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    Olivia Osborn

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0673
    CA La Jolla 92093
    Phone858-822-6645
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lackey DE, Lazaro RG, Li P, Johnson A, Hernandez-Carretero A, Weber N, Vorobyova I, Tsukomoto H, Osborn O. The role of dietary fat in obesity-induced insulin resistance. Am J Physiol Endocrinol Metab. 2016 Dec 01; 311(6):E989-E997. PMID: 27802965.
        View in: PubMed
      2. Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky JM. Adipocyte SIRT1 knockout promotes PPAR? activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mol Metab. 2015 May; 4(5):378-91. PMID: 25973386; PMCID: PMC4421024.
      3. Morinaga H, Mayoral R, Heinrichsdorff J, Osborn O, Franck N, Hah N, Walenta E, Bandyopadhyay G, Pessentheiner AR, Chi TJ, Chung H, Bogner-Strauss JG, Evans RM, Olefsky JM, Oh DY. Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. Diabetes. 2015 Apr; 64(4):1120-30. PMID: 25315009; PMCID: PMC4375077.
      4. Franck N, Maris M, Nalbandian S, Talukdar S, Schenk S, Hofmann HP, Bullough D, Osborn O. Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity. PLoS One. 2014; 9(9):e107487. PMID: 25244011; PMCID: PMC4171490.
      5. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2014 Sep 18; 513(7518):436-9. PMID: 25043058; PMCID: PMC4184286.
      6. Lee YS, Kim JW, Osborne O, Oh DY, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky JM. Increased adipocyte O2 consumption triggers HIF-1a, causing inflammation and insulin resistance in obesity. Cell. 2014 Jun 05; 157(6):1339-52. PMID: 24906151; PMCID: PMC4114226.
      7. Lu M, Sarruf DA, Li P, Osborn O, Sanchez-Alavez M, Talukdar S, Chen A, Bandyopadhyay G, Xu J, Morinaga H, Dines K, Watkins S, Kaiyala K, Schwartz MW, Olefsky JM. Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. J Biol Chem. 2013 Apr 12; 288(15):10722-35. PMID: 23457303; PMCID: PMC3624452.
      8. Osborn O, Oh DY, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, Li P, Thiede L, Morinaga H, Kim JJ, Heinrichsdorff J, Nalbandian S, Ofrecio JM, Scadeng M, Schenk S, Hadcock J, Bartfai T, Olefsky JM. G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest. 2012 Jul; 122(7):2444-53. PMID: 22653059; PMCID: PMC3386820.
      9. Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012 Mar 06; 18(3):363-74. PMID: 22395709.
        View in: PubMed
      10. Schenk S, McCurdy CE, Philp A, Chen MZ, Holliday MJ, Bandyopadhyay GK, Osborn O, Baar K, Olefsky JM. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest. 2011 Nov; 121(11):4281-8. PMID: 21985785; PMCID: PMC3204844.
      11. Talukdar S, Olefsky JM, Osborn O. Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends Pharmacol Sci. 2011 Sep; 32(9):543-50. PMID: 21663979; PMCID: PMC3419590.
      12. Sanchez-Alavez M, Osborn O, Tabarean IV, Holmberg KH, Eberwine J, Kahn CR, Bartfai T. Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. J Biol Chem. 2011 Apr 29; 286(17):14983-90. PMID: 21330367; PMCID: PMC3083203.
      13. Osborn O, Sanchez-Alavez M, Dubins JS, Gonzalez AS, Morrison B, Hadcock JR, Bartfai T. Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue. Cytokine. 2011 Mar; 53(3):311-9. PMID: 21177120; PMCID: PMC3033975.
      14. Osborn O, Sears DD, Olefsky JM. Fat-induced inflammation unchecked. Cell Metab. 2010 Dec 01; 12(6):553-4. PMID: 21109185.
        View in: PubMed
      15. Sanchez-Alavez M, Tabarean IV, Osborn O, Mitsukawa K, Schaefer J, Dubins J, Holmberg KH, Klein I, Klaus J, Gomez LF, Kolb H, Secrest J, Jochems J, Myashiro K, Buckley P, Hadcock JR, Eberwine J, Conti B, Bartfai T. Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons. Diabetes. 2010 Jan; 59(1):43-50. PMID: 19846801; PMCID: PMC2797943.
      16. Osborn O, Gram H, Zorrilla EP, Conti B, Bartfai T. Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. Swiss Med Wkly. 2008 Nov 15; 138(45-46):665-73. PMID: 18855149.
        View in: PubMed
      17. Reid E, Dearlove AM, Osborn O, Rogers MT, Rubinsztein DC. A locus for autosomal dominant "pure" hereditary spastic paraplegia maps to chromosome 19q13. Am J Hum Genet. 2000 Feb; 66(2):728-32. PMID: 10677333; PMCID: PMC1288126.
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