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    Shu Chien

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0412
    CA La Jolla 92093
    Phone858-534-5195
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Locus-specific Imaging of Dynamic Histone Methylations during Reprogramming
      NIH/NIGMS R01GM125379Aug 3, 2017 - Apr 30, 2021
      Role: Co-Principal Investigator
      The Organizational Hub and Web Portal for the 4D Nucleome Network
      NIH/NCI U01CA200147Sep 1, 2015 - Aug 31, 2020
      Role: Principal Investigator
      Mechanism of Atheroprone Mechanotransduction Studied By Single Cell Imaging
      NIH/NHLBI R01HL121365Dec 20, 2013 - Nov 30, 2017
      Role: Principal Investigator
      Systems Biology Analyses for Hemodynamic Regulation of Vascular Homeostasis
      NIH/NHLBI R01HL108735Aug 24, 2012 - Jun 30, 2021
      Role: Principal Investigator
      Shear Regulation of MicroRNA Transportomes and Targetomes in Vascular Homeostasis
      NIH/NHLBI R01HL106579Jan 1, 2011 - Nov 30, 2018
      Role: Principal Investigator
      Integrative Bioengineering of Heart, Vessels, and Blood
      NIH/NHLBI T32HL105373Sep 20, 2010 - Aug 31, 2020
      Role: Principal Investigator
      Optimization of the Chemical-Physical Environments for Stem Cell Differentiation
      NIH/NHLBI R21HL104402Jul 1, 2010 - Jun 30, 2012
      Role: Principal Investigator
      UCSD MARC Program
      NIH/NIGMS T34GM087193Jun 1, 2009 - May 31, 2015
      Role: Principal Investigator
      Confocal Laser Scanning Biological Microscope Olympus Fv1000
      NIH/NCRR S10RR025630Apr 1, 2009 - Mar 31, 2010
      Role: Principal Investigator
      The Role of Phosphatases in EC Mechanotransduction
      NIH/NHLBI R01HL085159Jul 1, 2006 - Jun 30, 2011
      Role: Principal Investigator
      Mechanical Feedback on Cell Structure and Signaling
      NIH/NHLBI R01HL080518Feb 1, 2006 - Jan 31, 2011
      Role: Principal Investigator
      DETECTION AND MODELS OF TOXICANT EXPOSURE
      NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
      Role: Co-Investigator
      MECHANISMS OF REPERFUSION INDUCTION OF ROS AND IKK
      NIH/NHLBI R01HL062747Feb 8, 2000 - Jan 31, 2004
      Role: Principal Investigator
      Mechanical and Molecular Bases of Endothelial Remodeling
      NIH/NHLBI R01HL064382Sep 28, 1999 - Jul 31, 2011
      Role: Principal Investigator
      1997 BIOMEDICAL ENGINEERING SOCIETY FALL MEETING
      NIH/NHLBI R13HL058979Sep 1, 1997 - Aug 31, 1998
      Role: Principal Investigator
      Biomechanics of the Heart, Vessels, and Blood Cells
      NIH/NHLBI P01HL043026Jul 1, 1990 - May 31, 2007
      Role: Principal Investigator
      BLOOD CELL PROPERTIES AND CIRCULATORY REGULATION
      NIH/NHLBI R37HL044147May 1, 1989 - Apr 30, 2000
      Role: Principal Investigator
      RHEOLOGY IN CARDIOVASCULAR DISEASES
      NIH/NHLBI T32HL007114Jul 1, 1980 - Aug 31, 1990
      Role: Principal Investigator
      HUMAN BLOOD CELL MEMBRANES IN HEALTH AND DISEASE
      NIH/NHLBI P01HL016851Jun 1, 1979 - May 31, 1990
      Role: Principal Investigator
      Molecular Mechanism of Endothelial Migration Under Flow
      NIH/NHLBI R01HL019454Dec 1, 1976 - Jun 30, 2006
      Role: Principal Investigator
      Cardiovascular Engineering Science
      NIH/NHLBI T32HL007089Jul 1, 1975 - Oct 3, 2012
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Huang TS, Wang KC, Quon S, Nguyen P, Chang TY, Chen Z, Li YS, Subramaniam S, Shyy J, Chien S. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiol Genomics. 2017 Jul 01; 49(7):339-345. PMID: 28500253.
