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    Nicholas Schork

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentFamily Medicine and Public Health
    Address9500 Gilman Drive #0603
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Integrative Resource to Develop Translational Strategies to Promote Longevity
      NIH/NIA U24AG051129Sep 15, 2015 - May 31, 2020
      Role: Principal Investigator
      The Bipolar Genome Study
      NIH/NIMH R01MH094483Jul 1, 2012 - Apr 30, 2015
      Role: Principal Investigator
      Functional genomic tools for in vivo study of P. vivax
      NIH/NIAID R21AI085374Jun 15, 2010 - Nov 30, 2012
      Role: Principal Investigator
      Biomarkers of Autism at 12 months: From Brain Overgrowth to Genes
      NIH/NIMH P50MH081755Aug 6, 2007 - Jun 30, 2014
      Role: Co-Investigator
      Genomics for Transplantation: Discovery and Biomarkers
      NIH U19AI063603Sep 1, 2004 - Aug 31, 2016
      Role: Co-Investigator
      FAMILY BLOOD PRESSURE PROGRAM
      NIH/NHLBI U01HL064777Sep 29, 2000 - Jun 30, 2005
      Role: Principal Investigator
      Sympathetic Neuroeffector Junctions &Blood Pressure
      NIH P01HL058120Jun 1, 1999 - May 31, 2012
      Role: Co-Investigator
      High Performance Computing for Biomedical Research
      NIH P41RR006009Sep 1, 1990 - Jul 31, 2013
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Caussy C, Soni M, Cui J, Bettencourt R, Schork N, Chen CH, Ikhwan MA, Bassirian S, Cepin S, Gonzalez MP, Mendler M, Kono Y, Vodkin I, Mekeel K, Haldorson J, Hemming A, Andrews B, Salotti J, Richards L, Brenner DA, Sirlin CB, Loomba R. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. J Clin Invest. 2017 Jun 30; 127(7):2697-2704. PMID: 28628033.
        View in: PubMed
      2. Buckley AR, Standish KA, Bhutani K, Ideker T, Lasken RS, Carter H, Harismendy O, Schork N. Pan-cancer analysis reveals technical artifacts in TCGA germline variant calls. BMC Genomics. 2017 Jun 12; 18(1):458. PMID: 28606096.
        View in: PubMed
      3. Standish KA, Huang CC, Curran ME, Schork N. Comprehensive analysis of treatment response phenotypes in rheumatoid arthritis for pharmacogenetic studies. Arthritis Res Ther. 2017 May 12; 19(1):90. PMID: 28494788.
        View in: PubMed
      4. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metab. 2017 May 02; 25(5):1054-1062.e5. PMID: 28467925.
        View in: PubMed
      5. Long T, Hicks M, Yu HC, Biggs WH, Kirkness EF, Menni C, Zierer J, Small KS, Mangino M, Messier H, Brewerton S, Turpaz Y, Perkins BA, Evans AM, Miller LA, Guo L, Caskey CT, Schork N, Garner C, Spector TD, Venter JC, Telenti A. Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites. Nat Genet. 2017 Apr; 49(4):568-578. PMID: 28263315.
        View in: PubMed
      6. Li Q, Wineinger NE, Fu DJ, Libiger O, Alphs L, Savitz A, Gopal S, Cohen N, Schork N. Genome-wide association study of paliperidone efficacy. Pharmacogenet Genomics. 2017 Jan; 27(1):7-18. PMID: 27846195.
        View in: PubMed
      7. Yin X, Wineinger NE, Wang K, Yue W, Norgren N, Wang L, Yao W, Jiang X, Wu B, Cui Y, Shen C, Cheng H, Zhou F, Chen G, Zuo X, Zheng X, Fan X, Wang H, Wang L, Lee J, Lam M, Tai ES, Zhang Z, Huang Q, Sun L, Xu J, Yang S, Wilhelmsen KC, Liu J, Schork N, Zhang X. Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population. J Psychiatry Neurosci. 2016 Oct; 41(6):413-421. PMID: 27091718.
        View in: PubMed
      8. Kawakatsu T, Huang SC, Jupe F, Sasaki E, Schmitz RJ, Urich MA, Castanon R, Nery JR, Barragan C, He Y, Chen H, Dubin M, Lee CR, Wang C, Bemm F, Becker C, O'Neil R, O'Malley RC, Quarless DX, Schork N, Weigel D, Nordborg M, Ecker JR. Epigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions. Cell. 2016 Jul 14; 166(2):492-505. PMID: 27419873.
        View in: PubMed
      9. Bhutani K, Nazor KL, Williams R, Tran H, Dai H, Džakula Ž, Cho EH, Pang AW, Rao M, Cao H, Schork N, Loring JF. Whole-genome mutational burden analysis of three pluripotency induction methods. Nat Commun. 2016 Feb 19; 7:10536. PMID: 26892726; PMCID: PMC4762882.
      10. Libiger O, Schork N. Partial Least Squares Regression Can Aid in Detecting Differential Abundance of Multiple Features in Sets of Metagenomic Samples. Front Genet. 2015; 6:350. PMID: 26734061; PMCID: PMC4681790.
      11. Coombes B, Basu S, Guha S, Schork N. Weighted Score Tests Implementing Model-Averaging Schemes in Detection of Rare Variants in Case-Control Studies. PLoS One. 2015; 10(10):e0139355. PMID: 26436424; PMCID: PMC4593572.
      12. Standish KA, Carland TM, Lockwood GK, Pfeiffer W, Tatineni M, Huang CC, Lamberth S, Cherkas Y, Brodmerkel C, Jaeger E, Smith L, Rajagopal G, Curran ME, Schork N. Group-based variant calling leveraging next-generation supercomputing for large-scale whole-genome sequencing studies. BMC Bioinformatics. 2015 Sep 22; 16:304. PMID: 26395405; PMCID: PMC4580299.
      13. Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Dec; 149(7):1784-93. PMID: 26299412; PMCID: PMC4663110 [Available on 12/01/16].
      14. Chen CH, Peng Q, Schork AJ, Lo MT, Fan CC, Wang Y, Desikan RS, Bettella F, Hagler DJ, Westlye LT, Kremen WS, Jernigan TL, Le Hellard S, Steen VM, Espeseth T, Huentelman M, Håberg AK, Agartz I, Djurovic S, Andreassen OA, Schork N, Dale AM. Large-scale genomics unveil polygenic architecture of human cortical surface area. Nat Commun. 2015 Jul 20; 6:7549. PMID: 26189703; PMCID: PMC4518289.
      15. Newman E, Thompson WK, Bartsch H, Hagler DJ, Chen CH, Brown TT, Kuperman JM, McCabe C, Chung Y, Libiger O, Akshoomoff N, Bloss CS, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Kennedy DN, Murray SS, Sowell ER, Schork N, Kenet T, Kaufmann WE, Mostofsky S, Amaral DG, Dale AM, Jernigan TL. Anxiety is related to indices of cortical maturation in typically developing children and adolescents. Brain Struct Funct. 2016 Jul; 221(6):3013-25. PMID: 26183468.
        View in: PubMed
      16. Fan CC, Bartsch H, Schork AJ, Chen CH, Wang Y, Lo MT, Brown TT, Kuperman JM, Hagler DJ, Schork N, Jernigan TL, Dale AM. Modeling the 3D geometry of the cortical surface with genetic ancestry. Curr Biol. 2015 Aug 03; 25(15):1988-92. PMID: 26166778; PMCID: PMC4786069.
      17. Yin X, Cheng H, Lin Y, Wineinger NE, Zhou F, Sheng Y, Yang C, Li P, Li F, Shen C, Yang S, Schork N, Zhang X. A weighted polygenic risk score using 14 known susceptibility variants to estimate risk and age onset of psoriasis in Han Chinese. PLoS One. 2015; 10(5):e0125369. PMID: 25933357; PMCID: PMC4416725.
