Susan Powell

Title(s)Adjunct Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Dr. Powell received her BA degree with honors in Psychology from the University of North Carolina at Chapel Hill and her PhD in Behavioral Neuroscience from the University of Florida. She completed her postdoctoral training in psychopharmacology in the UCSD Psychiatry Department. She is currently a Professor in the Department of Psychiatry at UCSD and a Research Scientist at the Veterans Affairs San Diego Healthcare System. She has been the principal investigator on research awards from NIMH, NIEHS, and NARSAD. Dr. Powell’s career has focused on the translational interface of animal and human neurodevelopmental research. Her research examines early risk factors contributing to neurodevelopmental disorders such as schizophrenia and autism. Studies seek to determine the effects of environmental exposures and their combination with genetic susceptibility on genome-wide DNA methylation and behavior in mice. Her research also involves basic studies on the behavioral effects of hallucinogens in rodents with the hope that these models will inform us about psychosis in humans and lead to development of novel therapeutics for individuals with schizophrenia.

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    Impact of social isolation on cognitive function and neural circuitry abnormalities
    NIH I01BX005209Oct 1, 2020 - Sep 30, 2024
    Role: Principal Investigator
    Neural Circuitry of Repetitive Behavior
    NIH R21MH122838Apr 1, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Neural Circuitry of Repetitive Behavior
    NIH/NIMH RF1MH122838Apr 1, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Environmental contribution to neuronal-methylome dynamics in animal models of autism spectrum disorders
    NIH R01ES025585Aug 1, 2015 - Jun 30, 2021
    Role: Co-Principal Investigator
    Sensitive and Treatable Periods of Brain-Redox Imbalance in Schizophrenia
    NIH R01MH091407Jul 19, 2010 - May 31, 2016
    Role: Co-Principal Investigator
    Models of Antipsychotic Prophylaxis for Schizophrenia
    NIH R21MH068611Aug 8, 2003 - Jun 30, 2007
    Role: Principal Investigator
    STRESS RESPONSIVENESS IN ABNORMAL REPETITIVE BEHAVIOR
    NIH F31MH012175Aug 24, 1998
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. The Relevance of Animal Models of Social Isolation and Social Motivation for Understanding Schizophrenia: Review and Future Directions. Schizophr Bull. 2023 09 07; 49(5):1112-1126. Powell SB, Swerdlow NR. PMID: 37527471; PMCID: PMC10483472.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    2. Postnatal Phencyclidine-Induced Deficits in Decision Making Are Ameliorated by Optogenetic Inhibition of Ventromedial Orbitofrontal Cortical Glutamate Neurons. Biol Psychiatry Glob Open Sci. 2024 Jan; 4(1):264-274. Tranter MM, Faget L, Hnasko TS, Powell SB, Dillon DG, Barnes SA. PMID: 38298783; PMCID: PMC10829674.
      View in: PubMed   Mentions:
    3. Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model. Int J Mol Sci. 2023 Feb 20; 24(4). Lai JI, Porcu A, Romoli B, Keisler M, Manfredsson FP, Powell SB, Dulcis D. PMID: 36835612; PMCID: PMC9960650.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3. Elife. 2022 05 23; 11. Li J, Pinto-Duarte A, Zander M, Cuoco MS, Lai CY, Osteen J, Fang L, Luo C, Lucero JD, Gomez-Castanon R, Nery JR, Silva-Garcia I, Pang Y, Sejnowski TJ, Powell SB, Ecker JR, Mukamel EA, Behrens MM. PMID: 35604009; PMCID: PMC9170249.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. Correction: GRK3 deficiency elicits brain immune activation and psychosis. Mol Psychiatry. 2022 Mar; 27(3):1855. Sellgren CM, Imbeault S, Larsson MK, Oliveros A, Nilsson IAK, Codeluppi S, Orhan F, Bhat M, Tufvesson-Alm M, Gracias J, Kegel ME, Zheng Y, Faka A, Svedberg M, Powell SB, Caldwell S, Kamenski ME, Vawter MP, Schulmann A, Goiny M, Svensson CI, Hökfelt T, Schalling M, Schwieler L, Cervenka S, Choi DS, Landén M, Engberg G, Erhardt S. PMID: 34744164; PMCID: PMC9119248.
