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    Tadeusz Molinski

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentCenter for Marine Biotechnology and Biomedecine
    Address9500 Gilman Drive #0358
    CA La Jolla 92093
    Phone858-534-7115
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      An Integrated Methodology for Nanomole-Scale Structure Elucidation of Natural Products
      NIH/NCCIH R21AT009783Feb 1, 2018 - Jan 31, 2020
      Role: Principal Investigator
      Natural Products for Treatment of Emergent AIDS-Related Pathogens
      NIH/NIAID R01AI100776Mar 15, 2012 - Feb 28, 2017
      Role: Principal Investigator
      Acquisition of a High Resolution TOF Mass Spectrometer
      NIH/NCRR S10RR025636Apr 22, 2010 - Apr 21, 2011
      Role: Principal Investigator
      Nanoscale-Natural Products Chemistry
      NIH/NCI R01CA122256Jul 22, 2006 - Jun 30, 2011
      Role: Principal Investigator
      Antifungal sphingolipids for AIDS-related Mycoses
      NIH/FIC R03TW006301Apr 1, 2003 - Mar 31, 2006
      Role: Principal Investigator
      Natural Product Antitumor Inducers of Apoptosis
      NIH/NCI R01CA085602Sep 6, 2002 - Aug 31, 2006
      Role: Principal Investigator
      ACQUISITION OF A QUADRUPOLE ION TRAP-HPLC
      NIH/NCRR S10RR014701Mar 1, 2000 - Feb 28, 2001
      Role: Principal Investigator
      NOVEL PROBES FOR IMMUNOPHILIN MEDIATED CELL CONTROL
      NIH/NIGMS R01GM057560May 1, 1998 - Apr 30, 2003
      Role: Principal Investigator
      Antifungals from Marine Invertebrates--AIDS Adjuvants
      NIH/NIAID R01AI039987Mar 1, 1997 - Aug 31, 2012
      Role: Principal Investigator
      ANTIFUNGALS FROM MARINE INVERTEBRATES--AIDS ADJUVANTS
      NIH/NIAID R21AI039987Sep 1, 1996 - Aug 31, 1997
      Role: Principal Investigator
      MECHANISM-SELECTIVE ANTIFUNGALS--POTENTIAL AIDS ADJUVANT
      NIH/NIAID R29AI031660Sep 30, 1991 - Nov 30, 1997
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Salib MN, Molinski T. Cyclic Hexapeptide Dimers, Antatollamides A and B, from the Ascidian Didemnum molle. A Tryptophan-Derived Auxiliary for l- and d-Amino Acid Assignments. J Org Chem. 2017 Sep 18. PMID: 28846849.
        View in: PubMed
      2. Saurí J, Reibarkh M, Zhang T, Cohen RD, Wang X, Molinski T, Martin GE, Williamson RT. Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of 35,37Cl Isotope Effects for 13C Nuclei. Org Lett. 2016 Oct 07; 18(19):4786-4789. PMID: 27681329.
        View in: PubMed
      3. Jamison MT, Macho J, Molinski T. Structure-activity of antifungal compounds inspired by aminobisabolenes from the sponge Halichondria sp. Bioorg Med Chem Lett. 2016 Nov 01; 26(21):5244-5246. PMID: 27720294.
        View in: PubMed
      4. Jamison MT, Molinski T. Jamaicensamide A, a Peptide Containing ß-Amino-a-keto and Thiazole-Homologated ?-Amino Acid Residues from the Sponge Plakina jamaicensis. J Nat Prod. 2016 Sep 23; 79(9):2243-9. PMID: 27547840.
        View in: PubMed
      5. Wang X, Duggan BM, Molinski T. Ultra-high resolution band-selective HSQC for nanomole-scale identification of chlorine-substituted 13 C in natural products drug discovery. Magn Reson Chem. 2017 Apr; 55(4):263-268. PMID: 26951950.
        View in: PubMed
      6. Jamison MT, Dalisay DS, Molinski T. Peroxide Natural Products from Plakortis zyggompha and the Sponge Association Plakortis halichondrioides-Xestospongia deweerdtae: Antifungal Activity against Cryptococcus gattii. J Nat Prod. 2016 Mar 25; 79(3):555-63. PMID: 26859086.
        View in: PubMed
      7. Wang X, Duggan BM, Molinski T. Mollenynes B-E from the marine sponge Spirastrella mollis. Band-selective heteronuclear single quantum coherence for discrimination of bromo-chloro regioisomerism in natural products. J Am Chem Soc. 2015 Sep 30; 137(38):12343-51. PMID: 26336030.
        View in: PubMed
      8. Jamison MT, Molinski T. Antipodal crambescin A2 homologues from the marine sponge Pseudaxinella reticulata. Antifungal structure-activity relationships. J Nat Prod. 2015 Mar 27; 78(3):557-61. PMID: 25738226.
        View in: PubMed
      9. Biegelmeyer R, Schröder R, Rambo DF, Dresch RR, Stout EP, Carraro JL, Mothes B, Moreira JC, Molinski T, da Frota Junior ML, Henriques AT. Cytotoxic effects on tumour cell lines of fatty acids from the marine sponge Scopalina ruetzleri. J Pharm Pharmacol. 2015 May; 67(5):746-53. PMID: 25560902.