      18. Jernigan TL, Brown TT, Hagler DJ, Akshoomoff N, Bartsch H, Newman E, Thompson WK, Bloss CS, Murray SS, Schork N, Kennedy DN, Kuperman JM, McCabe C, Chung Y, Libiger O, Maddox M, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Sowell ER, Kenet T, Kaufmann WE, Mostofsky S, Amaral DG, Dale AM. The Pediatric Imaging, Neurocognition, and Genetics (PING) Data Repository. Neuroimage. 2016 Jan 01; 124(Pt B):1149-54. PMID: 25937488; PMCID: PMC4628902 [Available on 01/01/17].
      19. Schork N. Personalized medicine: Time for one-person trials. Nature. 2015 Apr 30; 520(7549):609-11. PMID: 25925459.
        View in: PubMed
      20. Norden-Krichmar TM, Gizer IR, Wilhelmsen KC, Schork N, Ehlers CL. Protective variant associated with alcohol dependence in a Mexican American cohort. BMC Med Genet. 2014 Dec 21; 15:136. PMID: 25527893; PMCID: PMC4337107.
      21. Peng Q, Gizer IR, Libiger O, Bizon C, Wilhelmsen KC, Schork N, Ehlers CL. Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample. Am J Med Genet B Neuropsychiatr Genet. 2014 Dec; 165B(8):673-83. PMID: 25270064; PMCID: PMC4364382.
      22. Clarke TK, Crist RC, Doyle GA, Weiss AR, Brandt H, Crawford S, Crow S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB, Keel P, Klump KL, Lilenfeld L, Plotnicov K, Magistretti PJ, Bergen AW, Kaye WH, Schork N, Berrettini WH. Characterization of genetic variation in the VGLL4 gene in anorexia nervosa. Psychiatr Genet. 2014 Aug; 24(4):183-4. PMID: 24983835; PMCID: PMC4104366.
      23. Bright AT, Manary MJ, Tewhey R, Arango EM, Wang T, Schork N, Yanow SK, Winzeler EA. A high resolution case study of a patient with recurrent Plasmodium vivax infections shows that relapses were caused by meiotic siblings. PLoS Negl Trop Dis. 2014 Jun; 8(6):e2882. PMID: 24901334; PMCID: PMC4046966.
      24. Rana BK, Darst BF, Bloss C, Shih PA, Depp C, Nievergelt CM, Allison M, Parsons JK, Schork N, Jeste DV. Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults. Am J Geriatr Psychiatry. 2014 Oct; 22(10):997-1006.e5. PMID: 24791650; PMCID: PMC4163500.
      25. Norden-Krichmar TM, Gizer IR, Libiger O, Wilhelmsen KC, Ehlers CL, Schork N. Correlation analysis of genetic admixture and social identification with body mass index in a Native American community. Am J Hum Biol. 2014 May-Jun; 26(3):347-60. PMID: 24757035; PMCID: PMC4068510.
      26. Nievergelt CM, Wineinger NE, Libiger O, Pham P, Zhang G, Baker DG, Schork N. Chip-based direct genotyping of coding variants in genome wide association studies: utility, issues and prospects. Gene. 2014 Apr 25; 540(1):104-9. PMID: 24521671; PMCID: PMC3980715.
      27. Zhang K, Huentelman MJ, Rao F, Sun EI, Corneveaux JJ, Schork AJ, Wei Z, Waalen J, Miramontes-Gonzalez JP, Hightower CM, Maihofer AX, Mahata M, Pastinen T, Ehret GB, Schork N, Eskin E, Nievergelt CM, Saier MH, O'Connor DT. Genetic implication of a novel thiamine transporter in human hypertension. J Am Coll Cardiol. 2014 Apr 22; 63(15):1542-55. PMID: 24509276; PMCID: PMC3992204.
      28. Peng Q, Schork N. Utility of network integrity methods in therapeutic target identification. Front Genet. 2014; 5:12. PMID: 24550933; PMCID: PMC3909879.
      29. Yurgil KA, Barkauskas DA, Vasterling JJ, Nievergelt CM, Larson GE, Schork N, Litz BT, Nash WP, Baker DG. Association between traumatic brain injury and risk of posttraumatic stress disorder in active-duty Marines. JAMA Psychiatry. 2014 Feb; 71(2):149-57. PMID: 24337530.
        View in: PubMed
      30. Bloss CS, Schork N, Topol EJ. Direct-to-consumer pharmacogenomic testing is associated with increased physician utilisation. J Med Genet. 2014 Feb; 51(2):83-9. PMID: 24343916.
        View in: PubMed
      31. Zhang K, Deacon DC, Rao F, Schork AJ, Fung MM, Waalen J, Schork N, Nievergelt CM, Chi NC, O'Connor DT. Human heart rate: heritability of resting and stress values in twin pairs, and influence of genetic variation in the adrenergic pathway at a microribonucleic acid (microrna) motif in the 3'-UTR of cytochrome b561 [corrected]. J Am Coll Cardiol. 2014 Feb 04; 63(4):358-68. PMID: 24140660; PMCID: PMC3946708.
      32. Franceschini N, Fox E, Zhang Z, Edwards TL, Nalls MA, Sung YJ, Tayo BO, Sun YV, Gottesman O, Adeyemo A, Johnson AD, Young JH, Rice K, Duan Q, Chen F, Li Y, Tang H, Fornage M, Keene KL, Andrews JS, Smith JA, Faul JD, Guangfa Z, Guo W, Liu Y, Murray SS, Musani SK, Srinivasan S, Velez Edwards DR, Wang H, Becker LC, Bovet P, Bochud M, Broeckel U, Burnier M, Carty C, Chasman DI, Ehret G, Chen WM, Chen G, Chen W, Ding J, Dreisbach AW, Evans MK, Guo X, Garcia ME, Jensen R, Keller MF, Lettre G, Lotay V, Martin LW, Moore JH, Morrison AC, Mosley TH, Ogunniyi A, Palmas W, Papanicolaou G, Penman A, Polak JF, Ridker PM, Salako B, Singleton AB, Shriner D, Taylor KD, Vasan R, Wiggins K, Williams SM, Yanek LR, Zhao W, Zonderman AB, Becker DM, Berenson G, Boerwinkle E, Bottinger E, Cushman M, Eaton C, Nyberg F, Heiss G, Hirschhron JN, Howard VJ, Karczewsk KJ, Lanktree MB, Liu K, Liu Y, Loos R, Margolis K, Snyder M, Psaty BM, Schork N, Weir DR, Rotimi CN, Sale MM, Harris T, Kardia SL, Hunt SC, Arnett D, Redline S, Cooper RS, Risch NJ, Rao DC, Rotter JI, Chakravarti A, Reiner AP, Levy D, Keating BJ, Zhu X. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet. 2013 Sep 05; 93(3):545-54. PMID: 23972371; PMCID: PMC3769920.
      33. Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayés M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DH, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisén L, Gallagher L, Gejman PV, Georgieva L, Gershon ES, Geschwind DH, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green EK, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan W, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath AC, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holmans PA, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kähler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim Y, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landén M, Långström N, Lathrop M, Lawrence J, Lawson WB, Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, MacIntyre DJ, Madden PA, Maestrini E, Magnusson PK, Mahon PB, Maier W, Malhotra AK, Mane SM, Martin CL, Martin NG, Mattheisen M, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough JJ, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon WM, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp CM, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Mühleisen TW, Muir WJ, Müller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nöthen MM, Nurnberger JI, Nwulia EA, Nyholt DR, O'Dushlaine C, Oades RD, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson AD, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Posthuma D, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga JA, Rasmussen HB, Raychaudhuri S, Rehnström K, Reif A, Ribasés M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rossin L, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders AR, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner WA, Schellenberg GD, Scherer SW, Schork N, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi J, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith EN, Sonuga-Barke EJ, St Clair D, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier J, Stroup TS, Sutcliffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov AA, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Van Os J, Vicente AM, Vieland VJ, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker TF, Wijsman EM, Willemsen G, Williams N, et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013 Sep; 45(9):984-94. PMID: 23933821; PMCID: PMC3800159.
