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    Sotirios Tsimikas

    TitleProfessor Of Clinical
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0682
    CA La Jolla 92093
    Phone858-534-6109
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      Collapse Research 
      Collapse Research Activities and Funding
      Oxidation-specific nanoparticles for imaging atherosclerosis
      NIH/NHLBI R01HL119828Aug 21, 2013 - Jul 31, 2018
      Role: Principal Investigator
      IMAGING ATHEROSCLEROSIS WITH SPECIFIC ANTIBODIES
      NIH/NHLBI K08HL003793Dec 15, 1997 - Nov 30, 2002
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hartikainen J, Hassinen I, Hedman A, Kivelä A, Saraste A, Knuuti J, Husso M, Mussalo H, Hedman M, Rissanen TT, Toivanen P, Heikura T, Witztum JL, Tsimikas S, Ylä-Herttuala S. Adenoviral intramyocardial VEGF-D?N?C gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up. Eur Heart J. 2017 Sep 01; 38(33):2547-2555. PMID: 28903476.
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      2. Kamstrup PR, Hung MY, Witztum JL, Tsimikas S, Nordestgaard BG. Oxidized Phospholipids and Risk of Calcific Aortic Valve Disease: The Copenhagen General Population Study. Arterioscler Thromb Vasc Biol. 2017 Aug; 37(8):1570-1578. PMID: 28572160.
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      3. van Capelleveen JC, Bernelot Moens SJ, Yang X, Kastelein JJP, Wareham NJ, Zwinderman AH, Stroes ESG, Witztum JL, Hovingh GK, Khaw KT, Boekholdt SM, Tsimikas S. Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study. Arterioscler Thromb Vasc Biol. 2017 Jun; 37(6):1206-1212. PMID: 28473441.
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      4. Prasad A, Clopton P, Ayers C, Khera A, de Lemos JA, Witztum JL, Tsimikas S. Relationship of Autoantibodies to MDA-LDL and ApoB-Immune Complexes to Sex, Ethnicity, Subclinical Atherosclerosis, and Cardiovascular Events. Arterioscler Thromb Vasc Biol. 2017 Jun; 37(6):1213-1221. PMID: 28473443.
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      5. Saleheen D, Haycock PC, Zhao W, Rasheed A, Taleb A, Imran A, Abbas S, Majeed F, Akhtar S, Qamar N, Zaman KS, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Mallick NH, Ishaq M, Rasheed SZ, Memon FU, Mahmood K, Ahmed N, Frossard P, Tsimikas S, Witztum JL, Marcovina S, Sandhu M, Rader DJ, Danesh J. Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. Lancet Diabetes Endocrinol. 2017 Jul; 5(7):524-533. PMID: 28408323.
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      6. Yeang C, Gordts PL, Tsimikas S. Novel Lipoprotein(a) Catabolism Pathway via Apolipoprotein(a) Recycling: Adding the Plasminogen Receptor PlgRKT to the List. Circ Res. 2017 Mar 31; 120(7):1050-1052. PMID: 28360338.
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      7. Verbeek R, Sandhu MS, Hovingh GK, Sjouke B, Wareham NJ, Zwinderman AH, Kastelein JJ, Khaw KT, Tsimikas S, Boekholdt SM. Lipoprotein(a) Improves Cardiovascular Risk Prediction Based on Established Risk Algorithms. J Am Coll Cardiol. 2017 Mar 21; 69(11):1513-1515. PMID: 28302296.
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      8. Paige E, Masconi KL, Tsimikas S, Kronenberg F, Santer P, Weger S, Willeit J, Kiechl S, Willeit P. Lipoprotein(a) and incident type-2 diabetes: results from the prospective Bruneck study and a meta-analysis of published literature. Cardiovasc Diabetol. 2017 Mar 21; 16(1):38. PMID: 28320383.
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      9. Capoulade R, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. Autoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial. Atherosclerosis. 2017 May; 260:1-7. PMID: 28319871.
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      10. Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P, Oberhollenzer F, Egger G, Witztum JL, Alexander VJ, Willeit J, Kiechl S, Mayr M. Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III. J Am Coll Cardiol. 2017 Feb 21; 69(7):789-800. PMID: 28209220.
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      11. Lu J, Guo S, Xue X, Chen Q, Ge J, Zhuo Y, Zhong H, Chen B, Zhao M, Han W, Suzuki T, Zhu M, Xia L, Schneider C, Blackwell TS, Porter NA, Zheng L, Tsimikas S, Yin H. Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moiety in vitro and in vivo: Implication in atherosclerosis. J Biol Chem. 2017 Mar 31; 292(13):5378-5391. PMID: 28202546.
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      12. Tsimikas S. A Test in Context: Lipoprotein(a): Diagnosis, Prognosis, Controversies, and Emerging Therapies. J Am Coll Cardiol. 2017 Feb 14; 69(6):692-711. PMID: 28183512.
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      13. Byun YS, Yang X, Bao W, DeMicco D, Laskey R, Witztum JL, Tsimikas S. Oxidized Phospholipids on Apolipoprotein B-100 and Recurrent Ischemic Events Following Stroke or Transient Ischemic Attack. J Am Coll Cardiol. 2017 Jan 17; 69(2):147-158. PMID: 28081824.
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      14. Moriarty PM, Varvel SA, Gordts PL, McConnell JP, Tsimikas S. Lipoprotein(a) Mass Levels Increase Significantly According to APOE Genotype: An Analysis of 431?239 Patients. Arterioscler Thromb Vasc Biol. 2017 Jan 05. PMID: 28062489.
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      15. Wilkinson MJ, Ma GS, Yeang C, Ang L, Strachan M, DeMaria AN, Tsimikas S, Cotter B. The Prevalence of Lipoprotein(a) Measurement and Degree of Elevation Among 2710 Patients With Calcific Aortic Valve Stenosis in an Academic Echocardiography Laboratory Setting. Angiology. 2017 Jan 01; 3319716688415. PMID: 28068801.
