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    Susan Taylor

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address9500 Gilman Drive #0654
    CA La Jolla 92093
    Phone858-534-3677
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      San Diego Center for Systems Biology: From Maps to Models
      NIH/NIGMS P50GM085764Jul 1, 2008 - May 31, 2019
      Role: Co-Investigator
      ASSEMBLY OF SIGNALING NETWORKS
      NIH/NIDDK R13DK057994Mar 20, 2000 - Feb 28, 2001
      Role: Principal Investigator
      PKA & PKC Targeting Mechanisms (Program Project)
      NIH/NIDDK P01DK054441Dec 15, 1998 - Mar 31, 2018
      Role: Principal Investigator
      NATIONAL BIOMEDICAL COMPUTATION RESOURCE
      NIH P41RR008605Apr 15, 1994 - Apr 30, 2014
      Role: Co-Investigator
      MOLECULAR BIOPHYSICS TRAINING PROGRAM
      NIH/NIGMS T32GM008326Jul 1, 1989 - Jun 30, 2021
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator
      GORDON RESEARCH CONFERENCE ON SECOND MESSENGERS
      NIH/NIGMS R13GM036850Jun 23, 1986 - May 31, 1987
      Role: Principal Investigator
      Assembly and regulation of dynamic PKA macromolecular signaling systems
      NIH/NIGMS R01GM034921Sep 25, 1985 - May 31, 2018
      Role: Principal Investigator
      Protein Kinase - Primary Structure and cAMP Interaction
      NIH/NIGMS R01GM019301May 1, 1978 - Nov 30, 2014
      Role: Principal Investigator
      PROTEIN KINASE: PRIMARY STRUCTURE AND CAMP INTERACTION
      NIH/NIGMS R37GM019301May 1, 1978 - Apr 30, 2005
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hao Y, Canavan C, Taylor S, Maillard RA. Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers. Sci Rep. 2017 Sep 07; 7(1):10843. PMID: 28883488.
        View in: PubMed
      2. Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH, Taylor S, Perkins GA. Sub-mitochondrial localization of genetic-tagged MIB interacting partners: Mic19, Mic60 and Sam50. J Cell Sci. 2017 Aug 14. PMID: 28808085.
        View in: PubMed
      3. Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL, Kornev AP, Taylor S, Veglia G. A dynamic hydrophobic core orchestrates allostery in protein kinases. Sci Adv. 2017 Apr; 3(4):e1600663. PMID: 28435869.
        View in: PubMed
      4. P Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC, Kornev AP, Taylor S, Amaro RE. Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIa. Biochemistry. 2017 Mar 14; 56(10):1536-1545. PMID: 28221775.
        View in: PubMed
      5. Ilouz R, Lev-Ram V, Bushong EA, Stiles TL, Friedmann-Morvinski D, Douglas C, Goldberg G, Ellisman MH, Taylor S. Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain. Elife. 2017 Jan 12; 6. PMID: 28079521.
        View in: PubMed
      6. Meharena HS, Fan X, Ahuja LG, Keshwani MM, McClendon CL, Chen AM, Adams JA, Taylor S. Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases. PLoS Biol. 2016 Nov; 14(11):e2000127. PMID: 27902690.
        View in: PubMed
      7. Bruystens JG, Wu J, Fortezzo A, Del Rio J, Nielsen C, Blumenthal DK, Rock R, Stefan E, Taylor S. Structure of a PKA RIa Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J Mol Biol. 2016 Dec 04; 428(24 Pt B):4890-4904. PMID: 27825928.
        View in: PubMed
      8. Taylor S, Minor K, Shmon CL, Shelton GD, Patterson EE, Mickelson JR. Border Collie Collapse: Owner Survey Results and Veterinary Description of Videotaped Episodes. J Am Anim Hosp Assoc. 2016 Nov/Dec; 52(6):364-370. PMID: 27685362.
        View in: PubMed
      9. Taylor S, Shmon C, Su L, Epp T, Minor K, Mickelson J, Patterson E, Shelton GD. Evaluation of Dogs with Border Collie Collapse, Including Response to Two Standardized Strenuous Exercise Protocols. J Am Anim Hosp Assoc. 2016 Sep-Oct; 52(5):281-90. PMID: 27487345.
        View in: PubMed
      10. Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor S, Stefan E. Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling. Proc Natl Acad Sci U S A. 2016 Jul 12; 113(28):7786-91. PMID: 27357676; PMCID: PMC4948347.
        View in: PubMed, PubMed Central
      11. Burgers PP, Bruystens J, Burnley RJ, Nikolaev VO, Keshwani M, Wu J, Janssen BJ, Taylor S, Heck AJ, Scholten A. Structure of smAKAP and its regulation by PKA-mediated phosphorylation. FEBS J. 2016 Jun; 283(11):2132-48. PMID: 27028580; PMCID: PMC4980077 [Available on 06/01/17].
        View in: PubMed, PubMed Central
      12. Kim J, Li G, Walters MA, Taylor S, Veglia G. Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A. Structure. 2016 Mar 01; 24(3):353-63. PMID: 26833386; PMCID: PMC4775281 [Available on 03/01/17].
        View in: PubMed, PubMed Central
      13. Chávez-Vargas L, Adame-García SR, Cervantes-Villagrana RD, Castillo-Kauil A, Bruystens JG, Fukuhara S, Taylor S, Mochizuki N, Reyes-Cruz G, Vázquez-Prado J. Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING. J Biol Chem. 2016 Mar 18; 291(12):6182-99. PMID: 26797121; PMCID: PMC4813559 [Available on 03/18/17].
        View in: PubMed, PubMed Central
      14. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor S, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. PMID: 26748707; PMCID: PMC4831919.
        View in: PubMed, PubMed Central
      15. Akimoto M, McNicholl ET, Ramkissoon A, Moleschi K, Taylor S, Melacini G. Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIa. PLoS Biol. 2015; 13(11):e1002305. PMID: 26618408; PMCID: PMC4664472.
        View in: PubMed, PubMed Central
      16. Kornev AP, Taylor S. Dynamics-Driven Allostery in Protein Kinases. Trends Biochem Sci. 2015 Nov; 40(11):628-47. PMID: 26481499; PMCID: PMC4630092 [Available on 11/01/16].
