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    Paula Desplats

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentPathology
    Address9500 Gilman Drive #0624
    CA La Jolla 92093
    Phone858-822-3182
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Applying DNA methylation for differential diagnosis in Lewy Body Dementia
      NIH/NINDS R03NS104013Sep 25, 2017 - Aug 31, 2019
      Role: Principal Investigator
      Regulation of the oligodendroglial accumulation of alpha-synuclein in Multiple System Atrophy
      NIH/NINDS R01NS092803Apr 1, 2016 - Mar 31, 2021
      Role: Principal Investigator
      Clearance Pathways in the CNS in Aging and HIV
      NIH/NIA R01AG043384May 1, 2012 - Apr 30, 2017
      Role: Co-Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Valera E, Spencer B, Fields JA, Trinh I, Adame A, Mante M, Rockenstein E, Desplats P, Masliah E. Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta Neuropathol Commun. 2017 Jan 05; 5(1):2. PMID: 28057080.
        View in: PubMed
      2. Cronin P, McCarthy MJ, Lim ASP, Salmon DP, Galasko D, Masliah E, De Jager PL, Bennett DA, Desplats P. Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1. Alzheimers Dement. 2017 Jun; 13(6):689-700. PMID: 27883893.
        View in: PubMed
      3. Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. A de novo compound targeting a-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 Dec; 139(Pt 12):3217-3236. PMID: 27679481.
        View in: PubMed
      4. Spencer B, Desplats P, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E. Reducing Endogenous a-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. J Neurosci. 2016 Jul 27; 36(30):7971-84. PMID: 27466341; PMCID: PMC4961781 [Available on 01/27/17].
      5. Rockenstein E, Desplats P, Ubhi K, Mante M, Florio J, Adame A, Winter S, Brandstaetter H, Meier D, Moessler H, Masliah E. Neuropeptide Treatment with Cerebrolysin Enhances the Survival of Grafted Neural Stem Cell in an a-Synuclein Transgenic Model of Parkinson's Disease. J Exp Neurosci. 2015; 9(Suppl 2):131-40. PMID: 27429559; PMCID: PMC4938121.
      6. Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E. Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. J Neuroinflammation. 2016; 13(1):120. PMID: 27220536.
        View in: PubMed
      7. Spencer B, Kim C, Gonzalez T, Bisquertt A, Patrick C, Rockenstein E, Adame A, Lee SJ, Desplats P, Masliah E. a-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease. Hum Mol Genet. 2016 Mar 15; 25(6):1100-15. PMID: 26740557; PMCID: PMC4764192 [Available on 03/15/17].
      8. Kim C, Ojo-Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, Wrasidlo W, Adame A, Nchekwube E, Oyemade O, Okogun J, Chan M, Cottam H, Masliah E. Hypoestoxide reduces neuroinflammation and a-synuclein accumulation in a mouse model of Parkinson's disease. J Neuroinflammation. 2015 Dec 18; 12:236. PMID: 26683203; PMCID: PMC4683943.
      9. Rockenstein E, Desplats P, Ubhi K, Mante M, Florio J, Adame A, Winter S, Brandstaetter H, Meier D, Masliah E. Neuro-peptide treatment with Cerebrolysin improves the survival of neural stem cell grafts in an APP transgenic model of Alzheimer disease. Stem Cell Res. 2015 Jul; 15(1):54-67. PMID: 26209890.
        View in: PubMed
      10. Desplats P. Perinatal programming of neurodevelopment: epigenetic mechanisms and the prenatal shaping of the brain. Adv Neurobiol. 2015; 10:335-61. PMID: 25287548.
        View in: PubMed
      11. Spencer B, Emadi S, Desplats P, Eleuteri S, Michael S, Kosberg K, Shen J, Rockenstein E, Patrick C, Adame A, Gonzalez T, Sierks M, Masliah E. ESCRT-mediated uptake and degradation of brain-targeted a-synuclein single chain antibody attenuates neuronal degeneration in vivo. Mol Ther. 2014 Oct; 22(10):1753-67. PMID: 25008355; PMCID: PMC4428402.
