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    Nunzio Bottini

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0656
    CA La Jolla 92093
    Phone858-246-2398
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      Collapse Research 
      Collapse Research Activities and Funding
      Role of PTP4A1 in systemic sclerosis
      NIH/NIAMS R21AR069822Jul 15, 2016 - Jun 30, 2018
      Role: Principal Investigator
      Small Molecule Inhibitors of LMPTP: An Obesity Drug Target
      NIH/NIDDK R01DK106233Jul 1, 2015 - May 31, 2019
      Role: Principal Investigator
      Role of PTPRS in Rheumatoid Artiritis
      NIH/NIAMS R01AR066053Sep 1, 2014 - Aug 31, 2019
      Role: Principal Investigator
      Cell-based functional genetics of autoimmunity through targeted gene integration
      NIH/NIAID R21AI101875Feb 5, 2013 - Jan 31, 2016
      Role: Principal Investigator
      Small molecule inhibitors of LMPTP: an obesity drug target
      NIH/NIDA R03DA033986Feb 1, 2012 - Jan 31, 2014
      Role: Principal Investigator
      Fluorogenic Assays for Cell-based HTS of Tyrosine Phosphatase Inhibitors
      NIH/NIDDK R01DK080165Aug 15, 2008 - May 31, 2014
      Role: Principal Investigator
      Regulation of ZAP-70 by the Low Molecular Weight Protein Tyrosine Phosphatase
      NIH/NIAMS R03AR054053Sep 20, 2006 - Aug 31, 2010
      Role: Principal Investigator
      Lymphoid Tyrosine Phosphatase and Type I Diabetes
      NIH/NIAID R21AI065643Aug 1, 2006 - Jun 1, 2009
      Role: Principal Investigator
      PTPN22 AND AUTOIMMUNITY
      NIH/NIAID R01AI070544Jul 1, 2006 - Jan 31, 2020
      Role: Principal Investigator
      Fluorogenic PTP Assay for Use in HTS of Novel LYP Inhibitors
      NIH/NINDS R21NS056945Jul 1, 2006 - Jun 30, 2010
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Sacchetti C, Bottini N. Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets. Curr Rheumatol Rep. 2017 May; 19(5):28. PMID: 28397126.
        View in: PubMed
      2. Stanford SM, Bottini N. Targeting Tyrosine Phosphatases: Time to End the Stigma. Trends Pharmacol Sci. 2017 Jun; 38(6):524-540. PMID: 28412041.
        View in: PubMed
      3. Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 Jun; 13(6):624-632. PMID: 28346406.
        View in: PubMed
      4. Doody KM, Bottini N, Firestein GS. Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes. Epigenomics. 2017 Apr; 9(4):479-492. PMID: 28322585.
        View in: PubMed
      5. Cho JH, Kim HO, Ju YJ, Kye YC, Lee GW, Lee SW, Yun CH, Bottini N, Webster K, Goodnow CC, Surh CD, King C, Sprent J. CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells. Nat Commun. 2016 Nov 14; 7:13373. PMID: 27841348.
        View in: PubMed
      6. Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight. 2016 May 19; 1(7). PMID: 27275015.
        View in: PubMed
      7. Szodoray P, Stanford SM, Molberg Ø, Munthe LA, Bottini N, Nakken B. T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity. J Allergy Clin Immunol. 2016 Sep; 138(3):839-851.e8. PMID: 27056269.
        View in: PubMed
      8. Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N. Receptor Protein Tyrosine Phosphatase a-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice. Arthritis Rheumatol. 2016 Feb; 68(2):359-69. PMID: 26414708; PMCID: PMC4770259 [Available on 02/01/17].
      9. Bottini M, Bhattacharya K, Fadeel B, Magrini A, Bottini N, Rosato N. Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy. Nanomedicine. 2016 Feb; 12(2):255-68. PMID: 26707894.
        View in: PubMed
      10. Doody KM, Bottini N. Chondrocyte clocks make cartilage time-sensitive material. J Clin Invest. 2016 Jan; 126(1):38-9. PMID: 26657854; PMCID: PMC4701534 [Available on 01/04/17].
      11. Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA, Peterson LB, Bottini N, Wicker LS. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice. J Immunol. 2015 Nov 15; 195(10):4841-52. PMID: 26438525; PMCID: PMC4635565.
      12. Bottini N, Firestein GS. Decade in review-translational rheumatology: Ten years after: rheumatology research from bench to bedside. Nat Rev Rheumatol. 2015 Nov; 11(11):623-4. PMID: 26390844.
        View in: PubMed
      13. Wade F, Quijada P, Al-Haffar KM, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Zahid I, Al-Mohanna F, Stanford SM, Alvarez R, Liu Y, Colak D, Jordan MC, Roos KP, Assiri A, Al-Habeeb W, Sussman M, Bottini N, Poizat C. Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy. J Pathol. 2015 Dec; 237(4):482-94. PMID: 26213100.
        View in: PubMed
      14. Kiris E, Nuss JE, Stanford SM, Wanner LM, Cazares L, Maestre MF, Du HT, Gomba GY, Burnett JC, Gussio R, Bottini N, Panchal RG, Kane CD, Tessarollo L, Bavari S. Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays. PLoS One. 2015; 10(6):e0129264. PMID: 26061731; PMCID: PMC4462581.
      15. Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci Transl Med. 2015 May 20; 7(288):288ra76. PMID: 25995222; PMCID: PMC4458332.
      16. Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M. Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes. ACS Nano. 2014 Dec 23; 8(12):12280-91. PMID: 25415768; PMCID: PMC4373402.
