Michael Karin

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Tel Aviv University, Tel Aviv, IsraelB.Sc.Biology
    University of California, Los Angeles, Los Angeles, CAPh.D.Molecular Biology
    Fox Chase Institute for Cancer Research, Philadelphia, PAPostdoctoral ScholarMolecular Biology
    University of California, San Francisco, San Francisco, CAPostdoctoral ScholarBiochemistry

    Collapse Overview 
    Collapse Overview
    Dr. Karin received his BSc in Biology from Tel Aviv University in 1975 and his Ph.D. in Molecular Biology from the University of California Los Angeles in 1979. He is currently a Distinguished Professor of Pharmacology and Pathology at the University of California San Diego School of Medicine, where he has been on the faculty since 1986. Dr. Karin has received numerous awards, including the Endocrine Society Oppenheimer Award for Excellence in 1990, American Cancer Society Research Professorship in 1999, C.E.R.I.E.S. Research Award for Physiology or Biology of the Skin in 2000, Harvey Prize in Human Health in 2011, Brupbacher Prize in Cancer Research in 2013, William B. Coley Award for Distinguished Research in Basic and Tumor Immunology in 2013, and an honorary Doctor of Medicine from the Technical University of Munich. He was a cofounder of Signal Pharmaceutical, which has become a part of Celgene, Inc. Dr. Karin had also served as a member of the National Advisory Council for Environmental Health Sciences. Dr. Karin was elected as a member of the US National Academy of Sciences in 2005, the National Academy of Medicine in 2011 and as an associate member of the European Molecular Biology Association in 2007. He became a fellow of the American Association for Cancer Research Academy in 2017. Dr. Karin’s current activity primarily focuses on understanding the relationship between inflammation, cancer, and metabolic disease as well as the signaling mechanisms used by receptors involved in inflammation and innate immunity. In addition to discovering some of the most important stress- and inflammation-responsive signal transduction pathways and establishing molecular links between obesity, inflammation and cancer, Dr. Karin’s work has revealed new targets for cancer prevention and therapy as well as for the treatment of non-alcoholic steatohepatitis (NASH) and other metabolic diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Diversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2
    NIH U54CA260591Sep 30, 2020 - Aug 31, 2022
    Role: Co-Principal Investigator
    Control of Lipogenesis and Hepatic Steatosis by Caspase-2
    NIH R01DK120714Mar 15, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Highly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitors
    NIH R01CA234128Dec 1, 2018 - Nov 30, 2023
    Role: Principal Investigator
    Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors
    NIH U01AA027681Sep 25, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Role of p62/SQSTM1 in obesity-induced liver cancer
    NIH R01CA211794Feb 15, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Organelle Disorders in Pancreatitis
    NIH P01DK098108Sep 1, 2014 - Jun 30, 2021
    Role: Co-Investigator
    The Role of IL-17 in Alcoholic Liver Disease and Cancer
    NIH U01AA022614Sep 1, 2014 - Jun 30, 2020
    Role: Principal Investigator
    IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer
    NIH R01CA163798Jul 16, 2012 - Apr 30, 2018
    Role: Principal Investigator
    TOR signaling and autophagy in obesity-promoted liver tumorigenesis
    NIH R01CA155120Jul 22, 2011 - May 31, 2016
    Role: Principal Investigator
    Pulmonary inflammation and lung cancer development and progression
    NIH R01CA132586May 5, 2008 - Apr 30, 2014
    Role: Principal Investigator
    IKK and the Control of Prostate Cancer Metastasis
    NIH R01CA127923Apr 13, 2007 - Feb 28, 2018
    Role: Principal Investigator
    Role of Inflammation in tumor promotion and progression
    NIH R01CA118165Dec 1, 2005 - Mar 31, 2017
    Role: Principal Investigator
    How Anthrax lethal factor kills macrophages
    NIH R01AI061712Jun 1, 2004 - May 31, 2010
    Role: Principal Investigator
    How Anthrax lethal factor kills activated macrophages
