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    Susan Taylor

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address9500 Gilman Drive #0654
    CA La Jolla 92093
    Phone858-534-3677
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      San Diego Center for Systems Biology: From Maps to Models
      NIH/NIGMS P50GM085764Jul 1, 2008 - May 31, 2019
      Role: Co-Investigator
      ASSEMBLY OF SIGNALING NETWORKS
      NIH/NIDDK R13DK057994Mar 20, 2000 - Feb 28, 2001
      Role: Principal Investigator
      PKA & PKC Targeting Mechanisms (Program Project)
      NIH/NIDDK P01DK054441Dec 15, 1998 - Mar 31, 2018
      Role: Principal Investigator
      NATIONAL BIOMEDICAL COMPUTATION RESOURCE
      NIH P41RR008605Apr 15, 1994 - Apr 30, 2014
      Role: Co-Investigator
      MOLECULAR BIOPHYSICS TRAINING PROGRAM
      NIH/NIGMS T32GM008326Jul 1, 1989 - Jun 30, 2021
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator
      GORDON RESEARCH CONFERENCE ON SECOND MESSENGERS
      NIH/NIGMS R13GM036850Jun 23, 1986 - May 31, 1987
      Role: Principal Investigator
      Assembly and regulation of dynamic PKA macromolecular signaling systems
      NIH/NIGMS R01GM034921Sep 25, 1985 - May 31, 2018
      Role: Principal Investigator
      Protein Kinase - Primary Structure and cAMP Interaction
      NIH/NIGMS R01GM019301May 1, 1978 - Nov 30, 2014
      Role: Principal Investigator
      PROTEIN KINASE: PRIMARY STRUCTURE AND CAMP INTERACTION
      NIH/NIGMS R37GM019301May 1, 1978 - Apr 30, 2005
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hao Y, Canavan C, Taylor S, Maillard RA. Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers. Sci Rep. 2017 Sep 07; 7(1):10843. PMID: 28883488.
        View in: PubMed
      2. Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH, Taylor S, Perkins GA. Sub-mitochondrial localization of genetic-tagged MIB interacting partners: Mic19, Mic60 and Sam50. J Cell Sci. 2017 Aug 14. PMID: 28808085.
        View in: PubMed
      3. P Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC, Kornev AP, Taylor S, Amaro RE. Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIa. Biochemistry. 2017 Mar 14; 56(10):1536-1545. PMID: 28221775.
        View in: PubMed
      4. Ahuja LG, Kornev AP, McClendon CL, Veglia G, Taylor S. Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proc Natl Acad Sci U S A. 2017 Feb 07; 114(6):E931-E940. PMID: 28115705.
        View in: PubMed
      5. Ilouz R, Lev-Ram V, Bushong EA, Stiles TL, Friedmann-Morvinski D, Douglas C, Goldberg G, Ellisman MH, Taylor S. Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain. Elife. 2017 Jan 12; 6. PMID: 28079521.
        View in: PubMed
      6. Bruystens JG, Wu J, Fortezzo A, Del Rio J, Nielsen C, Blumenthal DK, Rock R, Stefan E, Taylor S. Structure of a PKA RIa Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J Mol Biol. 2016 Dec 04; 428(24 Pt B):4890-4904. PMID: 27825928.
        View in: PubMed
      7. Taylor S, Minor K, Shmon CL, Shelton GD, Patterson EE, Mickelson JR. Border Collie Collapse: Owner Survey Results and Veterinary Description of Videotaped Episodes. J Am Anim Hosp Assoc. 2016 Nov/Dec; 52(6):364-370. PMID: 27685362.
        View in: PubMed
      8. Taylor S, Shmon C, Su L, Epp T, Minor K, Mickelson J, Patterson E, Shelton GD. Evaluation of Dogs with Border Collie Collapse, Including Response to Two Standardized Strenuous Exercise Protocols. J Am Anim Hosp Assoc. 2016 Sep-Oct; 52(5):281-90. PMID: 27487345.
        View in: PubMed
      9. Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor S, Stefan E. Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling. Proc Natl Acad Sci U S A. 2016 Jul 12; 113(28):7786-91. PMID: 27357676; PMCID: PMC4948347.
