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    Roger Tsien

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentChemistry and Biochemistry
    Address9500 Gilman Drive #0647
    CA La Jolla 92093
    Phone858-534-4891
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Rodriguez EA, Tran GN, Gross LA, Crisp JL, Shu X, Lin JY, Tsien RY. A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein. Nat Methods. 2016 Sep; 13(9):763-9. PMID: 27479328; NIHMSID: NIHMS800611 [Available on 03/01/17].
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      2. Ngo JT, Adams SR, Deerinck TJ, Boassa D, Rodriguez-Rivera F, Palida SF, Bertozzi CR, Ellisman MH, Tsien RY. Click-EM for imaging metabolically tagged nonprotein biomolecules. Nat Chem Biol. 2016 Jun; 12(6):459-65. PMID: 27110681.
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      3. Orosco RK, Savariar EN, Weissbrod PA, Diaz-Perez JA, Bouvet M, Tsien RY, Nguyen QT. Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model. J Surg Oncol. 2016 Feb; 113(2):138-43. PMID: 26799257.
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      4. Hua N, Baik F, Pham T, Phinikaridou A, Giordano N, Friedman B, Whitney M, Nguyen QT, Tsien RY, Hamilton JA. Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis. PLoS One. 2015; 10(10):e0139833. PMID: 26448434.
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      5. Malone CD, Olson ES, Mattrey RF, Jiang T, Tsien RY, Nguyen QT. Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent. PLoS One. 2015; 10(9):e0137104. PMID: 26336058.
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      6. Chung HK, Jacobs CL, Huo Y, Yang J, Krumm SA, Plemper RK, Tsien RY, Lin MZ. Tunable and reversible drug control of protein production via a self-excising degron. Nat Chem Biol. 2015 Sep; 11(9):713-20. PMID: 26214256.
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      7. Hussain T, Savariar EN, Diaz-Perez JA, Messer K, Pu M, Tsien RY, Nguyen QT. Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers. Head Neck. 2016 May; 38(5):715-23. PMID: 25521629.
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      8. Hussain T, Mastrodimos MB, Raju SC, Glasgow HL, Whitney M, Friedman B, Moore JD, Kleinfeld D, Steinbach P, Messer K, Pu M, Tsien RY, Nguyen QT. Fluorescently Labeled Peptide Increases Identification of Degenerated Facial Nerve Branches during Surgery and Improves Functional Outcome. PLoS One. 2015; 10(3):e0119600. PMID: 25751149.
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      9. Raju SC, Hauff SJ, Lemieux AJ, Orosco RK, Gross AM, Nguyen LT, Savariar E, Moss W, Whitney M, Cohen EE, Lippman SM, Tsien RY, Ideker T, Advani SJ, Nguyen QT. Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma. Oral Oncol. 2015 May; 51(5):470-5. PMID: 25735654.
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      10. Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy AM, Tsien RY, Advani SJ. Tumor radiosensitization by monomethyl auristatin e: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1; 75(7):1376-87. PMID: 25681274.
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      11. Woodford CR, Frady EP, Smith RS, Morey B, Canzi G, Palida SF, Araneda RC, Kristan WB, Kubiak CP, Miller EW, Tsien RY. Improved PeT Molecules for Optically Sensing Voltage in Neurons. J Am Chem Soc. 2015 Feb 11; 137(5):1817-24. PMID: 25584688.
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      12. Briggman KL, Kristan WB, González JE, Kleinfeld D, Tsien RY. Monitoring Integrated Activity of Individual Neurons Using FRET-Based Voltage-Sensitive Dyes. Adv Exp Med Biol. 2015; 859:149-69. PMID: 26238052.
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      13. Metildi CA, Felsen CN, Savariar EN, Nguyen QT, Kaushal S, Hoffman RM, Tsien RY, Bouvet M. Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models. Ann Surg Oncol. 2015 Jun; 22(6):2082-7. PMID: 25319581.
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      14. Hauff SJ, Raju SC, Orosco RK, Gross AM, Diaz-Perez JA, Savariar E, Nashi N, Hasselman J, Whitney M, Myers JN, Lippman SM, Tsien RY, Ideker T, Nguyen QT. Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice. Otolaryngol Head Neck Surg. 2014 Oct; 151(4):612-8. PMID: 25091190.
