Simon Schenk

Title(s)Professor, Orthopedic Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-8224-3203 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Diego, La JollaPost Doctoral08/2009Insulin Action
    University of Michigan, Ann ArborPh.D.04/2006Kinesiology
    University of Texas, AustinM.A.8/2002Exercise Physiology
    University of Queensland, Brisbane, AustraliaB. Applied Science11/1999Human Movement Studies
    Collapse Awards and Honors
    American College of Sports Medicine 2006Charles M. Tipton National Student Research Award
    Department of Orthopaedic Surgery, UC San Diego2019Basic Science Research Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Acetylation and contraction-mediated glucose uptake
    NIH R21AG067495Sep 30, 2021 - May 31, 2023
    Role: Principal Investigator
    Lysine acetylation and skeletal muscle insulin action
    NIH R56DK131121Sep 17, 2021 - Sep 16, 2022
    Role: Principal Investigator
    p300/CBP, acetylation and muscle force generation
    NIH R21AR072882May 15, 2018 - Feb 28, 2021
    Role: Principal Investigator
    SIRTI and Adaptive Muscle Growth
    NIH R21AR069775Mar 1, 2017 - Feb 29, 2020
    Role: Principal Investigator
    SIRT1 and muscle insulin sensitivity
    NIH R01AG043120Aug 1, 2012 - May 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The effect of tenotomy, neurotomy, and dual injury on mouse rotator cuff muscles: Consequences for the mouse as a preclinical model. J Orthop Res. 2024 Jan 21. Gibbons MC, Silldorff M, Okuno H, Esparza MC, Migdal C, Johnson S, Schenk S, Ward SR. PMID: 38245849.
      View in: PubMed   Mentions:    Fields:    
    2. Cancer-cell-secreted extracellular vesicles target p53 to impair mitochondrial function in muscle. EMBO Rep. 2023 09 06; 24(9):e56464. Ruan X, Cao M, Yan W, Jones YZ, Gustafsson ÅB, Patel HH, Schenk S, Wang SE. PMID: 37439436; PMCID: PMC10481655.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    3. Paraspinal muscle gene expression across different aetiologies in individuals undergoing surgery for lumbar spine pathology. Eur Spine J. 2023 04; 32(4):1123-1131. Ordaz A, Anderson B, Zlomislic V, Allen RT, Garfin SR, Schuepbach R, Farshad M, Schenk S, Ward SR, Shahidi B. PMID: 36740606; PMCID: PMC10448537.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. The Association of Metabolic Syndrome and Obesity With Clinical Hip Osteoarthritis in the Study of Osteoporotic Fractures and the Osteoporotic Fractures in Men Study Cohorts. ACR Open Rheumatol. 2023 Mar; 5(3):115-123. Cheng KY, Strotmeyer ES, Kado DM, Schousboe JT, Schenk S, Nevitt M, Lane NE, Hughes-Austin JM. PMID: 36694301; PMCID: PMC10010487.
      View in: PubMed   Mentions: 1  
    5. Paraspinal Muscle Health is Related to Fibrogenic, Adipogenic, and Myogenic Gene Expression in Patients with Lumbar Spine Pathology. BMC Musculoskelet Disord. 2022 Jun 24; 23(1):608. Anderson B, Ordaz A, Zlomislic V, Allen RT, Garfin SR, Schuepbach R, Farshad M, Schenk S, Ward SR, Shahidi B. PMID: 35739523; PMCID: PMC9229083.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    6. Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis. Nat Cell Biol. 2022 05; 24(5):793-804. Yan W, Cao M, Ruan X, Jiang L, Lee S, Lemanek A, Ghassemian M, Pizzo DP, Wan Y, Qiao Y, Chin AR, Duggan E, Wang D, Nolan JP, Esko JD, Schenk S, Wang SE. PMID: 35469018; PMCID: PMC9107513.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    7. p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes. JCI Insight. 2022 01 11; 7(1). Martins VF, LaBarge SA, Stanley A, Svensson K, Hung CW, Keinan O, Ciaraldi TP, Banoian D, Park JE, Ha C, Hetrick B, Meyer GA, Philp A, David LL, Henry RR, Aslan JE, Saltiel AR, McCurdy CE, Schenk S. PMID: 34813504; PMCID: PMC8765050.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    8. Interrupting Sitting Time in Postmenopausal Women: Protocol for the Rise for Health Randomized Controlled Trial. JMIR Res Protoc. 2021 May 13; 10(5):e28684. Hartman SJ, Dillon LW, LaCroix AZ, Natarajan L, Sears DD, Owen N, Dunstan DW, Sallis JF, Schenk S, Allison M, Takemoto M, Herweck AM, Nguyen B, Rosenberg DE. PMID: 33983131; PMCID: PMC8160808.