      17. Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N. TGFß responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness. Ann Rheum Dis. 2016 Jan; 75(1):295-302. PMID: 25378349.
        View in: PubMed
      18. Fousteri G, Jofra T, Debernardis I, Stanford SM, Laurenzi A, Bottini N, Battaglia M. The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization. Clin Exp Immunol. 2014 Oct; 178(1):178-89. PMID: 24905474; PMCID: PMC4360206.
      19. de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, Eckmann L, Stanford SM, Bottini N, Corr M, Raz E. Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. J Clin Invest. 2014 Sep; 124(9):3793-806. PMID: 25083990; PMCID: PMC4151223.
      20. Doody KM, Bottini N. "PEST control": regulation of molecular barcodes by tyrosine phosphatases. Cell Res. 2014 Sep; 24(9):1027-8. PMID: 25081059; PMCID: PMC4152731.
      21. Stanford SM, Bottini N. PTPN22: the archetypal non-HLA autoimmunity gene. Nat Rev Rheumatol. 2014 Oct; 10(10):602-11. PMID: 25003765; PMCID: PMC4375551.
      22. Stanford SM, Ahmed V, Barrios AM, Bottini N. Cellular biochemistry methods for investigating protein tyrosine phosphatases. Antioxid Redox Signal. 2014 May 10; 20(14):2160-78. PMID: 24294920; PMCID: PMC3995294.
      23. Wu DJ, Zhou W, Enouz S, Orrú V, Stanford SM, Maine CJ, Rapini N, Sawatzke K, Engel I, Fiorillo E, Sherman LA, Kronenberg M, Zehn D, Peterson E, Bottini N. Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells. PLoS One. 2014; 9(2):e86677. PMID: 24498279; PMCID: PMC3911918.
      24. Ahmed VF, Bottini N, Barrios AM. Covalent inhibition of the lymphoid tyrosine phosphatase. ChemMedChem. 2014 Feb; 9(2):296-9. PMID: 24403103; PMCID: PMC4096870.
      25. Bottini M, Sacchetti C, Pietroiusti A, Bellucci S, Magrini A, Rosato N, Bottini N. Targeted nanodrugs for cancer therapy: prospects and challenges. J Nanosci Nanotechnol. 2014 Jan; 14(1):98-114. PMID: 24730253.
        View in: PubMed
      26. Bottini N, Peterson EJ. Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease. Annu Rev Immunol. 2014; 32:83-119. PMID: 24364806.
        View in: PubMed
      27. Bottini N, Firestein GS. Epigenetics in rheumatoid arthritis: a primer for rheumatologists. Curr Rheumatol Rep. 2013 Nov; 15(11):372. PMID: 24072602.
        View in: PubMed
      28. Kulkarni RA, Vellore NA, Bliss MR, Stanford SM, Falk MD, Bottini N, Baron R, Barrios AM. Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors. Chembiochem. 2013 Sep 02; 14(13):1640-7. PMID: 23956195; PMCID: PMC3874405.
      29. Stanford SM, Krishnamurthy D, Kulkarni RA, Karver CE, Bruenger E, Walker LM, Ma CT, Chung TD, Sergienko E, Bottini N, Barrios AM. pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays. Methods. 2014 Jan 15; 65(2):165-74. PMID: 23886911; PMCID: PMC3899110.
      30. Kulkarni RA, Stanford SM, Vellore NA, Krishnamurthy D, Bliss MR, Baron R, Bottini N, Barrios AM. Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase. ChemMedChem. 2013 Sep; 8(9):1561-8. PMID: 23873737; PMCID: PMC3863632.
      31. Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, Shaheen ZR, Cheng G, Sawatzke K, Campbell AM, Auger JL, Bilgic H, Shoyama FM, Schmeling DO, Balfour HH, Hasegawa K, Chan AC, Corbett JA, Binstadt BA, Mescher MF, Ley K, Bottini N, Peterson EJ. The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity. 2013 Jul 25; 39(1):111-22. PMID: 23871208; PMCID: PMC3830738.
      32. He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N, Cato AC, Zhang ZY. A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. J Med Chem. 2013 Jun 27; 56(12):4990-5008. PMID: 23713581; PMCID: PMC3711248.
      33. Sacchetti C, Rapini N, Magrini A, Cirelli E, Bellucci S, Mattei M, Rosato N, Bottini N, Bottini M. In vivo targeting of intratumor regulatory T cells using PEG-modified single-walled carbon nanotubes. Bioconjug Chem. 2013 Jun 19; 24(6):852-8. PMID: 23682992.
        View in: PubMed
      34. Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein GS, Bottini N. Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. Arthritis Rheum. 2013 May; 65(5):1171-80. PMID: 23335101; PMCID: PMC3636201.
      35. Sacchetti C, Motamedchaboki K, Magrini A, Palmieri G, Mattei M, Bernardini S, Rosato N, Bottini N, Bottini M. Surface polyethylene glycol conformation influences the protein corona of polyethylene glycol-modified single-walled carbon nanotubes: potential implications on biological performance. ACS Nano. 2013 Mar 26; 7(3):1974-89. PMID: 23413928.
        View in: PubMed
      36. Bottini N, Firestein GS. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat Rev Rheumatol. 2013 Jan; 9(1):24-33. PMID: 23147896; PMCID: PMC3970924.
      37. Stanford SM, Rapini N, Bottini N. Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. Immunology. 2012 Sep; 137(1):1-19. PMID: 22862552; PMCID: PMC3449242.