      View in: PubMed   Mentions:    Fields:    
    6. MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV. Psychiatry Res Neuroimaging. 2022 04; 321:111445. Young JW, Barback CV, Stolz LA, Groman SM, Vera DR, Hoh C, Kotta KK, Minassian A, Powell SB, Brody AL. PMID: 35101828.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    7. Evaluation of neurotoxicity and long-term function and behavior following intrathecal 1 % 2-chloroprocaine in juvenile rats. Neurotoxicology. 2022 01; 88:155-167. Walker SM, Malkmus S, Eddinger K, Steinauer J, Roberts AJ, Shubayev VI, Grafe MR, Powell SB, Yaksh TL. PMID: 34801587.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    8. Chronic presence of blood circulating anti-NMDAR1 autoantibodies impairs cognitive function in mice. PLoS One. 2021; 16(9):e0256972. Yue W, Caldwell S, Risbrough V, Powell S, Zhou X. PMID: 34473764; PMCID: PMC8412244.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    9. Dissociable impact of childhood trauma and deployment trauma on affective modulation of startle. Neurobiol Stress. 2021 Nov; 15:100362. Stout DM, Powell S, Kangavary A, Acheson DT, Nievergelt CM, Kash T, Simmons AN, Baker DG, Risbrough VB. PMID: 34258336; PMCID: PMC8259305.
      View in: PubMed   Mentions: 4  
    10. GRK3 deficiency elicits brain immune activation and psychosis. Mol Psychiatry. 2021 11; 26(11):6820-6832. Sellgren CM, Imbeault S, Larsson MK, Oliveros A, Nilsson IAK, Codeluppi S, Orhan F, Bhat M, Tufvesson-Alm M, Gracias J, Kegel ME, Zheng Y, Faka A, Svedberg M, Powell SB, Caldwell S, Kamenski ME, Vawter MP, Schulmann A, Goiny M, Svensson CI, Hökfelt T, Schalling M, Schwieler L, Cervenka S, Choi DS, Landén M, Engberg G, Erhardt S. PMID: 33976392; PMCID: PMC8760053.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    11. C-Reactive Protein: Marker of risk for post-traumatic stress disorder and its potential for a mechanistic role in trauma response and recovery. Eur J Neurosci. 2022 05; 55(9-10):2297-2310. Friend SF, Nachnani R, Powell SB, Risbrough VB. PMID: 33131159; PMCID: PMC8087722.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    12. Acute serotonin 2A receptor activation impairs behavioral flexibility in mice. Behav Brain Res. 2020 10 01; 395:112861. Amodeo DA, Hassan O, Klein L, Halberstadt AL, Powell SB. PMID: 32814148.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    13. Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex. Neurobiol Dis. 2019 05; 125:211-218. Amodeo DA, Lai CY, Hassan O, Mukamel EA, Behrens MM, Powell SB. PMID: 30716470; PMCID: PMC6474674.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    14. Role of Toll-like receptor 4 signaling in mast cell-mediated migraine pain pathway. Mol Pain. 2019 Jan-Dec; 15:1744806919867842. Ramachandran R, Wang Z, Saavedra C, DiNardo A, Corr M, Powell SB, Yaksh TL. PMID: 31342858; PMCID: PMC6688145.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    15. Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen. Psychopharmacology (Berl). 2019 Feb; 236(2):821-830. Halberstadt AL, van der Zee JVF, Chatha M, Geyer MA, Powell SB. PMID: 30448990; PMCID: PMC6778591.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    16. Structural Analysis of Hippocampal Kinase Signal Transduction. ACS Chem Neurosci. 2018 12 19; 9(12):3072-3085. McClatchy DB, Yu NK, Martínez-Bartolomé S, Patel R, Pelletier AR, Lavalle-Adam M, Powell SB, Roberto M, Yates JR. PMID: 30053369; PMCID: PMC6374210.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Phencyclidine increased while isolation rearing did not affect progressive ratio responding in rats: Investigating potential models of amotivation in schizophrenia. Behav Brain Res. 2019 05 17; 364:413-422. Amitai N, Powell SB, Young JW. PMID: 29175446.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    18. Sensorimotor gating deficits in "two-hit" models of schizophrenia risk factors. Schizophr Res. 2018 08; 198:68-83. Khan A, Powell SB. PMID: 29070440; PMCID: PMC5911431.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    19. Immune signaling mechanisms of PTSD risk and symptom development: insights from animal models. Curr Opin Behav Sci. 2017 Apr; 14:123-132. Deslauriers J, Powell S, Risbrough VB. PMID: 28758144; PMCID: PMC5525319.
