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    Seth Cohen

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentChemistry and Biochemistry
    Address9500 Gilman Drive #0358
    CA La Jolla 92093
    Phone858-822-5596
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Developing Metallo-Beta-Lactamase Inhibitors
      NIH/NIGMS R01GM111926Apr 1, 2015 - Jan 31, 2019
      Role: Principal Investigator
      Role of CSN in the activity and dynamic cycling of cullin-RING ubiquitin ligases
      NIH/NCI R01CA164803Jan 1, 2013 - Dec 31, 2017
      Role: Principal Investigator
      Insight and Optimization of Metalloprotein Inhibitors
      NIH/NIGMS R01GM098435Sep 1, 2011 - May 31, 2019
      Role: Principal Investigator
      New Strategies and Screening Methods for Metalloproteinase Inhibition
      NIH/NHLBI R21HL094571Aug 1, 2009 - May 31, 2012
      Role: Principal Investigator
      A Bioinorganic Approach to Anthrax Lethal Factor Inhibitors
      NIH/NIAID R03AI070651Apr 1, 2007 - Mar 31, 2010
      Role: Principal Investigator
      Translational Development of Novel MMP Inhibitors
      NIH/NHLBI R01HL080049Jan 1, 2006 - Jun 30, 2011
      Role: Principal Investigator
      INVESTIGATING CIS PLATIN INTERACTIONS WITH TELOMERE DNA
      NIH/NCI F32CA083330Sep 30, 1999
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Schukraft GEM, Ayala S, Dick BL, Cohen S. Isoreticular expansion of polyMOFs achieves high surface area materials. Chem Commun (Camb). 2017 Sep 15. PMID: 28913536.
        View in: PubMed
      2. Chen AY, Thomas PW, Stewart AC, Bergstrom A, Cheng Z, Miller C, Bethel CR, Marshall SH, Credille CV, Riley CL, Page RC, Bonomo RA, Crowder MW, Tierney DL, Fast W, Cohen S. Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-ß-lactamase-1. J Med Chem. 2017 Aug 30. PMID: 28809565.
        View in: PubMed
      3. Cohen S. A Bioinorganic Approach to Fragment-Based Drug Discovery Targeting Metalloenzymes. Acc Chem Res. 2017 Aug 15; 50(8):2007-2016. PMID: 28715203.
        View in: PubMed
      4. Dick BL, Patel A, McCammon JA, Cohen S. Effect of donor atom identity on metal-binding pharmacophore coordination. J Biol Inorg Chem. 2017 Jun; 22(4):605-613. PMID: 28389830.
        View in: PubMed
      5. Perez C, Li J, Parlati F, Rouffet M, Ma Y, Zhou HJ, Mackinnon AL, Chou TF, Deshaies RJ, Cohen S. Correction to Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J Med Chem. 2017 Apr 13; 60(7):3217. PMID: 28328205.
        View in: PubMed
      6. Ayala S, Zhang Z, Cohen S. Hierarchical structure and porosity in UiO-66 polyMOFs. Chem Commun (Camb). 2017 Mar 09; 53(21):3058-3061. PMID: 28240327.
        View in: PubMed
      7. Li J, Yakushi T, Parlati F, Mackinnon AL, Perez C, Ma Y, Carter KP, Colayco S, Magnuson G, Brown B, Nguyen K, Vasile S, Suyama E, Smith LH, Sergienko E, Pinkerton AB, Chung TDY, Palmer AE, Pass I, Hess S, Cohen S, Deshaies RJ. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017 May; 13(5):486-493. PMID: 28244987.
        View in: PubMed
      8. Perez C, Li J, Parlati F, Rouffet M, Ma Y, Mackinnon AL, Chou TF, Deshaies RJ, Cohen S. Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J Med Chem. 2017 Feb 13. PMID: 28191850.
        View in: PubMed
      9. Cohen S. The Postsynthetic Renaissance in Porous Solids. J Am Chem Soc. 2017 Feb 10. PMID: 28118009.
        View in: PubMed
      10. Chen Y, Lai B, Zhang Z, Cohen S. The effect of metalloprotein inhibitors on cellular metal ion content and distribution. Metallomics. 2017 Feb 07. PMID: 28168254.
        View in: PubMed
      11. Li J, Yu X, Xu M, Liu W, Sandraz E, Lan H, Wang J, Cohen S. Metal-Organic Frameworks as Micromotors with Tunable Engines and Brakes. J Am Chem Soc. 2016 Dec 19. PMID: 27992201.