      38. Stanford SM, Panchal RG, Walker LM, Wu DJ, Falk MD, Mitra S, Damle SS, Ruble D, Kaltcheva T, Zhang S, Zhang ZY, Bavari S, Barrios AM, Bottini N. High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):13972-7. PMID: 22891353; PMCID: PMC3435192.
      39. Maine CJ, Hamilton-Williams EE, Cheung J, Stanford SM, Bottini N, Wicker LS, Sherman LA. PTPN22 alters the development of regulatory T cells in the thymus. J Immunol. 2012 Jun 01; 188(11):5267-75. PMID: 22539785; PMCID: PMC3358490.
      40. Teruel M, Martin JE, Ortego-Centeno N, Jiménez-Alonso J, Sánchez-Román J, de Ramón E, Gonzalez-Escribano MF, Pons-Estel BA, D'Alfonso S, Sebastiani GD, Witte T, Bottini N, González-Gay MA, Alarcón-Riquelme ME, Martin J. Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus. Hum Immunol. 2012 Jan; 73(1):107-10. PMID: 22064183.
        View in: PubMed
      41. Bottini M, Rosato N, Bottini N. PEG-modified carbon nanotubes in biomedicine: current status and challenges ahead. Biomacromolecules. 2011 Oct 10; 12(10):3381-93. PMID: 21916410.
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      42. Teruel M, Martin JE, González-Juanatey C, López-Mejias R, Miranda-Filloy JA, Blanco R, Balsa A, Pascual-Salcedo D, Rodriguez-Rodriguez L, Fernández-Gutierrez B, Ortiz AM, González-Alvaro I, Gómez-Vaquero C, Bottini N, Llorca J, González-Gay MA, Martin J. Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients. Arthritis Res Ther. 2011 Jul 18; 13(4):R116. PMID: 21767392; PMCID: PMC3239354.
      43. Stanford SM, Krishnamurthy D, Falk MD, Messina R, Debnath B, Li S, Liu T, Kazemi R, Dahl R, He Y, Yu X, Chan AC, Zhang ZY, Barrios AM, Woods VL, Neamati N, Bottini N. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem. 2011 Mar 24; 54(6):1640-54. PMID: 21341673; PMCID: PMC3086468.
      44. Rodríguez-Rodríguez L, Taib WR, Topless R, Steer S, González-Escribano MF, Balsa A, Pascual-Salcedo D, González-Gay MA, Raya E, Fernandez-Gutierrez B, González-Álvaro I, Bottini N, Witte T, Viken MK, Coenen MJ, van Riel PL, Franke B, den Heijer M, Radstake TR, Wordsworth P, Lie BA, Merriman TR, Martín J. The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples. Arthritis Rheum. 2011 Feb; 63(2):365-72. PMID: 21279993.
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      45. Diaz-Gallo LM, Espino-Paisán L, Fransen K, Gómez-García M, van Sommeren S, Cardeña C, Rodrigo L, Mendoza JL, Taxonera C, Nieto A, Alcain G, Cueto I, López-Nevot MA, Bottini N, Barclay ML, Crusius JB, van Bodegraven AA, Wijmenga C, Ponsioen CY, Gearry RB, Roberts RL, Weersma RK, Urcelay E, Merriman TR, Alizadeh BZ, Martin J. Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2011 Nov; 17(11):2287-94. PMID: 21287672.
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      46. Delogu LG, Stanford SM, Santelli E, Magrini A, Bergamaschi A, Motamedchaboki K, Rosato N, Mustelin T, Bottini N, Bottini M. Carbon nanotube-based nanocarriers: the importance of keeping it clean. J Nanosci Nanotechnol. 2010 Aug; 10(8):5293-301. PMID: 21125885.
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      47. Sebastiani GD, Bottini N, Greco E, Saccucci P, Canu G, Lucarelli P, Gloria-Bottini F, Fontana L. A study of Adenosine-Deaminase genetic polymorphism in rheumatoid arthritis. Int J Immunopathol Pharmacol. 2010 Jul-Sep; 23(3):791-5. PMID: 20943049.
        View in: PubMed
      48. Fiorillo E, Orrú V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N. Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue. J Biol Chem. 2010 Aug 20; 285(34):26506-18. PMID: 20538612; PMCID: PMC2924087.
      49. Stanford SM, Mustelin TM, Bottini N. Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases. Semin Immunopathol. 2010 Jun; 32(2):127-36. PMID: 20204370; PMCID: PMC2881161.
      50. Saccucci P, Meloni GF, Verrotti A, Borgiani P, D'Annibale F, Giannini C, Lucarelli P, Bottini N, Chiarelli F, Bottini E, Gloria-Bottini F. A study of three polymorphic sites of the ADA gene in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab. 2010 Mar; 23(3):283-90. PMID: 20480728.
        View in: PubMed
      51. Karver MR, Krishnamurthy D, Bottini N, Barrios AM. Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase. J Inorg Biochem. 2010 Mar; 104(3):268-73. PMID: 20083307; PMCID: PMC2873867.
      52. Steck AK, Baschal EE, Jasinski JM, Boehm BO, Bottini N, Concannon P, Julier C, Morahan G, Noble JA, Polychronakos C, She JX, Eisenbarth GS. rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype. Genes Immun. 2009 Dec; 10 Suppl 1:S21-6. PMID: 19956096; PMCID: PMC2805459.
      53. Karver MR, Krishnamurthy D, Kulkarni RA, Bottini N, Barrios AM. Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes. J Med Chem. 2009 Nov 12; 52(21):6912-8. PMID: 19888762; PMCID: PMC2801581.
