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    Sylvia Evans

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentSchool of Pharmacy and Pharmaceutical Science
    Address9500 Gilman Drive #0613C
    CA La Jolla 92093
    Phone858-822-2452
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      Collapse Biography 
      Collapse Education and Training
      Ph.D.University of British Colombia

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Developmental Regulatory Genomics of Human Cardiovascular Lineages
      NIH/NHLBI UM1HL128773Aug 1, 2015 - Jul 31, 2020
      Role: Principal Investigator
      Luma in Cardiac Function and Disease
      NIH/NHLBI R01HL123626Aug 1, 2014 - Jul 31, 2018
      Role: Co-Principal Investigator
      The Role of Dot1L in developing and postnatal heart
      NIH/NHLBI R01HL123747Aug 1, 2014 - Jul 31, 2018
      Role: Principal Investigator
      Endocardial Pathways Regulated by Tbx20
      NIH/NHLBI R01HL119967Dec 15, 2013 - Nov 30, 2017
      Role: Principal Investigator
      REGULATORY GENOMIC STUDIES IN A COHORT OF IPS CELL DERIVED CARDIOMYOCYTES
      NIH/NHLBI U01HL107442Jul 15, 2011 - Jun 30, 2017
      Role: Principal Investigator
      Approaches to Cardiac Regeneration
      NIH/NHLBI DP1HL117649Sep 30, 2009 - Jul 31, 2014
      Role: Principal Investigator
      Approaches to Cardiac Regeneration
      NIH DP1OD006428Sep 30, 2009 - Jul 31, 2014
      Role: Principal Investigator
      Mechanisms of Islet1 Action in Heart Development
      NIH/NHLBI R01HL074066Jul 1, 2003 - Mar 31, 2012
      Role: Principal Investigator
      The Role of Tbox20 in Cardiac Development &Adult Heart
      NIH/NHLBI R01HL070867Jul 1, 2002 - Apr 30, 2011
      Role: Principal Investigator
      Temporal and Spatial BMP Signalling and Cardiogenesis
      NIH/NHLBI R01HL066276Sep 1, 2001 - Aug 31, 2005
      Role: Principal Investigator
      TINMAN HOMOLOGUES AND CARDIAC DEVELOPMENT
      NIH/NHLBI R01HL056892Jan 15, 1998 - Dec 31, 2001
      Role: Principal Investigator
      MOLECULAR PHYSIOLOGY OF HEART FAILURE
      NIH/NHLBI P50HL053773Feb 1, 1995 - Feb 28, 2006
      Role: Co-Investigator
      GENE EXPRESSION IN NORMAL/ABNORMAL CARDIAC DEVELOPMENT
      NIH/NHLBI R29HL046761Apr 1, 1992 - Mar 31, 1997
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak RB, Pappas CT, Gregorio CC, Evans S, Fowler VM, Chen J. HSPB7 is indispensable for heart development by modulating actin filament assembly. Proc Natl Acad Sci U S A. 2017 Oct 23. PMID: 29078393.
        View in: PubMed
      2. van Vliet PP, Lin L, Boogerd CJ, Martin JF, Andelfinger G, Grossfeld PD, Evans S. Tissue specific requirements for WNT11 in developing outflow tract and dorsal mesenchymal protrusion. Dev Biol. 2017 Sep 01; 429(1):249-259. PMID: 28669819.
        View in: PubMed
      3. Guimarães-Camboa N, Evans S. Are Perivascular Adipocyte Progenitors Mural Cells or Adventitial Fibroblasts? Cell Stem Cell. 2017 May 04; 20(5):587-589. PMID: 28475883.
        View in: PubMed
      4. Guimarães-Camboa N, Cattaneo P, Sun Y, Moore-Morris T, Gu Y, Dalton ND, Rockenstein E, Masliah E, Peterson KL, Stallcup WB, Chen J, Evans S. Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017 Jan 09. PMID: 28111199.
        View in: PubMed
      5. Guimarães-Camboa N, Evans S. Redox Paradox: Can Hypoxia Heal Ischemic Hearts? Dev Cell. 2016 11 21; 39(4):392-394. PMID: 27875683.
        View in: PubMed
      6. Mezzano V, Liang Y, Wright AT, Lyon RC, Pfeiffer E, Song MY, Gu Y, Dalton ND, Scheinman M, Peterson KL, Evans S, Fowler S, Cerrone M, McCulloch AD, Sheikh F. Desmosomal junctions are necessary for adult sinus node function. Cardiovasc Res. 2016 Aug 01; 111(3):274-86. PMID: 27097650; PMCID: PMC4957488 [Available on 08/01/17].