      12. Overk CR, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, Price DL, Patrick C, Desplats P, Masliah E. Hippocampal neuronal cells that accumulate a-synuclein fragments are more vulnerable to Aß oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. Mol Neurodegener. 2014 May 19; 9:18. PMID: 24885390; PMCID: PMC4041038.
      13. Spencer B, Verma I, Desplats P, Morvinski D, Rockenstein E, Adame A, Masliah E. A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis. J Biol Chem. 2014 Jun 20; 289(25):17917-31. PMID: 24825898; PMCID: PMC4067222.
      14. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E. Structural diversity of Alzheimer's disease amyloid-ß dimers and their role in oligomerization and fibril formation. J Alzheimers Dis. 2014; 39(3):583-600. PMID: 24240640; PMCID: PMC4449729.
      15. Masliah E, Dumaop W, Galasko D, Desplats P. Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes. Epigenetics. 2013 Oct; 8(10):1030-8. PMID: 23907097; PMCID: PMC3891683.
      16. Bender A, Desplats P, Spencer B, Rockenstein E, Adame A, Elstner M, Laub C, Mueller S, Koob AO, Mante M, Pham E, Klopstock T, Masliah E. TOM40 mediates mitochondrial dysfunction induced by a-synuclein accumulation in Parkinson's disease. PLoS One. 2013; 8(4):e62277. PMID: 23626796; PMCID: PMC3633917.
      17. Desplats P, Patel P, Kosberg K, Mante M, Patrick C, Rockenstein E, Fujita M, Hashimoto M, Masliah E. Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease. Mol Neurodegener. 2012 Sep 28; 7:49. PMID: 23017109; PMCID: PMC3502617.
      18. Bae EJ, Lee HJ, Rockenstein E, Ho DH, Park EB, Yang NY, Desplats P, Masliah E, Lee SJ. Antibody-aided clearance of extracellular a-synuclein prevents cell-to-cell aggregate transmission. J Neurosci. 2012 Sep 26; 32(39):13454-69. PMID: 23015436; PMCID: PMC3752153.
      19. Desplats P, Spencer B, Crews L, Pathel P, Morvinski-Friedmann D, Kosberg K, Roberts S, Patrick C, Winner B, Winkler J, Masliah E. a-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1. J Biol Chem. 2012 Sep 14; 287(38):31691-702. PMID: 22833673; PMCID: PMC3442504.
      20. Reznichenko L, Cheng Q, Nizar K, Gratiy SL, Saisan PA, Rockenstein EM, González T, Patrick C, Spencer B, Desplats P, Dale AM, Devor A, Masliah E. In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy. J Neurosci. 2012 Jul 18; 32(29):9992-8. PMID: 22815513; PMCID: PMC3491088.
      21. Tang B, Becanovic K, Desplats P, Spencer B, Hill AM, Connolly C, Masliah E, Leavitt BR, Thomas EA. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease. Hum Mol Genet. 2012 Jul 15; 21(14):3097-111. PMID: 22492998; PMCID: PMC3384380.
      22. Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats P, Crews L, Spencer B, Masliah E. Role of a-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J. 2012 Mar; 279(6):1000-13. PMID: 22251432; PMCID: PMC3925782.
      23. Lee SJ, Desplats P, Lee HJ, Spencer B, Masliah E. Cell-to-cell transmission of a-synuclein aggregates. Methods Mol Biol. 2012; 849:347-59. PMID: 22528101; PMCID: PMC4940116.
      24. Patrick C, Crews L, Desplats P, Dumaop W, Rockenstein E, Achim CL, Everall IP, Masliah E. Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine. Am J Pathol. 2011 Apr; 178(4):1646-61. PMID: 21435449; PMCID: PMC3078446.
      25. Winner B, Jappelli R, Maji SK, Desplats P, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4194-9. PMID: 21325059; PMCID: PMC3053976.