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      15. Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, Malinow R. Engineering a memory with LTD and LTP. Nature. 2014 Jul 17; 511(7509):348-52. PMID: 24896183.
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      16. Levin RA, Felsen CN, Yang J, Lin JY, Whitney MA, Nguyen QT, Tsien RY. An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation. PLoS One. 2014; 9(5):e97415. PMID: 24816650.
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      17. Crisp JL, Savariar EN, Glasgow HL, Ellies LG, Whitney MA, Tsien RY. Dual Targeting of Integrin avß3 and Matrix Metalloproteinase-2 for Optical Imaging of Tumors and Chemotherapeutic Delivery. Mol Cancer Ther. 2014 Jun; 13(6):1514-25. PMID: 24737028.
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      18. Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol. 2014 Feb; 75(2):303-8. PMID: 24740641.
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      19. Felsen CN, Savariar EN, Whitney M, Tsien RY. Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma. Am J Physiol Lung Cell Mol Physiol. 2014 Apr; 306(8):L764-74. PMID: 24508733.
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      20. Ortac I, Simberg D, Yeh YS, Yang J, Messmer B, Trogler WC, Tsien RY, Esener S. Dual-porosity hollow nanoparticles for the immunoprotection and delivery of nonhuman enzymes. Nano Lett. 2014 Jun 11; 14(6):3023-32. PMID: 24471767.
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      21. Weinstain R, Savariar EN, Felsen CN, Tsien RY. In vivo targeting of hydrogen peroxide by activatable cell-penetrating peptides. J Am Chem Soc. 2014 Jan 22; 136(3):874-7. PMID: 24377760.
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      22. Inagaki HK, Jung Y, Hoopfer ED, Wong AM, Mishra N, Lin JY, Tsien RY, Anderson DJ. Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship. Nat Methods. 2014 Mar; 11(3):325-32. PMID: 24363022.
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      23. Lin JY, Knutsen PM, Muller A, Kleinfeld D, Tsien RY. ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation. Nat Neurosci. 2013 Oct; 16(10):1499-508. PMID: 23995068.
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      24. Nguyen QT, Tsien RY. Fluorescence-guided surgery with live molecular navigation--a new cutting edge. Nat Rev Cancer. 2013 Sep; 13(9):653-62. PMID: 23924645.
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      25. Lin JY, Sann SB, Zhou K, Nabavi S, Proulx CD, Malinow R, Jin Y, Tsien RY. Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI). Neuron. 2013 Jul 24; 79(2):241-53. PMID: 23889931.
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      26. Tsien RY. Very long-term memories may be stored in the pattern of holes in the perineuronal net. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12456-61. PMID: 23832785.
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      27. Weinstain R, Kanter J, Friedman B, Ellies LG, Baker ME, Tsien RY. Fluorescent ligand for human progesterone receptor imaging in live cells. Bioconjug Chem. 2013 May 15; 24(5):766-71. PMID: 23600997.
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      28. Shani E, Weinstain R, Zhang Y, Castillejo C, Kaiserli E, Chory J, Tsien RY, Estelle M. Gibberellins accumulate in the elongating endodermal cells of Arabidopsis root. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4834-9. PMID: 23382232.
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      29. Butko MT, Savas JN, Friedman B, Delahunty C, Ebner F, Yates JR, Tsien RY. In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):E726-35. PMID: 23382246.
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      30. Orosco RK, Tsien RY, Nguyen QT. Fluorescence imaging in surgery. IEEE Rev Biomed Eng. 2013; 6:178-87. PMID: 23335674.
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      31. Savariar EN, Felsen CN, Nashi N, Jiang T, Ellies LG, Steinbach P, Tsien RY, Nguyen QT. Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides. Cancer Res. 2013 Jan 15; 73(2):855-64. PMID: 23188503.
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      32. Butko MT, Yang J, Geng Y, Kim HJ, Jeon NL, Shu X, Mackey MR, Ellisman MH, Tsien RY, Lin MZ. Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy. Nat Neurosci. 2012 Dec; 15(12):1742-51. PMID: 23103964.
