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    Peter Ernst

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPathology
    Address9500 Gilman Drive #0063
    CA La Jolla 92093
    Phone858-534-2975
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      Collapse Biography 
      Collapse Education and Training
      University of Toronto (Trinity College) BScGastrointestinal Physiology1977
      Ontario Veterinary College, Univ of GuelphDVM Veterinary Medicine1981
      Ontario Veterinary College, Univ of GuelphMScEpidemiology1981
      McMaster UniversityPodtdocMucosal Immunology 1985
      McMaster UniversityPhDMucosal Immunology1986

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      Collapse NIH Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016 May 27; 352(6289):1116-20. PMID: 27230380.
        View in: PubMed
      2. den Hartog G, Chattopadhyay R, Ablack A, Hall EH, Butcher LD, Bhattacharyya A, Eckmann L, Harris PR, Das S, Ernst PB, Crowe SE. Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia. PLoS Pathog. 2016 Jan; 12(1):e1005382. PMID: 26761793.
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      3. Fox S, Ryan KA, Berger AH, Petro K, Das S, Crowe SE, Ernst PB. The role of C1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during Helicobacter pylori infection. J Inflamm (Lond). 2015; 12:51. PMID: 26357509.
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      4. Das S, Sarkar A, Choudhury SS, Owen KA, Castillo V, Fox S, Eckmann L, Elliott MR, Casanova JE, Ernst PB. ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. Cell Mol Gastroenterol Hepatol. 2015 Apr 1; 1(3):311-324. PMID: 26878033.
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      5. Faillie JL, Filion KB, Patenaude V, Ernst P, Azoulay L. Dipeptidyl peptidase-4 inhibitors and the risk of community-acquired pneumonia in patients with type 2 diabetes. Diabetes Obes Metab. 2015 Apr; 17(4):379-85. PMID: 25581902.
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      6. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT. Validation of Gene Expression Biomarker Analysis for Biopsy-based Clinical Trials in Crohn's Disease. Inflamm Bowel Dis. 2015 Feb; 21(2):323-30. PMID: 25545378.
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      7. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT. Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis. Aliment Pharmacol Ther. 2014 Sep; 40(5):477-85. PMID: 25041724.
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      8. Kurtz CC, Drygiannakis I, Naganuma M, Feldman S, Bekiaris V, Linden J, Ware CF, Ernst PB. Extracellular adenosine regulates colitis through effects on lymphoid and nonlymphoid cells. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 1; 307(3):G338-46. PMID: 24875104.
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      9. Chang JT, Sandborn WJ, Ernst PB. Studies in human intestinal tissues: is it time to reemphasize research in human immunology? Gastroenterology. 2014 Jul; 147(1):26-30. PMID: 24877864.
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      10. Alam MS, Kuo JL, Ernst PB, Derr-Castillo V, Pereira M, Gaines D, Costales M, Bigley E, Williams K. Ecto-5'-nucleotidase (CD73) regulates host inflammatory responses and exacerbates murine salmonellosis. Sci Rep. 2014; 4:4486. PMID: 24670982.
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      11. Das S, Sarkar A, Ryan KA, Fox S, Berger AH, Juncadella IJ, Bimczok D, Smythies LE, Harris PR, Ravichandran KS, Crowe SE, Smith PD, Ernst PB. Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells. FASEB J. 2014 May; 28(5):2214-24. PMID: 24509909.
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      12. Bimczok D, Smythies LE, Waites KB, Grams JM, Stahl RD, Mannon PJ, Peter S, Wilcox CM, Harris PR, Das S, Ernst PB, Smith PD. Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells. J Immunol. 2013 Jun 15; 190(12):6626-34. PMID: 23686492.
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      13. Mauldin JP, Lu M, Das S, Park D, Ernst PB, Ravichandran KS. A link between the cytoplasmic engulfment protein Elmo1 and the Mediator complex subunit Med31. Curr Biol. 2013 Jan 21; 23(2):162-7. PMID: 23273896.
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      14. Tlaxca JL, Rychak JJ, Ernst PB, Konkalmatt PR, Shevchenko TI, Pizzaro TT, Rivera-Nieves J, Klibanov AL, Lawrence MB. Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease. J Control Release. 2013 Feb 10; 165(3):216-25. PMID: 23142578.
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      15. Röpcke S, Holz O, Lauer G, Müller M, Rittinghausen S, Ernst P, Lahu G, Elmlinger M, Krug N, Hohlfeld JM. Repeatability of and relationship between potential COPD biomarkers in bronchoalveolar lavage, bronchial biopsies, serum, and induced sputum. PLoS One. 2012; 7(10):e46207. PMID: 23056262.