      54. Saccucci P, Manca Bitti ML, Bottini N, Rapini N, Piccinini S, D'Annibale F, Chiarelli F, Verrotti A, Bottini E, Gloria-Bottini F. Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms. Med Sci Monit. 2009 Oct; 15(10):CR511-517. PMID: 19789510.
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      55. Liu Y, Stanford SM, Jog SP, Fiorillo E, Orrú V, Comai L, Bottini N. Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain. Biochemistry. 2009 Aug 11; 48(31):7525-32. PMID: 19586056; PMCID: PMC3113683.
      56. Shu YH, Hartiala J, Xiang AH, Trigo E, Lawrence JM, Allayee H, Buchanan TA, Bottini N, Watanabe RM. Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans. J Clin Endocrinol Metab. 2009 Oct; 94(10):4094-102. PMID: 19622628; PMCID: PMC2758733.
      57. Lamsyah H, Rueda B, Baassi L, Elaouad R, Bottini N, Sadki K, Martin J. Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population. Tissue Antigens. 2009 Sep; 74(3):228-32. PMID: 19563523.
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      58. Tsai SJ, Sen U, Zhao L, Greenleaf WB, Dasgupta J, Fiorillo E, Orrú V, Bottini N, Chen XS. Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation . Biochemistry. 2009 Jun 09; 48(22):4838-45. PMID: 19371084; PMCID: PMC2747803.
      59. Delogu LG, Magrini A, Bergamaschi A, Rosato N, Dawson MI, Bottini N, Bottini M. Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes. Bioconjug Chem. 2009 Mar 18; 20(3):427-31. PMID: 19243140.
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      60. Renzetti G, Silvestre G, D'Amario C, Bottini E, Gloria-Bottini F, Bottini N, Auais A, Perez MK, Piedimonte G. Less air pollution leads to rapid reduction of airway inflammation and improved airway function in asthmatic children. Pediatrics. 2009 Mar; 123(3):1051-8. PMID: 19255039.
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      61. Banci M, Saccucci P, D'Annibale F, Dofcaci A, Trionfera G, Magrini A, Bottini N, Bottini E, Gloria-Bottini F. ACP1 genetic polymorphism and coronary artery disease: an association study. Cardiology. 2009; 113(4):236-42. PMID: 19246900.
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      62. Orrú V, Tsai SJ, Rueda B, Fiorillo E, Stanford SM, Dasgupta J, Hartiala J, Zhao L, Ortego-Centeno N, D'Alfonso S, Arnett FC, Wu H, Gonzalez-Gay MA, Tsao BP, Pons-Estel B, Alarcon-Riquelme ME, He Y, Zhang ZY, Allayee H, Chen XS, Martin J, Bottini N. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Hum Mol Genet. 2009 Feb 01; 18(3):569-79. PMID: 18981062; PMCID: PMC2722189.
      63. Krishnamurthy D, Karver MR, Fiorillo E, Orrú V, Stanford SM, Bottini N, Barrios AM. Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study. J Med Chem. 2008 Aug 14; 51(15):4790-5. PMID: 18605719.
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      64. Banci M, Saccucci P, D'Annibale F, Dofcaci A, Trionfera G, Magrini A, Bottini N, Bottini E, Gloria-Bottini F. Adenosine deaminase genetic polymorphism and coronary artery disease. Cardiology. 2009; 112(1):74-5. PMID: 18560234.
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      65. Cato MH, D'Annibale F, Mills DM, Cerignoli F, Dawson MI, Bergamaschi E, Bottini N, Magrini A, Bergamaschi A, Rosato N, Rickert RC, Mustelin T, Bottini M. Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassemblies. J Nanosci Nanotechnol. 2008 May; 8(5):2259-69. PMID: 18572636.
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      66. Gloria-Bottini F, Bottini N, Magrini A, Renzetti G, Martinoli R, Bergamaschi A, Bottini E. Low birth weight and allergy: possible pleiotropic effect of ACP1. Hum Biol. 2008 Feb; 80(1):65-72. PMID: 18505045.
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      67. Saccucci P, Del Duca E, Rapini N, Verrotti A, Piccinini S, Maccari A, Canu G, Angelini F, Fontana L, Giannini C, Chiarelli F, Manca Bitti ML, Bottini N. Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy. Tissue Antigens. 2008 Mar; 71(3):234-7. PMID: 18179648.
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      68. Zoledziewska M, Perra C, Orrù V, Moi L, Frongia P, Congia M, Bottini N, Cucca F. Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes. Diabetes. 2008 Jan; 57(1):229-34. PMID: 17934143.
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      69. Vang T, Miletic AV, Bottini N, Mustelin T. Protein tyrosine phosphatase PTPN22 in human autoimmunity. Autoimmunity. 2007 Sep; 40(6):453-61. PMID: 17729039.
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      70. Greco E, Bottini N, Canu G, Maccari AM, Saccucci P, Gloria-Bottini F, Fontana L. Skin testing correlates negatively with high-activity ACP1 *B/*C genotype. Int Arch Allergy Immunol. 2008; 145(1):48-53. PMID: 17703100.
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      71. Gloria-Bottini F, Bottini N, La Torre M, Magrini A, Bergamaschi A, Bottini E. The effects of genetic and seasonal factors on reproductive success. Fertil Steril. 2008 May; 89(5):1090-4. PMID: 17678914.
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      72. Ammendola M, Bottini N, Pietropolli A, Saccucci P, Gloria-Bottini F. Association between PTPN22 and endometriosis. Fertil Steril. 2008 Apr; 89(4):993-4. PMID: 17624340.