      34. Schork N. Genetic parts to a preventive medicine whole. Genome Med. 2013; 5(6):54. PMID: 23806045; PMCID: PMC3706981.
      35. Wineinger NE, Harper A, Libiger O, Srinivasan SR, Chen W, Berenson GS, Schork N. Genomic risk models improve prediction of longitudinal lipid levels in children and young adults. Front Genet. 2013; 4:86. PMID: 23734161; PMCID: PMC3659298.
      36. Friese RS, Altshuler AE, Zhang K, Miramontes-Gonzalez JP, Hightower CM, Jirout ML, Salem RM, Gayen JR, Mahapatra NR, Biswas N, Cale M, Vaingankar SM, Kim HS, Courel M, Taupenot L, Ziegler MG, Schork N, Pravenec M, Mahata SK, Schmid-Schönbein GW, O'Connor DT. MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension. Hum Mol Genet. 2013 Sep 15; 22(18):3624-40. PMID: 23674521; PMCID: PMC3749858.
      37. Greenwood TA, Swerdlow NR, Gur RE, Cadenhead KS, Calkins ME, Dobie DJ, Freedman R, Green MF, Gur RC, Lazzeroni LC, Nuechterlein KH, Olincy A, Radant AD, Ray A, Schork N, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Light GA, Braff DL. Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia. Am J Psychiatry. 2013 May; 170(5):521-32. PMID: 23511790; PMCID: PMC3878873.
      38. Schork AJ, Thompson WK, Pham P, Torkamani A, Roddey JC, Sullivan PF, Kelsoe JR, O'Donovan MC, Furberg H, Schork N, Andreassen OA, Dale AM. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet. 2013 Apr; 9(4):e1003449. PMID: 23637621; PMCID: PMC3636284.
      39. Bloss CS, Wineinger NE, Darst BF, Schork N, Topol EJ. Impact of direct-to-consumer genomic testing at long term follow-up. J Med Genet. 2013 Jun; 50(6):393-400. PMID: 23559530.
        View in: PubMed
      40. Libiger O, Schork N. A Method for Inferring an Individual's Genetic Ancestry and Degree of Admixture Associated with Six Major Continental Populations. Front Genet. 2012; 3:322. PMID: 23335941; PMCID: PMC3543981.
      41. Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Franceschini N, Gaunt TR, Gho JM, Gieger C, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MF, Mellander O, Molony CM, Nolte IM, Padmanabhan S, Price TS, Rajagopalan R, Shaffer J, Shah S, Shen H, Soranzo N, van der Most PJ, Van Iperen EP, Van Setten J, Van Setten JA, Vonk JM, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Boer JM, Boerwinkle E, Burkley B, Burt A, Chakravarti A, Chen W, Cooper-Dehoff RM, Curtis SP, Dreisbach A, Duggan D, Ehret GB, Fabsitz RR, Fornage M, Fox E, Furlong CE, Gansevoort RT, Hofker MH, Hovingh GK, Kirkland SA, Kottke-Marchant K, Kutlar A, Lacroix AZ, Langaee TY, Li YR, Lin H, Liu K, Maiwald S, Malik R, Murugesan G, Newton-Cheh C, O'Connell JR, Onland-Moret NC, Ouwehand WH, Palmas W, Penninx BW, Pepine CJ, Pettinger M, Polak JF, Ramachandran VS, Ranchalis J, Redline S, Ridker PM, Rose LM, Scharnag H, Schork N, Shimbo D, Shuldiner AR, Srinivasan SR, Stolk RP, Taylor HA, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Winkelmann BR, Wyatt S, Young JH, Boehm BO, Caulfield MJ, Chasman DI, Davidson KW, Doevendans PA, Fitzgerald GA, Gums JG, Hakonarson H, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJ, Koenig W, März W, Mitchell BD, Murray SS, Oldehinkel AJ, Rader DJ, Reilly MP, Reiner AP, Schadt EE, Silverstein RL, Snieder H, Stanton AV, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Johnson AD, Munroe PB, de Bakker PI, Zhu X, Levy D, Keating BJ, Asselbergs FW. Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet. 2013 Apr 15; 22(8):1663-78. PMID: 23303523; PMCID: PMC3657476.
      42. Bailer UF, Frank GK, Price JC, Meltzer CC, Becker C, Mathis CA, Wagner A, Barbarich-Marsteller NC, Bloss CS, Putnam K, Schork N, Gamst A, Kaye WH. Interaction between serotonin transporter and dopamine D2/D3 receptor radioligand measures is associated with harm avoidant symptoms in anorexia and bulimia nervosa. Psychiatry Res. 2013 Feb 28; 211(2):160-8. PMID: 23154100; PMCID: PMC3880148.
      43. Torkamani A, Pham P, Libiger O, Bansal V, Zhang G, Scott-Van Zeeland AA, Tewhey R, Topol EJ, Schork N. Clinical implications of human population differences in genome-wide rates of functional genotypes. Front Genet. 2012; 3:211. PMID: 23125845; PMCID: PMC3485509.
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      45. Nissen S, Liang S, Shehktman T, Kelsoe JR, Greenwood TA, Nievergelt CM, McKinney R, Shilling PD, Smith EN, Schork N, Bloss CS, Nurnberger JI, Edenberg HJ, Foroud T, Koller DL, Gershon ES, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon FJ, Berrettini WH, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Schulze TG. Evidence for association of bipolar disorder to haplotypes in the 22q12.3 region near the genes stargazin, IFT27 and parvalbumin. Am J Med Genet B Neuropsychiatr Genet. 2012 Dec; 159B(8):941-50. PMID: 23038240; PMCID: PMC3665332.
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      47. Zapala MA, Schork N. Statistical properties of multivariate distance matrix regression for high-dimensional data analysis. Front Genet. 2012; 3:190. PMID: 23060897; PMCID: PMC3461701.
      48. Zhang K, Rao F, Miramontes-Gonzalez JP, Hightower CM, Vaught B, Chen Y, Greenwood TA, Schork AJ, Wang L, Mahata M, Stridsberg M, Khandrika S, Biswas N, Fung MM, Waalen J, Middelberg RP, Heath AC, Montgomery GW, Martin NG, Whitfield JB, Baker DG, Schork N, Nievergelt CM, O'Connor DT. Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses. J Am Coll Cardiol. 2012 Oct 23; 60(17):1678-89. PMID: 23021333; PMCID: PMC3687554.
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      50. Meier S, Mattheisen M, Vassos E, Strohmaier J, Treutlein J, Josef F, Breuer R, Degenhardt F, Mühleisen TW, Müller-Myhsok B, Steffens M, Schmael C, McMahon FJ, Nöthen MM, Cichon S, Schulze TG, Rietschel M, Kelsoe JR, Greenwood TA, Nievergelt CM, Barrett TB, McKinney R, Shilling PD, Schork N, Smith EN, Bloss CS, Nurnberger J, Edenberg HJ, Foroud T, Koller DL, Gershon ES, Liu CY, Badner JA, Scheftner W, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Chen DT, Schulze TG, Berrettini W, Potash JB, Zandi PP, Mahon PB, McInnis M, Craig D, Szelinger S. Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1. Transl Psychiatry. 2012 Sep 25; 2:e165. PMID: 23010768; PMCID: PMC3565205.
      51. Bright AT, Tewhey R, Abeles S, Chuquiyauri R, Llanos-Cuentas A, Ferreira MU, Schork N, Vinetz JM, Winzeler EA. Whole genome sequencing analysis of Plasmodium vivax using whole genome capture. BMC Genomics. 2012 Jun 21; 13:262. PMID: 22721170; PMCID: PMC3410760.
