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Nazneen Dewji
Title
Associate Adjunct Professor
School
University of California, San Diego
Department
Medicine
Address
9500 Gilman Drive #0681
CA La Jolla 92093
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Research
Research Activities and Funding
Small molecule therapeutics for Alzheimer's Disease
NIH/NIA
R43AG055182
Sep 30, 2016 - Aug 31, 2017
Role: Principal Investigator
Progressing the Pre-clinical development of P8 for Alzheimer's Disease
NIH/NIA
R44AG043278
Aug 1, 2012 - May 31, 2019
Role: Principal Investigator
Intranasal Delivery of Peptide Drugs to the Brain
NIH/NIA
R43AG043278
Aug 1, 2012 - Nov 30, 2013
Role: Principal Investigator
The Presenilins as G-Protein Coupled Receptors
NIH/NINDS
R01NS055161
Jun 15, 2007 - Mar 31, 2013
Role: Principal Investigator
Mechanisms of beta-Amyloid Precursor Protein Processing in the Brain
NIH/NINDS
R01NS044768
Dec 1, 2003 - Nov 30, 2007
Role: Principal Investigator
CELLULAR FUNCTIONS OF ALZHEIMER'S DISEASE PROTEINS
NIH/NIA
R01AG017888
May 15, 2000 - Apr 30, 2005
Role: Principal Investigator
BETA AMYLOID DERIVATION IN BRAIN IN ALZHEIMERS DISEASE
NIH/NINDS
R01NS027580
Aug 1, 1989 - Mar 31, 2003
Role: Principal Investigator
Bibliographic
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can
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Dewji N
, Singer SJ, Masliah E, Rockenstein E, Kim M, Harber M, Horwood T. Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's disease. PLoS One. 2015; 10(4):e0122451. PMID: 25923432; PMCID: PMC4414571.
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,
PubMed Central
Dewji N
. Presenilin structure in mechanisms leading to Alzheimer's disease. J Alzheimers Dis. 2006 Nov; 10(2-3):277-90. PMID: 17119293.
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PubMed
Dewji N
, Mukhopadhyay D, Singer SJ. An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1540-5. PMID: 16432203; PMCID: PMC1345709.
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PubMed
,
PubMed Central
Singer SJ,
Dewji N
. Evidence that Perutz's double-beta-stranded subunit structure for beta-amyloids also applies to their channel-forming structures in membranes. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1546-50. PMID: 16432204; PMCID: PMC1345708.
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PubMed Central
Dewji N
. The structure and functions of the presenilins. Cell Mol Life Sci. 2005 May; 62(10):1109-19. PMID: 15798893.
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PubMed
Dewji N
, Valdez D, Singer SJ. The presenilins turned inside out: implications for their structures and functions. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):1057-62. PMID: 14732691; PMCID: PMC327150.
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PubMed Central
Dewji N
, Singer SJ. Specific intercellular binding of the beta-amyloid precursor protein to the presenilins induces intercellular signaling: its significance for Alzheimer's disease. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):15055-60. PMID: 9844014; PMCID: PMC24574.
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PubMed Central
Dewji N
, Singer SJ. The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14025-30. PMID: 9391146; PMCID: PMC28426.
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PubMed Central
Dewji N
, Do C, Singer SJ. On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14031-6. PMID: 9391147; PMCID: PMC28427.
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PubMed Central
Dewji N
, Singer SJ. Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9926-31. PMID: 9275228; PMCID: PMC23298.
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PubMed Central
Dewji N
, Singer SJ. Specific transcellular binding between membrane proteins crucial to Alzheimer disease. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12575-80. PMID: 8901624; PMCID: PMC38034.
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PubMed Central
Dewji N
, Singer SJ. Genetic clues to Alzheimer's disease. Science. 1996 Jan 12; 271(5246):159-60. PMID: 8539612.
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PubMed
Dewji N
, Do C. Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress. Brain Res Mol Brain Res. 1996 Jan; 35(1-2):325-8. PMID: 8717371.