        View in: PubMed
      12. Moreton JC, Denny MS, Cohen S. High MOF loading in mixed-matrix membranes utilizing styrene/butadiene copolymers. Chem Commun (Camb). 2016 Nov 25. PMID: 27886285.
        View in: PubMed
      13. Yu X, Cohen S. Photocatalytic Metal-Organic Frameworks for Selective 2,2,2-Trifluoroethylation of Styrenes. J Am Chem Soc. 2016 Sep 28; 138(38):12320-3. PMID: 27617480.
        View in: PubMed
      14. Chen TH, Wang L, Trueblood JV, Grassian VH, Cohen S. Poly(isophthalic acid)(ethylene oxide) as a Macromolecular Modulator for Metal-Organic Polyhedra. J Am Chem Soc. 2016 Aug 3; 138(30):9646-54. PMID: 27400759.
        View in: PubMed
      15. Zhang X, Zhang Z, Boissonnault J, Cohen S. Design and synthesis of squaramide-based MOFs as efficient MOF-supported hydrogen-bonding organocatalysts. Chem Commun (Camb). 2016 Jun 30; 52(55):8585-8. PMID: 27320848.
        View in: PubMed
      16. Credille CV, Chen Y, Cohen S. Fragment-Based Identification of Influenza Endonuclease Inhibitors. J Med Chem. 2016 Jul 14; 59(13):6444-54. PMID: 27291165.
        View in: PubMed
      17. Cohen S, Zhang Z, Boissonnault JA. Toward "metalloMOFzymes": Metal-Organic Frameworks with Single-Site Metal Catalysts for Small-Molecule Transformations. Inorg Chem. 2016 Aug 1; 55(15):7281-90. PMID: 27231968.
        View in: PubMed
      18. Daniel KB, Callmann CE, Gianneschi NC, Cohen S. Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species. Chem Commun (Camb). 2016 Jan 26; 52(10):2126-8. PMID: 26696280.
        View in: PubMed
      19. Chen TH, Schneemann A, Fischer RA, Cohen S. Metal-organic frameworks constructed from crown ether-based 1,4-benzenedicarboxylic acid derivatives. Dalton Trans. 2016 Feb 21; 45(7):3063-9. PMID: 26765588.
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      20. DeCoste JB, Denny MS, Peterson GW, Mahle JJ, Cohen S. Enhanced aging properties of HKUST-1 in hydrophobic mixed-matrix membranes for ammonia adsorption. Chem Sci. 2016 Apr 21; 7(4):2711-2716. PMID: 28660045.
        View in: PubMed
      21. Zhang Z, Nguyen HT, Miller SA, Ploskonka AM, DeCoste JB, Cohen S. Polymer-Metal-Organic Frameworks (polyMOFs) as Water Tolerant Materials for Selective Carbon Dioxide Separations. J Am Chem Soc. 2016 Jan 27; 138(3):920-5. PMID: 26709448.
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      22. Lee Y, Kim S, Fei H, Kang JK, Cohen S. Photocatalytic CO2 reduction using visible light by metal-monocatecholato species in a metal-organic framework. Chem Commun (Camb). 2015 Nov 5; 51(92):16549-52. PMID: 26421325.
        View in: PubMed
      23. Chen Y, Cohen S. Investigating the Selectivity of Metalloenzyme Inhibitors in the Presence of Competing Metalloproteins. ChemMedChem. 2015 Oct; 10(10):1733-8. PMID: 26412596.
        View in: PubMed
      24. Taddei M, Dau PV, Cohen S, Ranocchiari M, van Bokhoven JA, Costantino F, Sabatini S, Vivani R. Efficient microwave assisted synthesis of metal-organic framework UiO-66: optimization and scale up. Dalton Trans. 2015 Jul 28; 44(31):14019-26. PMID: 26165508.
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      25. Fei H, Sampson MD, Lee Y, Kubiak CP, Cohen S. Photocatalytic CO2 Reduction to Formate Using a Mn(I) Molecular Catalyst in a Robust Metal-Organic Framework. Inorg Chem. 2015 Jul 20; 54(14):6821-8. PMID: 26135673.
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      26. Denny MS, Cohen S. In Situ Modification of Metal-Organic Frameworks in Mixed-Matrix Membranes. Angew Chem Int Ed Engl. 2015 Jul 27; 54(31):9029-32. PMID: 26073065.