        View in: PubMed
      10. Jamison MT, Boddy CN, Molinski T. Salvadenosine, a 5'-deoxy-5'-(methylthio) nucleoside from the Bahamian tunicate Didemnum sp. J Org Chem. 2014 Nov 07; 79(21):9992-7. PMID: 25284474; PMCID: PMC4227578.
        View in: PubMed, PubMed Central
      11. Molinski T. All natural: the renaissance of natural products chemistry. Org Lett. 2014 Aug 01; 16(15):3849-55. PMID: 25081565.
        View in: PubMed
      12. Molinski T. All natural: the renaissance of natural products chemistry. J Org Chem. 2014 Aug 01; 79(15):6765. PMID: 25081028.
        View in: PubMed
      13. Stout EP, Choi MY, Castro JE, Molinski T. Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: design, synthesis, and pharmacokinetic studies. J Med Chem. 2014 Jun 26; 57(12):5085-93. PMID: 24673739; PMCID: PMC4079331.
        View in: PubMed, PubMed Central
      14. Wang X, Morinaka BI, Molinski T. Structures and solution conformational dynamics of stylissamides G and H from the Bahamian sponge Stylissa caribica. J Nat Prod. 2014 Mar 28; 77(3):625-30. PMID: 24576291; PMCID: PMC3993948.
        View in: PubMed, PubMed Central
      15. Januar LA, Molinski T. Acremolin from Acremonium strictum is N(2),3-etheno-2'-isopropyl-1-methylguanine, not a 1H-azirine. Synthesis and structural revision. Org Lett. 2013 May 17; 15(10):2370-3. PMID: 23635003; PMCID: PMC3957326.
        View in: PubMed, PubMed Central
      16. Widom JR, Lee W, Perdomo-Ortiz A, Rappoport D, Molinski T, Aspuru-Guzik A, Marcus AH. Temperature-dependent conformations of a membrane supported zinc porphyrin tweezer by 2D fluorescence spectroscopy. J Phys Chem A. 2013 Jul 25; 117(29):6171-84. PMID: 23480874; PMCID: PMC3723700.
        View in: PubMed, PubMed Central
      17. Ko J, Molinski T. D-Glucosamine-derived synthons for assembly of L-threo-sphingoid bases. Total synthesis of rhizochalinin C. J Org Chem. 2013 Jan 18; 78(2):498-505. PMID: 23227909; PMCID: PMC3548972.
        View in: PubMed, PubMed Central
      18. Molinski T, Biegelmeyer R, Stout EP, Wang X, Frota ML, Henriques AT. Halisphingosines A and B, modified sphingoid bases from Haliclona tubifera. Assignment of configuration by circular dichroism and van't Hoff's principle of optical superposition. J Nat Prod. 2013 Mar 22; 76(3):374-81. PMID: 23268569; PMCID: PMC3969749.
        View in: PubMed, PubMed Central
      19. Molinski T, Morinaka BI. INTEGRATED APPROACHES TO THE CONFIGURATIONAL ASSIGNMENT OF MARINE NATURAL PRODUCTS. Tetrahedron. 2012 Nov 18; 68(46):9307-9343. PMID: 23814320.
        View in: PubMed
      20. Stout EP, Yu LC, Molinski T. Antifungal Diterpene Alkaloids from the Caribbean Sponge Agelas citrina: Unified Configurational Assignments of Agelasidines and Agelasines. European J Org Chem. 2012 Sep; 2012(27):5131-5135. PMID: 24653665.
        View in: PubMed
      21. Altamirano F, López JR, Henríquez C, Molinski T, Allen PD, Jaimovich E. Increased resting intracellular calcium modulates NF-?B-dependent inducible nitric-oxide synthase gene expression in dystrophic mdx skeletal myotubes. J Biol Chem. 2012 Jun 15; 287(25):20876-87. PMID: 22549782; PMCID: PMC3375511.
        View in: PubMed, PubMed Central
      22. Eltit JM, Bannister RA, Moua O, Altamirano F, Hopkins PM, Pessah IN, Molinski T, López JR, Beam KG, Allen PD. Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7923-8. PMID: 22547813; PMCID: PMC3356662.
        View in: PubMed, PubMed Central
      23. Stout EP, Wang YG, Romo D, Molinski T. Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica. Angew Chem Int Ed Engl. 2012 May 14; 51(20):4877-81. PMID: 22473581; PMCID: PMC3917718.
        View in: PubMed, PubMed Central
      24. Stout EP, Morinaka BI, Wang YG, Romo D, Molinski T. De novo synthesis of benzosceptrin C and nagelamide H from 7-15N-oroidin: implications for pyrrole-aminoimidazole alkaloid biosynthesis. J Nat Prod. 2012 Apr 27; 75(4):527-30. PMID: 22455452; PMCID: PMC3694594.