    NIH R21AI053528Sep 15, 2002 - Aug 31, 2005
    Role: Principal Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    NF KAPPA B REGULATION AND FUNCTION
    NIH R13CA086394Mar 14, 2000 - Mar 13, 2001
    Role: Principal Investigator
    NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation
    NIH R37AI043477Jul 1, 1998 - May 31, 2023
    Role: Principal Investigator
    Regulation of NF-kappaB and IKK by proinflammatory stimuli
    NIH R01AI043477Jul 1, 1998 - May 31, 2018
    Role: Principal Investigator
    Functions and Mechanisms of Radiation Induced Responses
    NIH R01CA076188Feb 15, 1998 - Jul 31, 2007
    Role: Principal Investigator
    Stress Signaling Pathways in Toxicity and Disease
    NIH R01ES006376Jun 1, 1993 - Jul 31, 2013
    Role: Principal Investigator
    FASEB CONFERENCE--REGULATION OF GENE EXPRESSION
    NIH R13HL046015Jul 1, 1990 - Jun 30, 1991
    Role: Principal Investigator
    FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
    NIH P01CA050528Sep 8, 1989 - Jan 31, 1998
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    TISSUE SPECIFIC EXPRESSION OF GROWTH HORMONE GENE
    NIH R01DK038527Sep 1, 1987 - Apr 30, 1999
    Role: Principal Investigator
    GENETIC AND RECEPTOR MECHANISMS IN HYPERTENSION
    NIH P01HL035018Mar 1, 1986 - Dec 31, 2009
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R37ES004151Jan 1, 1986 - Mar 31, 2009
    Role: Principal Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R01ES004151Jan 1, 1986 - Mar 31, 1998
    Role: Principal Investigator
    INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R01ES003222Jul 1, 1983 - Dec 31, 1985
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Past and Future of Inflammation as a Target to Cancer Prevention. Cancer Prev Res (Phila). 2024 Apr 02; 17(4):141-155. Antonucci L, Karin M. PMID: 38271694.
      View in: PubMed   Mentions:    Fields:    
    2. A guideline on the molecular ecosystem regulating ferroptosis. Nat Cell Biol. 2024 Feb 29. Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WS, Garcia-Saez AJ, Ioannou MS, Janowitz T, Ran Q, Gu W, Gan B, Krysko DV, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten FR, Yi Q, Schick J, Liu J, Gabrilovich DI, Liu J, Zeh HJ, Zhang DD, Yang M, Iovanna J, Kopf M, Adolph TE, Chi JT, Li C, Ichijo H, Karin M, Sankaran VG, Zou W, Galluzzi L, Bush AI, Li B, Melino G, Baehrecke EH, Lotze MT, Klionsky DJ, Stockwell BR, Kroemer G, Tang D. PMID: 38424270.
      View in: PubMed   Mentions: 1     Fields:    
    3. Cholesterol esterification and p53-mediated tumor suppression. Explor Target Antitumor Ther. 2023; 4(5):1122-1127. Li Y, Karin M, Prochownik EV. PMID: 38023993; PMCID: PMC10651352.
      View in: PubMed   Mentions:
    4. IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenance. Sci Adv. 2023 10 27; 9(43):eadg5391. Rundberg Nilsson AJS, Xian H, Shalapour S, Cammenga J, Karin M. PMID: 37889967; PMCID: PMC10610924.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC. Sci Adv. 2023 09 15; 9(37):eadh0831. Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan CL, McLennan E, Terry LV, Nobis M, Mu A, Nowell C, Horadagoda N, Henstridge DC, Mellett NA, Timpson P, Jones M, Denisenko E, Forrest ARR, Tirnitz-Parker JEE, Meikle PJ, Rose-John S, Karin M, Febbraio MA. PMID: 37703359; PMCID: PMC10499313.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Multifaceted collagen-DDR1 signaling in cancer. Trends Cell Biol. 2023 Sep 12. Su H, Karin M. PMID: 37709651; PMCID: PMC10927612.
      View in: PubMed   Mentions:    Fields:    
    7. Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development. Environ Health Perspect. 2023 09; 131(9):97001. Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts PLSM, Tukey RH, Chen S. PMID: 37668303; PMCID: PMC10478510.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Macrophage Xanthine Oxidoreductase Links LPS Induced Lung Inflammatory Injury to NLRP3 Inflammasome Expression and Mitochondrial Respiration. bioRxiv. 2023 Jul 21. Fini MA, Monks JA, Li M, Gerasimovskaya E, Paucek P, Wang K, Frid MG, Pugliese SC, Bratton D, Yu YR, Irwin D, Karin M, Wright RM, Stenmark KR. PMID: 37502951; PMCID: PMC10370167.
