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    Steven Dowdy

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentCellular and Molecular Medicine
    Address9500 Gilman Drive #0686
    CA La Jolla 92093
    Phone858-534-7772
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      Collapse Overview 
      Collapse Overview
      Our lab is interested in the regulation of G1 cell cycle progression in cancer and determining the consequences of these genetic and epigenetic alterations and the mechanisms that activate the cell cycle machinery.

      Research Focus Areas



      Collapse Research 
      Collapse Research Activities and Funding
      Treating Adenovirus Conjunctivitis with Next-Gen siRNN RNAi Prodrugs
      NIH/NEI R21EY027507Mar 1, 2017 - Feb 28, 2019
      Role: Principal Investigator
      Treating Prostate Cancer with RNAi Prodrugs
      NIH/NCI R21CA195191Sep 1, 2015 - Aug 31, 2017
      Role: Principal Investigator
      Novel Cell Cycle Therapeutic Targets in Pancreatic Cancer
      NIH/NCI R21CA169849Mar 1, 2013 - Feb 28, 2015
      Role: Principal Investigator
      Transduction of Tumor Suppressor Proteins into Gliomas
      NIH/NCI R01CA096098Sep 5, 2001 - Jul 31, 2006
      Role: Principal Investigator
      Comprehensive Biology: Exploiting the Yeast Genome
      NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
      Role: Co-Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Matsuda S, Hammaker D, Topolewski K, Briegel KJ, Boyle DL, Dowdy S, Wang W, Firestein GS. Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene. J Immunol. 2017 Aug 14. PMID: 28807995.
        View in: PubMed
      2. Yoshioka N, Dowdy S. Enhanced generation of iPSCs from older adult human cells by a synthetic five-factor self-replicative RNA. PLoS One. 2017; 12(7):e0182018. PMID: 28750082.
        View in: PubMed
      3. Kolosenko I, Edsbäcker E, Björklund AC, Hamil AS, Goroshchuk O, Grandér D, Dowdy S, Palm-Apergi C. RNAi prodrugs targeting Plk1 induce specific gene silencing in primary cells from pediatric T-acute lymphoblastic leukemia patients. J Control Release. 2017 Sep 10; 261:199-206. PMID: 28684168.
        View in: PubMed
      4. Dowdy S. Overcoming cellular barriers for RNA therapeutics. Nat Biotechnol. 2017 Mar; 35(3):222-229. PMID: 28244992.
        View in: PubMed
      5. Lönn P, Kacsinta AD, Cui XS, Hamil AS, Kaulich M, Gogoi K, Dowdy S. Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics. Sci Rep. 2016; 6:32301. PMID: 27604151.
        View in: PubMed
      6. Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy S, Desai A, Shiau AK, Oegema K. 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. J Cell Biol. 2016 Jul 18; 214(2):155-66. PMID: 27432897.
        View in: PubMed
      7. Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy S, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim DH, Kim JS, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla ME, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T. Voices of biotech. Nat Biotechnol. 2016 Mar 10; 34(3):270-5. PMID: 26963549.
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      8. Hamil AS, Dowdy S. Synthesis and Conjugation of Small Interfering Ribonucleic Neutral SiRNNs. Methods Mol Biol. 2016; 1364:1-9. PMID: 26472437.
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      9. Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy S, King CC, Newton AC. Protein kinase C? exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. Biochem J. 2016 Feb 15; 473(4):509-23. PMID: 26635352.
        View in: PubMed
      10. Kacsinta AD, Dowdy S. Current views on inducing synthetic lethal RNAi responses in the treatment of cancer. Expert Opin Biol Ther. 2016 Feb; 16(2):161-72. PMID: 26630128.
        View in: PubMed
      11. Kaulich M, Dowdy S. Combining CRISPR/Cas9 and rAAV Templates for Efficient Gene Editing. Nucleic Acid Ther. 2015 Dec; 25(6):287-96. PMID: 26540648.
        View in: PubMed
      12. Lönn P, Dowdy S. Cationic PTD/CPP-mediated macromolecular delivery: charging into the cell. Expert Opin Drug Deliv. 2015 Oct; 12(10):1627-36. PMID: 25994800.
