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    Neal Devaraj

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentChemistry and Biochemistry
    Address9500 Gilman Drive #0359
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Enzymatic Site-Specific Labeling of RNA for Affinity Isolation
      NIH/NIGMS R01GM123285Sep 20, 2017 - Aug 31, 2021
      Role: Principal Investigator
      Amplifying PET Imaging Signals for In Vivo Detection of Pancreatic Beta-cells
      NIH/NIDDK DP2DK111801Sep 25, 2016 - Jun 30, 2021
      Role: Principal Investigator
      Fast in vivo CLICK chemistries for PET imaging
      NIH/NIBIB K01EB010078May 15, 2010 - Apr 30, 2015
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Ehret F, Zhou CY, Alexander SC, Zhang D, Devaraj N. Site-Specific Covalent Conjugation of Modified mRNA by tRNA Guanine Transglycosylase. Mol Pharm. 2017 Aug 15. PMID: 28749687.
        View in: PubMed
      2. Alexander SC, Devaraj N. Developing a Fluorescent Toolbox To Shed Light on the Mysteries of RNA. Biochemistry. 2017 Jul 14. PMID: 28671838.
        View in: PubMed
      3. Brea RJ, Devaraj N. Tension Promoted Sulfur Exchange for Cellular Delivery. ACS Cent Sci. 2017 Jun 28; 3(6):524-525. PMID: 28691060.
        View in: PubMed
      4. Brea RJ, Cole CM, Lyda BR, Ye L, Prosser RS, Sunahara RK, Devaraj N. In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes. J Am Chem Soc. 2017 Mar 15; 139(10):3607-3610. PMID: 28263576.
        View in: PubMed
      5. Wu H, Alexander SC, Jin S, Devaraj N. A Bioorthogonal Near-Infrared Fluorogenic Probe for mRNA Detection. J Am Chem Soc. 2016 Sep 14; 138(36):11429-32. PMID: 27510580.
        View in: PubMed
      6. Wu H, Devaraj N. Mining Proteomes Using Bioorthogonal Probes. Cell Chem Biol. 2016 Jul 21; 23(7):751-3. PMID: 27447043.
        View in: PubMed
      7. Brea RJ, Rudd AK, Devaraj N. Nonenzymatic biomimetic remodeling of phospholipids in synthetic liposomes. Proc Natl Acad Sci U S A. 2016 Aug 02; 113(31):8589-94. PMID: 27439858; PMCID: PMC4978229 [Available on 02/02/17].
      8. Hardy MD, Konetski D, Bowman CN, Devaraj N. Ruthenium photoredox-triggered phospholipid membrane formation. Org Biomol Chem. 2016 Jun 15; 14(24):5555-8. PMID: 26924258.
        View in: PubMed
      9. Carell T, Vrabel M, Yang M, Yang Y, Chen PR, Dommerholt J, Rutjes FP, van Delft FL, Herner A, Lin Q, Wu H, Devaraj N, Kath-Schorr S. Erratum to: M. Vrabel and T. Carell for Cycloadditions in Bioorthogonal Chemistry. Top Curr Chem (J). 2016 Jun; 374(3):23. PMID: 27573263.
        View in: PubMed
      10. Chowdhuri S, Cole CM, Devaraj N. Encapsulation of Living Cells within Giant Phospholipid Liposomes Formed by the Inverse-Emulsion Technique. Chembiochem. 2016 05 17; 17(10):886-9. PMID: 26919463.
        View in: PubMed
      11. Carell T, Vrabel M, Yang M, Yang Y, Chen PR, Dommerholt J, Rutjes FP, van Delft FL, Herner A, Lin Q, Wu H, Devaraj N, Kath-Schorr S. M. Vrabel and T. Carell for Cycloadditions in Bioorthogonal Chemistry. Top Curr Chem (J). 2016 Apr; 374(2):15. PMID: 27573140.
        View in: PubMed
      12. Wu H, Devaraj N. Inverse Electron-Demand Diels-Alder Bioorthogonal Reactions. Top Curr Chem (J). 2016 Feb; 374(1):3. PMID: 27572986.
        View in: PubMed
      13. Alexander SC, Busby KN, Cole CM, Zhou CY, Devaraj N. Site-Specific Covalent Labeling of RNA by Enzymatic Transglycosylation. J Am Chem Soc. 2015 Oct 14; 137(40):12756-9. PMID: 26393285.