      10. Burgers PP, Bruystens J, Burnley RJ, Nikolaev VO, Keshwani M, Wu J, Janssen BJ, Taylor S, Heck AJ, Scholten A. Structure of smAKAP and its regulation by PKA-mediated phosphorylation. FEBS J. 2016 Jun; 283(11):2132-48. PMID: 27028580; PMCID: PMC4980077 [Available on 06/01/17].
      11. Kim J, Li G, Walters MA, Taylor S, Veglia G. Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A. Structure. 2016 Mar 01; 24(3):353-63. PMID: 26833386; PMCID: PMC4775281 [Available on 03/01/17].
      12. Chávez-Vargas L, Adame-García SR, Cervantes-Villagrana RD, Castillo-Kauil A, Bruystens JG, Fukuhara S, Taylor S, Mochizuki N, Reyes-Cruz G, Vázquez-Prado J. Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING. J Biol Chem. 2016 Mar 18; 291(12):6182-99. PMID: 26797121; PMCID: PMC4813559 [Available on 03/18/17].
      13. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor S, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. PMID: 26748707; PMCID: PMC4831919.
      14. Akimoto M, McNicholl ET, Ramkissoon A, Moleschi K, Taylor S, Melacini G. Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIa. PLoS Biol. 2015; 13(11):e1002305. PMID: 26618408; PMCID: PMC4664472.
      15. Kornev AP, Taylor S. Dynamics-Driven Allostery in Protein Kinases. Trends Biochem Sci. 2015 Nov; 40(11):628-47. PMID: 26481499; PMCID: PMC4630092 [Available on 11/01/16].
      16. Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA, Taylor S. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12681-6. PMID: 26417071; PMCID: PMC4611605.
      17. Antal CE, Callender JA, Kornev AP, Taylor S, Newton AC. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C ßII. Cell Rep. 2015 Aug 25; 12(8):1252-60. PMID: 26279568; PMCID: PMC4551583.
      18. Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor S. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015 Sep 01; 23(9):1563-72. PMID: 26278174; PMCID: PMC4558360.
      19. Knape MJ, Ahuja LG, Bertinetti D, Burghardt NC, Zimmermann B, Taylor S, Herberg FW. Divalent Metal Ions Mg²? and Ca²? Have Distinct Effects on Protein Kinase A Activity and Regulation. ACS Chem Biol. 2015 Oct 16; 10(10):2303-15. PMID: 26200257; PMCID: PMC4714867 [Available on 10/16/16].
      20. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor S, Insel PA. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. PMID: 26203188; PMCID: PMC4571978.
      21. Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor S. Single Turnover Autophosphorylation Cycle of the PKA RIIß Holoenzyme. PLoS Biol. 2015 Jul; 13(7):e1002192. PMID: 26158466; PMCID: PMC4497662.
      22. Malmstrom RD, Kornev AP, Taylor S, Amaro RE. Allostery through the computational microscope: cAMP activation of a canonical signalling domain. Nat Commun. 2015 Jul 06; 6:7588. PMID: 26145448; PMCID: PMC4504738.
      23. Li GC, Srivastava AK, Kim J, Taylor S, Veglia G. Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors. Biochemistry. 2015 Jul 07; 54(26):4042-9. PMID: 26030372; PMCID: PMC4498444.
      24. Zhang P, Kornev AP, Wu J, Taylor S. Discovery of Allostery in PKA Signaling. Biophys Rev. 2015 Jun 01; 7(2):227-238. PMID: 26097522.
        View in: PubMed
      25. Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor S, Molinolo AA, Gutkind JS. Inactivation of a Ga(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015 Jun; 17(6):793-803. PMID: 25961504; PMCID: PMC4449815.
      26. Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor S, Engler AJ, Yang J. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol. 2015 May; 17(5):678-88. PMID: 25893917; PMCID: PMC4452027.
      27. Taylor S, Shaw AS, Kannan N, Kornev AP. Integration of signaling in the kinome: Architecture and regulation of the aC Helix. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1567-74. PMID: 25891902; PMCID: PMC4577442 [Available on 10/01/16].
      28. Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor S, Langsley G, Kannan N. Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1575-85. PMID: 25847873; PMCID: PMC4577300 [Available on 10/01/16].
      29. Kim J, Masterson LR, Cembran A, Verardi R, Shi L, Gao J, Taylor S, Veglia G. Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3716-21. PMID: 25775607; PMCID: PMC4378435.