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      27. Patterson JP, Abellan P, Denny MS, Park C, Browning ND, Cohen S, Evans JE, Gianneschi NC. Observing the Growth of Metal-Organic Frameworks by in Situ Liquid Cell Transmission Electron Microscopy. J Am Chem Soc. 2015 Jun 17; 137(23):7322-8. PMID: 26053504.
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      28. Yu X, Cohen S. Photocatalytic metal-organic frameworks for the aerobic oxidation of arylboronic acids. Chem Commun (Camb). 2015 Jun 2; 51(48):9880-3. PMID: 25994944.
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      29. Daniel KB, Sullivan ED, Chen Y, Chan JC, Jennings PA, Fierke CA, Cohen S. Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release. J Med Chem. 2015 Jun 11; 58(11):4812-21. PMID: 25974739.
        View in: PubMed
      30. Zhang Z, Nguyen HT, Miller SA, Cohen S. polyMOFs: A Class of Interconvertible Polymer-Metal-Organic-Framework Hybrid Materials. Angew Chem Int Ed Engl. 2015 May 18; 54(21):6152-7. PMID: 25926022.
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      31. Perez C, Monserrat JP, Chen Y, Cohen S. Exploring hydrogen peroxide responsive thiazolidinone-based prodrugs. Chem Commun (Camb). 2015 Apr 9; 51(33):7116-9. PMID: 25811298.
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      32. Dau PV, Cohen S. A bifunctional, site-isolated metal-organic framework-based tandem catalyst. Inorg Chem. 2015 Apr 6; 54(7):3134-8. PMID: 25785543.
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      33. Lee Y, Kim S, Kang JK, Cohen S. Photocatalytic CO2 reduction by a mixed metal (Zr/Ti), mixed ligand metal-organic framework under visible light irradiation. Chem Commun (Camb). 2015 Mar 17; 51(26):5735-8. PMID: 25719864.
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      34. Fei H, Cohen S. Metalation of a Thiocatechol-Functionalized Zr(IV)-Based Metal-Organic Framework for Selective C-H Functionalization. J Am Chem Soc. 2015 Feb 18; 137(6):2191-4. PMID: 25650584.
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      35. Nishida J, Tamimi A, Fei H, Pullen S, Ott S, Cohen S, Fayer MD. Structural dynamics inside a functionalized metal-organic framework probed by ultrafast 2D IR spectroscopy. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18442-7. PMID: 25512539.
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      36. Fei H, Pullen S, Wagner A, Ott S, Cohen S. Functionalization of robust Zr(iv)-based metal-organic framework films via a postsynthetic ligand exchange. Chem Commun (Camb). 2014 Dec 2; 51(1):66-9. PMID: 25364799.
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      37. Dau PV, Cohen S. Modulating H2 sorption in metal-organic frameworks via ordered functional groups. Chem Commun (Camb). 2014 Sep 16; 50(81):12154-7. PMID: 25177758.
        View in: PubMed
      38. Martin DP, Blachly PG, McCammon JA, Cohen S. Exploring the influence of the protein environment on metal-binding pharmacophores. J Med Chem. 2014 Aug 28; 57(16):7126-35. PMID: 25116076.
        View in: PubMed
      39. Cohen S. Editorial: translating bioinorganic chemistry. ChemMedChem. 2014 Jun; 9(6):1087-9. PMID: 24864024.
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      40. Taddei M, Costantino F, Vivani R, Sabatini S, Lim SH, Cohen S. The use of a rigid tritopic phosphonic ligand for the synthesis of a robust honeycomb-like layered zirconium phosphonate framework. Chem Commun (Camb). 2014 Jun 1; 50(43):5737-40. PMID: 24752395.
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      41. Fei H, Cohen S. A robust, catalytic metal-organic framework with open 2,2'-bipyridine sites. Chem Commun (Camb). 2014 Apr 10; 50(37):4810-2. PMID: 24687158.
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      42. Martin DP, Blachly PG, Marts AR, Woodruff TM, de Oliveira CA, McCammon JA, Tierney DL, Cohen S. 'Unconventional' coordination chemistry by metal chelating fragments in a metalloprotein active site. J Am Chem Soc. 2014 Apr 9; 136(14):5400-6. PMID: 24635441.
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      43. Fei H, Shin J, Meng YS, Adelhardt M, Sutter J, Meyer K, Cohen S. Reusable oxidation catalysis using metal-monocatecholato species in a robust metal-organic framework. J Am Chem Soc. 2014 Apr 2; 136(13):4965-73. PMID: 24597832.
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      44. Pullen S, Fei H, Orthaber A, Cohen S, Ott S. Enhanced photochemical hydrogen production by a molecular diiron catalyst incorporated into a metal-organic framework. J Am Chem Soc. 2013 Nov 13; 135(45):16997-7003. PMID: 24116734.