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      73. Nicotra M, Bottini N, La Torre M, Amante A, Bottini E, Gloria-Bottini F. Repeated spontaneous abortion. Cooperative effects of ADA and ACP1 genetic polymorphisms. Am J Reprod Immunol. 2007 Jul; 58(1):1-10. PMID: 17565542.
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      74. Gloria-Bottini F, Bottini N, Renzetti G, Bottini E. ACP1 and Th class of immunological disease: evidence of interaction with gender. Int Arch Allergy Immunol. 2007; 143(3):170-6. PMID: 17284925.
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      75. Gloria-Bottini F, Meloni GF, Grassi S, Bottini N, Saccucci P, Giarrizzo GF, Magrini A, Bergamaschi A, Bottini E. ACP1 and offspring sex ratio in smoking puerperae: a study at population level. Early Hum Dev. 2007 Jun; 83(6):349-54. PMID: 16973312.
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      76. Gloria-Bottini F, Bottini N. The link between obesity and allergy: a role of ACP1 genetic polymorphism? Int J Obes (Lond). 2007 Feb; 31(2):392-3. PMID: 16770334.
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      77. Gloria-Bottini F, Meloni GF, Nicotra M, Saccucci P, Stampone L, Bottini N, Lista F, Bottini E. Feto-maternal ACP1 activity ratio and intrauterine survival. Eur J Obstet Gynecol Reprod Biol. 2008 Sep; 140(1):12-6. PMID: 16762482.
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      78. Gloria-Bottini F, Bottini N, Bottini E. Effect of ACP1*C on early life viability. Hum Biol. 2006 Jun; 78(3):365-9. PMID: 17216808.
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      79. Bottini N, Vang T, Cucca F, Mustelin T. Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Semin Immunol. 2006 Aug; 18(4):207-13. PMID: 16697661.
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      80. Liu Y, Saccucci P, Qi H, Wu HC, Zhao F, Dai Y, Bottini N, Gloria-Bottini F. ADA polymorphisms and asthma: a study in the Chinese Han population. J Asthma. 2006 Apr; 43(3):203-6. PMID: 16754522.
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      81. Nika K, Charvet C, Williams S, Tautz L, Bruckner S, Rahmouni S, Bottini N, Schoenberger SP, Baier G, Altman A, Mustelin T. Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation. Mol Cell Biol. 2006 Mar; 26(5):1806-16. PMID: 16479000; PMCID: PMC1430257.
      82. Gloria-Bottini F, Ronchetti F, Ammendola L, Bottini N. Adenosine deaminase polymorphism and the relationship of total immunoglobulin E with skin prick test: a study on school children. Allergy Asthma Proc. 2006 Mar-Apr; 27(2):115-8. PMID: 16724628.
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      83. Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med. 2005 Dec 05; 202(11):1587-97. PMID: 16330817; PMCID: PMC2213338.
      84. Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F, Mustelin T, Bottini N. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet. 2005 Dec; 37(12):1317-9. PMID: 16273109.
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      85. Gloria-Bottini F, Bottini N, Cosmi E, Cosmi EV, Bottini E. The effect of gender and ACP1 genetic polymorphism on the correlation between birth weight and placental weight. Placenta. 2005 Nov; 26(10):846-8. PMID: 16226135.
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      86. Bottini N, Gloria-Bottini F, Amante A, Saccucci P, Bottini E. Genetic polymorphism and TH1/TH2 orientation. Int Arch Allergy Immunol. 2005 Dec; 138(4):328-33. PMID: 16224193.
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      87. Bottini N, Stefanini L, Lucarelli P, Bottini E. Adaptation to past malarial endemia and susceptibility to common diseases in modern populations: a study of adenosine deaminase and MN blood group genetic polymorphisms. Am J Phys Anthropol. 2005 Sep; 128(1):194-8. PMID: 15761857.
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      88. Bottini M, Bruckner S, Nika K, Bottini N, Bellucci S, Magrini A, Bergamaschi A, Mustelin T. Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol Lett. 2006 Jan 05; 160(2):121-6. PMID: 16125885.
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      89. Wu H, Cantor RM, Graham DS, Lingren CM, Farwell L, Jager PL, Bottini N, Grossman JM, Wallace DJ, Hahn BH, Julkunen H, Hebert LA, Rovin BH, Birmingham DJ, Rioux JD, Yu CY, Kere J, Vyse TJ, Tsao BP. Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease. Arthritis Rheum. 2005 Aug; 52(8):2396-402. PMID: 16052563.
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      90. Iannaccone U, Bergamaschi A, Magrini A, Marino G, Bottini N, Lucarelli P, Bottini E, Gloria-Bottini F. Serum glucose concentration and ACP1 genotype in healthy adult subjects. Metabolism. 2005 Jul; 54(7):891-4. PMID: 15988697.
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      91. Musumeci L, Bongiorni C, Tautz L, Edwards RA, Osterman A, Perego M, Mustelin T, Bottini N. Low-molecular-weight protein tyrosine phosphatases of Bacillus subtilis. J Bacteriol. 2005 Jul; 187(14):4945-56. PMID: 15995210; PMCID: PMC1169535.
      92. Bottini N, Meloni GF, Lucarelli P, Amante A, Saccucci P, Gloria-Bottini F, Bottini E. Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACP1 and sex. Diabetes Metab Res Rev. 2005 Jul-Aug; 21(4):353-8. PMID: 15586390.