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      33. Whitney M, Savariar EN, Friedman B, Levin RA, Crisp JL, Glasgow HL, Lefkowitz R, Adams SR, Steinbach P, Nashi N, Nguyen QT, Tsien RY. Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation. Angew Chem Int Ed Engl. 2013 Jan 2; 52(1):325-30. PMID: 23080482.
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      34. Ou HD, Kwiatkowski W, Deerinck TJ, Noske A, Blain KY, Land HS, Soria C, Powers CJ, May AP, Shu X, Tsien RY, Fitzpatrick JA, Long JA, Ellisman MH, Choe S, O'Shea CC. A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. Cell. 2012 Oct 12; 151(2):304-19. PMID: 23063122.
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      35. Lam AJ, St-Pierre F, Gong Y, Marshall JD, Cranfill PJ, Baird MA, McKeown MR, Wiedenmann J, Davidson MW, Schnitzer MJ, Tsien RY, Lin MZ. Improving FRET dynamic range with bright green and red fluorescent proteins. Nat Methods. 2012 Oct; 9(10):1005-12. PMID: 22961245.
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      36. Chen B, Friedman B, Whitney MA, Winkle JA, Lei IF, Olson ES, Cheng Q, Pereira B, Zhao L, Tsien RY, Lyden PD. Thrombin activity associated with neuronal damage during acute focal ischemia. J Neurosci. 2012 May 30; 32(22):7622-31. PMID: 22649241.
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      37. Olson ES, Whitney MA, Friedman B, Aguilera TA, Crisp JL, Baik FM, Jiang T, Baird SM, Tsimikas S, Tsien RY, Nguyen QT. In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. Integr Biol (Camb). 2012 Jun; 4(6):595-605. PMID: 22534729.
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      38. Qi YB, Garren EJ, Shu X, Tsien RY, Jin Y. Photo-inducible cell ablation in Caenorhabditis elegans using the genetically encoded singlet oxygen generating protein miniSOG. Proc Natl Acad Sci U S A. 2012 May 8; 109(19):7499-504. PMID: 22532663.
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      39. Miller EW, Lin JY, Frady EP, Steinbach PA, Kristan WB, Tsien RY. Optically monitoring voltage in neurons by photo-induced electron transfer through molecular wires. Proc Natl Acad Sci U S A. 2012 Feb 7; 109(6):2114-9. PMID: 22308458.
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      40. Shu X, Lev-Ram V, Deerinck TJ, Qi Y, Ramko EB, Davidson MW, Jin Y, Ellisman MH, Tsien RY. A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organisms. PLoS Biol. 2011 Apr; 9(4):e1001041. PMID: 21483721.
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      41. Wu AP, Whitney MA, Crisp JL, Friedman B, Tsien RY, Nguyen QT. Improved facial nerve identification with novel fluorescently labeled probe. Laryngoscope. 2011 Apr; 121(4):805-10. PMID: 21328585.
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      42. Whitney MA, Crisp JL, Nguyen LT, Friedman B, Gross LA, Steinbach P, Tsien RY, Nguyen QT. Fluorescent peptides highlight peripheral nerves during surgery in mice. Nat Biotechnol. 2011 Apr; 29(4):352-6. PMID: 21297616.
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      43. Ting R, Aguilera TA, Crisp JL, Hall DJ, Eckelman WC, Vera DR, Tsien RY. Fast 18F labeling of a near-infrared fluorophore enables positron emission tomography and optical imaging of sentinel lymph nodes. Bioconjug Chem. 2010 Oct 20; 21(10):1811-9. PMID: 20873712.
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      44. Hoffmann C, Gaietta G, Zürn A, Adams SR, Terrillon S, Ellisman MH, Tsien RY, Lohse MJ. Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nat Protoc. 2010 Sep; 5(10):1666-77. PMID: 20885379.
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      45. De Jaco A, Lin MZ, Dubi N, Comoletti D, Miller MT, Camp S, Ellisman M, Butko MT, Tsien RY, Taylor P. Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family. J Biol Chem. 2010 Sep 10; 285(37):28674-82. PMID: 20615874.
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      46. Whitney M, Crisp JL, Olson ES, Aguilera TA, Gross LA, Ellies LG, Tsien RY. Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides. J Biol Chem. 2010 Jul 16; 285(29):22532-41. PMID: 20460372.