        View in: PubMed
      13. Shin D, Lönn P, Dowdy S, Tor Y. Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates. Chem Commun (Camb). 2015 Jan 15; 51(9):1662-5. PMID: 25500944.
        View in: PubMed
      14. Kaulich M, Lee YJ, Lönn P, Springer AD, Meade BR, Dowdy S. Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi. Nucleic Acids Res. 2015 Apr 20; 43(7):e45. PMID: 25586224.
        View in: PubMed
      15. Meade BR, Gogoi K, Hamil AS, Palm-Apergi C, Berg Av, Hagopian JC, Springer AD, Eguchi A, Kacsinta AD, Dowdy CF, Presente A, Lönn P, Kaulich M, Yoshioka N, Gros E, Cui XS, Dowdy S. Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications. Nat Biotechnol. 2014 Dec; 32(12):1256-61. PMID: 25402614.
        View in: PubMed
      16. Lönn P, Dowdy S. 14. From bench to bedside: cationic TAT peptide transduction domain enters cells by macropinocytosis (2005): Original research article: Cationic TAT peptide transduction domain enters cells by macropinocytosis, 2005. J Control Release. 2014 Sep 28; 190:56-8. PMID: 25356487.
        View in: PubMed
      17. Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy S, Reya T, Karin M. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13870-5. PMID: 25189770.
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      18. Narasimha AM, Kaulich M, Shapiro GS, Choi YJ, Sicinski P, Dowdy S. Cyclin D activates the Rb tumor suppressor by mono-phosphorylation. Elife. 2014; 3. PMID: 24876129.
        View in: PubMed
      19. Yoshioka N, Gros E, Li HR, Kumar S, Deacon DC, Maron C, Muotri AR, Chi NC, Fu XD, Yu BD, Dowdy S. Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013 Aug 1; 13(2):246-54. PMID: 23910086.
        View in: PubMed
      20. Kogiso T, Nagahara H, Otsuka M, Shiratori K, Dowdy S. Transdifferentiation of human fibroblasts into hepatocyte-like cells by defined transcriptional factors. Hepatol Int. 2013 Jul; 7(3):937-44. PMID: 26201932.
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      21. Presente A, Dowdy S. PTD/CPP peptide-mediated delivery of siRNAs. Curr Pharm Des. 2013; 19(16):2943-7. PMID: 23140460.
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      22. Wadia J, Eguchi A, Dowdy S. DNA delivery into mammalian cells using bacteriophage ? displaying the TAT transduction domain. Cold Spring Harb Protoc. 2013 Jan; 2013(1). PMID: 23282641.
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      23. Keerthivasan G, Liu H, Gump JM, Dowdy S, Wickrema A, Crispino JD. A novel role for survivin in erythroblast enucleation. Haematologica. 2012 Oct; 97(10):1471-9. PMID: 22491741.
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      24. Palm-Apergi C, Lönn P, Dowdy S. Do cell-penetrating peptides actually "penetrate" cellular membranes? Mol Ther. 2012 Apr; 20(4):695-7. PMID: 22472979.
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      25. van den Berg A, Dowdy S. Protein transduction domain delivery of therapeutic macromolecules. Curr Opin Biotechnol. 2011 Dec; 22(6):888-93. PMID: 21489777.
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      26. Palm-Apergi C, Eguchi A, Dowdy S. PTD-DRBD siRNA delivery. Methods Mol Biol. 2011; 683:339-47. PMID: 21053141.
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      27. June RK, Gogoi K, Eguchi A, Cui XS, Dowdy S. Synthesis of a pH-sensitive nitrilotriacetic linker to peptide transduction domains to enable intracellular delivery of histidine imidazole ring-containing macromolecules. J Am Chem Soc. 2010 Aug 11; 132(31):10680-2. PMID: 20681698.
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      28. Pawar SA, Sarkar TR, Balamurugan K, Sharan S, Wang J, Zhang Y, Dowdy S, Huang AM, Sterneck E. C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9210-5. PMID: 20439707.
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      29. Eguchi A, Dowdy S. Efficient siRNA delivery by novel PTD-DRBD fusion proteins. Cell Cycle. 2010 Feb 1; 9(3):424-5. PMID: 20090414.
