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    Michael David

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0322
    CA La Jolla 92093
    Phone858-822-1108
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Div. of Cytokine Biology, CBER/FDA06/1996Interferons; Cytokines
      Univ. of Vienna, Vienna, AustriaPh.D.06/1991Pharmacology/Pharmacognosy
      Univ. of Vienna, Vienna, AustriaPharmD02/1989Pharmacy
      Collapse Awards and Honors
      National Multiple Sclerosis Society2014 - 2017National Multiple Sclerosis Research Award
      National Multiple Sclerosis Society2007 - 2010National Multiple Sclerosis Research Award
      National Multiple Sclerosis Society2002 - 2005National Multiple Sclerosis Research Award
      Sidney Kimmel Foundation for Cancer Research1997 - 1998Sidney Kimmel Scholar Award
      NIH1993 - 1996Fogarty Scholar Award
      Austrian Science Foundation1991 - 1992Schroedinger Award

      Collapse Research 
      Collapse Research Activities and Funding
      Generation and characterization of IRF7 conditional knockout animals
      NIH/NIAID R03AI133243Jun 8, 2017 - May 31, 2019
      Role: Principal Investigator
      The IRF-type I interferon system during gestation
      NIH/NIAID R21AI126191Mar 15, 2017 - Feb 28, 2019
      Role: Principal Investigator
      Role of TLR3 pathway in HIV infection
      NIH/NIAID R21AI127297Jun 17, 2016 - May 31, 2018
      Role: Principal Investigator
      DNA structure modification by the Schlafen protein family
      NIH/NIAID R21AI124199Mar 7, 2016 - Feb 28, 2018
      Role: Principal Investigator
      The IRF - type I interferon system in T cell-mediated immune tolerance
      NIH/NIAID R21AI105722Feb 1, 2013 - Jan 31, 2015
      Role: Principal Investigator
      Antiviral host defense through selective translational inhibition
      NIH/NIGMS R01GM101982Jun 1, 2012 - May 31, 2016
      Role: Principal Investigator
      Global innate immune responses to HIV-1 infection
      NIH P01AI090935Aug 15, 2010 - Jul 31, 2015
      Role: Co-Investigator
      Slfn proteins in innate immunity
      NIH/NIAID R21AI088490May 5, 2010 - Apr 30, 2013
      Role: Principal Investigator
      Interferon modulation of cellular microRNAs in the Hepatitis C antiviral defense
      NIH/NIDDK R01DK078857Jul 1, 2007 - Jun 30, 2012
      Role: Principal Investigator
      Interferon actions and autoimmune disorders
      NIH/NIAID R01AI071233Feb 15, 2007 - Jul 19, 2011
      Role: Principal Investigator
      Activation of Interferon Regulated Genes
      NIH/NIAID R56AI047182Apr 1, 2000 - Feb 28, 2007
      Role: Principal Investigator
      ACTIVATION OF INTERFERON REGULATED GENES
      NIH/NIAID R01AI047182Apr 1, 2000 - Feb 28, 2006
      Role: Principal Investigator
      Intracellular Signaling by Interferons
      NIH/NCI R01CA080105Jun 29, 1999 - Jun 30, 2007
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Stabell AC, Hawkins J, Li M, Gao X, David M, Press WH, Sawyer SL. Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins. PLoS Pathog. 2016 Dec; 12(12):e1006066. PMID: 28027315.
        View in: PubMed
      2. Azarian T, Daum RS, Petty LA, Steinbeck JL, Yin Z, Nolan D, Boyle-Vavra S, Hanage WP, Salemi M, David M. Intrahost Evolution of Methicillin-Resistant Staphylococcus aureus USA300 Among Individuals With Reoccurring Skin and Soft-Tissue Infections. J Infect Dis. 2016 Sep 15; 214(6):895-905. PMID: 27288537; PMCID: PMC4996148 [Available on 09/15/17].