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      93. Mijakovic I, Musumeci L, Tautz L, Petranovic D, Edwards RA, Jensen PR, Mustelin T, Deutscher J, Bottini N. In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqE. J Bacteriol. 2005 May; 187(10):3384-90. PMID: 15866923; PMCID: PMC1112022.
      94. Bottini N, Ronchetti F, Gloria-Bottini F, Stefanini L, Bottini E, Lucarini N. Atopic and nonatopic asthma in children. J Asthma. 2005 Feb; 42(1):25-8. PMID: 15801324.
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      95. Ladner MB, Bottini N, Valdes AM, Noble JA. Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes. Hum Immunol. 2005 Jan; 66(1):60-4. PMID: 15620463.
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      96. Mijakovic I, Petranovic D, Bottini N, Deutscher J, Ruhdal Jensen P. Protein-tyrosine phosphorylation in Bacillus subtilis. J Mol Microbiol Biotechnol. 2005; 9(3-4):189-97. PMID: 16415592.
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      97. Mustelin T, Vang T, Bottini N. Protein tyrosine phosphatases and the immune response. Nat Rev Immunol. 2005 Jan; 5(1):43-57. PMID: 15630428.
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      98. Tautz L, Bruckner S, Sareth S, Alonso A, Bogetz J, Bottini N, Pellecchia M, Mustelin T. Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds. J Biol Chem. 2005 Mar 11; 280(10):9400-8. PMID: 15615724.
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      99. Bottini M, Tautz L, Huynh H, Monosov E, Bottini N, Dawson MI, Bellucci S, Mustelin T. Covalent decoration of multi-walled carbon nanotubes with silica nanoparticles. Chem Commun (Camb). 2005 Feb 14; (6):758-60. PMID: 15685328.
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      100. Saccucci P, Verdecchia M, Piciullo A, Bottini N, Rizzo R, Gloria-Bottini F, Lucarelli P, Curatolo P. Convulsive disorder and genetic polymorphism. Association of idiopathic generalized epilepsy with haptoglobin polymorphism. Neurogenetics. 2004 Dec; 5(4):245-8. PMID: 15490286.
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      101. Bottini N, Magrini A, Cosmi E, Gloria-Bottini F, Saccucci P, Di Iorio R, Bergamaschi A, Bottini E. Genetics of signal transduction and the effect of maternal smoking on sex ratio of offspring. Am J Hum Biol. 2004 Sep-Oct; 16(5):588-92. PMID: 15368606.
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      102. Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, Downey GP, Mustelin T. Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol. 2004 Sep; 6(9):831-9. PMID: 15322554.
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      103. Bottini N, Gloria-Bottini F, Borgiani P, Antonacci E, Lucarelli P, Bottini E. Type 2 diabetes and the genetics of signal transduction: a study of interaction between adenosine deaminase and acid phosphatase locus 1 polymorphisms. Metabolism. 2004 Aug; 53(8):995-1001. PMID: 15281007.
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      104. Mustelin T, Alonso A, Bottini N, Huynh H, Rahmouni S, Nika K, Louis-dit-Sully C, Tautz L, Togo SH, Bruckner S, Mena-Duran AV, al-Khouri AM. Protein tyrosine phosphatases in T cell physiology. Mol Immunol. 2004 Jul; 41(6-7):687-700. PMID: 15220004.
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      105. Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T. Protein tyrosine phosphatases in the human genome. Cell. 2004 Jun 11; 117(6):699-711. PMID: 15186772.
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      106. Bottini N, Gloria-Bottini F, Magrini A, Stefanini L, Cosmi E, Bergamaschi A, Cosmi EV, Bottini E. Maternal cigarette smoking, metabolic enzyme polymorphism, and developmental events in the early stages of extrauterine life. Hum Biol. 2004 Apr; 76(2):289-97. PMID: 15359537.
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      107. Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, MacMurray J, Meloni GF, Lucarelli P, Pellecchia M, Eisenbarth GS, Comings D, Mustelin T. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet. 2004 Apr; 36(4):337-8. PMID: 15004560.
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      108. Nika K, Hyunh H, Williams S, Paul S, Bottini N, Taskén K, Lombroso PJ, Mustelin T. Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location. Biochem J. 2004 Mar 01; 378(Pt 2):335-42. PMID: 14613483; PMCID: PMC1223964.
      109. Huynh H, Wang X, Li W, Bottini N, Williams S, Nika K, Ishihara H, Godzik A, Mustelin T. Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. J Immunol. 2003 Dec 15; 171(12):6661-71. PMID: 14662869.
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      110. Alonso A, Bottini N, Bruckner S, Rahmouni S, Williams S, Schoenberger SP, Mustelin T. Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH. J Biol Chem. 2004 Feb 06; 279(6):4922-8. PMID: 14623872.
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      111. Bottini M, Magrini A, Bottini N, Bergamaschi A. [Nanotubes and fullerenes: an overview of the possible environmental and biological impact of bio-nanotechnologies]. Med Lav. 2003 Nov-Dec; 94(6):497-505. PMID: 14768242.
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      112. Magrini A, Bottini N, Gloria-Bottini F, Stefanini L, Bergamaschi A, Cosmi E, Bottini E. Enzyme polymorphisms, smoking, and human reproduction. A study of human placental alkaline phosphatase. Am J Hum Biol. 2003 Nov-Dec; 15(6):781-5. PMID: 14595869.
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      113. Lucarelli P, Palminiello S, Saccucci P, Bottini N, De Luca D, Elia M, Fiumara A, Curatolo P. Association study of autistic disorder and chromosome 16p. Am J Med Genet A. 2003 Jun 01; 119A(2):242-6. PMID: 12749074.
