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    Michael Burkart

    TitleTeacher
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0358
    CA La Jolla 92093
    Phone858-534-5673
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Single cell enzymatic discovery and antibiotic targeting
      NIH/NIAID R21AI134037Jul 19, 2017 - Jun 30, 2019
      Role: Principal Investigator
      Chemical Biology Interfaces at UC San Diego
      NIH/NIGMS T32GM112584Jul 1, 2015 - Jun 30, 2020
      Role: Principal Investigator
      Very long chain fatty acid biosynthesis in Mycobacterium tuberculosis
      NIH/NIAID R21AI117777Jul 1, 2015 - Jun 30, 2017
      Role: Principal Investigator
      Protein-Protein Interaction in Natural Product Biosynthesis
      NIH/NIGMS R01GM095970Mar 1, 2012 - Jan 31, 2020
      Role: Principal Investigator
      The Molecular Basis of Regio-Specificity in Fungal Polyketide Synthase
      NIH/NIGMS R01GM100305Feb 1, 2012 - Jan 31, 2016
      Role: Principal Investigator
      OASIS to identify and analyze natural product biosynthesis
      NIH/NIGMS R01GM094924Sep 1, 2010 - Aug 31, 2014
      Role: Principal Investigator
      Discovery of antitubercular PptT inhibitors
      NIH/NIAID R21AI090213Jul 1, 2010 - Jun 30, 2012
      Role: Principal Investigator
      Site Specific Protein Labeling In Vivo Through Genetically Engineered Phosphopant
      NIH/NIGMS R01GM086225Sep 30, 2008 - Oct 31, 2012
      Role: Principal Investigator
      A qHTS FRET-Quench Assay for 4?-Phosphopantethienyltransferases
      NIH/NIMH R03MH083266Sep 29, 2007 - Aug 31, 2009
      Role: Principal Investigator
      Proteomic methodologies for polyketide biosynthesis (RMI)
      NIH/NIGMS R01GM075797Sep 23, 2005 - Jul 31, 2010
      Role: Principal Investigator
      HALOGENATION IN PEPTIDE ANTIBIOTIC BIOSYNTHESIS
      NIH/NIAID F32AI010507Apr 1, 2000
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Jaremko MJ, Lee DJ, Patel A, Winslow V, Opella SJ, McCammon JA, Burkart M. Manipulating Protein-Protein Interactions in Nonribosomal Peptide Synthetase Type II Peptidyl Carrier Proteins. Biochemistry. 2017 Oct 02. PMID: 28920687.
        View in: PubMed
      2. León B, Kashyap MK, Chan WC, Krug KA, Castro JE, La Clair JJ, Burkart M. A Challenging Pie to Splice: Drugging the Spliceosome. Angew Chem Int Ed Engl. 2017 Sep 25; 56(40):12052-12063. PMID: 28371109.
        View in: PubMed
      3. Barajas JF, Shakya G, Moreno G, Rivera H, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart M, Tsai SC. Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proc Natl Acad Sci U S A. 2017 May 23; 114(21):E4142-E4148. PMID: 28484029.
        View in: PubMed
      4. Mindrebo JT, Nartey CM, Seto Y, Burkart M, Noel JP. Corrigendum to "Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom" [Curr Opin Struct Biol 2016, 41:233-246]. Curr Opin Struct Biol. 2016 Dec; 41:256-257. PMID: 27884574.
        View in: PubMed
      5. Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart M, Tsai SC. Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain. Angew Chem Int Ed Engl. 2016 Oct 10; 55(42):13005-13009. PMID: 27653519.
        View in: PubMed
      6. Shurin JB, Burkart M, Mayfield SP, Smith VH. Recent progress and future challenges in algal biofuel production. F1000Res. 2016; 5. PMID: 27781084.
        View in: PubMed
      7. Mindrebo JT, Nartey CM, Seto Y, Burkart M, Noel JP. Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom. Curr Opin Struct Biol. 2016 Dec; 41:233-246. PMID: 27662376.
        View in: PubMed
      8. Crews LA, Balaian L, Delos Santos NP, Leu HS, Court AC, Lazzari E, Sadarangani A, Zipeto MA, La Clair JJ, Villa R, Kulidjian A, Storb R, Morris SR, Ball ED, Burkart M, Jamieson CH. RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell. 2016 Nov 03; 19(5):599-612. PMID: 27570067.
        View in: PubMed
      9. Kumar D, Kashyap MK, La Clair JJ, Villa R, Spaanderman I, Chien S, Rassenti LZ, Kipps TJ, Burkart M, Castro JE. Selectivity in Small Molecule Splicing Modulation. ACS Chem Biol. 2016 Oct 21; 11(10):2716-2723. PMID: 27499047.