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      16. Lee SR, Prasad A, Choi YS, Xing C, Clopton P, Witztum JL, Tsimikas S. The LPA Gene, Ethnicity, and Cardiovascular Events. Circulation. 2016 Nov 9. PMID: 27831500.
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      17. Yeang C, Clopton PC, Tsimikas S. Lipoprotein(a)-cholesterol levels estimated by vertical auto profile correlate poorly with Lp(a) mass in hyperlipidemic subjects: Implications for clinical practice interpretation of Lp(a)-mediated risk. J Clin Lipidol. 2016 Nov - Dec; 10(6):1389-1396. PMID: 27919356.
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      18. Varvel S, McConnell JP, Tsimikas S. Prevalence of Elevated Lp(a) Mass Levels and Patient Thresholds in 532 359 Patients in the United States. Arterioscler Thromb Vasc Biol. 2016 Nov; 36(11):2239-2245. PMID: 27659098.
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      19. Viney NJ, van Capelleveen JC, Geary RS, Xia S, Tami JA, Yu RZ, Marcovina SM, Hughes SG, Graham MJ, Crooke RM, Crooke ST, Witztum JL, Stroes ES, Tsimikas S. Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials. Lancet. 2016 Nov 5; 388(10057):2239-2253. PMID: 27665230.
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      20. van der Valk FM, Bekkering S, Kroon J, Yeang C, Van den Bossche J, van Buul JD, Ravandi A, Nederveen AJ, Verberne HJ, Scipione C, Nieuwdorp M, Joosten LA, Netea MG, Koschinsky ML, Witztum JL, Tsimikas S, Riksen NP, Stroes ES. Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans. Circulation. 2016 Aug 23; 134(8):611-24. PMID: 27496857.
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      21. Tsimikas S. The re-emergence of lipoprotein(a) in a broader clinical arena. Prog Cardiovasc Dis. 2016 Sep - Oct; 59(2):135-144. PMID: 27497506.
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      22. Alexandrou AT, Tsimikas S. Elevated Lp(a) and Abdominal Aortic Aneurysm. Angiology. 2017 Feb; 68(2):96-98. PMID: 27207842.
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      23. DeFilippis AP, Chernyavskiy I, Amraotkar AR, Trainor PJ, Kothari S, Ismail I, Hargis CW, Korley FK, Leibundgut G, Tsimikas S, Rai SN, Bhatnagar A. Circulating levels of plasminogen and oxidized phospholipids bound to plasminogen distinguish between atherothrombotic and non-atherothrombotic myocardial infarction. J Thromb Thrombolysis. 2016 Jul; 42(1):61-76. PMID: 26510751.
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      24. Yeang C, Wilkinson MJ, Tsimikas S. Lipoprotein(a) and oxidized phospholipids in calcific aortic valve stenosis. Curr Opin Cardiol. 2016 Jul; 31(4):440-50. PMID: 27205885.
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      25. Duell PB, Santos RD, Kirwan BA, Witztum JL, Tsimikas S, Kastelein JJ. Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia. J Clin Lipidol. 2016 Jul-Aug; 10(4):1011-21. PMID: 27578134.
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      26. Leibundgut G, Lee JH, Strauss BH, Segev A, Tsimikas S. Acute and long-term effect of percutaneous coronary intervention on serially-measured oxidative, inflammatory, and coagulation biomarkers in patients with stable angina. J Thromb Thrombolysis. 2016 May; 41(4):569-80. PMID: 26964999.
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      27. Tavori H, Christian D, Minnier J, Plubell D, Shapiro MD, Yeang C, Giunzioni I, Croyal M, Duell PB, Lambert G, Tsimikas S, Fazio S. PCSK9 Association With Lipoprotein(a). Circ Res. 2016 Jun 24; 119(1):29-35. PMID: 27121620.
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      28. Yeang C, Tsimikas S. The role of lipoprotein(a) in progression of renal disease: Causality or reverse causality? J Diabetes Complications. 2016 Jul; 30(5):755-7. PMID: 27118508.
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      29. Tsimikas S. Lipoprotein(a): novel target and emergence of novel therapies to lower cardiovascular disease risk. Curr Opin Endocrinol Diabetes Obes. 2016 Apr; 23(2):157-64. PMID: 26825471.
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      30. Yeang C, Hung MY, Byun YS, Clopton P, Yang X, Witztum JL, Tsimikas S. Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a). J Clin Lipidol. 2016 May-Jun; 10(3):594-603. PMID: 27206947.
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      31. Brown WV, Moriarty PM, Remaley AT, Tsimikas S. JCL Roundtable: Should we treat elevations in Lp(a)? J Clin Lipidol. 2016 Mar-Apr; 10(2):215-24. PMID: 27055952.
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      32. Harmon DB, Srikakulapu P, Kaplan JL, Oldham SN, McSkimming C, Garmey JC, Perry HM, Kirby JL, Prohaska TA, Gonen A, Hallowell P, Schirmer B, Tsimikas S, Taylor AM, Witztum JL, McNamara CA. Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. Arterioscler Thromb Vasc Biol. 2016 Apr; 36(4):682-91. PMID: 26868208.
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      33. Yang X, Lee SR, Choi YS, Alexander VJ, Digenio A, Yang Q, Miller YI, Witztum JL, Tsimikas S. Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results. J Lipid Res. 2016 Apr; 57(4):706-13. PMID: 26848137.
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      34. Yeang C, Cotter B, Tsimikas S. Experimental Animal Models Evaluating the Causal Role of Lipoprotein(a) in Atherosclerosis and Aortic Stenosis. Cardiovasc Drugs Ther. 2016 Feb; 30(1):75-85. PMID: 26780907.
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      35. Verbeek R, Boekholdt SM, Stoekenbroek RM, Hovingh GK, Witztum JL, Wareham NJ, Sandhu MS, Khaw KT, Tsimikas S. Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study. J Lipid Res. 2016 Apr; 57(4):697-705. PMID: 26828068.