        View in: PubMed, PubMed Central
      17. Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA, Taylor S. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12681-6. PMID: 26417071; PMCID: PMC4611605.
        View in: PubMed, PubMed Central
      18. Antal CE, Callender JA, Kornev AP, Taylor S, Newton AC. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C ßII. Cell Rep. 2015 Aug 25; 12(8):1252-60. PMID: 26279568; PMCID: PMC4551583.
        View in: PubMed, PubMed Central
      19. Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor S. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015 Sep 01; 23(9):1563-72. PMID: 26278174; PMCID: PMC4558360.
        View in: PubMed, PubMed Central
      20. Knape MJ, Ahuja LG, Bertinetti D, Burghardt NC, Zimmermann B, Taylor S, Herberg FW. Divalent Metal Ions Mg²? and Ca²? Have Distinct Effects on Protein Kinase A Activity and Regulation. ACS Chem Biol. 2015 Oct 16; 10(10):2303-15. PMID: 26200257; PMCID: PMC4714867 [Available on 10/16/16].
        View in: PubMed, PubMed Central
      21. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor S, Insel PA. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. PMID: 26203188; PMCID: PMC4571978.
        View in: PubMed, PubMed Central
      22. Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor S. Single Turnover Autophosphorylation Cycle of the PKA RIIß Holoenzyme. PLoS Biol. 2015 Jul; 13(7):e1002192. PMID: 26158466; PMCID: PMC4497662.
        View in: PubMed, PubMed Central
      23. Malmstrom RD, Kornev AP, Taylor S, Amaro RE. Allostery through the computational microscope: cAMP activation of a canonical signalling domain. Nat Commun. 2015 Jul 06; 6:7588. PMID: 26145448; PMCID: PMC4504738.
        View in: PubMed, PubMed Central
      24. Li GC, Srivastava AK, Kim J, Taylor S, Veglia G. Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors. Biochemistry. 2015 Jul 07; 54(26):4042-9. PMID: 26030372; PMCID: PMC4498444.
        View in: PubMed, PubMed Central
      25. Zhang P, Kornev AP, Wu J, Taylor S. Discovery of Allostery in PKA Signaling. Biophys Rev. 2015 Jun 01; 7(2):227-238. PMID: 26097522.
        View in: PubMed
      26. Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor S, Molinolo AA, Gutkind JS. Inactivation of a Ga(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015 Jun; 17(6):793-803. PMID: 25961504; PMCID: PMC4449815.
        View in: PubMed, PubMed Central
      27. Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor S, Engler AJ, Yang J. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol. 2015 May; 17(5):678-88. PMID: 25893917; PMCID: PMC4452027.
        View in: PubMed, PubMed Central
      28. Taylor S, Shaw AS, Kannan N, Kornev AP. Integration of signaling in the kinome: Architecture and regulation of the aC Helix. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1567-74. PMID: 25891902; PMCID: PMC4577442 [Available on 10/01/16].
        View in: PubMed, PubMed Central
      29. Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor S, Langsley G, Kannan N. Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1575-85. PMID: 25847873; PMCID: PMC4577300 [Available on 10/01/16].
        View in: PubMed, PubMed Central
      30. Kim J, Masterson LR, Cembran A, Verardi R, Shi L, Gao J, Taylor S, Veglia G. Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3716-21. PMID: 25775607; PMCID: PMC4378435.
        View in: PubMed, PubMed Central
      31. McSkimming DI, Dastgheib S, Talevich E, Narayanan A, Katiyar S, Taylor S, Kochut K, Kannan N. ProKinO: a unified resource for mining the cancer kinome. Hum Mutat. 2015 Feb; 36(2):175-86. PMID: 25382819; PMCID: PMC4342772.
        View in: PubMed, PubMed Central
      32. Sarma GN, Moody IS, Ilouz R, Phan RH, Sankaran B, Hall RA, Taylor S. D-AKAP2:PKA RII:PDZK1 ternary complex structure: insights from the nucleation of a polyvalent scaffold. Protein Sci. 2015 Jan; 24(1):105-16. PMID: 25348485; PMCID: PMC4282416.
        View in: PubMed, PubMed Central
      33. Srivastava AK, McDonald LR, Cembran A, Kim J, Masterson LR, McClendon CL, Taylor S, Veglia G. Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling. Structure. 2014 Dec 02; 22(12):1735-43. PMID: 25458836; PMCID: PMC4255147.
        View in: PubMed, PubMed Central
      34. Niyitegeka JM, Bastidas AC, Newman RH, Taylor S, Ongeri EM. Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury. Am J Physiol Renal Physiol. 2015 Jan 01; 308(1):F56-68. PMID: 25354939; PMCID: PMC4281694.
        View in: PubMed, PubMed Central
      35. Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor S, Shaw AS. Kinase regulation by hydrophobic spine assembly in cancer. Mol Cell Biol. 2015 Jan; 35(1):264-76. PMID: 25348715; PMCID: PMC4295384.
        View in: PubMed, PubMed Central
      36. McClendon CL, Kornev AP, Gilson MK, Taylor S. Dynamic architecture of a protein kinase. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4623-31. PMID: 25319261; PMCID: PMC4217441.
        View in: PubMed, PubMed Central
      37. Boras BW, Kornev A, Taylor S, McCulloch AD. Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIa activation in response to cAMP binding. J Biol Chem. 2014 Oct 24; 289(43):30040-51. PMID: 25202018; PMCID: PMC4208011.
        View in: PubMed, PubMed Central
      38. Blumenthal DK, Copps J, Smith-Nguyen EV, Zhang P, Heller WT, Taylor S. The roles of the RIIß linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIß protein kinase A: a small angle x-ray and neutron scattering study. J Biol Chem. 2014 Oct 10; 289(41):28505-12. PMID: 25112875; PMCID: PMC4192500.
        View in: PubMed, PubMed Central
      39. Bastidas AC, Wu J, Taylor S. Molecular features of product release for the PKA catalytic cycle. Biochemistry. 2015 Jan 13; 54(1):2-10. PMID: 25077557; PMCID: PMC4295794.