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      30. Michiue H, Eguchi A, Scadeng M, Dowdy S. Induction of in vivo synthetic lethal RNAi responses to treat glioblastoma. Cancer Biol Ther. 2009 Dec; 8(23):2306-13. PMID: 19901546.
        View in: PubMed
      31. Meade BR, Dowdy S. The road to therapeutic RNA interference (RNAi): Tackling the 800 pound siRNA delivery gorilla. Discov Med. 2009 Dec; 8(43):253-6. PMID: 20040280.
        View in: PubMed
      32. Gump JM, June RK, Dowdy S. Revised role of glycosaminoglycans in TAT protein transduction domain-mediated cellular transduction. J Biol Chem. 2010 Jan 8; 285(2):1500-7. PMID: 19858185.
        View in: PubMed
      33. Eguchi A, Dowdy S. siRNA delivery using peptide transduction domains. Trends Pharmacol Sci. 2009 Jul; 30(7):341-5. PMID: 19545914.
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      34. Eguchi A, Meade BR, Chang YC, Fredrickson CT, Willert K, Puri N, Dowdy S. Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein. Nat Biotechnol. 2009 Jun; 27(6):567-71. PMID: 19448630.
        View in: PubMed
      35. Wagner MV, Smolka MB, de Bruin RA, Zhou H, Wittenberg C, Dowdy S. Whi5 regulation by site specific CDK-phosphorylation in Saccharomyces cerevisiae. PLoS One. 2009; 4(1):e4300. PMID: 19172996.
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      36. Cerchietti LC, Yang SN, Shaknovich R, Hatzi K, Polo JM, Chadburn A, Dowdy S, Melnick A. A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo. Blood. 2009 Apr 9; 113(15):3397-405. PMID: 18927431.
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      37. Wadia JS, Schaller M, Williamson RA, Dowdy S. Pathologic prion protein infects cells by lipid-raft dependent macropinocytosis. PLoS One. 2008; 3(10):e3314. PMID: 19390657.
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      38. Xu Y, Liu S, Yu G, Chen J, Chen J, Xu X, Wu Y, Zhang A, Dowdy S, Cheng G. Excision of selectable genes from transgenic goat cells by a protein transducible TAT-Cre recombinase. Gene. 2008 Aug 1; 419(1-2):70-4. PMID: 18547746.
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      39. Cerchietti LC, Polo JM, Da Silva GF, Farinha P, Shaknovich R, Gascoyne RD, Dowdy S, Melnick A. Sequential transcription factor targeting for diffuse large B-cell lymphomas. Cancer Res. 2008 May 1; 68(9):3361-9. PMID: 18451163.
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      40. Besson A, Dowdy S, Roberts JM. CDK inhibitors: cell cycle regulators and beyond. Dev Cell. 2008 Feb; 14(2):159-69. PMID: 18267085.
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      41. Meade BR, Dowdy S. Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides. Adv Drug Deliv Rev. 2008 Mar 1; 60(4-5):530-6. PMID: 18155315.
        View in: PubMed
      42. Denicourt C, Saenz CC, Datnow B, Cui XS, Dowdy S. Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma. Cancer Res. 2007 Oct 1; 67(19):9238-43. PMID: 17909030.
        View in: PubMed
      43. Gump JM, Dowdy S. TAT transduction: the molecular mechanism and therapeutic prospects. Trends Mol Med. 2007 Oct; 13(10):443-8. PMID: 17913584.
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      44. Meade BR, Dowdy S. Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides. Adv Drug Deliv Rev. 2007 Mar 30; 59(2-3):134-40. PMID: 17451840.
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      45. Muntean AG, Pang L, Poncz M, Dowdy S, Blobel GA, Crispino JD. Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization. Blood. 2007 Jun 15; 109(12):5199-207. PMID: 17317855.
        View in: PubMed
      46. Haberichter T, Mädge B, Christopher RA, Yoshioka N, Dhiman A, Miller R, Gendelman R, Aksenov SV, Khalil IG, Dowdy S. A systems biology dynamical model of mammalian G1 cell cycle progression. Mol Syst Biol. 2007; 3:84. PMID: 17299420.