      View in: PubMed   Mentions: 1  
    9. Sirtuin 1 is not required for contraction-stimulated glucose uptake in mouse skeletal muscle. J Appl Physiol (1985). 2021 06 01; 130(6):1893-1902. Kang JH, Park JE, Dagoon J, Masson SWC, Merry TL, Bremner SN, Dent JR, Schenk S. PMID: 33886385; PMCID: PMC8285607.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    10. Quantifying the Effects of Aging on Morphological and Cellular Properties of Human Female Pelvic Floor Muscles. Ann Biomed Eng. 2021 Aug; 49(8):1836-1847. Rieger M, Duran P, Cook M, Schenk S, Shah M, Jacobs M, Christman K, Kado DM, Alperin M. PMID: 33683527; PMCID: PMC8376748.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Analgesic Medication Use During Exercise-Based Rehabilitation in Individuals With Low Back Pain: A Call to Action. Phys Ther. 2021 03 03; 101(3). Shahidi B, Schenk S, Raiszadeh K. PMID: 33454784; PMCID: PMC8005293.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Surgical site peptidylarginine deaminase 4 (PAD4), a biomarker of NETosis, correlates with insulin resistance in total joint arthroplasty patients: A preliminary report. PLoS One. 2021; 16(1):e0245594. Martins VF, Dobson CR, Begur M, Parekh J, Ball ST, Gonzalez F, Hughes-Austin JM, Schenk S. PMID: 33481860; PMCID: PMC7822240.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Skeletal muscle maximal mitochondrial activity in ambulatory children with cerebral palsy. Dev Med Child Neurol. 2021 10; 63(10):1194-1203. Dayanidhi S, Buckner EH, Redmond RS, Chambers HG, Schenk S, Lieber RL. PMID: 33393083.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    14. Metabolic Syndrome Is Associated With Higher Risk of Wound Complications After Total Hip Arthroplasty. Arthroplast Today. 2020 Sep; 6(3):571-577. Cheng KY, Ball ST, Gonzales FB, Schenk S, Hughes-Austin JM. PMID: 32802927; PMCID: PMC7419251.
