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    Steven Wagner

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0624
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      A Dominantly Inherited AD network In Vitro Trial with a Gamma-Secretase Modulator
      VA I01RX002259Jun 1, 2017 - May 31, 2021
      Role: Principal Investigator
      Optimization and preclinical development of soluble gamma-secretase modulators for AD
      NIH/NIA U01AG048986May 15, 2016 - Apr 30, 2019
      Role: Principal Investigator
      Translational Center for Alzheimer's Disease Target and Drug Discovery
      NIH/NIA R34AG049646Sep 30, 2014 - Aug 31, 2015
      Role: Principal Investigator
      Polytherapy for AD: Combining Gamma-secretase Modulation and CRFR1 Antagonism
      NIH/NIA R21AG047484Sep 1, 2014 - Apr 30, 2016
      Role: Principal Investigator
      Optimization of Soluble Gamma-secretase Modulators for the Treatment of Alzheimer
      NIH/NINDS U01NS074501Jul 1, 2011 - Jun 30, 2016
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner S, Tanzi RE, Zhang C. Soluble Gamma-secretase Modulators Attenuate Alzheimer's ß-amyloid Pathology and Induce Conformational Changes in Presenilin 1. EBioMedicine. 2017 Sep 04. PMID: 28919280.
        View in: PubMed
      2. Wagner S, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. Pharmacological and Toxicological Properties of the Potent Oral ?-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 Jul; 362(1):31-44. PMID: 28416568.
        View in: PubMed
      3. Rynearson KD, Buckle RN, Barnes KD, Herr RJ, Mayhew NJ, Paquette WD, Sakwa SA, Nguyen PD, Johnson G, Tanzi RE, Wagner S. Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme. Bioorg Med Chem Lett. 2016 Aug 15; 26(16):3928-37. PMID: 27426299.
        View in: PubMed
      4. Das U, Wang L, Ganguly A, Saikia JM, Wagner S, Koo EH, Roy S. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan; 19(1):55-64. PMID: 26642089; PMCID: PMC4782935.
      5. D'Avanzo C, Sliwinski C, Wagner S, Tanzi RE, Kim DY, Kovacs DM. ?-Secretase modulators reduce endogenous amyloid ß42 levels in human neural progenitor cells without altering neuronal differentiation. FASEB J. 2015 Aug; 29(8):3335-41. PMID: 25903103; PMCID: PMC4511200.
      6. Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner S, Mobley WC, Wu C. A ?-secretase inhibitor, but not a ?-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379. PMID: 25710492; PMCID: PMC4339551.
      7. Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, Wu X, Li Y, Wagner S, Wang R, Koide S, Sisodia SS. A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of ?-secretase. J Biol Chem. 2014 Dec 12; 289(50):34851-61. PMID: 25352592; PMCID: PMC4263884.
      8. Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner S, Tanzi RE, Kim DY. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 2014 Nov 13; 515(7526):274-8. PMID: 25307057; PMCID: PMC4366007.
      9. Wagner S, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species. Biochemistry. 2014 Feb 04; 53(4):702-13. PMID: 24401146; PMCID: PMC3929337.
      10. Zeiger W, Vetrivel KS, Buggia-Prévot V, Nguyen PD, Wagner S, Villereal ML, Thinakaran G. Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease ß-amyloid peptide secretion. J Biol Chem. 2013 Sep 13; 288(37):26955-66. PMID: 23902769; PMCID: PMC3772244.
      11. Wagner S, Tanzi RE, Mobley WC, Galasko D. Potential use of ?-secretase modulators in the treatment of Alzheimer disease. Arch Neurol. 2012 Oct; 69(10):1255-8. PMID: 22801784; PMCID: PMC3747667.
      12. Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner S, Prabhakar R, Thinakaran G. Loss of cleavage at ß'-site contributes to apparent increase in ß-amyloid peptide (Aß) secretion by ß-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein. J Biol Chem. 2011 Jul 22; 286(29):26166-77. PMID: 21642424; PMCID: PMC3138254.
      13. Lessard CB, Wagner S, Koo EH. And four equals one: presenilin takes the gamma-secretase role by itself. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21236-7. PMID: 21135249; PMCID: PMC3003118.
      14. Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner S, Parent AT, Thinakaran G. Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates. J Biol Chem. 2010 Dec 03; 285(49):38042-52. PMID: 20921220; PMCID: PMC2992238.
      15. Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner S. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010 Sep 09; 67(5):769-80. PMID: 20826309; PMCID: PMC2947312.
      16. Varvel NH, Bhaskar K, Kounnas MZ, Wagner S, Yang Y, Lamb BT, Herrup K. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest. 2009 Dec; 119(12):3692-702. PMID: 19907078; PMCID: PMC2786797.
      17. Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner S, Moir RD, Becker KD, Tanzi RE. Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum Mol Genet. 2009 Oct 15; 18(20):3987-96. PMID: 19608551; PMCID: PMC2748890.
      18. Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner S, Blacker D, Becker KD, Tanzi RE. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet. 2008 Nov; 83(5):623-32. PMID: 18976728; PMCID: PMC2668052.
      19. Bertram L, Mullin K, Parkinson M, Hsiao M, Moscarillo TJ, Wagner S, Becker KD, Velicelebi G, Blacker D, Tanzi RE. Is alpha-T catenin (VR22) an Alzheimer's disease risk gene? J Med Genet. 2007 Jan; 44(1):e63. PMID: 17209133; PMCID: PMC2597918.
      20. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner S, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006 Oct 27; 281(43):32240-53. PMID: 16945923.
        View in: PubMed
      21. Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner S, Becker KD, Blacker D, Tanzi RE. Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med. 2005 Mar 03; 352(9):884-94. PMID: 15745979.
        View in: PubMed
      22. Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner S. Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897. Biochem Pharmacol. 2005 Feb 15; 69(4):689-98. PMID: 15670587.
        View in: PubMed
      23. Song ES, Juliano MA, Juliano L, Fried MG, Wagner S, Hersh LB. ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety. J Biol Chem. 2004 Dec 24; 279(52):54216-20. PMID: 15494400.
        View in: PubMed
      24. Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner S, Younkin SG, Borchelt DR. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet. 2004 Jan 15; 13(2):159-70. PMID: 14645205.
        View in: PubMed
      25. Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, Laird NM, Wang X, Velicelebi G, Wagner S, Becker DK, Tanzi RE, Blacker D. Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet. 2003 Nov 01; 12(21):2765-76. PMID: 12966032.
        View in: PubMed