      30. McSkimming DI, Dastgheib S, Talevich E, Narayanan A, Katiyar S, Taylor S, Kochut K, Kannan N. ProKinO: a unified resource for mining the cancer kinome. Hum Mutat. 2015 Feb; 36(2):175-86. PMID: 25382819; PMCID: PMC4342772.
      31. Sarma GN, Moody IS, Ilouz R, Phan RH, Sankaran B, Hall RA, Taylor S. D-AKAP2:PKA RII:PDZK1 ternary complex structure: insights from the nucleation of a polyvalent scaffold. Protein Sci. 2015 Jan; 24(1):105-16. PMID: 25348485; PMCID: PMC4282416.
      32. Srivastava AK, McDonald LR, Cembran A, Kim J, Masterson LR, McClendon CL, Taylor S, Veglia G. Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling. Structure. 2014 Dec 02; 22(12):1735-43. PMID: 25458836; PMCID: PMC4255147.
      33. Niyitegeka JM, Bastidas AC, Newman RH, Taylor S, Ongeri EM. Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury. Am J Physiol Renal Physiol. 2015 Jan 01; 308(1):F56-68. PMID: 25354939; PMCID: PMC4281694.
      34. Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor S, Shaw AS. Kinase regulation by hydrophobic spine assembly in cancer. Mol Cell Biol. 2015 Jan; 35(1):264-76. PMID: 25348715; PMCID: PMC4295384.
      35. McClendon CL, Kornev AP, Gilson MK, Taylor S. Dynamic architecture of a protein kinase. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4623-31. PMID: 25319261; PMCID: PMC4217441.
      36. Boras BW, Kornev A, Taylor S, McCulloch AD. Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIa activation in response to cAMP binding. J Biol Chem. 2014 Oct 24; 289(43):30040-51. PMID: 25202018; PMCID: PMC4208011.
      37. Blumenthal DK, Copps J, Smith-Nguyen EV, Zhang P, Heller WT, Taylor S. The roles of the RIIß linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIß protein kinase A: a small angle x-ray and neutron scattering study. J Biol Chem. 2014 Oct 10; 289(41):28505-12. PMID: 25112875; PMCID: PMC4192500.
      38. Bastidas AC, Wu J, Taylor S. Molecular features of product release for the PKA catalytic cycle. Biochemistry. 2015 Jan 13; 54(1):2-10. PMID: 25077557; PMCID: PMC4295794.
      39. Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor S, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J. Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol. 2014 Mar 31; 204(7):1083-6. PMID: 24687277; PMCID: PMC3971754.
      40. Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor S. Kinases and pseudokinases: lessons from RAF. Mol Cell Biol. 2014 May; 34(9):1538-46. PMID: 24567368; PMCID: PMC3993607.
      41. Akimoto M, Moleschi K, Boulton S, VanSchouwen B, Selvaratnam R, Taylor S, Melacini G. Allosteric linkers in cAMP signalling. Biochem Soc Trans. 2014 Feb; 42(1):139-44. PMID: 24450641.
        View in: PubMed
      42. Bruystens JG, Wu J, Fortezzo A, Kornev AP, Blumenthal DK, Taylor S. PKA RIa homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. Structure. 2014 Jan 07; 22(1):59-69. PMID: 24316401; PMCID: PMC3963464.
      43. Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor S, Kornev AP. Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol. 2013 Oct; 11(10):e1001680. PMID: 24143133; PMCID: PMC3797032.
      44. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor S, Dillmann WH, Goldhaber JI, Ross RS. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. PMID: 24091324; PMCID: PMC3784521.
      45. Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM, Taylor S. Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Mol Cell Proteomics. 2013 Dec; 12(12):3744-58. PMID: 24030101; PMCID: PMC3861721.
      46. Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B, Taylor S. Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs. ACS Chem Biol. 2013 Oct 18; 8(10):2164-72. PMID: 23978166; PMCID: PMC3827627.
      47. Bastidas AC, Pierce LC, Walker RC, Johnson DA, Taylor S. Influence of N-myristylation and ligand binding on the flexibility of the catalytic subunit of protein kinase A. Biochemistry. 2013 Sep 17; 52(37):6368-79. PMID: 24003983; PMCID: PMC3788587.
      48. Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJ, Kornev AP, Taylor S, Shaw AS. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell. 2013 Aug 29; 154(5):1036-46. PMID: 23993095; PMCID: PMC3844432.
      49. Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor S, Melacini G. Signaling through dynamic linkers as revealed by PKA. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14231-6. PMID: 23946424; PMCID: PMC3761587.