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      16. Luo Y, Kong Q, Yang J, Mitra A, Golden G, Wanda SY, Roland KL, Jensen RV, Ernst PB, Curtiss R. Comparative genome analysis of the high pathogenicity Salmonella Typhimurium strain UK-1. PLoS One. 2012; 7(7):e40645. PMID: 22792393.
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      17. Warren CA, Calabrese GM, Li Y, Pawlowski SW, Figler RA, Rieger J, Ernst PB, Linden J, Guerrant RL. Effects of adenosine A2A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice. BMC Infect Dis. 2012; 12:13. PMID: 22264229.
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      18. Ernst PB, Erickson LD, Loo WM, Scott KG, Wiznerowicz EB, Brown CC, Torres-Velez FJ, Alam MS, Black SG, McDuffie M, Feldman SH, Wallace JL, McKnight GW, Padol IT, Hunt RH, Tung KS. Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice. Am J Physiol Gastrointest Liver Physiol. 2012 Jan 1; 302(1):G105-15. PMID: 21921286.
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      19. DeLyria ES, Nedrud JG, Ernst PB, Alam MS, Redline RW, Ding H, Czinn SJ, Xu J, Blanchard TG. Vaccine-induced immunity against Helicobacter pylori in the absence of IL-17A. Helicobacter. 2011 Jun; 16(3):169-78. PMID: 21585602.
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      20. Luo Y, Kong Q, Yang J, Golden G, Wanda SY, Jensen RV, Ernst PB, Curtiss R. Complete genome sequence of the universal killer Salmonella enterica Serovar Typhimurium UK-1 (ATCC 68169). J Bacteriol. 2011 Aug; 193(15):4035-6. PMID: 21622747.
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      21. Wilson JM, Kurtz CC, Black SG, Ross WG, Alam MS, Linden J, Ernst PB. The A2B adenosine receptor promotes Th17 differentiation via stimulation of dendritic cell IL-6. J Immunol. 2011 Jun 15; 186(12):6746-52. PMID: 21593380.
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      22. Drygiannakis I, Ernst PB, Lowe D, Glomski IJ. Immunological alterations mediated by adenosine during host-microbial interactions. Immunol Res. 2011 May; 50(1):69-77. PMID: 21479929.
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      23. Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, Sifri CD, Ravichandran KS, Ernst PB, Casanova JE. Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A. 2011 Feb 1; 108(5):2136-41. PMID: 21245295.
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      24. Ernst PB, Wiznerowicz EB, Feldman SH, Tung KS. Pathogenesis of gastritis in ileitis-prone SAMP1/Yit mice. Keio J Med. 2011; 60(2):65-8. PMID: 21720202.
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      25. Bhattacharyya A, Chattopadhyay R, Hall EH, Mebrahtu ST, Ernst PB, Crowe SE. Mechanism of hypoxia-inducible factor 1 alpha-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1177-86. PMID: 20829524.
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      26. Gan T, Jude CD, Zaffuto K, Ernst P. Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis. Leukemia. 2010 Oct; 24(10):1732-41. PMID: 20724987.
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      27. Ernst PB, Garrison JC, Thompson LF. Much ado about adenosine: adenosine synthesis and function in regulatory T cell biology. J Immunol. 2010 Aug 15; 185(4):1993-8. PMID: 20686167.
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      28. Bhattacharyya A, Chattopadhyay R, Burnette BR, Cross JV, Mitra S, Ernst PB, Bhakat KK, Crowe SE. Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis. Gastroenterology. 2009 Jun; 136(7):2258-69. PMID: 19505426.
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      29. O'Hara AM, Bhattacharyya A, Bai J, Mifflin RC, Ernst PB, Mitra S, Crowe SE. Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1. Cytokine. 2009 Jun; 46(3):359-69. PMID: 19376732.
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      30. Wilson JM, Ross WG, Agbai ON, Frazier R, Figler RA, Rieger J, Linden J, Ernst PB. The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells. J Immunol. 2009 Apr 15; 182(8):4616-23. PMID: 19342636.
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      31. Alam MS, Kurtz CC, Wilson JM, Burnette BR, Wiznerowicz EB, Ross WG, Rieger JM, Figler RA, Linden J, Crowe SE, Ernst PB. A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence. Mucosal Immunol. 2009 May; 2(3):232-42. PMID: 19262506.
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      32. Alam MS, Kurtz CC, Rowlett RM, Reuter BK, Wiznerowicz E, Das S, Linden J, Crowe SE, Ernst PB. CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice. J Infect Dis. 2009 Feb 15; 199(4):494-504. PMID: 19281303.
