Steven Dowdy

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-3083-2257 Additional info
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    Collapse Biography 
    Collapse Education and Training
    UC IrvinePhD1990Molecular Genetics
    Whitehead Institute at MITPostdoc1994Tumor Suppressor Genes

    Collapse Overview 
    Collapse Overview
    Our lab's early research was focused on understanding the molecular basis of G1 cell cycle deregulation during oncogenesis by the RB and p16 tumor suppressor genes, and cyclin:dk complexes. Our later work has focused on the synthetic chemistry, development and delivery of novel siRNA and ASO therapeutics to treat human disease. Our current work is focused on addressing the rate-limiting delivery step of all RNA therapeutics by synthesis of biomimetic endosomal escape molecules.

    Collapse Research 
    Collapse Research Activities and Funding
    Development of Next-Generation Precision Medicine RNAi Therapeutics to Treat AML
    NIH R21CA252511Jul 1, 2020 - Jun 30, 2022
    Role: Principal Investigator
    Development of Next-Generation RNAi Therapeutics to Treat Alzheimer's Disease
    NIH R21NS116663Apr 1, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Development of Antibody-RNAi Conjugates (ARCs) to Treat Lung Cancer
    NIH R21CA234740Dec 19, 2018 - Nov 30, 2020
    Role: Principal Investigator
    Treating Adenovirus Conjunctivitis with Next-Gen siRNN RNAi Prodrugs
    NIH R21EY027507Mar 1, 2017 - Feb 29, 2020
    Role: Principal Investigator
    Treating Prostate Cancer with RNAi Prodrugs
    NIH R21CA195191Sep 1, 2015 - Aug 31, 2017
    Role: Principal Investigator
    Novel Cell Cycle Therapeutic Targets in Pancreatic Cancer
    NIH R21CA169849Mar 1, 2013 - Feb 28, 2015
    Role: Principal Investigator
    Transduction of Tumor Suppressor Proteins into Gliomas
    NIH R01CA096098Sep 5, 2001 - Jul 31, 2006
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    Regulation of RNA metabolism and cell growth control by SR protein kinases
    NIH R01GM052872May 1, 1996 - Oct 31, 2020
    Role: Principal Investigator

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Design, Synthesis, and Biochemical Analysis of a Molecule Designed to Enhance Endosomal Escape. AAPS J. 2023 Dec 22; 26(1):10. Jadhav SG, Setten RL, Medina C, Cui XS, Dowdy SF. PMID: 38133698.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product. Expert Opin Drug Deliv. 2023 Jul-Dec; 20(9):1157-1166. Dowdy SF, Gallagher CJ, Vitarella D, Brown J. PMID: 37847051.
      View in: PubMed   Mentions:    Fields:    
    3. Reply to: Ptbp1 deletion does not induce astrocyte-to-neuron conversion. Nature. 2023 Jun; 618(7964):E8-E13. Hao Y, Hu J, Xue Y, Dowdy SF, Mobley WC, Qian H, Fu XD. PMID: 37286647.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    4. Endosomal escape of RNA therapeutics: How do we solve this rate-limiting problem? RNA. 2023 04; 29(4):396-401. Dowdy SF. PMID: 36669888; PMCID: PMC10019367.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    5. DNA/RNA heteroduplex oligonucleotides: An unanticipated twist in the delivery of ASOs. Mol Ther Nucleic Acids. 2022 Sep 13; 29:133-134. Setten RL, Dowdy SF. PMID: 35847172; PMCID: PMC9256975.