      50. Taylor S, Shaw A, Hu J, Meharena HS, Kornev A. Pseudokinases from a structural perspective. Biochem Soc Trans. 2013 Aug; 41(4):981-6. PMID: 23863167; PMCID: PMC4399968.
      51. Laanemets K, Brandt B, Li J, Merilo E, Wang YF, Keshwani MM, Taylor S, Kollist H, Schroeder JI. Calcium-dependent and -independent stomatal signaling network and compensatory feedback control of stomatal opening via Ca2+ sensitivity priming. Plant Physiol. 2013 Oct; 163(2):504-13. PMID: 23766366; PMCID: PMC3793032.
      52. Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor S, Lai ZC, Guan KL. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev. 2013 Jun 01; 27(11):1223-32. PMID: 23752589; PMCID: PMC3690396.
      53. Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. The fractalkine/CX3CR1 system regulates ß cell function and insulin secretion. Cell. 2013 Apr 11; 153(2):413-25. PMID: 23582329; PMCID: PMC3717389.
      54. Taylor S, Zhang P, Steichen JM, Keshwani MM, Kornev AP. PKA: lessons learned after twenty years. Biochim Biophys Acta. 2013 Jul; 1834(7):1271-8. PMID: 23535202; PMCID: PMC3763834.
      55. Bastidas AC, Deal MS, Steichen JM, Guo Y, Wu J, Taylor S. Phosphoryl transfer by protein kinase A is captured in a crystal lattice. J Am Chem Soc. 2013 Mar 27; 135(12):4788-98. PMID: 23458248; PMCID: PMC3663052.
      56. Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King CC, Darshi M, Blumenthal DK, Ali SS, Roth DM, Patel HH, Taylor S. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E387-96. PMID: 23319652; PMCID: PMC3562788.
      57. Cembran A, Masterson LR, McClendon CL, Taylor S, Gao J, Veglia G. Conformational equilibrium of N-myristoylated cAMP-dependent protein kinase A by molecular dynamics simulations. Biochemistry. 2012 Dec 21; 51(51):10186-96. PMID: 23205665; PMCID: PMC3545707.
      58. Guo Y, Wilderman A, Zhang L, Taylor S, Insel PA. Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry. 2012 Nov 20; 51(46):9323-32. PMID: 23110364; PMCID: PMC3503394.
      59. Burgers PP, Ma Y, Margarucci L, Mackey M, van der Heyden MA, Ellisman M, Scholten A, Taylor S, Heck AJ. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. J Biol Chem. 2012 Dec 21; 287(52):43789-97. PMID: 23115245; PMCID: PMC3527963.
      60. Darshi M, Trinh KN, Murphy AN, Taylor S. Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. J Biol Chem. 2012 Nov 16; 287(47):39480-91. PMID: 23019327; PMCID: PMC3501047.
      61. Taylor S, Ilouz R, Zhang P, Kornev AP. Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol. 2012 Oct; 13(10):646-58. PMID: 22992589; PMCID: PMC3985763.
      62. Taylor S, Keshwani MM, Steichen JM, Kornev AP. Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19; 367(1602):2517-28. PMID: 22889904; PMCID: PMC3415842.
      63. Kükrer B, Barbu IM, Copps J, Hogan P, Taylor S, van Duijn E, Heck AJ. Conformational isomers of calcineurin follow distinct dissociation pathways. J Am Soc Mass Spectrom. 2012 Sep; 23(9):1534-43. PMID: 22811075; PMCID: PMC4120237.
      64. Ilouz R, Bubis J, Wu J, Yim YY, Deal MS, Kornev AP, Ma Y, Blumenthal DK, Taylor S. Localization and quaternary structure of the PKA RIß holoenzyme. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12443-8. PMID: 22797896; PMCID: PMC3411989.
      65. Haste NM, Talabani H, Doo A, Merckx A, Langsley G, Taylor S. Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target. Microbes Infect. 2012 Aug; 14(10):838-50. PMID: 22626931; PMCID: PMC3967591.
      66. Bastidas AC, Deal MS, Steichen JM, Keshwani MM, Guo Y, Taylor S. Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J Mol Biol. 2012 Sep 14; 422(2):215-29. PMID: 22617327; PMCID: PMC3597442.
      67. Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA, Taylor S. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1221-9. PMID: 22493239; PMCID: PMC3356610.
