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Susan Taylor
Title
Professor
School
University of California, San Diego
Department
Pharmacology
Address
9500 Gilman Drive #0654
CA La Jolla 92093
Phone
858-534-3677
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Research
Research Activities and Funding
San Diego Center for Systems Biology: From Maps to Models
NIH/NIGMS
P50GM085764
Jul 1, 2008 - May 31, 2019
Role: Co-Investigator
ASSEMBLY OF SIGNALING NETWORKS
NIH/NIDDK
R13DK057994
Mar 20, 2000 - Feb 28, 2001
Role: Principal Investigator
PKA & PKC Targeting Mechanisms (Program Project)
NIH/NIDDK
P01DK054441
Dec 15, 1998 - Mar 31, 2018
Role: Principal Investigator
NATIONAL BIOMEDICAL COMPUTATION RESOURCE
NIH
P41RR008605
Apr 15, 1994 - Apr 30, 2014
Role: Co-Investigator
MOLECULAR BIOPHYSICS TRAINING PROGRAM
NIH/NIGMS
T32GM008326
Jul 1, 1989 - Jun 30, 2021
Role: Principal Investigator
IVEM and Image Analysis Resource
NIH/NCRR
P41RR004050
Dec 12, 1988 - Mar 31, 2014
Role: Co-Investigator
GORDON RESEARCH CONFERENCE ON SECOND MESSENGERS
NIH/NIGMS
R13GM036850
Jun 23, 1986 - May 31, 1987
Role: Principal Investigator
Assembly and regulation of dynamic PKA macromolecular signaling systems
NIH/NIGMS
R01GM034921
Sep 25, 1985 - May 31, 2018
Role: Principal Investigator
Protein Kinase - Primary Structure and cAMP Interaction
NIH/NIGMS
R01GM019301
May 1, 1978 - Nov 30, 2014
Role: Principal Investigator
PROTEIN KINASE: PRIMARY STRUCTURE AND CAMP INTERACTION
NIH/NIGMS
R37GM019301
May 1, 1978 - Apr 30, 2005
Role: Principal Investigator
Bibliographic
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can
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Hao Y, Canavan C,
Taylor S
, Maillard RA. Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers. Sci Rep. 2017 Sep 07; 7(1):10843. PMID: 28883488.
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PubMed
Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH,
Taylor S
, Perkins GA. Sub-mitochondrial localization of genetic-tagged MIB interacting partners: Mic19, Mic60 and Sam50. J Cell Sci. 2017 Aug 14. PMID: 28808085.
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PubMed
Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL, Kornev AP,
Taylor S
, Veglia G. A dynamic hydrophobic core orchestrates allostery in protein kinases. Sci Adv. 2017 Apr; 3(4):e1600663. PMID: 28435869.
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PubMed
P Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC, Kornev AP,
Taylor S
, Amaro RE. Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIa. Biochemistry. 2017 Mar 14; 56(10):1536-1545. PMID: 28221775.
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PubMed
Ilouz R, Lev-Ram V, Bushong EA, Stiles TL, Friedmann-Morvinski D, Douglas C, Goldberg G, Ellisman MH,
Taylor S
. Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain. Elife. 2017 Jan 12; 6. PMID: 28079521.
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PubMed
Meharena HS, Fan X, Ahuja LG, Keshwani MM, McClendon CL, Chen AM, Adams JA,
Taylor S
. Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases. PLoS Biol. 2016 Nov; 14(11):e2000127. PMID: 27902690.
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PubMed
Bruystens JG, Wu J, Fortezzo A, Del Rio J, Nielsen C, Blumenthal DK, Rock R, Stefan E,
Taylor S
. Structure of a PKA RIa Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J Mol Biol. 2016 Dec 04; 428(24 Pt B):4890-4904. PMID: 27825928.
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PubMed
Taylor S
, Minor K, Shmon CL, Shelton GD, Patterson EE, Mickelson JR. Border Collie Collapse: Owner Survey Results and Veterinary Description of Videotaped Episodes. J Am Anim Hosp Assoc. 2016 Nov/Dec; 52(6):364-370. PMID: 27685362.
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PubMed
Taylor S
, Shmon C, Su L, Epp T, Minor K, Mickelson J, Patterson E, Shelton GD. Evaluation of Dogs with Border Collie Collapse, Including Response to Two Standardized Strenuous Exercise Protocols. J Am Anim Hosp Assoc. 2016 Sep-Oct; 52(5):281-90. PMID: 27487345.