      View in: PubMed   Mentions: 3  
    15. Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise. Cell. 2020 06 25; 181(7):1464-1474. Sanford JA, Nogiec CD, Lindholm ME, Adkins JN, Amar D, Dasari S, Drugan JK, Fernández FM, Radom-Aizik S, Schenk S, Snyder MP, Tracy RP, Vanderboom P, Trappe S, Walsh MJ, Molecular Transducers of Physical Activity Consortium. PMID: 32589957; PMCID: PMC8800485.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimals
    16. Maternal Obesity and Western-Style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates. Diabetes. 2020 07; 69(7):1389-1400. Campodonico-Burnett W, Hetrick B, Wesolowski SR, Schenk S, Takahashi DL, Dean TA, Sullivan EL, Kievit P, Gannon M, Aagaard K, Friedman JE, McCurdy CE. PMID: 32354857; PMCID: PMC7306120.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    17. p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival. J Cachexia Sarcopenia Muscle. 2020 04; 11(2):464-477. Svensson K, LaBarge SA, Sathe A, Martins VF, Tahvilian S, Cunliffe JM, Sasik R, Mahata SK, Meyer GA, Philp A, David LL, Ward SR, McCurdy CE, Aslan JE, Schenk S. PMID: 31898871; PMCID: PMC7113519.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    18. Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice. Am J Physiol Endocrinol Metab. 2020 02 01; 318(2):E145-E151. Svensson K, Tahvilian S, Martins VF, Dent JR, Lemanek A, Barooni N, Greyslak K, McCurdy CE, Schenk S. PMID: 31794263; PMCID: PMC7052578.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. Skeletal muscle mitochondrial function and exercise capacity are not impaired in mice with knockout of STAT3. J Appl Physiol (1985). 2019 10 01; 127(4):1117-1127. Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S. PMID: 31513449; PMCID: PMC6850983.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    20. Acute inhibition of protein deacetylases does not impact skeletal muscle insulin action. Am J Physiol Cell Physiol. 2019 11 01; 317(5):C964-C968. Martins VF, Begur M, Lakkaraju S, Svensson K, Park J, Hetrick B, McCurdy CE, Schenk S. PMID: 31461343; PMCID: PMC6879879.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    21. Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity. Am J Physiol Endocrinol Metab. 2019 06 01; 316(6):E1024-E1035. Martins VF, Dent JR, Svensson K, Tahvilian S, Begur M, Lakkaraju S, Buckner EH, LaBarge SA, Hetrick B, McCurdy CE, Schenk S. PMID: 30888860; PMCID: PMC6620570.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    22. Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution. Proc Biol Sci. 2018 09 12; 285(1886). Okerblom J, Fletes W, Patel HH, Schenk S, Varki A, Breen EC. PMID: 30209232; PMCID: PMC6158528.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    23. Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action. Am J Physiol Endocrinol Metab. 2018 11 01; 315(5):E1034-E1045. Svensson K, Dent JR, Tahvilian S, Martins VF, Sathe A, Ochala J, Patel MS, Schenk S. PMID: 30153068; PMCID: PMC6293170.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    24. Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase. Front Physiol. 2018; 9:789. Martins VF, Tahvilian S, Kang JH, Svensson K, Hetrick B, Chick WS, Schenk S, McCurdy CE. PMID: 29997524; PMCID: PMC6030672.
      View in: PubMed   Mentions: 7  
    25. Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle. Am J Physiol Endocrinol Metab. 2018 08 01; 315(2):E267-E278. Hernandez-Carretero A, Weber N, LaBarge SA, Peterka V, Doan NYT, Schenk S, Osborn O. PMID: 29634311; PMCID: PMC6139493.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    26. SIRT1 regulates nuclear number and domain size in skeletal muscle fibers. J Cell Physiol. 2018 09; 233(9):7157-7163. Ross JA, Levy Y, Svensson K, Philp A, Schenk S, Ochala J. PMID: 29574748; PMCID: PMC5993587.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    27. Heterogeneous muscle gene expression patterns in patients with massive rotator cuff tears. PLoS One. 2018; 13(1):e0190439. Gibbons MC, Fisch KM, Pichika R, Cheng T, Engler AJ, Schenk S, Lane JG, Singh A, Ward SR. PMID: 29293645; PMCID: PMC5749784.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    28. Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial. PLoS One. 2017; 12(11):e0188544. Kerr J, Crist K, Vital DG, Dillon L, Aden SA, Trivedi M, Castellanos LR, Godbole S, Li H, Allison MA, Khemlina GL, Takemoto ML, Schenk S, Sallis JF, Grace M, Dunstan DW, Natarajan L, LaCroix AZ, Sears DD. PMID: 29190761; PMCID: PMC5708739.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    29. Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle. Sci Rep. 2017 10 18; 7(1):13485. Pérez-Schindler J, Kanhere A, Edwards L, Allwood JW, Dunn WB, Schenk S, Philp A. PMID: 29044196; PMCID: PMC5647435.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    30. Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab. 2017 12; 6(12):1574-1584. Dent JR, Martins VF, Svensson K, LaBarge SA, Schlenk NC, Esparza MC, Buckner EH, Meyer GA, Hamilton DL, Schenk S, Philp A. PMID: 29111103; PMCID: PMC5699915.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    31. Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3. Am J Physiol Cell Physiol. 2017 Sep 01; 313(3):C257-C261. Pérez-Schindler J, Esparza MC, McKendry J, Breen L, Philp A, Schenk S. PMID: 28659288; PMCID: PMC5625092.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    32. Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis. Acta Physiol (Oxf). 2017 Nov; 221(3):193-203. Svensson K, LaBarge SA, Martins VF, Schenk S. PMID: 28544355; PMCID: PMC5641221.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    33. Dried Plum Ingestion Increases the Osteoblastogenic Capacity of Human Serum. J Med Food. 2017 Jul; 20(7):653-658. Delgado Cuenca P, Almaiman L, Schenk S, Kern M, Hooshmand S. PMID: 28445075.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    34. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 06; 13(6):624-632. Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N. PMID: 28346406; PMCID: PMC5435566.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    35. Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK. EBioMedicine. 2017 Apr; 18:128-138. Park SJ, Ahmad F, Um JH, Brown AL, Xu X, Kang H, Ke H, Feng X, Ryall J, Philp A, Schenk S, Kim MK, Sartorelli V, Chung JH. PMID: 28396013; PMCID: PMC5405165.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    36. mTOR regulates peripheral nerve response to tensile strain. J Neurophysiol. 2017 05 01; 117(5):2075-2084. Love JM, Bober BG, Orozco E, White AT, Bremner SN, Lovering RM, Schenk S, Shah SB. PMID: 28250148; PMCID: PMC5434482.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    37. Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease. J Bone Joint Surg Am. 2017 Feb 01; 99(3):190-199. Gibbons MC, Singh A, Anakwenze O, Cheng T, Pomerantz M, Schenk S, Engler AJ, Ward SR. PMID: 28145949; PMCID: PMC5395080.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    38. Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight. 2016 Oct 06; 1(16):e86612. McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE. PMID: 27734025; PMCID: PMC5053156.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    39. Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy. Muscle Nerve. 2017 01; 55(1):122-124. Zogby AM, Dayanidhi S, Chambers HG, Schenk S, Lieber RL. PMID: 27515237; PMCID: PMC5173443.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    40. One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance. JCI Insight. 2016 09 22; 1(15):e88322. Gao MH, Giamouridis D, Lai NC, Walenta E, Paschoal VA, Kim YC, Miyanohara A, Guo T, Liao M, Liu L, Tan Z, Ciaraldi TP, Schenk S, Bhargava A, Oh DY, Hammond HK. PMID: 27699250; PMCID: PMC5033760.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    41. Muscle architectural changes after massive human rotator cuff tear. J Orthop Res. 2016 12; 34(12):2089-2095. Gibbons MC, Sato EJ, Bachasson D, Cheng T, Azimi H, Schenk S, Engler AJ, Singh A, Ward SR. PMID: 27061583; PMCID: PMC5423410.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    42. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. PMID: 27075628; PMCID: PMC4934679.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    43. p300 is not required for metabolic adaptation to endurance exercise training. FASEB J. 2016 Apr; 30(4):1623-33. LaBarge SA, Migdal CW, Buckner EH, Okuno H, Gertsman I, Stocks B, Barshop BA, Nalbandian SR, Philp A, McCurdy CE, Schenk S. PMID: 26712218; PMCID: PMC4799503.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    44. Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle. FASEB J. 2016 Feb; 30(2):674-87. Cho Y, Hazen BC, Gandra PG, Ward SR, Schenk S, Russell AP, Kralli A. PMID: 26481306; PMCID: PMC4714556.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    45. Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise. J Physiol. 2015 Sep 15; 593(18):4275-84. Philp A, Schenk S, Perez-Schindler J, Hamilton DL, Breen L, Laverone E, Jeromson S, Phillips SM, Baar K. PMID: 26227152; PMCID: PMC4594297.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    46. Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance. Mol Metab. 2015 Aug; 4(8):569-75. White AT, LaBarge SA, McCurdy CE, Schenk S. PMID: 26266089; PMCID: PMC4529495.