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      33. Ho J, Kurtz CC, Naganuma M, Ernst PB, Cominelli F, Rivera-Nieves J. A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis. J Immunol. 2008 Feb 15; 180(4):2573-80. PMID: 18250468.
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      34. Minohara Y, Boyd DK, Hawkins HK, Ernst PB, Patel J, Crowe SE. The effect of the cag pathogenicity island on binding of Helicobacter pylori to gastric epithelial cells and the subsequent induction of apoptosis. Helicobacter. 2007 Dec; 12(6):583-90. PMID: 18001397.
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      35. Rowlett RM, Chrestensen CA, Nyce M, Harp MG, Pelo JW, Cominelli F, Ernst PB, Pizarro TT, Sturgill TW, Worthington MT. MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages. Am J Physiol Gastrointest Liver Physiol. 2008 Feb; 294(2):G452-9. PMID: 18032482.
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      36. Ding SZ, Minohara Y, Fan XJ, Wang J, Reyes VE, Patel J, Dirden-Kramer B, Boldogh I, Ernst PB, Crowe SE. Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells. Infect Immun. 2007 Aug; 75(8):4030-9. PMID: 17562777.
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      37. Croxen MA, Ernst PB, Hoffman PS. Antisense RNA modulation of alkyl hydroperoxide reductase levels in Helicobacter pylori correlates with organic peroxide toxicity but not infectivity. J Bacteriol. 2007 May; 189(9):3359-68. PMID: 17337572.
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      38. O'Hara AM, Bhattacharyya A, Mifflin RC, Smith MF, Ryan KA, Scott KG, Naganuma M, Casola A, Izumi T, Mitra S, Ernst PB, Crowe SE. Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1. J Immunol. 2006 Dec 1; 177(11):7990-9. PMID: 17114472.
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      39. Naganuma M, Wiznerowicz EB, Lappas CM, Linden J, Worthington MT, Ernst PB. Cutting edge: Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis. J Immunol. 2006 Sep 1; 177(5):2765-9. PMID: 16920910.
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      40. Smith MF, Gautam JK, Black SG, Ernst PB. Microbial-induced regulation of syndecan expression: important host defense mechanism or an opportunity for pathogens? ScientificWorldJournal. 2006; 6:442-5. PMID: 16604254.
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      41. Olson TS, Reuter BK, Scott KG, Morris MA, Wang XM, Hancock LN, Burcin TL, Cohn SM, Ernst PB, Cominelli F, Meddings JB, Ley K, Pizarro TT. The primary defect in experimental ileitis originates from a nonhematopoietic source. J Exp Med. 2006 Mar 20; 203(3):541-52. PMID: 16505137.
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      42. Ernst PB, Peura DA, Crowe SE. The translation of Helicobacter pylori basic research to patient care. Gastroenterology. 2006 Jan; 130(1):188-206; quiz 212-3. PMID: 16401482.
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      43. Ernst PB. Understanding immunity to Helicobacter pylori: unraveling the riddle, wrapped in a mystery, inside an enigma. Gastroenterology. 2005 Jul; 129(1):380-3. PMID: 16012971.
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      44. Barrera CA, Beswick EJ, Sierra JC, Bland D, Espejo R, Mifflin R, Adegboyega P, Crowe SE, Ernst PB, Reyes VE. Polarized expression of CD74 by gastric epithelial cells. J Histochem Cytochem. 2005 Dec; 53(12):1481-9. PMID: 15923369.
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      45. Nurgalieva ZZ, Conner ME, Opekun AR, Zheng CQ, Elliott SN, Ernst PB, Osato M, Estes MK, Graham DY. B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans. Infect Immun. 2005 May; 73(5):2999-3006. PMID: 15845507.
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      46. Huiart L, Ernst P, Ranouil X, Suissa S. Low-dose inhaled corticosteroids and the risk of acute myocardial infarction in COPD. Eur Respir J. 2005 Apr; 25(4):634-9. PMID: 15802336.
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      47. Ding SZ, O'Hara AM, Denning TL, Dirden-Kramer B, Mifflin RC, Reyes VE, Ryan KA, Elliott SN, Izumi T, Boldogh I, Mitra S, Ernst PB, Crowe SE. Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells. Gastroenterology. 2004 Sep; 127(3):845-58. PMID: 15362040.
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      48. Olson TS, Bamias G, Naganuma M, Rivera-Nieves J, Burcin TL, Ross W, Morris MA, Pizarro TT, Ernst PB, Cominelli F, Ley K. Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease. J Clin Invest. 2004 Aug; 114(3):389-98. PMID: 15286805.