      52. Baker DG, Nash WP, Litz BT, Geyer MA, Risbrough VB, Nievergelt CM, O'Connor DT, Larson GE, Schork N, Vasterling JJ, Hammer PS, Webb-Murphy JA. Predictors of risk and resilience for posttraumatic stress disorder among ground combat Marines: methods of the Marine Resiliency Study. Prev Chronic Dis. 2012; 9:E97. PMID: 22575082; PMCID: PMC3431952.
      53. Chow ML, Pramparo T, Winn ME, Barnes CC, Li HR, Weiss L, Fan JB, Murray S, April C, Belinson H, Fu XD, Wynshaw-Boris A, Schork N, Courchesne E. Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages. PLoS Genet. 2012; 8(3):e1002592. PMID: 22457638; PMCID: PMC3310790.
      54. Damani S, Bacconi A, Libiger O, Chourasia AH, Serry R, Gollapudi R, Goldberg R, Rapeport K, Haaser S, Topol S, Knowlton S, Bethel K, Kuhn P, Wood M, Carragher B, Schork N, Jiang J, Rao C, Connelly M, Fowler VM, Topol EJ. Characterization of circulating endothelial cells in acute myocardial infarction. Sci Transl Med. 2012 Mar 21; 4(126):126ra33. PMID: 22440735; PMCID: PMC3589570.
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      61. Winn ME, Shaw M, April C, Klotzle B, Fan JB, Murray SS, Schork N. Gene expression profiling of human whole blood samples with the Illumina WG-DASL assay. BMC Genomics. 2011 Aug 15; 12:412. PMID: 21843359; PMCID: PMC3175478.
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      63. Bakken TE, Bloss CS, Roddey JC, Joyner AH, Rimol LM, Djurovic S, Melle I, Sundet K, Agartz I, Andreassen OA, Dale AM, Schork N. Association of genetic variants on 15q12 with cortical thickness and cognition in schizophrenia. Arch Gen Psychiatry. 2011 Aug; 68(8):781-90. PMID: 21810643; PMCID: PMC3375053.
      64. Bloss CS, Berrettini W, Bergen AW, Magistretti P, Duvvuri V, Strober M, Brandt H, Crawford S, Crow S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, Keel P, Klump KL, Mitchell J, Treasure J, Woodside DB, Marzola E, Schork N, Kaye WH. Genetic association of recovery from eating disorders: the role of GABA receptor SNPs. Neuropsychopharmacology. 2011 Oct; 36(11):2222-32. PMID: 21750581; PMCID: PMC3176559.
      65. Smith EN, Koller DL, Panganiban C, Szelinger S, Zhang P, Badner JA, Barrett TB, Berrettini WH, Bloss CS, Byerley W, Coryell W, Edenberg HJ, Foroud T, Gershon ES, Greenwood TA, Guo Y, Hipolito M, Keating BJ, Lawson WB, Liu C, Mahon PB, McInnis MG, McMahon FJ, McKinney R, Murray SS, Nievergelt CM, Nurnberger JI, Nwulia EA, Potash JB, Rice J, Schulze TG, Scheftner WA, Shilling PD, Zandi PP, Zöllner S, Craig DW, Schork N, Kelsoe JR. Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. PLoS Genet. 2011 Jun; 7(6):e1002134. PMID: 21738484; PMCID: PMC3128104.
      66. Fung MM, Salem RM, Lipkowitz MS, Bhatnagar V, Pandey B, Schork N, O'Connor DT. Methylenetetrahydrofolate reductase (MTHFR) polymorphism A1298C (Glu429Ala) predicts decline in renal function over time in the African-American Study of Kidney Disease and Hypertension (AASK) Trial and Veterans Affairs Hypertension Cohort (VAHC). Nephrol Dial Transplant. 2012 Jan; 27(1):197-205. PMID: 21613384; PMCID: PMC3350339.
      67. Degner SC, Verma-Gaur J, Wong TP, Bossen C, Iverson GM, Torkamani A, Vettermann C, Lin YC, Ju Z, Schulz D, Murre CS, Birshtein BK, Schork N, Schlissel MS, Riblet R, Murre C, Feeney AJ. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9566-71. PMID: 21606361; PMCID: PMC3111298.
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      71. Stone WS, Giuliano AJ, Tsuang MT, Braff DL, Cadenhead KS, Calkins ME, Dobie DJ, Faraone SV, Freedman R, Green MF, Greenwood TA, Gur RE, Gur RC, Light GA, Mintz J, Nuechterlein KH, Olincy A, Radant AD, Roe AH, Schork N, Siever LJ, Silverman JM, Swerdlow NR, Thomas AR, Tsuang DW, Turetsky BI, Seidman LJ. Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia (COGS). Schizophr Res. 2011 May; 128(1-3):102-10. PMID: 21288694.
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      72. Topol EJ, Schork N, Smith JM. Digital medicine and the Scripps Translational Science Institute. Clin Transl Sci. 2011 Feb; 4(1):8-9. PMID: 21348949.
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      74. Bansal V, Libiger O, Torkamani A, Schork N. An application and empirical comparison of statistical analysis methods for associating rare variants to a complex phenotype. Pac Symp Biocomput. 2011; 76-87. PMID: 21121035; PMCID: PMC5017238.
      75. Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou C, Boer Ad, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, Meyer NJ, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszewski M, Tomaszweski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmuda JM, Clarke R, Balmforth AJ, Danesh J, Day IN, Schork N, de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, Christie JD, Berenson GS, Murray SS, Illig T, Dorn GW, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, März W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ, Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT, Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet. 2011 Jan 07; 88(1):6-18. PMID: 21194676; PMCID: PMC3014369.
      76. Bloss CS, Jeste DV, Schork N. Genomics for disease treatment and prevention. Psychiatr Clin North Am. 2011 Mar; 34(1):147-66. PMID: 21333845; PMCID: PMC3073546.
      77. Salem RM, Pandey B, Richard E, Fung MM, Garcia EP, Brophy VH, Schork N, O'Connor DT, Bhatnagar V. The VA Hypertension Primary Care Longitudinal Cohort: Electronic medical records in the post-genomic era. Health Informatics J. 2010 Dec; 16(4):274-86. PMID: 21216807; PMCID: PMC3099595.
      78. McLachlan S, Lee SM, Steele TM, Hawthorne PL, Zapala MA, Eskin E, Schork N, Anderson GJ, Vulpe CD. In silico QTL mapping of basal liver iron levels in inbred mouse strains. Physiol Genomics. 2011 Feb 11; 43(3):136-47. PMID: 21062905; PMCID: PMC3055709.
      79. Bhatia G, Bansal V, Harismendy O, Schork N, Topol EJ, Frazer K, Bafna V. A covering method for detecting genetic associations between rare variants and common phenotypes. PLoS Comput Biol. 2010 Oct 14; 6(10):e1000954. PMID: 20976246; PMCID: PMC2954823.
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      81. Bloss CS, Ornowski L, Silver E, Cargill M, Vanier V, Schork N, Topol EJ. Consumer perceptions of direct-to-consumer personalized genomic risk assessments. Genet Med. 2010 Sep; 12(9):556-66. PMID: 20717041.
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      82. Bloss CS, Pawlikowska L, Schork N. Contemporary human genetic strategies in aging research. Ageing Res Rev. 2011 Apr; 10(2):191-200. PMID: 20709627; PMCID: PMC3043164.
      83. Winn ME, Zapala MA, Hovatta I, Risbrough VB, Lillie E, Schork N. The effects of globin on microarray-based gene expression analysis of mouse blood. Mamm Genome. 2010 Jun; 21(5-6):268-75. PMID: 20473674; PMCID: PMC2890980.