        View in: PubMed
      2. Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, Guan KL, Li YJ, Chien S. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci U S A. 2016 Oct 11; 113(41):11525-11530. PMID: 27671657.
        View in: PubMed
      3. Chien JY, Chien S, Chiu WY, Yu CJ, Hsueh PR. Moxifloxacin Improves Treatment Outcomes in Patients with Ofloxacin-Resistant Multidrug-Resistant Tuberculosis. Antimicrob Agents Chemother. 2016 Aug; 60(8):4708-16. PMID: 27216062; PMCID: PMC4958188 [Available on 02/01/17].
      4. Wu Y, Zhang K, Seong J, Fan J, Chien S, Wang Y, Lu S. In-situ coupling between kinase activities and protein dynamics within single focal adhesions. Sci Rep. 2016 Jul 07; 6:29377. PMID: 27383747; PMCID: PMC4935953.
      5. Bai KJ, Lee JJ, Chien S, Suk CW, Chiang CY. The Influence of Smoking on Pulmonary Tuberculosis in Diabetic and Non-Diabetic Patients. PLoS One. 2016; 11(6):e0156677. PMID: 27270725; PMCID: PMC4896632.
      6. Chien JY, Chiu WY, Chien S, Chiang CJ, Yu CJ, Hsueh PR. Mutations in gyrA and gyrB among Fluoroquinolone- and Multidrug-Resistant Mycobacterium tuberculosis Isolates. Antimicrob Agents Chemother. 2016 Apr; 60(4):2090-6. PMID: 26787695; PMCID: PMC4808166 [Available on 10/01/16].
      7. Ma X, Qu X, Zhu W, Li YS, Yuan S, Zhang H, Liu J, Wang P, Lai CS, Zanella F, Feng GS, Sheikh F, Chien S, Chen S. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2206-11. PMID: 26858399; PMCID: PMC4776497.
      8. Sun X, Fu Y, Gu M, Zhang L, Li D, Li H, Chien S, Shyy JY, Zhu Y. Activation of integrin a5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):769-74. PMID: 26733684; PMCID: PMC4725528.
      9. Hu CM, Fang RH, Wang KC, Luk BT, Thamphiwatana S, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, Carpenter C, Ramesh M, Qu V, Patel SH, Zhu J, Shi W, Hofman FM, Chen TC, Gao W, Zhang K, Chien S, Zhang L. Nanoparticle biointerfacing by platelet membrane cloaking. Nature. 2015 Oct 01; 526(7571):118-21. PMID: 26374997; PMCID: PMC4871317.
      10. Chien S, Bashir R, Nerem RM, Pettigrew R. Engineering as a new frontier for translational medicine. Sci Transl Med. 2015 Apr 01; 7(281):281fs13. PMID: 25834106; PMCID: PMC4698163.
      11. Chiang CY, Bai KJ, Lin HH, Chien S, Lee JJ, Enarson DA, Lee TI, Yu MC. The influence of diabetes, glycemic control, and diabetes-related comorbidities on pulmonary tuberculosis. PLoS One. 2015; 10(3):e0121698. PMID: 25822974; PMCID: PMC4378948.
      12. Teng D, Pannell JS, Rennert RC, Li J, Li YS, Wong VW, Chien S, Khalessi AA. Endothelial trauma from mechanical thrombectomy in acute stroke: in vitro live-cell platform with animal validation. Stroke. 2015 Apr; 46(4):1099-106. PMID: 25712942.
        View in: PubMed
      13. Chen LJ, Chuang L, Huang YH, Zhou J, Lim SH, Lee CI, Lin WW, Lin TE, Wang WL, Chen L, Chien S, Chiu JJ. MicroRNA mediation of endothelial inflammatory response to smooth muscle cells and its inhibition by atheroprotective shear stress. Circ Res. 2015 Mar 27; 116(7):1157-69. PMID: 25623956; PMCID: PMC4380766.
      14. Chien S. Laudatio for Harry Goldsmith. Biorheology. 2015; 52(5-6):295-9. PMID: 26639361.
        View in: PubMed
      15. Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller YI, Huang PH, Shyy JY. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. Circulation. 2015 Mar 03; 131(9):805-14. PMID: 25550450; PMCID: PMC4351177.