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      49. Duck WM, Sobel J, Pruckler JM, Song Q, Swerdlow D, Friedman C, Sulka A, Swaminathan B, Taylor T, Hoekstra M, Griffin P, Smoot D, Peek R, Metz DC, Bloom PB, Goldschmidt S, Parsonnet J, Triadafilopoulos G, Perez-Perez GI, Vakil N, Ernst P, Czinn S, Dunne D, Gold BD. Antimicrobial resistance incidence and risk factors among Helicobacter pylori-infected persons, United States. Emerg Infect Dis. 2004 Jun; 10(6):1088-94. PMID: 15207062.
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      50. Wendelbo Ø, Nesthus I, Sjo M, Paulsen K, Ernst P, Bruserud Ø. Functional characterization of T lymphocytes derived from patients with acute myelogenous leukemia and chemotherapy-induced leukopenia. Cancer Immunol Immunother. 2004 Aug; 53(8):740-7. PMID: 15133630.
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      51. Ryan KA, Smith MF, Sanders MK, Ernst PB. Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF-kappa B and interleukin-8 expression. Infect Immun. 2004 Apr; 72(4):2123-30. PMID: 15039334.
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      52. Haeberle HA, Casola A, Gatalica Z, Petronella S, Dieterich HJ, Ernst PB, Brasier AR, Garofalo RP. IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection. J Virol. 2004 Mar; 78(5):2232-41. PMID: 14963119.
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      53. Denning TL, Qi H, König R, Scott KG, Naganuma M, Ernst PB. CD4+ Th cells resembling regulatory T cells that inhibit chronic colitis differentiate in the absence of interactions between CD4 and class II MHC. J Immunol. 2003 Sep 1; 171(5):2279-86. PMID: 12928372.
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      54. Bourbeau J, Ernst P, Cockcoft D, Suissa S. Inhaled corticosteroids and hospitalisation due to exacerbation of COPD. Eur Respir J. 2003 Aug; 22(2):286-9. PMID: 12952262.
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      55. Denning TL, Takaishi H, Crowe SE, Boldogh I, Jevnikar A, Ernst PB. Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells. Free Radic Biol Med. 2002 Dec 15; 33(12):1641-50. PMID: 12488132.
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      56. Takata T, El-Omar E, Camorlinga M, Thompson SA, Minohara Y, Ernst PB, Blaser MJ. Helicobacter pylori does not require Lewis X or Lewis Y expression to colonize C3H/HeJ mice. Infect Immun. 2002 Jun; 70(6):3073-9. PMID: 12011000.
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      57. Barrera C, Ye G, Espejo R, Gunasena S, Almanza R, Leary J, Crowe S, Ernst P, Reyes VE. Expression of cathepsins B, L, S, and D by gastric epithelial cells implicates them as antigen presenting cells in local immune responses. Hum Immunol. 2001 Oct; 62(10):1081-91. PMID: 11600214.
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      58. Ernst PB, Pappo J. T-cell-mediated mucosal immunity in the absence of antibody: lessons from Helicobacter pylori infection. Acta Odontol Scand. 2001 Aug; 59(4):216-21. PMID: 11570524.
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      59. Trinh LA, Ferrini R, Cobb BS, Weinmann AS, Hahm K, Ernst P, Garraway IP, Merkenschlager M, Smale ST. Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator. Genes Dev. 2001 Jul 15; 15(14):1817-32. PMID: 11459831.
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      60. Wang J, Brooks EG, Bamford KB, Denning TL, Pappo J, Ernst PB. Negative selection of T cells by Helicobacter pylori as a model for bacterial strain selection by immune evasion. J Immunol. 2001 Jul 15; 167(2):926-34. PMID: 11441100.
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      61. Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ. MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol Cell Biol. 2001 Apr; 21(7):2249-58. PMID: 11259575.
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      62. Ernst PB, Takaishi H, Crowe SE. Helicobacter pylori infection as a model for gastrointestinal immunity and chronic inflammatory diseases. Dig Dis. 2001; 19(2):104-11. PMID: 11549818.
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      63. Benayoun S, Ernst P, Suissa S. The impact of combined inhaled bronchodilator therapy in the treatment of COPD. Chest. 2001 Jan; 119(1):85-92. PMID: 11157588.
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      64. Goldberg MS, Bailar JC, Burnett RT, Brook JR, Tamblyn R, Bonvalot Y, Ernst P, Flegel KM, Singh RK, Valois MF. Identifying subgroups of the general population that may be susceptible to short-term increases in particulate air pollution: a time-series study in Montreal, Quebec. Res Rep Health Eff Inst. 2000 Oct; (97):7-113; discussion 115-20. PMID: 11244610.