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      45. Day JA, Cohen S. Investigating the selectivity of metalloenzyme inhibitors. J Med Chem. 2013 Oct 24; 56(20):7997-8007. PMID: 24074025.
        View in: PubMed
      46. Perez C, Daniel KB, Cohen S. Evaluating prodrug strategies for esterase-triggered release of alcohols. ChemMedChem. 2013 Oct; 8(10):1662-7. PMID: 23929690.
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      47. Dau PV, Cohen S. Cyclometalated metal-organic frameworks as stable and reusable heterogeneous catalysts for allylic N-alkylation of amines. Chem Commun (Camb). 2013 Jul 14; 49(55):6128-30. PMID: 23732325.
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      48. Barrios AM, Cohen S, Lim MH. Medicinal inorganic chemistry: a web themed issue. Chem Commun (Camb). 2013 Jul 7; 49(53):5910-1. PMID: 23715532.
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      49. Garner AL, Fullagar JL, Day JA, Cohen S, Janda KD. Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors. J Am Chem Soc. 2013 Jul 10; 135(27):10014-7. PMID: 23808771.
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      50. Lim SH, Cohen S. Self-assembled supramolecular clusters based on phosphines and coinage metals: tetrahedra, helicates, and mesocates. Inorg Chem. 2013 Jul 15; 52(14):7862-72. PMID: 23799780.
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      51. Martin DP, Hann ZS, Cohen S. Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site. Inorg Chem. 2013 Nov 4; 52(21):12207-15. PMID: 23706138.
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      52. Fei H, Cahill JF, Prather KA, Cohen S. Tandem postsynthetic metal ion and ligand exchange in zeolitic imidazolate frameworks. Inorg Chem. 2013 Apr 1; 52(7):4011-6. PMID: 23516974.
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      53. Allen CA, Boissonnault JA, Cirera J, Gulland R, Paesani F, Cohen S. Chemically crosslinked isoreticular metal-organic frameworks. Chem Commun (Camb). 2013 Apr 21; 49(31):3200-2. PMID: 23486829.
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      54. Fullagar JL, Garner AL, Struss AK, Day JA, Martin DP, Yu J, Cai X, Janda KD, Cohen S. Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase. Chem Commun (Camb). 2013 Apr 21; 49(31):3197-9. PMID: 23482955.
        View in: PubMed
      55. Daniel KB, Agrawal A, Manchester M, Cohen S. Readily accessible fluorescent probes for sensitive biological imaging of hydrogen peroxide. Chembiochem. 2013 Mar 18; 14(5):593-8. PMID: 23436442.
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      56. Dau PV, Polanco LR, Cohen S. Dioxole functionalized metal-organic frameworks. Dalton Trans. 2013 Mar 21; 42(11):4013-8. PMID: 23340964.
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      57. Taddei M, Costantino F, Ienco A, Comotti A, Dau PV, Cohen S. Synthesis, breathing, and gas sorption study of the first isoreticular mixed-linker phosphonate based metal-organic frameworks. Chem Commun (Camb). 2013 Feb 14; 49(13):1315-7. PMID: 23303192.
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      58. Cmarik GE, Kim M, Cohen S, Walton KS. Tuning the adsorption properties of UiO-66 via ligand functionalization. Langmuir. 2012 Nov 6; 28(44):15606-13. PMID: 23057691.
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      59. Kim M, Cahill JF, Fei H, Prather KA, Cohen S. Postsynthetic ligand and cation exchange in robust metal-organic frameworks. J Am Chem Soc. 2012 Oct 31; 134(43):18082-8. PMID: 23039827.
        View in: PubMed
      60. Dau PV, Tanabe KK, Cohen S. Functional group effects on metal-organic framework topology. Chem Commun (Camb). 2012 Sep 28; 48(75):9370-2. PMID: 22895350.
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      61. Garner AL, Struss AK, Fullagar JL, Agrawal A, Moreno AY, Cohen S, Janda KD. 3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. ACS Med Chem Lett. 2012 Aug 9; 3(8):668-672. PMID: 23181168.
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      62. Dau PV, Kim M, Garibay SJ, Münch FH, Moore CE, Cohen S. Single-atom ligand changes affect breathing in an extended metal-organic framework. Inorg Chem. 2012 May 21; 51(10):5671-6. PMID: 22545717.