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      36. Graham MJ, Viney N, Crooke RM, Tsimikas S. Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans. J Lipid Res. 2016 Mar; 57(3):340-51. PMID: 26538546.
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      37. Scipione CA, Sayegh SE, Romagnuolo R, Tsimikas S, Marcovina SM, Boffa MB, Koschinsky ML. Mechanistic insights into Lp(a)-induced IL-8 expression: a role for oxidized phospholipid modification of apo(a). J Lipid Res. 2015 Dec; 56(12):2273-85. PMID: 26474593.
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      38. Capoulade R, Chan KL, Yeang C, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Mahmut A, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis. J Am Coll Cardiol. 2015 Sep 15; 66(11):1236-46. PMID: 26361154.
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      39. Handa JT, Tagami M, Ebrahimi K, Leibundgut G, Janiak A, Witztum JL, Tsimikas S. Lipoprotein(A) with An Intact Lysine Binding Site Protects the Retina From an Age-Related Macular Degeneration Phenotype in Mice (An American Ophthalmological Society Thesis). Trans Am Ophthalmol Soc. 2015 Sep; 113:T51-T522. PMID: 26538774.
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      40. Reeves RR, Ang L, Bahadorani J, Naghi J, Dominguez A, Palakodeti V, Tsimikas S, Patel MP, Mahmud E. Invasive Cardiologists Are Exposed to Greater Left Sided Cranial Radiation: The BRAIN Study (Brain Radiation Exposure and Attenuation During Invasive Cardiology Procedures). JACC Cardiovasc Interv. 2015 Aug 17; 8(9):1197-206. PMID: 26292583.
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      41. Tsimikas S, Viney NJ, Hughes SG, Singleton W, Graham MJ, Baker BF, Burkey JL, Yang Q, Marcovina SM, Geary RS, Crooke RM, Witztum JL. Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study. Lancet. 2015 Oct 10; 386(10002):1472-83. PMID: 26210642.
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      42. Rosenfeld SM, Perry HM, Gonen A, Prohaska TA, Srikakulapu P, Grewal S, Das D, McSkimming C, Taylor AM, Tsimikas S, Bender TP, Witztum JL, McNamara CA. B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis. Circ Res. 2015 Jul 17; 117(3):e28-39. PMID: 26082558.
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      43. Vallejo-Vaz AJ, Kondapally Seshasai SR, Kurogi K, Michishita I, Nozue T, Sugiyama S, Tsimikas S, Yoshida H, Ray KK. Effect of pitavastatin on glucose, HbA1c and incident diabetes: A meta-analysis of randomized controlled clinical trials in individuals without diabetes. Atherosclerosis. 2015 Aug; 241(2):409-18. PMID: 26074315.
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      44. Yeang C, Witztum JL, Tsimikas S. 'LDL-C'?=?LDL-C?+?Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering. Curr Opin Lipidol. 2015 Jun; 26(3):169-78. PMID: 25943842.
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      45. Yeang C, Tsimikas S. HDL-C, ABCA1-mediated cholesterol efflux, and lipoprotein(a): insights into a potential novel physiologic role of lipoprotein(a). J Lipid Res. 2015 Jul; 56(7):1241-4. PMID: 26014961.
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      46. Rao F, Schork AJ, Maihofer AX, Nievergelt CM, Marcovina SM, Miller ER, Witztum JL, O'Connor DT, Tsimikas S. Heritability of Biomarkers of Oxidized Lipoproteins: Twin Pair Study. Arterioscler Thromb Vasc Biol. 2015 Jul; 35(7):1704-11. PMID: 25953646.
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      47. Schricker AA, Feld GK, Tsimikas S. Retrieval of a detached transseptal sheath tip from a right pulmonary artery branch following catheter ablation. Catheter Cardiovasc Interv. 2015 Nov 15; 86(6):1131-5. PMID: 25913843.
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      48. Byun YS, Lee JH, Arsenault BJ, Yang X, Bao W, DeMicco D, Laskey R, Witztum JL, Tsimikas S. Relationship of Oxidized Phospholipids on Apolipoprotein B-100 to Cardiovascular Outcomes in Patients Treated With Intensive Versus Moderate Atorvastatin Therapy: The TNT Trial. J Am Coll Cardiol. 2015 Apr 7; 65(13):1286-95. PMID: 25835440.
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      49. Prasad A, Lane JR, Tsimikas S, Mahmud E, Khandrika S, Bekker P, Ilapakurti M, Nguyen D, Ravandi A, Israel T. Plasma Levels of Advanced Glycation End Products Are Related to the Clinical Presentation and Angiographic Severity of Symptomatic Lower Extremity Peripheral Arterial Disease. Int J Angiol. 2016 Mar; 25(1):44-53. PMID: 26900311.
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      50. Santos RD, Raal FJ, Catapano AL, Witztum JL, Steinhagen-Thiessen E, Tsimikas S. Mipomersen, an Antisense Oligonucleotide to Apolipoprotein B-100, Reduces Lipoprotein(a) in Various Populations With Hypercholesterolemia: Results of 4 Phase III Trials. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):689-99. PMID: 25614280.
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      51. Tsiantoulas D, Perkmann T, Afonyushkin T, Mangold A, Prohaska TA, Papac-Milicevic N, Millischer V, Bartel C, Hörkkö S, Boulanger CM, Tsimikas S, Fischer MB, Witztum JL, Lang IM, Binder CJ. Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies. J Lipid Res. 2015 Feb; 56(2):440-8. PMID: 25525116.
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      52. Hung MY, Tsimikas S. What is the ultimate test that lowering lipoprotein(a) is beneficial for cardiovascular disease and aortic stenosis? Curr Opin Lipidol. 2014 Dec; 25(6):423-30. PMID: 25340480.
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      53. Willeit P, Raschenberger J, Heydon EE, Tsimikas S, Haun M, Mayr A, Weger S, Witztum JL, Butterworth AS, Willeit J, Kronenberg F, Kiechl S. Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis. PLoS One. 2014; 9(11):e112483. PMID: 25390655.
