|School||University of California, San Diego|
|Address||9500 Gilman Drive #0613|
CA La Jolla 92093
|School of Medicine||M.D., Ph.D.||Boston University|
Diverse environmental exposures - including host factors, microbiota, dietary components, drugs, toxicants and pollutants – serve as critical drivers of human physiology and disease. These exposures introduce small molecule mediators into human circulation which in turn result in protein / DNA modification, altered cell signaling, and dysregulation of cellular metabolism. Our laboratory at UC San Diego utilizes cutting edge mass spectrometry based metabolomics in conjunction with population scale human biosamples and large-scale data integration to map the environmental landscape of human disease. In addition, we make use of genome engineering and cellular, fish and animal models to define the mechanisms and metabolic consequences of disease. Our laboratory consists of an interdisciplinary team with diverse expertise encompassing analytical chemistry, high-throughput biology, computational biology, metabolic biochemistry, cellular biology, biomedical and clinical epidemiology. Our work is performed in close collaboration with a team of investigators based at UC (San Diego), Harvard Medical School (Boston) and Karoliska Institute (Stockholm).
Human Biology, Metabolic Biochemistry, Integrative Biology, Mass Spectrometry, Metabolomics
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