      View in: PubMed   Mentions: 1  
    6. Delivery of RNA Therapeutics: The Great Endosomal Escape! Nucleic Acid Ther. 2022 10; 32(5):361-368. Dowdy SF, Setten RL, Cui XS, Jadhav SG. PMID: 35612432; PMCID: PMC9595607.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    7. Protein Delivery by PTDs/CPPs. Methods Mol Biol. 2022; 2383:257-264. Palm-Apergi C, Dowdy SF. PMID: 34766295.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transition. Sci Rep. 2021 07 19; 11(1):14736. Kaulich M, Link VM, Lapek JD, Lee YJ, Glass CK, Gonzalez DJ, Dowdy SF. PMID: 34282211; PMCID: PMC8290049.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. RNAi prodrugs decrease elevated mRNA levels of Polo-like kinase 1 in ex vivo cultured primary cells from pediatric acute myeloid leukemia patients. FASEB J. 2021 05; 35(5):e21476. Kolosenko I, Goroshchuk O, Vidarsdottir L, Björklund AC, Dowdy SF, Palm-Apergi C. PMID: 33788972.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Overcoming delivery barriers with LNPs. Nat Mater. 2021 05; 20(5):575-577. Jadhav SG, Dowdy SF. PMID: 33911220.
      View in: PubMed   Mentions: 5     Fields:    
    11. The TAT Protein Transduction Domain as an Intra-Articular Drug Delivery Technology. Cartilage. 2021 12; 13(2_suppl):1637S-1645S. Mailhiot SE, Thompson MA, Eguchi AE, Dinkel SE, Lotz MK, Dowdy SF, June RK. PMID: 32954793; PMCID: PMC8804766.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 Aug; 584(7820):E17. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32724206.
      View in: PubMed   Mentions: 2     Fields:    
    13. Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 06; 582(7813):550-556. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32581380; PMCID: PMC7521455.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansAnimalsCells
    14. Targeting Plk1 with siRNNs in primary cells from pediatric B-cell acute lymphoblastic leukemia patients. Sci Rep. 2020 02 14; 10(1):2688. Goroshchuk O, Vidarsdottir L, Björklund AC, Hamil AS, Kolosenko I, Dowdy SF, Palm-Apergi C. PMID: 32060361; PMCID: PMC7021816.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. Two-pore channels regulate Tat endolysosome escape and Tat-mediated HIV-1 LTR transactivation. FASEB J. 2020 03; 34(3):4147-4162. Khan N, Halcrow PW, Lakpa KL, Afghah Z, Miller NM, Dowdy SF, Geiger JD, Chen X. PMID: 31950548; PMCID: PMC7079041.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    16. Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase. Molecules. 2019 Sep 10; 24(18). Huggins IJ, Medina CA, Springer AD, van den Berg A, Jadhav S, Cui X, Dowdy SF. PMID: 31509944; PMCID: PMC6767100.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    17. Controlling CRISPR-Cas9 Gene Editing. N Engl J Med. 2019 Jul 18; 381(3):289-290. Dowdy SF. PMID: 31314976.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics. Nucleic Acid Ther. 2018 06; 28(3):109-118. Springer AD, Dowdy SF. PMID: 29792572; PMCID: PMC5994659.
      View in: PubMed   Mentions: 188     Fields:    Translation:Cells
    19. RNA Therapeutics (Almost) Comes of Age: Targeting, Delivery and Endosomal Escape. Nucleic Acid Ther. 2018 06; 28(3):107-108. Dowdy SF, Levy M. PMID: 29782220.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. Induction of RNAi Responses by Short Left-Handed Hairpin RNAi Triggers. Nucleic Acid Ther. 2017 Oct; 27(5):260-271. Hagopian JC, Hamil AS, van den Berg A, Meade BR, Eguchi A, Palm-Apergi C, Dowdy SF. PMID: 28933656; PMCID: PMC5649124.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene. J Immunol. 2017 10 01; 199(7):2316-2322. Matsuda S, Hammaker D, Topolewski K, Briegel KJ, Boyle DL, Dowdy S, Wang W, Firestein GS. PMID: 28807995; PMCID: PMC5605444.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    22. Enhanced generation of iPSCs from older adult human cells by a synthetic five-factor self-replicative RNA. PLoS One. 2017; 12(7):e0182018. Yoshioka N, Dowdy SF. PMID: 28750082; PMCID: PMC5531586.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    23. RNAi prodrugs targeting Plk1 induce specific gene silencing in primary cells from pediatric T-acute lymphoblastic leukemia patients. J Control Release. 2017 09 10; 261:199-206. Kolosenko I, Edsbäcker E, Björklund AC, Hamil AS, Goroshchuk O, Grandér D, Dowdy SF, Palm-Apergi C. PMID: 28684168.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. Overcoming cellular barriers for RNA therapeutics. Nat Biotechnol. 2017 Mar; 35(3):222-229. Dowdy SF. PMID: 28244992.