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      47. Dowdy S. The anonymous American Idol manuscript reviewer. Cell. 2006 Nov 17; 127(4):662-3; author reply 664-5. PMID: 17110321.
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      48. Murriel CL, Dowdy S. Influence of protein transduction domains on intracellular delivery of macromolecules. Expert Opin Drug Deliv. 2006 Nov; 3(6):739-46. PMID: 17076596.
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      49. Havens CG, Ho A, Yoshioka N, Dowdy S. Regulation of late G1/S phase transition and APC Cdh1 by reactive oxygen species. Mol Cell Biol. 2006 Jun; 26(12):4701-11. PMID: 16738333.
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      50. Cai SR, Xu G, Becker-Hapak M, Ma M, Dowdy S, McLeod HL. The kinetics and tissue distribution of protein transduction in mice. Eur J Pharm Sci. 2006 Mar; 27(4):311-9. PMID: 16376528.
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      51. Snyder EL, Saenz CC, Denicourt C, Meade BR, Cui XS, Kaplan IM, Dowdy S. Enhanced targeting and killing of tumor cells expressing the CXC chemokine receptor 4 by transducible anticancer peptides. Cancer Res. 2005 Dec 1; 65(23):10646-50. PMID: 16322205.
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      52. Kaplan IM, Wadia JS, Dowdy S. Cationic TAT peptide transduction domain enters cells by macropinocytosis. J Control Release. 2005 Jan 20; 102(1):247-53. PMID: 15653149.
        View in: PubMed
      53. Snyder EL, Dowdy S. Recent advances in the use of protein transduction domains for the delivery of peptides, proteins and nucleic acids in vivo. Expert Opin Drug Deliv. 2005 Jan; 2(1):43-51. PMID: 16296734.
        View in: PubMed
      54. Wadia JS, Dowdy S. Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer. Adv Drug Deliv Rev. 2005 Feb 28; 57(4):579-96. PMID: 15722165.
        View in: PubMed
      55. Denicourt C, Dowdy S. Medicine. Targeting apoptotic pathways in cancer cells. Science. 2004 Sep 3; 305(5689):1411-3. PMID: 15353788.
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      56. Wadia JS, Wagner MV, Ezhevsky SA, Dowdy S. Apoptin/VP3 contains a concentration-dependent nuclear localization signal (NLS), not a tumorigenic selective NLS. J Virol. 2004 Jun; 78(11):6077-8. PMID: 15141008.
        View in: PubMed
      57. Denicourt C, Dowdy S. Cip/Kip proteins: more than just CDKs inhibitors. Genes Dev. 2004 Apr 15; 18(8):851-5. PMID: 15107401.
        View in: PubMed
      58. Snyder EL, Dowdy S. Cell penetrating peptides in drug delivery. Pharm Res. 2004 Mar; 21(3):389-93. PMID: 15070086.
        View in: PubMed
      59. Snyder EL, Meade BR, Saenz CC, Dowdy S. Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide. PLoS Biol. 2004 Feb; 2(2):E36. PMID: 14966535.
        View in: PubMed
      60. Wadia JS, Stan RV, Dowdy S. Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat Med. 2004 Mar; 10(3):310-5. PMID: 14770178.
        View in: PubMed
      61. Katterle Y, Brandt BH, Dowdy S, Niggemann B, Zänker KS, Dittmar T. Antitumour effects of PLC-gamma1-(SH2)2-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells. Br J Cancer. 2004 Jan 12; 90(1):230-5. PMID: 14710234.
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      62. Denicourt C, Dowdy S. Another twist in the transforming growth factor beta-induced cell-cycle arrest chronicle. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15290-1. PMID: 14676328.
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      63. Yu BD, Becker-Hapak M, Snyder EL, Vooijs M, Denicourt C, Dowdy S. Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival. Proc Natl Acad Sci U S A. 2003 Dec 9; 100(25):14881-6. PMID: 14630948.
        View in: PubMed
      64. Snyder EL, Meade BR, Dowdy S. Anti-cancer protein transduction strategies: reconstitution of p27 tumor suppressor function. J Control Release. 2003 Aug 28; 91(1-2):45-51. PMID: 12932636.