        View in: PubMed
      14. Cole CM, Brea RJ, Kim YH, Hardy MD, Yang J, Devaraj N. Spontaneous Reconstitution of Functional Transmembrane Proteins During Bioorthogonal Phospholipid Membrane Synthesis. Angew Chem Int Ed Engl. 2015 Oct 19; 54(43):12738-42. PMID: 26316292.
        View in: PubMed
      15. Ehret F, Wu H, Alexander SC, Devaraj N. Electrochemical Control of Rapid Bioorthogonal Tetrazine Ligations for Selective Functionalization of Microelectrodes. J Am Chem Soc. 2015 Jul 22; 137(28):8876-9. PMID: 26132207.
        View in: PubMed
      16. Brea RJ, Hardy MD, Devaraj N. Towards self-assembled hybrid artificial cells: novel bottom-up approaches to functional synthetic membranes. Chemistry. 2015 Sep 01; 21(36):12564-70. PMID: 26149747; PMCID: PMC4617832.
      17. Hardy MD, Yang J, Selimkhanov J, Cole CM, Tsimring LS, Devaraj N. Self-reproducing catalyst drives repeated phospholipid synthesis and membrane growth. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8187-92. PMID: 26100914; PMCID: PMC4500204.
      18. Rudd AK, Valls Cuevas JM, Devaraj N. SNAP-Tag-Reactive Lipid Anchors Enable Targeted and Spatiotemporally Controlled Localization of Proteins to Phospholipid Membranes. J Am Chem Soc. 2015 Apr 22; 137(15):4884-7. PMID: 25830488.
        View in: PubMed
      19. Wu H, Cisneros BT, Cole CM, Devaraj N. Bioorthogonal tetrazine-mediated transfer reactions facilitate reaction turnover in nucleic acid-templated detection of microRNA. J Am Chem Soc. 2014 Dec 31; 136(52):17942-5. PMID: 25495860; PMCID: PMC4291768.
      20. Brea RJ, Cole CM, Devaraj N. In situ vesicle formation by native chemical ligation. Angew Chem Int Ed Engl. 2014 Dec 15; 53(51):14102-5. PMID: 25346090; PMCID: PMC4418804.
      21. Wu H, Yang J, Šeckute J, Devaraj N. In situ synthesis of alkenyl tetrazines for highly fluorogenic bioorthogonal live-cell imaging probes. Angew Chem Int Ed Engl. 2014 Jun 02; 53(23):5805-9. PMID: 24764312; PMCID: PMC4104127.
      22. Nichols B, Qin Z, Yang J, Vera DR, Devaraj N. 68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers. Chem Commun (Camb). 2014 May 25; 50(40):5215-5217. PMID: 24589653; PMCID: PMC4119763.
      23. Yang J, Liang Y, Šeckute J, Houk KN, Devaraj N. Synthesis and reactivity comparisons of 1-methyl-3-substituted cyclopropene mini-tags for tetrazine bioorthogonal reactions. Chemistry. 2014 Mar 17; 20(12):3365-75. PMID: 24615990; PMCID: PMC4020353.
      24. Seckute J, Devaraj N. Expanding room for tetrazine ligations in the in vivo chemistry toolbox. Curr Opin Chem Biol. 2013 Oct; 17(5):761-7. PMID: 24021760; PMCID: PMC4002580.
      25. Seckute J, Yang J, Devaraj N. Rapid oligonucleotide-templated fluorogenic tetrazine ligations. Nucleic Acids Res. 2013 Aug; 41(15):e148. PMID: 23775794; PMCID: PMC3753649.
      26. Yang J, Šeckute J, Cole CM, Devaraj N. Live-cell imaging of cyclopropene tags with fluorogenic tetrazine cycloadditions. Angew Chem Int Ed Engl. 2012 Jul 23; 51(30):7476-9. PMID: 22696426; PMCID: PMC3431913.
      27. Yang J, Karver MR, Li W, Sahu S, Devaraj N. Metal-catalyzed one-pot synthesis of tetrazines directly from aliphatic nitriles and hydrazine. Angew Chem Int Ed Engl. 2012 May 21; 51(21):5222-5. PMID: 22511586; PMCID: PMC3434974.
      28. Devaraj N, Thurber GM, Keliher EJ, Marinelli B, Weissleder R. Reactive polymer enables efficient in vivo bioorthogonal chemistry. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4762-7. PMID: 22411831; PMCID: PMC3324005.