        View in: PubMed, PubMed Central
      25. Molinski T, Reynolds KA, Morinaka BI. Symplocin A, a linear peptide from the Bahamian cyanobacterium Symploca sp. Configurational analysis of N,N-dimethylamino acids by chiral-phase HPLC of naphthacyl esters. J Nat Prod. 2012 Mar 23; 75(3):425-31. PMID: 22360587; PMCID: PMC3694611.
        View in: PubMed, PubMed Central
      26. Morinaka BI, Molinski T. Mollenyne A, a long-chain chlorodibromohydrin amide from the sponge Spirastrella mollis. Org Lett. 2011 Dec 16; 13(24):6338-41. PMID: 22087509; PMCID: PMC3544366.
        View in: PubMed, PubMed Central
      27. Flores B, Molinski T. Assembly of the isoindolinone core of muironolide A by asymmetric intramolecular Diels-Alder cycloaddition. Org Lett. 2011 Aug 05; 13(15):3932-5. PMID: 21751773; PMCID: PMC4000739.
        View in: PubMed, PubMed Central
      28. Liu C, Molinski T. Preparation of a-amino acids by oxidative oxazoline-oxazinone rearrangement-hydrogenation (OOOH). Scope and limitations. Chem Asian J. 2011 Aug 01; 6(8):2022-7. PMID: 21751407.
        View in: PubMed
      29. Smith AB, Hogan AM, Liu Z, Razler TM, Meis RM, Morinaka BI, Molinski T. Phorboxazole Synthetic Studies: Design, Synthesis and Biological Evaluation of Phorboxazole A and Hemi-Phorboxazole A Related Analogues. Tetrahedron. 2011 Jul 08; 67(27-28):5069-5078. PMID: 21811346.
        View in: PubMed
      30. Dalisay DS, Saludes JP, Molinski T. Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans. Bioorg Med Chem. 2011 Nov 15; 19(22):6654-7. PMID: 21715177; PMCID: PMC3523195.
        View in: PubMed, PubMed Central
      31. Eltit JM, Li H, Ward CW, Molinski T, Pessah IN, Allen PD, Lopez JR. Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):7046-51. PMID: 21482776; PMCID: PMC3084091.
        View in: PubMed, PubMed Central
      32. Morinaka BI, Molinski T. Xestoproxamines A-C from Neopetrosia proxima. Assignment of absolute stereostructure of bis-piperidine alkaloids by integrated degradation-CD analysis. J Nat Prod. 2011 Mar 25; 74(3):430-40. PMID: 21341726; PMCID: PMC3957325.
        View in: PubMed, PubMed Central
      33. Molinski T, Ko J, Reynolds KA, Lievens SC, Skarda KR. N,N'-methyleno-didemnin A from the ascidian Trididemnum solidum. Complete NMR assignments and confirmation of the imidazolidinone ring by strategic analysis of 1J(CH). J Nat Prod. 2011 Apr 25; 74(4):882-7. PMID: 21341712; PMCID: PMC3694603.
        View in: PubMed, PubMed Central
      34. Ko J, Morinaka BI, Molinski T. Faulknerynes A-C from a Bahamian sponge Diplastrella sp.: stereoassignment by critical application of two exciton coupled CD methods. J Org Chem. 2011 Feb 04; 76(3):894-901. PMID: 21218782; PMCID: PMC3523196.
        View in: PubMed, PubMed Central
      35. Eltit JM, Feng W, Lopez JR, Padilla IT, Pessah IN, Molinski T, Fruen BR, Allen PD, Perez CF. Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+. J Biol Chem. 2010 Dec 03; 285(49):38453-62. PMID: 20926377; PMCID: PMC2992278.
        View in: PubMed, PubMed Central
      36. Molinski T. Microscale methodology for structure elucidation of natural products. Curr Opin Biotechnol. 2010 Dec; 21(6):819-26. PMID: 20880694; PMCID: PMC2982861.
        View in: PubMed, PubMed Central
      37. Skepper CK, Quach T, Molinski T. Total synthesis of enigmazole A from Cinachyrella enigmatica. Bidirectional bond constructions with an ambident 2,4-disubstituted oxazole synthon. J Am Chem Soc. 2010 Aug 04; 132(30):10286-92. PMID: 20590095.
        View in: PubMed
      38. Dalisay DS, Molinski T. Structure elucidation at the nanomole scale. 3. Phorbasides G-I from Phorbas sp. J Nat Prod. 2010 Apr 23; 73(4):679-82. PMID: 20184337; PMCID: PMC2859111.
        View in: PubMed, PubMed Central
      39. Morinaka BI, Pawlik JR, Molinski T. Amaranzoles B-F, imidazole-2-carboxy steroids from the marine sponge Phorbas amaranthus. C24-N- and C24-O-analogues from a divergent oxidative biosynthesis. J Org Chem. 2010 Apr 16; 75(8):2453-60. PMID: 20235564; PMCID: PMC2852487.
        View in: PubMed, PubMed Central
      40. Dalisay DS, Quach T, Molinski T. Liposomal circular dichroism. Assignment of remote stereocenters in plakinic acids K and L from a Plakortis-Xestospongia sponge association. Org Lett. 2010 Apr 02; 12(7):1524-7. PMID: 20205426; PMCID: PMC2846192.