        View in: PubMed, PubMed Central
      7. Hirai M, Chen J, Evans S. Generation and Characterization of a Tissue-Specific Centrosome Indicator Mouse Line. Genesis. 2016 05; 54(5):286-96. PMID: 26990996; PMCID: PMC5021172.
        View in: PubMed, PubMed Central
      8. Hirai M, Cattaneo P, Chen J, Evans S. Revisiting Preadolescent Cardiomyocyte Proliferation in Mice. Circ Res. 2016 Mar 18; 118(6):916-9. PMID: 26987912.
        View in: PubMed
      9. Boogerd CJ, Evans S. TBX5 and NuRD Divide the Heart. Dev Cell. 2016 Feb 08; 36(3):242-4. PMID: 26859347.
        View in: PubMed
      10. Vitre B, Holland AJ, Kulukian A, Shoshani O, Hirai M, Wang Y, Maldonado M, Cho T, Boubaker J, Swing DA, Tessarollo L, Evans S, Fuchs E, Cleveland DW. Chronic centrosome amplification without tumorigenesis. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):E6321-30. PMID: 26578792; PMCID: PMC4655534.
        View in: PubMed, PubMed Central
      11. Hirai M, Chen J, Evans S. Tissue-Specific Cell Cycle Indicator Reveals Unexpected Findings for Cardiac Myocyte Proliferation. Circ Res. 2016 Jan 08; 118(1):20-8. PMID: 26472817.
        View in: PubMed
      12. Guimarães-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson RS, Chen J, McCulloch AD, Nobrega MA, Evans S, Zambon AC. HIF1a Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes. Dev Cell. 2015 Jun 08; 33(5):507-21. PMID: 26028220; PMCID: PMC4509618.
        View in: PubMed, PubMed Central
      13. Mu Y, Jing R, Peter AK, Lange S, Lin L, Zhang J, Ouyang K, Fang X, Veevers J, Zhou X, Evans S, Cheng H, Chen J. Cypher and Enigma homolog protein are essential for cardiac development and embryonic survival. J Am Heart Assoc. 2015 May 05; 4(5). PMID: 25944877; PMCID: PMC4599425.
        View in: PubMed, PubMed Central
      14. Ouyang K, Leandro Gomez-Amaro R, Stachura DL, Tang H, Peng X, Fang X, Traver D, Evans S, Chen J. Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia. Nat Commun. 2014 Sep 12; 5:4814. PMID: 25215520.
        View in: PubMed
      15. Moore-Morris T, Tallquist MD, Evans S. Sorting out where fibroblasts come from. Circ Res. 2014 Sep 12; 115(7):602-4. PMID: 25214570; PMCID: PMC4176694.
        View in: PubMed, PubMed Central
      16. Liang X, Evans S, Sun Y. Insights into cardiac conduction system formation provided by HCN4 expression. Trends Cardiovasc Med. 2015 Jan; 25(1):1-9. PMID: 25442735.
        View in: PubMed
      17. Chen J, Fu R, Cui Y, Pan J, Li Y, Zhang X, Evans S, Cui S, Liu J. LIM-homeodomain transcription factor Isl-1 mediates kisspeptin's effect on insulin secretion in mice. Mol Endocrinol. 2014 Aug; 28(8):1276-90. PMID: 24956377.
        View in: PubMed
      18. Banerjee I, Zhang J, Moore-Morris T, Pfeiffer E, Buchholz KS, Liu A, Ouyang K, Stroud MJ, Gerace L, Evans S, McCulloch A, Chen J. Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response. PLoS Genet. 2014 Feb; 10(2):e1004114. PMID: 24586179; PMCID: PMC3930490.
        View in: PubMed, PubMed Central
      19. Lyon RC, Mezzano V, Wright AT, Pfeiffer E, Chuang J, Banares K, Castaneda A, Ouyang K, Cui L, Contu R, Gu Y, Evans S, Omens JH, Peterson KL, McCulloch AD, Sheikh F. Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. Hum Mol Genet. 2014 Mar 01; 23(5):1134-50. PMID: 24108106; PMCID: PMC3919010.
        View in: PubMed, PubMed Central
      20. Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Zhang Z, Zhong TP, Yang X, Yang Z, Yan Y, Baldini A, Sun Y, Lu J, Schwartz RJ, Evans S, Gittenberger-de Groot AC, Red-Horse K, Zhou B. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res. 2013 Sep; 23(9):1075-90. PMID: 23797856; PMCID: PMC3760626.
        View in: PubMed, PubMed Central
      21. Liang X, Wang G, Lin L, Lowe J, Zhang Q, Bu L, Chen Y, Chen J, Sun Y, Evans S. HCN4 dynamically marks the first heart field and conduction system precursors. Circ Res. 2013 Aug 02; 113(4):399-407. PMID: 23743334; PMCID: PMC4017870.