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      54. Hung MJ, Hsu KH, Chang NC, Tsimikas S, Hung MY. Prevalence of coronary artery spasm after stent placement and its association with inflammation. Int J Cardiol. 2015 Jan 20; 179:252-5. PMID: 25464459.
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      55. Pechlaner R, Willeit P, Summerer M, Santer P, Egger G, Kronenberg F, Demetz E, Weiss G, Tsimikas S, Witztum JL, Willeit K, Iglseder B, Paulweber B, Kedenko L, Haun M, Meisinger C, Gieger C, Müller-Nurasyid M, Peters A, Willeit J, Kiechl S. Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):229-36. PMID: 25359861.
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      56. Briley-Saebo K, Yeang C, Witztum JL, Tsimikas S. Imaging of oxidation-specific epitopes with targeted nanoparticles to detect high-risk atherosclerotic lesions: progress and future directions. J Cardiovasc Transl Res. 2014 Nov; 7(8):719-36. PMID: 25297940.
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      57. Tsimikas S. Lipoprotein Apheresis and Acute Reduction of Arterial Inflammation: FDG-PET as an Imaging Biomarker of Nonpharmacological Effects on the Vessel Wall. J Am Coll Cardiol. 2014 Oct 7; 64(14):1427-9. PMID: 25277611.
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      58. Willeit P, Kiechl S, Kronenberg F, Witztum JL, Santer P, Mayr M, Xu Q, Mayr A, Willeit J, Tsimikas S. Discrimination and Net Reclassification of Cardiovascular Risk With Lipoprotein(a): Prospective 15-Year Outcomes in the Bruneck Study. J Am Coll Cardiol. 2014 Sep 2; 64(9):851-60. PMID: 25169167.
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      59. Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum JL, Hartvigsen K. Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine. J Lipid Res. 2014 Oct; 55(10):2137-55. PMID: 25143462.
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      60. Sniderman AD, Tsimikas S, Fazio S. The severe hypercholesterolemia phenotype: clinical diagnosis, management, and emerging therapies. J Am Coll Cardiol. 2014 May 20; 63(19):1935-47. PMID: 24632267.
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      61. Nguyen TH, Bryant H, Shapsa A, Street H, Mani V, Fayad ZA, Frank JA, Tsimikas S, Briley-Saebo KC. Manganese G8 dendrimers targeted to oxidation-specific epitopes: In vivo MR imaging of atherosclerosis. J Magn Reson Imaging. 2015 Mar; 41(3):797-805. PMID: 24610640.
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      62. Ravandi A, Leibundgut G, Hung MY, Patel M, Hutchins PM, Murphy RC, Prasad A, Mahmud E, Miller YI, Dennis EA, Witztum JL, Tsimikas S. Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. J Am Coll Cardiol. 2014 May 20; 63(19):1961-71. PMID: 24613321.
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      63. DeMaria AN, Adler ED, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall JL, Hlatky MA, Lew WY, Lima JA, Mahmud E, Maisel AS, Narayan SM, Nissen SE, Sahn DJ, Tsimikas S. Highlights of the year in JACC 2013. J Am Coll Cardiol. 2014 Feb 18; 63(6):570-602. PMID: 24524815.
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      64. Tsimikas S, Duff GW, Berger PB, Rogus J, Huttner K, Clopton P, Brilakis E, Kornman KS, Witztum JL. Pro-Inflammatory Interleukin-1 Genotypes Potentiate the Risk of Coronary Artery Disease and Cardiovascular Events Mediated by Oxidized Phospholipids and Lipoprotein(a). J Am Coll Cardiol. 2014 May 6; 63(17):1724-34. PMID: 24530664.
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      65. Choi SH, Yin H, Ravandi A, Armando A, Dumlao D, Kim J, Almazan F, Taylor AM, McNamara CA, Tsimikas S, Dennis EA, Witztum JL, Miller YI. Polyoxygenated Cholesterol Ester Hydroperoxide Activates TLR4 and SYK Dependent Signaling in Macrophages. PLoS One. 2013; 8(12):e83145. PMID: 24376657.
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      66. Hung MY, Witztum JL, Tsimikas S. New Therapeutic Targets for Calcific Aortic Valve Stenosis: The Lipoprotein(a)-Lipoprotein-Associated Phospholipase A2-Oxidized Phospholipid Axis. J Am Coll Cardiol. 2014 Feb 11; 63(5):478-80. PMID: 24161316.
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      67. O'Donoghue ML, Morrow DA, Tsimikas S, Sloan S, Ren AF, Hoffman EB, Desai NR, Solomon SD, Domanski M, Arai K, Chiuve SE, Cannon CP, Sacks FM, Sabatine MS. Lipoprotein(a) for Risk Assessment in Patients With Established Coronary Artery Disease. J Am Coll Cardiol. 2014 Feb 18; 63(6):520-7. PMID: 24161323.
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      68. Perry HM, Oldham SN, Fahl SP, Que X, Gonen A, Harmon DB, Tsimikas S, Witztum JL, Bender TP, McNamara CA. Helix-loop-helix factor inhibitor of differentiation 3 regulates interleukin-5 expression and B-1a B cell proliferation. Arterioscler Thromb Vasc Biol. 2013 Dec; 33(12):2771-9. PMID: 24115031.
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      69. Ye Z, Haycock PC, Gurdasani D, Pomilla C, Boekholdt SM, Tsimikas S, Khaw KT, Wareham NJ, Sandhu MS, Forouhi NG. The Association Between Circulating Lipoprotein(a) and Type 2 Diabetes: Is It Causal? Diabetes. 2014 Jan; 63(1):332-42. PMID: 24089516.
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      70. Miller YI, Tsimikas S. Oxidation-specific epitopes as targets for biotheranostic applications in humans: biomarkers, molecular imaging and therapeutics. Curr Opin Lipidol. 2013 Oct; 24(5):426-37. PMID: 23995232.
