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    Soumita Das

    TitleAssistant Professor
    SchoolUniversity of California, San Diego
    DepartmentPathology
    Address 9500 Gilman Drive BRFII Room 4A21
    CA La Jolla 92093
    Phone858-246-2062
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      Collapse Research 
      Collapse Research Activities and Funding
      Innate responses following infection with enteric microbes
      NIH R01DK107585Sep 1, 2016 - Aug 31, 2021
      Role: Principal Investigator
      Engulfment of enteric bacteria and the consequences for intestinal inflammation
      NIH R56DK099275Sep 1, 2014 - Aug 31, 2015
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hwang JH, Lyes M, Sladewski K, Enany S, McEachern E, Mathew DP, Das S, Moshensky A, Bapat S, Pride DT, Ongkeko WM, Crotty Alexander LE. Electronic cigarette inhalation alters innate immunity and airway cytokines while increasing the virulence of colonizing bacteria. J Mol Med (Berl). 2016 Jun; 94(6):667-79. PMID: 26804311.
        View in: PubMed
      2. den Hartog G, Chattopadhyay R, Ablack A, Hall EH, Butcher LD, Bhattacharyya A, Eckmann L, Harris PR, Das S, Ernst PB, Crowe SE. Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia. PLoS Pathog. 2016 Jan; 12(1):e1005382. PMID: 26761793; PMCID: PMC4711900.
      3. Fox S, Ryan KA, Berger AH, Petro K, Das S, Crowe SE, Ernst PB. The role of C1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during Helicobacter pylori infection. J Inflamm (Lond). 2015; 12:51. PMID: 26357509; PMCID: PMC4563842.
      4. Das S, Sarkar A, Choudhury SS, Owen KA, Castillo V, Fox S, Eckmann L, Elliott MR, Casanova JE, Ernst PB. ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. Cell Mol Gastroenterol Hepatol. 2015 Apr 01; 1(3):311-324. PMID: 26878033.
        View in: PubMed
      5. Das S, Sarkar A, Ryan KA, Fox S, Berger AH, Juncadella IJ, Bimczok D, Smythies LE, Harris PR, Ravichandran KS, Crowe SE, Smith PD, Ernst PB. Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells. FASEB J. 2014 May; 28(5):2214-24. PMID: 24509909; PMCID: PMC3986834.
      6. Bimczok D, Smythies LE, Waites KB, Grams JM, Stahl RD, Mannon PJ, Peter S, Wilcox CM, Harris PR, Das S, Ernst PB, Smith PD. Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells. J Immunol. 2013 Jun 15; 190(12):6626-34. PMID: 23686492; PMCID: PMC3725581.
      7. Mauldin JP, Lu M, Das S, Park D, Ernst PB, Ravichandran KS. A link between the cytoplasmic engulfment protein Elmo1 and the Mediator complex subunit Med31. Curr Biol. 2013 Jan 21; 23(2):162-7. PMID: 23273896; PMCID: PMC3556191.
      8. Park D, Han CZ, Elliott MR, Kinchen JM, Trampont PC, Das S, Collins S, Lysiak JJ, Hoehn KL, Ravichandran KS. Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein. Nature. 2011 Aug 21; 477(7363):220-4. PMID: 21857682; PMCID: PMC3513690.
      9. Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, Sifri CD, Ravichandran KS, Ernst PB, Casanova JE. Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):2136-41. PMID: 21245295; PMCID: PMC3033312.
      10. Alam MS, Kurtz CC, Rowlett RM, Reuter BK, Wiznerowicz E, Das S, Linden J, Crowe SE, Ernst PB. CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice. J Infect Dis. 2009 Feb 15; 199(4):494-504. PMID: 19281303; PMCID: PMC3047419.
      11. Chattopadhyay R, Das S, Maiti AK, Boldogh I, Xie J, Hazra TK, Kohno K, Mitra S, Bhakat KK. Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. Mol Cell Biol. 2008 Dec; 28(23):7066-80. PMID: 18809583; PMCID: PMC2593380.
      12. Das S, Chattopadhyay R, Bhakat KK, Boldogh I, Kohno K, Prasad R, Wilson SH, Hazra TK. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. J Biol Chem. 2007 Sep 28; 282(39):28474-84. PMID: 17686777; PMCID: PMC2679419.
      13. Beswick EJ, Pinchuk IV, Das S, Powell DW, Reyes VE. Expression of the programmed death ligand 1, B7-H1, on gastric epithelial cells after Helicobacter pylori exposure promotes development of CD4+ CD25+ FoxP3+ regulatory T cells. Infect Immun. 2007 Sep; 75(9):4334-41. PMID: 17562772; PMCID: PMC1951191.
      14. Das S, Suarez G, Beswick EJ, Sierra JC, Graham DY, Reyes VE. Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection. J Immunol. 2006 Mar 01; 176(5):3000-9. PMID: 16493058.
        View in: PubMed
      15. Beswick EJ, Das S, Pinchuk IV, Adegboyega P, Suarez G, Yamaoka Y, Reyes VE. Helicobacter pylori-induced IL-8 production by gastric epithelial cells up-regulates CD74 expression. J Immunol. 2005 Jul 01; 175(1):171-6. PMID: 15972644.
        View in: PubMed
      16. Sarkar M, Das S, Bandyopadhaya A, Ray K, Chaudhuri K. Upregulation of human mitochondrial NADH dehydrogenase subunit 5 in intestinal epithelial cells is modulated by Vibrio cholerae pathogenesis. FEBS Lett. 2005 Jun 20; 579(16):3449-60. PMID: 15946665.
        View in: PubMed
      17. Das S, Sierra JC, Soman KV, Suarez G, Mohammad AA, Dang TA, Luxon BA, Reyes VE. Differential protein expression profiles of gastric epithelial cells following Helicobacter pylori infection using ProteinChips. J Proteome Res. 2005 May-Jun; 4(3):920-30. PMID: 15952739.
        View in: PubMed
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