      View in: PubMed   Mentions: 18     Fields:    
    47. Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action? Mol Cells. 2015 Apr; 38(4):297-303. LaBarge S, Migdal C, Schenk S. PMID: 25824547; PMCID: PMC4400303.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    48. Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity. PLoS One. 2014; 9(9):e107487. Franck N, Maris M, Nalbandian S, Talukdar S, Schenk S, Hofmann HP, Bullough D, Osborn O. PMID: 25244011; PMCID: PMC4171490.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    49. Muscle gene expression patterns in human rotator cuff pathology. J Bone Joint Surg Am. 2014 Sep 17; 96(18):1558-65. Choo A, McCarthy M, Pichika R, Sato EJ, Lieber RL, Schenk S, Lane JG, Ward SR. PMID: 25232080; PMCID: PMC4159966.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    50. Interaction between lipid availability,endurance exercise and insulin sensitivity. Med Sport Sci. 2014; 60:62-70. Newsom SA, Schenk S. PMID: 25226801.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    51. Understanding the acetylome: translating targeted proteomics into meaningful physiology. Am J Physiol Cell Physiol. 2014 Nov 01; 307(9):C763-73. Philp A, Rowland T, Perez-Schindler J, Schenk S. PMID: 25186010; PMCID: PMC4216940.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    52. High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. Am J Physiol Endocrinol Metab. 2014 Nov 01; 307(9):E764-72. White AT, Philp A, Fridolfsson HN, Schilling JM, Murphy AN, Hamilton DL, McCurdy CE, Patel HH, Schenk S. PMID: 25159328; PMCID: PMC4216952.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    53. Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity. Cell. 2014 Jun 05; 157(6):1339-1352. Lee YS, Kim JW, Osborne O, Oh DY, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky JM. PMID: 24906151; PMCID: PMC4114226.
      View in: PubMed   Mentions: 265     Fields:    Translation:AnimalsCells
    54. Application of the [γ-32P] ATP kinase assay to study anabolic signaling in human skeletal muscle. J Appl Physiol (1985). 2014 Mar 01; 116(5):504-13. McGlory C, White A, Treins C, Drust B, Close GL, Maclaren DP, Campbell IT, Philp A, Schenk S, Morton JP, Hamilton DL. PMID: 24436296; PMCID: PMC4116398.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    55. Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle. Exerc Sport Sci Rev. 2013 Jul; 41(3):174-81. Philp A, Schenk S. PMID: 23792490; PMCID: PMC3707796.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    56. Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice. Diabetologia. 2013 Jul; 56(7):1629-37. White AT, McCurdy CE, Philp A, Hamilton DL, Johnson CD, Schenk S. PMID: 23604553; PMCID: PMC3703320.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    57. Role of the cytoskeleton in muscle transcriptional responses to altered use. Physiol Genomics. 2013 Apr 16; 45(8):321-31. Meyer GA, Schenk S, Lieber RL. PMID: 23444318; PMCID: PMC3633430.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    58. Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes. 2013 Feb; 62(2):401-10. Boon J, Hoy AJ, Stark R, Brown RD, Meex RC, Henstridge DC, Schenk S, Meikle PJ, Horowitz JF, Kingwell BA, Bruce CR, Watt MJ. PMID: 23139352; PMCID: PMC3554351.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    59. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. J Lipid Res. 2012 Dec; 53(12):2610-9. Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, Reue K, Spencer MJ, Newgard CB, Tontonoz P. PMID: 23028113; PMCID: PMC3494265.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    60. Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice. Diabetes. 