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      85. Holleboom AG, Daniil G, Fu X, Zhang R, Hovingh GK, Schimmel AW, Kastelein JJ, Stroes ES, Witztum JL, Hutten BA, Tsimikas S, Hazen SL, Chroni A, Kuivenhoven JA. Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations. Arterioscler Thromb Vasc Biol. 2012 Dec; 32(12):3066-75. PMID: 23023370.
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      96. Tsimikas S, DeMaria AN. The clinical emergence of optical coherence tomography: defining a role in intravascular imaging. J Am Coll Cardiol. 2012 Mar 20; 59(12):1090-2. PMID: 22421302.
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      99. Demaria AN, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall J, Hlatky M, Lew WY, Lima JA, Maisel AS, Narayan SM, Nissen S, Sahn DJ, Tsimikas S. Highlights of the Year in JACC 2011. J Am Coll Cardiol. 2012 Jan 31; 59(5):503-37. PMID: 22281255.
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      102. Fefer P, Tsimikas S, Segev A, Sparkes J, Otsuma F, Kolodgie F, Virmani R, Juliano J, Charron T, Strauss BH. The role of oxidized phospholipids, lipoprotein (a) and biomarkers of oxidized lipoproteins in chronically occluded coronary arteries in sudden cardiac death and following successful percutaneous revascularization. Cardiovasc Revasc Med. 2012 Jan-Feb; 13(1):11-9. PMID: 22079685.
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      103. Doran AC, Lipinski MJ, Oldham SN, Garmey JC, Campbell KA, Skaflen MD, Cutchins A, Lee DJ, Glover DK, Kelly KA, Galkina EV, Ley K, Witztum JL, Tsimikas S, Bender TP, McNamara CA. B-cell aortic homing and atheroprotection depend on Id3. Circ Res. 2012 Jan 6; 110(1):e1-12. PMID: 22034493.
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      105. Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature. 2011 Oct 6; 478(7367):76-81. PMID: 21979047.
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      106. Vucic E, Dickson SD, Calcagno C, Rudd JH, Moshier E, Hayashi K, Mounessa JS, Roytman M, Moon MJ, Lin J, Tsimikas S, Fisher EA, Nicolay K, Fuster V, Fayad ZA. Pioglitazone modulates vascular inflammation in atherosclerotic rabbits noninvasive assessment with FDG-PET-CT and dynamic contrast-enhanced MR imaging. JACC Cardiovasc Imaging. 2011 Oct; 4(10):1100-9. PMID: 21999870.
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      108. Davidson MH, Ballantyne CM, Jacobson TA, Bittner VA, Braun LT, Brown AS, Brown WV, Cromwell WC, Goldberg RB, McKenney JM, Remaley AT, Sniderman AD, Toth PP, Tsimikas S, Ziajka PE, Maki KC, Dicklin MR. Clinical utility of inflammatory markers and advanced lipoprotein testing: advice from an expert panel of lipid specialists. J Clin Lipidol. 2011 Sep-Oct; 5(5):338-67. PMID: 21981835.
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      111. Prasad A, Ilapakurti M, Hu P, Zafar N, Palakodeti V, Tsimikas S, Mahmud E. Renal artery plaque composition is associated with changes in renal frame count following renal artery stenting. J Invasive Cardiol. 2011 Jun; 23(6):227-31. PMID: 21646647.
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      113. DeMaria AN, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall J, Hlatky M, Lew WY, Lima JA, Maisel AS, Narayan SM, Nissen S, Sahn DJ, Tsimikas S. Highlights of the year in JACC 2010. J Am Coll Cardiol. 2011 Jan 25; 57(4):480-514. PMID: 21251590.
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      117. Briley-Saebo KC, Cho YS, Shaw PX, Ryu SK, Mani V, Dickson S, Izadmehr E, Green S, Fayad ZA, Tsimikas S. Targeted iron oxide particles for in vivo magnetic resonance detection of atherosclerotic lesions with antibodies directed to oxidation-specific epitopes. J Am Coll Cardiol. 2011 Jan 18; 57(3):337-47. PMID: 21106318.
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      118. Ryu SK, Hutten BA, Vissers MN, Wiegman A, Kastelein JJ, Tsimikas S. Lipoprotein-associated phospholipase A2 mass and activity in children with heterozygous familial hypercholesterolemia and unaffected siblings: effect of pravastatin. J Clin Lipidol. 2011 Jan-Feb; 5(1):50-6. PMID: 21262507.
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      132. Budoff MJ, Ahmadi N, Gul KM, Liu ST, Flores FR, Tiano J, Takasu J, Miller E, Tsimikas S. Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial. Prev Med. 2009 Aug-Sep; 49(2-3):101-7. PMID: 19573556.
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      134. Ryu SK, Mahmud E, Tsimikas S. Estrogen-eluting stents. J Cardiovasc Transl Res. 2009 Sep; 2(3):240-4. PMID: 19654888.
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      136. Ohshima S, Petrov A, Fujimoto S, Zhou J, Azure M, Edwards DS, Murohara T, Narula N, Tsimikas S, Narula J. Molecular imaging of matrix metalloproteinase expression in atherosclerotic plaques of mice deficient in apolipoprotein e or low-density-lipoprotein receptor. J Nucl Med. 2009 Apr; 50(4):612-7. PMID: 19289429.
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      139. Berliner JA, Leitinger N, Tsimikas S. The role of oxidized phospholipids in atherosclerosis. J Lipid Res. 2009 Apr; 50 Suppl:S207-12. PMID: 19059906.
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      141. Kiechl S, Lee T, Santer P, Thompson G, Tsimikas S, Egger G, Holt DW, Willeit J, Xu Q, Mayr M. Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population. Atherosclerosis. 2009 Jul; 205(1):261-5. PMID: 19100547.
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      144. Prasad A, Tsimikas S. Candidate biomarkers for the detection of coronary plaque destabilization and rupture. Curr Atheroscler Rep. 2008 Aug; 10(4):309-17. PMID: 18618976.