      68. Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, Taylor S. Structure and allostery of the PKA RIIß tetrameric holoenzyme. Science. 2012 Feb 10; 335(6069):712-6. PMID: 22323819; PMCID: PMC3985767.
      69. Steichen JM, Kuchinskas M, Keshwani MM, Yang J, Adams JA, Taylor S. Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem. 2012 Apr 27; 287(18):14672-80. PMID: 22334660; PMCID: PMC3340281.
      70. Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor S, Jennings PA, Newton AC. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. J Biol Chem. 2012 Apr 13; 287(16):13262-78. PMID: 22318721; PMCID: PMC3339987.
      71. Yang J, Wu J, Steichen JM, Kornev AP, Deal MS, Li S, Sankaran B, Woods VL, Taylor S. A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J Mol Biol. 2012 Jan 27; 415(4):666-79. PMID: 22138346; PMCID: PMC3445030.
      72. Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor S, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):E1227-35. PMID: 22084075; PMCID: PMC3228425.
      73. Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL, Kornev AP, Taylor S, Dostmann WR. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure. 2011 Sep 07; 19(9):1317-27. PMID: 21893290; PMCID: PMC3168983.
      74. Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor S. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). J Biol Chem. 2011 Jul 01; 286(26):23552-8. PMID: 21561857; PMCID: PMC3123118.
      75. King CC, Sastri M, Chang P, Pennypacker J, Taylor S. The rate of NF-?B nuclear translocation is regulated by PKA and A kinase interacting protein 1. PLoS One. 2011 Apr 27; 6(4):e18713. PMID: 21556136; PMCID: PMC3083391.
      76. Day ME, Gaietta GM, Sastri M, Koller A, Mackey MR, Scott JD, Perkins GA, Ellisman MH, Taylor S. Isoform-specific targeting of PKA to multivesicular bodies. J Cell Biol. 2011 Apr 18; 193(2):347-63. PMID: 21502359; PMCID: PMC3080257.
      77. Masterson LR, Shi L, Metcalfe E, Gao J, Taylor S, Veglia G. Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6969-74. PMID: 21471451; PMCID: PMC3084134.
      78. Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor S, Shaw AS. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6067-72. PMID: 21441104; PMCID: PMC3076888.
      79. Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA, Kornev AP, Taylor S. Realizing the allosteric potential of the tetrameric protein kinase A RIa holoenzyme. Structure. 2011 Feb 09; 19(2):265-76. PMID: 21300294; PMCID: PMC3097484.
      80. McLaughlin WA, Hou T, Taylor S, Wang W. The identification of novel cyclic AMP-dependent protein kinase anchoring proteins using bioinformatic filters and peptide arrays. Protein Eng Des Sel. 2011 Mar; 24(3):333-9. PMID: 21115539; PMCID: PMC3038459.
      81. Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins GA, Ellisman MH, Taylor S. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem. 2011 Jan 28; 286(4):2918-32. PMID: 21081504; PMCID: PMC3024787.
      82. Badireddy S, Yunfeng G, Ritchie M, Akamine P, Wu J, Kim CW, Taylor S, Qingsong L, Swaminathan K, Anand GS. Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design. Mol Cell Proteomics. 2011 Mar; 10(3):M110.004390. PMID: 21081668; PMCID: PMC3047156.
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      84. Taylor S, Kornev AP. Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci. 2011 Feb; 36(2):65-77. PMID: 20971646; PMCID: PMC3084033.
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      86. Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor S, Roth DM. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem. 2010 Sep 03; 285(36):27632-40. PMID: 20581396; PMCID: PMC2934631.
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      89. McNicholl ET, Das R, SilDas S, Taylor S, Melacini G. Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations. J Biol Chem. 2010 May 14; 285(20):15523-37. PMID: 20202931; PMCID: PMC2865341.
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      93. Khavrutskii IV, Grant B, Taylor S, McCammon JA. A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A. Biochemistry. 2009 Dec 08; 48(48):11532-45. PMID: 19886670; PMCID: PMC2789581.
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      97. Eggers CT, Schafer JC, Goldenring JR, Taylor S. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J Biol Chem. 2009 Nov 20; 284(47):32869-80. PMID: 19797056; PMCID: PMC2781703.
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      103. Gould CM, Kannan N, Taylor S, Newton AC. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem. 2009 Feb 20; 284(8):4921-35. PMID: 19091746; PMCID: PMC2643500.