        View in: PubMed, PubMed Central
      40. Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor S, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J. Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol. 2014 Mar 31; 204(7):1083-6. PMID: 24687277; PMCID: PMC3971754.
        View in: PubMed, PubMed Central
      41. Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor S. Kinases and pseudokinases: lessons from RAF. Mol Cell Biol. 2014 May; 34(9):1538-46. PMID: 24567368; PMCID: PMC3993607.
        View in: PubMed, PubMed Central
      42. Akimoto M, Moleschi K, Boulton S, VanSchouwen B, Selvaratnam R, Taylor S, Melacini G. Allosteric linkers in cAMP signalling. Biochem Soc Trans. 2014 Feb; 42(1):139-44. PMID: 24450641.
        View in: PubMed
      43. Bruystens JG, Wu J, Fortezzo A, Kornev AP, Blumenthal DK, Taylor S. PKA RIa homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. Structure. 2014 Jan 07; 22(1):59-69. PMID: 24316401; PMCID: PMC3963464.
        View in: PubMed, PubMed Central
      44. Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor S, Kornev AP. Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol. 2013 Oct; 11(10):e1001680. PMID: 24143133; PMCID: PMC3797032.
        View in: PubMed, PubMed Central
      45. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor S, Dillmann WH, Goldhaber JI, Ross RS. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. PMID: 24091324; PMCID: PMC3784521.
        View in: PubMed, PubMed Central
      46. Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM, Taylor S. Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Mol Cell Proteomics. 2013 Dec; 12(12):3744-58. PMID: 24030101; PMCID: PMC3861721.
        View in: PubMed, PubMed Central
      47. Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B, Taylor S. Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs. ACS Chem Biol. 2013 Oct 18; 8(10):2164-72. PMID: 23978166; PMCID: PMC3827627.
        View in: PubMed, PubMed Central
      48. Bastidas AC, Pierce LC, Walker RC, Johnson DA, Taylor S. Influence of N-myristylation and ligand binding on the flexibility of the catalytic subunit of protein kinase A. Biochemistry. 2013 Sep 17; 52(37):6368-79. PMID: 24003983; PMCID: PMC3788587.
        View in: PubMed, PubMed Central
      49. Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJ, Kornev AP, Taylor S, Shaw AS. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell. 2013 Aug 29; 154(5):1036-46. PMID: 23993095; PMCID: PMC3844432.
        View in: PubMed, PubMed Central
      50. Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor S, Melacini G. Signaling through dynamic linkers as revealed by PKA. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14231-6. PMID: 23946424; PMCID: PMC3761587.
        View in: PubMed, PubMed Central
      51. Taylor S, Shaw A, Hu J, Meharena HS, Kornev A. Pseudokinases from a structural perspective. Biochem Soc Trans. 2013 Aug; 41(4):981-6. PMID: 23863167; PMCID: PMC4399968.
        View in: PubMed, PubMed Central
      52. Laanemets K, Brandt B, Li J, Merilo E, Wang YF, Keshwani MM, Taylor S, Kollist H, Schroeder JI. Calcium-dependent and -independent stomatal signaling network and compensatory feedback control of stomatal opening via Ca2+ sensitivity priming. Plant Physiol. 2013 Oct; 163(2):504-13. PMID: 23766366; PMCID: PMC3793032.
        View in: PubMed, PubMed Central
      53. Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor S, Lai ZC, Guan KL. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev. 2013 Jun 01; 27(11):1223-32. PMID: 23752589; PMCID: PMC3690396.
        View in: PubMed, PubMed Central
      54. Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. The fractalkine/CX3CR1 system regulates ß cell function and insulin secretion. Cell. 2013 Apr 11; 153(2):413-25. PMID: 23582329; PMCID: PMC3717389.
        View in: PubMed, PubMed Central
      55. Taylor S, Zhang P, Steichen JM, Keshwani MM, Kornev AP. PKA: lessons learned after twenty years. Biochim Biophys Acta. 2013 Jul; 1834(7):1271-8. PMID: 23535202; PMCID: PMC3763834.
        View in: PubMed, PubMed Central
      56. Bastidas AC, Deal MS, Steichen JM, Guo Y, Wu J, Taylor S. Phosphoryl transfer by protein kinase A is captured in a crystal lattice. J Am Chem Soc. 2013 Mar 27; 135(12):4788-98. PMID: 23458248; PMCID: PMC3663052.
        View in: PubMed, PubMed Central
      57. Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King CC, Darshi M, Blumenthal DK, Ali SS, Roth DM, Patel HH, Taylor S. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E387-96. PMID: 23319652; PMCID: PMC3562788.
        View in: PubMed, PubMed Central
      58. Cembran A, Masterson LR, McClendon CL, Taylor S, Gao J, Veglia G. Conformational equilibrium of N-myristoylated cAMP-dependent protein kinase A by molecular dynamics simulations. Biochemistry. 2012 Dec 21; 51(51):10186-96. PMID: 23205665; PMCID: PMC3545707.
        View in: PubMed, PubMed Central
      59. Guo Y, Wilderman A, Zhang L, Taylor S, Insel PA. Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry. 2012 Nov 20; 51(46):9323-32. PMID: 23110364; PMCID: PMC3503394.
        View in: PubMed, PubMed Central
      60. Burgers PP, Ma Y, Margarucci L, Mackey M, van der Heyden MA, Ellisman M, Scholten A, Taylor S, Heck AJ. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. J Biol Chem. 2012 Dec 21; 287(52):43789-97. PMID: 23115245; PMCID: PMC3527963.
        View in: PubMed, PubMed Central
      61. Darshi M, Trinh KN, Murphy AN, Taylor S. Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. J Biol Chem. 2012 Nov 16; 287(47):39480-91. PMID: 23019327; PMCID: PMC3501047.
        View in: PubMed, PubMed Central
      62. Taylor S, Ilouz R, Zhang P, Kornev AP. Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol. 2012 Oct; 13(10):646-58. PMID: 22992589; PMCID: PMC3985763.