        View in: PubMed
      10. McCulloch IP, La Clair JJ, Jaremko MJ, Burkart M. Fluorescent Mechanism-Based Probe for Aerobic Flavin-Dependent Enzyme Activity. Chembiochem. 2016 Sep 02; 17(17):1598-601. PMID: 27271974.
        View in: PubMed
      11. Foley TL, Dorjsuren D, Dexheimer TS, Burkart M, Wight WC, Simeonov A. A Platform to Enable the Pharmacological Profiling of Small Molecules in Gel-Based Electrophoretic Mobility Shift Assays. J Biomol Screen. 2016 Dec; 21(10):1125-1131. PMID: 27269812.
        View in: PubMed
      12. Rivera H, Dhar S, La Clair JJ, Tsai SC, Burkart M. An unusual intramolecular trans-amidation. Tetrahedron. 2016 Jun 23; 72(25):3605-3608. PMID: 27346894.
        View in: PubMed
      13. Koo HJ, Vickery CR, Xu Y, Louie GV, O'Maille PE, Bowman M, Nartey CM, Burkart M, Noel JP. Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants. J Antibiot (Tokyo). 2016 Jul; 69(7):524-33. PMID: 27328867.
        View in: PubMed
      14. Vranken C, Fin A, Tufar P, Hofkens J, Burkart M, Tor Y. Chemoenzymatic synthesis and utilization of a SAM analog with an isomorphic nucleobase. Org Biomol Chem. 2016 Jul 14; 14(26):6189-92. PMID: 27270873; PMCID: PMC4927405 [Available on 07/14/17].
      15. Uranga CC, Beld J, Mrse A, Córdova-Guerrero I, Burkart M, Hernández-Martínez R. Data from mass spectrometry, NMR spectra, GC-MS of fatty acid esters produced by Lasiodiplodia theobromae. Data Brief. 2016 Sep; 8:31-9. PMID: 27274528; PMCID: PMC4885019.
      16. Dhar S, La Clair JJ, León B, Hammons JC, Yu Z, Kashyap MK, Castro JE, Burkart M. A Carbohydrate-Derived Splice Modulator. J Am Chem Soc. 2016 Apr 20; 138(15):5063-8. PMID: 27058259.
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      17. Tallorin L, Finzel K, Nguyen QG, Beld J, La Clair JJ, Burkart M. Trapping of the Enoyl-Acyl Carrier Protein Reductase-Acyl Carrier Protein Interaction. J Am Chem Soc. 2016 Mar 30; 138(12):3962-5. PMID: 26938266; PMCID: PMC4988885.
      18. Uranga CC, Beld J, Mrse A, Córdova-Guerrero I, Burkart M, Hernández-Martínez R. Fatty acid esters produced by Lasiodiplodia theobromae function as growth regulators in tobacco seedlings. Biochem Biophys Res Commun. 2016 Apr 01; 472(2):339-45. PMID: 26926564.
        View in: PubMed
      19. Beld J, Abbriano R, Finzel K, Hildebrand M, Burkart M. Probing fatty acid metabolism in bacteria, cyanobacteria, green microalgae and diatoms with natural and unnatural fatty acids. Mol Biosyst. 2016 Apr; 12(4):1299-312. PMID: 26886879.
        View in: PubMed
      20. Vickery CR, La Clair JJ, Burkart M, Noel JP. Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products. Curr Opin Chem Biol. 2016 Apr; 31:66-73. PMID: 26851514.
        View in: PubMed
      21. Finzel K, Burkart M. Traffic Control in Modular Polyketide Synthases. ACS Cent Sci. 2016 Jan 27; 2(1):9-11. PMID: 27163020; PMCID: PMC4827489.
      22. Patterson JP, Collins DB, Michaud JM, Axson JL, Sultana CM, Moser T, Dommer AC, Conner J, Grassian VH, Stokes MD, Deane GB, Evans JE, Burkart M, Prather KA, Gianneschi NC. Sea Spray Aerosol Structure and Composition Using Cryogenic Transmission Electron Microscopy. ACS Cent Sci. 2016 Jan 27; 2(1):40-47. PMID: 26878061.
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      23. Moynié L, Hope AG, Finzel K, Schmidberger J, Leckie SM, Schneider G, Burkart M, Smith AD, Gray DW, Naismith JH. A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA. J Mol Biol. 2016 Jan 16; 428(1):108-120. PMID: 26562505; PMCID: PMC4840175.
      24. Finzel K, Nguyen C, Jackson DR, Gupta A, Tsai SC, Burkart M. Probing the Substrate Specificity and Protein-Protein Interactions of the E. coli Fatty Acid Dehydratase, FabA. Chem Biol. 2015 Nov 19; 22(11):1453-1460. PMID: 26526101; PMCID: PMC4656083 [Available on 11/19/16].
