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    Michael Bouvet

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentSurgery
    Address9500 Gilman Drive #0987
    CA La Jolla 92093
    Phone858-822-6191
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      Collapse Overview 
      Collapse Overview
      Dr. Michael Bouvet specializes in surgical oncology and endocrine surgery. He performs surgeries for tumors of the pancreas, thyroid, parathyroid, adrenal, esophagus, and stomach, as well as for other conditions. He is also a specialist in endocrine surgery, including surgery for thyroid nodules and thyroid cancer, minimally invasive parathyroidectomy for primary hyperparathyroidism, and laparoscopic adrenal surgery. He is a member of the American Association of Endocrine Surgeons, the Society of Surgical Oncologists, the American Thyroid Association, and the American College of Surgeons. Dr. Bouvet is certified by the American Board of Surgery and has been selected as one of America’s Top Surgeons by the Consumers’ Research Council of America and one of San Diego's Top Doctors.

      Dr. Bouvet has extensive training and experience in cancer surgery. He completed advanced fellowship training in surgical oncology at the renowned MD Anderson Cancer Center at the University of Texas. Here at UC San Diego, Dr. Bouvet is a key surgeon and researcher at the Moores UC San Diego Cancer Center, where he serves as Co-Director of the Specialized Gastrointestinal Cancer Care Unit, Director of Endocrine Surgery, and Director of Surgical Services.

      Dr. Bouvet specializes in endocrine and pancreatic surgery. He routinely does surgery for thyroid nodules and thyroid cancer as well as minimally invasive surgery for hyperparathyroidism. He has performed many whipple procedures for pancreatic cancer.

      In his research at UC San Diego, Dr. Bouvet conducts major investigations on the growth and spread of pancreatic cancer and the treatment of pancreatic cancer and other tumors. He is an investigator on several major National Cancer Institute-funded studies on the treatment, understanding, and monitoring of pancreatic cancer. In his recent medical publications, he reported the causes and factors that influence its growth as well as new techniques for imaging pancreatic cancer. Make a donation for pancreatic cancer research.

      Research Overview
      My research interests include the development of multi-color fluorescent orthotopic mouse models of pancreatic cancer to study the tumor microenvironment. In addition, our lab has developed tumor specific fluorescent probes that can be used to improve laparoscopic staging and complete surgical resection of GI malignancies. We also have several projects related to surgical outcomes in patients with thyroid cancer.