        View in: PubMed, PubMed Central
      63. Taylor S, Keshwani MM, Steichen JM, Kornev AP. Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19; 367(1602):2517-28. PMID: 22889904; PMCID: PMC3415842.
        View in: PubMed, PubMed Central
      64. Kükrer B, Barbu IM, Copps J, Hogan P, Taylor S, van Duijn E, Heck AJ. Conformational isomers of calcineurin follow distinct dissociation pathways. J Am Soc Mass Spectrom. 2012 Sep; 23(9):1534-43. PMID: 22811075; PMCID: PMC4120237.
        View in: PubMed, PubMed Central
      65. Ilouz R, Bubis J, Wu J, Yim YY, Deal MS, Kornev AP, Ma Y, Blumenthal DK, Taylor S. Localization and quaternary structure of the PKA RIß holoenzyme. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12443-8. PMID: 22797896; PMCID: PMC3411989.
        View in: PubMed, PubMed Central
      66. Haste NM, Talabani H, Doo A, Merckx A, Langsley G, Taylor S. Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target. Microbes Infect. 2012 Aug; 14(10):838-50. PMID: 22626931; PMCID: PMC3967591.
        View in: PubMed, PubMed Central
      67. Bastidas AC, Deal MS, Steichen JM, Keshwani MM, Guo Y, Taylor S. Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J Mol Biol. 2012 Sep 14; 422(2):215-29. PMID: 22617327; PMCID: PMC3597442.
        View in: PubMed, PubMed Central
      68. Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA, Taylor S. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1221-9. PMID: 22493239; PMCID: PMC3356610.
        View in: PubMed, PubMed Central
      69. Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, Taylor S. Structure and allostery of the PKA RIIß tetrameric holoenzyme. Science. 2012 Feb 10; 335(6069):712-6. PMID: 22323819; PMCID: PMC3985767.
        View in: PubMed, PubMed Central
      70. Steichen JM, Kuchinskas M, Keshwani MM, Yang J, Adams JA, Taylor S. Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem. 2012 Apr 27; 287(18):14672-80. PMID: 22334660; PMCID: PMC3340281.
        View in: PubMed, PubMed Central
      71. Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor S, Jennings PA, Newton AC. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. J Biol Chem. 2012 Apr 13; 287(16):13262-78. PMID: 22318721; PMCID: PMC3339987.
        View in: PubMed, PubMed Central
      72. Yang J, Wu J, Steichen JM, Kornev AP, Deal MS, Li S, Sankaran B, Woods VL, Taylor S. A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J Mol Biol. 2012 Jan 27; 415(4):666-79. PMID: 22138346; PMCID: PMC3445030.
        View in: PubMed, PubMed Central
      73. Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor S, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):E1227-35. PMID: 22084075; PMCID: PMC3228425.
        View in: PubMed, PubMed Central
      74. Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL, Kornev AP, Taylor S, Dostmann WR. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure. 2011 Sep 07; 19(9):1317-27. PMID: 21893290; PMCID: PMC3168983.
        View in: PubMed, PubMed Central
      75. Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor S. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). J Biol Chem. 2011 Jul 01; 286(26):23552-8. PMID: 21561857; PMCID: PMC3123118.
        View in: PubMed, PubMed Central
      76. King CC, Sastri M, Chang P, Pennypacker J, Taylor S. The rate of NF-?B nuclear translocation is regulated by PKA and A kinase interacting protein 1. PLoS One. 2011 Apr 27; 6(4):e18713. PMID: 21556136; PMCID: PMC3083391.
        View in: PubMed, PubMed Central
      77. Day ME, Gaietta GM, Sastri M, Koller A, Mackey MR, Scott JD, Perkins GA, Ellisman MH, Taylor S. Isoform-specific targeting of PKA to multivesicular bodies. J Cell Biol. 2011 Apr 18; 193(2):347-63. PMID: 21502359; PMCID: PMC3080257.
        View in: PubMed, PubMed Central
      78. Masterson LR, Shi L, Metcalfe E, Gao J, Taylor S, Veglia G. Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6969-74. PMID: 21471451; PMCID: PMC3084134.
        View in: PubMed, PubMed Central
      79. Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor S, Shaw AS. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6067-72. PMID: 21441104; PMCID: PMC3076888.
        View in: PubMed, PubMed Central
      80. Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA, Kornev AP, Taylor S. Realizing the allosteric potential of the tetrameric protein kinase A RIa holoenzyme. Structure. 2011 Feb 09; 19(2):265-76. PMID: 21300294; PMCID: PMC3097484.
        View in: PubMed, PubMed Central
      81. McLaughlin WA, Hou T, Taylor S, Wang W. The identification of novel cyclic AMP-dependent protein kinase anchoring proteins using bioinformatic filters and peptide arrays. Protein Eng Des Sel. 2011 Mar; 24(3):333-9. PMID: 21115539; PMCID: PMC3038459.
        View in: PubMed, PubMed Central
      82. Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins GA, Ellisman MH, Taylor S. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem. 2011 Jan 28; 286(4):2918-32. PMID: 21081504; PMCID: PMC3024787.
        View in: PubMed, PubMed Central
      83. Badireddy S, Yunfeng G, Ritchie M, Akamine P, Wu J, Kim CW, Taylor S, Qingsong L, Swaminathan K, Anand GS. Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design. Mol Cell Proteomics. 2011 Mar; 10(3):M110.004390. PMID: 21081668; PMCID: PMC3047156.
        View in: PubMed, PubMed Central
      84. Rinaldi J, Wu J, Yang J, Ralston CY, Sankaran B, Moreno S, Taylor S. Structure of yeast regulatory subunit: a glimpse into the evolution of PKA signaling. Structure. 2010 Nov 10; 18(11):1471-82. PMID: 21070946; PMCID: PMC3435106.
        View in: PubMed, PubMed Central
      85. Taylor S, Kornev AP. Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci. 2011 Feb; 36(2):65-77. PMID: 20971646; PMCID: PMC3084033.
        View in: PubMed, PubMed Central
      86. Masterson LR, Cheng C, Yu T, Tonelli M, Kornev A, Taylor S, Veglia G. Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol. 2010 Nov; 6(11):821-8. PMID: 20890288; PMCID: PMC3487389.