      25. Jaremko MJ, Lee DJ, Opella SJ, Burkart M. Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL. J Am Chem Soc. 2015 Sep 16; 137(36):11546-9. PMID: 26340431; PMCID: PMC4847951.
      26. Cahill JF, Darlington TK, Fitzgerald C, Schoepp NG, Beld J, Burkart M, Prather KA. Online analysis of single cyanobacteria and algae cells under nitrogen-limited conditions using aerosol time-of-flight mass spectrometry. Anal Chem. 2015 Aug 18; 87(16):8039-46. PMID: 26237223.
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      27. Ferreira-Camargo LS, Tran M, Beld J, Burkart M, Mayfield SP. Selenocystamine improves protein accumulation in chloroplasts of eukaryotic green algae. AMB Express. 2015 Dec; 5(1):126. PMID: 26137911; PMCID: PMC4489976.
      28. Lin L, Nonejuie P, Munguia J, Hollands A, Olson J, Dam Q, Kumaraswamy M, Rivera H, Corriden R, Rohde M, Hensler ME, Burkart M, Pogliano J, Sakoulas G, Nizet V. Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens. EBioMedicine. 2015 Jul; 2(7):690-8. PMID: 26288841; PMCID: PMC4534682.
      29. Kashyap MK, Kumar D, Villa R, La Clair JJ, Benner C, Sasik R, Jones H, Ghia EM, Rassenti LZ, Kipps TJ, Burkart M, Castro JE. Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B. Haematologica. 2015 Jul; 100(7):945-54. PMID: 25862704; PMCID: PMC4486229.
      30. Konno S, Ishikawa F, Suzuki T, Dohmae N, Burkart M, Kakeya H. Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases. Chem Commun (Camb). 2015 Feb 11; 51(12):2262-5. PMID: 25563804; PMCID: PMC4795001.
      31. Ku TH, Sahu S, Kosa NM, Pham KM, Burkart M, Gianneschi NC. Tapping a bacterial enzymatic pathway for the preparation and manipulation of synthetic nanomaterials. J Am Chem Soc. 2014 Dec 17; 136(50):17378-81. PMID: 25468257.
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      32. Shakya G, Rivera H, Lee DJ, Jaremko MJ, La Clair JJ, Fox DT, Haushalter RW, Schaub AJ, Bruegger J, Barajas JF, White AR, Kaur P, Gwozdziowski ER, Wong F, Tsai SC, Burkart M. Modeling linear and cyclic PKS intermediates through atom replacement. J Am Chem Soc. 2014 Dec 03; 136(48):16792-9. PMID: 25406716; PMCID: PMC4277753.
      33. Beld J, Lee DJ, Burkart M. Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering. Mol Biosyst. 2015 Jan; 11(1):38-59. PMID: 25360565; PMCID: PMC4276719.
      34. Beld J, Cang H, Burkart M. Visualizing the chain-flipping mechanism in fatty-acid biosynthesis. Angew Chem Int Ed Engl. 2014 Dec 22; 53(52):14456-61. PMID: 25354391; PMCID: PMC4425425.
      35. Lindert S, Tallorin L, Nguyen QG, Burkart M, McCammon JA. In silico screening for Plasmodium falciparum enoyl-ACP reductase inhibitors. J Comput Aided Mol Des. 2015 Jan; 29(1):79-87. PMID: 25344312; PMCID: PMC4278936.
      36. Beld J, Finzel K, Burkart M. Versatility of acyl-acyl carrier protein synthetases. Chem Biol. 2014 Oct 23; 21(10):1293-1299. PMID: 25308274; PMCID: PMC4224610.
      37. Beld J, Blatti JL, Behnke C, Mendez M, Burkart M. Evolution of acyl-ACP-thioesterases and ß-ketoacyl-ACP-synthases revealed by protein-protein interactions. J Appl Phycol. 2014 Aug 01; 26(4):1619-1629. PMID: 25110394.
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      38. Vickery CR, Kosa NM, Casavant EP, Duan S, Noel JP, Burkart M. Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of Mycobacteria. ACS Chem Biol. 2014 Sep 19; 9(9):1939-44. PMID: 24963544; PMCID: PMC4168790.
      39. Schoepp NG, Stewart RL, Sun V, Quigley AJ, Mendola D, Mayfield SP, Burkart M. System and method for research-scale outdoor production of microalgae and cyanobacteria. Bioresour Technol. 2014 Aug; 166:273-81. PMID: 24926599.
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      40. Foley TL, Rai G, Yasgar A, Daniel T, Baker HL, Attene-Ramos M, Kosa NM, Leister W, Burkart M, Jadhav A, Simeonov A, Maloney DJ. 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth. J Med Chem. 2014 Feb 13; 57(3):1063-78. PMID: 24450337; PMCID: PMC3983359.
