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Michael Yaffe
Title
Emeritus Professor
School
University of California, San Diego
Department
Cell and Developmental Biology
Address
9500 Gilman Drive #0347
CA La Jolla 92093
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Research
Research Activities and Funding
Mechanisms of Mitochondrial Division and Inheritance
NIH/NIGMS
R01GM044614
Apr 1, 1993 - Mar 31, 2006
Role: Principal Investigator
BIOGENESIS OF THE MITOCHONDRIAL OUTER MEMBRANE
NIH/NIGMS
R01GM035315
Jul 1, 1985 - Jun 30, 1988
Role: Principal Investigator
Bibliographic
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can
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Timeline
Publications by year:
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Yaffe M
, Noggle SA, Solomon SL. Raising the standards of stem cell line quality. Nat Cell Biol. 2016 Mar; 18(3):236-7. PMID: 26911906.
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PubMed
Dewitt ND,
Yaffe M
, Trounson A. Building stem-cell genomics in California and beyond. Nat Biotechnol. 2012 Jan 09; 30(1):20-5. PMID: 22231086.
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PubMed
Area-Gomez E, de Groof AJ, Boldogh I, Bird TD, Gibson GE, Koehler CM, Yu WH, Duff KE,
Yaffe M
, Pon LA, Schon EA. Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. Am J Pathol. 2009 Nov; 175(5):1810-6. PMID: 19834068; PMCID: PMC2774047.
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PubMed
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PubMed Central
Mazanka E, Alexander J, Yeh BJ, Charoenpong P, Lowery DM,
Yaffe M
, Weiss EL. The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry. PLoS Biol. 2008 Aug 19; 6(8):e203. PMID: 18715118; PMCID: PMC2517623.
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PubMed
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PubMed Central
Chiron S, Bobkova A, Zhou H,
Yaffe M
. CLASP regulates mitochondrial distribution in Schizosaccharomyces pombe. J Cell Biol. 2008 Jul 14; 182(1):41-9. PMID: 18606849; PMCID: PMC2447910.
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PubMed
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PubMed Central
Gourley PL, Hendricks JK, McDonald AE, Copeland RG,
Yaffe M
, Naviaux RK. Reactive biomolecular divergence in genetically altered yeast cells and isolated mitochondria as measured by biocavity laser spectroscopy: rapid diagnostic method for studying cellular responses to stress and disease. J Biomed Opt. 2007 Sep-Oct; 12(5):054003. PMID: 17994891.
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PubMed
Sesaki H, Dunn CD, Iijima M, Shepard KA,
Yaffe M
, Machamer CE, Jensen RE. Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. J Cell Biol. 2006 Jun 05; 173(5):651-8. PMID: 16754953; PMCID: PMC2063882.
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PubMed
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PubMed Central
Meisinger C, Rissler M, Chacinska A, Szklarz LK, Milenkovic D, Kozjak V, Schönfisch B, Lohaus C, Meyer HE,
Yaffe M
, Guiard B, Wiedemann N, Pfanner N. The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev Cell. 2004 Jul; 7(1):61-71. PMID: 15239954.
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PubMed
Weir BA,
Yaffe M
. Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe. Mol Biol Cell. 2004 Apr; 15(4):1656-65. PMID: 14767070; PMCID: PMC379264.
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PubMed
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PubMed Central
Yaffe M
, Stuurman N, Vale RD. Mitochondrial positioning in fission yeast is driven by association with dynamic microtubules and mitotic spindle poles. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11424-8. PMID: 12972644; PMCID: PMC208773.
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PubMed
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PubMed Central
Yaffe M
. The cutting edge of mitochondrial fusion. Nat Cell Biol. 2003 Jun; 5(6):497-9. PMID: 12776123.
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PubMed
Sesaki H, Southard SM,
Yaffe M
, Jensen RE. Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell. 2003 Jun; 14(6):2342-56. PMID: 12808034; PMCID: PMC194884.
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PubMed
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PubMed Central
Berger KH,
Yaffe M
. Mitochondrial DNA inheritance in Saccharomyces cerevisiae. Trends Microbiol. 2000 Nov; 8(11):508-13. PMID: 11121761.