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      47. Ouyang M, Huang H, Shaner NC, Remacle AG, Shiryaev SA, Strongin AY, Tsien RY, Wang Y. Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer. Cancer Res. 2010 Mar 15; 70(6):2204-12. PMID: 20197470.
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      48. Tsien RY. Nobel lecture: constructing and exploiting the fluorescent protein paintbox. Integr Biol (Camb). 2010 Mar; 2(2-3):77-93. PMID: 20473386.
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      49. Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY. Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4317-22. PMID: 20160097.
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      50. Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies LG, Scadeng M, Tsien RY. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4311-6. PMID: 20160077.
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      51. Tsien RY. The 2009 Lindau Nobel Laureate Meeting: Roger Y. Tsien, Chemistry 2008. J Vis Exp. 2010; (35). PMID: 20072108.
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      52. Dempsey GT, Bates M, Kowtoniuk WE, Liu DR, Tsien RY, Zhuang X. Photoswitching mechanism of cyanine dyes. J Am Chem Soc. 2009 Dec 30; 131(51):18192-3. PMID: 19961226.
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      53. Lin MZ, McKeown MR, Ng HL, Aguilera TA, Shaner NC, Campbell RE, Adams SR, Gross LA, Ma W, Alber T, Tsien RY. Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals. Chem Biol. 2009 Nov 25; 16(11):1169-79. PMID: 19942140.
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      54. Aguilera TA, Olson ES, Timmers MM, Jiang T, Tsien RY. Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides. Integr Biol (Camb). 2009 Jun; 1(5-6):371-81. PMID: 20023744.
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      55. Olson ES, Aguilera TA, Jiang T, Ellies LG, Nguyen QT, Wong EH, Gross LA, Tsien RY. In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integr Biol (Camb). 2009 Jun; 1(5-6):382-93. PMID: 20023745.
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      56. Shu X, Royant A, Lin MZ, Aguilera TA, Lev-Ram V, Steinbach PA, Tsien RY. Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome. Science. 2009 May 8; 324(5928):804-7. PMID: 19423828.
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      57. Lin JY, Lin MZ, Steinbach P, Tsien RY. Characterization of engineered channelrhodopsin variants with improved properties and kinetics. Biophys J. 2009 Mar 4; 96(5):1803-14. PMID: 19254539.
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      58. Tsien RY. Constructing and exploiting the fluorescent protein paintbox (Nobel Lecture). Angew Chem Int Ed Engl. 2009; 48(31):5612-26. PMID: 19565590.
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      59. Wallace DJ, Meyer zum Alten Borgloh S, Astori S, Yang Y, Bausen M, Kügler S, Palmer AE, Tsien RY, Sprengel R, Kerr JN, Denk W, Hasan MT. Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor. Nat Methods. 2008 Sep; 5(9):797-804. PMID: 19160514.
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      60. Shaner NC, Lin MZ, McKeown MR, Steinbach PA, Hazelwood KL, Davidson MW, Tsien RY. Improving the photostability of bright monomeric orange and red fluorescent proteins. Nat Methods. 2008 Jun; 5(6):545-51. PMID: 18454154.
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      61. Adams SR, Tsien RY. Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent labeling of tetracysteine-tagged proteins. Nat Protoc. 2008; 3(9):1527-34. PMID: 18772880.
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      62. Tsien R. Roger Tsien: bringing color to cell biology. A passion for chemistry, color, and conversations with cells is what drives Roger Tsien. Interview by Ruth Williams. J Cell Biol. 2007 Oct 8; 179(1):6-8. PMID: 17923526.
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      63. Martin BR, Deerinck TJ, Ellisman MH, Taylor SS, Tsien RY. Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Chem Biol. 2007 Sep; 14(9):1031-42. PMID: 17884635.
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      64. Hauser CT, Tsien RY. A hexahistidine-Zn2+-dye label reveals STIM1 surface exposure. Proc Natl Acad Sci U S A. 2007 Mar 6; 104(10):3693-7. PMID: 17360414.
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      65. Kunkel MT, Toker A, Tsien RY, Newton AC. Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. J Biol Chem. 2007 Mar 2; 282(9):6733-42. PMID: 17189263.