      • Angiogenesis

      • Cancer

      • Cell Biology

      • Endocrinology

      • Minimally Invasive Techniques

      • Outcomes


      Current Project Titles

      • Color-Coded Imaging of Pancreatic Cancer Microenvironment for Drug Discovery

      • Fluorophore-Conjugated Antibodies for Imaging and Resection of GI Tumors

      • Tumor-stroma interactions in pancreatic cancer

      • Clinical outcomes in patients with thyroid cancer



      Resources

      Conditions and Treatments



      Collapse ORNG Applications 
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      Collapse In The News
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Tome Y, Yano S, Sugimoto N, Mii S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. Cover Image, Volume 118, Number 1, January 2017. J Cell Biochem. 2017 Jan; 118(1):i. PMID: 27870281.
        View in: PubMed
      2. Tome Y, Kimura H, Sugimoto N, Tsuchiya H, Kanaya F, Bouvet M, Hoffman RM. The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing a?ß3 integrin in chick embryo and nude mouse models. Oncotarget. 2016 Nov 22. PMID: 27894082.
        View in: PubMed
      3. Yano S, Takehara K, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. Tumor-targeting adenovirus OBP-401 inhibits primary and metastatic tumor growth of triple-negative breast cancer in orthotopic nude-mouse models. Oncotarget. 2016 Nov 11. PMID: 27863373.
        View in: PubMed
      4. Hiroshima Y, Lwin TM, Murakami T, Mawy AA, Kuniya T, Chishima T, Endo I, Clary BM, Hoffman RM, Bouvet M. Effective fluorescence-guided surgery of liver metastasis using a fluorescent anti-CEA antibody. J Surg Oncol. 2016 Oct 3. PMID: 27696448.
        View in: PubMed
      5. Hiroshima Y, Maawy A, Zhang Y, Zhang N, Murakami T, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy. Oncotarget. 2016 Sep 28. PMID: 27765934.
        View in: PubMed
      6. Zhang Y, Toneri M, Ma H, Yang Z, Bouvet M, Goto Y, Seki N, Hoffman RM. Real-Time GFP Intravital Imaging of the Differences in Cellular and Angiogenic Behavior of Subcutaneous and Orthotopic Nude-Mouse Models of Human PC-3 Prostate Cancer. J Cell Biochem. 2016 Nov; 117(11):2546-51. PMID: 27012365.
        View in: PubMed
      7. Hasegawa K, Suetsugu A, Nakamura M, Matsumoto T, Kunisada T, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. Color-coded Imaging Enables Fluorescence-guided Surgery to Resect the Tumor Along with the Tumor Microenvironment in a Syngeneic Mouse Model of EL-4 Lymphoma. Anticancer Res. 2016 Sep; 36(9):4443-8. PMID: 27630280.
        View in: PubMed
      8. Matsumoto T, Suetsugu A, Hasegawa K, Nakamura M, Shibata Y, Aoki H, Kunisada T, Tsurumi H, Shimizu M, Bouvet M, Hoffman RM. A Mouse Model of Fluorescent Protein-expressing Disseminated Peritoneal Lymphoma for Fluorescence-guided Surgery. Anticancer Res. 2016 Sep; 36(9):4483-7. PMID: 27630285.
        View in: PubMed
      9. Hoover M, Adamian Y, Brown M, Maawy A, Chang A, Lee J, Gharibi A, Katz MH, Fleming J, Hoffman RM, Bouvet M, Doebler R, Kelber JA. A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts. Oncotarget. 2016 Sep 1. PMID: 27602776.
        View in: PubMed
      10. Yamamoto M, Zhao M, Hiroshima Y, Zhang Y, Shurell E, Eilber FC, Bouvet M, Noda M, Hoffman RM. Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model. PLoS One. 2016; 11(8):e0160882. PMID: 27500926.
        View in: PubMed
      11. Yano S, Takehara K, Miwa S, Kishimoto H, Tazawa H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. In Vivo Isolation of a Highly-aggressive Variant of Triple-negative Human Breast Cancer MDA-MB-231 Using Serial Orthotopic Transplantation. Anticancer Res. 2016 Aug; 36(8):3817-20. PMID: 27466482.