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PubMed
Fekkes P, Shepard KA,
Yaffe M
. Gag3p, an outer membrane protein required for fission of mitochondrial tubules. J Cell Biol. 2000 Oct 16; 151(2):333-40. PMID: 11038180; PMCID: PMC2192644.
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PubMed
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PubMed Central
Kluck RM, Ellerby LM, Ellerby HM, Naiem S,
Yaffe M
, Margoliash E, Bredesen D, Mauk AG, Sherman F, Newmeyer DD. Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation. J Biol Chem. 2000 May 26; 275(21):16127-33. PMID: 10821864.
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PubMed
Yaffe M
. Dynamic mitochondria. Nat Cell Biol. 1999 Oct; 1(6):E149-50. PMID: 10559975.
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PubMed
Fisk HA,
Yaffe M
. A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae. J Cell Biol. 1999 Jun 14; 145(6):1199-208. PMID: 10366593; PMCID: PMC2133147.
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PubMed
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PubMed Central
Yaffe M
. The machinery of mitochondrial inheritance and behavior. Science. 1999 Mar 05; 283(5407):1493-7. PMID: 10066164.
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PubMed
Shepard KA,
Yaffe M
. The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance. J Cell Biol. 1999 Feb 22; 144(4):711-20. PMID: 10037792; PMCID: PMC2132935.
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PubMed
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PubMed Central
Berger KH,
Yaffe M
. Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol. 1998 Jul; 18(7):4043-52. PMID: 9632789; PMCID: PMC108989.
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PubMed
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PubMed Central
Yaffe M
. Mitochondrial morphogenesis: fusion factor for fly fertility. Curr Biol. 1997 Dec 01; 7(12):R782-3. PMID: 9382824.
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PubMed
Fisk HA,
Yaffe M
. Mutational analysis of Mdm1p function in nuclear and mitochondrial inheritance. J Cell Biol. 1997 Aug 11; 138(3):485-94. PMID: 9245780; PMCID: PMC2141631.
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PubMed
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PubMed Central
Berger KH, Sogo LF,
Yaffe M
. Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast. J Cell Biol. 1997 Feb 10; 136(3):545-53. PMID: 9024686; PMCID: PMC2134291.
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PubMed
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PubMed Central
Berger KH,
Yaffe M
. Mitochondrial distribution and inheritance. Experientia. 1996 Dec 15; 52(12):1111-6. PMID: 8988253.
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PubMed
Zha H, Fisk HA,
Yaffe M
, Mahajan N, Herman B, Reed JC. Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol Cell Biol. 1996 Nov; 16(11):6494-508. PMID: 8887678; PMCID: PMC231651.
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PubMed
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PubMed Central
Yaffe M
, Harata D, Verde F, Eddison M, Toda T, Nurse P. Microtubules mediate mitochondrial distribution in fission yeast. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11664-8. PMID: 8876193; PMCID: PMC38115.
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PubMed
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PubMed Central
Nickas ME,
Yaffe M
. BRO1, a novel gene that interacts with components of the Pkc1p-mitogen-activated protein kinase pathway in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Jun; 16(6):2585-93. PMID: 8649366; PMCID: PMC231249.
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PubMed
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PubMed Central
Yaffe M
. Isolation and analysis of mitochondrial inheritance mutants from Saccharomyces cerevisiae. Methods Enzymol. 1995; 260:447-53. PMID: 8592466.
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PubMed
Sogo LF,
Yaffe M
. Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J Cell Biol. 1994 Sep; 126(6):1361-73. PMID: 8089171; PMCID: PMC2290945.
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PubMed Central
McConnell SJ,
Yaffe M
. Intermediate filament formation by a yeast protein essential for organelle inheritance. Science. 1993 Apr 30; 260(5108):687-9. PMID: 8480179.
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PubMed
McConnell SJ,
Yaffe M
. Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein. J Cell Biol. 1992 Jul; 118(2):385-95. PMID: 1378448; PMCID: PMC2290041.
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PubMed
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PubMed Central
Atencio DP,
Yaffe M
. MAS5, a yeast homolog of DnaJ involved in mitochondrial protein import. Mol Cell Biol. 1992 Jan; 12(1):283-91. PMID: 1729605; PMCID: PMC364104.
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PubMed Central
Smith BJ,
Yaffe M
. Uncoupling thermotolerance from the induction of heat shock proteins. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11091-4. PMID: 1763024; PMCID: PMC53079.