        View in: PubMed, PubMed Central
      22. Boogerd CJ, Evans S. To activate or not to activate: the existential dilemma of an enhancer. Circ Res. 2013 Mar 29; 112(7):985-7. PMID: 23538274.
        View in: PubMed
      23. Banerjee I, Moore Morris T, Evans S, Chen J. Thymosin ß4 is not required for embryonic viability or vascular development. Circ Res. 2013 Feb 01; 112(3):e25-8. PMID: 23371905; PMCID: PMC3712119.
        View in: PubMed, PubMed Central
      24. Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans S, Dillmann W, Glass CK, Brenner DA. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. PMID: 22566629; PMCID: PMC3386114.
        View in: PubMed, PubMed Central
      25. Weinberger F, Mehrkens D, Friedrich FW, Stubbendorff M, Hua X, Müller JC, Schrepfer S, Evans S, Carrier L, Eschenhagen T. Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart. Circ Res. 2012 May 11; 110(10):1303-10. PMID: 22427341.
        View in: PubMed
      26. Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans S, Chen J. Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012 Feb 03; 110(3):456-64. PMID: 22158707; PMCID: PMC3739283.
        View in: PubMed, PubMed Central
      27. Shen T, Aneas I, Sakabe N, Dirschinger RJ, Wang G, Smemo S, Westlund JM, Cheng H, Dalton N, Gu Y, Boogerd CJ, Cai CL, Peterson K, Chen J, Nobrega MA, Evans S. Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. J Clin Invest. 2011 Dec; 121(12):4640-54. PMID: 22080862; PMCID: PMC3223071.
        View in: PubMed, PubMed Central
      28. Milgrom-Hoffman M, Harrelson Z, Ferrara N, Zelzer E, Evans S, Tzahor E. The heart endocardium is derived from vascular endothelial progenitors. Development. 2011 Nov; 138(21):4777-87. PMID: 21989917; PMCID: PMC3190386.
        View in: PubMed, PubMed Central
      29. Hunt DL, Campbell PH, Zambon AC, Vranizan K, Evans S, Kuo HC, Yamaguchi KD, Omens JH, McCulloch AD. Early postmyocardial infarction survival in Murphy Roths Large mice is mediated by attenuated apoptosis and inflammation but depends on genetic background. Exp Physiol. 2012 Jan; 97(1):102-14. PMID: 21967898; PMCID: PMC3253239.
        View in: PubMed, PubMed Central
      30. Cheng H, Zheng M, Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui L, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans S, Knowlton KU, Sheikh F, Chen J. Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet. 2011 May 01; 20(9):1751-62. PMID: 21303826; PMCID: PMC3071671.
        View in: PubMed, PubMed Central
      31. Evans S, Moretti A, Laugwitz KL. MicroRNAs in a cardiac loop: progenitor or myocyte? Dev Cell. 2010 Dec 14; 19(6):787-8. PMID: 21145492; PMCID: PMC3035161.
        View in: PubMed, PubMed Central
      32. Evans S, Yelon D, Conlon FL, Kirby ML. Myocardial lineage development. Circ Res. 2010 Dec 10; 107(12):1428-44. PMID: 21148449; PMCID: PMC3073310.
        View in: PubMed, PubMed Central
      33. Cheng H, Kimura K, Peter AK, Cui L, Ouyang K, Shen T, Liu Y, Gu Y, Dalton ND, Evans S, Knowlton KU, Peterson KL, Chen J. Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res. 2010 Aug 06; 107(3):348-56. PMID: 20538684; PMCID: PMC3684396.
        View in: PubMed, PubMed Central
      34. Liang X, Sun Y, Ye M, Scimia MC, Cheng H, Martin J, Wang G, Rearden A, Wu C, Peterson KL, Powell HC, Evans S, Chen J. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation. 2009 Aug 18; 120(7):568-76. PMID: 19652092; PMCID: PMC2738591.
        View in: PubMed, PubMed Central
      35. Harel I, Nathan E, Tirosh-Finkel L, Zigdon H, Guimarães-Camboa N, Evans S, Tzahor E. Distinct origins and genetic programs of head muscle satellite cells. Dev Cell. 2009 Jun; 16(6):822-32. PMID: 19531353; PMCID: PMC3684422.
        View in: PubMed, PubMed Central
      36. Sun Y, Dykes IM, Liang X, Eng SR, Evans S, Turner EE. A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci. 2008 Nov; 11(11):1283-93. PMID: 18849985; PMCID: PMC2605652.
        View in: PubMed, PubMed Central
      37. Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans S, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU. Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest. 2008 Aug; 118(8):2758-70. PMID: 18636119; PMCID: PMC2467382.