      3. Almaden JV, Liu YC, Yang E, Otero DC, Birnbaum H, Davis-Turak J, Asagiri M, David M, Goldrath AW, Hoffmann A. B-cell survival and development controlled by the coordination of NF-?B family members RelB and cRel. Blood. 2016 Mar 10; 127(10):1276-86. PMID: 26773039.
        View in: PubMed
      4. Hemmige V, McNulty M, Silverman E, David M. Recurrent skin and soft tissue infections in HIV-infected patients during a 5-year period: incidence and risk factors in a retrospective cohort study. BMC Infect Dis. 2015 Oct 26; 15:455. PMID: 26503616; PMCID: PMC4620745.
      5. Montgomery CP, David M, Daum RS. Host factors that contribute to recurrent staphylococcal skin infection. Curr Opin Infect Dis. 2015 Jun; 28(3):253-8. PMID: 25887613; PMCID: PMC4414914.
      6. Otero DC, Fares-Frederickson NJ, Xiao M, Baker DP, David M. IFN-ß Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling. J Immunol. 2015 Jun 1; 194(11):5120-8. PMID: 25888642.
        View in: PubMed
      7. Miller LG, Eells SJ, David M, Ortiz N, Taylor AR, Kumar N, Cruz D, Boyle-Vavra S, Daum RS. Staphylococcus aureus skin infection recurrences among household members: an examination of host, behavioral, and pathogen-level predictors. Clin Infect Dis. 2015 Mar 01; 60(5):753-63. PMID: 25428411; PMCID: PMC4402346.
      8. Ohkuri T, Ghosh A, Kosaka A, Zhu J, Ikeura M, David M, Watkins SC, Sarkar SN, Okada H. STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol Res. 2014 Dec; 2(12):1199-208. PMID: 25300859; NIHMSID: NIHMS634973 [Available on 12/01/15].
        View in: PubMed
      9. Eells SJ, David M, Taylor A, Ortiz N, Kumar N, Sieth J, Boyle-Vavra S, Daum RS, Miller LG. Persistent environmental contamination with USA300 methicillin-resistant Staphylococcus aureus and other pathogenic strain types in households with S. aureus skin infections. Infect Control Hosp Epidemiol. 2014 Nov; 35(11):1373-82. PMID: 25333432.
        View in: PubMed
      10. Hemmige V, McNulty M, Silverman E, David M. Predictors of skin and soft tissue infections in HIV-infected outpatients in the community-associated methicillin-resistant Staphylococcus aureus era. Eur J Clin Microbiol Infect Dis. 2015 Feb; 34(2):339-47. PMID: 25213720.
        View in: PubMed
      11. Mowen KA, David M. Unconventional post-translational modifications in immunological signaling. Nat Immunol. 2014 May 19; 15(6):512-20. PMID: 24840982.
        View in: PubMed
      12. Abdel-Mohsen M, Raposo RA, Deng X, Li M, Liegler T, Sinclair E, Salama MS, Ghanem Hel-D, Hoh R, Wong JK, David M, Nixon DF, Deeks SG, Pillai SK. Expression profile of host restriction factors in HIV-1 elite controllers. Retrovirology. 2013; 10(1):106. PMID: 24131498.
        View in: PubMed
      13. Otero DC, Baker DP, David M. IRF7-dependent IFN-ß production in response to RANKL promotes medullary thymic epithelial cell development. J Immunol. 2013 Apr 1; 190(7):3289-98. PMID: 23440417.
        View in: PubMed
      14. Dukic VM, Lauderdale DS, Wilder J, Daum RS, David M. Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis. PLoS One. 2013; 8(1):e52722. PMID: 23300988.
        View in: PubMed
      15. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature. 2012 Nov 1; 491(7422):125-8. PMID: 23000900.