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      65. Ernst PB, Pappo J. Preventive and therapeutic vaccines against Helicobacter pylori: current status and future challenges. Curr Pharm Des. 2000 Oct; 6(15):1557-73. PMID: 10974152.
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      66. Fan X, Gunasena H, Cheng Z, Espejo R, Crowe SE, Ernst PB, Reyes VE. Helicobacter pylori urease binds to class II MHC on gastric epithelial cells and induces their apoptosis. J Immunol. 2000 Aug 15; 165(4):1918-24. PMID: 10925273.
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      67. Wang J, Fan X, Lindholm C, Bennett M, O'Connoll J, Shanahan F, Brooks EG, Reyes VE, Ernst PB. Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas ligand interactions. Infect Immun. 2000 Jul; 68(7):4303-11. PMID: 10858249.
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      68. Ito K, Takaishi H, Jin Y, Song F, Denning TL, Ernst PB. Staphylococcal enterotoxin B stimulates expansion of autoreactive T cells that induce apoptosis in intestinal epithelial cells: regulation of autoreactive responses by IL-10. J Immunol. 2000 Mar 15; 164(6):2994-3001. PMID: 10706687.
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      69. Denning TL, Campbell NA, Song F, Garofalo RP, Klimpel GR, Reyes VE, Ernst PB. Expression of IL-10 receptors on epithelial cells from the murine small and large intestine. Int Immunol. 2000 Feb; 12(2):133-9. PMID: 10653848.
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      70. Ernst PB, Gold BD. The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu Rev Microbiol. 2000; 54:615-40. PMID: 11018139.
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      71. Demissie K, Hanley JA, Menzies D, Joseph L, Ernst P. Agreement in measuring socio-economic status: area-based versus individual measures. Chronic Dis Can. 2000; 21(1):1-7. PMID: 10813687.
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      72. Sun J, Dirden-Kramer B, Ito K, Ernst PB, Van Houten N. Antigen-specific T cell activation and proliferation during oral tolerance induction. J Immunol. 1999 May 15; 162(10):5868-75. PMID: 10229822.
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      73. Ernst PB, Gold BD. Helicobacter pylori in childhood: new insights into the immunopathogenesis of gastric disease and implications for managing infection in children. J Pediatr Gastroenterol Nutr. 1999 May; 28(5):462-73. PMID: 10328119.
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      74. Ernst PB, Song F, Klimpel GR, Haeberle H, Bamford KB, Crowe SE, Ye G, Reyes VE. Regulation of the mucosal immune response. Am J Trop Med Hyg. 1999 Apr; 60(4 Suppl):2-9. PMID: 10344671.
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      75. Ernst P. Review article: the role of inflammation in the pathogenesis of gastric cancer. Aliment Pharmacol Ther. 1999 Mar; 13 Suppl 1:13-8. PMID: 10209682.
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      76. Blaser MJ, Kuipers EJ, Ernst P, Axon A, Mégraud F. Panel discussion: breaking the link--clinical options to minimize risk. Aliment Pharmacol Ther. 1999 Mar; 13 Suppl 1:19-23. PMID: 10209683.
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      77. Song F, Ito K, Denning TL, Kuninger D, Papaconstantinou J, Gourley W, Klimpel G, Balish E, Hokanson J, Ernst PB. Expression of the neutrophil chemokine KC in the colon of mice with enterocolitis and by intestinal epithelial cell lines: effects of flora and proinflammatory cytokines. J Immunol. 1999 Feb 15; 162(4):2275-80. PMID: 9973504.
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      78. Harris PR, Ernst PB, Kawabata S, Kiyono H, Graham MF, Smith PD. Recombinant Helicobacter pylori urease activates primary mucosal macrophages. J Infect Dis. 1998 Nov; 178(5):1516-20. PMID: 9780278.
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      79. Yannariello-brown J, Hallberg CK, Häberle H, Brysk MM, Jiang Z, Patel JA, Ernst PB, Trocme SD. Cytokine modulation of human corneal epithelial cell ICAM-1 (CD54) expression. Exp Eye Res. 1998 Oct; 67(4):383-93. PMID: 9820785.
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      80. Suissa S, Bourgault C, Barkun A, Sheehy O, Ernst P. Antihypertensive drugs and the risk of gastrointestinal bleeding. Am J Med. 1998 Sep; 105(3):230-5. PMID: 9753026.
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      81. Saleh D, Ernst P, Lim S, Barnes PJ, Giaid A. Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid. FASEB J. 1998 Aug; 12(11):929-37. PMID: 9707165.