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      114. Meloni G, Bottini N, Borgiani P, Lucarelli P, Meloni T, Bottini E. Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes. Med Sci Monit. 2003 Mar; 9(3):CR105-8. PMID: 12640337.
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      115. Bottini N, Otsu A, Borgiani P, Saccucci P, Stefanini L, Greco E, Fontana L, Hopkins JM, Mao XQ. Genetic control of serum IgE levels: a study of low molecular weight protein tyrosine phosphatase. Clin Genet. 2003 Mar; 63(3):228-31. PMID: 12694235.
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      116. Mustelin T, Rahmouni S, Bottini N, Alonso A. Role of protein tyrosine phosphatases in T cell activation. Immunol Rev. 2003 Feb; 191:139-47. PMID: 12614357.
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      117. Magrini A, Bottini N, Nicotra M, Cosmi E, Bottini E, Bergamaschi A. Smoking and the genetics of signal transduction: an association study on retinopathy in type 1 diabetes. Am J Med Sci. 2002 Dec; 324(6):310-3. PMID: 12495297.
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      118. Bottini N, Ronchetti F, Gloria-Bottini F. Cooperative effect of adenosine deaminase and ABO-secretor genetic complex on susceptibility to childhood asthma. Eur Respir J. 2002 Dec; 20(6):1613-5. PMID: 12503725.
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      119. Bottini N, Saccucci P, Piciullo A, Iannetti P, Lucarini N, Lucarelli P, Gloria-Bottini F, Curatolo P. Convulsive disorder and the genetics of signal transduction; a study of a low molecular weight protein tyrosine phosphatase in a pediatric sample. Neurosci Lett. 2002 Nov 29; 333(3):159-62. PMID: 12429372.
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      120. Bottini N, MacMurray J, Peters W, Rostamkhani M, Comings DE. Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women. Mol Genet Metab. 2002 Nov; 77(3):226-9. PMID: 12409270.
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      121. Bottini N, MacMurray J, Rostamkani M, McGue M, Iacono WG, Comings DE. Association between the low molecular weight cytosolic acid phosphatase gene ACP1*A and comorbid features of Tourette syndrome. Neurosci Lett. 2002 Sep 20; 330(2):198-200. PMID: 12231445.
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      122. Faggioni G, Borgiani P, Bottini N, Gloria-Bottini F, Tontoli F, Contreas V, Bottini E, Lista F. Identification of two SNPs in the 5' flanking region of the ACP1 gene and evaluation of disequilibrium among polymorphic sites. Ann Hum Genet. 2002 Jul; 66(Pt 4):245-54. PMID: 12418966.
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      123. Birle D, Bottini N, Williams S, Huynh H, deBelle I, Adamson E, Mustelin T. Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. J Immunol. 2002 Jul 01; 169(1):286-91. PMID: 12077256.
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      124. Bottini N, Ammendola M, Gloria-Bottini F. ACP1 is associated with allergy. Allergy. 2002 Jul; 57(7):651-2. PMID: 12100313.
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      125. Bottini N, Stefanini L, Williams S, Alonso A, Jascur T, Abraham RT, Couture C, Mustelin T. Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). J Biol Chem. 2002 Jul 05; 277(27):24220-4. PMID: 11976341.
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      126. Bottini N, Meloni GF, Borgiani P, Giorgini A, Buzzetti R, Pozzilli P, Lucarelli P, Gloria-Bottini F. Genotypes of cytosolic low-molecular-weight protein-tyrosine-phosphatase correlate with age at onset of type 1 diabetes in a sex-specific manner. Metabolism. 2002 Apr; 51(4):419-22. PMID: 11912546.
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      127. Lucarelli P, Saccucci P, Bottini N, De Luca D, Fiumara A, Elia M, Bottini N, Porfirio MC, Curatolo P. Two-loci ADA haplotypes in autistic disorder. Am J Med Genet. 2002 Apr 01; 108(4):339-40. PMID: 11920843.
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      128. Bottini N, Borgiani P, Otsu A, Saccucci P, Stefanini L, Greco E, Fontana L, Hopkin JM, Mao XQ, Shirakawa T. IL-4 receptor alpha chain genetic polymorphism and total IgE levels in the English population: two-locus haplotypes are more informative than individual SNPs. Clin Genet. 2002 Apr; 61(4):288-92. PMID: 12030894.
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      129. Bottini N, Magrini A, Macmurray J, Cosmi E, Nicotra M, Gloria-Bottini F, Bergamaschi A. Smoking, haptoglobin and fertility in humans. Tob Induc Dis. 2002 Jan 15; 1(1):3-6. PMID: 19570244; PMCID: PMC2671529.
      130. Bottini N, Mao XQ, Borgiani P, Saccucci P, Stefanini L, Greco E, Fontana L, Shirakawa T, Hopkin JM. Low molecular weight PTP-IL-4RA interaction in atopy predisposition. Allergy. 2002; 57 Suppl 72:10-2. PMID: 12144546.
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      131. Bottini N, Bottini E, Gloria-Bottini F, Mustelin T. Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms. Arch Immunol Ther Exp (Warsz). 2002; 50(2):95-104. PMID: 12022706.
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      132. Mustelin T, Feng GS, Bottini N, Alonso A, Kholod N, Birle D, Merlo J, Huynh H. Protein tyrosine phosphatases. Front Biosci. 2002 Jan 01; 7:d85-142. PMID: 11779706.