      View in: PubMed   Mentions:
    9. Collagen architecture and signaling orchestrate cancer development. Trends Cancer. 2023 09; 9(9):764-773. Su H, Karin M. PMID: 37400314.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Author Correction: A central role for JNK in obesity and insulin resistance. Nature. 2023 Jul; 619(7968):E25. Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. PMID: 37328696.
      View in: PubMed   Mentions:    Fields:    
    11. Signalling by senescent melanocytes hyperactivates hair growth. Nature. 2023 Jun; 618(7966):808-817. Wang X, Ramos R, Phan AQ, Yamaga K, Flesher JL, Jiang S, Oh JW, Jin S, Jahid S, Kuan CH, Nguyen TK, Liang HY, Shettigar NU, Hou R, Tran KH, Nguyen A, Vu KN, Phung JL, Ingal JP, Levitt KM, Cao X, Liu Y, Deng Z, Taguchi N, Scarfone VM, Wang G, Paolilli KN, Wang X, Guerrero-Juarez CF, Davis RT, Greenberg EN, Ruiz-Vega R, Vasudeva P, Murad R, Widyastuti LHP, Lee HL, McElwee KJ, Gadeau AP, Lawson DA, Andersen B, Mortazavi A, Yu Z, Nie Q, Kunisada T, Karin M, Tuckermann J, Esko JD, Ganesan AK, Li J, Plikus MV. PMID: 37344645; PMCID: PMC10284692.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis. Nat Commun. 2023 05 08; 14(1):2651. Sinha S, Aizawa S, Nakano Y, Rialdi A, Choi HY, Shrestha R, Pan SQ, Chen Y, Li M, Kapelanski-Lamoureux A, Yochum G, Sher L, Monga SP, Lazaris A, Machida K, Karin M, Guccione E, Tsukamoto H. PMID: 37156770; PMCID: PMC10167314.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    13. Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2300706120. Gu L, Zhu Y, Lee M, Nguyen A, Ryujin NT, Huang JY, Pandit SK, Chamseddine S, Xiao L, Mohamed YI, Kaseb AO, Karin M, Shalapour S. PMID: 37126700; PMCID: PMC10175751.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    14. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death Differ. 2023 05; 30(5):1097-1154. Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly GL, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Kluck R, Krysko DV, Kulms D, Kumar S, Lavandero S, Lavrik IN, Lemasters JJ, Liccardi G, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Luedde T, MacFarlane M, Madeo F, Malorni W, Manic G, Mantovani R, Marchi S, Marine JC, Martin SJ, Martinou JC, Mastroberardino PG, Medema JP, Mehlen P, Meier P, Melino G, Melino S, Miao EA, Moll UM, Muñoz-Pinedo C, Murphy DJ, Niklison-Chirou MV, Novelli F, Núñez G, Oberst A, Ofengeim D, Opferman JT, Oren M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pentimalli F, Pereira DM, Pervaiz S, Peter ME, Pinton P, Porta G, Prehn JHM, Puthalakath H, Rabinovich GA, Rajalingam K, Ravichandran KS, Rehm M, Ricci JE, Rizzuto R, Robinson N, Rodrigues CMP, Rotblat B, Rothlin CV, Rubinsztein DC, Rudel T, Rufini A, Ryan KM, Sarosiek KA, Sawa A, Sayan E, Schroder K, Scorrano L, Sesti F, Shao F, Shi Y, Sica GS, Silke J, Simon HU, Sistigu A, Stephanou A, Stockwell BR, Strapazzon F, Strasser A, Sun L, Sun E, Sun Q, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Troy CM, Turk B, Urbano N, Vandenabeele P, Vanden Berghe T, Vander Heiden MG, Vanderluit JL, Verkhratsky A, Villunger A, von Karstedt S, Voss AK, Vousden KH, Vucic D, Vuri D, Wagner EF, Walczak H, Wallach D, Wang R, Wang Y, Weber A, Wood W, Yamazaki T, Yang HT, Zakeri Z, Zawacka-Pankau JE, Zhang L, Zhang H, Zhivotovsky B, Zhou W, Piacentini M, Kroemer G, Galluzzi L. PMID: 37100955; PMCID: PMC10130819.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    15. Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Cell Metab. 2023 06 06; 35(6):1009-1021.e9. Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. PMID: 37084733; PMCID: PMC10430883.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    16. P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis. Hepatology. 2023 05 01; 77(5):1499-1511. Zhu Y, Gu L, Lin X, Zhou X, Lu B, Liu C, Li Y, Prochownik EV, Karin M, Wang F, Li Y. PMID: 35398929.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    17. Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential. Cell Genom. 2023 May 10; 3(5):100301. Carlessi R, Denisenko E, Boslem E, Köhn-Gaone J, Main N, Abu Bakar NDB, Shirolkar GD, Jones M, Beasley AB, Poppe D, Dwyer BJ, Jackaman C, Tjiam MC, Lister R, Karin M, Fallowfield JA, Kendall TJ, Forbes SJ, Gray ES, Olynyk JK, Yeoh G, Forrest ARR, Ramm GA, Febbraio MA, Tirnitz-Parker JEE. PMID: 37228755; PMCID: PMC10203275.