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      82. Demissie K, Ernst P, Joseph L, Becklake MR. The role of domestic factors and day-care attendance on lung function of primary school children. Respir Med. 1998 Jul; 92(7):928-35. PMID: 10070566.
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      83. Fan X, Crowe SE, Behar S, Gunasena H, Ye G, Haeberle H, Van Houten N, Gourley WK, Ernst PB, Reyes VE. The effect of class II major histocompatibility complex expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells: a mechanism for T helper cell type 1-mediated damage. J Exp Med. 1998 May 18; 187(10):1659-69. PMID: 9584144.
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      84. Casola A, Estes MK, Crawford SE, Ogra PL, Ernst PB, Garofalo RP, Crowe SE. Rotavirus infection of cultured intestinal epithelial cells induces secretion of CXC and CC chemokines. Gastroenterology. 1998 May; 114(5):947-55. PMID: 9558283.
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      85. Bamford KB, Fan X, Crowe SE, Leary JF, Gourley WK, Luthra GK, Brooks EG, Graham DY, Reyes VE, Ernst PB. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype. Gastroenterology. 1998 Mar; 114(3):482-92. PMID: 9496938.
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      86. Ernst PB, Crowe SE, Reyes VE. How does Helicobacter pylori cause mucosal damage? The inflammatory response. Gastroenterology. 1997 Dec; 113(6 Suppl):S35-42; discussion S50. PMID: 9394758.
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      87. Collet JP, Shapiro P, Ernst P, Renzi T, Ducruet T, Robinson A. Effects of an immunostimulating agent on acute exacerbations and hospitalizations in patients with chronic obstructive pulmonary disease. The PARI-IS Study Steering Committee and Research Group. Prevention of Acute Respiratory Infection by an Immunostimulant. Am J Respir Crit Care Med. 1997 Dec; 156(6):1719-24. PMID: 9412546.
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      88. Ernst PB. "Déjà vu all over again". Gut. 1997 Oct; 41(4):569-70. PMID: 9391263.
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      89. Haeberle HA, Kubin M, Bamford KB, Garofalo R, Graham DY, El-Zaatari F, Karttunen R, Crowe SE, Reyes VE, Ernst PB. Differential stimulation of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa. Infect Immun. 1997 Oct; 65(10):4229-35. PMID: 9317031.
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      90. Ye G, Barrera C, Fan X, Gourley WK, Crowe SE, Ernst PB, Reyes VE. Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells: potential role in CD4+ T cell activation during Helicobacter pylori infection. J Clin Invest. 1997 Apr 1; 99(7):1628-36. PMID: 9120006.
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      91. Saito T, Deskin RW, Casola A, Häeberle H, Olszewska B, Ernst PB, Alam R, Ogra PL, Garofalo R. Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells. J Infect Dis. 1997 Mar; 175(3):497-504. PMID: 9041319.
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      92. Blais L, Ernst P, Suissa S. Confounding by indication and channeling over time: the risks of beta 2-agonists. Am J Epidemiol. 1996 Dec 15; 144(12):1161-9. PMID: 8956629.
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      93. Demissie K, Ernst P, Hanley JA, Locher U, Menzies D, Becklake MR. Socioeconomic status and lung function among primary school children in Canada. Am J Respir Crit Care Med. 1996 Feb; 153(2):719-23. PMID: 8564123.
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      94. Joseph KS, Blais L, Ernst P, Suissa S. Increased morbidity and mortality related to asthma among asthmatic patients who use major tranquillisers. BMJ. 1996 Jan 13; 312(7023):79-82. PMID: 8555932.
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      95. Klimpel GR, Chopra AK, Langley KE, Wypych J, Annable CA, Kaiserlian D, Ernst PB, Peterson JW. A role for stem cell factor and c-kit in the murine intestinal tract secretory response to cholera toxin. J Exp Med. 1995 Dec 1; 182(6):1931-42. PMID: 7500039.
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      96. Kajiura JS, MacDougall JD, Ernst PB, Younglai EV. Immune response to changes in training intensity and volume in runners. Med Sci Sports Exerc. 1995 Aug; 27(8):1111-7. PMID: 7476053.
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      97. Ernst P, Demissie K, Joseph L, Locher U, Becklake MR. Socioeconomic status and indicators of asthma in children. Am J Respir Crit Care Med. 1995 Aug; 152(2):570-5. PMID: 7633709.
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      98. Kawabata TT, Burleson GR, Ernst PB, Ullrich SE. Immunotoxicology of regional lymphoid tissue: the respiratory and gastrointestinal tracts and skin. Fundam Appl Toxicol. 1995 Jun; 26(1):8-19. PMID: 7657065.