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PubMed
Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U,
Taylor S
, Stefan E. Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling. Proc Natl Acad Sci U S A. 2016 Jul 12; 113(28):7786-91. PMID: 27357676; PMCID: PMC4948347.
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PubMed
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PubMed Central
Burgers PP, Bruystens J, Burnley RJ, Nikolaev VO, Keshwani M, Wu J, Janssen BJ,
Taylor S
, Heck AJ, Scholten A. Structure of smAKAP and its regulation by PKA-mediated phosphorylation. FEBS J. 2016 Jun; 283(11):2132-48. PMID: 27028580; PMCID: PMC4980077 [Available on 06/01/17].
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PubMed
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PubMed Central
Kim J, Li G, Walters MA,
Taylor S
, Veglia G. Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A. Structure. 2016 Mar 01; 24(3):353-63. PMID: 26833386; PMCID: PMC4775281 [Available on 03/01/17].
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PubMed
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PubMed Central
Chávez-Vargas L, Adame-García SR, Cervantes-Villagrana RD, Castillo-Kauil A, Bruystens JG, Fukuhara S,
Taylor S
, Mochizuki N, Reyes-Cruz G, Vázquez-Prado J. Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING. J Biol Chem. 2016 Mar 18; 291(12):6182-99. PMID: 26797121; PMCID: PMC4813559 [Available on 03/18/17].
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PubMed
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PubMed Central
Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M,
Taylor S
, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. PMID: 26748707; PMCID: PMC4831919.
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PubMed
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PubMed Central
Akimoto M, McNicholl ET, Ramkissoon A, Moleschi K,
Taylor S
, Melacini G. Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIa. PLoS Biol. 2015; 13(11):e1002305. PMID: 26618408; PMCID: PMC4664472.
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PubMed
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PubMed Central
Kornev AP,
Taylor S
. Dynamics-Driven Allostery in Protein Kinases. Trends Biochem Sci. 2015 Nov; 40(11):628-47. PMID: 26481499; PMCID: PMC4630092 [Available on 11/01/16].
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PubMed
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PubMed Central
Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA,
Taylor S
. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12681-6. PMID: 26417071; PMCID: PMC4611605.
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PubMed
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PubMed Central
Antal CE, Callender JA, Kornev AP,
Taylor S
, Newton AC. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C ßII. Cell Rep. 2015 Aug 25; 12(8):1252-60. PMID: 26279568; PMCID: PMC4551583.
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PubMed
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PubMed Central
Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH,
Taylor S
. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015 Sep 01; 23(9):1563-72. PMID: 26278174; PMCID: PMC4558360.
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PubMed
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PubMed Central
Knape MJ, Ahuja LG, Bertinetti D, Burghardt NC, Zimmermann B,
Taylor S
, Herberg FW. Divalent Metal Ions Mg²? and Ca²? Have Distinct Effects on Protein Kinase A Activity and Regulation. ACS Chem Biol. 2015 Oct 16; 10(10):2303-15. PMID: 26200257; PMCID: PMC4714867 [Available on 10/16/16].
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PubMed
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PubMed Central
Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN,
Taylor S
, Insel PA. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. PMID: 26203188; PMCID: PMC4571978.
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PubMed
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PubMed Central
Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW,
Taylor S
. Single Turnover Autophosphorylation Cycle of the PKA RIIß Holoenzyme. PLoS Biol. 2015 Jul; 13(7):e1002192. PMID: 26158466; PMCID: PMC4497662.
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PubMed
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PubMed Central
Malmstrom RD, Kornev AP,
Taylor S
, Amaro RE. Allostery through the computational microscope: cAMP activation of a canonical signalling domain. Nat Commun. 2015 Jul 06; 6:7588. PMID: 26145448; PMCID: PMC4504738.
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PubMed
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PubMed Central
Li GC, Srivastava AK, Kim J,
Taylor S
, Veglia G. Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors. Biochemistry. 2015 Jul 07; 54(26):4042-9. PMID: 26030372; PMCID: PMC4498444.
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PubMed
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PubMed Central
Zhang P, Kornev AP, Wu J,
Taylor S
. Discovery of Allostery in PKA Signaling. Biophys Rev. 2015 Jun 01; 7(2):227-238. PMID: 26097522.
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PubMed
Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS,
Taylor S
, Molinolo AA, Gutkind JS. Inactivation of a Ga(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015 Jun; 17(6):793-803. PMID: 25961504; PMCID: PMC4449815.