      View in: PubMed   Mentions: 2  
    18. ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. J Hepatol. 2023 08; 79(2):362-377. He F, Zhang P, Liu J, Wang R, Kaufman RJ, Yaden BC, Karin M. PMID: 36996941.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    19. Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells. bioRxiv. 2023 Mar 06. Gu L, Zhu Y, Lee M, Nguyen A, Ryujin NT, Huang J, Chamseddine S, Xiao L, Mohamed YI, Kaseb AO, Karin M, Shalapour S. PMID: 36945365; PMCID: PMC10028807.
      View in: PubMed   Mentions:
    20. IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance. bioRxiv. 2023 Mar 02. Rundberg Nilsson A, Xian H, Shalapour S, Cammenga J, Karin M. PMID: 36747722; PMCID: PMC9900858.
      View in: PubMed   Mentions:
    21. Publisher Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2023 Mar; 615(7953):E24. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36882540; PMCID: PMC10033397.
      View in: PubMed   Mentions:    Fields:    
    22. Oxidized mitochondrial DNA: a protective signal gone awry. Trends Immunol. 2023 03; 44(3):188-200. Xian H, Karin M. PMID: 36739208.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    23. Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics. Cell Death Dis. 2022 11 15; 13(11):959. Bosc E, Anastasie J, Soualmia F, Coric P, Kim JY, Wang LQ, Lacin G, Zhao K, Patel R, Duplus E, Tixador P, Sproul AA, Brugg B, Reboud-Ravaux M, Troy CM, Shelanski ML, Bouaziz S, Karin M, El Amri C, Jacotot ED. PMID: 36379916; PMCID: PMC9666555.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    24. Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis. Nature. 2022 10; 610(7931):356-365. Filliol A, Saito Y, Nair A, Dapito DH, Yu LX, Ravichandra A, Bhattacharjee S, Affo S, Fujiwara N, Su H, Sun Q, Savage TM, Wilson-Kanamori JR, Caviglia JM, Chin L, Chen D, Wang X, Caruso S, Kang JK, Amin AD, Wallace S, Dobie R, Yin D, Rodriguez-Fiallos OM, Yin C, Mehal A, Izar B, Friedman RA, Wells RG, Pajvani UB, Hoshida Y, Remotti HE, Arpaia N, Zucman-Rossi J, Karin M, Henderson NC, Tabas I, Schwabe RF. PMID: 36198802; PMCID: PMC9949942.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    25. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2022 10; 610(7931):366-372. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36198801; PMCID: PMC9588640.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    26. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Cell Metab. 2022 10 04; 34(10):1548-1560.e6. Kim JY, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M. PMID: 36041455; PMCID: PMC9547947.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    27. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Semin Liver Dis. 2022 08; 42(3):233-249. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M, Mekeel K, Schnabl B, Loomba R, Karin M, Brenner DA, Kisseleva T. PMID: 36001995; PMCID: PMC9662188.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    28. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab. 2022 08 02; 34(8):1201-1213.e5. Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KCE, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. PMID: 35921818; PMCID: PMC9365100.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    29. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun. 2022 07 27; 13(1):4346. Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. PMID: 35896521; PMCID: PMC9329322.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    30. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022 08 09; 55(8):1370-1385.e8. Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. PMID: 35835107; PMCID: PMC9378606.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    31. Diabesity? No worries, FKBP11 to the rescue. Cell Metab. 2022 07 05; 34(7):942-944. Karin M. PMID: 35793657.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    32. NF-κB: A Double-Edged Sword Controlling Inflammation. Biomedicines. 2022 May 27; 10(6). Liu D, Zhong Z, Karin M. PMID: 35740272; PMCID: PMC9219609.