      84. Olincy A, Braff DL, Adler LE, Cadenhead KS, Calkins ME, Dobie DJ, Green MF, Greenwood TA, Gur RE, Gur RC, Light GA, Mintz J, Nuechterlein KH, Radant AD, Schork N, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Wagner BD, Freedman R. Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia. Schizophr Res. 2010 Jun; 119(1-3):175-82. PMID: 20382002; PMCID: PMC3688282.
      85. Radant AD, Dobie DJ, Calkins ME, Olincy A, Braff DL, Cadenhead KS, Freedman R, Green MF, Greenwood TA, Gur RE, Gur RC, Light GA, Meichle SP, Millard SP, Mintz J, Nuechterlein KH, Schork N, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang MT, Turetsky BI, Tsuang DW. Antisaccade performance in schizophrenia patients, their first-degree biological relatives, and community comparison subjects: data from the COGS study. Psychophysiology. 2010 Sep; 47(5):846-56. PMID: 20374545; PMCID: PMC4176871.
      86. Schumann CM, Bloss CS, Barnes CC, Wideman GM, Carper RA, Akshoomoff N, Pierce K, Hagler D, Schork N, Lord C, Courchesne E. Longitudinal magnetic resonance imaging study of cortical development through early childhood in autism. J Neurosci. 2010 Mar 24; 30(12):4419-27. PMID: 20335478; PMCID: PMC2859218.
      87. Torkamani A, Dean B, Schork N, Thomas EA. Coexpression network analysis of neural tissue reveals perturbations in developmental processes in schizophrenia. Genome Res. 2010 Apr; 20(4):403-12. PMID: 20197298; PMCID: PMC2847743.
      88. Schork N, Topol EJ. Genotype-based risk and pharmacogenetic sampling in clinical trials. J Biopharm Stat. 2010 Mar; 20(2):315-33. PMID: 20309761; PMCID: PMC2892229.
      89. Bansal V, Harismendy O, Tewhey R, Murray SS, Schork N, Topol EJ, Frazer KA. Accurate detection and genotyping of SNPs utilizing population sequencing data. Genome Res. 2010 Apr; 20(4):537-45. PMID: 20150320; PMCID: PMC2847757.
      90. Joo EJ, Greenwood TA, Schork N, McKinney RA, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Kelsoe JR. Suggestive evidence for linkage of ADHD features in bipolar disorder to chromosome 10p14. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 05; 153B(1):260-8. PMID: 19603423.
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      91. Chen Y, Wen G, Rao F, Zhang K, Wang L, Rodriguez-Flores JL, Sanchez AP, Mahata M, Taupenot L, Sun P, Mahata SK, Tayo B, Schork N, Ziegler MG, Hamilton BA, O'Connor DT. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure. J Hypertens. 2010 Jan; 28(1):76-86. PMID: 20009769; PMCID: PMC2860271.
      92. Schork N, Bansal V. Not so lost in the genetic crowd. Nat Genet. 2009 Nov; 41(11):1163-4. PMID: 19862007.
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      93. Fung MM, Chen Y, Lipkowitz MS, Salem RM, Bhatnagar V, Mahata M, Nievergelt CM, Rao F, Mahata SK, Schork N, Brophy VH, O'Connor DT. Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. Nephrol Dial Transplant. 2009 Dec; 24(12):3677-86. PMID: 19745105; PMCID: PMC2790952.
      94. Joyner AH, J CR, Bloss CS, Bakken TE, Rimol LM, Melle I, Agartz I, Djurovic S, Topol EJ, Schork N, Andreassen OA, Dale AM. A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations. Proc Natl Acad Sci U S A. 2009 Sep 08; 106(36):15483-8. PMID: 19717458; PMCID: PMC2741277.
      95. Rana BK, Wessel J, Mahboubi V, Rao F, Haeller J, Gayen JR, Eskin E, Valle AM, Das M, Mahata SK, Taupenot L, Stridsberg M, Talley TT, Ziegler MG, Smith DW, Schork N, O'Connor DT, Taylor P. Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs. J Pharmacol Exp Ther. 2009 Nov; 331(2):419-28. PMID: 19671882; PMCID: PMC2775266.
      96. Libiger O, Nievergelt CM, Schork N. Comparison of genetic distance measures using human SNP genotype data. Hum Biol. 2009 Aug; 81(4):389-406. PMID: 20067366.
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      97. Torkamani A, Schork N. Identification of rare cancer driver mutations by network reconstruction. Genome Res. 2009 Sep; 19(9):1570-8. PMID: 19574499; PMCID: PMC2752121.
      98. Torkamani A, Schork N. Prestige centrality-based functional outlier detection in gene expression analysis. Bioinformatics. 2009 Sep 01; 25(17):2222-8. PMID: 19549629; PMCID: PMC2800353.
      99. Schork N, Murray SS, Frazer KA, Topol EJ. Common vs. rare allele hypotheses for complex diseases. Curr Opin Genet Dev. 2009 Jun; 19(3):212-9. PMID: 19481926; PMCID: PMC2914559.
      100. Frazer KA, Murray SS, Schork N, Topol EJ. Human genetic variation and its contribution to complex traits. Nat Rev Genet. 2009 Apr; 10(4):241-51. PMID: 19293820.
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      101. Harismendy O, Ng PC, Strausberg RL, Wang X, Stockwell TB, Beeson KY, Schork N, Murray SS, Topol EJ, Levy S, Frazer KA. Evaluation of next generation sequencing platforms for population targeted sequencing studies. Genome Biol. 2009; 10(3):R32. PMID: 19327155; PMCID: PMC2691003.
      102. Zhang K, Rao F, Rana BK, Gayen JR, Calegari F, King A, Rosa P, Huttner WB, Stridsberg M, Mahata M, Vaingankar S, Mahboubi V, Salem RM, Rodriguez-Flores JL, Fung MM, Smith DW, Schork N, Ziegler MG, Taupenot L, Mahata SK, O'Connor DT. Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B. Circ Cardiovasc Genet. 2009 Feb; 2(1):46-56. PMID: 20011129.
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      103. Schwimmer JB, Celedon MA, Lavine JE, Salem R, Campbell N, Schork N, Shiehmorteza M, Yokoo T, Chavez A, Middleton MS, Sirlin CB. Heritability of nonalcoholic fatty liver disease. Gastroenterology. 2009 May; 136(5):1585-92. PMID: 19208353; PMCID: PMC3397140.
      104. Torkamani A, Schork N. Pathway and network analysis with high-density allelic association data. Methods Mol Biol. 2009; 563:289-301. PMID: 19597792.
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      105. Bhatnagar V, O'Connor DT, Brophy VH, Schork N, Richard E, Salem RM, Nievergelt CM, Bakris GL, Middleton JP, Norris KC, Wright J, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS. G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions. Am J Hypertens. 2009 Mar; 22(3):332-8. PMID: 19119263; PMCID: PMC2715837.
      106. Torkamani A, Verkhivker G, Schork N. Cancer driver mutations in protein kinase genes. Cancer Lett. 2009 Aug 28; 281(2):117-27. PMID: 19081671; PMCID: PMC2905872.
      107. Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork N, Taupenot L, Ziegler MG, O'Connor DT. Adrenergic polymorphism and the human stress response. Ann N Y Acad Sci. 2008 Dec; 1148:282-96. PMID: 19120120; PMCID: PMC2743085.
      108. Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar SM, Wen G, Salem RM, Das M, Cockburn MG, Schork N, Ziegler MG, Hamilton BA, Mahata SK, Taupenot L, O'Connor DT. Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. J Am Coll Cardiol. 2008 Oct 28; 52(18):1468-81. PMID: 19017515; PMCID: PMC2659417.
      109. Zhou D, Xue J, Lai JC, Schork N, White KP, Haddad GG. Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. PLoS Genet. 2008 Oct; 4(10):e1000221. PMID: 18927626; PMCID: PMC2556400.
      110. Torkamani A, Topol EJ, Schork N. Pathway analysis of seven common diseases assessed by genome-wide association. Genomics. 2008 Nov; 92(5):265-72. PMID: 18722519; PMCID: PMC2602835.