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      63. Martin DP, Cohen S. Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors. Chem Commun (Camb). 2012 May 28; 48(43):5259-61. PMID: 22531842.
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      64. Kim M, Boissonnault JA, Allen CA, Dau PV, Cohen S. Functional tolerance in an isoreticular series of highly porous metal-organic frameworks. Dalton Trans. 2012 May 28; 41(20):6277-82. PMID: 22491705.
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      65. Lim SH, Su Y, Cohen S. Supramolecular tetrahedra of phosphines and coinage metals. Angew Chem Int Ed Engl. 2012 May 21; 51(21):5106-9. PMID: 22488749.
        View in: PubMed
      66. Tanakit A, Rouffet M, Martin DP, Cohen S. Investigating chelating sulfonamides and their use in metalloproteinase inhibitors. Dalton Trans. 2012 Jun 7; 41(21):6507-15. PMID: 22411188.
        View in: PubMed
      67. Kim M, Boissonnault JA, Dau PV, Cohen S. Metal-organic framework regioisomers based on bifunctional ligands. Angew Chem Int Ed Engl. 2011 Dec 16; 50(51):12193-6. PMID: 22025409.
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      68. Chen C, Allen CA, Cohen S. Tandem postsynthetic modification of metal-organic frameworks using an inverse-electron-demand Diels-Alder reaction. Inorg Chem. 2011 Nov 7; 50(21):10534-6. PMID: 21985297.
        View in: PubMed
      69. Cohen S. Postsynthetic methods for the functionalization of metal-organic frameworks. Chem Rev. 2012 Feb 8; 112(2):970-1000. PMID: 21916418.
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      70. Jourden JL, Daniel KB, Cohen S. Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors. Chem Commun (Camb). 2011 Jul 28; 47(28):7968-70. PMID: 21677985.
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      71. Kim M, Cahill JF, Prather KA, Cohen S. Postsynthetic modification at orthogonal reactive sites on mixed, bifunctional metal-organic frameworks. Chem Commun (Camb). 2011 Jul 21; 47(27):7629-31. PMID: 21660333.
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      72. Rouffet M, Cohen S. Emerging trends in metalloprotein inhibition. Dalton Trans. 2011 Apr 14; 40(14):3445-54. PMID: 21290034.
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      73. Kim M, Garibay SJ, Cohen S. Microwave-assisted cyanation of an aryl bromide directly on a metal-organic framework. Inorg Chem. 2011 Feb 7; 50(3):729-31. PMID: 21207935.
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      74. Jacobsen JA, Fullagar JL, Miller MT, Cohen S. Identifying chelators for metalloprotein inhibitors using a fragment-based approach. J Med Chem. 2011 Jan 27; 54(2):591-602. PMID: 21189019.
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      75. Tanabe KK, Allen CA, Cohen S. Photochemical activation of a metal-organic framework to reveal functionality. Angew Chem Int Ed Engl. 2010 Dec 10; 49(50):9730-3. PMID: 21064064.
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      76. Tanabe KK, Cohen S. Postsynthetic modification of metal-organic frameworks--a progress report. Chem Soc Rev. 2011 Feb; 40(2):498-519. PMID: 21103601.
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      77. Daniel KB, Major Jourden JL, Negoescu KE, Cohen S. Activation of sulfonate ester based matrix metalloproteinase proinhibitors by hydrogen peroxide. J Biol Inorg Chem. 2011 Feb; 16(2):313-23. PMID: 21049301.
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      78. Martin D, Rouffet M, Cohen S. Illuminating metal-ion sensors: benzimidazolesulfonamide metal complexes. Inorg Chem. 2010 Nov 15; 49(22):10226-8. PMID: 20942382.
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      79. Garibay SJ, Cohen S. Isoreticular synthesis and modification of frameworks with the UiO-66 topology. Chem Commun (Camb). 2010 Nov 7; 46(41):7700-2. PMID: 20871917.
        View in: PubMed
      80. Major Jourden JL, Cohen S. Hydrogen peroxide activated matrix metalloproteinase inhibitors: a prodrug approach. Angew Chem Int Ed Engl. 2010 Sep 10; 49(38):6795-7. PMID: 20715043.
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      81. Garibay SJ, Wang Z, Cohen S. Evaluation of heterogeneous metal-organic framework organocatalysts prepared by postsynthetic modification. Inorg Chem. 2010 Sep 6; 49(17):8086-91. PMID: 20698561.