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      145. Merki E, Graham MJ, Mullick AE, Miller ER, Crooke RM, Pitas RE, Witztum JL, Tsimikas S. Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice. Circulation. 2008 Aug 12; 118(7):743-53. PMID: 18663084.
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      146. Choi SH, Chae A, Miller E, Messig M, Ntanios F, DeMaria AN, Nissen SE, Witztum JL, Tsimikas S. Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study. J Am Coll Cardiol. 2008 Jul 1; 52(1):24-32. PMID: 18582631.
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      147. Bergmark C, Dewan A, Orsoni A, Merki E, Miller ER, Shin MJ, Binder CJ, Hörkkö S, Krauss RM, Chapman MJ, Witztum JL, Tsimikas S. A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma. J Lipid Res. 2008 Oct; 49(10):2230-9. PMID: 18594118.
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      148. Choi SH, Prasad A, Tsimikas S. The evolution of thienopyridine therapy clopidogrel duration, diabetes, and drug-eluting stents. J Am Coll Cardiol. 2008 Jun 10; 51(23):2228-9. PMID: 18534268.
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      149. Briley-Saebo KC, Shaw PX, Mulder WJ, Choi SH, Vucic E, Aguinaldo JG, Witztum JL, Fuster V, Tsimikas S, Fayad ZA. Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation. 2008 Jun 24; 117(25):3206-15. PMID: 18541740.
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      150. Mahmud E, Smith TW, Palakodeti V, Zaidi O, Ang L, Mitchell CR, Zafar N, Bromberg-Marin G, Keramati S, Tsimikas S. Renal frame count and renal blush grade: quantitative measures that predict the success of renal stenting in hypertensive patients with renal artery stenosis. JACC Cardiovasc Interv. 2008 Jun; 1(3):286-92. PMID: 19463314.
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      151. Tsimikas S. In vivo markers of oxidative stress and therapeutic interventions. Am J Cardiol. 2008 May 22; 101(10A):34D-42D. PMID: 18474272.
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      152. Cavendish JJ, Carter LI, Tsimikas S. Recent advances in hemodynamics: noncoronary applications of a pressure sensor angioplasty guidewire. Catheter Cardiovasc Interv. 2008 May 1; 71(6):748-58. PMID: 18324696.
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      153. Ky B, Burke A, Tsimikas S, Wolfe ML, Tadesse MG, Szapary PO, Witztum JL, FitzGerald GA, Rader DJ. The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. J Am Coll Cardiol. 2008 Apr 29; 51(17):1653-62. PMID: 18436117.
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      154. DeMaria AN, Bax JJ, Ben-Yehuda O, Clopton P, Feld GK, Ginsburg GS, Greenberg BH, Knoke JD, Lew WY, Lima JA, Maisel AS, Narayan SM, Narula J, Sahn DJ, Tsimikas S. Highlights of the year in JACC 2007. J Am Coll Cardiol. 2008 Jan 29; 51(4):490-512. PMID: 18222362.
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      155. Bossola M, Tazza L, Merki E, Giungi S, Luciani G, Miller ER, Lin EB, Tortorelli A, Tsimikas S. Oxidized low-density lipoprotein biomarkers in patients with end-stage renal failure: acute effects of hemodialysis. Blood Purif. 2007; 25(5-6):457-65. PMID: 18075247.
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      156. Tsimikas S, Tsironis LD, Tselepis AD. New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2007 Oct; 27(10):2094-9. PMID: 17626905.
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      157. Kiechl S, Willeit J, Mayr M, Viehweider B, Oberhollenzer M, Kronenberg F, Wiedermann CJ, Oberthaler S, Xu Q, Witztum JL, Tsimikas S. Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study. Arterioscler Thromb Vasc Biol. 2007 Aug; 27(8):1788-95. PMID: 17541022.
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      158. Mahmud E, Cavendish JJ, Tsimikas S, Ang L, Nguyen C, Bromberg-Marin G, Schnyder G, Keramati S, Palakodeti V, Penny WF, DeMaria AN. Elevated plasma fibrinogen level predicts suboptimal response to therapy with both single- and double-bolus eptifibatide during percutaneous coronary intervention. J Am Coll Cardiol. 2007 Jun 5; 49(22):2163-71. PMID: 17543636.
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      159. Bromberg-Marin G, Mahmud E, Tsimikas S. Spontaneous multivessel coronary vasospasm leading to cardiogenic shock. J Invasive Cardiol. 2007 Apr; 19(4):E85-8. PMID: 17404410.
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      160. Bromberg-Marin G, Tsimikas S, Mahmud E. Treatment of recurrent pulmonary vein stenoses with endovascular stenting and adjuvant oral sirolimus. Catheter Cardiovasc Interv. 2007 Feb 15; 69(3):362-8. PMID: 17200960.
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      161. Torzewski M, Ochsenhirt V, Kleschyov AL, Oelze M, Daiber A, Li H, Rossmann H, Tsimikas S, Reifenberg K, Cheng F, Lehr HA, Blankenberg S, Förstermann U, Münzel T, Lackner KJ. Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2007 Apr; 27(4):850-7. PMID: 17255533.
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      162. Choi SH, Chae A, Chen CH, Merki E, Shaw PX, Tsimikas S. Emerging approaches for imaging vulnerable plaques in patients. Curr Opin Biotechnol. 2007 Feb; 18(1):73-82. PMID: 17234398.
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      163. DeMaria AN, Ben-Yehuda O, Feld GK, Ginsburg GS, Greenberg BH, Lew WY, Lima JA, Maisel AS, Narula J, Sahn DJ, Tsimikas S. Highlights of the Year in JACC 2006. J Am Coll Cardiol. 2007 Jan 30; 49(4):509-27. PMID: 17258099.