        View in: PubMed
      12. Tome Y, Uehara F, Miwa S, Yano S, Mii S, Efimova EV, Bouvet M, Kimura H, Tsuchiya H, Kanaya F, Hoffman RM. Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein. Anticancer Res. 2016 Aug; 36(8):3821-6. PMID: 27466483.
        View in: PubMed
      13. Suetsugu A, Matsumoto T, Hasegawa K, Nakamura M, Kunisada T, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. Color-coded Live Imaging of Heterokaryon Formation and Nuclear Fusion of Hybridizing Cancer Cells. Anticancer Res. 2016 Aug; 36(8):3827-31. PMID: 27466484.
        View in: PubMed
      14. Tome Y, Yano S, Sugimoto N, Mii S, Uehara F, Miwa S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. Use of av Integrin Linked to Green Fluorescent Protein in Osteosarcoma Cells and Confocal Microscopy to Image Molecular Dynamics During Lung Metastasis in Nude Mice. Anticancer Res. 2016 Aug; 36(8):3811-6. PMID: 27466481.
        View in: PubMed
      15. Murakami T, Singh AS, Kiyuna T, Dry SM, Li Y, James AW, Igarashi K, Kawaguchi K, DeLong JC, Zhang Y, Hiroshima Y, Russell T, Eckardt MA, Yanagawa J, Federman N, Matsuyama R, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM. Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. Oncotarget. 2016 Jul 26; 7(30):47556-47564. PMID: 27286459.
        View in: PubMed
      16. Tome Y, Yano S, Sugimoto N, Mii S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. Use of av Integrin Linked to GFP to Image Molecular Dynamics in Trafficking Cancer-Cell Emboli. J Cell Biochem. 2017 Jan; 118(1):26-30. PMID: 27191371.
        View in: PubMed
      17. Kiyuna T, Murakami T, Tome Y, Kawaguchi K, Igarashi K, Zhang Y, Zhao M, Li Y, Bouvet M, Kanaya F, Singh A, Dry S, Eilber FC, Hoffman RM. High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model. Oncotarget. 2016 May 31; 7(22):33046-54. PMID: 27105519.
        View in: PubMed
      18. Yano S, Takehara K, Zhao M, Tan Y, Han Q, Li S, Bouvet M, Fujiwara T, Hoffman RM. Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging. Cell Cycle. 2016 Jul 2; 15(13):1715-23. PMID: 27152859.
        View in: PubMed
      19. Hasegawa K, Suetsugu A, Nakamura M, Matsumoto T, Aoki H, Kunisada T, Bouvet M, Shimizu M, Hoffman RM. Imaging Nuclear-Cytoplasmic Dynamics in Primary and Metastatic Colon Cancer in Nude Mice. Anticancer Res. 2016 May; 36(5):2113-7. PMID: 27127111.
        View in: PubMed
      20. Murakami T, Zhang Y, Wang X, Hiroshima Y, Kasashima H, Yashiro M, Hirakawa K, Miwa A, Kiyuna T, Matsuyama R, Tanaka K, Bouvet M, Endo I, Hoffman RM. Orthotopic Implantation of Intact Tumor Tissue Leads to Metastasis of OCUM-2MD3 Human Gastric Cancer in Nude Mice Visualized in Real Time by Intravital Fluorescence Imaging. Anticancer Res. 2016 May; 36(5):2125-30. PMID: 27127113.
        View in: PubMed
      21. Park JY, Lee JY, Zhang Y, Hoffman RM, Bouvet M. Targeting the insulin growth factor-1 receptor with fluorescent antibodies enables high resolution imaging of human pancreatic cancer in orthotopic mouse models. Oncotarget. 2016 Apr 5; 7(14):18262-8. PMID: 26919100.
        View in: PubMed
      22. Yano S, Takehara K, Kishimoto H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. Adenoviral targeting of malignant melanoma for fluorescence-guided surgery prevents recurrence in orthotopic nude-mouse models. Oncotarget. 2016 Apr 5; 7(14):18558-72. PMID: 26701857.
        View in: PubMed