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      105. Torkamani A, Kannan N, Taylor S, Schork NJ. Congenital disease SNPs target lineage specific structural elements in protein kinases. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):9011-6. PMID: 18579784; PMCID: PMC2449356.
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      115. Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor S, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE. The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol. 2007 Sep 24; 178(7):1265-78. PMID: 17893247; PMCID: PMC2064658.
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      120. Humphries KM, Pennypacker JK, Taylor S. Redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation. J Biol Chem. 2007 Jul 27; 282(30):22072-9. PMID: 17548350.
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      122. Lim CJ, Han J, Yousefi N, Ma Y, Amieux PS, McKnight GS, Taylor S, Ginsberg MH. Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol. 2007 Apr; 9(4):415-21. PMID: 17369818.
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      123. Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, Joachimiak MP, van Belle C, Chandonia JM, Soergel DA, Zhai Y, Natarajan K, Lee S, Raphael BJ, Bafna V, Friedman R, Brenner SE, Godzik A, Eisenberg D, Dixon JE, Taylor S, Strausberg RL, Frazier M, Venter JC. The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol. 2007 Mar; 5(3):e16. PMID: 17355171; PMCID: PMC1821046.
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      125. Schauble S, King CC, Darshi M, Koller A, Shah K, Taylor S. Identification of ChChd3 as a novel substrate of the cAMP-dependent protein kinase (PKA) using an analog-sensitive catalytic subunit. J Biol Chem. 2007 May 18; 282(20):14952-9. PMID: 17242405.
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      126. Kannan N, Haste N, Taylor S, Neuwald AF. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1272-7. PMID: 17227859; PMCID: PMC1783090.
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      137. Gullingsrud J, Kim C, Taylor S, McCammon JA. Dynamic binding of PKA regulatory subunit RI alpha. Structure. 2006 Jan; 14(1):141-9. PMID: 16407073.
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      139. Wu J, Yang J, Kannan N, Xuong NH, Ten Eyck LF, Taylor S. Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix. Protein Sci. 2005 Nov; 14(11):2871-9. PMID: 16253959; PMCID: PMC2253214.
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      147. Sastri M, Barraclough DM, Carmichael PT, Taylor S. A-kinase-interacting protein localizes protein kinase A in the nucleus. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):349-54. PMID: 15630084; PMCID: PMC544310.
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      152. Nolen B, Taylor S, Ghosh G. Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell. 2004 Sep 10; 15(5):661-75. PMID: 15350212.
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      155. Wu J, Jones JM, Nguyen-Huu X, Ten Eyck LF, Taylor S. Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP. Biochemistry. 2004 Jun 01; 43(21):6620-9. PMID: 15157095.
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      156. Vigil D, Blumenthal DK, Brown S, Taylor S, Trewhella J. Differential effects of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry. 2004 May 18; 43(19):5629-36. PMID: 15134437.
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      157. Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM, Taylor S, Trewhella J. Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions. J Mol Biol. 2004 Apr 09; 337(5):1183-94. PMID: 15046986.
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      159. Yang J, Ten Eyck LF, Xuong NH, Taylor S. Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism. J Mol Biol. 2004 Feb 13; 336(2):473-87. PMID: 14757059.
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      160. Akamine P, Brunton LL, Ou HD, Canaves JM, Xuong NH, Taylor S. Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. Biochemistry. 2004 Jan 13; 43(1):85-96. PMID: 14705934.
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      162. Gisler SM, Madjdpour C, Bacic D, Pribanic S, Taylor S, Biber J, Murer H. PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. Kidney Int. 2003 Nov; 64(5):1746-54. PMID: 14531807.
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      172. Brinen LS, Canaves JM, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kovarik JS, Kreusch A, Kuhn P, Lesley SA, McMullan D, McPhillips TM, Miller MA, Miller MD, Morse A, Moy K, Ouyang J, Robb A, Rodrigues K, Selby TL, Spraggon G, Stevens RC, van den Bedem H, Velasquez J, Vincent J, Wang X, West B, Wolf G, Taylor S, Hodgson KO, Wooley J, Wilson IA. Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 A resolution. Proteins. 2003 Feb 01; 50(2):371-4. PMID: 12486729.
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      181. Akamine P, Xuong NH, Taylor S. Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nat Struct Biol. 2002 Apr; 9(4):273-7. PMID: 11896404.
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