      View in: PubMed   Mentions: 349     Fields:    Translation:HumansAnimalsCells
    25. Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics. Sci Rep. 2016 09 08; 6:32301. Lönn P, Kacsinta AD, Cui XS, Hamil AS, Kaulich M, Gogoi K, Dowdy SF. PMID: 27604151; PMCID: PMC5015074.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansCells
    26. 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. J Cell Biol. 2016 07 18; 214(2):155-66. Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K. PMID: 27432897; PMCID: PMC4949453.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    27. Voices of biotech. Nat Biotechnol. 2016 Mar; 34(3):270-5. Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim DH, Kim JS, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla ME, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T. PMID: 26963549.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    28. Synthesis and Conjugation of Small Interfering Ribonucleic Neutral SiRNNs. Methods Mol Biol. 2016; 1364:1-9. Hamil AS, Dowdy SF. PMID: 26472437; PMCID: PMC5568848.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    29. Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. Biochem J. 2016 Feb 15; 473(4):509-23. Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC, Newton AC. PMID: 26635352; PMCID: PMC4888060.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    30. Current views on inducing synthetic lethal RNAi responses in the treatment of cancer. Expert Opin Biol Ther. 2016; 16(2):161-72. Kacsinta AD, Dowdy SF. PMID: 26630128.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    31. Combining CRISPR/Cas9 and rAAV Templates for Efficient Gene Editing. Nucleic Acid Ther. 2015 Dec; 25(6):287-96. Kaulich M, Dowdy SF. PMID: 26540648; PMCID: PMC4657517.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    32. Cationic PTD/CPP-mediated macromolecular delivery: charging into the cell. Expert Opin Drug Deliv. 2015; 12(10):1627-36. Lönn P, Dowdy SF. PMID: 25994800.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    33. Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates. Chem Commun (Camb). 2015 Jan 31; 51(9):1662-5. Shin D, Lönn P, Dowdy SF, Tor Y. PMID: 25500944; PMCID: PMC4298453.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    34. Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi. Nucleic Acids Res. 2015 Apr 20; 43(7):e45. Kaulich M, Lee YJ, Lönn P, Springer AD, Meade BR, Dowdy SF. PMID: 25586224; PMCID: PMC4402508.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    35. Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications. Nat Biotechnol. 2014 Dec; 32(12):1256-61. Meade BR, Gogoi K, Hamil AS, Palm-Apergi C, van den Berg A, Hagopian JC, Springer AD, Eguchi A, Kacsinta AD, Dowdy CF, Presente A, Lönn P, Kaulich M, Yoshioka N, Gros E, Cui XS, Dowdy SF. PMID: 25402614; PMCID: PMC4378643.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimals
    36. 14. From bench to bedside: cationic TAT peptide transduction domain enters cells by macropinocytosis (2005): Original research article: Cationic TAT peptide transduction domain enters cells by macropinocytosis, 2005. J Control Release. 2014 Sep 28; 190:56-8. Lönn P, Dowdy SF. PMID: 25356487.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13870-5. Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M. PMID: 25189770; PMCID: PMC4183333.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    38. Cyclin D activates the Rb tumor suppressor by mono-phosphorylation. Elife. 2014 Jun 04; 3. Narasimha AM, Kaulich M, Shapiro GS, Choi YJ, Sicinski P, Dowdy SF. PMID: 24876129; PMCID: PMC4076869.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansAnimalsCells
    39. Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013 Aug 01; 13(2):246-54. Yoshioka N, Gros E, Li HR, Kumar S, Deacon DC, Maron C, Muotri AR, Chi NC, Fu XD, Yu BD, Dowdy SF. PMID: 23910086; PMCID: PMC3845961.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    40. Transdifferentiation of human fibroblasts into hepatocyte-like cells by defined transcriptional factors. Hepatol Int. 2013 Jul; 7(3):937-44. Kogiso T, Nagahara H, Otsuka M, Shiratori K, Dowdy SF. PMID: 26201932.