      16. Hu YL, Lu S, Szeto KW, Sun J, Wang Y, Lasheras JC, Chien S. FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells. Sci Rep. 2014 Aug 12; 4:6024. PMID: 25113375; PMCID: PMC4129417.
      17. Lu S, Seong J, Wang Y, Chang SC, Eichorst JP, Ouyang M, Li JY, Chien S, Wang Y. Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells. Sci Rep. 2014 Jul 24; 4:5756. PMID: 25056908; PMCID: PMC4108961.
      18. Fuhrmann A, Li J, Chien S, Engler AJ. Cation type specific cell remodeling regulates attachment strength. PLoS One. 2014; 9(7):e102424. PMID: 25014042; PMCID: PMC4094514.
      19. Lin YL, Chang KT, Lin CT, Tsai MJ, Tsai YA, Lee YY, Chien S, Huang WC, Shih YH, Cheng H, Huang MC. Repairing the ventral root is sufficient for simultaneous motor and sensory recovery in multiple complete cervical root transection injuries. Life Sci. 2014 Jul 25; 109(1):44-9. PMID: 24931903.
        View in: PubMed
      20. Zhou J, Li YS, Wang KC, Chien S. Epigenetic Mechanism in Regulation of Endothelial Function by Disturbed Flow: Induction of DNA Hypermethylation by DNMT1. Cell Mol Bioeng. 2014 Jun 01; 7(2):218-224. PMID: 24883126.
        View in: PubMed
      21. Zhou J, Li YS, Chien S. Shear stress-initiated signaling and its regulation of endothelial function. Arterioscler Thromb Vasc Biol. 2014 Oct; 34(10):2191-8. PMID: 24876354; PMCID: PMC4169328.
      22. Wang KC, Nguyen P, Weiss A, Yeh YT, Chien HS, Lee A, Teng D, Subramaniam S, Li YS, Chien S. MicroRNA-23b regulates cyclin-dependent kinase-activating kinase complex through cyclin H repression to modulate endothelial transcription and growth under flow. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1437-45. PMID: 24855060; PMCID: PMC4119726.
      23. Chiang CY, Lee JJ, Chien S, Enarson DA, Chang YC, Chen YT, Hu TY, Lin CB, Suk CW, Tao JM, Bai KJ. Glycemic control and radiographic manifestations of tuberculosis in diabetic patients. PLoS One. 2014; 9(4):e93397. PMID: 24699457; PMCID: PMC3974751.
      24. Lin CJ, Chen CP, Chien S, Lee CC, Town DD, Chen WL, Chen LF, Lee MS, Pan CW, Lin KC, Yeh TT. Chromosomal deletions detected at amniocentesis. Taiwan J Obstet Gynecol. 2014 Mar; 53(1):62-7. PMID: 24767649.
        View in: PubMed
      25. Shih YR, Hwang Y, Phadke A, Kang H, Hwang NS, Caro EJ, Nguyen S, Siu M, Theodorakis EA, Gianneschi NC, Vecchio KS, Chien S, Lee OK, Varghese S. Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):990-5. PMID: 24395775; PMCID: PMC3903237.
      26. Chien JY, Chien S, Huang SY, Yu CJ. Safety of rifabutin replacing rifampicin in the treatment of tuberculosis: a single-centre retrospective cohort study. J Antimicrob Chemother. 2014 Mar; 69(3):790-6. PMID: 24243988.
        View in: PubMed
      27. Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, Chiu JJ, Shyy JY, Chien S. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res. 2013 Jun 21; 113(1):40-51. PMID: 23603512; PMCID: PMC3772783.
      28. Yeh YT, Hur SS, Chang J, Wang KC, Chiu JJ, Li YS, Chien S. Matrix stiffness regulates endothelial cell proliferation through septin 9. PLoS One. 2012; 7(10):e46889. PMID: 23118862; PMCID: PMC3485289.
      29. DuRose JB, Li J, Chien S, Spector DH. Infection of vascular endothelial cells with human cytomegalovirus under fluid shear stress reveals preferential entry and spread of virus in flow conditions simulating atheroprone regions of the artery. J Virol. 2012 Dec; 86(24):13745-55. PMID: 23055562; PMCID: PMC3503096.
      30. Chien S. UCSD's Institute of Engineering in Medicine: fostering collaboration through research and education. IEEE Pulse. 2012 Jul; 3(4):35-41. PMID: 22850836.
