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    Mohit Jain

    TitleAssistant Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0613
    CA La Jolla 92093
    Phone858-822-5854
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      Collapse Biography 
      Collapse Education and Training
      School of MedicineM.D., Ph.D.Boston University

      Collapse Overview 
      Collapse Overview
      Diverse environmental exposures - including host factors, microbiota, dietary components, drugs, toxicants and pollutants – serve as critical drivers of human physiology and disease. These exposures introduce small molecule mediators into human circulation which in turn result in protein / DNA modification, altered cell signaling, and dysregulation of cellular metabolism. Our laboratory at UC San Diego utilizes cutting edge mass spectrometry based metabolomics in conjunction with population scale human biosamples and large-scale data integration to map the environmental landscape of human disease. In addition, we make use of genome engineering and cellular, fish and animal models to define the mechanisms and metabolic consequences of disease. Our laboratory consists of an interdisciplinary team with diverse expertise encompassing analytical chemistry, high-throughput biology, computational biology, metabolic biochemistry, cellular biology, biomedical and clinical epidemiology. Our work is performed in close collaboration with a team of investigators based at UC (San Diego), Harvard Medical School (Boston) and Karoliska Institute (Stockholm).

      Collapse Interests
      Human Biology, Metabolic Biochemistry, Integrative Biology, Mass Spectrometry, Metabolomics

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      Collapse NIH Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Sapp V, Jain M, Liao R. Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy. Physiology (Bethesda). 2016 Jul; 31(4):294-9. PMID: 27252164.
        View in: PubMed
      2. Jain M, Ngoy S, Sheth SA, Swanson RA, Rhee EP, Liao R, Clish CB, Mootha VK, Nilsson R. A systematic survey of lipids across mouse tissues. Am J Physiol Endocrinol Metab. 2014 Apr 15; 306(8):E854-68. PMID: 24518676; PMCID: PMC3989739.
        View in: PubMed
        View in: PubMed Central
      3. Shi J, Jiang B, Qiu Y, Guan J, Jain M, Cao X, Bauer M, Su L, Burkly LC, Leone TC, Kelly DP, Liao R. PGC1a plays a critical role in TWEAK-induced cardiac dysfunction. PLoS One. 2013; 8(1):e54054. PMID: 23342071; PMCID: PMC3546975.
        View in: PubMed
        View in: PubMed Central
      4. Unno K, Jain M, Liao R. Cardiac side population cells: moving toward the center stage in cardiac regeneration. Circ Res. 2012 May 11; 110(10):1355-63. PMID: 22581921; NIHMSID: NIHMS369237.
        View in: PubMed
      5. Bauer M, Cheng S, Jain M, Ngoy S, Theodoropoulos C, Trujillo A, Lin FC, Liao R. Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice. Circ Res. 2011 Apr 15; 108(8):908-16. PMID: 21372284; NIHMSID: NIHMS282550.
        View in: PubMed
      6. Lim CC, Bryan NS, Jain M, Garcia-Saura MF, Fernandez BO, Sawyer DB, Handy DE, Loscalzo J, Feelisch M, Liao R. Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. Am J Physiol Heart Circ Physiol. 2009 Dec; 297(6):H2144-53. PMID: 19801492; PMCID: PMC2793140.
        View in: PubMed
        View in: PubMed Central
      7. Jain M, Jakubowski A, Cui L, Shi J, Su L, Bauer M, Guan J, Lim CC, Naito Y, Thompson JS, Sam F, Ambrose C, Parr M, Crowell T, Lincecum JM, Wang MZ, Hsu YM, Zheng TS, Michaelson JS, Liao R, Burkly LC. A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation. 2009 Apr 21; 119(15):2058-68. PMID: 19349318; NIHMSID: NIHMS126396.
        View in: PubMed
      8. Luptak I, Yan J, Cui L, Jain M, Liao R, Tian R. Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress. Circulation. 2007 Aug 21; 116(8):901-9. PMID: 17679614.
        View in: PubMed
      9. Liao R, Pfister O, Jain M, Mouquet F. The bone marrow--cardiac axis of myocardial regeneration. Prog Cardiovasc Dis. 2007 Jul-Aug; 50(1):18-30. PMID: 17631435; NIHMSID: NIHMS28010.
        View in: PubMed
      10. Sohn RL, Jain M, Liao R. Adult stem cells and heart regeneration. Expert Rev Cardiovasc Ther. 2007 May; 5(3):507-17. PMID: 17489674.
        View in: PubMed
      11. Liao R, Jain M. Isolation, culture, and functional analysis of adult mouse cardiomyocytes. Methods Mol Med. 2007; 139:251-62. PMID: 18287677.
        View in: PubMed
      12. Mouquet F, Pfister O, Jain M, Oikonomopoulos A, Ngoy S, Summer R, Fine A, Liao R. Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ Res. 2005 Nov 25; 97(11):1090-2. PMID: 16269652.
        View in: PubMed
      13. Pfister O, Jain M, Liao R. Cell therapy in heart failure. Heart Fail Clin. 2005 Jul; 1(2):303-12. PMID: 17386854.
        View in: PubMed
      14. Pfister O, Mouquet F, Jain M, Summer R, Helmes M, Fine A, Colucci WS, Liao R. CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. Circ Res. 2005 Jul 8; 97(1):52-61. PMID: 15947249.
        View in: PubMed
      15. Jain M, Pfister O, Hajjar RJ, Liao R. Mesenchymal stem cells in the infarcted heart. Coron Artery Dis. 2005 Mar; 16(2):93-7. PMID: 15735401.
        View in: PubMed
      16. Brenner DA, Jain M, Pimentel DR, Wang B, Connors LH, Skinner M, Apstein CS, Liao R. Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res. 2004 Apr 30; 94(8):1008-10. PMID: 15044325.
        View in: PubMed
      17. Jain M, Cui L, Brenner DA, Wang B, Handy DE, Leopold JA, Loscalzo J, Apstein CS, Liao R. Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation. 2004 Feb 24; 109(7):898-903. PMID: 14757696.
        View in: PubMed
      18. Jain M, Brenner DA, Cui L, Lim CC, Wang B, Pimentel DR, Koh S, Sawyer DB, Leopold JA, Handy DE, Loscalzo J, Apstein CS, Liao R. Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res. 2003 Jul 25; 93(2):e9-16. PMID: 12829617.
        View in: PubMed
      19. Liao R, Jain M, Cui L, D'Agostino J, Aiello F, Luptak I, Ngoy S, Mortensen RM, Tian R. Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice. Circulation. 2002 Oct 15; 106(16):2125-31. PMID: 12379584.
        View in: PubMed
      20. Jain M, Liao R, Podesser BK, Ngoy S, Apstein CS, Eberli FR. Influence of gender on the response to hemodynamic overload after myocardial infarction. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2544-50. PMID: 12388328.
        View in: PubMed
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