2012 Oct; 61(10):2495-505. McCurdy CE, Schenk S, Holliday MJ, Philp A, Houck JA, Patsouris D, MacLean PS, Majka SM, Klemm DJ, Friedman JE. PMID: 22698915; PMCID: PMC3447911.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    61. G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest. 2012 Jul; 122(7):2444-53. Osborn O, Oh DY, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, Li P, Thiede L, Morinaga H, Kim JJ, Heinrichsdorff J, Nalbandian S, Ofrecio JM, Scadeng M, Schenk S, Hadcock J, Bartfai T, Olefsky JM. PMID: 22653059; PMCID: PMC3386820.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    62. NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E308-21. White AT, Schenk S. PMID: 22436696; PMCID: PMC3423123.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    63. Commentaries on viewpoint: does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments? J Appl Physiol (1985). 2012 Mar; 112(5):929-30. Menzies KJ, Chabi B, Hood DA, Schenk S, Philp A, Philip A, Braga VA, Guimaraes DD. PMID: 22383496.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    64. New opportunities and novel paradigms to support neuromuscular research. Phys Med Rehabil Clin N Am. 2012 Feb; 23(1):95-105, xi. Lieber R, Ward S, Frank L, Schenk S. PMID: 22239877.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    65. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest. 2011 Nov; 121(11):4281-8. Schenk S, McCurdy CE, Philp A, Chen MZ, Holliday MJ, Bandyopadhyay GK, Osborn O, Baar K, Olefsky JM. PMID: 21985785; PMCID: PMC3204844.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    66. The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes. Am J Physiol Regul Integr Comp Physiol. 2011 Oct; 301(4):R864-72. Philp A, Belew MY, Evans A, Pham D, Sivia I, Chen A, Schenk S, Baar K. PMID: 21795630; PMCID: PMC3197342.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    67. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem. 2011 Sep 02; 286(35):30561-30570. Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S. PMID: 21757760; PMCID: PMC3162416.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    68. High fatty acid availability after exercise alters the regulation of muscle lipid metabolism. Metabolism. 2011 Jun; 60(6):852-9. Newsom SA, Schenk S, Li M, Everett AC, Horowitz JF. PMID: 20870251; PMCID: PMC3011035.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    69. Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol. 2010 Jul; 24(7):1413-22. Lu M, Li P, Pferdekamper J, Fan W, Saberi M, Schenk S, Olefsky JM. PMID: 20444886; PMCID: PMC2903908.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    70. A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab. 2010 May; 298(5):E1036-48. Lu M, Patsouris D, Li P, Flores-Riveros J, Frincke JM, Watkins S, Schenk S, Olefsky JM. PMID: 20159859; PMCID: PMC2867370.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    71. Energy deficit after exercise augments lipid mobilization but does not contribute to the exercise-induced increase in insulin sensitivity. J Appl Physiol (1985). 2010 Mar; 108(3):554-60. Newsom SA, Schenk S, Thomas KM, Harber MP, Knuth ND, Goldenberg N, Horowitz JF. PMID: 20044472; PMCID: PMC2838634.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    72. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E419-28. Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, Oh DY, Lu M, Milne JC, Westphal C, Bandyopadhyay G, Olefsky JM. PMID: 19996381; PMCID: PMC2838524.
      View in: PubMed   Mentions: 195     Fields:    Translation:AnimalsCells
    73. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab. 2009 Nov; 10(5):419-29. Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, Bandyopadhyay G, Verma IM, Olefsky JM. PMID: 19883619; PMCID: PMC2790319.