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PubMed
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PubMed Central
Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL,
Taylor S
, Engler AJ, Yang J. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol. 2015 May; 17(5):678-88. PMID: 25893917; PMCID: PMC4452027.
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PubMed
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PubMed Central
Taylor S
, Shaw AS, Kannan N, Kornev AP. Integration of signaling in the kinome: Architecture and regulation of the aC Helix. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1567-74. PMID: 25891902; PMCID: PMC4577442 [Available on 10/01/16].
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PubMed Central
Mohanty S, Kennedy EJ, Herberg FW, Hui R,
Taylor S
, Langsley G, Kannan N. Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1575-85. PMID: 25847873; PMCID: PMC4577300 [Available on 10/01/16].
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PubMed Central
Kim J, Masterson LR, Cembran A, Verardi R, Shi L, Gao J,
Taylor S
, Veglia G. Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3716-21. PMID: 25775607; PMCID: PMC4378435.
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PubMed Central
McSkimming DI, Dastgheib S, Talevich E, Narayanan A, Katiyar S,
Taylor S
, Kochut K, Kannan N. ProKinO: a unified resource for mining the cancer kinome. Hum Mutat. 2015 Feb; 36(2):175-86. PMID: 25382819; PMCID: PMC4342772.
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PubMed
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PubMed Central
Sarma GN, Moody IS, Ilouz R, Phan RH, Sankaran B, Hall RA,
Taylor S
. D-AKAP2:PKA RII:PDZK1 ternary complex structure: insights from the nucleation of a polyvalent scaffold. Protein Sci. 2015 Jan; 24(1):105-16. PMID: 25348485; PMCID: PMC4282416.
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PubMed
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PubMed Central
Srivastava AK, McDonald LR, Cembran A, Kim J, Masterson LR, McClendon CL,
Taylor S
, Veglia G. Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling. Structure. 2014 Dec 02; 22(12):1735-43. PMID: 25458836; PMCID: PMC4255147.
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PubMed
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PubMed Central
Niyitegeka JM, Bastidas AC, Newman RH,
Taylor S
, Ongeri EM. Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury. Am J Physiol Renal Physiol. 2015 Jan 01; 308(1):F56-68. PMID: 25354939; PMCID: PMC4281694.
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PubMed
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PubMed Central
Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP,
Taylor S
, Shaw AS. Kinase regulation by hydrophobic spine assembly in cancer. Mol Cell Biol. 2015 Jan; 35(1):264-76. PMID: 25348715; PMCID: PMC4295384.
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PubMed
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PubMed Central
McClendon CL, Kornev AP, Gilson MK,
Taylor S
. Dynamic architecture of a protein kinase. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4623-31. PMID: 25319261; PMCID: PMC4217441.
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PubMed
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PubMed Central
Boras BW, Kornev A,
Taylor S
, McCulloch AD. Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIa activation in response to cAMP binding. J Biol Chem. 2014 Oct 24; 289(43):30040-51. PMID: 25202018; PMCID: PMC4208011.
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PubMed
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PubMed Central
Blumenthal DK, Copps J, Smith-Nguyen EV, Zhang P, Heller WT,
Taylor S
. The roles of the RIIß linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIß protein kinase A: a small angle x-ray and neutron scattering study. J Biol Chem. 2014 Oct 10; 289(41):28505-12. PMID: 25112875; PMCID: PMC4192500.
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PubMed
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PubMed Central
Bastidas AC, Wu J,
Taylor S
. Molecular features of product release for the PKA catalytic cycle. Biochemistry. 2015 Jan 13; 54(1):2-10. PMID: 25077557; PMCID: PMC4295794.
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PubMed
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PubMed Central
Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS,
Taylor S
, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J. Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol. 2014 Mar 31; 204(7):1083-6. PMID: 24687277; PMCID: PMC3971754.
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PubMed
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PubMed Central
Shaw AS, Kornev AP, Hu J, Ahuja LG,
Taylor S
. Kinases and pseudokinases: lessons from RAF. Mol Cell Biol. 2014 May; 34(9):1538-46. PMID: 24567368; PMCID: PMC3993607.
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PubMed
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PubMed Central
Akimoto M, Moleschi K, Boulton S, VanSchouwen B, Selvaratnam R,
Taylor S
, Melacini G. Allosteric linkers in cAMP signalling. Biochem Soc Trans. 2014 Feb; 42(1):139-44. PMID: 24450641.
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PubMed
Bruystens JG, Wu J, Fortezzo A, Kornev AP, Blumenthal DK,
Taylor S
. PKA RIa homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. Structure. 2014 Jan 07; 22(1):59-69. PMID: 24316401; PMCID: PMC3963464.