      View in: PubMed   Mentions: 25  
    20. Effects of LPS-induced immune activation prior to trauma exposure on PTSD-like symptoms in mice. Behav Brain Res. 2017 04 14; 323:117-123. Deslauriers J, van Wijngaarde M, Geyer MA, Powell S, Risbrough VB. PMID: 28159589.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    21. Adolescent GBR12909 exposure induces oxidative stress, disrupts parvalbumin-positive interneurons, and leads to hyperactivity and impulsivity in adult mice. Neuroscience. 2017 03 14; 345:166-175. Khan A, de Jong LA, Kamenski ME, Higa KK, Lucero JD, Young JW, Behrens MM, Powell SB. PMID: 27890827; PMCID: PMC5316310.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. Effects of the psychotomimetic benzomorphan N-allylnormetazocine (SKF 10,047) on prepulse inhibition of startle in mice. Pharmacol Biochem Behav. 2016 09; 148:69-75. Halberstadt AL, Hyun J, Ruderman MA, Powell SB. PMID: 27236030; PMCID: PMC5662292.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    23. The novel ketamine analog methoxetamine produces dissociative-like behavioral effects in rodents. Psychopharmacology (Berl). 2016 Apr; 233(7):1215-25. Halberstadt AL, Slepak N, Hyun J, Buell MR, Powell SB. PMID: 26758284; PMCID: PMC5403250.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    24. Modeling neurodevelopmental cognitive deficits in tasks with cross-species translational validity. Genes Brain Behav. 2016 Jan; 15(1):27-44. Cope ZA, Powell SB, Young JW. PMID: 26667374; PMCID: PMC4961087.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    25. Negative visuospatial priming in isolation-reared rats: Evidence of resistance to the disruptive effects of amphetamine. Cogn Affect Behav Neurosci. 2015 Dec; 15(4):901-14. Amitai N, Powell S, Weber M, Swerdlow NR, Young JW. PMID: 26220402; PMCID: PMC4641795.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    26. Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice. Int J Neuropsychopharmacol. 2015 Jun 02; 18(11):pyv063. Higa KK, Ji B, Buell MR, Risbrough VB, Powell SB, Young JW, Geyer MA, Zhou X. PMID: 26037489; PMCID: PMC4756721.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    27. Early Adolescent Emergence of Reversal Learning Impairments in Isolation-Reared Rats. Dev Neurosci. 2015; 37(3):253-62. Powell SB, Khan A, Young JW, Scott CN, Buell MR, Caldwell S, Tsan E, de Jong LA, Acheson DT, Lucero J, Geyer MA, Behrens MM. PMID: 26022788; PMCID: PMC4644772.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    28. Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model. Mol Autism. 2015; 6:1. Naviaux JC, Wang L, Li K, Bright AT, Alaynick WA, Williams KR, Powell SB, Naviaux RK. PMID: 25705365; PMCID: PMC4334917.
      View in: PubMed   Mentions: 43     Fields:    
    29. Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy. Transl Psychiatry. 2014 Jun 17; 4:e400. Naviaux JC, Schuchbauer MA, Li K, Wang L, Risbrough VB, Powell SB, Naviaux RK. PMID: 24937094; PMCID: PMC4080315.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    30. Isolation rearing effects on probabilistic learning and cognitive flexibility in rats. Cogn Affect Behav Neurosci. 2014 Mar; 14(1):388-406. Amitai N, Young JW, Higa K, Sharp RF, Geyer MA, Powell SB. PMID: 23943516; PMCID: PMC3923850.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    31. Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid. Brain Behav Immun. 2014 Feb; 36:80-9. Liu XC, Holtze M, Powell SB, Terrando N, Larsson MK, Persson A, Olsson SK, Orhan F, Kegel M, Asp L, Goiny M, Schwieler L, Engberg G, Karlsson H, Erhardt S. PMID: 24140727; PMCID: PMC3947209.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    32. Forebrain gene expression predicts deficits in sensorimotor gating after isolation rearing in male rats. Behav Brain Res. 2013 Nov 15; 257:118-28. Swerdlow NR, Light GA, Trim RS, Breier MR, Hines SR, Powell SB. PMID: 24076151; PMCID: PMC3897308.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    33. Coupling of gene expression in medial prefrontal cortex and nucleus accumbens after neonatal ventral hippocampal lesions accompanies deficits in sensorimotor gating and auditory processing in rats. Neuropharmacology. 2013 Dec; 75:38-46. Swerdlow NR, Powell SB, Breier MR, Hines SR, Light GA. PMID: 23810830; PMCID: PMC3825835.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    34. Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model. PLoS One. 2013; 8(3):e57380. Naviaux RK, Zolkipli Z, Wang L, Nakayama T, Naviaux JC, Le TP, Schuchbauer MA, Rogac M, Tang Q, Dugan LL, Powell SB. PMID: 23516405; PMCID: PMC3596371.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    35. Role of the 5-HT₂A receptor in the locomotor hyperactivity produced by phenylalkylamine hallucinogens in mice. Neuropharmacology. 2013 Jul; 70:218-27. Halberstadt AL, Powell SB, Geyer MA. PMID: 23376711; PMCID: PMC3934507.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    36. Sensory and sensorimotor gating deficits after neonatal ventral hippocampal lesions in rats. Dev Neurosci. 2012; 34(2-3):240-9. Swerdlow NR, Light GA, Breier MR, Shoemaker JM, Saint Marie RL, Neary AC, Geyer MA, Stevens KE, Powell SB. PMID: 22572564.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    37. Genetic models of sensorimotor gating: relevance to neuropsychiatric disorders. Curr Top Behav Neurosci. 2012; 12:251-318. Powell SB, Weber M, Geyer MA. PMID: 22367921; PMCID: PMC3357439.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    38. Mouse pharmacological models of cognitive disruption relevant to schizophrenia. Neuropharmacology. 2012 Mar; 62(3):1381-90. Young JW, Powell SB, Geyer MA. PMID: 21726569; PMCID: PMC3217063.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    39. The effect of reduced dopamine D4 receptor expression in the 5-choice continuous performance task: Separating response inhibition from premature responding. Behav Brain Res. 2011 Sep 12; 222(1):183-92. Young JW, Powell SB, Scott CN, Zhou X, Geyer MA. PMID: 21458500; PMCID: PMC3531561.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    40. Behavioral and neurochemical consequences of cortical oxidative stress on parvalbumin-interneuron maturation in rodent models of schizophrenia. Neuropharmacology. 2012 Mar; 62(3):1322-31. Powell SB, Sejnowski TJ, Behrens MM. PMID: 21315745; PMCID: PMC3106123.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    41. Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in mice. Psychopharmacology (Berl). 2011 May; 215(1):81-92. Halberstadt AL, Lehmann-Masten VD, Geyer MA, Powell SB. PMID: 21153406; PMCID: PMC3072483.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    42. Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice. J Psychopharmacol. 2011 Nov; 25(11):1548-61. Halberstadt AL, Koedood L, Powell SB, Geyer MA. PMID: 21148021; PMCID: PMC3531560.
      View in: PubMed   Mentions: 64     Fields:    Translation:Animals
    43. CRF2 null mutation increases sensitivity to isolation rearing effects on locomotor activity in mice. Neuropeptides. 2010 Aug; 44(4):349-53. Gresack J, Powell S, Geyer M, Poore MS, Coste S, Risbrough V. PMID: 20466421; PMCID: PMC2888500.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    44. The mouse attentional-set-shifting task: a method for assaying successful cognitive aging? Cogn Affect Behav Neurosci. 2010 May; 10(2):243-51. Young JW, Powell SB, Geyer MA, Jeste DV, Risbrough VB. PMID: 20498348; PMCID: PMC2877277.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    45. Isolation rearing-induced deficits in contextual fear learning do not require CRF(2) receptors. Behav Brain Res. 2010 May 01; 209(1):80-4. Gresack JE, Risbrough VB, Scott CN, Coste S, Stenzel-Poore M, Geyer MA, Powell SB. PMID: 20097235; PMCID: PMC2832092.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    46. Models of neurodevelopmental abnormalities in schizophrenia. Curr Top Behav Neurosci. 2010; 4:435-81. Powell SB. PMID: 21312409; PMCID: PMC3595002.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    47. Neonatal infection with neurotropic influenza A virus induces the kynurenine pathway in early life and disrupts sensorimotor gating in adult Tap1-/- mice. Int J Neuropsychopharmacol. 2010 May; 13(4):475-85. Asp L, Holtze M, Powell SB, Karlsson H, Erhardt S. PMID: 19607757; PMCID: PMC2857580.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    48. A Kappa Opioid Model of Atypical Altered Consciousness and Psychosis: U50488, DOI, AC90179 Effects on Prepulse Inhibition and Locomotion in Mice. J Young Investig. 2009 Jul 01; 19(13):1-7. Ruderman MA, Powell SB, Geyer MA. PMID: 25346645; PMCID: PMC4208663.
      View in: PubMed   Mentions: 1  
    49. Prepulse inhibition and genetic mouse models of schizophrenia. Behav Brain Res. 2009 Dec 07; 204(2):282-94. Powell SB, Zhou X, Geyer MA. PMID: 19397931; PMCID: PMC2735602.