      23. Fuchs HF, Broderick RC, Harnsberger CR, Divo FA, Coker AM, Jacobsen GR, Sandler BJ, Bouvet M, Horgan S. Intraoperative Endoscopic Botox Injection During Total Esophagectomy Prevents the Need for Pyloromyotomy or Dilatation. J Laparoendosc Adv Surg Tech A. 2016 Jun; 26(6):433-8. PMID: 27043862.
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      24. Murakami T, DeLong J, Eilber FC, Zhao M, Zhang Y, Zhang N, Singh A, Russell T, Deng S, Reynoso J, Quan C, Hiroshima Y, Matsuyama R, Chishima T, Tanaka K, Bouvet M, Chawla S, Endo I, Hoffman RM. Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model. Oncotarget. 2016 Mar 15; 7(11):12783-90. PMID: 26859573.
        View in: PubMed
      25. Yano S, Takehara K, Miwa S, Kishimoto H, Hiroshima Y, Murakami T, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. Improved Resection and Outcome of Colon-Cancer Liver Metastasis with Fluorescence-Guided Surgery Using In Situ GFP Labeling with a Telomerase-Dependent Adenovirus in an Orthotopic Mouse Model. PLoS One. 2016; 11(2):e0148760. PMID: 26849435.
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      26. Miwa S, De Magalhães N, Toneri M, Zhang Y, Cao W, Bouvet M, Tsuchiya H, Hoffman RM. Fluorescence-guided surgery of human prostate cancer experimental bone metastasis in nude mice using anti-CEA DyLight 650 for tumor illumination. J Orthop Res. 2016 Apr; 34(4):559-65. PMID: 26135883.
        View in: PubMed
      27. Orosco RK, Savariar EN, Weissbrod PA, Diaz-Perez JA, Bouvet M, Tsien RY, Nguyen QT. Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model. J Surg Oncol. 2016 Feb; 113(2):138-43. PMID: 26799257.
        View in: PubMed
      28. Park JY, Murakami T, Lee JY, Zhang Y, Hoffman RM, Bouvet M. Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models. PLoS One. 2016; 11(1):e0146504. PMID: 26731105.
        View in: PubMed
      29. Hoffman RM, Bouvet M. Imaging the microenvironment of pancreatic cancer patient-derived orthotopic xenografts (PDOX) growing in transgenic nude mice expressing GFP, RFP, or CFP. Cancer Lett. 2016 Sep 28; 380(1):349-55. PMID: 26742463.
        View in: PubMed
      30. Murakami T, Hiroshima Y, Zhao M, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model. Oncotarget. 2015 Dec 8; 6(39):41856-62. PMID: 26497690.
        View in: PubMed
      31. DeLong JC, Hoffman RM, Bouvet M. Current status and future perspectives of fluorescence-guided surgery for cancer. Expert Rev Anticancer Ther. 2016 Jan; 16(1):71-81. PMID: 26567611.
        View in: PubMed
      32. Suetsugu A, Momiyama M, Hiroshima Y, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. Color-Coded Imaging of Breast Cancer Metastatic Niche Formation in Nude Mice. J Cell Biochem. 2015 Dec; 116(12):2730-4. PMID: 25981355.
        View in: PubMed
      33. Yano S, Miwa S, Kishimoto H, Urata Y, Tazawa H, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. Eradication of osteosarcoma by fluorescence-guided surgery with tumor labeling by a killer-reporter adenovirus. J Orthop Res. 2016 May; 34(5):836-44. PMID: 26479501.
        View in: PubMed
      34. Suetsugu A, Hiroshima Y, Matsumoto T, Hasagawa K, Nakamura M, Shimizu M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. Recruitment of Cancer-Associated Fibroblasts and Blood Vessels by Orthotopic Liver Tumors Imaged in Red Fluorescent Protein (RFP) Transgenic Nude Mice. Anticancer Res. 2015 Nov; 35(11):5821-5. PMID: 26504003.
        View in: PubMed
      35. Murakami T, Hiroshima Y, Zhao M, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. Therapeutic efficacy of tumor-targeting Salmonella typhimurium A1-R on human colorectal cancer liver metastasis in orthotopic nude-mouse models. Oncotarget. 2015 Oct 13; 6(31):31368-77. PMID: 26375054.