        View in: PubMed
      16. Miller LG, Eells SJ, Taylor AR, David M, Ortiz N, Zychowski D, Kumar N, Cruz D, Boyle-Vavra S, Daum RS. Staphylococcus aureus colonization among household contacts of patients with skin infections: risk factors, strain discordance, and complex ecology. Clin Infect Dis. 2012 Jun; 54(11):1523-35. PMID: 22474221.
        View in: PubMed
      17. González-Navajas JM, Lee J, David M, Raz E. Immunomodulatory functions of type I interferons. Nat Rev Immunol. 2012 Feb; 12(2):125-35. PMID: 22222875.
        View in: PubMed
      18. Chiang CY, Veckman V, Limmer K, David M. Phospholipase C?-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like receptor 4 (TLR4) endocytosis and interferon regulatory factor 3 (IRF3) activation. J Biol Chem. 2012 Feb 3; 287(6):3704-9. PMID: 22158869.
        View in: PubMed
      19. Moro H, Otero DC, Tanabe Y, David M. T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival. PLoS One. 2011; 6(9):e24972. PMID: 21949815.
        View in: PubMed
      20. David M. Interferons and microRNAs. J Interferon Cytokine Res. 2010 Nov; 30(11):825-8. PMID: 20939680.
        View in: PubMed
      21. Pedersen IM, Otero D, Kao E, Miletic AV, Hother C, Ralfkiaer E, Rickert RC, Gronbaek K, David M. Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas. EMBO Mol Med. 2009 Aug; 1(5):288-95. PMID: 19890474.
        View in: PubMed
      22. Pedersen I, David M. MicroRNAs in the immune response. Cytokine. 2008 Sep; 43(3):391-4. PMID: 18701320.
        View in: PubMed
      23. Pedersen IM, Cheng G, Wieland S, Volinia S, Croce CM, Chisari FV, David M. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature. 2007 Oct 18; 449(7164):919-22. PMID: 17943132.
        View in: PubMed
      24. Kolla RV, Chintalapati S, Sabet M, Santelli E, Liddington RC, David M, Fierer J, Guiney D, Rickert RC. Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response. PLoS One. 2007; 2(10):e1044. PMID: 17940608.
        View in: PubMed
      25. Hoyt R, Zhu W, Cerignoli F, Alonso A, Mustelin T, David M. Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. J Immunol. 2007 Sep 15; 179(6):3402-6. PMID: 17785772.
        View in: PubMed
      26. Otero DC, Poli V, David M, Rickert RC. Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. J Immunol. 2006 Nov 15; 177(10):6593-7. PMID: 17082570.
        View in: PubMed
      27. Chiang E, Dang O, Anderson K, Matsuzawa A, Ichijo H, David M. Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. J Immunol. 2006 May 15; 176(10):5720-4. PMID: 16670275.
        View in: PubMed
      28. Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass CK. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 2005 Sep 9; 122(5):707-21. PMID: 16143103.
        View in: PubMed
      29. Tanabe Y, Nishibori T, Su L, Arduini RM, Baker DP, David M. Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes. J Immunol. 2005 Jan 15; 174(2):609-13. PMID: 15634877.
        View in: PubMed
      30. Li S, Wilkinson M, Xia X, David M, Xu L, Purkel-Sutton A, Bhardwaj A. Induction of IFN-regulated factors and antitumoral surveillance by transfected placebo plasmid DNA. Mol Ther. 2005 Jan; 11(1):112-9. PMID: 15585412.
        View in: PubMed
      31. Mowen KA, Schurter BT, Fathman JW, David M, Glimcher LH. Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mol Cell. 2004 Aug 27; 15(4):559-71. PMID: 15327772.
        View in: PubMed
      32. Dang O, Navarro L, David M. Inhibition of lipopolysaccharide-induced interferon regulatory factor 3 activation and protection from septic shock by hydroxystilbenes. Shock. 2004 May; 21(5):470-5. PMID: 15087825.
        View in: PubMed
      33. Cheng HY, Li P, David M, Smithgall TE, Feng L, Lieberman MW. Arsenic inhibition of the JAK-STAT pathway. Oncogene. 2004 Apr 29; 23(20):3603-12. PMID: 15116095.