      View in: PubMed   Mentions: 20  
    33. Concerted BAG3 and SIRPα blockade impairs pancreatic tumor growth. Cell Death Discov. 2022 Mar 03; 8(1):94. De Marco M, Gauttier V, Pengam S, Mary C, Ranieri B, Basile A, Festa M, Falco A, Reppucci F, Cammarota AL, Acernese F, De Laurenzi V, Sala G, Brongo S, Miyasaka M, Shalapour S, Vanhove B, Poirier N, Iaccarino R, Karin M, Turco MC, Rosati A, Marzullo L. PMID: 35241649; PMCID: PMC8894496.
      View in: PubMed   Mentions: 2  
    34. Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis. Mol Cancer Res. 2022 Mar 01; 20(3):337-349. Hanley KL, Liang Y, Wang G, Lin X, Yang M, Karin M, Fu W, Feng GS. PMID: 34810213; PMCID: PMC8898265.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    35. IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines. Proc Natl Acad Sci U S A. 2022 02 08; 119(6). Song NY, Li X, Ma B, Willette-Brown J, Zhu F, Jiang C, Su L, Shetty J, Zhao Y, Shi G, Banerjee S, Wu X, Tran B, Nussinov R, Karin M, Hu Y. PMID: 35121655; PMCID: PMC8833198.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
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    598. Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol. 1990 Apr; 10(4):1492-7. Kim SJ, Angel P, Lafyatis R, Hattori K, Kim KY, Sporn MB, Karin M, Roberts AB. PMID: 2108318; PMCID: PMC362252.
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    599. Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2710-4. Kaina B, Lohrer H, Karin M, Herrlich P. PMID: 2320583; PMCID: PMC53760.
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    600. Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity. Cell. 1990 Mar 09; 60(5):809-20. Dollé P, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M. PMID: 1690079.
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    601. Growth hormone gene regulation: a paradigm for cell-type-specific gene activation. Trends Genet. 1990 Mar; 6(3):92-6. Karin M, Castrillo JL, Theill LE. PMID: 2183418.
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    602. Too many transcription factors: positive and negative interactions. New Biol. 1990 Feb; 2(2):126-31. Karin M. PMID: 2128034.
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    603. Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases. Cell Regul. 1990 Feb; 1(3):269-78. Kim SJ, Lafyatis R, Kim KY, Angel P, Fujiki H, Karin M, Sporn MB, Roberts AB. PMID: 1966042; PMCID: PMC361469.
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    604. Tissue-specific expression of the growth hormone gene and its control by growth hormone factor-1. Recent Prog Horm Res. 1990; 46:43-57; discussion 57-8. Karin M, Theill L, Castrillo JL, McCormick A, Brady H. PMID: 2281188.
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    605. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Adv Second Messenger Phosphoprotein Res. 1990; 24:352-8. Leffert HL, Koch KS, Lu XP, Brenner DA, Karin M, Skelly HF, Rippe RA, Fey G, Chojkier M. PMID: 2169815.
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    606. Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell. 1989 Dec 22; 59(6):979-86. Chiu R, Angel P, Karin M. PMID: 2513128.
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    607. Different requirements for formation of Jun: Jun and Jun: Fos complexes. Genes Dev. 1989 Dec; 3(12B):2091-100. Smeal T, Angel P, Meek J, Karin M. PMID: 2516828.
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    608. Dissection of functional domains of the pituitary-specific transcription factor GHF-1. Nature. 1989 Dec 21-28; 342(6252):945-8. Theill LE, Castrillo JL, Wu D, Karin M. PMID: 2574416.
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    609. Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1. Science. 1989 Oct 13; 246(4927):249-51. Muegge K, Williams TM, Kant J, Karin M, Chiu R, Schmidt A, Siebenlist U, Young HA, Durum SK. PMID: 2799385.
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    610. Jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner. New Biol. 1989 Oct; 1(1):35-43. Angel P, Smeal T, Meek J, Karin M. PMID: 2518690.
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    611. The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein. Mol Cell Biol. 1989 Sep; 9(9):4091-5. Buchman C, Skroch P, Welch J, Fogel S, Karin M. PMID: 2674688; PMCID: PMC362479.
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    612. Transcription factors AP-3 and AP-2 interact with the SV40 enhancer in a mutually exclusive manner. EMBO J. 1989 May; 8(5):1455-60. Mercurio F, Karin M. PMID: 2548845; PMCID: PMC400974.