      41. Kosa NM, Pham KM, Burkart M. Chemoenzymatic exchange of phosphopantetheine on protein and peptide. Chem Sci. 2014 Mar 01; 5(3):1179-1186. PMID: 26998215.
        View in: PubMed
      42. Rothmann M, Kosa NM, Burkart M. Resin supported acyl carrier protein labeling strategies. RSC Adv. 2014; 4(18):9092-9097. PMID: 24818001.
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      43. Beld J, Sonnenschein EC, Vickery CR, Noel JP, Burkart M. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life. Nat Prod Rep. 2014 Jan; 31(1):61-108. PMID: 24292120; PMCID: PMC3918677.
      44. Nguyen C, Haushalter RW, Lee DJ, Markwick PR, Bruegger J, Caldara-Festin G, Finzel K, Jackson DR, Ishikawa F, O'Dowd B, McCammon JA, Opella SJ, Tsai SC, Burkart M. Trapping the dynamic acyl carrier protein in fatty acid biosynthesis. Nature. 2014 Jan 16; 505(7483):427-31. PMID: 24362570; PMCID: PMC4437705.
      45. Thomsen M, Vogensen SB, Buchardt J, Burkart M, Clausen RP. Chemoenzymatic synthesis and in situ application of S-adenosyl-L-methionine analogs. Org Biomol Chem. 2013 Nov 21; 11(43):7606-10. PMID: 24100405; PMCID: PMC3871182.
      46. Kosa NM, Foley TL, Burkart M. Fluorescent techniques for discovery and characterization of phosphopantetheinyl transferase inhibitors. J Antibiot (Tokyo). 2014 Jan; 67(1):113-20. PMID: 24192555; PMCID: PMC4807864.
      47. Nonejuie P, Burkart M, Pogliano K, Pogliano J. Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):16169-74. PMID: 24046367; PMCID: PMC3791758.
      48. Javidpour P, Bruegger J, Srithahan S, Korman TP, Crump MP, Crosby J, Burkart M, Tsai SC. The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase. Chem Biol. 2013 Oct 24; 20(10):1225-34. PMID: 24035284; PMCID: PMC3855848.
      49. Bruegger J, Haushalter RW, Haushalter B, Vagstad AL, Vagstad A, Shakya G, Mih N, Townsend CA, Burkart M, Tsai SC. Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chem Biol. 2013 Sep 19; 20(9):1135-46. PMID: 23993461; PMCID: PMC3796367.
      50. Villa R, Kashyap MK, Kumar D, Kipps TJ, Castro JE, La Clair JJ, Burkart M. Stabilized cyclopropane analogs of the splicing inhibitor FD-895. J Med Chem. 2013 Sep 12; 56(17):6576-82. PMID: 23919277; PMCID: PMC3809018.
      51. Ishikawa F, Haushalter RW, Lee DJ, Finzel K, Burkart M. Sulfonyl 3-alkynyl pantetheinamides as mechanism-based cross-linkers of acyl carrier protein dehydratase. J Am Chem Soc. 2013 Jun 19; 135(24):8846-9. PMID: 23718183; PMCID: PMC3713789.
      52. Burkart M, Mayfield SP. Biofuels for the 21st century. Curr Opin Chem Biol. 2013 Jun; 17(3):436-8. PMID: 23722079.
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      53. Blatti JL, Michaud J, Burkart M. Engineering fatty acid biosynthesis in microalgae for sustainable biodiesel. Curr Opin Chem Biol. 2013 Jun; 17(3):496-505. PMID: 23683348.
        View in: PubMed
      54. Yu WL, Jones BD, Kang M, Hammons JC, La Clair JJ, Burkart M. Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF). J Nat Prod. 2013 May 24; 76(5):817-23. PMID: 23659282; PMCID: PMC3706094.
      55. Lipson JM, Thomsen M, Moore BS, Clausen RP, La Clair JJ, Burkart M. A tandem chemoenzymatic methylation by S-adenosyl-L-methionine. Chembiochem. 2013 May 27; 14(8):950-3. PMID: 23650044; PMCID: PMC3749784.
      56. Rothmann M, Kang M, Villa R, Ntai I, La Clair JJ, Kelleher NL, Chapman E, Burkart M. Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. J Am Chem Soc. 2013 Apr 24; 135(16):5962-5. PMID: 23550886; PMCID: PMC3657554.
      57. Stewart C, Vickery CR, Burkart M, Noel JP. Confluence of structural and chemical biology: plant polyketide synthases as biocatalysts for a bio-based future. Curr Opin Plant Biol. 2013 Jun; 16(3):365-72. PMID: 23481348.
        View in: PubMed
      58. Rodionova IA, Leyn SA, Burkart M, Boucher N, Noll KM, Osterman AL, Rodionov DA. Novel inositol catabolic pathway in Thermotoga maritima. Environ Microbiol. 2013 Aug; 15(8):2254-66. PMID: 23441918.