        View in: PubMed
      31. Hur SS, del Álamo JC, Park JS, Li YS, Nguyen HA, Teng D, Wang KC, Flores L, Alonso-Latorre B, Lasheras JC, Chien S. Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11110-5. PMID: 22665785; PMCID: PMC3396533.
      32. Brafman DA, Chien S, Willert K. Arrayed cellular microenvironments for identifying culture and differentiation conditions for stem, primary and rare cell populations. Nat Protoc. 2012 Mar 15; 7(4):703-17. PMID: 22422316.
        View in: PubMed
      33. Altshuler AE, Morgan MJ, Chien S, Schmid-Schönbein GW. Proteolytic Activity Attenuates the Response of Endothelial Cells to Fluid Shear Stress. Cell Mol Bioeng. 2012 Mar; 5(1):82-91. PMID: 22545072.
        View in: PubMed
      34. Zhou J, Wang KC, Wu W, Subramaniam S, Shyy JY, Chiu JJ, Li JY, Chien S. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10355-60. PMID: 21636785; PMCID: PMC3121870.
      35. Chien S. A brief history of the Bioengineering Institute of California and the UC System-wide Symposia. Ann Biomed Eng. 2011 Apr; 39(4):1156-62. PMID: 21384235; PMCID: PMC3069316.
      36. Brafman DA, Chang CW, Fernandez A, Willert K, Varghese S, Chien S. Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. Biomaterials. 2010 Dec; 31(34):9135-44. PMID: 20817292; PMCID: PMC2949524.
      37. Lau CD, Levesque MJ, Chien S, Date S, Haga JH. ViewDock TDW: high-throughput visualization of virtual screening results. Bioinformatics. 2010 Aug 01; 26(15):1915-7. PMID: 20551133; PMCID: PMC2905552.
      38. Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S, Wang N, Shyy JY, Li YS, Chien S. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3234-9. PMID: 20133741; PMCID: PMC2840325.
      39. Yim WW, Chien S, Kusumoto Y, Date S, Haga J. Grid heterogeneity in in-silico experiments: an exploration of drug screening using DOCK on cloud environments. Stud Health Technol Inform. 2010; 159:181-90. PMID: 20543437.
        View in: PubMed
      40. Brafman DA, Shah KD, Fellner T, Chien S, Willert K. Defining long-term maintenance conditions of human embryonic stem cells with arrayed cellular microenvironment technology. Stem Cells Dev. 2009 Oct; 18(8):1141-54. PMID: 19327010.
        View in: PubMed
      41. Chien S. A Tribute to Professor Van C. Mow: A Wonderful Scholar and Leader in Bioengineering. Cell Mol Bioeng. 2009 Sep; 2(3):282-284. PMID: 19779632.
        View in: PubMed
      42. Young A, Wu W, Sun W, Benjamin Larman H, Larman HB, Wang N, Li YS, Shyy JY, Chien S, García-Cardeña G. Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1902-8. PMID: 19696400; PMCID: PMC2766008.
      43. Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24. PMID: 20023766.
        View in: PubMed
      44. del Alamo JC, Norwich GN, Li YS, Lasheras JC, Chien S. Anisotropic rheology and directional mechanotransduction in vascular endothelial cells. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15411-6. PMID: 18840694; PMCID: PMC2563098.
      45. Haga JH, Kaunas R, Radeff-Huang J, Weems JM, Estrada KD, Chien S, Brown JH, Seasholtz TM. Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation. Biochem Biophys Res Commun. 2008 Jul 18; 372(1):216-20. PMID: 18474218; PMCID: PMC2587448.
      46. Chien S. Role of shear stress direction in endothelial mechanotransduction. Mol Cell Biomech. 2008 Mar; 5(1):1-8. PMID: 18524241.
        View in: PubMed
      47. Flaim CJ, Teng D, Chien S, Bhatia SN. Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells Dev. 2008 Feb; 17(1):29-39. PMID: 18271698.
        View in: PubMed
      48. Chien S. Effects of disturbed flow on endothelial cells. Ann Biomed Eng. 2008 Apr; 36(4):554-62. PMID: 18172767; PMCID: PMC3718045.
      49. Hornberger TA, Sukhija KB, Wang XR, Chien S. mTOR is the rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr(389) in p70(S6k). FEBS Lett. 2007 Oct 02; 581(24):4562-6. PMID: 17825298; PMCID: PMC2084087.