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Dewji N
, Do C, Bayney RM. Transcriptional activation of Alzheimer's beta-amyloid precursor protein gene by stress. Brain Res Mol Brain Res. 1995 Nov; 33(2):245-53. PMID: 8750883.
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PubMed
Trejo J, Massamiri T, Deng T,
Dewji N
, Bayney RM, Brown JH. A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. J Biol Chem. 1994 Aug 26; 269(34):21682-90. PMID: 8063812.
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PubMed
Hall NA, Lake BD,
Dewji N
, Patrick AD. Lysosomal storage of subunit c of mitochondrial ATP synthase in Batten's disease (ceroid-lipofuscinosis). Biochem J. 1991 Apr 01; 275 ( Pt 1):269-72. PMID: 1826833; PMCID: PMC1150044.
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PubMed Central
Adler MJ, Coronel C, Shelton E, Seegmiller JE,
Dewji N
. Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):16-20. PMID: 1702541; PMCID: PMC50738.
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PubMed
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PubMed Central
Dewji N
, Shelton ER, Adler MJ, Chan HW, Seegmiller JE, Coronel C. Processing of Alzheimer's disease-associated beta-amyloid precursor protein. J Mol Neurosci. 1990; 2(1):19-27. PMID: 2124135.
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PubMed
O'Brien JS, Kretz KA,
Dewji N
, Wenger DA, Esch F, Fluharty AL. Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) by same genetic locus. Science. 1988 Aug 26; 241(4869):1098-101. PMID: 2842863.
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PubMed
Dewji N
, Wenger DA, O'Brien JS. Nucleotide sequence of cloned cDNA for human sphingolipid activator protein 1 precursor. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8652-6. PMID: 2825202; PMCID: PMC299604.
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PubMed Central
Kao FT, Law ML, Hartz J, Jones C, Zhang XL,
Dewji N
, O'Brien JS, Wenger DA. Regional localization of the gene coding for sphingolipid activator protein SAP-1 on human chromosome 10. Somat Cell Mol Genet. 1987 Nov; 13(6):685-8. PMID: 3478817.
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PubMed
Dewji N
, De-Keyzer DR, Stirling JL. Purification and characterization of beta-N-acetylhexosaminidase I2 from human liver. Biochem J. 1986 Feb 15; 234(1):157-62. PMID: 2423070; PMCID: PMC1146539.
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PubMed Central
Dewji N
, Wenger D, Fujibayashi S, Donoviel M, Esch F, Hill F, O'Brien JS. Molecular cloning of the sphingolipid activator protein-1 (SAP-1), the sulfatide sulfatase activator. Biochem Biophys Res Commun. 1986 Jan 29; 134(2):989-94. PMID: 2868718.
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PubMed
de Wet JR, Fukushima H,
Dewji N
, Wilcox E, O'Brien JS, Helinski DR. Chromogenic immunodetection of human serum albumin and alpha-L-fucosidase clones in a human hepatoma cDNA expression library. DNA. 1984 Dec; 3(6):437-47. PMID: 6096099.
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Wood KV, de Wet JR,
Dewji N
, DeLuca M. Synthesis of active firefly luciferase by in vitro translation of RNA obtained from adult lanterns. Biochem Biophys Res Commun. 1984 Oct 30; 124(2):592-6. PMID: 6208909.
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Dewji N
, Rapson N, Greaves M, Ellis R. Isoenzyme profiles of lysosomal hydrolases in leukaemic cells. Leuk Res. 1981; 5(1):19-27. PMID: 6262581.
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View timeline visualization
Year
Publications
1981
1
1984
2
1986
2
1987
2
1988
1
1990
1
1991
2
1994
1
1995
1
1996
3
1997
3
1998
1
2004
1
2005
1
2006
3
2015
1
Nazneen's Networks
Concepts
Derived automatically from this person's publications.
Alzheimer Disease
Amyloid beta-Peptides
Presenilin-1
Membrane Proteins
Amyloid beta-Protein Precursor
See all (169) concept(s)
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Co-Authors
People in Profiles who have published with this person.
Masliah, Eliezer
Helinski, Donald
See all (2) people
_
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Same Department
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