        View in: PubMed
      59. Villa R, Mandel AL, Jones BD, La Clair JJ, Burkart M. Structure of FD-895 revealed through total synthesis. Org Lett. 2012 Nov 02; 14(21):5396-9. PMID: 23072504; PMCID: PMC3518397.
      60. Kosa NM, Haushalter RW, Smith AR, Burkart M. Reversible labeling of native and fusion-protein motifs. Nat Methods. 2012 Oct; 9(10):981-4. PMID: 22983458; PMCID: PMC4128096.
      61. Blatti JL, Beld J, Behnke CA, Mendez M, Mayfield SP, Burkart M. Manipulating fatty acid biosynthesis in microalgae for biofuel through protein-protein interactions. PLoS One. 2012; 7(9):e42949. PMID: 23028438; PMCID: PMC3441505.
      62. Hur GH, Vickery CR, Burkart M. Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology. Nat Prod Rep. 2012 Oct; 29(10):1074-98. PMID: 22802156; PMCID: PMC4807874.
      63. van der Westhuyzen R, Hammons JC, Meier JL, Dahesh S, Moolman WJ, Pelly SC, Nizet V, Burkart M, Strauss E. The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis. Chem Biol. 2012 May 25; 19(5):559-71. PMID: 22633408; PMCID: PMC3361698.
      64. Ishikawa F, Haushalter RW, Burkart M. Dehydratase-specific probes for fatty acid and polyketide synthases. J Am Chem Soc. 2012 Jan 18; 134(2):769-72. PMID: 22188524; PMCID: PMC3269962.
      65. Yu WL, Ansari W, Schoepp NG, Hannon MJ, Mayfield SP, Burkart M. Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae. Microb Cell Fact. 2011 Nov 02; 10:91. PMID: 22047615; PMCID: PMC3234195.
      66. Rothmann M, Niessen S, Haushalter RW, Cravatt BF, Burkart M. Resin-based investigation of acyl carrier protein interaction networks in Escherichia coli. Bioorg Med Chem. 2012 Jan 15; 20(2):667-71. PMID: 22104437; PMCID: PMC3809020.
      67. La Clair JJ, Rheingold AL, Burkart M. Ganodone, a bioactive benzofuran from the fruiting bodies of Ganoderma tsugae. J Nat Prod. 2011 Oct 28; 74(10):2045-51. PMID: 21939217.
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      68. Jones AC, Monroe EA, Podell S, Hess WR, Klages S, Esquenazi E, Niessen S, Hoover H, Rothmann M, Lasken RS, Yates JR, Reinhardt R, Kube M, Burkart M, Allen EE, Dorrestein PC, Gerwick WH, Gerwick L. Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8815-20. PMID: 21555588; PMCID: PMC3102346.
      69. Haushalter RW, Filipp FV, Ko KS, Yu R, Opella SJ, Burkart M. Binding and "pKa" modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein. ACS Chem Biol. 2011 May 20; 6(5):413-8. PMID: 21268653; PMCID: PMC3092034.
      70. Worthington AS, Hur GH, Burkart M. Activity-guided engineering of natural product carrier proteins. Mol Biosyst. 2011 Feb; 7(2):365-70. PMID: 21184004.
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      71. Meier JL, Patel AD, Niessen S, Meehan M, Kersten R, Yang JY, Rothmann M, Cravatt BF, Dorrestein PC, Burkart M, Bafna V. Practical 4'-phosphopantetheine active site discovery from proteomic samples. J Proteome Res. 2011 Jan 07; 10(1):320-9. PMID: 21067235; PMCID: PMC3042426.
      72. Meier JL, Burkart M. Proteomic analysis of polyketide and nonribosomal peptide biosynthesis. Curr Opin Chem Biol. 2011 Feb; 15(1):48-56. PMID: 21087894; PMCID: PMC3050567.
      73. Jones BD, La Clair JJ, Moore CE, Rheingold AL, Burkart M. Convergent route to the spirohexenolide macrocycle. Org Lett. 2010 Oct 15; 12(20):4516-9. PMID: 20849075; PMCID: PMC2956428.
      74. Reyes CP, La Clair JJ, Burkart M. Metabolic probes for imaging endosymbiotic bacteria within toxic dinoflagellates. Chem Commun (Camb). 2010 Nov 21; 46(43):8151-3. PMID: 20927429.
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      75. Yu WL, Guizzunti G, Foley TL, Burkart M, La Clair JJ. An optimized immunoaffinity fluorescent method for natural product target elucidation. J Nat Prod. 2010 Oct 22; 73(10):1659-66. PMID: 20836515.