        View in: PubMed, PubMed Central
      38. Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans S. A myocardial lineage derives from Tbx18 epicardial cells. Nature. 2008 Jul 03; 454(7200):104-8. PMID: 18480752.
        View in: PubMed
      39. Nathan E, Monovich A, Tirosh-Finkel L, Harrelson Z, Rousso T, Rinon A, Harel I, Evans S, Tzahor E. The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development. Development. 2008 Feb; 135(4):647-57. PMID: 18184728.
        View in: PubMed
      40. Zhou W, Lin L, Majumdar A, Li X, Zhang X, Liu W, Etheridge L, Shi Y, Martin J, Van de Ven W, Kaartinen V, Wynshaw-Boris A, McMahon AP, Rosenfeld MG, Evans S. Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet. 2007 Oct; 39(10):1225-34. PMID: 17767158.
        View in: PubMed
      41. Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, Moon RT, Gruber P, Evans S, Ding S, Chien KR. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 2007 Aug 16; 1(2):165-79. PMID: 18371348.
        View in: PubMed
      42. Lin L, Cui L, Zhou W, Dufort D, Zhang X, Cai CL, Bu L, Yang L, Martin J, Kemler R, Rosenfeld MG, Chen J, Evans S. Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9313-8. PMID: 17519333; PMCID: PMC1890491.
        View in: PubMed, PubMed Central
      43. Liang X, Sun Y, Schneider J, Ding JH, Cheng H, Ye M, Bhattacharya S, Rearden A, Evans S, Chen J. Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures. Circ Res. 2007 Mar 02; 100(4):527-35. PMID: 17272814.
        View in: PubMed
      44. Sun Y, Liang X, Najafi N, Cass M, Lin L, Cai CL, Chen J, Evans S. Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol. 2007 Apr 01; 304(1):286-96. PMID: 17258700; PMCID: PMC2582044.
        View in: PubMed, PubMed Central
      45. Evans S, Mummery C, Doevendans PA. Progenitor cells for cardiac repair. Semin Cell Dev Biol. 2007 Feb; 18(1):153-60. PMID: 17321172.
        View in: PubMed
      46. Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans S, Laugwitz KL, Chien KR. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 2006 Dec 15; 127(6):1151-65. PMID: 17123592.
        View in: PubMed
      47. Lin L, Bu L, Cai CL, Zhang X, Evans S. Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev Biol. 2006 Jul 15; 295(2):756-63. PMID: 16687132.
        View in: PubMed
      48. Yang L, Cai CL, Lin L, Qyang Y, Chung C, Monteiro RM, Mummery CL, Fishman GI, Cogen A, Evans S. Isl1Cre reveals a common Bmp pathway in heart and limb development. Development. 2006 Apr; 133(8):1575-85. PMID: 16556916.
        View in: PubMed
      49. Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development. 2005 May; 132(10):2475-87. PMID: 15843407.
        View in: PubMed
      50. Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 Feb 10; 433(7026):647-53. PMID: 15703750.
        View in: PubMed
      51. Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans S, Clark B, Feramisco JR, Giles W, Ho SY, Benson DW, Silberbach M, Shou W, Chien KR. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell. 2004 Apr 30; 117(3):373-86. PMID: 15109497.
        View in: PubMed
      52. Garcia-Frigola C, Shi Y, Evans S. Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development. Gene Expr Patterns. 2003 Dec; 3(6):777-83. PMID: 14643687.
        View in: PubMed
      53. Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, Evans S. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell. 2003 Dec; 5(6):877-89. PMID: 14667410.
        View in: PubMed
      54. Huang C, Sheikh F, Hollander M, Cai C, Becker D, Chu PH, Evans S, Chen J. Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis. Development. 2003 Dec; 130(24):6111-9. PMID: 14573518.
        View in: PubMed
      55. Kondo RP, Anderson RH, Kupershmidt S, Roden DM, Evans S. Development of the cardiac conduction system as delineated by minK-lacZ. J Cardiovasc Electrophysiol. 2003 Apr; 14(4):383-91. PMID: 12741710.
        View in: PubMed
      56. Huang C, Zhou Q, Liang P, Hollander MS, Sheikh F, Li X, Greaser M, Shelton GD, Evans S, Chen J. Characterization and in vivo functional analysis of splice variants of cypher. J Biol Chem. 2003 Feb 28; 278(9):7360-5. PMID: 12499364.
        View in: PubMed
      57. Fu Y, Ruiz-Lozano P, Evans S. A rat homeobox gene, rNKx-2.5, is a homologue of the tinman gene in Drosophila and is mainly expressed during heart development. Dev Genes Evol. 1997 Nov; 207(5):352-358. PMID: 27747432.
        View in: PubMed
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