        View in: PubMed
      65. Denicourt C, Dowdy S. Protein transduction technology offers novel therapeutic approach for brain ischemia. Trends Pharmacol Sci. 2003 May; 24(5):216-8. PMID: 12767717.
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      66. Becker-Hapak M, Dowdy S. Protein transduction: generation of full-length transducible proteins using the TAT system. Curr Protoc Cell Biol. 2003 May; Chapter 20:Unit 20.2. PMID: 18228426.
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      67. Wadia JS, Dowdy S. Modulation of cellular function by TAT mediated transduction of full length proteins. Curr Protein Pept Sci. 2003 Apr; 4(2):97-104. PMID: 12678849.
        View in: PubMed
      68. Tanaka Y, Dowdy S, Linehan DC, Eberlein TJ, Goedegebuure PS. Induction of antigen-specific CTL by recombinant HIV trans-activating fusion protein-pulsed human monocyte-derived dendritic cells. J Immunol. 2003 Feb 1; 170(3):1291-8. PMID: 12538688.
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      69. McAllister SS, Becker-Hapak M, Pintucci G, Pagano M, Dowdy S. Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol Cell Biol. 2003 Jan; 23(1):216-28. PMID: 12482975.
        View in: PubMed
      70. Hsia CY, Cheng S, Owyang AM, Dowdy S, Liou HC. c-Rel regulation of the cell cycle in primary mouse B lymphocytes. Int Immunol. 2002 Aug; 14(8):905-16. PMID: 12147627.
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      71. Ho A, Dowdy S. Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes. Curr Opin Genet Dev. 2002 Feb; 12(1):47-52. PMID: 11790554.
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      72. Wadia JS, Dowdy S. Protein transduction technology. Curr Opin Biotechnol. 2002 Feb; 13(1):52-6. PMID: 11849958.
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      73. Davis PK, Dowdy S. p73. Int J Biochem Cell Biol. 2001 Oct; 33(10):935-9. PMID: 11470228.
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      74. Soga N, Namba N, McAllister S, Cornelius L, Teitelbaum SL, Dowdy S, Kawamura J, Hruska KA. Rho family GTPases regulate VEGF-stimulated endothelial cell motility. Exp Cell Res. 2001 Sep 10; 269(1):73-87. PMID: 11525641.
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      75. Klekotka PA, Santoro SA, Ho A, Dowdy S, Zutter MM. Mammary epithelial cell-cycle progression via the alpha(2)beta(1) integrin: unique and synergistic roles of the alpha(2) cytoplasmic domain. Am J Pathol. 2001 Sep; 159(3):983-92. PMID: 11549591.
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      76. Becker-Hapak M, McAllister SS, Dowdy S. TAT-mediated protein transduction into mammalian cells. Methods. 2001 Jul; 24(3):247-56. PMID: 11403574.
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      77. Ezhevsky SA, Ho A, Becker-Hapak M, Davis PK, Dowdy S. Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo. Mol Cell Biol. 2001 Jul; 21(14):4773-84. PMID: 11416152.
        View in: PubMed
      78. Abu-Amer Y, Dowdy S, Ross FP, Clohisy JC, Teitelbaum SL. TAT fusion proteins containing tyrosine 42-deleted IkappaBalpha arrest osteoclastogenesis. J Biol Chem. 2001 Aug 10; 276(32):30499-503. PMID: 11408488.
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      79. Davis PK, Ho A, Dowdy S. Biological methods for cell-cycle synchronization of mammalian cells. Biotechniques. 2001 Jun; 30(6):1322-6, 1328, 1330-1. PMID: 11414226.
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      80. Snyder EL, Dowdy S. Protein/peptide transduction domains: potential to deliver large DNA molecules into cells. Curr Opin Mol Ther. 2001 Apr; 3(2):147-52. PMID: 11338927.
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      81. Ho A, Schwarze SR, Mermelstein SJ, Waksman G, Dowdy S. Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo. Cancer Res. 2001 Jan 15; 61(2):474-7. PMID: 11212234.
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      82. Zezula J, Casaccia-Bonnefil P, Ezhevsky SA, Osterhout DJ, Levine JM, Dowdy S, Chao MV, Koff A. p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal. EMBO Rep. 2001 Jan; 2(1):27-34. PMID: 11252720.