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      82. Schulze Wischeler J, Innocenti A, Vullo D, Agrawal A, Cohen S, Heine A, Supuran CT, Klebe G. Bidentate Zinc chelators for alpha-carbonic anhydrases that produce a trigonal bipyramidal coordination geometry. ChemMedChem. 2010 Sep 3; 5(9):1609-15. PMID: 20629007.
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      83. Tanabe KK, Cohen S. Modular, active, and robust Lewis acid catalysts supported on a metal-organic framework. Inorg Chem. 2010 Jul 19; 49(14):6766-74. PMID: 20565054.
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      84. Rouffet M, de Oliveira CA, Udi Y, Agrawal A, Sagi I, McCammon JA, Cohen S. From sensors to silencers: quinoline- and benzimidazole-sulfonamides as inhibitors for zinc proteases. J Am Chem Soc. 2010 Jun 23; 132(24):8232-3. PMID: 20507095.
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      85. Volkringer C, Cohen S. Generating reactive MILs: isocyanate- and isothiocyanate-bearing MILs through postsynthetic modification. Angew Chem Int Ed Engl. 2010 Jun 21; 49(27):4644-8. PMID: 20480478.
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      86. Nguyen JG, Cohen S. Moisture-resistant and superhydrophobic metal-organic frameworks obtained via postsynthetic modification. J Am Chem Soc. 2010 Apr 7; 132(13):4560-1. PMID: 20232871.
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      87. Agrawal A, Johnson SL, Jacobsen JA, Miller MT, Chen LH, Pellecchia M, Cohen S. Chelator fragment libraries for targeting metalloproteinases. ChemMedChem. 2010 Feb 1; 5(2):195-9. PMID: 20058293.
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      88. Major Jourden JL, Cohen S. Enzymatic activation of a matrix metalloproteinase inhibitor. Chem Commun (Camb). 2010 Feb 28; 46(8):1241-3. PMID: 20449263.
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      89. Wang Z, Tanabe KK, Cohen S. Tuning hydrogen sorption properties of metal-organic frameworks by postsynthetic covalent modification. Chemistry. 2010 Jan 4; 16(1):212-7. PMID: 19918824.
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      90. Jacobsen JA, Stork JR, Magde D, Cohen S. Hydrogen-bond rigidified BODIPY dyes. Dalton Trans. 2010 Jan 21; 39(3):957-62. PMID: 20066240.
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      91. Wang Z, Cohen S. Modulating metal-organic frameworks to breathe: a postsynthetic covalent modification approach. J Am Chem Soc. 2009 Nov 25; 131(46):16675-7. PMID: 19886623.
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      92. Jacobsen JA, Major Jourden JL, Miller MT, Cohen S. To bind zinc or not to bind zinc: an examination of innovative approaches to improved metalloproteinase inhibition. Biochim Biophys Acta. 2010 Jan; 1803(1):72-94. PMID: 19712708.
        View in: PubMed
      93. Garibay SJ, Wang Z, Tanabe KK, Cohen S. Postsynthetic modification: a versatile approach toward multifunctional metal-organic frameworks. Inorg Chem. 2009 Aug 3; 48(15):7341-9. PMID: 19580256.
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      94. Agrawal A, de Oliveira CA, Cheng Y, Jacobsen JA, McCammon JA, Cohen S. Thioamide hydroxypyrothiones supersede amide hydroxypyrothiones in potency against anthrax lethal factor. J Med Chem. 2009 Feb 26; 52(4):1063-74. PMID: 19170530.
        View in: PubMed
      95. Yan YL, Miller MT, Cao Y, Cohen S. Synthesis of hydroxypyrone- and hydroxythiopyrone-based matrix metalloproteinase inhibitors: developing a structure-activity relationship. Bioorg Med Chem Lett. 2009 Apr 1; 19(7):1970-6. PMID: 19261472.
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      96. Wang Z, Cohen S. Postsynthetic modification of metal-organic frameworks. Chem Soc Rev. 2009 May; 38(5):1315-29. PMID: 19384440.
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      97. Wang Z, Tanabe KK, Cohen S. Accessing postsynthetic modification in a series of metal-organic frameworks and the influence of framework topology on reactivity. Inorg Chem. 2009 Jan 5; 48(1):296-306. PMID: 19053339.
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      98. Tanabe KK, Cohen S. Engineering a metal-organic framework catalyst by using postsynthetic modification. Angew Chem Int Ed Engl. 2009; 48(40):7424-7. PMID: 19725088.
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      99. Thoi VS, Stork JR, Niles ET, Depperman EC, Tierney DL, Cohen S. Diamidodipyrrins: versatile bipyrrolic ligands with multiple metal binding modes. Inorg Chem. 2008 Nov 17; 47(22):10533-41. PMID: 18939825.