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PubMed
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PubMed Central
Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N,
Taylor S
, Kornev AP. Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol. 2013 Oct; 11(10):e1001680. PMID: 24143133; PMCID: PMC3797032.
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PubMed
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PubMed Central
Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK,
Taylor S
, Dillmann WH, Goldhaber JI, Ross RS. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. PMID: 24091324; PMCID: PMC3784521.
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PubMed Central
Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM,
Taylor S
. Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Mol Cell Proteomics. 2013 Dec; 12(12):3744-58. PMID: 24030101; PMCID: PMC3861721.
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PubMed Central
Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B,
Taylor S
. Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs. ACS Chem Biol. 2013 Oct 18; 8(10):2164-72. PMID: 23978166; PMCID: PMC3827627.
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PubMed
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PubMed Central
Bastidas AC, Pierce LC, Walker RC, Johnson DA,
Taylor S
. Influence of N-myristylation and ligand binding on the flexibility of the catalytic subunit of protein kinase A. Biochemistry. 2013 Sep 17; 52(37):6368-79. PMID: 24003983; PMCID: PMC3788587.
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PubMed Central
Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJ, Kornev AP,
Taylor S
, Shaw AS. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell. 2013 Aug 29; 154(5):1036-46. PMID: 23993095; PMCID: PMC3844432.
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PubMed Central
Akimoto M, Selvaratnam R, McNicholl ET, Verma G,
Taylor S
, Melacini G. Signaling through dynamic linkers as revealed by PKA. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14231-6. PMID: 23946424; PMCID: PMC3761587.
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PubMed Central
Taylor S
, Shaw A, Hu J, Meharena HS, Kornev A. Pseudokinases from a structural perspective. Biochem Soc Trans. 2013 Aug; 41(4):981-6. PMID: 23863167; PMCID: PMC4399968.
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PubMed Central
Laanemets K, Brandt B, Li J, Merilo E, Wang YF, Keshwani MM,
Taylor S
, Kollist H, Schroeder JI. Calcium-dependent and -independent stomatal signaling network and compensatory feedback control of stomatal opening via Ca2+ sensitivity priming. Plant Physiol. 2013 Oct; 163(2):504-13. PMID: 23766366; PMCID: PMC3793032.
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PubMed Central
Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D,
Taylor S
, Lai ZC, Guan KL. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev. 2013 Jun 01; 27(11):1223-32. PMID: 23752589; PMCID: PMC3690396.
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PubMed Central
Lee YS, Morinaga H, Kim JJ, Lagakos W,
Taylor S
, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. The fractalkine/CX3CR1 system regulates ß cell function and insulin secretion. Cell. 2013 Apr 11; 153(2):413-25. PMID: 23582329; PMCID: PMC3717389.
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PubMed Central
Taylor S
, Zhang P, Steichen JM, Keshwani MM, Kornev AP. PKA: lessons learned after twenty years. Biochim Biophys Acta. 2013 Jul; 1834(7):1271-8. PMID: 23535202; PMCID: PMC3763834.
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Bastidas AC, Deal MS, Steichen JM, Guo Y, Wu J,
Taylor S
. Phosphoryl transfer by protein kinase A is captured in a crystal lattice. J Am Chem Soc. 2013 Mar 27; 135(12):4788-98. PMID: 23458248; PMCID: PMC3663052.
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Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King CC, Darshi M, Blumenthal DK, Ali SS, Roth DM, Patel HH,
Taylor S
. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E387-96. PMID: 23319652; PMCID: PMC3562788.
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Cembran A, Masterson LR, McClendon CL,
Taylor S
, Gao J, Veglia G. Conformational equilibrium of N-myristoylated cAMP-dependent protein kinase A by molecular dynamics simulations. Biochemistry. 2012 Dec 21; 51(51):10186-96. PMID: 23205665; PMCID: PMC3545707.
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Guo Y, Wilderman A, Zhang L,
Taylor S
, Insel PA. Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry. 2012 Nov 20; 51(46):9323-32. PMID: 23110364; PMCID: PMC3503394.
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PubMed Central
Burgers PP, Ma Y, Margarucci L, Mackey M, van der Heyden MA, Ellisman M, Scholten A,
Taylor S
, Heck AJ. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. J Biol Chem. 2012 Dec 21; 287(52):43789-97. PMID: 23115245; PMCID: PMC3527963.