      111. Mathews CA, Greenwood T, Wessel J, Azzam A, Garrido H, Chavira DA, Chandavarkar U, Bagnarello M, Stein M, Schork N. Evidence for a heritable unidimensional symptom factor underlying obsessionality. Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 05; 147B(6):676-85. PMID: 18163383.
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      112. Turetsky BI, Greenwood TA, Olincy A, Radant AD, Braff DL, Cadenhead KS, Dobie DJ, Freedman R, Green MF, Gur RE, Gur RC, Light GA, Mintz J, Nuechterlein KH, Schork N, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Calkins ME. Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands. Biol Psychiatry. 2008 Dec 15; 64(12):1051-9. PMID: 18701089; PMCID: PMC2653714.
      113. Torkamani A, Kannan N, Taylor SS, Schork N. Congenital disease SNPs target lineage specific structural elements in protein kinases. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):9011-6. PMID: 18579784; PMCID: PMC2449356.
      114. Torkamani A, Schork N. Predicting functional regulatory polymorphisms. Bioinformatics. 2008 Aug 15; 24(16):1787-92. PMID: 18562267; PMCID: PMC2732211.
      115. Sivagnanam M, Mueller JL, Lee H, Chen Z, Nelson SF, Turner D, Zlotkin SH, Pencharz PB, Ngan BY, Libiger O, Schork N, Lavine JE, Taylor S, Newbury RO, Kolodner RD, Hoffman HM. Identification of EpCAM as the gene for congenital tufting enteropathy. Gastroenterology. 2008 Aug; 135(2):429-37. PMID: 18572020; PMCID: PMC2574708.
      116. Horan WP, Braff DL, Nuechterlein KH, Sugar CA, Cadenhead KS, Calkins ME, Dobie DJ, Freedman R, Greenwood TA, Gur RE, Gur RC, Light GA, Mintz J, Olincy A, Radant AD, Schork N, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Green MF. Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia. Schizophr Res. 2008 Aug; 103(1-3):218-28. PMID: 18406578; PMCID: PMC2529172.
      117. Evans LM, Akiskal HS, Greenwood TA, Nievergelt CM, Keck PE, McElroy SL, Sadovnick AD, Remick RA, Schork N, Kelsoe JR. Suggestive linkage of a chromosomal locus on 18p11 to cyclothymic temperament in bipolar disorder families. Am J Med Genet B Neuropsychiatr Genet. 2008 Apr 05; 147(3):326-32. PMID: 18081158.
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      118. Torkamani A, Schork N. Prediction of cancer driver mutations in protein kinases. Cancer Res. 2008 Mar 15; 68(6):1675-82. PMID: 18339846.
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      119. Braff DL, Greenwood TA, Swerdlow NR, Light GA, Schork N. Advances in endophenotyping schizophrenia. World Psychiatry. 2008 Feb; 7(1):11-8. PMID: 18458787; PMCID: PMC2359727.
      120. Malo N, Libiger O, Schork N. Accommodating linkage disequilibrium in genetic-association analyses via ridge regression. Am J Hum Genet. 2008 Feb; 82(2):375-85. PMID: 18252218; PMCID: PMC2427310.
      121. Salem RM, Cadman PE, Chen Y, Rao F, Wen G, Hamilton BA, Rana BK, Smith DW, Stridsberg M, Ward HJ, Mahata M, Mahata SK, Bowden DW, Hicks PJ, Freedman BI, Schork N, O'Connor DT. Chromogranin A polymorphisms are associated with hypertensive renal disease. J Am Soc Nephrol. 2008 Mar; 19(3):600-14. PMID: 18235090; PMCID: PMC2391050.
      122. Fung MM, Nguyen C, Mehtani P, Salem RM, Perez B, Thomas B, Das M, Schork N, Mahata SK, Ziegler MG, O'Connor DT. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. Circulation. 2008 Jan 29; 117(4):517-25. PMID: 18180394; PMCID: PMC2628716.
      123. Schork N, Wessel J, Malo N. DNA sequence-based phenotypic association analysis. Adv Genet. 2008; 60:195-217. PMID: 18358322.
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      124. Zhou D, Wang J, Zapala MA, Xue J, Schork N, Haddad GG. Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death. Physiol Genomics. 2008 Feb 19; 32(3):370-9. PMID: 18056785.
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      125. Barrett TB, Emberton JE, Nievergelt CM, Liang SG, Hauger RL, Eskin E, Schork N, Kelsoe JR. Further evidence for association of GRK3 to bipolar disorder suggests a second disease mutation. Psychiatr Genet. 2007 Dec; 17(6):315-22. PMID: 18075471.
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      126. Greenwood TA, Braff DL, Light GA, Cadenhead KS, Calkins ME, Dobie DJ, Freedman R, Green MF, Gur RE, Gur RC, Mintz J, Nuechterlein KH, Olincy A, Radant AD, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Schork N. Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia. Arch Gen Psychiatry. 2007 Nov; 64(11):1242-50. PMID: 17984393.
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      127. Wessel J, Schork AJ, Tiwari HK, Schork N. Powerful designs for genetic association studies that consider twins and sibling pairs with discordant genotypes. Genet Epidemiol. 2007 Nov; 31(7):789-96. PMID: 17549743.
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      128. Bhatnagar V, O'Connor DT, Schork N, Salem RM, Nievergelt CM, Rana BK, Smith DW, Bakris GL, Middleton JP, Norris KC, Wright JT, Cheek D, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS. Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial. J Hypertens. 2007 Oct; 25(10):2082-92. PMID: 17885551; PMCID: PMC2792638.
      129. Torkamani A, Schork N. Accurate prediction of deleterious protein kinase polymorphisms. Bioinformatics. 2007 Nov 01; 23(21):2918-25. PMID: 17855419.
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      130. Zhang L, Rao F, Zhang K, Khandrika S, Das M, Vaingankar SM, Bao X, Rana BK, Smith DW, Wessel J, Salem RM, Rodriguez-Flores JL, Mahata SK, Schork N, Ziegler MG, O'Connor DT. Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk. J Clin Invest. 2007 Sep; 117(9):2658-71. PMID: 17717598; PMCID: PMC1950457.
      131. Mosley CA, Taupenot L, Biswas N, Taulane JP, Olson NH, Vaingankar SM, Wen G, Schork N, Ziegler MG, Mahata SK, O'Connor DT. Biogenesis of the secretory granule: chromogranin A coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation. Biochemistry. 2007 Sep 25; 46(38):10999-1012. PMID: 17718510.
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      132. Libiger O, Schork N. A simulation-based analysis of chromosome segment sharing among a group of arbitrarily related individuals. Eur J Hum Genet. 2007 Dec; 15(12):1260-8. PMID: 17700628.
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      133. Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork N, Taupenot L, Ziegler MG, O'Connor DT. Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo. Circulation. 2007 Aug 28; 116(9):993-1006. PMID: 17698732.
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      134. Knöll R, Postel R, Wang J, Krätzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Kube D, Knöll G, Schäfer K, Hayashi T, Holm T, Kimura A, Schork N, Toliat MR, Nürnberg P, Schultheiss HP, Schaper W, Schaper J, Bos E, Den Hertog J, van Eeden FJ, Peters PJ, Hasenfuss G, Chien KR, Bakkers J. Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation. 2007 Jul 31; 116(5):515-25. PMID: 17646580.
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      135. Wen G, Wessel J, Zhou W, Ehret GB, Rao F, Stridsberg M, Mahata SK, Gent PM, Das M, Cooper RS, Chakravarti A, Zhou H, Schork N, O'connor DT, Hamilton BA. An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension. Hum Mol Genet. 2007 Jul 15; 16(14):1752-64. PMID: 17584765; PMCID: PMC2695823.