        View in: PubMed, PubMed Central
      41. Wang YG, Morinaka BI, Reyes JC, Wolff JJ, Romo D, Molinski T. Synthesis of 7-(15)N-Oroidin and evaluation of utility for biosynthetic studies of pyrrole-imidazole alkaloids by microscale (1)H-(15)N HSQC and FTMS. J Nat Prod. 2010 Mar 26; 73(3):428-34. PMID: 20095632; PMCID: PMC3544367.
        View in: PubMed, PubMed Central
      42. Pigza JA, Molinski T. Diastereoselective allylstannane additions to (S)-5,6-dihydro-2H-5-phenyloxazin-2-one. A concise synthesis of (S)-beta-methylisoleucine. Org Lett. 2010 Mar 19; 12(6):1256-9. PMID: 20163126; PMCID: PMC2837769.
        View in: PubMed, PubMed Central
      43. Eltit JM, Yang T, Li H, Molinski T, Pessah IN, Allen PD, Lopez JR. RyR1-mediated Ca2+ leak and Ca2+ entry determine resting intracellular Ca2+ in skeletal myotubes. J Biol Chem. 2010 Apr 30; 285(18):13781-7. PMID: 20207743; PMCID: PMC2859541.
        View in: PubMed, PubMed Central
      44. Rogers EW, Dalisay DS, Molinski T. Zwittermicin A: synthesis of analogs and structure-activity studies. Bioorg Med Chem Lett. 2010 Apr 01; 20(7):2183-5. PMID: 20189808; PMCID: PMC2845154.
        View in: PubMed, PubMed Central
      45. Molinski T. NMR of natural products at the 'nanomole-scale'. Nat Prod Rep. 2010 Mar; 27(3):321-9. PMID: 20179874.
        View in: PubMed
      46. Skepper CK, Dalisay DS, Molinski T. Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine. Bioorg Med Chem Lett. 2010 Mar 15; 20(6):2029-32. PMID: 20171099; PMCID: PMC2834865.
        View in: PubMed, PubMed Central
      47. Makarieva TN, Zakharenko AM, Dmitrenok PS, Guzii AG, Denisenko VA, Savina AS, Dalisay DS, Molinski T, Stonik VA. Isorhizochalin: a minor unprecedented bipolar sphingolipid of stereodivergent biogenesis from the Rhizochalina incrustata. Lipids. 2009 Dec; 44(12):1155-62. PMID: 19882184.
        View in: PubMed
      48. Rogers EW, Molinski T. (+)-Zwittermicin A. Rapid assembly of C9-C15 and a formal total synthesis. J Org Chem. 2009 Oct 16; 74(20):7660-4. PMID: 19746943; PMCID: PMC2759841.
        View in: PubMed, PubMed Central
      49. Smith AB, Liu Z, Hogan AM, Dalisay DS, Molinski T. Hemi-phorboxazole a: structure confirmation, analogue design and biological evaluation. Org Lett. 2009 Aug 20; 11(16):3766-9. PMID: 19637861; PMCID: PMC2743491.
        View in: PubMed, PubMed Central
      50. Pigza JA, Quach T, Molinski T. Oxazoline-oxazinone oxidative rearrangement. divergent syntheses of (2S,3S)-4,4,4-trifluorovaline and (2S,4S)-5,5,5-Trifluoroleucine. J Org Chem. 2009 Aug 07; 74(15):5510-5. PMID: 19537688.
        View in: PubMed
      51. Dalisay DS, Morinaka BI, Skepper CK, Molinski T. A tetrachloro polyketide hexahydro-1H-isoindolone, muironolide A, from the marine sponge Phorbas sp. natural products at the nanomole scale. J Am Chem Soc. 2009 Jun 10; 131(22):7552-3. PMID: 19453148.
        View in: PubMed
      52. Molinski T. Marine natural products. Clin Adv Hematol Oncol. 2009 Jun; 7(6):383-5. PMID: 19606073.
        View in: PubMed
      53. Dalisay DS, Molinski T. Structure elucidation at the nanomole scale. 2. Hemi-phorboxazole A from Phorbas sp. Org Lett. 2009 May 07; 11(9):1967-70. PMID: 19341267.
        View in: PubMed
      54. Mulder RJ, Shafer CM, Dalisay DS, Molinski T. Synthesis and structure-activity relationships of bengazole A analogs. Bioorg Med Chem Lett. 2009 Jun 01; 19(11):2928-30. PMID: 19419860; PMCID: PMC2691865.
        View in: PubMed, PubMed Central
      55. Dalisay DS, Molinski T. NMR quantitation of natural products at the nanomole scale. J Nat Prod. 2009 Apr; 72(4):739-44. PMID: 19399996; PMCID: PMC2753506.
        View in: PubMed, PubMed Central
      56. Dalisay DS, Rogers EW, Edison AS, Molinski T. Structure elucidation at the nanomole scale. 1. Trisoxazole macrolides and thiazole-containing cyclic peptides from the nudibranch Hexabranchus sanguineus. J Nat Prod. 2009 Apr; 72(4):732-8. PMID: 19254038; PMCID: PMC2753413.