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      99. Crowe SE, Alvarez L, Dytoc M, Hunt RH, Muller M, Sherman P, Patel J, Jin Y, Ernst PB. Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitro. Gastroenterology. 1995 Jan; 108(1):65-74. PMID: 7806065.
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      100. Suissa S, Blais L, Ernst P. Patterns of increasing beta-agonist use and the risk of fatal or near-fatal asthma. Eur Respir J. 1994 Sep; 7(9):1602-9. PMID: 7995388.
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      101. Ernst PB, Jin Y, Reyes VE, Crowe SE. The role of the local immune response in the pathogenesis of peptic ulcer formation. Scand J Gastroenterol Suppl. 1994; 205:22-8. PMID: 7863238.
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      102. Manganaro M, Ogra PL, Ernst PB. Oral immunization: turning fantasy into reality. Int Arch Allergy Immunol. 1994; 103(3):223-33. PMID: 8111241.
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      103. Delfino RJ, Ernst P, Jaakkola MS, Solomon S, Becklake MR. Questionnaire assessments of recent exposure to environmental tobacco smoke in relation to salivary cotinine. Eur Respir J. 1993 Sep; 6(8):1104-8. PMID: 8224124.
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      104. Bourbeau J, Delfino R, Ernst P. Tracheal size is a determinant of the bronchoconstrictive response to inhaled methacholine. Eur Respir J. 1993 Jul; 6(7):991-5. PMID: 8370448.
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      105. Ernst P, Habbick B, Suissa S, Hemmelgarn B, Cockcroft D, Buist AS, Horwitz RI, McNutt M, Spitzer WO. Is the association between inhaled beta-agonist use and life-threatening asthma because of confounding by severity? Am Rev Respir Dis. 1993 Jul; 148(1):75-9. PMID: 8100409.
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      106. Sherman P, Leslie K, Golderg E, MacMillan J, Hunt R, Ernst P. Helicobacter pylori infection in adolescents with eating disorders and dyspeptic symptoms. J Pediatr. 1993 May; 122(5 Pt 1):824-6. PMID: 8496771.
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      107. Kiyono H, Bienenstock J, McGhee JR, Ernst PB. The mucosal immune system: features of inductive and effector sites to consider in mucosal immunization and vaccine development. Reg Immunol. 1992 Mar-Apr; 4(2):54-62. PMID: 1503889.
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      108. Croitoru K, Ernst PB. Leukocytes in the intestinal epithelium: an unusual immunological compartment revisited. Reg Immunol. 1992 Mar-Apr; 4(2):63-9. PMID: 1386999.
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      109. Pecquet SS, Ehrat C, Ernst PB. Enhancement of mucosal antibody responses to Salmonella typhimurium and the microbial hapten phosphorylcholine in mice with X-linked immunodeficiency by B-cell precursors from the peritoneal cavity. Infect Immun. 1992 Feb; 60(2):503-9. PMID: 1730482.
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      110. Roberts GT, Spence DG, Padmos MA, Sheth KV, Clink H, Ernst P. Morphologic immunophenotypic and cytogenetic patterns of adult acute myeloid leukemia in Saudi Arabia. Leuk Res. 1992; 16(2):181-90. PMID: 1545571.
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      111. D'Inca R, Ernst P, Hunt RH, Perdue MH. Role of T lymphocytes in intestinal mucosal injury. Inflammatory changes in athymic nude rats. Dig Dis Sci. 1992 Jan; 37(1):33-9. PMID: 1728528.
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      112. Ng'Ang'a LW, Ernst P, Jaakkola MS, Gerardi G, Hanley JH, Becklake MR. Spirometric lung function. Distribution and determinants of test failure in a young adult population. Am Rev Respir Dis. 1992 Jan; 145(1):48-52. PMID: 1731598.
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      113. Jaakkola MS, Ernst P, Jaakkola JJ, N'gan'ga LW, Becklake MR. Effect of cigarette smoking on evolution of ventilatory lung function in young adults: an eight year longitudinal study. Thorax. 1991 Dec; 46(12):907-13. PMID: 1792639.
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      114. Infante-Rivard C, Armstrong B, Ernst P, Petitclerc M, Cloutier LG, Thériault G. Descriptive study of prognostic factors influencing survival of compensated silicotic patients. Am Rev Respir Dis. 1991 Nov; 144(5):1070-4. PMID: 1952433.
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      115. Vermillion DL, Ernst PB, Collins SM. T-lymphocyte modulation of intestinal muscle function in the Trichinella-infected rat. Gastroenterology. 1991 Jul; 101(1):31-8. PMID: 1646141.