        View in: PubMed
      36. Toneri M, Miwa S, Zhang Y, Hu C, Yano S, Matsumoto Y, Bouvet M, Nakanishi H, Hoffman RM, Zhao M. Tumor-targeting Salmonella typhimurium A1-R inhibits human prostate cancer experimental bone metastasis in mouse models. Oncotarget. 2015 Oct 13; 6(31):31335-43. PMID: 26431498.
        View in: PubMed
      37. Murakami T, Hiroshima Y, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM. Fluorescence-Guided Surgery of Liver Metastasis in Orthotopic Nude-Mouse Models. PLoS One. 2015; 10(10):e0138752. PMID: 26427050.
        View in: PubMed
      38. DeLong JC, Chakedis JM, Hosseini A, Kelly KJ, Horgan S, Bouvet M. Indocyanine green (ICG) fluorescence-guided laparoscopic adrenalectomy. J Surg Oncol. 2015 Nov; 112(6):650-3. PMID: 26420733.
        View in: PubMed
      39. Weiss A, Parina RP, Tang JA, Brumund KT, Chang DC, Bouvet M. Outcomes of thyroidectomy from a large California state database. Am J Surg. 2015 Dec; 210(6):1170-7. PMID: 26482517.
        View in: PubMed
      40. Yano S, Zhang Y, Miwa S, Kishimoto H, Urata Y, Bouvet M, Kagawa S, Fujiwara T, Hoffman RM. Precise navigation surgery of tumours in the lung in mouse models enabled by in situ fluorescence labelling with a killer-reporter adenovirus. BMJ Open Respir Res. 2015; 2(1):e000096. PMID: 26380093.
        View in: PubMed
      41. Chakedis JM, Maser C, Brumund KT, Bouvet M. Indocyanine green fluorescence-guided redo parathyroidectomy. BMJ Case Rep. 2015; 2015. PMID: 26336189.
        View in: PubMed
      42. Murakami T, Hiroshima Y, Zhang Y, Bouvet M, Chishima T, Tanaka K, Endo I, Hoffman RM. Improved disease-free survival and overall survival after fluorescence-guided surgery of liver metastasis in an orthotopic nude mouse model. J Surg Oncol. 2015 Aug; 112(2):119-24. PMID: 26266663.
        View in: PubMed
      43. Hiroshima Y, Zhao M, Zhang Y, Zhang N, Maawy A, Murakami T, Mii S, Uehara F, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. Tumor-Targeting Salmonella typhimurium A1-R Arrests a Chemo-Resistant Patient Soft-Tissue Sarcoma in Nude Mice. PLoS One. 2015; 10(8):e0134324. PMID: 26237416.
        View in: PubMed
      44. Hiroshima Y, Zhang Y, Zhao M, Zhang N, Murakami T, Maawy A, Mii S, Uehara F, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. Tumor-Targeting Salmonella typhimurium A1-R in Combination with Trastuzumab Eradicates HER-2-Positive Cervical Cancer Cells in Patient-Derived Mouse Models. PLoS One. 2015; 10(6):e0120358. PMID: 26047477.
        View in: PubMed
      45. Yano S, Miwa S, Kishimoto H, Uehara F, Tazawa H, Toneri M, Hiroshima Y, Yamamoto M, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM. Targeting tumors with a killer-reporter adenovirus for curative fluorescence-guided surgery of soft-tissue sarcoma. Oncotarget. 2015 May 30; 6(15):13133-48. PMID: 26033451.
        View in: PubMed
      46. Matsumoto Y, Miwa S, Zhang Y, Zhao M, Yano S, Uehara F, Yamamoto M, Hiroshima Y, Toneri M, Bouvet M, Matsubara H, Tsuchiya H, Hoffman RM. Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice. Oncotarget. 2015 May 10; 6(13):11369-77. PMID: 25957417.
        View in: PubMed
      47. Hoffman RM, Bouvet M. Nanoparticle albumin-bound-paclitaxel: a limited improvement under the current therapeutic paradigm of pancreatic cancer. Expert Opin Pharmacother. 2015 May; 16(7):943-7. PMID: 25887245.
        View in: PubMed
      48. Suetsugu A, Snyder CS, Moriwaki H, Saji S, Bouvet M, Hoffman RM. Imaging the Interaction of Pancreatic Cancer and Stellate Cells in the Tumor Microenvironment during Metastasis. Anticancer Res. 2015 May; 35(5):2545-51. PMID: 25964528.