      View in: PubMed   Mentions: 12     Fields:    
    41. DNA delivery into mammalian cells using bacteriophage λ displaying the TAT transduction domain. Cold Spring Harb Protoc. 2013 Jan 01; 2013(1). Wadia J, Eguchi A, Dowdy SF. PMID: 23282641.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    42. PTD/CPP peptide-mediated delivery of siRNAs. Curr Pharm Des. 2013; 19(16):2943-7. Presente A, Dowdy SF. PMID: 23140460.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    43. A novel role for survivin in erythroblast enucleation. Haematologica. 2012 Oct; 97(10):1471-9. Keerthivasan G, Liu H, Gump JM, Dowdy SF, Wickrema A, Crispino JD. PMID: 22491741; PMCID: PMC3487547.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    44. Do cell-penetrating peptides actually "penetrate" cellular membranes? Mol Ther. 2012 Apr; 20(4):695-7. Palm-Apergi C, Lönn P, Dowdy SF. PMID: 22472979; PMCID: PMC3322330.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    45. Protein transduction domain delivery of therapeutic macromolecules. Curr Opin Biotechnol. 2011 Dec; 22(6):888-93. van den Berg A, Dowdy SF. PMID: 21489777.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    46. PTD-DRBD siRNA delivery. Methods Mol Biol. 2011; 683:339-47. Palm-Apergi C, Eguchi A, Dowdy SF. PMID: 21053141.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    47. Synthesis of a pH-sensitive nitrilotriacetic linker to peptide transduction domains to enable intracellular delivery of histidine imidazole ring-containing macromolecules. J Am Chem Soc. 2010 Aug 11; 132(31):10680-2. June RK, Gogoi K, Eguchi A, Cui XS, Dowdy SF. PMID: 20681698; PMCID: PMC2915637.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    48. C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9210-5. Pawar SA, Sarkar TR, Balamurugan K, Sharan S, Wang J, Zhang Y, Dowdy SF, Huang AM, Sterneck E. PMID: 20439707; PMCID: PMC2889124.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    49. Efficient siRNA delivery by novel PTD-DRBD fusion proteins. Cell Cycle. 2010 Feb 01; 9(3):424-5. Eguchi A, Dowdy SF. PMID: 20090414.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    50. Induction of in vivo synthetic lethal RNAi responses to treat glioblastoma. Cancer Biol Ther. 2009 Dec; 8(23):2306-13. Michiue H, Eguchi A, Scadeng M, Dowdy SF. PMID: 19901546.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    51. The road to therapeutic RNA interference (RNAi): Tackling the 800 pound siRNA delivery gorilla. Discov Med. 2009 Dec; 8(43):253-6. Meade BR, Dowdy SF. PMID: 20040280.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    52. Revised role of glycosaminoglycans in TAT protein transduction domain-mediated cellular transduction. J Biol Chem. 2010 Jan 08; 285(2):1500-7. Gump JM, June RK, Dowdy SF. PMID: 19858185; PMCID: PMC2801275.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    53. siRNA delivery using peptide transduction domains. Trends Pharmacol Sci. 2009 Jul; 30(7):341-5. Eguchi A, Dowdy SF. PMID: 19545914.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    54. Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein. Nat Biotechnol. 2009 Jun; 27(6):567-71. Eguchi A, Meade BR, Chang YC, Fredrickson CT, Willert K, Puri N, Dowdy SF. PMID: 19448630; PMCID: PMC2694965.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    55. Whi5 regulation by site specific CDK-phosphorylation in Saccharomyces cerevisiae. PLoS One. 2009; 4(1):e4300. Wagner MV, Smolka MB, de Bruin RA, Zhou H, Wittenberg C, Dowdy SF. PMID: 19172996; PMCID: PMC2627923.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    56. A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo. Blood. 2009 Apr 09; 113(15):3397-405. Cerchietti LC, Yang SN, Shaknovich R, Hatzi K, Polo JM, Chadburn A, Dowdy SF, Melnick A. PMID: 18927431; PMCID: PMC2668844.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    57. Pathologic prion protein infects cells by lipid-raft dependent macropinocytosis. PLoS One. 2008; 3(10):e3314. Wadia JS, Schaller M, Williamson RA, Dowdy SF. PMID: 19390657; PMCID: PMC2671965.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    58. Excision of selectable genes from transgenic goat cells by a protein transducible TAT-Cre recombinase. Gene. 2008 Aug 01; 419(1-2):70-4. Xu Y, Liu S, Yu G, Chen J, Chen J, Xu X, Wu Y, Zhang A, Dowdy SF, Cheng G. PMID: 18547746.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    59. Sequential transcription factor targeting for diffuse large B-cell lymphomas. Cancer Res. 2008 May 01; 68(9):3361-9. Cerchietti LC, Polo JM, Da Silva GF, Farinha P, Shaknovich R, Gascoyne RD, Dowdy SF, Melnick A. PMID: 18451163; PMCID: PMC2748725.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    60. CDK inhibitors: cell cycle regulators and beyond. Dev Cell. 2008 Feb; 14(2):159-69. Besson A, Dowdy SF, Roberts JM. PMID: 18267085.