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      133. Bottini E, Palmarino R, Lucarelli P, Lista F, Bottini N. ACP1 and human adaptability: association with past malarial morbidity in the Sardinian population. Am J Hum Biol. 2001 Nov-Dec; 13(6):753-60. PMID: 11748814.
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      134. Bottini E, Lucarini N, Amante A, Bottini N, Faggioni G. The genetics of signal transduction and the outcome of diagnostic tests in growth retardation. J Endocrinol. 2001 Nov; 171(2):267-71. PMID: 11691646.
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      135. Ronchetti F, Villa MP, Ronchetti R, Bonci E, Latini L, Pascone R, Bottini N, Gloria-Bottini F. ABO/Secretor genetic complex and susceptibility to asthma in childhood. Eur Respir J. 2001 Jun; 17(6):1236-8. PMID: 11491170.
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      136. Bottini N, Meloni GF, Finocchi A, Ruggiu G, Amante A, Meloni T, Bottini E. Maternal-fetal interaction in the ABO system: a comparative analysis of healthy mothers and couples with recurrent spontaneous abortion suggests a protective effect of B incompatibility. Hum Biol. 2001 Apr; 73(2):167-74. PMID: 11446422.
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      137. Bottini N, De Luca D, Saccucci P, Fiumara A, Elia M, Porfirio MC, Lucarelli P, Curatolo P. Autism: evidence of association with adenosine deaminase genetic polymorphism. Neurogenetics. 2001 Mar; 3(2):111-3. PMID: 11354825.
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      138. Greene LS, Bottini N, Borgiani P, Gloria-Bottini F. Acid phosphatase locus 1 (ACP1): Possible relationship of allelic variation to body size and human population adaptation to thermal stress-A theoretical perspective. Am J Hum Biol. 2000 Sep; 12(5):688-701. PMID: 11534062.
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      139. Bottini N, Ronchetti F, Villa MP. MN blood groups and asthma onset. Lancet. 2000 Aug 05; 356(9228):506. PMID: 10981912.
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      140. Gao PS, Fujishima S, Mao XQ, Remus N, Kanda M, Enomoto T, Dake Y, Bottini N, Tabuchi M, Hasegawa N, Yamaguchi K, Tiemessen C, Hopkin JM, Shirakawa T, Kishi F. Genetic variants of NRAMP1 and active tuberculosis in Japanese populations. International Tuberculosis Genetics Team. Clin Genet. 2000 Jul; 58(1):74-6. PMID: 10945666.
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      141. Gloria-Bottini F, Antonacci E, Bottini N, Ogana A, Borgiani P, De Santis G, Lucarini N. RH blood groups and diabetic disorders: is there an effect on glycosylated hemoglobin level? Hum Biol. 2000 Apr; 72(2):287-94. PMID: 10803660.
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      142. Bottini N, Gloria-Bottini F, Lucarini N, Ronchetti PG, Fontana L. Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase. Dis Markers. 2000; 16(3-4):163-6. PMID: 11381200; PMCID: PMC3851624.
      143. Bottini N, Lucarini N, Nicotra M, Gloria-Bottini F. A marker locus for fertility?-- Real or spurious? Fertil Steril. 1999 Dec; 72(6):1148-9. PMID: 10593401.
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      144. Bottini N, Fontana L. Asthma and diabetes. Lancet. 1999 Aug 07; 354(9177):515-6. PMID: 10465205.
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      145. Bottini N, Gimelfarb A, Gloria-Bottini F, La Torre M, Lucarelli P, Lucarini N. Haptoglobin genotype and natural fertility in humans. Fertil Steril. 1999 Aug; 72(2):293-6. PMID: 10438998.
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      146. Bottini N, Ronchetti MP, Gloria-Bottini F, Fontana L. Malaria as a possible evolutionary cause of allergy. Allergy. 1999 Feb; 54(2):188-9. PMID: 10221447.
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      147. Bottini E, Cosmi E, Nicotra M, Santeusanio G, La Torre M, Bottini N, Lucarini N. The genetics of signal transduction and the feto-maternal relationship. A study of cytosolic low molecular weight phosphotyrosine phosphatase. Dis Markers. 1998 Nov; 14(3):143-50. PMID: 10427472; PMCID: PMC3850845.
      148. Lucarini N, Antonacci E, Bottini N, Borgiani P, Faggioni G, Gloria-Bottini F. Phosphotyrosine-protein-phosphatase and diabetic disorders. Further studies on the relationship between low molecular weight acid phosphatase genotype and degree of glycemic control. Dis Markers. 1998 Oct; 14(2):121-5. PMID: 9868599; PMCID: PMC3850866.
      149. Nicotra M, Bottini N, Grasso M, Gimelfarb A, Lucarini N, Cosmi E, Bottini E. Adenosine deaminase and human reproduction: a comparative study of fertile women and women with recurrent spontaneous abortion. Am J Reprod Immunol. 1998 Apr; 39(4):266-70. PMID: 9553651.
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      150. Lucarini N, Bottini N, Antonacci E, Borgiani P, Faggioni G, Gloria-Bottini F. Diabetic complications and the genetics of signal transduction. A study of retinopathy in NIDDM. Dis Markers. 1997 Nov; 13(3):169-76. PMID: 9405929.
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      151. Lucarini N, Antonacci E, Bottini N, Gloria Bottini F. Low-molecular-weight acid phosphatase (ACP1), obesity, and blood lipid levels in subjects with non-insulin-dependent diabetes mellitus. Hum Biol. 1997 Aug; 69(4):509-15. PMID: 9198310.
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