      50. Hung CC, Chien S, Lin CY, Chang CH, Chang YF, Jong YJ, Hsieh ST, Hsieh WS, Liu MS, Lin WL, Lee CN, Su YN. Use of multiplex PCR and CE for gene dosage quantification and its biomedical applications for SMN, PMP22, and alpha-globin genes. Electrophoresis. 2007 Aug; 28(16):2826-34. PMID: 17640091.
        View in: PubMed
      51. Wang Y, Chang J, Chen KD, Li S, Li JY, Wu C, Chien S. Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8875-9. PMID: 17496149; PMCID: PMC1885595.
      52. D'Lima DD, Patil S, Steklov N, Chien S, Colwell CW. In vivo knee moments and shear after total knee arthroplasty. J Biomech. 2007; 40 Suppl 1:S11-7. PMID: 17462659.
        View in: PubMed
      53. Hu YL, Chien S. Dynamic motion of paxillin on actin filaments in living endothelial cells. Biochem Biophys Res Commun. 2007 Jun 15; 357(4):871-6. PMID: 17466945; PMCID: PMC2025639.
      54. Wu CC, Li YS, Haga JH, Kaunas R, Chiu JJ, Su FC, Usami S, Chien S. Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1254-9. PMID: 17229844; PMCID: PMC1783086.
      55. Chien S. Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. Am J Physiol Heart Circ Physiol. 2007 Mar; 292(3):H1209-24. PMID: 17098825.
        View in: PubMed
      56. Hung CC, Chen CP, Lin SP, Chien S, Lee CN, Cheng WF, Hsieh WS, Liu MS, Su YN, Lin WL. Quantitative assay of deletion or duplication genotype by capillary electrophoresis system: Application in Prader-Willi syndrome and Duchenne muscular dystrophy. Clin Chem. 2006 Dec; 52(12):2203-10. PMID: 17040959.
        View in: PubMed
      57. Hu YL, Haga JH, Miao H, Wang Y, Li YS, Chien S. Roles of microfilaments and microtubules in paxillin dynamics. Biochem Biophys Res Commun. 2006 Oct 06; 348(4):1463-71. PMID: 16920067.
        View in: PubMed
      58. Haga JH, Li YS, Chien S. Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells. J Biomech. 2007; 40(5):947-60. PMID: 16867303.
        View in: PubMed
      59. Hornberger TA, Sukhija KB, Chien S. Regulation of mTOR by mechanically induced signaling events in skeletal muscle. Cell Cycle. 2006 Jul; 5(13):1391-6. PMID: 16855395.
        View in: PubMed
      60. Hornberger TA, Chien S. Mechanical stimuli and nutrients regulate rapamycin-sensitive signaling through distinct mechanisms in skeletal muscle. J Cell Biochem. 2006 Apr 15; 97(6):1207-16. PMID: 16315321.
        View in: PubMed
      61. Wang N, Miao H, Li YS, Zhang P, Haga JH, Hu Y, Young A, Yuan S, Nguyen P, Wu CC, Chien S. Shear stress regulation of Krüppel-like factor 2 expression is flow pattern-specific. Biochem Biophys Res Commun. 2006 Mar 24; 341(4):1244-51. PMID: 16466697.
        View in: PubMed
      62. Wang Y, Jin G, Miao H, Li JY, Usami S, Chien S. Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1774-9. PMID: 16446427; PMCID: PMC1413667.
      63. Lorenzen-Schmidt I, Schmid-Schönbein GW, Giles WR, McCulloch AD, Chien S, Omens JH. Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear. Cell Biochem Biophys. 2006; 46(2):113-22. PMID: 17012753; PMCID: PMC3310206.
      64. Chien S. Molecular basis of rheological modulation of endothelial functions: importance of stress direction. Biorheology. 2006; 43(2):95-116. PMID: 16687781.
        View in: PubMed
      65. Kaunas R, Nguyen P, Usami S, Chien S. Cooperative effects of Rho and mechanical stretch on stress fiber organization. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):15895-900. PMID: 16247009; PMCID: PMC1276069.
      66. Li YS, Haga JH, Chien S. Molecular basis of the effects of shear stress on vascular endothelial cells. J Biomech. 2005 Oct; 38(10):1949-71. PMID: 16084198.