        View in: PubMed, PubMed Central
      57. Dalisay DS, Tsukamoto S, Molinski T. Absolute configuration of the alpha,omega-bifunctionalized sphingolipid leucettamol A from Leucetta microrhaphis by deconvoluted exciton coupled CD. J Nat Prod. 2009 Mar 27; 72(3):353-9. PMID: 19159253; PMCID: PMC2765480.
        View in: PubMed, PubMed Central
      58. Molinski T. Nanomole-scale natural products discovery. Curr Opin Drug Discov Devel. 2009 Mar; 12(2):197-206. PMID: 19333865.
        View in: PubMed
      59. Morinaka BI, Pawlik JR, Molinski T. Amaroxocanes A and B: sulfated dimeric sterols defend the Caribbean coral reef sponge Phorbas amaranthus from fish predators. J Nat Prod. 2009 Feb 27; 72(2):259-64. PMID: 19143510.
        View in: PubMed
      60. Dalisay DS, Quach T, Nicholas GN, Molinski T. Amplification of the Cotton effect of a single chromophore through liposomal ordering-stereochemical assignment of plakinic acids I and J. Angew Chem Int Ed Engl. 2009; 48(24):4367-71. PMID: 19437515; PMCID: PMC2872062.
        View in: PubMed, PubMed Central
      61. Molinski T, Dalisay DS, Lievens SL, Saludes JP. Drug development from marine natural products. Nat Rev Drug Discov. 2009 Jan; 8(1):69-85. PMID: 19096380.
        View in: PubMed
      62. Skepper CK, Dalisay DS, Molinski T. Synthesis and antifungal activity of (-)-(Z)-dysidazirine. Org Lett. 2008 Nov 20; 10(22):5269-71. PMID: 18937483; PMCID: PMC2635126.
        View in: PubMed, PubMed Central
      63. Morinaka BI, Molinski T. Exciton coupling circular dichroism of an allylic N-imidazolyl group in amaranzole A, a marine natural product from Phorbas amaranthus. Chirality. 2008 Sep; 20(9):1066-70. PMID: 18690668; PMCID: PMC2615005.
        View in: PubMed, PubMed Central
      64. MacMillan JB, Xiong-Zhou G, Skepper CK, Molinski T. Phorbasides A-E, cytotoxic chlorocyclopropane macrolide glycosides from the marine sponge Phorbas sp. CD determination of C-methyl sugar configurations. J Org Chem. 2008 May 16; 73(10):3699-706. PMID: 18412387.
        View in: PubMed
      65. Skepper CK, Molinski T. Long-chain 2H-azirines with heterogeneous terminal halogenation from the marine sponge Dysidea fragilis. J Org Chem. 2008 Apr 04; 73(7):2592-7. PMID: 18321120.
        View in: PubMed
      66. Dadsetan S, Zakharova L, Molinski T, Fomina AF. Store-operated Ca2+ influx causes Ca2+ release from the intracellular Ca2+ channels that is required for T cell activation. J Biol Chem. 2008 May 02; 283(18):12512-9. PMID: 18316371.
        View in: PubMed
      67. Rogers EW, Dalisay DS, Molinski T. (+)-Zwittermicin A: assignment of its complete configuration by total synthesis of the enantiomer and implication of D-serine in its biosynthesis. Angew Chem Int Ed Engl. 2008; 47(42):8086-9. PMID: 18798190; PMCID: PMC3957322.
        View in: PubMed, PubMed Central
      68. Makarieva TN, Dmitrenok PS, Zakharenko AM, Denisenko VA, Guzii AG, Li R, Skepper CK, Molinski T, Stonik VA. Rhizochalins C and D from the sponge Rhizochalina incrustata. A rare threo-sphingolipid and a facile method for determination of the carbonyl position in alpha,omega-bifunctionalized ketosphingolipids. J Nat Prod. 2007 Dec; 70(12):1991-8. PMID: 18052325.
        View in: PubMed
      69. Schuetz A, Junker J, Leonov A, Lange OF, Molinski T, Griesinger C. Stereochemistry of sagittamide A from residual dipolar coupling enhanced NMR. J Am Chem Soc. 2007 Dec 12; 129(49):15114-5. PMID: 17999506.
        View in: PubMed
      70. Morinaka BI, Masuno MN, Pawlik JR, Molinski T. Amaranzole A, a new N-imidazolyl steroid from Phorbas amaranthus. Org Lett. 2007 Dec 06; 9(25):5219-22. PMID: 17990891.
        View in: PubMed
      71. Rogers EW, Molinski T. Highly polar spiroisoxazolines from the sponge Aplysina fulva. J Nat Prod. 2007 Jul; 70(7):1191-4. PMID: 17579462; PMCID: PMC2533261.
        View in: PubMed, PubMed Central
      72. Morinaka BI, Skepper CK, Molinski T. Ene-yne tetrahydrofurans from the sponge Xestospongia muta. exploiting a weak CD effect for assignment of configuration. Org Lett. 2007 May 10; 9(10):1975-8. PMID: 17439137.