      26. Desplats P, Spencer B, Coffee E, Patel P, Michael S, Patrick C, Adame A, Rockenstein E, Masliah E. Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J Biol Chem. 2011 Mar 18; 286(11):9031-7. PMID: 21296890; PMCID: PMC3059002.
      27. Price DL, Rockenstein E, Ubhi K, Phung V, MacLean-Lewis N, Askay D, Cartier A, Spencer B, Patrick C, Desplats P, Ellisman MH, Masliah E. Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity. PLoS One. 2010 Nov 16; 5(11):e14020. PMID: 21103359; PMCID: PMC2982819.
      28. Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol. 2010 12; 6(12):702-6. PMID: 21045796; PMCID: PMC4996353.
      29. Denny CA, Desplats P, Thomas EA, Seyfried TN. Cerebellar lipid differences between R6/1 transgenic mice and humans with Huntington's disease. J Neurochem. 2010 Nov; 115(3):748-58. PMID: 20731757.
        View in: PubMed
      30. Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One. 2010 Feb 19; 5(2):e9313. PMID: 20174468; PMCID: PMC2824828.
      31. Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):13010-5. PMID: 19651612; PMCID: PMC2722313.
      32. Winner B, Desplats P, Hagl C, Klucken J, Aigner R, Ploetz S, Laemke J, Karl A, Aigner L, Masliah E, Buerger E, Winkler J. Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model. Exp Neurol. 2009 Oct; 219(2):543-52. PMID: 19619535; PMCID: PMC5038985.
      33. Thomas EA, Coppola G, Desplats P, Tang B, Soragni E, Burnett R, Gao F, Fitzgerald KM, Borok JF, Herman D, Geschwind DH, Gottesfeld JM. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15564-9. PMID: 18829438; PMCID: PMC2563081.
      34. Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008 Sep 04; 3(9):e3135. PMID: 18769546; PMCID: PMC2519786.
      35. Desplats P, Lambert JR, Thomas EA. Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease. Neurobiol Dis. 2008 Sep; 31(3):298-308. PMID: 18595722; PMCID: PMC2569875.
      36. Crews L, Mizuno H, Desplats P, Rockenstein E, Adame A, Patrick C, Winner B, Winkler J, Masliah E. Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice. J Neurosci. 2008 Apr 16; 28(16):4250-60. PMID: 18417705; PMCID: PMC2666311.
      37. Desplats P, Denny CA, Kass KE, Gilmartin T, Head SR, Sutcliffe JG, Seyfried TN, Thomas EA. Glycolipid and ganglioside metabolism imbalances in Huntington's disease. Neurobiol Dis. 2007 Sep; 27(3):265-77. PMID: 17600724; PMCID: PMC2082128.
      38. Desplats P, Kass KE, Gilmartin T, Stanwood GD, Woodward EL, Head SR, Sutcliffe JG, Thomas EA. Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease. J Neurochem. 2006 Feb; 96(3):743-57. PMID: 16405510.
        View in: PubMed
      39. Desplats P, Folco E, Salerno GL. Sucrose may play an additional role to that of an osmolyte in Synechocystis sp. PCC 6803 salt-shocked cells. Plant Physiol Biochem. 2005 Feb; 43(2):133-8. PMID: 15820660.
        View in: PubMed
      40. Miller TR, Hnilicka K, Dziedzic A, Desplats P, Belas R. Chemotaxis of Silicibacter sp. strain TM1040 toward dinoflagellate products. Appl Environ Microbiol. 2004 Aug; 70(8):4692-701. PMID: 15294804; PMCID: PMC492323.
      41. Curatti L, Folco E, Desplats P, Abratti G, Limones V, Herrera-Estrella L, Salerno G. Sucrose-phosphate synthase from Synechocystis sp. strain PCC 6803: identification of the spsA gene and characterization of the enzyme expressed in Escherichia coli. J Bacteriol. 1998 Dec; 180(24):6776-9. PMID: 9852031; PMCID: PMC107790.