. J Nat Prod. 1991 May-Jun; 54(3):918-22. PMID: 1955891.
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Macleod JK, Moeller PD,
Molinski T
, Koul O. Antifeedant activity againstSpodoptera litera larvae and [(13)C]NMR spectral assignments of the meliatoxins. J Chem Ecol. 1990 Aug; 16(8):2511-8. PMID: 24264216.
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Alkaloids
Antifungal Agents
Porifera
Oxazoles
Molecular Structure
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Castro, Januario
Duggan, Brendan
Choi, Michael
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