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      76. Foley TL, Yasgar A, Garcia CJ, Jadhav A, Simeonov A, Burkart M. Preparation of FRET reporters to support chemical probe development. Org Biomol Chem. 2010 Oct 21; 8(20):4601-6. PMID: 20725690; PMCID: PMC2948233.
      77. Ko KS, Alexander MD, Fontaine SD, Biggs-Houck JE, La Clair JJ, Burkart M. Synthetic studies on the mycolactone core. Org Biomol Chem. 2010 Nov 21; 8(22):5159-65. PMID: 20844795.
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      78. Meier JL, Haushalter RW, Burkart M. A mechanism based protein crosslinker for acyl carrier protein dehydratases. Bioorg Med Chem Lett. 2010 Aug 15; 20(16):4936-9. PMID: 20620055; PMCID: PMC2956584.
      79. Worthington AS, Porter DF, Burkart M. Mechanism-based crosslinking as a gauge for functional interaction of modular synthases. Org Biomol Chem. 2010 Apr 21; 8(8):1769-72. PMID: 20449476.
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      80. Kang M, Jones BD, Mandel AL, Hammons JC, DiPasquale AG, Rheingold AL, La Clair JJ, Burkart M. Isolation, structure elucidation, and antitumor activity of spirohexenolides A and B. J Org Chem. 2009 Dec 04; 74(23):9054-61. PMID: 19883063.
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      81. Meier JL, Niessen S, Hoover HS, Foley TL, Cravatt BF, Burkart M. An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis. ACS Chem Biol. 2009 Nov 20; 4(11):948-57. PMID: 19785476; PMCID: PMC2818308.
      82. Foley TL, Young BS, Burkart M. Phosphopantetheinyl transferase inhibition and secondary metabolism. FEBS J. 2009 Dec; 276(23):7134-45. PMID: 19895578.
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      83. Lear MJ, Simon O, Foley TL, Burkart M, Baiga TJ, Noel JP, DiPasquale AG, Rheingold AL, La Clair JJ. Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. J Nat Prod. 2009 Nov; 72(11):1980-7. PMID: 19842686.
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      84. Yasgar A, Foley TL, Jadhav A, Inglese J, Burkart M, Simeonov A. A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase. Mol Biosyst. 2010 Feb; 6(2):365-75. PMID: 20094656; PMCID: PMC2992954.
      85. Foley TL, Burkart M. A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase. Anal Biochem. 2009 Nov 01; 394(1):39-47. PMID: 19573516; PMCID: PMC2761036.
      86. Mercer AC, Meier JL, Torpey JW, Burkart M. In vivo modification of native carrier protein domains. Chembiochem. 2009 Apr 17; 10(6):1091-100. PMID: 19308927; PMCID: PMC2767527.
      87. Hur GH, Meier JL, Baskin J, Codelli JA, Bertozzi CR, Marahiel MA, Burkart M. Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis. Chem Biol. 2009 Apr 24; 16(4):372-81. PMID: 19345117; PMCID: PMC2743379.
      88. Meier JL, Burkart M. The chemical biology of modular biosynthetic enzymes. Chem Soc Rev. 2009 Jul; 38(7):2012-45. PMID: 19551180.
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      89. Najmabadi P, Lee HH, Aung T, Thuya A, Ng J, La Clair JJ, Burkart M. Grafta: a 3D environment for biomolecular networks. Int J Bioinform Res Appl. 2009; 5(5):564-9. PMID: 19778870.
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      90. Meier JL, Burkart M. Chapter 9. Synthetic probes for polyketide and nonribosomal peptide biosynthetic enzymes. Methods Enzymol. 2009; 458:219-54. PMID: 19374985.
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      91. Worthington AS, Hur GH, Meier JL, Cheng Q, Moore BS, Burkart M. Probing the compatibility of type II ketosynthase-carrier protein partners. Chembiochem. 2008 Sep 01; 9(13):2096-103. PMID: 18666307; PMCID: PMC2994244.
      92. Mercer AC, Meier JL, Hur GH, Smith AR, Burkart M. Antibiotic evaluation and in vivo analysis of alkynyl Coenzyme A antimetabolites in Escherichia coli. Bioorg Med Chem Lett. 2008 Nov 15; 18(22):5991-4. PMID: 18701278; PMCID: PMC3269959.
      93. Meier JL, Barrows-Yano T, Foley TL, Wike CL, Burkart M. The unusual macrocycle forming thioesterase of mycolactone. Mol Biosyst. 2008 Jun; 4(6):663-71. PMID: 18493665.
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      94. Meier JL, Mercer AC, Burkart M. Fluorescent profiling of modular biosynthetic enzymes by complementary metabolic and activity based probes. J Am Chem Soc. 2008 Apr 23; 130(16):5443-5. PMID: 18376827.