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      116. Croitoru K, Stead RH, Bienenstock J, Shultz LD, Ernst PB. T cell receptor expression is not required for the localization and differentiation of intraepithelial lymphocytes. Immunol Res. 1991; 10(3-4):293-5. PMID: 1835481.
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      117. Ernst PB, Pecquet S. Interactions between Helicobacter pylori and the local mucosal immune system. Scand J Gastroenterol Suppl. 1991; 187:56-64. PMID: 1775925.
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      118. Zejda J, Ernst P. Fissural thickening and exposure to asbestos: occurrence, determinants, and functional impact. Am J Ind Med. 1991; 20(6):785-93. PMID: 1805615.
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      119. Bourbeau J, Ernst P, Chrome J, Armstrong B, Becklake MR. The relationship between respiratory impairment and asbestos-related pleural abnormality in an active work force. Am Rev Respir Dis. 1990 Oct; 142(4):837-42. PMID: 2221591.
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      120. Croitoru K, Ernst PB, Bienenstock J, Padol I, Stanisz AM. Selective modulation of the natural killer activity of murine intestinal intraepithelial leucocytes by the neuropeptide substance P. Immunology. 1990 Oct; 71(2):196-201. PMID: 1699880.
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      121. Ernst PB, Lee ST, Maeba J, Bienenstock J, Stanisz AM, Paraskevas F. A role for isotype-specific binding factors in the regulation of IgA- and IgG-specific responses by the anti/contrasuppressor T cell circuit. J Immunol. 1989 Sep 1; 143(5):1426-32. PMID: 2569491.
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      122. Lee ST, Maeba J, Ernst PB, Bienenstock J, Paraskevas F. The isotype of an Ig-containing mediator dictates the isotype of the antibody produced: a novel mechanism of isotype regulation. Reg Immunol. 1989 Mar-Apr; 2(2):111-6. PMID: 2534949.
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      123. Ernst P, Dales RE, Nunes F, Becklake MR. Relation of airway responsiveness to duration of work in a dusty environment. Thorax. 1989 Feb; 44(2):116-20. PMID: 2648647.
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      124. Delfino R, Ernst P, Bourbeau J. Relationship of lung geometry to the development of pleural abnormalities in insulation workers exposed to asbestos. Am J Ind Med. 1989; 15(4):417-25. PMID: 2729285.
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      125. Ernst PB, Maeba J, Lee SI, Paraskevas F. A novel mechanism for the selection of isotype-specific antibody responses: the role of intestinal T cells in the regulation of IgA synthesis by the anti-suppressor circuit. Immunology. 1988 Sep; 65(1):59-66. PMID: 2972602.
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      126. Dales RE, Ernst P, Blanchet Y, Bourbeau J. Does seasonal employment in grain elevators increase nonspecific airways responsiveness? J Occup Med. 1988 Aug; 30(8):613-6. PMID: 3049963.
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      127. Masi MA, Hanley JA, Ernst P, Becklake MR. Environmental exposure to tobacco smoke and lung function in young adults. Am Rev Respir Dis. 1988 Aug; 138(2):296-9. PMID: 3195829.
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      128. Bourbeau J, Ernst P. Between- and within-reader variability in the assessment of pleural abnormality using the ILO 1980 international classification of pneumoconioses. Am J Ind Med. 1988; 14(5):537-43. PMID: 3228068.
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      129. Nissen MH, Larsen JK, Plesner T, Olesen BK, Ernst P. Alpha-interferon induces enhanced expression of HLA-ABC antigens and beta-2-microglobulin in vivo and in vitro in various subsets of human lymphoid cells. Clin Exp Immunol. 1987 Sep; 69(3):632-8. PMID: 2959413.
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      130. Carman PS, Ernst PB, Rosenthal KL, Clark DA, Befus DA, Bienenstock J. Natural killer (NK) cell activity against enteric murine coronavirus mediated by intestinal leukocytes. Adv Exp Med Biol. 1987; 216A:533-7. PMID: 2825474.
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      131. Ernst PB, Stanisz AM, Scicchitano R, Paraskevas F, Payan D, Bienenstock J. Novel regulatory mechanisms of IgA synthesis: respective roles of neuropeptides and cells of the anti-suppressor circuit. Adv Exp Med Biol. 1987; 216A:57-68. PMID: 2446471.
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      132. Ernst PB, Clark DA, Rosenthal KL, Befus AD, Bienenstock J. Detection and characterization of cytotoxic T lymphocyte precursors in the murine intestinal intraepithelial leukocyte population. J Immunol. 1986 Mar 15; 136(6):2121-6. PMID: 2936822.
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