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      164. Tsimikas S, Brilakis ES, Lennon RJ, Miller ER, Witztum JL, McConnell JP, Kornman KS, Berger PB. Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events. J Lipid Res. 2007 Feb; 48(2):425-33. PMID: 17093289.
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      165. Tsimikas S, Aikawa M, Miller FJ, Miller ER, Torzewski M, Lentz SR, Bergmark C, Heistad DD, Libby P, Witztum JL. Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. Arterioscler Thromb Vasc Biol. 2007 Jan; 27(1):175-81. PMID: 17082490.
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      166. Fraley AE, Tsimikas S. Clinical applications of circulating oxidized low-density lipoprotein biomarkers in cardiovascular disease. Curr Opin Lipidol. 2006 Oct; 17(5):502-9. PMID: 16960498.
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      167. Tsimikas S. Oxidative biomarkers in the diagnosis and prognosis of cardiovascular disease. Am J Cardiol. 2006 Dec 4; 98(11A):9P-17P. PMID: 17126679.
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      168. Tsimikas S. Measures of oxidative stress. Clin Lab Med. 2006 Sep; 26(3):571-90, v-vi. PMID: 16938585.
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      169. Isobe S, Tsimikas S, Zhou J, Fujimoto S, Sarai M, Branks MJ, Fujimoto A, Hofstra L, Reutelingsperger CP, Murohara T, Virmani R, Kolodgie FD, Narula N, Petrov A, Narula J. Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5. J Nucl Med. 2006 Sep; 47(9):1497-505. PMID: 16954559.
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      170. Ito MK, Talbert RL, Tsimikas S. Statin-associated pleiotropy: possible beneficial effects beyond cholesterol reduction. Pharmacotherapy. 2006 Jul; 26(7 Pt 2):85S-97S; discussion 98S-101S; quiz 106S-108S. PMID: 16803418.
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      171. Siddiqui DS, Choi CJ, Tsimikas S, Mahmud E. Successful utilization of a novel aspiration thrombectomy catheter (Pronto) for the treatment of patients with stent thrombosis. Catheter Cardiovasc Interv. 2006 Jun; 67(6):894-9. PMID: 16649245.
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      172. Mayr M, Kiechl S, Tsimikas S, Miller E, Sheldon J, Willeit J, Witztum JL, Xu Q. Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study. J Am Coll Cardiol. 2006 Jun 20; 47(12):2436-43. PMID: 16781371.
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      173. Tsimikas S, Kiechl S, Willeit J, Mayr M, Miller ER, Kronenberg F, Xu Q, Bergmark C, Weger S, Oberhollenzer F, Witztum JL. Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study. J Am Coll Cardiol. 2006 Jun 6; 47(11):2219-28. PMID: 16750687.
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      174. Tsimikas S, Willerson JT, Ridker PM. C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J Am Coll Cardiol. 2006 Apr 18; 47(8 Suppl):C19-31. PMID: 16631506.
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      175. DeMaria AN, Narula J, Mahmud E, Tsimikas S. Imaging vulnerable plaque by ultrasound. J Am Coll Cardiol. 2006 Apr 18; 47(8 Suppl):C32-9. PMID: 16631508.
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      176. Rodenburg J, Vissers MN, Wiegman A, Miller ER, Ridker PM, Witztum JL, Kastelein JJ, Tsimikas S. Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin. J Am Coll Cardiol. 2006 May 2; 47(9):1803-10. PMID: 16682304.
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      177. Tsimikas S. Drug-eluting stents and late adverse clinical outcomes lessons learned, lessons awaited. J Am Coll Cardiol. 2006 May 16; 47(10):2112-5. PMID: 16697332.
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      178. Mahmud E, Brocato M, Palakodeti V, Tsimikas S. Fibromuscular dysplasia of renal arteries: percutaneous revascularization based on hemodynamic assessment with a pressure measurement guidewire. Catheter Cardiovasc Interv. 2006 Mar; 67(3):434-7. PMID: 16475187.
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      179. Tsimikas S. Oxidized low-density lipoprotein biomarkers in atherosclerosis. Curr Atheroscler Rep. 2006 Jan; 8(1):55-61. PMID: 16455015.
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      180. Demaria AN, Ben-Yehuda O, Berman D, Feld GK, Ginsberg J, Greenberg BH, Lew WY, Sahn D, Tsimikas S. Highlights of the Year in JACC 2005. J Am Coll Cardiol. 2006 Jan 3; 47(1):184-202. PMID: 16386685.
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      181. Guillinta P, Waltman T, Tsimikas S. Rapid progression of common femoral artery stenosis leading to development of ischemic foot ulcer following repeated ipsilateral arterial access. Catheter Cardiovasc Interv. 2005 Dec; 66(4):487-90. PMID: 16273576.
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      182. Segev A, Strauss BH, Witztum JL, Lau HK, Tsimikas S. Relationship of a comprehensive panel of plasma oxidized low-density lipoprotein markers to angiographic restenosis in patients undergoing percutaneous coronary intervention for stable angina. Am Heart J. 2005 Nov; 150(5):1007-14. PMID: 16290986.
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      183. Serry R, Tsimikas S, Imbesi SG, Mahmud E. Treatment of ischemic stroke complicating cardiac catheterization with systemic thrombolytic therapy. Catheter Cardiovasc Interv. 2005 Nov; 66(3):364-8. PMID: 16208693.
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      184. Shortal BP, Mahmud E, Tsimikas S. Catheter-induced vasospasm of both the right external iliac and right coronary arteries during coronary angiography. Int J Cardiovasc Imaging. 2005 Oct; 21(5):481-5. PMID: 16175434.
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      185. Bisoendial RJ, Hovingh GK, El Harchaoui K, Levels JH, Tsimikas S, Pu K, Zwinderman AE, Kuivenhoven JA, Kastelein JJ, Stroes ES. Consequences of cholesteryl ester transfer protein inhibition in patients with familial hypoalphalipoproteinemia. Arterioscler Thromb Vasc Biol. 2005 Sep; 25(9):e133-4. PMID: 16127020.