      View in: PubMed   Mentions: 491     Fields:    Translation:HumansAnimalsCells
    61. Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides. Adv Drug Deliv Rev. 2008 Mar 01; 60(4-5):530-6. Meade BR, Dowdy SF. PMID: 18155315; PMCID: PMC2293332.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    62. Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma. Cancer Res. 2007 Oct 01; 67(19):9238-43. Denicourt C, Saenz CC, Datnow B, Cui XS, Dowdy SF. PMID: 17909030.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    63. TAT transduction: the molecular mechanism and therapeutic prospects. Trends Mol Med. 2007 Oct; 13(10):443-8. Gump JM, Dowdy SF. PMID: 17913584.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimals
    64. Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides. Adv Drug Deliv Rev. 2007 Mar 30; 59(2-3):134-40. Meade BR, Dowdy SF. PMID: 17451840.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    65. Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization. Blood. 2007 Jun 15; 109(12):5199-207. Muntean AG, Pang L, Poncz M, Dowdy SF, Blobel GA, Crispino JD. PMID: 17317855; PMCID: PMC1890844.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    66. A systems biology dynamical model of mammalian G1 cell cycle progression. Mol Syst Biol. 2007; 3:84. Haberichter T, Mädge B, Christopher RA, Yoshioka N, Dhiman A, Miller R, Gendelman R, Aksenov SV, Khalil IG, Dowdy SF. PMID: 17299420; PMCID: PMC1828753.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    67. The anonymous American Idol manuscript reviewer. Cell. 2006 Nov 17; 127(4):662-3; author reply 664-5. Dowdy SF. PMID: 17110321.
      View in: PubMed   Mentions: 1     Fields:    
    68. Influence of protein transduction domains on intracellular delivery of macromolecules. Expert Opin Drug Deliv. 2006 Nov; 3(6):739-46. Murriel CL, Dowdy SF. PMID: 17076596.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    69. Regulation of late G1/S phase transition and APC Cdh1 by reactive oxygen species. Mol Cell Biol. 2006 Jun; 26(12):4701-11. Havens CG, Ho A, Yoshioka N, Dowdy SF. PMID: 16738333; PMCID: PMC1489138.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    70. The kinetics and tissue distribution of protein transduction in mice. Eur J Pharm Sci. 2006 Mar; 27(4):311-9. Cai SR, Xu G, Becker-Hapak M, Ma M, Dowdy SF, McLeod HL. PMID: 16376528.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    71. Enhanced targeting and killing of tumor cells expressing the CXC chemokine receptor 4 by transducible anticancer peptides. Cancer Res. 2005 Dec 01; 65(23):10646-50. Snyder EL, Saenz CC, Denicourt C, Meade BR, Cui XS, Kaplan IM, Dowdy SF. PMID: 16322205.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    72. Cationic TAT peptide transduction domain enters cells by macropinocytosis. J Control Release. 2005 Jan 20; 102(1):247-53. Kaplan IM, Wadia JS, Dowdy SF. PMID: 15653149.