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    613. Induction of human growth hormone promoter activity by the adenosine 3',5'-monophosphate pathway involves a novel responsive element. Mol Endocrinol. 1989 May; 3(5):815-21. Dana S, Karin M. PMID: 2547155.
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    614. The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription. Oncogene. 1989 May; 4(5):629-36. Schönthal A, Büscher M, Angel P, Rahmsdorf HJ, Ponta H, Hattori K, Chiu R, Karin M, Herrlich P. PMID: 2498806.
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    615. Complexities of gene regulation by cAMP. Trends Genet. 1989 Mar; 5(3):65-7. Karin M. PMID: 2544046.
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    616. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature. 1989 Feb 16; 337(6208):661-3. Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M. PMID: 2537468.
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    617. Purification of growth hormone-specific transcription factor GHF-1 containing homeobox. Science. 1989 Feb 10; 243(4892):814-7. Castrillo JL, Bodner M, Karin M. PMID: 2563596.
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    618. Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. EMBO J. 1989 Feb; 8(2):465-73. Serfling E, Barthelmäs R, Pfeuffer I, Schenk B, Zarius S, Swoboda R, Mercurio F, Karin M. PMID: 2542017; PMCID: PMC400828.
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    619. The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein. EMBO J. 1989 Jan; 8(1):255-60. Welch J, Fogel S, Buchman C, Karin M. PMID: 2653812; PMCID: PMC400797.
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    620. Sequence-specific and general transcriptional activation by the bovine papillomavirus-1 E2 trans-activator require an N-terminal amphipathic helix-containing E2 domain. EMBO J. 1988 Dec 20; 7(13):4245-53. Haugen TH, Turek LP, Mercurio FM, Cripe TP, Olson BJ, Anderson RD, Seidl D, Karin M, Schiller J. PMID: 2854060; PMCID: PMC455138.
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    621. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell. 1988 Dec 02; 55(5):875-85. Angel P, Hattori K, Smeal T, Karin M. PMID: 3142689.
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    622. Structure and chromosomal localization of the functional intronless human JUN protooncogene. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9148-52. Hattori K, Angel P, Le Beau MM, Karin M. PMID: 3194415; PMCID: PMC282681.
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    623. The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell. 1988 Nov 04; 55(3):505-18. Bodner M, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M. PMID: 2902927.
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    624. Extinction of growth hormone expression in somatic cell hybrids involves repression of the specific trans-activator GHF-1. Cell. 1988 Oct 21; 55(2):379-89. McCormick A, Wu D, Castrillo JL, Dana S, Strobl J, Thompson EB, Karin M. PMID: 3167985.
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    625. A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1. Genes Dev. 1988 Oct; 2(10):1216-26. Hai TW, Liu F, Allegretto EA, Karin M, Green MR. PMID: 3144478.
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    626. Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element. Oncogene. 1988 Sep; 3(3):301-11. Büscher M, Rahmsdorf HJ, Litfin M, Karin M, Herrlich P. PMID: 2849742.
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    627. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell. 1988 Aug 12; 54(4):541-52. Chiu R, Boyle WJ, Meek J, Smeal T, Hunter T, Karin M. PMID: 3135940.
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    628. Progesterone induction of metallothionein-IIA gene expression. Mol Endocrinol. 1988 Jun; 2(6):485-91. Slater EP, Cato AC, Karin M, Baxter JD, Beato M. PMID: 2843758.
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    629. Cytosine methylation does not affect binding of transcription factor Sp1. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2066-70. Harrington MA, Jones PA, Imagawa M, Karin M. PMID: 3281160; PMCID: PMC279929.
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    630. Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature. 1988 Mar 10; 332(6160):166-71. Angel P, Allegretto EA, Okino ST, Hattori K, Boyle WJ, Hunter T, Karin M. PMID: 3347253.
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    631. Targets for signal-transducing protein kinases. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:131-42. Hunter T, Angel P, Boyle WJ, Chiu R, Freed E, Gould KL, Isacke CM, Karin M, Lindberg RA, van der Geer P. PMID: 3076078.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    632. In vitro activation of the HIV-1 enhancer in extracts from cells treated with a phorbol ester tumor promoter. EMBO J. 1987 Dec 20; 6(13):4067-71. Dinter H, Chiu R, Imagawa M, Karin M, Jones KA. PMID: 3443102; PMCID: PMC553889.