        View in: PubMed, PubMed Central
      87. Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor S, Roth DM. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem. 2010 Sep 03; 285(36):27632-40. PMID: 20581396; PMCID: PMC2934631.
        View in: PubMed, PubMed Central
      88. Sjoberg TJ, Kornev AP, Taylor S. Dissecting the cAMP-inducible allosteric switch in protein kinase A RIalpha. Protein Sci. 2010 Jun; 19(6):1213-21. PMID: 20512974; PMCID: PMC2895245.
        View in: PubMed, PubMed Central
      89. Taylor S, Kornev AP. Yet another "active" pseudokinase, Erb3. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8047-8. PMID: 20421461; PMCID: PMC2889589.
        View in: PubMed, PubMed Central
      90. McNicholl ET, Das R, SilDas S, Taylor S, Melacini G. Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations. J Biol Chem. 2010 May 14; 285(20):15523-37. PMID: 20202931; PMCID: PMC2865341.
        View in: PubMed, PubMed Central
      91. Anand GS, Krishnamurthy S, Bishnoi T, Kornev A, Taylor S, Johnson DA. Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase. Mol Cell Proteomics. 2010 Oct; 9(10):2225-37. PMID: 20167947; PMCID: PMC2957725.
        View in: PubMed, PubMed Central
      92. Sarma GN, Kinderman FS, Kim C, von Daake S, Chen L, Wang BC, Taylor S. Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. Structure. 2010 Feb 10; 18(2):155-66. PMID: 20159461; PMCID: PMC3090270.
        View in: PubMed, PubMed Central
      93. Cheng CY, Yang J, Taylor S, Blumenthal DK. Sensing domain dynamics in protein kinase A-I{alpha} complexes by solution X-ray scattering. J Biol Chem. 2009 Dec 18; 284(51):35916-25. PMID: 19837668; PMCID: PMC2791020.
        View in: PubMed, PubMed Central
      94. Khavrutskii IV, Grant B, Taylor S, McCammon JA. A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A. Biochemistry. 2009 Dec 08; 48(48):11532-45. PMID: 19886670; PMCID: PMC2789581.
        View in: PubMed, PubMed Central
      95. Steichen JM, Iyer GH, Li S, Saldanha SA, Deal MS, Woods VL, Taylor S. Global consequences of activation loop phosphorylation on protein kinase A. J Biol Chem. 2010 Feb 05; 285(6):3825-32. PMID: 19965870; PMCID: PMC2823524.
        View in: PubMed, PubMed Central
      96. Kornev AP, Taylor S. Defining the conserved internal architecture of a protein kinase. Biochim Biophys Acta. 2010 Mar; 1804(3):440-4. PMID: 19879387; PMCID: PMC3435107.
        View in: PubMed, PubMed Central
      97. Thompson EE, Kornev AP, Kannan N, Kim C, Ten Eyck LF, Taylor S. Comparative surface geometry of the protein kinase family. Protein Sci. 2009 Oct; 18(10):2016-26. PMID: 19610074; PMCID: PMC2786965.
        View in: PubMed, PubMed Central
      98. Eggers CT, Schafer JC, Goldenring JR, Taylor S. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J Biol Chem. 2009 Nov 20; 284(47):32869-80. PMID: 19797056; PMCID: PMC2781703.
        View in: PubMed, PubMed Central
      99. Brown SH, Wu J, Kim C, Alberto K, Taylor S. Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures. J Mol Biol. 2009 Nov 13; 393(5):1070-82. PMID: 19748511; PMCID: PMC3435109.
        View in: PubMed, PubMed Central
      100. Romano RA, Kannan N, Kornev AP, Allison CJ, Taylor S. A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1. Protein Sci. 2009 Jul; 18(7):1486-97. PMID: 19530248; PMCID: PMC2775216.
        View in: PubMed, PubMed Central
      101. Kennedy EJ, Yang J, Pillus L, Taylor S, Ghosh G. Identifying critical non-catalytic residues that modulate protein kinase A activity. PLoS One. 2009; 4(3):e4746. PMID: 19270744; PMCID: PMC2650257.
        View in: PubMed, PubMed Central
      102. Kornev AP, Taylor S. Pseudokinases: functional insights gleaned from structure. Structure. 2009 Jan 14; 17(1):5-7. PMID: 19141276.
        View in: PubMed
      103. Yang J, Kennedy EJ, Wu J, Deal MS, Pennypacker J, Ghosh G, Taylor S. Contribution of non-catalytic core residues to activity and regulation in protein kinase A. J Biol Chem. 2009 Mar 06; 284(10):6241-8. PMID: 19122195; PMCID: PMC2649094.
        View in: PubMed, PubMed Central
      104. Gould CM, Kannan N, Taylor S, Newton AC. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem. 2009 Feb 20; 284(8):4921-35. PMID: 19091746; PMCID: PMC2643500.
        View in: PubMed, PubMed Central
      105. Kornev AP, Taylor S, Ten Eyck LF. A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14377-82. PMID: 18787129; PMCID: PMC2533684.
        View in: PubMed, PubMed Central
      106. Torkamani A, Kannan N, Taylor S, Schork NJ. Congenital disease SNPs target lineage specific structural elements in protein kinases. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):9011-6. PMID: 18579784; PMCID: PMC2449356.
        View in: PubMed, PubMed Central
      107. Kannan N, Taylor S. Rethinking pseudokinases. Cell. 2008 Apr 18; 133(2):204-5. PMID: 18423189.
        View in: PubMed
      108. Kornev AP, Taylor S, Ten Eyck LF. A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. PLoS Comput Biol. 2008 Apr 11; 4(4):e1000056. PMID: 18404204; PMCID: PMC2275311.
        View in: PubMed, PubMed Central
      109. Ma Y, Taylor S. A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1. J Biol Chem. 2008 Apr 25; 283(17):11743-51. PMID: 18287098; PMCID: PMC2431083.
        View in: PubMed, PubMed Central
      110. Masterson LR, Mascioni A, Traaseth NJ, Taylor S, Veglia G. Allosteric cooperativity in protein kinase A. Proc Natl Acad Sci U S A. 2008 Jan 15; 105(2):506-11. PMID: 18178622; PMCID: PMC2206566.