        View in: PubMed
      34. Smith WA, Schurter BT, Wong-Staal F, David M. Arginine methylation of RNA helicase a determines its subcellular localization. J Biol Chem. 2004 May 28; 279(22):22795-8. PMID: 15084609.
        View in: PubMed
      35. Dang O, Navarro L, Anderson K, David M. Cutting edge: anthrax lethal toxin inhibits activation of IFN-regulatory factor 3 by lipopolysaccharide. J Immunol. 2004 Jan 15; 172(2):747-51. PMID: 14707042.
        View in: PubMed
      36. Nishibori T, Tanabe Y, Su L, David M. Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J Exp Med. 2004 Jan 5; 199(1):25-34. PMID: 14699080.
        View in: PubMed
      37. Ruvolo V, Navarro L, Sample CE, David M, Sung S, Swaminathan S. The Epstein-Barr virus SM protein induces STAT1 and interferon-stimulated gene expression. J Virol. 2003 Mar; 77(6):3690-701. PMID: 12610144.
        View in: PubMed
      38. David M. Signal transduction by type I interferons. Biotechniques. 2002 Oct; Suppl:58-65. PMID: 12395928.
        View in: PubMed
      39. Zhu W, Mustelin T, David M. Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase. J Biol Chem. 2002 Sep 27; 277(39):35787-90. PMID: 12171910.
        View in: PubMed
      40. ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y, Zhu W, Tremblay M, David M, Shuai K. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol. 2002 Aug; 22(16):5662-8. PMID: 12138178.
        View in: PubMed
      41. Blesofsky WA, Mowen K, Arduini RM, Baker DP, Murphy MA, Bowtell DD, David M. Regulation of STAT protein synthesis by c-Cbl. Oncogene. 2001 Nov 1; 20(50):7326-33. PMID: 11704862.
        View in: PubMed
      42. Mowen KA, David M. Analysis of protein arginine methylation and protein arginine-methyltransferase activity. Sci STKE. 2001 Jul 31; 2001(93):pl1. PMID: 11752667.
        View in: PubMed
      43. Mowen KA, Tang J, Zhu W, Schurter BT, Shuai K, Herschman HR, David M. Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell. 2001 Mar 9; 104(5):731-41. PMID: 11257227.
        View in: PubMed
      44. Mowen KA, David M. Cytokine activation of transcription. Genet Eng (N Y). 2001; 23:35-44. PMID: 11570105.
        View in: PubMed
      45. Mowen K, David M. Regulation of STAT1 nuclear export by Jak1. Mol Cell Biol. 2000 Oct; 20(19):7273-81. PMID: 10982844.
        View in: PubMed
      46. Su L, David M. Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol. J Biol Chem. 2000 Apr 28; 275(17):12661-6. PMID: 10777558.
        View in: PubMed
      47. Navarro L, David M. p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide. J Biol Chem. 1999 Dec 10; 274(50):35535-8. PMID: 10585427.
        View in: PubMed
      48. Su L, Rickert RC, David M. Rapid STAT phosphorylation via the B cell receptor. Modulatory role of CD19. J Biol Chem. 1999 Nov 5; 274(45):31770-4. PMID: 10542198.
        View in: PubMed
      49. Su L, David M. Inhibition of B cell receptor-mediated apoptosis by IFN. J Immunol. 1999 Jun 1; 162(11):6317-21. PMID: 10352242.
        View in: PubMed
      50. Mowen K, David M. Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J Biol Chem. 1998 Nov 13; 273(46):30073-6. PMID: 9804758.
        View in: PubMed
      51. Navarro L, Mowen K, Rodems S, Weaver B, Reich N, Spector D, David M. Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex. Mol Cell Biol. 1998 Jul; 18(7):3796-802. PMID: 9632763.
        View in: PubMed