      136. Torkamani A, Schork N. Distribution analysis of nonsynonymous polymorphisms within the human kinase gene family. Genomics. 2007 Jul; 90(1):49-58. PMID: 17498919.
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      137. Wessel J, Zapala MA, Schork N. Accommodating pathway information in expression quantitative trait locus analysis. Genomics. 2007 Jul; 90(1):132-42. PMID: 17493783.
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      138. Braff D, Schork N, Gottesman II. Endophenotyping schizophrenia. Am J Psychiatry. 2007 May; 164(5):705-7. PMID: 17475726.
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      139. Stein MB, Schork N, Gelernter J. Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders. Neuropsychopharmacology. 2008 Jan; 33(2):312-9. PMID: 17460615.
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      140. Lillie EO, Mahata M, Khandrika S, Rao F, Bundey RA, Wen G, Chen Y, Taupenot L, Smith DW, Mahata SK, Ziegler MG, Cockburn M, Schork N, O'Connor DT. Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function. Circulation. 2007 May 01; 115(17):2282-91. PMID: 17438153.
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      141. Rao F, Wen G, Gayen JR, Das M, Vaingankar SM, Rana BK, Mahata M, Kennedy BP, Salem RM, Stridsberg M, Abel K, Smith DW, Eskin E, Schork N, Hamilton BA, Ziegler MG, Mahata SK, O'Connor DT. Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension. Circulation. 2007 May 01; 115(17):2271-81. PMID: 17438154.
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      142. Gong Y, Beitelshees AL, Wessel J, Langaee TY, Schork N, Johnson JA. Single nucleotide polymorphism discovery and haplotype analysis of Ca2+-dependent K+ channel beta-1 subunit. Pharmacogenet Genomics. 2007 Apr; 17(4):267-75. PMID: 17496725; PMCID: PMC2713575.
      143. Greenwood TA, Libiger O, Kardia S, Hanis C, Morrison AC, Gu CC, Rice T, Miller M, Turner ST, Myers RH, Grove J, Hsiao CF, Weder AB, Schork N. Comprehensive linkage and linkage heterogeneity analysis of 4344 sibling pairs affected with hypertension from the Family Blood Pressure Program. Genet Epidemiol. 2007 Apr; 31(3):195-210. PMID: 17266112.
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      144. Rao F, Wessel J, Wen G, Zhang L, Rana BK, Kennedy BP, Greenwood TA, Salem RM, Chen Y, Khandrika S, Hamilton BA, Smith DW, Holstein-Rathlou NH, Ziegler MG, Schork N, O'Connor DT. Renal albumin excretion: twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism. Hypertension. 2007 May; 49(5):1015-31. PMID: 17353515.
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      145. Swerdlow NR, Sprock J, Light GA, Cadenhead K, Calkins ME, Dobie DJ, Freedman R, Green MF, Greenwood TA, Gur RE, Mintz J, Olincy A, Nuechterlein KH, Radant AD, Schork N, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Tsuang DW, Tsuang MT, Turetsky BI, Braff DL. Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia. Schizophr Res. 2007 May; 92(1-3):237-51. PMID: 17346930; PMCID: PMC2039885.
      146. Nievergelt CM, Libiger O, Schork N. Generalized analysis of molecular variance. PLoS Genet. 2007 Apr 06; 3(4):e51. PMID: 17411342; PMCID: PMC1847693.
      147. Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih PA, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum JL, Schork N, Schmid-Schönbein GW, O'Connor DT. C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 2007 Feb; 25(2):329-43. PMID: 17211240.
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      148. Glatt SJ, Chayavichitsilp P, Depp C, Schork N, Jeste DV. Successful aging: from phenotype to genotype. Biol Psychiatry. 2007 Aug 15; 62(4):282-93. PMID: 17210144.
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      149. Hovatta I, Zapala MA, Broide RS, Schadt EE, Libiger O, Schork N, Lockhart DJ, Barlow C. DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies. Genome Biol. 2007; 8(2):R25. PMID: 17324278; PMCID: PMC1852412.
      150. Rana BK, Insel PA, Payne SH, Abel K, Beutler E, Ziegler MG, Schork N, O'Connor DT. Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Hypertension. 2007 Jan; 49(1):96-106. PMID: 17159089.
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      151. Zapala MA, Schork N. Multivariate regression analysis of distance matrices for testing associations between gene expression patterns and related variables. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19430-5. PMID: 17146048; PMCID: PMC1748243.
      152. Braff DL, Freedman R, Schork N, Gottesman II. Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull. 2007 Jan; 33(1):21-32. PMID: 17088422; PMCID: PMC2632293.
      153. Calkins ME, Dobie DJ, Cadenhead KS, Olincy A, Freedman R, Green MF, Greenwood TA, Gur RE, Gur RC, Light GA, Mintz J, Nuechterlein KH, Radant AD, Schork N, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Braff DL. The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration. Schizophr Bull. 2007 Jan; 33(1):33-48. PMID: 17035358; PMCID: PMC2632302.
      154. Schork N, Greenwood TA, Braff DL. Statistical genetics concepts and approaches in schizophrenia and related neuropsychiatric research. Schizophr Bull. 2007 Jan; 33(1):95-104. PMID: 17035359; PMCID: PMC2632283.
      155. Radant AD, Dobie DJ, Calkins ME, Olincy A, Braff DL, Cadenhead KS, Freedman R, Green MF, Greenwood TA, Gur RE, Light GA, Meichle SP, Mintz J, Nuechterlein KH, Schork N, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang MT, Turetsky BI, Tsuang DW. Successful multi-site measurement of antisaccade performance deficits in schizophrenia. Schizophr Res. 2007 Jan; 89(1-3):320-9. PMID: 17023145.
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      156. Wessel J, Schork N. Generalized genomic distance-based regression methodology for multilocus association analysis. Am J Hum Genet. 2006 Nov; 79(5):792-806. PMID: 17033957; PMCID: PMC1698575.
      157. Luo X, Kranzler HR, Zuo L, Wang S, Schork N, Gelernter J. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. Am J Hum Genet. 2006 Jun; 78(6):973-87. PMID: 16685648; PMCID: PMC1474098.
      158. Mathews CA, Jang KL, Herrera LD, Lowe TL, Budman CL, Erenberg G, Naarden A, Bruun RD, Schork N, Freimer NB, Reus VI. Tic symptom profiles in subjects with Tourette Syndrome from two genetically isolated populations. Biol Psychiatry. 2007 Feb 01; 61(3):292-300. PMID: 16581034.
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      159. Nievergelt CM, Kripke DF, Barrett TB, Burg E, Remick RA, Sadovnick AD, McElroy SL, Keck PE, Schork N, Kelsoe JR. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2006 Apr 05; 141B(3):234-41. PMID: 16528748; PMCID: PMC2651679.
      160. Seasholtz TM, Wessel J, Rao F, Rana BK, Khandrika S, Kennedy BP, Lillie EO, Ziegler MG, Smith DW, Schork N, Brown JH, O'Connor DT. Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity. Hypertension. 2006 May; 47(5):937-47. PMID: 16585408.
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      161. Chang YP, Kim JD, Schwander K, Rao DC, Miller MB, Weder AB, Cooper RS, Schork N, Province MA, Morrison AC, Kardia SL, Quertermous T, Chakravarti A. The impact of data quality on the identification of complex disease genes: experience from the Family Blood Pressure Program. Eur J Hum Genet. 2006 Apr; 14(4):469-77. PMID: 16493446.
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      162. Greenwood TA, Rao F, Stridsberg M, Mahapatra NR, Mahata M, Lillie EO, Mahata SK, Taupenot L, Schork N, O'Connor DT. Pleiotropic effects of novel trans-acting loci influencing human sympathochromaffin secretion. Physiol Genomics. 2006 May 16; 25(3):470-9. PMID: 16554546.