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    73. Recent advances in the use of protein transduction domains for the delivery of peptides, proteins and nucleic acids in vivo. Expert Opin Drug Deliv. 2005 Jan; 2(1):43-51. Snyder EL, Dowdy SF. PMID: 16296734.
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    74. Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer. Adv Drug Deliv Rev. 2005 Feb 28; 57(4):579-96. Wadia JS, Dowdy SF. PMID: 15722165.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    75. Medicine. Targeting apoptotic pathways in cancer cells. Science. 2004 Sep 03; 305(5689):1411-3. Denicourt C, Dowdy SF. PMID: 15353788.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    76. Apoptin/VP3 contains a concentration-dependent nuclear localization signal (NLS), not a tumorigenic selective NLS. J Virol. 2004 Jun; 78(11):6077-8. Wadia JS, Wagner MV, Ezhevsky SA, Dowdy SF. PMID: 15141008; PMCID: PMC415785.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    77. Cip/Kip proteins: more than just CDKs inhibitors. Genes Dev. 2004 Apr 15; 18(8):851-5. Denicourt C, Dowdy SF. PMID: 15107401.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimals
    78. Cell penetrating peptides in drug delivery. Pharm Res. 2004 Mar; 21(3):389-93. Snyder EL, Dowdy SF. PMID: 15070086.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    79. Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide. PLoS Biol. 2004 Feb; 2(2):E36. Snyder EL, Meade BR, Saenz CC, Dowdy SF. PMID: 14966535; PMCID: PMC340944.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    80. Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat Med. 2004 Mar; 10(3):310-5. Wadia JS, Stan RV, Dowdy SF. PMID: 14770178.
      View in: PubMed   Mentions: 473     Fields:    Translation:HumansAnimalsCells
    81. Antitumour effects of PLC-gamma1-(SH2)2-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells. Br J Cancer. 2004 Jan 12; 90(1):230-5. Katterle Y, Brandt BH, Dowdy SF, Niggemann B, Zänker KS, Dittmar T. PMID: 14710234; PMCID: PMC2395298.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    82. Another twist in the transforming growth factor beta-induced cell-cycle arrest chronicle. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15290-1. Denicourt C, Dowdy SF. PMID: 14676328; PMCID: PMC307558.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    83. Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):14881-6. Yu BD, Becker-Hapak M, Snyder EL, Vooijs M, Denicourt C, Dowdy SF. PMID: 14630948; PMCID: PMC299840.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    84. Anti-cancer protein transduction strategies: reconstitution of p27 tumor suppressor function. J Control Release. 2003 Aug 28; 91(1-2):45-51. Snyder EL, Meade BR, Dowdy SF. PMID: 12932636.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    85. Protein transduction technology offers novel therapeutic approach for brain ischemia. Trends Pharmacol Sci. 2003 May; 24(5):216-8. Denicourt C, Dowdy SF. PMID: 12767717.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    86. Protein transduction: generation of full-length transducible proteins using the TAT system. Curr Protoc Cell Biol. 2003 May; Chapter 20:Unit 20.2. Becker-Hapak M, Dowdy SF. PMID: 18228426.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    87. Modulation of cellular function by TAT mediated transduction of full length proteins. Curr Protein Pept Sci. 2003 Apr; 4(2):97-104. Wadia JS, Dowdy SF. PMID: 12678849.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    88. Induction of antigen-specific CTL by recombinant HIV trans-activating fusion protein-pulsed human monocyte-derived dendritic cells. J Immunol. 2003 Feb 01; 170(3):1291-8. Tanaka Y, Dowdy SF, Linehan DC, Eberlein TJ, Goedegebuure PS. PMID: 12538688.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    89. Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol Cell Biol. 2003 Jan; 23(1):216-28. McAllister SS, Becker-Hapak M, Pintucci G, Pagano M, Dowdy SF. PMID: 12482975; PMCID: PMC140659.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    90. c-Rel regulation of the cell cycle in primary mouse B lymphocytes. Int Immunol. 2002 Aug; 14(8):905-16. Hsia CY, Cheng S, Owyang AM, Dowdy SF, Liou HC. PMID: 12147627.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    91. Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes. Curr Opin Genet Dev. 2002 Feb; 12(1):47-52. Ho A, Dowdy SF. PMID: 11790554.