        View in: PubMed, PubMed Central
      111. Ten Eyck LF, Taylor S, Kornev AP. Conserved spatial patterns across the protein kinase family. Biochim Biophys Acta. 2008 Jan; 1784(1):238-43. PMID: 18067871.
        View in: PubMed
      112. Valiev M, Yang J, Adams JA, Taylor S, Weare JH. Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. J Phys Chem B. 2007 Nov 29; 111(47):13455-64. PMID: 17983217.
        View in: PubMed
      113. Wu J, Brown SH, von Daake S, Taylor S. PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. Science. 2007 Oct 12; 318(5848):274-9. PMID: 17932298; PMCID: PMC4036697.
        View in: PubMed, PubMed Central
      114. Taylor S, Kim C, Cheng CY, Brown SH, Wu J, Kannan N. Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochim Biophys Acta. 2008 Jan; 1784(1):16-26. PMID: 17996741; PMCID: PMC2561045.
        View in: PubMed, PubMed Central
      115. Kannan N, Neuwald AF, Taylor S. Analogous regulatory sites within the alphaC-beta4 loop regions of ZAP-70 tyrosine kinase and AGC kinases. Biochim Biophys Acta. 2008 Jan; 1784(1):27-32. PMID: 17977811; PMCID: PMC2259278.
        View in: PubMed, PubMed Central
      116. Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor S, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE. The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol. 2007 Sep 24; 178(7):1265-78. PMID: 17893247; PMCID: PMC2064658.
        View in: PubMed, PubMed Central
      117. Kim C, Cheng CY, Saldanha SA, Taylor S. PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell. 2007 Sep 21; 130(6):1032-43. PMID: 17889648.
        View in: PubMed
      118. Anand GS, Hotchko M, Brown SH, Ten Eyck LF, Komives EA, Taylor S. R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry. J Mol Biol. 2007 Nov 23; 374(2):487-99. PMID: 17942118; PMCID: PMC3419600.
        View in: PubMed, PubMed Central
      119. Martin BR, Deerinck TJ, Ellisman MH, Taylor S, Tsien RY. Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Chem Biol. 2007 Sep; 14(9):1031-42. PMID: 17884635.
        View in: PubMed
      120. Anand G, Taylor S, Johnson DA. Cyclic-AMP and pseudosubstrate effects on type-I A-kinase regulatory and catalytic subunit binding kinetics. Biochemistry. 2007 Aug 14; 46(32):9283-91. PMID: 17658893.
        View in: PubMed
      121. Humphries KM, Pennypacker JK, Taylor S. Redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation. J Biol Chem. 2007 Jul 27; 282(30):22072-9. PMID: 17548350.
        View in: PubMed
      122. Navarro L, Koller A, Nordfelth R, Wolf-Watz H, Taylor S, Dixon JE. Identification of a molecular target for the Yersinia protein kinase A. Mol Cell. 2007 May 25; 26(4):465-77. PMID: 17531806.
        View in: PubMed
      123. Lim CJ, Han J, Yousefi N, Ma Y, Amieux PS, McKnight GS, Taylor S, Ginsberg MH. Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol. 2007 Apr; 9(4):415-21. PMID: 17369818.
        View in: PubMed
      124. Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, Joachimiak MP, van Belle C, Chandonia JM, Soergel DA, Zhai Y, Natarajan K, Lee S, Raphael BJ, Bafna V, Friedman R, Brenner SE, Godzik A, Eisenberg D, Dixon JE, Taylor S, Strausberg RL, Frazier M, Venter JC. The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol. 2007 Mar; 5(3):e16. PMID: 17355171; PMCID: PMC1821046.
        View in: PubMed, PubMed Central
      125. Kannan N, Taylor S, Zhai Y, Venter JC, Manning G. Structural and functional diversity of the microbial kinome. PLoS Biol. 2007 Mar; 5(3):e17. PMID: 17355172; PMCID: PMC1821047.
        View in: PubMed, PubMed Central
      126. Schauble S, King CC, Darshi M, Koller A, Shah K, Taylor S. Identification of ChChd3 as a novel substrate of the cAMP-dependent protein kinase (PKA) using an analog-sensitive catalytic subunit. J Biol Chem. 2007 May 18; 282(20):14952-9. PMID: 17242405.
        View in: PubMed
      127. Kannan N, Haste N, Taylor S, Neuwald AF. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1272-7. PMID: 17227859; PMCID: PMC1783090.
        View in: PubMed, PubMed Central
      128. Kannan N, Wu J, Anand GS, Yooseph S, Neuwald AF, Venter JC, Taylor S. Evolution of allostery in the cyclic nucleotide binding module. Genome Biol. 2007; 8(12):R264. PMID: 18076763; PMCID: PMC2246266.
        View in: PubMed, PubMed Central
      129. Das R, Esposito V, Abu-Abed M, Anand GS, Taylor S, Melacini G. cAMP activation of PKA defines an ancient signaling mechanism. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):93-8. PMID: 17182741; PMCID: PMC1765484.
        View in: PubMed, PubMed Central
      130. Saldanha SA, Kaler G, Cottam HB, Abagyan R, Taylor S. Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. Anal Chem. 2006 Dec 15; 78(24):8265-72. PMID: 17165815; PMCID: PMC3435108.
        View in: PubMed, PubMed Central
      131. Kornev AP, Haste NM, Taylor S, Eyck LF. Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17783-8. PMID: 17095602; PMCID: PMC1693824.
        View in: PubMed, PubMed Central
      132. Kinderman FS, Kim C, von Daake S, Ma Y, Pham BQ, Spraggon G, Xuong NH, Jennings PA, Taylor S. A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell. 2006 Nov 03; 24(3):397-408. PMID: 17081990; PMCID: PMC1855097.
        View in: PubMed, PubMed Central
      133. Cranston AN, Carniti C, Oakhill K, Radzio-Andzelm E, Stone EA, McCallion AS, Hodgson S, Clarke S, Mondellini P, Leyland J, Pierotti MA, Whittaker J, Taylor S, Bongarzone I, Ponder BA. RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B. Cancer Res. 2006 Oct 15; 66(20):10179-87. PMID: 17047083.