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PubMed Central
Stewart LC,
Yaffe M
. A role for unsaturated fatty acids in mitochondrial movement and inheritance. J Cell Biol. 1991 Dec; 115(5):1249-57. PMID: 1955472; PMCID: PMC2289227.
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Yaffe M
. Organelle inheritance in the yeast cell cycle. Trends Cell Biol. 1991 Dec; 1(6):160-4. PMID: 14731859.
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PubMed
Smith BJ,
Yaffe M
. A mutation in the yeast heat-shock factor gene causes temperature-sensitive defects in both mitochondrial protein import and the cell cycle. Mol Cell Biol. 1991 May; 11(5):2647-55. PMID: 2017170; PMCID: PMC360034.
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PubMed
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PubMed Central
Yaffe M
. Analysis of mitochondrial function and assembly. Methods Enzymol. 1991; 194:627-43. PMID: 2005813.
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PubMed
Singer SJ,
Yaffe M
. Embedded or not? Hydrophobic sequences and membranes. Trends Biochem Sci. 1990 Oct; 15(10):369-73. PMID: 2251726.
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PubMed
McConnell SJ, Stewart LC, Talin A,
Yaffe M
. Temperature-sensitive yeast mutants defective in mitochondrial inheritance. J Cell Biol. 1990 Sep; 111(3):967-76. PMID: 2202739; PMCID: PMC2116285.
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Apperson M, Jensen RE, Suda K, Witte C,
Yaffe M
. A yeast protein, homologous to the proteolipid of the chromaffin granule proton-ATPase, is important for cell growth. Biochem Biophys Res Commun. 1990 Apr 30; 168(2):574-9. PMID: 2139779.
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Yaffe M
, Jensen RE, Guido EC. The major 45-kDa protein of the yeast mitochondrial outer membrane is not essential for cell growth or mitochondrial function. J Biol Chem. 1989 Dec 15; 264(35):21091-6. PMID: 2687271.
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PubMed
Jensen RE,
Yaffe M
. Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit. EMBO J. 1988 Dec 01; 7(12):3863-71. PMID: 3061808; PMCID: PMC454965.
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Yang M, Jensen RE,
Yaffe M
, Oppliger W, Schatz G. Import of proteins into yeast mitochondria: the purified matrix processing protease contains two subunits which are encoded by the nuclear MAS1 and MAS2 genes. EMBO J. 1988 Dec 01; 7(12):3857-62. PMID: 2905264; PMCID: PMC454964.
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Witte C, Jensen RE,
Yaffe M
, Schatz G. MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease. EMBO J. 1988 May; 7(5):1439-47. PMID: 3044780; PMCID: PMC458394.
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Singer SJ, Maher PA,
Yaffe M
. On the transfer of integral proteins into membranes. Proc Natl Acad Sci U S A. 1987 Apr; 84(7):1960-4. PMID: 3470770; PMCID: PMC304561.
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Singer SJ, Maher PA,
Yaffe M
. On the translocation of proteins across membranes. Proc Natl Acad Sci U S A. 1987 Feb; 84(4):1015-9. PMID: 3469644; PMCID: PMC304352.
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Yaffe M
, Ohta S, Schatz G. A yeast mutant temperature-sensitive for mitochondrial assembly is deficient in a mitochondrial protease activity that cleaves imported precursor polypeptides. EMBO J. 1985 Aug; 4(8):2069-74. PMID: 2866092; PMCID: PMC554463.
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Yaffe M
, Schatz G. Two nuclear mutations that block mitochondrial protein import in yeast. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4819-23. PMID: 6235522; PMCID: PMC391582.
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View timeline visualization
Year
Publications
1984
1
1985
1
1987
2
1988
3
1989
1
1990
3
1991
5
1992
2
1993
1
1994
1
1995
1
1996
4
1997
3
1998
1
1999
4
2000
3
2003
3
2004
2
2006
1
2007
1
2008
2
2009
1
2012
1
2016
1
Michael's Networks
Concepts
Derived automatically from this person's publications.
Mitochondria
Saccharomyces cerevisiae
Fungal Proteins
Saccharomyces cerevisiae Proteins
Schizosaccharomyces
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Naviaux, Robert
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