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      66. Dunn TA, Wang CT, Colicos MA, Zaccolo M, DiPilato LM, Zhang J, Tsien RY, Feller MB. Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades. J Neurosci. 2006 Dec 6; 26(49):12807-15. PMID: 17151284.
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      67. Tsien RY. Breeding and building molecules to spy on cells and tumors. Keio J Med. 2006 Dec; 55(4):127-40. PMID: 17191067.
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      68. Gaietta GM, Giepmans BN, Deerinck TJ, Smith WB, Ngan L, Llopis J, Adams SR, Tsien RY, Ellisman MH. Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17777-82. PMID: 17101980.
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      69. Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD. Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc Natl Acad Sci U S A. 2006 Aug 22; 103(34):12923-8. PMID: 16905651.
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      70. Giepmans BN, Adams SR, Ellisman MH, Tsien RY. The fluorescent toolbox for assessing protein location and function. Science. 2006 Apr 14; 312(5771):217-24. PMID: 16614209.
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      71. Babendure JR, Babendure JL, Ding JH, Tsien RY. Control of mammalian translation by mRNA structure near caps. RNA. 2006 May; 12(5):851-61. PMID: 16540693.
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      72. Wang L, Tsien RY. Evolving proteins in mammalian cells using somatic hypermutation. Nat Protoc. 2006; 1(3):1346-50. PMID: 17406421.
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      73. Sun M, Oakes JL, Ananthanarayanan SK, Hawley KH, Tsien RY, Adams SR, Yengo CM. Dynamics of the upper 50-kDa domain of myosin V examined with fluorescence resonance energy transfer. J Biol Chem. 2006 Mar 3; 281(9):5711-7. PMID: 16377637.
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      74. Shaner NC, Steinbach PA, Tsien RY. A guide to choosing fluorescent proteins. Nat Methods. 2005 Dec; 2(12):905-9. PMID: 16299475.
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      75. Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 2005 Sep 22; 437(7058):569-73. PMID: 16177793.
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      76. Martin BR, Giepmans BN, Adams SR, Tsien RY. Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity. Nat Biotechnol. 2005 Oct; 23(10):1308-14. PMID: 16155565.
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      77. Wang Y, Botvinick EL, Zhao Y, Berns MW, Usami S, Tsien RY, Chien S. Visualizing the mechanical activation of Src. Nature. 2005 Apr 21; 434(7036):1040-5. PMID: 15846350.
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      78. Hoffmann C, Gaietta G, Bünemann M, Adams SR, Oberdorff-Maass S, Behr B, Vilardaga JP, Tsien RY, Ellisman MH, Lohse MJ. A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nat Methods. 2005 Mar; 2(3):171-6. PMID: 15782185.
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      79. Tsien RY. Building and breeding molecules to spy on cells and tumors. FEBS Lett. 2005 Feb 7; 579(4):927-32. PMID: 15680976.
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      80. Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem. 2005 Feb 18; 280(7):5581-7. PMID: 15583002.
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      81. Wang L, Jackson WC, Steinbach PA, Tsien RY. Evolution of new nonantibody proteins via iterative somatic hypermutation. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16745-9. PMID: 15556995.
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      82. Chae HJ, Kim HR, Xu C, Bailly-Maitre B, Krajewska M, Krajewski S, Banares S, Cui J, Digicaylioglu M, Ke N, Kitada S, Monosov E, Thomas M, Kress CL, Babendure JR, Tsien RY, Lipton SA, Reed JC. BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol Cell. 2004 Aug 13; 15(3):355-66. PMID: 15304216.
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      83. Hasan MT, Friedrich RW, Euler T, Larkum ME, Giese G, Both M, Duebel J, Waters J, Bujard H, Griesbeck O, Tsien RY, Nagai T, Miyawaki A, Denk W. Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control. PLoS Biol. 2004 Jun; 2(6):e163. PMID: 15208716.
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      84. Dooley CT, Dore TM, Hanson GT, Jackson WC, Remington SJ, Tsien RY. Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators. J Biol Chem. 2004 May 21; 279(21):22284-93. PMID: 14985369.
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      85. Ray P, De A, Min JJ, Tsien RY, Gambhir SS. Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Res. 2004 Feb 15; 64(4):1323-30. PMID: 14973078.