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    633. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell. 1987 Oct 23; 51(2):251-60. Imagawa M, Chiu R, Karin M. PMID: 2822255.
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    634. Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters. Nature. 1987 Oct 15-21; 329(6140):648-51. Chiu R, Imagawa M, Imbra RJ, Bockoven JR, Karin M. PMID: 2821407.
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    635. A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells. Cell. 1987 Jul 17; 50(2):267-75. Bodner M, Karin M. PMID: 3594572.
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    636. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell. 1987 Jun 19; 49(6):729-39. Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M. PMID: 3034432.
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    637. Metallothionein messenger RNA regulation in the mottled mouse and Menkes kinky hair syndrome. J Clin Invest. 1987 May; 79(5):1338-42. Packman S, Palmiter RD, Karin M, O'Toole C. PMID: 3571489; PMCID: PMC424381.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    638. Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor. EMBO J. 1987 Apr; 6(4):971-81. Lefevre C, Imagawa M, Dana S, Grindlay J, Bodner M, Karin M. PMID: 3595566; PMCID: PMC553491.
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    639. Metallothionein gene expression is regulated by serum factors and activators of protein kinase C. Mol Cell Biol. 1987 Apr; 7(4):1358-63. Imbra RJ, Karin M. PMID: 3600629; PMCID: PMC365221.
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    640. Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity. Mol Cell Biol. 1987 Feb; 7(2):606-13. Karin M, Haslinger A, Heguy A, Dietlin T, Cooke T. PMID: 3821726; PMCID: PMC365115.
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    641. Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene. EMBO J. 1987 Jan; 6(1):145-52. Haugen TH, Cripe TP, Ginder GD, Karin M, Turek LP. PMID: 3034572; PMCID: PMC553370.
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    642. Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature. 1987 Jan 22-28; 325(6102):368-72. Lee W, Haslinger A, Karin M, Tjian R. PMID: 3027570.
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    643. Transcriptional control mechanisms which regulate the expression of human metallothionein genes. Experientia Suppl. 1987; 52:401-5. Karin M, Haslinger A, Heguy A, Dietlin T, Imbra R. PMID: 2959529.
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    644. Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer. Nature. 1986 Oct 9-15; 323(6088):555-8. Imbra RJ, Karin M. PMID: 3020435.
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    645. Structure and tissue-specific expression of the human metallothionein IB gene. Mol Cell Biol. 1986 Jun; 6(6):2149-57. Heguy A, West A, Richards RI, Karin M. PMID: 3785191; PMCID: PMC367755.
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    646. In vivo competition between a metallothionein regulatory element and the SV40 enhancer. Science. 1986 Apr 04; 232(4746):76-80. Scholer H, Haslinger A, Heguy A, Holtgreve H, Karin M. PMID: 3006253.
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    647. Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8572-6. Haslinger A, Karin M. PMID: 3866241; PMCID: PMC390959.
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    648. Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene. Mol Cell Biol. 1985 Nov; 5(11):2984-92. Slater EP, Rabenau O, Karin M, Baxter JD, Beato M. PMID: 3018491; PMCID: PMC369110.
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    649. Interleukin 1 regulates human metallothionein gene expression. Mol Cell Biol. 1985 Oct; 5(10):2866-9. Karin M, Imbra RJ, Heguy A, Wong G. PMID: 3879767; PMCID: PMC367029.
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    650. Metallothioneins: proteins in search of function. Cell. 1985 May; 41(1):9-10. Karin M. PMID: 2581697.
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    651. Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia. Nature. 1985 Feb 21-27; 313(6004):709-11. Le Beau MM, Diaz MO, Karin M, Rowley JD. PMID: 3856101.
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    652. Tissue-specific influences affect glucocorticoid regulatory element actions on the human growth hormone gene promotor. Trans Assoc Am Physicians. 1985; 98:66-73. Slater EP, Anderson TR, Cattini PA, Eberhardt NL, Karin M, Mellon PL, Baxter JD. PMID: 3842208.
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    653. Nucleotide sequence requirements for transient expression of human metallothionein-IIA-thymidine kinase fusion genes. DNA. 1984 Aug; 3(4):319-26. Karin M, Holtgreve H. PMID: 6489094.
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    654. Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. Cell. 1984 May; 37(1):263-72. Richards RI, Heguy A, Karin M. PMID: 6327055.