        View in: PubMed
      134. Esposito V, Sjoberg T, Das R, Brown S, Taylor S, Melacini G. NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit. J Biomol NMR. 2006; 36 Suppl 1:64. PMID: 17016670.
        View in: PubMed
      135. Kim C, Vigil D, Anand G, Taylor S. Structure and dynamics of PKA signaling proteins. Eur J Cell Biol. 2006 Jul; 85(7):651-4. PMID: 16647784.
        View in: PubMed
      136. Niedner RH, Buzko OV, Haste NM, Taylor A, Gribskov M, Taylor S. Protein kinase resource: an integrated environment for phosphorylation research. Proteins. 2006 Apr 01; 63(1):78-86. PMID: 16435372.
        View in: PubMed
      137. Vigil D, Blumenthal DK, Taylor S, Trewhella J. Solution scattering reveals large differences in the global structures of type II protein kinase A isoforms. J Mol Biol. 2006 Mar 31; 357(3):880-9. PMID: 16460759.
        View in: PubMed
      138. Gullingsrud J, Kim C, Taylor S, McCammon JA. Dynamic binding of PKA regulatory subunit RI alpha. Structure. 2006 Jan; 14(1):141-9. PMID: 16407073.
        View in: PubMed
      139. Vigil D, Lin JH, Sotriffer CA, Pennypacker JK, McCammon JA, Taylor S. A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP. Protein Sci. 2006 Jan; 15(1):113-21. PMID: 16322564; PMCID: PMC2242374.
        View in: PubMed, PubMed Central
      140. Wu J, Yang J, Kannan N, Xuong NH, Ten Eyck LF, Taylor S. Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix. Protein Sci. 2005 Nov; 14(11):2871-9. PMID: 16253959; PMCID: PMC2253214.
        View in: PubMed, PubMed Central
      141. Burns-Hamuro LL, Hamuro Y, Kim JS, Sigala P, Fayos R, Stranz DD, Jennings PA, Taylor S, Woods VL. Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Protein Sci. 2005 Dec; 14(12):2982-92. PMID: 16260760; PMCID: PMC2253242.
        View in: PubMed, PubMed Central
      142. Taylor S, Haste NM, Ghosh G. PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking. Cell. 2005 Sep 23; 122(6):823-5. PMID: 16179248.
        View in: PubMed
      143. Taylor S, Kim C, Vigil D, Haste NM, Yang J, Wu J, Anand GS. Dynamics of signaling by PKA. Biochim Biophys Acta. 2005 Dec 30; 1754(1-2):25-37. PMID: 16214430.
        View in: PubMed
      144. Zhang J, Hupfeld CJ, Taylor S, Olefsky JM, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 2005 Sep 22; 437(7058):569-73. PMID: 16177793.
        View in: PubMed
      145. Iyer GH, Garrod S, Woods VL, Taylor S. Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase. J Mol Biol. 2005 Sep 02; 351(5):1110-22. PMID: 16054648.
        View in: PubMed
      146. Vigil D, Blumenthal DK, Taylor S, Trewhella J. The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding. J Biol Chem. 2005 Oct 21; 280(42):35521-7. PMID: 16109722.
        View in: PubMed
      147. Kim C, Xuong NH, Taylor S. Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science. 2005 Feb 04; 307(5710):690-6. PMID: 15692043.
        View in: PubMed
      148. Sastri M, Barraclough DM, Carmichael PT, Taylor S. A-kinase-interacting protein localizes protein kinase A in the nucleus. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):349-54. PMID: 15630084; PMCID: PMC544310.
        View in: PubMed, PubMed Central
      149. Berman HM, Ten Eyck LF, Goodsell DS, Haste NM, Kornev A, Taylor S. The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):45-50. PMID: 15618393; PMCID: PMC544069.
        View in: PubMed, PubMed Central
      150. Iyer GH, Moore MJ, Taylor S. Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase. J Biol Chem. 2005 Mar 11; 280(10):8800-7. PMID: 15618230.
        View in: PubMed
      151. Yang J, Garrod SM, Deal MS, Anand GS, Woods VL, Taylor S. Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop. J Mol Biol. 2005 Feb 11; 346(1):191-201. PMID: 15663937.
        View in: PubMed
      152. Humphries KM, Deal MS, Taylor S. Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification. J Biol Chem. 2005 Jan 28; 280(4):2750-8. PMID: 15533936.
        View in: PubMed
      153. Nolen B, Taylor S, Ghosh G. Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell. 2004 Sep 10; 15(5):661-75. PMID: 15350212.
        View in: PubMed
      154. Hamuro Y, Anand GS, Kim JS, Juliano C, Stranz DD, Taylor S, Woods VL. Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Mol Biol. 2004 Jul 23; 340(5):1185-96. PMID: 15236976.
        View in: PubMed
      155. Wu J, Brown S, Xuong NH, Taylor S. RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B. Structure. 2004 Jun; 12(6):1057-65. PMID: 15274925.
        View in: PubMed
      156. Wu J, Jones JM, Nguyen-Huu X, Ten Eyck LF, Taylor S. Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP. Biochemistry. 2004 Jun 01; 43(21):6620-9. PMID: 15157095.
        View in: PubMed
      157. Vigil D, Blumenthal DK, Brown S, Taylor S, Trewhella J. Differential effects of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry. 2004 May 18; 43(19):5629-36. PMID: 15134437.
        View in: PubMed
      158. Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM, Taylor S, Trewhella J. Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions. J Mol Biol. 2004 Apr 09; 337(5):1183-94. PMID: 15046986.
        View in: PubMed
      159. Heller WT, Vigil D, Brown S, Blumenthal DK, Taylor S, Trewhella J. C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change. J Biol Chem. 2004 Apr 30; 279(18):19084-90. PMID: 14985329.
        View in: PubMed
      160. Yang J, Ten Eyck LF, Xuong NH, Taylor S. Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism. J Mol Biol. 2004 Feb 13; 336(2):473-87. PMID: 14757059.