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      95. Ko KS, Najmabadi P, La Clair JJ, Burkart M. Affinity analyses on moldable optical polycarbonate. Chembiochem. 2008 Jan 25; 9(2):201-5. PMID: 18098256.
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      96. Kapur S, Worthington A, Tang Y, Cane DE, Burkart M, Khosla C. Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase. Bioorg Med Chem Lett. 2008 May 15; 18(10):3034-8. PMID: 18243693; PMCID: PMC2430738.
      97. Haushalter RW, Worthington AS, Hur GH, Burkart M. An orthogonal purification strategy for isolating crosslinked domains of modular synthases. Bioorg Med Chem Lett. 2008 May 15; 18(10):3039-42. PMID: 18249538; PMCID: PMC3269958.
      98. Mandel AL, Jones BD, La Clair JJ, Burkart M. A synthetic entry to pladienolide B and FD-895. Bioorg Med Chem Lett. 2007 Sep 15; 17(18):5159-64. PMID: 17681759; PMCID: PMC2652656.
      99. Mercer AC, Burkart M. The ubiquitous carrier protein--a window to metabolite biosynthesis. Nat Prod Rep. 2007 Aug; 24(4):750-73. PMID: 17653358.
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      100. Worthington AS, Burkart M. The old is new again: asparagine oxidation in calcium-dependent antibiotic biosynthesis. ACS Chem Biol. 2007 Mar 20; 2(3):152-4. PMID: 17373761.
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      101. Foley TL, Burkart M. Site-specific protein modification: advances and applications. Curr Opin Chem Biol. 2007 Feb; 11(1):12-9. PMID: 17189712.
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      102. Worthington AS, Rivera H, Torpey JW, Alexander MD, Burkart M. Mechanism-based protein cross-linking probes to investigate carrier protein-mediated biosynthesis. ACS Chem Biol. 2006 Dec 20; 1(11):687-91. PMID: 17184132.
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      103. Najmabadi P, La Clair JJ, Burkart M. A systems perspective to digital structures in molecular analysis. Org Biomol Chem. 2007 Jan 21; 5(2):214-22. PMID: 17205161.
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      104. Alexander MD, Fontaine SD, La Clair JJ, Dipasquale AG, Rheingold AL, Burkart M. Synthesis of the mycolactone core by ring-closing metathesis. Chem Commun (Camb). 2006 Nov 28; (44):4602-4. PMID: 17082856.
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      105. Meier JL, Mercer AC, Rivera H, Burkart M. Synthesis and evaluation of bioorthogonal pantetheine analogues for in vivo protein modification. J Am Chem Soc. 2006 Sep 20; 128(37):12174-84. PMID: 16967968.
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      106. La Clair JJ, Burkart M. Geometry in digital molecular arrays. Org Biomol Chem. 2006 Aug 21; 4(16):3052-5. PMID: 16886071.
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      107. Alexander MD, Burkart M, Leonard MS, Portonovo P, Liang B, Ding X, Joullié MM, Gulledge BM, Aggen JB, Chamberlin AR, Sandler J, Fenical W, Cui J, Gharpure SJ, Polosukhin A, Zhang HR, Evans PA, Richardson AD, Harper MK, Ireland CM, Vong BG, Brady TP, Theodorakis EA, La Clair JJ. A central strategy for converting natural products into fluorescent probes. Chembiochem. 2006 Mar; 7(3):409-16. PMID: 16432909.
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      108. Mercer AC, Burkart M. Chemical expansion of cofactor activity. Nat Chem Biol. 2006 Jan; 2(1):8-10. PMID: 16408081.
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      109. Worthington AS, Burkart M. One-pot chemo-enzymatic synthesis of reporter-modified proteins. Org Biomol Chem. 2006 Jan 07; 4(1):44-6. PMID: 16357994.
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      110. Shute TS, Matsushita M, Dickerson TJ, La Clair JJ, Janda KD, Burkart M. A site-specific bifunctional protein labeling system for affinity and fluorescent analysis. Bioconjug Chem. 2005 Nov-Dec; 16(6):1352-5. PMID: 16287229.
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      111. Clarke KM, Mercer AC, La Clair JJ, Burkart M. In vivo reporter labeling of proteins via metabolic delivery of coenzyme A analogues. J Am Chem Soc. 2005 Aug 17; 127(32):11234-5. PMID: 16089439.
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      112. Mercer AC, La Clair JJ, Burkart M. Fluorescent multiplex analysis of carrier protein post-translational modification. Chembiochem. 2005 Aug; 6(8):1335-7. PMID: 15997462.
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      113. Clarke KM, La Clair JJ, Burkart M. A three-component photoreversible tag for thiols. J Org Chem. 2005 Apr 29; 70(9):3709-11. PMID: 15845011.