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    655. Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene. Nature. 1984 Apr 5-11; 308(5959):513-9. Karin M, Haslinger A, Holtgreve H, Richards RI, Krauter P, Westphal HM, Beato M. PMID: 6323998.
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    656. The human metallothionein gene family: structure and expression. Environ Health Perspect. 1984 Mar; 54:111-5. Karin M, Richards RI. PMID: 6734550; PMCID: PMC1568162.
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    657. Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5'-flanking DNA. Cell. 1984 Feb; 36(2):371-9. Karin M, Haslinger A, Holtgreve H, Cathala G, Slater E, Baxter JD. PMID: 6692472.
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    658. Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. Proc Natl Acad Sci U S A. 1984 Jan; 81(2):337-41. Karin M, Najarian R, Haslinger A, Valenzuela P, Welch J, Fogel S. PMID: 6364141; PMCID: PMC344671.
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    659. Mechanisms of glucocorticoid hormone action. J Steroid Biochem. 1984 Jan; 20(1):77-88. Lan NC, Karin M, Nguyen T, Weisz A, Birnbaum MJ, Eberhardt NL, Baxter JD. PMID: 6368989.
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    660. Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells. DNA. 1984; 3(2):147-55. Karin M, Eberhardt NL, Mellon SH, Malich N, Richards RI, Slater EP, Barta A, Martial JA, Baxter JD, Cathala G. PMID: 6723496.
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    661. Gene amplification in yeast: CUP1 copy number regulates copper resistance. Curr Genet. 1983 Sep; 7(5):347-55. Fogel S, Welch JW, Cathala G, Karin M. PMID: 24173415.
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    662. Industrial yeasts display tandem gene iteration at the CUP1 region. Mol Cell Biol. 1983 Aug; 3(8):1353-61. Welch JW, Fogel S, Cathala G, Karin M. PMID: 6621529; PMCID: PMC369981.
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    663. Expression and regulation of a human metallothionein gene carried on an autonomously replicating shuttle vector. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):4040-4. Karin M, Cathala G, Nguyen-Huu MC. PMID: 6306660; PMCID: PMC394196.
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    664. A method for isolation of intact, translationally active ribonucleic acid. DNA. 1983; 2(4):329-35. Cathala G, Savouret JF, Mendez B, West BL, Karin M, Martial JA, Baxter JD. PMID: 6198133.
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    665. Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene. Nature. 1982 Oct 28; 299(5886):797-802. Karin M, Richards RI. PMID: 7133118.
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    666. Human metallothionein genes: molecular cloning and sequence analysis of the mRNA. Nucleic Acids Res. 1982 May 25; 10(10):3165-73. Karin M, Richards RI. PMID: 6896577; PMCID: PMC320698.
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    667. Induction of metallothionein mRNA in HeLa cells by dexamethasone and by heavy metals. Eur J Biochem. 1981 Sep 01; 118(3):527-31. Karin M, Andersen RD, Herschman HR. PMID: 7297561.
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    668. Regulation of metallothionein synthesis in HeLa cells by heavy metals and glucocorticoids. J Cell Physiol. 1981 Jan; 106(1):63-74. Karin M, Slater EP, Herschman HR. PMID: 6162854.
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    669. Induction of metallothionein in HeLa cells by dexamethasone and zinc. Eur J Biochem. 1981 Jan; 113(2):267-72. Karin M, Herschman HR. PMID: 7202410.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    670. Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response. Nature. 1980 Jul 17; 286(5770):295-7. Karin M, Andersen RD, Slater E, Smith K, Herschman HR. PMID: 7402316.
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    671. Characterization of the metallothioneins induced in HeLa cells by dexamethasone and zinc. Eur J Biochem. 1980 Jun; 107(2):395-401. Karin M, Herschman HR. PMID: 7398649.
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    672. Glucocorticoid hormone receptor mediated induction of metallothionein synthesis in HeLa cells. J Cell Physiol. 1980 Apr; 103(1):35-40. Karin M, Herschman HR. PMID: 7430258.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    673. Primary induction of metallothionein by dexamethasone in culture rat hepatocytes. Biochem Biophys Res Commun. 1980 Feb 12; 92(3):1052-69. Karin M, Herschman HR, Weinstein D. PMID: 7362599.
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    674. Dexamethasone stimulation of metallothionein synthesis in HeLa cell cultures. Science. 1979 Apr 13; 204(4389):176-7. Karin M, Herschman HR. PMID: 432639.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
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