      View in: PubMed   Mentions: 227     Fields:    Translation:AnimalsCells
    74. Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity. J Physiol. 2009 Oct 15; 587(Pt 20):4949-61. Schenk S, Harber MP, Shrivastava CR, Burant CF, Horowitz JF. PMID: 19723783; PMCID: PMC2770158.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    75. A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. J Biol Chem. 2009 Oct 16; 284(42):28498-509. Gayen JR, Saberi M, Schenk S, Biswas N, Vaingankar SM, Cheung WW, Najjar SM, O'Connor DT, Bandyopadhyay G, Mahata SK. PMID: 19706599; PMCID: PMC2781393.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    76. Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1137-46. Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G, Li P, Jadhar V, Vargeese C, Wang W, Bowman K, Zhang Y, Polisky B, Olefsky JM. PMID: 19706791; PMCID: PMC2781351.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    77. Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. J Med Chem. 2009 Mar 12; 52(5):1275-83. Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB. PMID: 19199480.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    78. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol. 2009 Mar; 29(5):1363-74. Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM. PMID: 19103747; PMCID: PMC2643824.
      View in: PubMed   Mentions: 195     Fields:    Translation:AnimalsCells
    79. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature. 2008 Nov 13; 456(7219):269-73. Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J, Olefsky J, Guarente L, Montminy M. PMID: 18849969; PMCID: PMC2597669.
      View in: PubMed   Mentions: 291     Fields:    Translation:HumansAnimalsCells
    80. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008 Sep; 118(9):2992-3002. Schenk S, Saberi M, Olefsky JM. PMID: 18769626; PMCID: PMC2522344.
      View in: PubMed   Mentions: 471     Fields:    Translation:HumansAnimalsCells
    81. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450(7170):712-6. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. PMID: 18046409; PMCID: PMC2753457.
      View in: PubMed   Mentions: 742     Fields:    Translation:HumansAnimalsCells
    82. Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance. J Clin Invest. 2007 Jun; 117(6):1690-8. Schenk S, Horowitz JF. PMID: 17510709; PMCID: PMC1866251.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansCells
    83. Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training. Am J Physiol Endocrinol Metab. 2006 Aug; 291(2):E254-60. Schenk S, Horowitz JF. PMID: 16670153.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    84. Effects of dietary carbohydrate restriction with high protein intake on protein metabolism and the somatotropic axis. J Clin Endocrinol Metab. 2005 Sep; 90(9):5175-81. Harber MP, Schenk S, Barkan AL, Horowitz JF. PMID: 15972575.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    85. Alterations in carbohydrate metabolism in response to short-term dietary carbohydrate restriction. Am J Physiol Endocrinol Metab. 2005 Aug; 289(2):E306-12. Harber MP, Schenk S, Barkan AL, Horowitz JF. PMID: 15797987.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsCTClinical Trials
    86. Postexercise insulin sensitivity is not impaired after an overnight lipid infusion. Am J Physiol Endocrinol Metab. 2005 Mar; 288(3):E519-25. Schenk S, Cook JN, Kaufman AE, Horowitz JF. PMID: 15522993.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCTClinical Trials
    87. Manipulation of dietary carbohydrate and muscle glycogen affects glucose uptake during exercise when fat oxidation is impaired by beta-adrenergic blockade. Am J Physiol Endocrinol Metab. 2004 Dec; 287(6):E1195-201. Zderic TW, Schenk S, Davidson CJ, Byerley LO, Coyle EF. PMID: 15315908.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    88. High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise. Am J Physiol Endocrinol Metab. 2004 Feb; 286(2):E217-25. Zderic TW, Davidson CJ, Schenk S, Byerley LO, Coyle EF. PMID: 14559721.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    89. Different glycemic indexes of breakfast cereals are not due to glucose entry into blood but to glucose removal by tissue. Am J Clin Nutr. 2003 Oct; 78(4):742-8. Schenk S, Davidson CJ, Zderic TW, Byerley LO, Coyle EF. PMID: 14522732.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsPHPublic HealthCTClinical Trials
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