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      163. Libiger O, Schork N. Simulation-based homozygosity mapping with the GAW14 COGA dataset on alcoholism. BMC Genet. 2005 Dec 30; 6 Suppl 1:S35. PMID: 16451645; PMCID: PMC1866750.
      164. Stein MB, Fallin MD, Schork N, Gelernter J. COMT polymorphisms and anxiety-related personality traits. Neuropsychopharmacology. 2005 Nov; 30(11):2092-102. PMID: 15956988.
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      165. Schwimmer JB, Behling C, Newbury R, Deutsch R, Nievergelt C, Schork N, Lavine JE. Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology. 2005 Sep; 42(3):641-9. PMID: 16116629.
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      166. Murthy KK, Mahboubi VS, Santiago A, Barragan MT, Knöll R, Schultheiss HP, O'Connor DT, Schork N, Rana BK. Assessment of multiple displacement amplification for polymorphism discovery and haplotype determination at a highly polymorphic locus, MC1R. Hum Mutat. 2005 Aug; 26(2):145-52. PMID: 15957185.
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      167. Bao X, Mills PJ, Rana BK, Dimsdale JE, Schork N, Smith DW, Rao F, Milic M, O'Connor DT, Ziegler MG. Interactive effects of common beta2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function. Hypertension. 2005 Aug; 46(2):301-7. PMID: 16027244.
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      168. Etzel JP, Rana BK, Wen G, Parmer RJ, Schork N, O'Connor DT, Insel PA. Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. Hypertension. 2005 Jun; 45(6):1207-13. PMID: 15920038.
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      169. King D, Etzel JP, Chopra S, Smith J, Cadman PE, Rao F, Funk SD, Rana BK, Schork N, Insel PA, O'Connor DT. Human response to alpha2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype. Clin Pharmacol Ther. 2005 May; 77(5):388-403. PMID: 15900285.
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      170. Salem RM, Wessel J, Schork N. A comprehensive literature review of haplotyping software and methods for use with unrelated individuals. Hum Genomics. 2005 Mar; 2(1):39-66. PMID: 15814067; PMCID: PMC3525117.
      171. Reiner AP, Ziv E, Lind DL, Nievergelt CM, Schork N, Cummings SR, Phong A, Burchard EG, Harris TB, Psaty BM, Kwok PY. Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study. Am J Hum Genet. 2005 Mar; 76(3):463-77. PMID: 15660291; PMCID: PMC1196398.
      172. Soares ML, Coelho T, Sousa A, Batalov S, Conceição I, Sales-Luís ML, Ritchie MD, Williams SM, Nievergelt CM, Schork N, Saraiva MJ, Buxbaum JN. Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease. Hum Mol Genet. 2005 Feb 15; 14(4):543-53. PMID: 15649951.
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      173. Jorgenson E, Tang H, Gadde M, Province M, Leppert M, Kardia S, Schork N, Cooper R, Rao DC, Boerwinkle E, Risch N. Ethnicity and human genetic linkage maps. Am J Hum Genet. 2005 Feb; 76(2):276-90. PMID: 15627237; PMCID: PMC1196373.
      174. Tang H, Quertermous T, Rodriguez B, Kardia SL, Zhu X, Brown A, Pankow JS, Province MA, Hunt SC, Boerwinkle E, Schork N, Risch NJ. Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet. 2005 Feb; 76(2):268-75. PMID: 15625622; PMCID: PMC1196372.
      175. Zhang L, Rao F, Wessel J, Kennedy BP, Rana BK, Taupenot L, Lillie EO, Cockburn M, Schork N, Ziegler MG, O'Connor DT. Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins. Physiol Genomics. 2004 Nov 17; 19(3):277-91. PMID: 15367723.
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      176. Stein MB, Schork N, Gelernter J. A polymorphism of the beta1-adrenergic receptor is associated with low extraversion. Biol Psychiatry. 2004 Aug 15; 56(4):217-24. PMID: 15312808.
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      177. Greenwood TA, Rana BK, Schork N. Human haplotype block sizes are negatively correlated with recombination rates. Genome Res. 2004 Jul; 14(7):1358-61. PMID: 15231751; PMCID: PMC442152.
      178. Greenwood TA, Cadman PE, Stridsberg M, Nguyen S, Taupenot L, Schork N, O'Connor DT. Genome-wide linkage analysis of chromogranin B expression in the CEPH pedigrees: implications for exocytotic sympathochromaffin secretion in humans. Physiol Genomics. 2004 Jun 17; 18(1):119-27. PMID: 15138309.
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      179. Fries RS, Mahboubi P, Mahapatra NR, Mahata SK, Schork N, Schmid-Schoenbein GW, O'Connor DT. Neuroendocrine transcriptome in genetic hypertension: multiple changes in diverse adrenal physiological systems. Hypertension. 2004 Jun; 43(6):1301-11. PMID: 15166183.
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      180. Nievergelt CM, Smith DW, Kohlenberg JB, Schork N. Large-scale integration of human genetic and physical maps. Genome Res. 2004 Jun; 14(6):1199-205. PMID: 15140834; PMCID: PMC419799.
      181. Schork N, Greenwood TA. Inherent bias toward the null hypothesis in conventional multipoint nonparametric linkage analysis. Am J Hum Genet. 2004 Feb; 74(2):306-16. PMID: 14732904; PMCID: PMC1181928.
      182. Wen G, Mahata SK, Cadman P, Mahata M, Ghosh S, Mahapatra NR, Rao F, Stridsberg M, Smith DW, Mahboubi P, Schork N, O'Connor DT, Hamilton BA. Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. Am J Hum Genet. 2004 Feb; 74(2):197-207. PMID: 14740315; PMCID: PMC1181918.
      183. Conti LH, Jirout M, Breen L, Vanella JJ, Schork N, Printz MP. Identification of quantitative trait Loci for anxiety and locomotion phenotypes in rat recombinant inbred strains. Behav Genet. 2004 Jan; 34(1):93-103. PMID: 14739700.
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      184. Broeckel U, Schork N. Identifying genes and genetic variation underlying human diseases and complex phenotypes via recombination mapping. J Physiol. 2004 Jan 01; 554(Pt 1):40-5. PMID: 14678489; PMCID: PMC1664744.
      185. Gold DA, Baek SH, Schork N, Rose DW, Larsen DD, Sachs BD, Rosenfeld MG, Hamilton BA. RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 2003 Dec 18; 40(6):1119-31. PMID: 14687547; PMCID: PMC2717708.
      186. Jirout M, Krenová D, Kren V, Breen L, Pravenec M, Schork N, Printz MP. A new framework marker-based linkage map and SDPs for the rat HXB/BXH strain set. Mamm Genome. 2003 Aug; 14(8):537-46. PMID: 12925886.
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      187. Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork N, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002 Dec 27; 111(7):943-55. PMID: 12507422.
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      188. Schork N, Gardner JP, Zhang L, Fallin D, Thiel B, Jakubowski H, Aviv A. Genomic association/linkage of sodium lithium countertransport in CEPH pedigrees. Hypertension. 2002 Nov; 40(5):619-28. PMID: 12411453.
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      189. Kotchen TA, Broeckel U, Grim CE, Hamet P, Jacob H, Kaldunski ML, Kotchen JM, Schork N, Tonellato PJ, Cowley AW. Identification of hypertension-related QTLs in African American sib pairs. Hypertension. 2002 Nov; 40(5):634-9. PMID: 12411455.
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      190. Schork N. Power calculations for genetic association studies using estimated probability distributions. Am J Hum Genet. 2002 Jun; 70(6):1480-9. PMID: 11992254; PMCID: PMC379135.
      191. Shaw SH, Hutchison D, Saiz R, Abel K, DeLisi LE, Schork N, Sherrington R. Evaluation of linkage disequilibrium between chromosome 22q11 single nucleotide polymorphisms in a large outbred population. Am J Med Genet. 2002 Mar 08; 114(2):205-13. PMID: 11857583.
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