      29. Budin I, Devaraj N. Membrane assembly driven by a biomimetic coupling reaction. J Am Chem Soc. 2012 Jan 18; 134(2):751-3. PMID: 22239722; PMCID: PMC3262119.
      30. Devaraj N, Weissleder R. Biomedical applications of tetrazine cycloadditions. Acc Chem Res. 2011 Sep 20; 44(9):816-27. PMID: 21627112; PMCID: PMC3166440.
      31. Haun JB, Devaraj N, Marinelli BS, Lee H, Weissleder R. Probing intracellular biomarkers and mediators of cell activation using nanosensors and bioorthogonal chemistry. ACS Nano. 2011 Apr 26; 5(4):3204-13. PMID: 21351804; PMCID: PMC3088084.
      32. Haun JB, Devaraj N, Hilderbrand SA, Lee H, Weissleder R. Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat Nanotechnol. 2010 Sep; 5(9):660-5. PMID: 20676091; PMCID: PMC2934903.
      33. Han HS, Devaraj N, Lee J, Hilderbrand SA, Weissleder R, Bawendi MG. Development of a bioorthogonal and highly efficient conjugation method for quantum dots using tetrazine-norbornene cycloaddition. J Am Chem Soc. 2010 Jun 16; 132(23):7838-9. PMID: 20481508; PMCID: PMC2892974.
      34. Devaraj N, Hilderbrand S, Upadhyay R, Mazitschek R, Weissleder R. Bioorthogonal turn-on probes for imaging small molecules inside living cells. Angew Chem Int Ed Engl. 2010 Apr 06; 49(16):2869-72. PMID: 20306505; PMCID: PMC3433403.
      35. Devaraj N, Keliher EJ, Thurber GM, Nahrendorf M, Weissleder R. 18F labeled nanoparticles for in vivo PET-CT imaging. Bioconjug Chem. 2009 Feb; 20(2):397-401. PMID: 19138113; PMCID: PMC2644737.
      36. Devaraj N, Upadhyay R, Haun JB, Hilderbrand SA, Weissleder R. Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition. Angew Chem Int Ed Engl. 2009; 48(38):7013-6. PMID: 19697389; PMCID: PMC2790075.
      37. Devaraj N, Weissleder R, Hilderbrand SA. Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem. 2008 Dec; 19(12):2297-9. PMID: 19053305; PMCID: PMC2677645.
      38. Decréau RA, Collman JP, Yang Y, Yan Y, Devaraj N. Syntheses of hemoprotein models that can be covalently attached onto electrode surfaces by click chemistry. J Org Chem. 2007 Apr 13; 72(8):2794-802. PMID: 17375955; PMCID: PMC2532528.
      39. Collman JP, Devaraj N, Decréau RA, Yang Y, Yan YL, Ebina W, Eberspacher TA, Chidsey CE. A cytochrome C oxidase model catalyzes oxygen to water reduction under rate-limiting electron flux. Science. 2007 Mar 16; 315(5818):1565-8. PMID: 17363671; PMCID: PMC3064436.
      40. Devaraj N, Decreau RA, Ebina W, Collman JP, Chidsey CE. Rate of interfacial electron transfer through the 1,2,3-triazole linkage. J Phys Chem B. 2006 Aug 17; 110(32):15955-62. PMID: 16898751; PMCID: PMC3434967.
      41. Collman JP, Devaraj N, Eberspacher TP, Chidsey CE. Mixed azide-terminated monolayers: a platform for modifying electrode surfaces. Langmuir. 2006 Mar 14; 22(6):2457-64. PMID: 16519441; PMCID: PMC1513191.
      42. Devaraj N, Dinolfo PH, Chidsey CE, Collman JP. Selective functionalization of independently addressed microelectrodes by electrochemical activation and deactivation of a coupling catalyst. J Am Chem Soc. 2006 Feb 15; 128(6):1794-5. PMID: 16464070; PMCID: PMC1473176.
      43. Devaraj N, Miller GP, Ebina W, Kakaradov B, Collman JP, Kool ET, Chidsey CE. Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers. J Am Chem Soc. 2005 Jun 22; 127(24):8600-1. PMID: 15954758; PMCID: PMC3431914.
      44. Collman JP, Devaraj N, Chidsey CE. "Clicking" functionality onto electrode surfaces. Langmuir. 2004 Feb 17; 20(4):1051-3. PMID: 15803676; PMCID: PMC3428800.
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