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    92. p73. Int J Biochem Cell Biol. 2001 Oct; 33(10):935-9. Davis PK, Dowdy SF. PMID: 11470228.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    93. Mammary epithelial cell-cycle progression via the alpha(2)beta(1) integrin: unique and synergistic roles of the alpha(2) cytoplasmic domain. Am J Pathol. 2001 Sep; 159(3):983-92. Klekotka PA, Santoro SA, Ho A, Dowdy SF, Zutter MM. PMID: 11549591; PMCID: PMC1850465.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    94. Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo. Mol Cell Biol. 2001 Jul; 21(14):4773-84. Ezhevsky SA, Ho A, Becker-Hapak M, Davis PK, Dowdy SF. PMID: 11416152; PMCID: PMC87164.
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    95. Biological methods for cell-cycle synchronization of mammalian cells. Biotechniques. 2001 Jun; 30(6):1322-6, 1328, 1330-1. Davis PK, Ho A, Dowdy SF. PMID: 11414226.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    96. Protein/peptide transduction domains: potential to deliver large DNA molecules into cells. Curr Opin Mol Ther. 2001 Apr; 3(2):147-52. Snyder EL, Dowdy SF. PMID: 11338927.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    97. p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal. EMBO Rep. 2001 Jan; 2(1):27-34. Zezula J, Casaccia-Bonnefil P, Ezhevsky SA, Osterhout DJ, Levine JM, Dowdy SF, Chao MV, Koff A. PMID: 11252720; PMCID: PMC1083805.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    98. Protein transduction: delivery of Tat-GTPase fusion proteins into mammalian cells. Methods Enzymol. 2001; 332:36-49. Vocero-Akbani A, Chellaiah MA, Hruska KA, Dowdy SF. PMID: 11305111.
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    99. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature. 2000 Oct 05; 407(6804):642-5. Lissy NA, Davis PK, Irwin M, Kaelin WG, Dowdy SF. PMID: 11034214.
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    100. Protein transduction: unrestricted delivery into all cells? Trends Cell Biol. 2000 Jul; 10(7):290-5. Schwarze SR, Hruska KA, Dowdy SF. PMID: 10856932.
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    101. Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. J Biol Chem. 2000 Apr 21; 275(16):11993-2002. Chellaiah MA, Soga N, Swanson S, McAllister S, Alvarez U, Wang D, Dowdy SF, Hruska KA. PMID: 10766830.
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    102. In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA. Trends Pharmacol Sci. 2000 Feb; 21(2):45-8. Schwarze SR, Dowdy SF. PMID: 10664605.
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    103. Transduction of full-length Tat fusion proteins directly into mammalian cells: analysis of T cell receptor activation-induced cell death. Methods Enzymol. 2000; 322:508-21. Vocero-Akbani A, Lissy NA, Dowdy SF. PMID: 10914043.
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    104. Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14961-6. Nagahara H, Ezhevsky SA, Vocero-Akbani AM, Kaldis P, Solomon MJ, Dowdy SF. PMID: 10611320; PMCID: PMC24755.
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    105. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science. 1999 Sep 03; 285(5433):1569-72. Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF. PMID: 10477521.
      View in: PubMed   Mentions: 719     Fields:    Translation:HumansAnimalsCells
    106. Transduced p16INK4a peptides inhibit hypophosphorylation of the retinoblastoma protein and cell cycle progression prior to activation of Cdk2 complexes in late G1. Cancer Res. 1999 Jun 01; 59(11):2577-80. Gius DR, Ezhevsky SA, Becker-Hapak M, Nagahara H, Wei MC, Dowdy SF. PMID: 10363976.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    107. 2-D phosphopeptide mapping. Methods Mol Biol. 1999; 112:271-9. Nagahara H, Latek RR, Ezhevsky SA, Dowdy SF. PMID: 10027251.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    108. Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein. Nat Med. 1999 Jan; 5(1):29-33. Vocero-Akbani AM, Heyden NV, Lissy NA, Ratner L, Dowdy SF. PMID: 9883836.