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      186. Tsimikas S, Brilakis ES, Miller ER, McConnell JP, Lennon RJ, Kornman KS, Witztum JL, Berger PB. Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med. 2005 Jul 7; 353(1):46-57. PMID: 16000355.
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      187. Mahmud E, Keramati S, Salami A, Palakodeti V, Tsimikas S. Expanded applications of rotational atherectomy in contemporary coronary and peripheral interventional practice. J Invasive Cardiol. 2005 Apr; 17(4):207-10. PMID: 15831974.
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      188. Tsimikas S. Transcatheter closure of patent foramen ovale for migraine prophylaxis: hope or hype? J Am Coll Cardiol. 2005 Feb 15; 45(4):496-8. PMID: 15708693.
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      189. Schneider M, Witztum JL, Young SG, Ludwig EH, Miller ER, Tsimikas S, Curtiss LK, Marcovina SM, Taylor JM, Lawn RM, Innerarity TL, Pitas RE. High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. J Lipid Res. 2005 Apr; 46(4):769-78. PMID: 15654123.
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      190. Demaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton KU, Lew WY, Narula J, Sahn D, Tsimikas S. Highlights of the year in JACC 2004. J Am Coll Cardiol. 2005 Jan 4; 45(1):137-53. PMID: 15629388.
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      191. Torzewski M, Shaw PX, Han KR, Shortal B, Lackner KJ, Witztum JL, Palinski W, Tsimikas S. Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization. Arterioscler Thromb Vasc Biol. 2004 Dec; 24(12):2307-12. PMID: 15528482.
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      192. Tsimikas S, Witztum JL, Miller ER, Sasiela WJ, Szarek M, Olsson AG, Schwartz GG. High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial. Circulation. 2004 Sep 14; 110(11):1406-12. PMID: 15353498.
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      193. Cavendish JJ, Berman BJ, Schnyder G, Kerber C, Mahmud E, Turi ZG, Blanchard D, Tsimikas S. Concomitant coronary and multiple arch vessel stenoses in patients treated with external beam radiation: pathophysiological basis and endovascular treatment. Catheter Cardiovasc Interv. 2004 Jul; 62(3):385-90. PMID: 15224309.
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      194. Tsimikas S, Lau HK, Han KR, Shortal B, Miller ER, Segev A, Curtiss LK, Witztum JL, Strauss BH. Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): short-term and long-term immunologic responses to oxidized low-density lipoprotein. Circulation. 2004 Jun 29; 109(25):3164-70. PMID: 15184281.
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      195. Cavendish JJ, Penny WF, Madani MM, Keramati S, Ben-Yehuda O, Blanchard DG, Mahmud E, Perricone A, Tsimikas S. Severe ostial saphenous vein graft disease leading to acute coronary syndromes following proximal aorto-saphenous anastomoses with the symmetry bypass connector device: is it a suture device or a "stent"? J Am Coll Cardiol. 2004 Jan 7; 43(1):133-9. PMID: 14715195.
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      196. DeMaria AN, Ben-Yehuda O, Berman D, Feld GK, Greenberg BH, Knoke JD, Knowlton KU, Lew WY, Tsimikas S. Highlights of the year in JACC 2003. J Am Coll Cardiol. 2003 Dec 17; 42(12):2156-66. PMID: 15560019.
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      197. Edelstein C, Pfaffinger D, Hinman J, Miller E, Lipkind G, Tsimikas S, Bergmark C, Getz GS, Witztum JL, Scanu AM. Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a). J Biol Chem. 2003 Dec 26; 278(52):52841-7. PMID: 14557258.
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      198. Sukhova GK, Zhang Y, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum JL, Lu ML, Sakara Y, Chin MT, Libby P, Shi GP. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003 Mar; 111(6):897-906. PMID: 12639996.
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      199. Tsimikas S, Bergmark C, Beyer RW, Patel R, Pattison J, Miller E, Juliano J, Witztum JL. Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes. J Am Coll Cardiol. 2003 Feb 5; 41(3):360-70. PMID: 12575961.
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      200. Tsimikas S, Witztum JL. Shifting the diagnosis and treatment of atherosclerosis to children and young adults: a new paradigm for the 21st century. J Am Coll Cardiol. 2002 Dec 18; 40(12):2122-4. PMID: 12505223.
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      201. Tsimikas S. Noninvasive imaging of oxidized low-density lipoprotein in atherosclerotic plaques with tagged oxidation-specific antibodies. Am J Cardiol. 2002 Nov 21; 90(10C):22L-27L. PMID: 12459423.
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      202. Palinski W, Tsimikas S. Immunomodulatory effects of statins: mechanisms and potential impact on arteriosclerosis. J Am Soc Nephrol. 2002 Jun; 13(6):1673-81. PMID: 12039998.
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      203. Tsimikas S, Shaw PX. Non-invasive imaging of vulnerable plaques by molecular targeting of oxidized LDL with tagged oxidation-specific antibodies. J Cell Biochem Suppl. 2002; 39:138-46. PMID: 12552613.
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      204. Tsimikas S, Beyer R, Hassankhani A. Relationship between the heparin management test and the HemoTec activated clotting time in patients undergoing percutaneous coronary intervention. J Thromb Thrombolysis. 2001 May; 11(3):217-21. PMID: 11577260.
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      205. Tsimikas S, Palinski W, Witztum JL. Circulating autoantibodies to oxidized LDL correlate with arterial accumulation and depletion of oxidized LDL in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2001 Jan; 21(1):95-100. PMID: 11145939.
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      206. Tsimikas S, Shortal BP, Witztum JL, Palinski W. In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression. Arterioscler Thromb Vasc Biol. 2000 Mar; 20(3):689-97. PMID: 10712392.
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      207. Tsimikas S, Palinski W, Halpern SE, Yeung DW, Curtiss LK, Witztum JL. Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo. J Nucl Cardiol. 1999 Jan-Feb; 6(1 Pt 1):41-53. PMID: 10070840.
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