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      73. Skepper CK, Macmillan JB, Zhou GX, Masuno MN, Molinski T. Chlorocyclopropane macrolides from the marine sponge Phorbas sp. assignment of the configurations of phorbasides A and B by quantitative CD. J Am Chem Soc. 2007 Apr 11; 129(14):4150-1. PMID: 17373800.
        View in: PubMed
      74. Saludes JP, Lievens SC, Molinski T. Occurrence of the alpha-glucosidase inhibitor 1,4-Dideoxy-1,4-imino-D-arabinitol and related iminopentitols in marine sponges. J Nat Prod. 2007 Mar; 70(3):436-8. PMID: 17378534.
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      75. Rogers EW, Molinski T. Asymmetric synthesis of diastereomeric diaminoheptanetetraols. A proposal for the configuration of (+)-zwittermicin a. Org Lett. 2007 Feb 01; 9(3):437-40. PMID: 17249781; PMCID: PMC2729442.
        View in: PubMed, PubMed Central
      76. Yang T, Esteve E, Pessah IN, Molinski T, Allen PD, López JR. Elevated resting [Ca(2+)](i) in myotubes expressing malignant hyperthermia RyR1 cDNAs is partially restored by modulation of passive calcium leak from the SR. Am J Physiol Cell Physiol. 2007 May; 292(5):C1591-8. PMID: 17182726.
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      77. Lievens SC, Molinski T. Progressive-convergent elucidation of stereochemistry in complex polyols. The absolute configuration of (-)-sagittamide A. J Am Chem Soc. 2006 Sep 13; 128(36):11764-5. PMID: 16953609; PMCID: PMC3340292.
        View in: PubMed, PubMed Central
      78. Masuno MN, Pessah IN, Olmstead MM, Molinski T. Simplified cyclic analogues of bastadin-5. Structure-activity relationships for modulation of the RyR1/FKBP12 Ca2+ channel complex. J Med Chem. 2006 Jul 27; 49(15):4497-511. PMID: 16854055; PMCID: PMC3987770.
        View in: PubMed, PubMed Central
      79. Linington RG, Robertson M, Gauthier A, Finlay BB, MacMillan JB, Molinski T, van Soest R, Andersen RJ. Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia. J Nat Prod. 2006 Feb; 69(2):173-7. PMID: 16499312.
        View in: PubMed
      80. Zhou GX, Molinski T. Manoalide derivatives from a sponge, Luffariella sp. J Asian Nat Prod Res. 2006 Jan-Mar; 8(1-2):15-20. PMID: 16753777.
        View in: PubMed
      81. Ta TA, Feng W, Molinski T, Pessah IN. Hydroxylated xestospongins block inositol-1,4,5-trisphosphate-induced Ca2+ release and sensitize Ca2+-induced Ca2+ release mediated by ryanodine receptors. Mol Pharmacol. 2006 Feb; 69(2):532-8. PMID: 16249374.
        View in: PubMed
      82. Makarieva TN, Denisenko VA, Dmitrenok PS, Guzii AG, Santalova EA, Stonik VA, Macmillan JB, Molinski T. Oceanalin A, a hybrid alpha,omega-bifunctionalized sphingoid tetrahydroisoquinoline beta-glycoside from the marine sponge Oceanapia sp. Org Lett. 2005 Jul 07; 7(14):2897-900. PMID: 15987164.
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      83. Rogers EW, de Oliveira MF, Berlinck RG, König GM, Molinski T. Stereochemical heterogeneity in Verongid sponge metabolites. Absolute stereochemistry of (+)-fistularin-3 and (+)-11-epi-fistularin-3 by microscale LCMS-Marfey's analysis. J Nat Prod. 2005 Jun; 68(6):891-6. PMID: 15974614.
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      84. Lievens SC, Molinski T. Sagittamides A and B. Polyacetoxy long-chain acyl amino acids from a didemnid ascidian. Org Lett. 2005 May 26; 7(11):2281-4. PMID: 15901189.
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      85. Masuno MN, Young DM, Hoepker AC, Skepper CK, Molinski T. Addition of Cl2C: to (-)-O-menthyl acrylate under sonication-phase-transfer catalysis. Efficient synthesis of (+)- and (-)-(2-chlorocyclopropyl)methanol. J Org Chem. 2005 May 13; 70(10):4162-5. PMID: 15876110.
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      86. Macmillan JB, Molinski T. Majusculoic acid, a brominated cyclopropyl fatty acid from a marine cyanobacterial mat assemblage. J Nat Prod. 2005 Apr; 68(4):604-6. PMID: 15844960.
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      87. Rogers EW, Molinski T. A cytotoxic carotenoid from the marine sponge Prianos osiros. J Nat Prod. 2005 Mar; 68(3):450-2. PMID: 15787458.