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      100. Jacobsen FE, Buczynski MW, Dennis EA, Cohen S. A macrophage cell model for selective metalloproteinase inhibitor design. Chembiochem. 2008 Sep 1; 9(13):2087-95. PMID: 18666306.
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      101. Tanabe KK, Wang Z, Cohen S. Systematic functionalization of a metal-organic framework via a postsynthetic modification approach. J Am Chem Soc. 2008 Jul 2; 130(26):8508-17. PMID: 18540671.
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      102. Dugan E, Wang Z, Okamura M, Medina A, Cohen S. Covalent modification of a metal-organic framework with isocyanates: probing substrate scope and reactivity. Chem Commun (Camb). 2008 Aug 7; (29):3366-8. PMID: 18633491.
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      103. Agrawal A, Romero-Perez D, Jacobsen JA, Villarreal FJ, Cohen S. Zinc-binding groups modulate selective inhibition of MMPs. ChemMedChem. 2008 May; 3(5):812-20. PMID: 18181119.
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      104. Wang Z, Cohen S. Tandem modification of metal-organic frameworks by a postsynthetic approach. Angew Chem Int Ed Engl. 2008; 47(25):4699-702. PMID: 18442157.
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      105. Garibay SJ, Stork JR, Wang Z, Cohen S, Telfer SG. Enantiopure vs. racemic metalloligands: impact on metal-organic framework structure and synthesis. Chem Commun (Camb). 2007 Dec 14; (46):4881-3. PMID: 18361356.
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      106. Stork JR, Thoi VS, Cohen S. Rare examples of transition-metal-main-group metal heterometallic metal-organic frameworks from gallium and indium dipyrrinato complexes and silver salts: synthesis and framework variability. Inorg Chem. 2007 Dec 24; 46(26):11213-23. PMID: 18047326.
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      113. Thoi VS, Stork JR, Magde D, Cohen S. Luminescent dipyrrinato complexes of trivalent group 13 metal ions. Inorg Chem. 2006 Dec 25; 45(26):10688-97. PMID: 17173424.
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      115. Golynskiy MV, Gunderson WA, Hendrich MP, Cohen S. Metal binding studies and EPR spectroscopy of the manganese transport regulator MntR. Biochemistry. 2006 Dec 26; 45(51):15359-72. PMID: 17176058.
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      116. Jacobsen FE, Breece RM, Myers WK, Tierney DL, Cohen S. Model complexes of cobalt-substituted matrix metalloproteinases: tools for inhibitor design. Inorg Chem. 2006 Sep 4; 45(18):7306-15. PMID: 16933932.
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      117. Lewis JA, Mongan J, McCammon JA, Cohen S. Evaluation and binding-mode prediction of thiopyrone-based inhibitors of anthrax lethal factor. ChemMedChem. 2006 Jul; 1(7):694-7. PMID: 16902919.
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      118. Jacobsen FE, Lewis JA, Cohen S. A new role for old ligands: discerning chelators for zinc metalloproteinases. J Am Chem Soc. 2006 Mar 15; 128(10):3156-7. PMID: 16522091.
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      119. Puerta DT, Botta M, Jocher CJ, Werner EJ, Avedano S, Raymond KN, Cohen S. Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA. J Am Chem Soc. 2006 Feb 22; 128(7):2222-3. PMID: 16478170.
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      120. Puerta DT, Griffin MO, Lewis JA, Romero-Perez D, Garcia R, Villarreal FJ, Cohen S. Heterocyclic zinc-binding groups for use in next-generation matrix metalloproteinase inhibitors: potency, toxicity, and reactivity. J Biol Inorg Chem. 2006 Mar; 11(2):131-8. PMID: 16391944.
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      121. Brayton D, Jacobsen FE, Cohen S, Farmer PJ. A novel heterocyclic atom exchange reaction with Lawesson's reagent: a one-pot synthesis of dithiomaltol. Chem Commun (Camb). 2006 Jan 14; (2):206-8. PMID: 16372107.
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      122. Tran BL, Cohen S. Flavothionato metal complexes: implications for the use of hydroxyflavothiones as green pesticides. Chem Commun (Camb). 2006 Jan 14; (2):203-5. PMID: 16372106.
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      123. Puerta DT, Mongan J, Tran BL, McCammon JA, Cohen S. Potent, selective pyrone-based inhibitors of stromelysin-1. J Am Chem Soc. 2005 Oct 19; 127(41):14148-9. PMID: 16218585.