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Darshi M, Trinh KN, Murphy AN,
Taylor S
. Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. J Biol Chem. 2012 Nov 16; 287(47):39480-91. PMID: 23019327; PMCID: PMC3501047.
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PubMed Central
Taylor S
, Ilouz R, Zhang P, Kornev AP. Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol. 2012 Oct; 13(10):646-58. PMID: 22992589; PMCID: PMC3985763.
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PubMed Central
Taylor S
, Keshwani MM, Steichen JM, Kornev AP. Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19; 367(1602):2517-28. PMID: 22889904; PMCID: PMC3415842.
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Kükrer B, Barbu IM, Copps J, Hogan P,
Taylor S
, van Duijn E, Heck AJ. Conformational isomers of calcineurin follow distinct dissociation pathways. J Am Soc Mass Spectrom. 2012 Sep; 23(9):1534-43. PMID: 22811075; PMCID: PMC4120237.
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Ilouz R, Bubis J, Wu J, Yim YY, Deal MS, Kornev AP, Ma Y, Blumenthal DK,
Taylor S
. Localization and quaternary structure of the PKA RIß holoenzyme. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12443-8. PMID: 22797896; PMCID: PMC3411989.
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PubMed Central
Haste NM, Talabani H, Doo A, Merckx A, Langsley G,
Taylor S
. Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target. Microbes Infect. 2012 Aug; 14(10):838-50. PMID: 22626931; PMCID: PMC3967591.
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Bastidas AC, Deal MS, Steichen JM, Keshwani MM, Guo Y,
Taylor S
. Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J Mol Biol. 2012 Sep 14; 422(2):215-29. PMID: 22617327; PMCID: PMC3597442.
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Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA,
Taylor S
. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1221-9. PMID: 22493239; PMCID: PMC3356610.
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PubMed Central
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. RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B. Structure. 2004 Jun; 12(6):1057-65. PMID: 15274925.
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Wu J, Jones JM, Nguyen-Huu X, Ten Eyck LF,
Taylor S
. Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP. Biochemistry. 2004 Jun 01; 43(21):6620-9. PMID: 15157095.
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Vigil D, Blumenthal DK, Brown S,
Taylor S
, Trewhella J. Differential effects of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry. 2004 May 18; 43(19):5629-36. PMID: 15134437.
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Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM,
Taylor S
, Trewhella J. Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions. J Mol Biol. 2004 Apr 09; 337(5):1183-94. PMID: 15046986.
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Heller WT, Vigil D, Brown S, Blumenthal DK,
Taylor S
, Trewhella J. C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change. J Biol Chem. 2004 Apr 30; 279(18):19084-90. PMID: 14985329.
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Yang J, Ten Eyck LF, Xuong NH,
Taylor S
. Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism. J Mol Biol. 2004 Feb 13; 336(2):473-87. PMID: 14757059.
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Akamine P, Brunton LL, Ou HD, Canaves JM, Xuong NH,
Taylor S
. Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. Biochemistry. 2004 Jan 13; 43(1):85-96. PMID: 14705934.
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Zawadzki KM,
Taylor S
. cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP. J Biol Chem. 2004 Feb 20; 279(8):7029-36. PMID: 14625280.
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Gisler SM, Madjdpour C, Bacic D, Pribanic S,
Taylor S
, Biber J, Murer H. PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. Kidney Int. 2003 Nov; 64(5):1746-54. PMID: 14531807.
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Anand GS, Law D, Mandell JG, Snead AN, Tsigelny I,
Taylor S
, Ten Eyck LF, Komives EA. Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13264-9. PMID: 14583592; PMCID: PMC263775.
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PubMed Central
Zawadzki KM, Hamuro Y, Kim JS, Garrod S, Stranz DD,
Taylor S
, Woods VL. Dissecting interdomain communication within cAPK regulatory subunit type IIbeta using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS). Protein Sci. 2003 Sep; 12(9):1980-90. PMID: 12930997; PMCID: PMC2323995.
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PubMed Central
Banky P, Roy M, Newlon MG, Morikis D, Haste NM,
Taylor S
, Jennings PA. Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform. J Mol Biol. 2003 Jul 25; 330(5):1117-29. PMID: 12860132.
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Zawadzki KM, Pan CP, Barkley MD, Johnson D,
Taylor S
. Endogenous tryptophan residues of cAPK regulatory subunit type IIbeta reveal local variations in environments and dynamics. Proteins. 2003 Jun 01; 51(4):552-61. PMID: 12784214.