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      114. Mercer AC, Burkart M. Enzyme-assisted antibiotic engineering--the Wright way. Chem Biol. 2005 Feb; 12(2):147-8. PMID: 15734642.
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      115. Nyffeler PT, Durón SG, Burkart M, Vincent SP, Wong CH. Selectfluor: mechanistic insight and applications. Angew Chem Int Ed Engl. 2004 Dec 27; 44(2):192-212. PMID: 15578736.
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      116. Mandel AL, La Clair JJ, Burkart M. Modular synthesis of pantetheine and phosphopantetheine. Org Lett. 2004 Dec 23; 6(26):4801-3. PMID: 15606070.
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      117. Merkel AB, Major LL, Errey JC, Burkart M, Field RA, Walsh CT, Naismith JH. The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme. J Biol Chem. 2004 Jul 30; 279(31):32684-91. PMID: 15159413.
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      118. La Clair JJ, Foley TL, Schegg TR, Regan CM, Burkart M. Manipulation of carrier proteins in antibiotic biosynthesis. Chem Biol. 2004 Feb; 11(2):195-201. PMID: 15123281.
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      119. La Clair JJ, Burkart M. Molecular screening on a compact disc. Org Biomol Chem. 2003 Sep 21; 1(18):3244-9. PMID: 14527159.
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      120. Burkart M. Metabolic engineering--a genetic toolbox for small molecule organic synthesis. Org Biomol Chem. 2003 Jan 07; 1(1):1-4. PMID: 12929378.
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      121. Kohli RM, Walsh CT, Burkart M. Biomimetic synthesis and optimization of cyclic peptide antibiotics. Nature. 2002 Aug 08; 418(6898):658-61. PMID: 12167866.
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      122. Marshall CG, Burkart M, Meray RK, Walsh CT. Carrier protein recognition in siderophore-producing nonribosomal peptide synthetases. Biochemistry. 2002 Jul 02; 41(26):8429-37. PMID: 12081492.
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      123. Merkel AB, Temple GK, Burkart M, Losey HC, Beis K, Walsh CT, Naismith JH. Purification, crystallization and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) from Amycolatopsis orientalis, the fourth enzyme in the dTDP-L-epivancosamine biosynthetic pathway. Acta Crystallogr D Biol Crystallogr. 2002 Jul; 58(Pt 7):1226-8. PMID: 12077451.
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      124. Thomas MG, Burkart M, Walsh CT. Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis. Chem Biol. 2002 Feb; 9(2):171-84. PMID: 11880032.
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      125. Luo L, Burkart M, Stachelhaus T, Walsh CT. Substrate recognition and selection by the initiation module PheATE of gramicidin S synthetase. J Am Chem Soc. 2001 Nov 14; 123(45):11208-18. PMID: 11697963.
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      126. Chen H, Thomas MG, O'Connor SE, Hubbard BK, Burkart M, Walsh CT. Aminoacyl-S-enzyme intermediates in beta-hydroxylations and alpha,beta-desaturations of amino acids in peptide antibiotics. Biochemistry. 2001 Oct 02; 40(39):11651-9. PMID: 11570865.
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      127. Marshall CG, Burkart M, Keating TA, Walsh CT. Heterocycle formation in vibriobactin biosynthesis: alternative substrate utilization and identification of a condensed intermediate. Biochemistry. 2001 Sep 04; 40(35):10655-63. PMID: 11524010.
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      128. Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart M. Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):11942-7. PMID: 11035791; PMCID: PMC17274.
      129. Burkart M, Izumi M, Chapman E, Lin CH, Wong CH. Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides. J Org Chem. 2000 Sep 08; 65(18):5565-74. PMID: 10970295.
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      130. Burkart M, Vincent SP, Düffels A, Murray BW, Ley SV, Wong CH. Chemo-enzymatic synthesis of fluorinated sugar nucleotide: useful mechanistic probes for glycosyltransferases. Bioorg Med Chem. 2000 Aug; 8(8):1937-46. PMID: 11003139.
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      131. Burkart M, Wong CH. A continuous assay for the spectrophotometric analysis of sulfotransferases using aryl sulfotransferase IV. Anal Biochem. 1999 Oct 01; 274(1):131-7. PMID: 10527506.
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      132. Burkart M, Toguchi A, Harshey RM. The chemotaxis system, but not chemotaxis, is essential for swarming motility in Escherichia coli. Proc Natl Acad Sci U S A. 1998 Mar 03; 95(5):2568-73. PMID: 9482927; PMCID: PMC19416.
      133. Murray BW, Wittmann V, Burkart M, Hung SC, Wong CH. Mechanism of human alpha-1,3-fucosyltransferase V: glycosidic cleavage occurs prior to nucleophilic attack. Biochemistry. 1997 Jan 28; 36(4):823-31. PMID: 9020780.
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