|School||University of California, San Diego|
|Address||9500 Gilman Drive #0063|
CA La Jolla 92093
|Fellowship|| McMaster University ||1988|
|Residency||McMaster University ||1986|
|BSc||University of Toronto (Trinity College)||1979|
My research program explores the interaction of luminal contents including microbes with the gastrointestinal mucosa that can lead to inflammatory disease and associated epithelial cancer. I have focused on the role of oxidative stress in modulating host responses to bacteria, antigens and inflammatory processes and examining the multi-functional regulatory protein, AP endonuclease-1 as it regulates epithelial cell responses. Our general approach has been to study signaling events in cultured cell lines and to validate the models using human tissues. As a clinician-scientist, gastroenterologist, I have been active in basic, translational, and clinical research.
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