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Burns LL, Canaves JM, Pennypacker JK, Blumenthal DK,
Taylor S
. Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA. Biochemistry. 2003 May 20; 42(19):5754-63. PMID: 12741833.
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Hamuro Y, Zawadzki KM, Kim JS, Stranz DD,
Taylor S
, Woods VL. Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS). J Mol Biol. 2003 Apr 11; 327(5):1065-76. PMID: 12662931.
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Burns-Hamuro LL, Ma Y, Kammerer S, Reineke U, Self C, Cook C, Olson GL, Cantor CR, Braun A,
Taylor S
. Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4072-7. PMID: 12646696; PMCID: PMC153050.
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PubMed Central
Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM, Nelson MR, Sing CF, Cantor CR,
Taylor S
, Braun A. Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4066-71. PMID: 12646697; PMCID: PMC153049.
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PubMed Central
Akamine P, Wu J, Xuong NH, Ten Eyck LF,
Taylor S
. Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. J Mol Biol. 2003 Mar 14; 327(1):159-71. PMID: 12614615.
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Brinen LS, Canaves JM, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kovarik JS, Kreusch A, Kuhn P, Lesley SA, McMullan D, McPhillips TM, Miller MA, Miller MD, Morse A, Moy K, Ouyang J, Robb A, Rodrigues K, Selby TL, Spraggon G, Stevens RC, van den Bedem H, Velasquez J, Vincent J, Wang X, West B, Wolf G,
Taylor S
, Hodgson KO, Wooley J, Wilson IA. Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 A resolution. Proteins. 2003 Feb 01; 50(2):371-4. PMID: 12486729.
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Moore MJ, Adams JA,
Taylor S
. Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop. J Biol Chem. 2003 Mar 21; 278(12):10613-8. PMID: 12499371.
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Anand GS, Hughes CA, Jones JM,
Taylor S
, Komives EA. Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A. J Mol Biol. 2002 Oct 18; 323(2):377-86. PMID: 12381327.
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Moore MJ, Kanter JR, Jones KC,
Taylor S
. Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1. J Biol Chem. 2002 Dec 06; 277(49):47878-84. PMID: 12372837.
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Kuhn P, Lesley SA, Mathews II, Canaves JM, Brinen LS, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Hodgson KO, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kovarik JM, Kreusch AT, McMullan D, McPhillips TM, Miller MA, Miller M, Morse A, Moy K, Ouyang J, Robb A, Rodrigues K, Selby TL, Spraggon G, Stevens RC,
Taylor S
, van den Bedem H, Velasquez J, Vincent J, Wang X, West B, Wolf G, Wooley J, Wilson IA. Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins. 2002 Oct 01; 49(1):142-5. PMID: 12211025.
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Hamuro Y, Burns L, Canaves J, Hoffman R,
Taylor S
, Woods V. Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). J Mol Biol. 2002 Aug 23; 321(4):703-14. PMID: 12206784.
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Lesley SA, Kuhn P, Godzik A, Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J,
Taylor S
, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11664-9. PMID: 12193646; PMCID: PMC129326.
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PubMed Central
Humphries KM, Juliano C,
Taylor S
. Regulation of cAMP-dependent protein kinase activity by glutathionylation. J Biol Chem. 2002 Nov 08; 277(45):43505-11. PMID: 12189155.
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Ma Y,
Taylor S
. A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting. J Biol Chem. 2002 Jul 26; 277(30):27328-36. PMID: 11994283.
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Akamine P, Xuong NH,
Taylor S
. Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nat Struct Biol. 2002 Apr; 9(4):273-7. PMID: 11896404.
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Li F, Gangal M, Juliano C, Gorfain E,
Taylor S
, Johnson DA. Evidence for an internal entropy contribution to phosphoryl transfer: a study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase. J Mol Biol. 2002 Jan 18; 315(3):459-69. PMID: 11786025.
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Canaves JM,
Taylor S
. Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family. J Mol Evol. 2002 Jan; 54(1):17-29. PMID: 11734894.
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Taylor S
, Radzio-Andzelm E. Protein kinase inhibition: natural and synthetic variations on a theme. Curr Opin Chem Biol. 1997 Aug; 1(2):219-26. PMID: 9667861.
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Catalytic Domain
Cyclic AMP-Dependent Protein Kinases
Protein Kinases
Cyclic AMP
Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
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Insel, Paul
King, Charles
Kornev, Alexandr
Ilouz, Ronit
Ten Eyck, Lynn
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Brand, Cameron
Dennis, Edward
Joiner, William
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Shalapour, Shabnam
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