      View in: PubMed   Mentions: 97     Fields:    Translation:Animals
    50. 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology. 2009 Jul; 34(8):1958-67. Halberstadt AL, van der Heijden I, Ruderman MA, Risbrough VB, Gingrich JA, Geyer MA, Powell SB. PMID: 19322172; PMCID: PMC2697271.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    51. Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia. Pharmacol Ther. 2009 May; 122(2):150-202. Young JW, Powell SB, Risbrough V, Marston HM, Geyer MA. PMID: 19269307; PMCID: PMC2688712.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimals
    52. Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice. Behav Pharmacol. 2008 Sep; 19(5-6):562-5. Powell SB, Young JW, Ong JC, Caron MG, Geyer MA. PMID: 18690110; PMCID: PMC2693185.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    53. Contributions of dopamine D1, D2, and D3 receptor subtypes to the disruptive effects of cocaine on prepulse inhibition in mice. Neuropsychopharmacology. 2008 Oct; 33(11):2648-56. Doherty JM, Masten VL, Powell SB, Ralph RJ, Klamer D, Low MJ, Geyer MA. PMID: 18075489.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    54. Overview of animal models of schizophrenia. Curr Protoc Neurosci. 2007 Apr; Chapter 9:Unit 9.24. Powell SB, Geyer MA. PMID: 18428667.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    55. Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats. Neuropharmacology. 2006 Sep; 51(3):457-65. Barr AM, Powell SB, Markou A, Geyer MA. PMID: 16762376.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    56. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May; 317(2):910-8. Vanover KE, Weiner DM, Makhay M, Veinbergs I, Gardell LR, Lameh J, Del Tredici AL, Piu F, Schiffer HH, Ott TR, Burstein ES, Uldam AK, Thygesen MB, Schlienger N, Andersson CM, Son TY, Harvey SC, Powell SB, Geyer MA, Tolf BR, Brann MR, Davis RE. PMID: 16469866.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    57. Isolation rearing of mice induces deficits in prepulse inhibition of the startle response. Behav Brain Res. 2006 Apr 25; 169(1):162-7. Varty GB, Powell SB, Lehmann-Masten V, Buell MR, Geyer MA. PMID: 16406103.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    58. Yohimbine disrupts prepulse inhibition in rats via action at 5-HT1A receptors, not alpha2-adrenoceptors. Psychopharmacology (Berl). 2005 Jul; 180(3):491-500. Powell SB, Palomo J, Carasso BS, Bakshi VP, Geyer MA. PMID: 15719216.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    59. Reduced N-acetylaspartate in the temporal cortex of rats reared in isolation. Biol Psychiatry. 2004 Aug 15; 56(4):296-9. Harte MK, Powell SB, Reynolds LM, Swerdlow NR, Geyer MA, Reynolds GP. PMID: 15312819.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    60. The balance between approach and avoidance behaviors in a novel object exploration paradigm in mice. Behav Brain Res. 2004 Jul 09; 152(2):341-9. Powell SB, Geyer MA, Gallagher D, Paulus MP. PMID: 15196802.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    61. MDMA "ecstasy" alters hyperactive and perseverative behaviors in dopamine transporter knockout mice. Psychopharmacology (Berl). 2004 May; 173(3-4):310-7. Powell SB, Lehmann-Masten VD, Paulus MP, Gainetdinov RR, Caron MG, Geyer MA. PMID: 14747902.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    62. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar; 44(4):473-81. Powell SB, Paulus MP, Hartman DS, Godel T, Geyer MA. PMID: 12646284.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    63. Dopamine depletion of the nucleus accumbens reverses isolation-induced deficits in prepulse inhibition in rats. Neuroscience. 2003; 119(1):233-40. Powell SB, Geyer MA, Preece MA, Pitcher LK, Reynolds GP, Swerdlow NR. PMID: 12763084.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    64. Isolation rearing-induced deficits in prepulse inhibition and locomotor habituation are not potentiated by water deprivation. Physiol Behav. 2002 Sep; 77(1):55-64. Powell SB, Swerdlow NR, Pitcher LK, Geyer MA. PMID: 12213502.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    65. Developmental markers of psychiatric disorders as identified by sensorimotor gating. Neurotox Res. 2002 Aug-Sep; 4(5-6):489-502. Powell SB, Geyer MA. PMID: 12754162.
      View in: PubMed   Mentions: 19     Fields:    
    66. Dissociation between spontaneously emitted and apomorphine-induced stereotypy in Peromyscus maniculatus bairdii. Physiol Behav. 2002 Mar; 75(3):347-53. Presti MF, Powell SB, Lewis MH. PMID: 11897261.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
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