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      86. Ju W, Morishita W, Tsui J, Gaietta G, Deerinck TJ, Adams SR, Garner CC, Tsien RY, Ellisman MH, Malenka RC. Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors. Nat Neurosci. 2004 Mar; 7(3):244-53. PMID: 14770185.
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      87. Hanson GT, Aggeler R, Oglesbee D, Cannon M, Capaldi RA, Tsien RY, Remington SJ. Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators. J Biol Chem. 2004 Mar 26; 279(13):13044-53. PMID: 14722062.
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      88. Lev-Ram V, Mehta SB, Kleinfeld D, Tsien RY. Reversing cerebellar long-term depression. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15989-93. PMID: 14671315.
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      89. Babendure JR, Adams SR, Tsien RY. Aptamers switch on fluorescence of triphenylmethane dyes. J Am Chem Soc. 2003 Dec 3; 125(48):14716-7. PMID: 14640641.
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      90. Hasegawa S, Jackson WC, Tsien RY, Rao J. Imaging Tetrahymena ribozyme splicing activity in single live mammalian cells. Proc Natl Acad Sci U S A. 2003 Dec 9; 100(25):14892-6. PMID: 14645710.
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      91. Gao W, Xing B, Tsien RY, Rao J. Novel fluorogenic substrates for imaging beta-lactamase gene expression. J Am Chem Soc. 2003 Sep 17; 125(37):11146-7. PMID: 16220906.
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      92. Tsien RY. Imagining imaging's future. Nat Rev Mol Cell Biol. 2003 Sep; Suppl:SS16-21. PMID: 14587522.
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      93. Tsai PS, Friedman B, Ifarraguerri AI, Thompson BD, Lev-Ram V, Schaffer CB, Xiong Q, Tsien RY, Squier JA, Kleinfeld D. All-optical histology using ultrashort laser pulses. Neuron. 2003 Jul 3; 39(1):27-41. PMID: 12848930.
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      94. Sosinsky GE, Gaietta GM, Hand G, Deerinck TJ, Han A, Mackey M, Adams SR, Bouwer J, Tsien RY, Ellisman MH. Tetracysteine genetic tags complexed with biarsenical ligands as a tool for investigating gap junction structure and dynamics. Cell Commun Adhes. 2003 Jul-Dec; 10(4-6):181-6. PMID: 14681013.
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      95. Violin JD, Zhang J, Tsien RY, Newton AC. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol. 2003 Jun 9; 161(5):899-909. PMID: 12782683.
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      96. Yu D, Baird GS, Tsien RY, Davis RL. Detection of calcium transients in Drosophila mushroom body neurons with camgaroo reporters. J Neurosci. 2003 Jan 1; 23(1):64-72. PMID: 12514202.
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      97. Tsien RY. Breeding molecules to spy on cells. Harvey Lect. 2003-2004; 99:77-93. PMID: 15984552.
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      98. Zhang J, Campbell RE, Ting AY, Tsien RY. Creating new fluorescent probes for cell biology. Nat Rev Mol Cell Biol. 2002 Dec; 3(12):906-18. PMID: 12461557.
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      99. Campbell RE, Tour O, Palmer AE, Steinbach PA, Baird GS, Zacharias DA, Tsien RY. A monomeric red fluorescent protein. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):7877-82. PMID: 12060735.
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      100. Lev-Ram V, Wong ST, Storm DR, Tsien RY. A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8389-93. PMID: 12048250.
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      101. Adams SR, Campbell RE, Gross LA, Martin BR, Walkup GK, Yao Y, Llopis J, Tsien RY. New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications. J Am Chem Soc. 2002 May 29; 124(21):6063-76. PMID: 12022841.
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      102. Zacharias DA, Violin JD, Newton AC, Tsien RY. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science. 2002 May 3; 296(5569):913-6. PMID: 11988576.
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      103. Gaietta G, Deerinck TJ, Adams SR, Bouwer J, Tour O, Laird DW, Sosinsky GE, Tsien RY, Ellisman MH. Multicolor and electron microscopic imaging of connexin trafficking. Science. 2002 Apr 19; 296(5567):503-7. PMID: 11964472.
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      104. Tsien RY, Miyawaki A. Seeing the machinery of live cells. Science. 1998 Jun 19; 280(5371):1954-5. PMID: 9669950.
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