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      88. Makarieva TN, Guzii AG, Denisenko VA, Dmitrenok PS, Santalova EA, Pokanevich EV, Molinski T, Stonik VA. Rhizochalin A, a novel two-headed sphingolipid from the sponge Rhizochalina incrustata. J Nat Prod. 2005 Feb; 68(2):255-7. PMID: 15730256.
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      89. Lievens SC, Hope H, Molinski T. New 3-oxo-chol-4-en-24-oic acids from the marine soft coral Eleutherobia sp. J Nat Prod. 2004 Dec; 67(12):2130-2. PMID: 15620271.
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      90. Grubb CD, Zipp BJ, Ludwig-Müller J, Masuno MN, Molinski T, Abel S. Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis. Plant J. 2004 Dec; 40(6):893-908. PMID: 15584955.
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      91. Liu C, Masuno MN, Macmillan JB, Molinski T. Enantioselective total synthesis of (+)-milnamide A and evidence of its autoxidation to (+)-milnamide D. Angew Chem Int Ed Engl. 2004 Nov 12; 43(44):5951-4. PMID: 15547903.
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      92. Macmillan JB, Linington RG, Andersen RJ, Molinski T. Stereochemical assignment in acyclic lipids across long distance by circular dichroism: absolute stereochemistry of the aglycone of caminoside A. Angew Chem Int Ed Engl. 2004 Nov 12; 43(44):5946-51. PMID: 15547902.
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      93. Kossuga MH, MacMillan JB, Rogers EW, Molinski T, Nascimento GG, Rocha RM, Berlinck RG. (2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga. J Nat Prod. 2004 Nov; 67(11):1879-81. PMID: 15568780.
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      94. MacMillan JB, Molinski T. Long-range stereo-relay: relative and absolute configuration of 1,n-glycols from circular dichroism of liposomal porphyrin esters. J Am Chem Soc. 2004 Aug 18; 126(32):9944-5. PMID: 15303868.
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      95. Andersen RJ, Ireland CM, Molinski T, Bewley CA. Research achievement award--D. John Faulkner. J Nat Prod. 2004 Aug; 67(8):1239-51. PMID: 15332836.
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      96. Masuno MN, Pawlik JR, Molinski T. Phorbasterones A-D, cytotoxic nor-ring A steroids from the sponge Phorbas amaranthus. J Nat Prod. 2004 Apr; 67(4):731-3. PMID: 15104518.
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      97. Richter RK, Mickus DE, Rychnovsky SD, Molinski T. Differential modulation of the antifungal activity of amphotericin B by natural and ent-cholesterol. Bioorg Med Chem Lett. 2004 Jan 05; 14(1):115-8. PMID: 14684310.
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      98. Masuno MN, Molinski T. Cationic reduction of bastadin-4 to bastadin-5. Preparation of 5-[2h]-bastadin-5 by site-specific isotopic labeling. J Nat Prod. 2003 Jan; 66(1):112-4. PMID: 12542356.
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      99. MacMillan JB, Ernst-Russell MA, de Ropp JS, Molinski T. Lobocyclamides A-C, lipopeptides from a cryptic cyanobacterial mat containing Lyngbya confervoides. J Org Chem. 2002 Nov 15; 67(23):8210-5. PMID: 12423153.
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      100. Nicholas GM, Li R, MacMillan JB, Molinski T. Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols. Bioorg Med Chem Lett. 2002 Aug 19; 12(16):2159-62. PMID: 12127527.
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      101. MacMillan JB, Molinski T. Lobocyclamide B from Lyngbya confervoides. Configuration and asymmetric synthesis of beta-hydroxy-alpha-amino acids by (-)-sparteine-mediated aldol addition. Org Lett. 2002 May 30; 4(11):1883-6. PMID: 12027638.
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      102. MacMillan JB, Molinski T. Caylobolide A, a unique 36-membered macrolactone from a Bahamian Lyngbya majuscula. Org Lett. 2002 May 02; 4(9):1535-8. PMID: 11975622.
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      103. Moon SS, MacMillan JB, Olmstead MM, Ta TA, Pessah IN, Molinski T. (+)-7S-Hydroxyxestospongin A from the marine sponge Xestospongia sp. and absolute configuration of (+)-xestospongin D. J Nat Prod. 2002 Mar; 65(3):249-54. PMID: 11908959.
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      104. Franz AH, Molinski T, Lebrilla CB. MALDI-FTMS characterization of oligosaccharides labeled with 9-aminofluorene. J Am Soc Mass Spectrom. 2001 Dec; 12(12):1254-61. PMID: 11766752.
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      105. Haak LL, Song LS, Molinski T, Pessah IN, Cheng H, Russell JT. Sparks and puffs in oligodendrocyte progenitors: cross talk between ryanodine receptors and inositol trisphosphate receptors. J Neurosci. 2001 Jun 01; 21(11):3860-70. PMID: 11356874.
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      106. MacMillan JB, Trousdale EK, Molinski T. Structure of (-)-neodysidenin from Dysidea herbacea. Implications for biosynthesis of 5,5,5-trichloroleucine peptides. Org Lett. 2000 Aug 24; 2(17):2721-3. PMID: 10990437.