        View in: PubMed
      161. Akamine P, Brunton LL, Ou HD, Canaves JM, Xuong NH, Taylor S. Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. Biochemistry. 2004 Jan 13; 43(1):85-96. PMID: 14705934.
        View in: PubMed
      162. Zawadzki KM, Taylor S. cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP. J Biol Chem. 2004 Feb 20; 279(8):7029-36. PMID: 14625280.
        View in: PubMed
      163. Gisler SM, Madjdpour C, Bacic D, Pribanic S, Taylor S, Biber J, Murer H. PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. Kidney Int. 2003 Nov; 64(5):1746-54. PMID: 14531807.
        View in: PubMed
      164. Anand GS, Law D, Mandell JG, Snead AN, Tsigelny I, Taylor S, Ten Eyck LF, Komives EA. Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13264-9. PMID: 14583592; PMCID: PMC263775.
        View in: PubMed, PubMed Central
      165. Zawadzki KM, Hamuro Y, Kim JS, Garrod S, Stranz DD, Taylor S, Woods VL. Dissecting interdomain communication within cAPK regulatory subunit type IIbeta using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS). Protein Sci. 2003 Sep; 12(9):1980-90. PMID: 12930997; PMCID: PMC2323995.
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      166. Banky P, Roy M, Newlon MG, Morikis D, Haste NM, Taylor S, Jennings PA. Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform. J Mol Biol. 2003 Jul 25; 330(5):1117-29. PMID: 12860132.
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      167. Zawadzki KM, Pan CP, Barkley MD, Johnson D, Taylor S. Endogenous tryptophan residues of cAPK regulatory subunit type IIbeta reveal local variations in environments and dynamics. Proteins. 2003 Jun 01; 51(4):552-61. PMID: 12784214.
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      168. Burns LL, Canaves JM, Pennypacker JK, Blumenthal DK, Taylor S. Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA. Biochemistry. 2003 May 20; 42(19):5754-63. PMID: 12741833.
        View in: PubMed
      169. Hamuro Y, Zawadzki KM, Kim JS, Stranz DD, Taylor S, Woods VL. Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS). J Mol Biol. 2003 Apr 11; 327(5):1065-76. PMID: 12662931.
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      170. Burns-Hamuro LL, Ma Y, Kammerer S, Reineke U, Self C, Cook C, Olson GL, Cantor CR, Braun A, Taylor S. Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4072-7. PMID: 12646696; PMCID: PMC153050.
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      171. Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM, Nelson MR, Sing CF, Cantor CR, Taylor S, Braun A. Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4066-71. PMID: 12646697; PMCID: PMC153049.
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      172. Akamine P, Wu J, Xuong NH, Ten Eyck LF, Taylor S. Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. J Mol Biol. 2003 Mar 14; 327(1):159-71. PMID: 12614615.
        View in: PubMed
      173. Brinen LS, Canaves JM, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kovarik JS, Kreusch A, Kuhn P, Lesley SA, McMullan D, McPhillips TM, Miller MA, Miller MD, Morse A, Moy K, Ouyang J, Robb A, Rodrigues K, Selby TL, Spraggon G, Stevens RC, van den Bedem H, Velasquez J, Vincent J, Wang X, West B, Wolf G, Taylor S, Hodgson KO, Wooley J, Wilson IA. Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 A resolution. Proteins. 2003 Feb 01; 50(2):371-4. PMID: 12486729.
        View in: PubMed
      174. Moore MJ, Adams JA, Taylor S. Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop. J Biol Chem. 2003 Mar 21; 278(12):10613-8. PMID: 12499371.
        View in: PubMed
      175. Anand GS, Hughes CA, Jones JM, Taylor S, Komives EA. Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A. J Mol Biol. 2002 Oct 18; 323(2):377-86. PMID: 12381327.
        View in: PubMed
      176. Moore MJ, Kanter JR, Jones KC, Taylor S. Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1. J Biol Chem. 2002 Dec 06; 277(49):47878-84. PMID: 12372837.
        View in: PubMed
      177. Kuhn P, Lesley SA, Mathews II, Canaves JM, Brinen LS, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Hodgson KO, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kovarik JM, Kreusch AT, McMullan D, McPhillips TM, Miller MA, Miller M, Morse A, Moy K, Ouyang J, Robb A, Rodrigues K, Selby TL, Spraggon G, Stevens RC, Taylor S, van den Bedem H, Velasquez J, Vincent J, Wang X, West B, Wolf G, Wooley J, Wilson IA. Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins. 2002 Oct 01; 49(1):142-5. PMID: 12211025.
        View in: PubMed
      178. Hamuro Y, Burns L, Canaves J, Hoffman R, Taylor S, Woods V. Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). J Mol Biol. 2002 Aug 23; 321(4):703-14. PMID: 12206784.
        View in: PubMed
      179. Lesley SA, Kuhn P, Godzik A, Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor S, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11664-9. PMID: 12193646; PMCID: PMC129326.
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      180. Humphries KM, Juliano C, Taylor S. Regulation of cAMP-dependent protein kinase activity by glutathionylation. J Biol Chem. 2002 Nov 08; 277(45):43505-11. PMID: 12189155.
        View in: PubMed
      181. Ma Y, Taylor S. A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting. J Biol Chem. 2002 Jul 26; 277(30):27328-36. PMID: 11994283.
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      182. Akamine P, Xuong NH, Taylor S. Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nat Struct Biol. 2002 Apr; 9(4):273-7. PMID: 11896404.
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      183. Li F, Gangal M, Juliano C, Gorfain E, Taylor S, Johnson DA. Evidence for an internal entropy contribution to phosphoryl transfer: a study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase. J Mol Biol. 2002 Jan 18; 315(3):459-69. PMID: 11786025.
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      184. Canaves JM, Taylor S. Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family. J Mol Evol. 2002 Jan; 54(1):17-29. PMID: 11734894.
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      185. Taylor S, Radzio-Andzelm E. Protein kinase inhibition: natural and synthetic variations on a theme. Curr Opin Chem Biol. 1997 Aug; 1(2):219-26. PMID: 9667861.
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