        View in: PubMed
      67. Chien S, Li S, Shiu YT, Li YS. Molecular basis of mechanical modulation of endothelial cell migration. Front Biosci. 2005 May 01; 10:1985-2000. PMID: 15769679.
        View in: PubMed
      68. Flaim CJ, Chien S, Bhatia SN. An extracellular matrix microarray for probing cellular differentiation. Nat Methods. 2005 Feb; 2(2):119-25. PMID: 15782209.
        View in: PubMed
      69. Miao H, Hu YL, Shiu YT, Yuan S, Zhao Y, Kaunas R, Wang Y, Jin G, Usami S, Chien S. Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigations. J Vasc Res. 2005 Jan-Feb; 42(1):77-89. PMID: 15637443.
        View in: PubMed
      70. Makino A, Glogauer M, Bokoch GM, Chien S, Schmid-Schönbein GW. Control of neutrophil pseudopods by fluid shear: role of Rho family GTPases. Am J Physiol Cell Physiol. 2005 Apr; 288(4):C863-71. PMID: 15561759.
        View in: PubMed
      71. Shiu YT, Li S, Marganski WA, Usami S, Schwartz MA, Wang YL, Dembo M, Chien S. Rho mediates the shear-enhancement of endothelial cell migration and traction force generation. Biophys J. 2004 Apr; 86(4):2558-65. PMID: 15041692; PMCID: PMC1304103.
      72. Chien S. The National Institute of Biomedical Imaging and Bioengineering. Annu Rev Biomed Eng. 2004; 6:1-26. PMID: 15255760.
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      73. Wang Y, Chang J, Li YC, Li YS, Shyy JY, Chien S. Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H685-92. PMID: 14551058.
        View in: PubMed
      74. Chien S. Molecular and mechanical bases of focal lipid accumulation in arterial wall. Prog Biophys Mol Biol. 2003 Oct; 83(2):131-51. PMID: 12865076.
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      75. Shiu YT, Li S, Yuan S, Wang Y, Nguyen P, Chien S. Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner. Biochem Biophys Res Commun. 2003 Apr 04; 303(2):548-55. PMID: 12659853.
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      76. Zhao Y, Chen BP, Miao H, Yuan S, Li YS, Hu Y, Rocke DM, Chien S. Improved significance test for DNA microarray data: temporal effects of shear stress on endothelial genes. Physiol Genomics. 2002 Dec 26; 12(1):1-11. PMID: 12399447.
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      77. Li S, Lao J, Chen BP, Li YS, Zhao Y, Chu J, Chen KD, Tsou TC, Peck K, Chien S. Genomic analysis of smooth muscle cells in 3-dimensional collagen matrix. FASEB J. 2003 Jan; 17(1):97-9. PMID: 12475912.
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      78. Hu YL, Li S, Miao H, Tsou TC, del Pozo MA, Chien S. Roles of microtubule dynamics and small GTPase Rac in endothelial cell migration and lamellipodium formation under flow. J Vasc Res. 2002 Nov-Dec; 39(6):465-76. PMID: 12566972.
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      79. Wang Y, Miao H, Li S, Chen KD, Li YS, Yuan S, Shyy JY, Chien S. Interplay between integrins and FLK-1 in shear stress-induced signaling. Am J Physiol Cell Physiol. 2002 Nov; 283(5):C1540-7. PMID: 12372815.
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      80. Miao H, Li S, Hu YL, Yuan S, Zhao Y, Chen BP, Puzon-McLaughlin W, Tarui T, Shyy JY, Takada Y, Usami S, Chien S. Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci. 2002 May 15; 115(Pt 10):2199-206. PMID: 11973360.
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      81. Miao H, Yuan S, Wang Y, Tsygankov A, Chien S. Role of Cbl in shear-activation of PI 3-kinase and JNK in endothelial cells. Biochem Biophys Res Commun. 2002 Apr 12; 292(4):892-9. PMID: 11944898.
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      82. Li S, Butler P, Wang Y, Hu Y, Han DC, Usami S, Guan JL, Chien S. The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3546-51. PMID: 11891289; PMCID: PMC122560.
      83. Liu Y, Chen BP, Lu M, Zhu Y, Stemerman MB, Chien S, Shyy JY. Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):76-81. PMID: 11788464.
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