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      83. Vocero-Akbani A, Chellaiah MA, Hruska KA, Dowdy S. Protein transduction: delivery of Tat-GTPase fusion proteins into mammalian cells. Methods Enzymol. 2001; 332:36-49. PMID: 11305111.
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      84. Lissy NA, Davis PK, Irwin M, Kaelin WG, Dowdy S. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature. 2000 Oct 5; 407(6804):642-5. PMID: 11034214.
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      85. Schwarze SR, Hruska KA, Dowdy S. Protein transduction: unrestricted delivery into all cells? Trends Cell Biol. 2000 Jul; 10(7):290-5. PMID: 10856932.
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      86. Chellaiah MA, Soga N, Swanson S, McAllister S, Alvarez U, Wang D, Dowdy S, Hruska KA. Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. J Biol Chem. 2000 Apr 21; 275(16):11993-2002. PMID: 10766830.
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      87. Schwarze SR, Dowdy S. In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA. Trends Pharmacol Sci. 2000 Feb; 21(2):45-8. PMID: 10664605.
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      88. Vocero-Akbani A, Lissy NA, Dowdy S. Transduction of full-length Tat fusion proteins directly into mammalian cells: analysis of T cell receptor activation-induced cell death. Methods Enzymol. 2000; 322:508-21. PMID: 10914043.
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      89. Nagahara H, Ezhevsky SA, Vocero-Akbani AM, Kaldis P, Solomon MJ, Dowdy S. Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14961-6. PMID: 10611320.
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      90. Schwarze SR, Ho A, Vocero-Akbani A, Dowdy S. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science. 1999 Sep 3; 285(5433):1569-72. PMID: 10477521.
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      91. Gius DR, Ezhevsky SA, Becker-Hapak M, Nagahara H, Wei MC, Dowdy S. Transduced p16INK4a peptides inhibit hypophosphorylation of the retinoblastoma protein and cell cycle progression prior to activation of Cdk2 complexes in late G1. Cancer Res. 1999 Jun 1; 59(11):2577-80. PMID: 10363976.
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      92. Vocero-Akbani AM, Heyden NV, Lissy NA, Ratner L, Dowdy S. Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein. Nat Med. 1999 Jan; 5(1):29-33. PMID: 9883836.
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      93. Nagahara H, Latek RR, Ezhevsky SA, Dowdy S. 2-D phosphopeptide mapping. Methods Mol Biol. 1999; 112:271-9. PMID: 10027251.
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      94. Nagahara H, Vocero-Akbani AM, Snyder EL, Ho A, Latham DG, Lissy NA, Becker-Hapak M, Ezhevsky SA, Dowdy S. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med. 1998 Dec; 4(12):1449-52. PMID: 9846587.
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      95. Grakoui A, VanDyk LF, Dowdy S, Allen PM. Molecular basis for the lack of T cell proliferation induced by an altered peptide ligand. Int Immunol. 1998 Jul; 10(7):969-79. PMID: 9701035.
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      96. Lissy NA, Van Dyk LF, Becker-Hapak M, Vocero-Akbani A, Mendler JH, Dowdy S. TCR antigen-induced cell death occurs from a late G1 phase cell cycle check point. Immunity. 1998 Jan; 8(1):57-65. PMID: 9462511.
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      97. Ezhevsky SA, Nagahara H, Vocero-Akbani AM, Gius DR, Wei MC, Dowdy S. Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10699-704. PMID: 9380698.
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      98. Neuman E, Ladha MH, Lin N, Upton TM, Miller SJ, DiRenzo J, Pestell RG, Hinds PW, Dowdy S, Brown M, Ewen ME. Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4. Mol Cell Biol. 1997 Sep; 17(9):5338-47. PMID: 9271411.
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      99. Reid LH, West A, Gioeli DG, Phillips KK, Kelleher KF, Araujo D, Stanbridge EJ, Dowdy S, Gerhard DS, Weissman BE. Localization of a tumor suppressor gene in 11p15.5 using the G401 Wilms' tumor assay. Hum Mol Genet. 1996 Feb; 5(2):239-47. PMID: 8824880.
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