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      107. MacMillan JB, Molinski T. Herbacic acid, a simple prototype of 5,5,5-trichloroleucine metabolites from the sponge Dysidea herbacea. J Nat Prod. 2000 Jan; 63(1):155-7. PMID: 10650102.
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      108. Nicholas GM, Hong TW, Molinski T, Lerch ML, Cancilla MT, Lebrilla CB. Oceanapiside, an antifungal bis-alpha,omega-amino alcohol glycoside from the marine sponge Oceanapia phillipensis. J Nat Prod. 1999 Dec; 62(12):1678-81. PMID: 10654417.
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      109. Chen L, Molinski T, Pessah IN. Bastadin 10 stabilizes the open conformation of the ryanodine-sensitive Ca(2+) channel in an FKBP12-dependent manner. J Biol Chem. 1999 Nov 12; 274(46):32603-12. PMID: 10551814.
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      110. Mulder RJ, Shafer CM, Molinski T. First Total Synthesis of Bengazole A. J Org Chem. 1999 Jun 25; 64(13):4995-4998. PMID: 11674590.
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      111. Shafer CM, Molinski T. Practical synthesis of 2,6-dideoxy-D-lyxo-hexose ("2-deoxy-D-fucose") from D-galactose. Carbohydr Res. 1998 Aug; 310(4):223-8. PMID: 9821260.
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      112. Shafer CM, Molinski T. Monosubstituted Oxazoles. 1. Synthesis of 5-Substituted Oxazoles by Directed Alkylation. J Org Chem. 1998 Feb 06; 63(3):551-555. PMID: 11672044.
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      113. Hong TW, Jímenez DR, Molinski T. Agelastatins C and D, new pentacyclic bromopyrroles from the sponge Cymbastela sp., and potent arthropod toxicity of (-)-agelastatin A. J Nat Prod. 1998 Jan; 61(1):158-61. PMID: 9461668.
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      114. Gafni J, Munsch JA, Lam TH, Catlin MC, Costa LG, Molinski T, Pessah IN. Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron. 1997 Sep; 19(3):723-33. PMID: 9331361.
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      115. Pessah IN, Molinski T, Meloy TD, Wong P, Buck ED, Allen PD, Mohr FC, Mack MM. Bastadins relate ryanodine-sensitive and -insensitive Ca2+ efflux pathways in skeletal SR and BC3H1 cells. Am J Physiol. 1997 Feb; 272(2 Pt 1):C601-14. PMID: 9124304.
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      116. Franklin MA, Penn SG, Lebrilla CB, Lam TH, Pessah IN, Molinski T. Bastadin 20 and bastadin O-sulfate esters from Ianthella basta: novel modulators of the Ry1R FKBP12 receptor complex. J Nat Prod. 1996 Dec; 59(12):1121-7. PMID: 8988595.
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      117. Preston CM, Wu KY, Molinski T, DeLong EF. A psychrophilic crenarchaeon inhabits a marine sponge: Cenarchaeum symbiosum gen. nov., sp. nov. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6241-6. PMID: 8692799; PMCID: PMC39006.
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      118. Searle PA, Richter RK, Molinski T. Bengazoles C-G from the Sponge Jaspis sp. Synthesis of the Side Chain and Determination of Absolute Configuration. J Org Chem. 1996 Jun 14; 61(12):4073-4079. PMID: 11667285.
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      119. Wu J, Fannin ST, Franklin MA, Molinski T, Lebrilla CB. Exact mass determination for elemental analysis of ions produced by matrix-assisted laser desorption. Anal Chem. 1995 Oct 15; 67(20):3788-92. PMID: 8644924.
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      120. Searle PA, Molinski T. 4-Dehydroecdysterone, a new ecdysteroid from the zoanthid Parazoanthus sp. J Nat Prod. 1995 Feb; 58(2):264-8. PMID: 7769393.
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      121. Mack MM, Molinski T, Buck ED, Pessah IN. Novel modulators of skeletal muscle FKBP12/calcium channel complex from Ianthella basta. Role of FKBP12 in channel gating. J Biol Chem. 1994 Sep 16; 269(37):23236-49. PMID: 8083229.
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      122. Antonio J, Molinski T. Screening of marine invertebrates for the presence of ergosterol-sensitive antifungal compounds. J Nat Prod. 1993 Jan; 56(1):54-61. PMID: 8450321.
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      123. Molinski T. Developments in marine natural products. Receptor-specific bioactive compounds. J Nat Prod. 1993 Jan; 56(1):1-8. PMID: 8450313.
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      124. Taylor SW, Molinski T, Rzepecki LM, Waite JH. Oxidation of peptidyl 3,4-dihydroxyphenylalanine analogues: implications for the biosynthesis of tunichromes and related oligopeptides. J Nat Prod. 1991 May-Jun; 54(3):918-22. PMID: 1955891.
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      125. Macleod JK, Moeller PD, Molinski T, Koul O. Antifeedant activity againstSpodoptera litera larvae and [(13)C]NMR spectral assignments of the meliatoxins. J Chem Ecol. 1990 Aug; 16(8):2511-8. PMID: 24264216.
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