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      124. He H, Puerta DT, Cohen S, Rodgers KR. Structural and spectroscopic study of reactions between chelating zinc-binding groups and mimics of the matrix metalloproteinase and disintegrin metalloprotease catalytic sites: the coordination chemistry of metalloprotease inhibition. Inorg Chem. 2005 Oct 17; 44(21):7431-42. PMID: 16212369.
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      125. Murphy DL, Malachowski MR, Campana CF, Cohen S. A chiral, heterometallic metal-organic framework derived from a tris(chelate) coordination complex. Chem Commun (Camb). 2005 Nov 28; (44):5506-8. PMID: 16358044.
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      126. Lewis JA, Tran BL, Puerta DT, Rumberger EM, Hendrickson DN, Cohen S. Synthesis, structure and spectroscopy of new thiopyrone and hydroxypyridinethione transition-metal complexes. Dalton Trans. 2005 Aug 7; (15):2588-96. PMID: 16025179.
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      127. Halper SR, Cohen S. Self-assembly of heteroleptic [Cu(dipyrrinato)(hfacac)] complexes directed by fluorine-fluorine interactions. Inorg Chem. 2005 Jun 13; 44(12):4139-41. PMID: 15934739.
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      128. Golynskiy MV, Davis TC, Helmann JD, Cohen S. Metal-induced structural organization and stabilization of the metalloregulatory protein MntR. Biochemistry. 2005 Mar 8; 44(9):3380-9. PMID: 15736948.
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      129. Halper SR, Cohen S. Heterometallic metal-organic frameworks based on tris(dipyrrinato) coordination complexes. Inorg Chem. 2005 Feb 7; 44(3):486-8. PMID: 15679375.
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      130. Lewis JA, Cohen S. Addressing lead toxicity: complexation of lead(II) with thiopyrone and hydroxypyridinethione O,S mixed chelators. Inorg Chem. 2004 Oct 18; 43(21):6534-6. PMID: 15476346.
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      131. Do L, Halper SR, Cohen S. Helical coordination polymers and cyclic dimers formed from heteroleptic thioether-dipyrrinato copper(II) complexes. Chem Commun (Camb). 2004 Dec 7; (23):2662-3. PMID: 15568056.
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      132. Puerta DT, Lewis JA, Cohen S. New beginnings for matrix metalloproteinase inhibitors: identification of high-affinity zinc-binding groups. J Am Chem Soc. 2004 Jul 14; 126(27):8388-9. PMID: 15237990.
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      133. Jacobsen FE, Cohen S. Using model complexes to augment and advance metalloproteinase inhibitor design. Inorg Chem. 2004 May 17; 43(10):3038-47. PMID: 15132609.
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      134. Halper SR, Malachowski MR, Delaney HM, Cohen S. Heteroleptic copper dipyrromethene complexes: synthesis, structure, and coordination polymers. Inorg Chem. 2004 Feb 23; 43(4):1242-9. PMID: 14966958.
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      135. Lewis JA, Puerta DT, Cohen S. Metal complexes of the trans-influencing ligand thiomaltol. Inorg Chem. 2003 Nov 17; 42(23):7455-9. PMID: 14606841.
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      136. Lieser SA, Davis TC, Helmann JD, Cohen S. DNA-binding and oligomerization studies of the manganese(II) metalloregulatory protein MntR from Bacillus subtilis. Biochemistry. 2003 Nov 4; 42(43):12634-42. PMID: 14580210.
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      137. Halper SR, Cohen S. Synthesis, structure, and spectroscopy of phenylacetylenylene rods incorporating meso-substituted dipyrrin ligands. Chemistry. 2003 Oct 6; 9(19):4661-9. PMID: 14566871.
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      138. Puerta DT, Cohen S. Synthesis and structure of the hexameric, dodecanuclear metallamacrocycle [(5-methyl-3-phenylpyrazole)2Zn2(OCH2CH2S)]6. Chem Commun (Camb). 2003 Jun 7; (11):1278-9. PMID: 12809229.
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      139. Puerta DT, Cohen S. Examination of novel zinc-binding groups for use in matrix metalloproteinase inhibitors. Inorg Chem. 2003 Jun 2; 42(11):3423-30. PMID: 12767177.
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      140. Puerta DT, Cohen S. Elucidating drug-metalloprotein interactions with tris(pyrazolyl)borate model complexes. Inorg Chem. 2002 Oct 7; 41(20):5075-82. PMID: 12354040.
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