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    109. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med. 1998 Dec; 4(12):1449-52. Nagahara H, Vocero-Akbani AM, Snyder EL, Ho A, Latham DG, Lissy NA, Becker-Hapak M, Ezhevsky SA, Dowdy SF. PMID: 9846587.
      View in: PubMed   Mentions: 267     Fields:    Translation:HumansCells
    110. Molecular basis for the lack of T cell proliferation induced by an altered peptide ligand. Int Immunol. 1998 Jul; 10(7):969-79. Grakoui A, VanDyk LF, Dowdy SF, Allen PM. PMID: 9701035.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    111. TCR antigen-induced cell death occurs from a late G1 phase cell cycle check point. Immunity. 1998 Jan; 8(1):57-65. Lissy NA, Van Dyk LF, Becker-Hapak M, Vocero-Akbani A, Mendler JH, Dowdy SF. PMID: 9462511.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    112. Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10699-704. Ezhevsky SA, Nagahara H, Vocero-Akbani AM, Gius DR, Wei MC, Dowdy SF. PMID: 9380698; PMCID: PMC23451.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    113. Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4. Mol Cell Biol. 1997 Sep; 17(9):5338-47. Neuman E, Ladha MH, Lin N, Upton TM, Miller SJ, DiRenzo J, Pestell RG, Hinds PW, Dowdy SF, Brown M, Ewen ME. PMID: 9271411; PMCID: PMC232384.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    114. Localization of a tumor suppressor gene in 11p15.5 using the G401 Wilms' tumor assay. Hum Mol Genet. 1996 Feb; 5(2):239-47. Reid LH, West A, Gioeli DG, Phillips KK, Kelleher KF, Araujo D, Stanbridge EJ, Dowdy SF, Gerhard DS, Weissman BE. PMID: 8824880.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    115. Function of a human cyclin gene as an oncogene. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):709-13. Hinds PW, Dowdy SF, Eaton EN, Arnold A, Weinberg RA. PMID: 8290586; PMCID: PMC43018.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    116. The cancer cell and the cell cycle clock. Cold Spring Harb Symp Quant Biol. 1994; 59:1-10. Hatakeyama M, Herrera RA, Makela T, Dowdy SF, Jacks T, Weinberg RA. PMID: 7587058.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    117. Physical interaction of the retinoblastoma protein with human D cyclins. Cell. 1993 May 07; 73(3):499-511. Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA. PMID: 8490963.
      View in: PubMed   Mentions: 228     Fields:    Translation:HumansCells
    118. Expression, purification, and functional characterization of adenovirus 5 and 12 E1A proteins produced in insect cells. Virology. 1992 Oct; 190(2):733-45. Peeper DS, Zantema A, Dowdy SF, van der Eb AJ. PMID: 1387752.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    119. The retinoblastoma protein and the regulation of cell cycling. Trends Biochem Sci. 1992 Aug; 17(8):312-5. Cobrinik D, Dowdy SF, Hinds PW, Mittnacht S, Weinberg RA. PMID: 1412705.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    120. The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells. Nucleic Acids Res. 1991 Oct 25; 19(20):5763-9. Dowdy SF, Lai KM, Weissman BE, Matsui Y, Hogan BL, Stanbridge EJ. PMID: 1658743; PMCID: PMC328988.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    121. Suppression of tumorigenicity in Wilms tumor by the p15.5-p14 region of chromosome 11. Science. 1991 Oct 11; 254(5029):293-5. Dowdy SF, Fasching CL, Araujo D, Lai KM, Livanos E, Weissman BE, Stanbridge EJ. PMID: 1656527.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    122. Correlation of the inability to sustain growth in defined serum-free medium with the suppression of tumorigenicity in Wilms' nephroblastoma. J Cell Physiol. 1991 May; 147(2):248-55. Dowdy SF, Weissman BE, Stanbridge EJ. PMID: 1645741.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    123. Modulation of retinoblastoma protein activity during the cell cycle. Cold Spring Harb Symp Quant Biol. 1991; 56:197-209. Mittnacht S, Hinds PW, Dowdy SF, Weinberg RA. PMID: 1819486.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
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