        View in: PubMed
      49. Bouvet M, Hoffman RM. Toward Curative Fluorescence-Guided Surgery of Pancreatic Cancer. Hepatogastroenterology. 2015 May; 62(139):715-22. PMID: 26897960.
        View in: PubMed
      50. Yano S, Miwa S, Kishimoto H, Toneri M, Hiroshima Y, Yamamoto M, Bouvet M, Urata Y, Tazawa H, Kagawa S, Fujiwara T, Hoffman RM. Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus. Mol Ther. 2015 Jul; 23(7):1182-8. PMID: 25896244.
        View in: PubMed
      51. Hiroshima Y, Maawy A, Zhang Y, Guzman MG, Heim R, Makings L, Luiken GA, Kobayashi H, Tanaka K, Endo I, Hoffman RM, Bouvet M. Photoimmunotherapy Inhibits Tumor Recurrence After Surgical Resection on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model. Ann Surg Oncol. 2015 Dec; 22 Suppl 3:1469-74. PMID: 25893411.
        View in: PubMed
      52. Park JY, Hiroshima Y, Lee JY, Maawy AA, Hoffman RM, Bouvet M. MUC1 Selectively Targets Human Pancreatic Cancer in Orthotopic Nude Mouse Models. PLoS One. 2015; 10(3):e0122100. PMID: 25815753.
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      53. Maawy AA, Hiroshima Y, Zhang Y, Heim R, Makings L, Garcia-Guzman M, Luiken GA, Kobayashi H, Hoffman RM, Bouvet M. Near Infra-Red Photoimmunotherapy with Anti-CEA-IR700 Results in Extensive Tumor Lysis and a Significant Decrease in Tumor Burden in Orthotopic Mouse Models of Pancreatic Cancer. PLoS One. 2015; 10(3):e0121989. PMID: 25799218.
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      54. Yano S, Miwa S, Mii S, Hiroshima Y, Uehara F, Kishimoto H, Tazawa H, Zhao M, Bouvet M, Fujiwara T, Hoffman RM. Cancer cells mimic in vivo spatial-temporal cell-cycle phase distribution and chemosensitivity in 3-dimensional Gelfoam® histoculture but not 2-dimensional culture as visualized with real-time FUCCI imaging. Cell Cycle. 2015 Mar 19; 14(6):808-19. PMID: 25564963.
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      55. Zhang L, Wu C, Bouvet M, Yano S, Hoffman RM. Traditional Chinese medicine herbal mixture LQ arrests FUCCI-expressing HeLa cells in G0/G1 phase in 2D plastic, 2.5D Matrigel®, and 3D Gelfoam® culture visualized with FUCCI imaging. Oncotarget. 2015 Mar 10; 6(7):5292-8. PMID: 25779660.
        View in: PubMed
      56. Hiroshima Y, Maawy A, Zhang Y, Murakami T, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Endo I, Hoffman RM, Bouvet M. Fluorescence-guided surgery, but not bright-light surgery, prevents local recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) model resistant to neoadjuvant chemotherapy (NAC). Pancreatology. 2015 May-Jun; 15(3):295-301. PMID: 25800176.
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      57. Kanack MD, Maawy AA, Oh DK, Bouvet M. Undescended parathyroid adenoma. BMJ Case Rep. 2015; 2015. PMID: 25737222.
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      58. Bouvet M, Hoffman RM. Fluorescence-Guided Surgery: It Is the Cure That Matters: In Reply to Giorgakis and colleagues. J Am Coll Surg. 2015 Mar; 220(3):377-9. PMID: 25700908.
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      59. Uehara F, Hiroshima Y, Miwa S, Tome Y, Yano S, Yamamoto M, Matsumoto Y, Maehara H, Tanaka K, Bouvet M, Kanaya F, Hoffman RM. Fluorescence-guided surgery of retroperitoneal-implanted human fibrosarcoma in nude mice delays or eliminates tumor recurrence and increases survival compared to bright-light surgery. PLoS One. 2015; 10(2):e0116865. PMID: 25710463.
        View in: PubMed
      60. Maawy AA, Hiroshima Y, Zhang Y, Garcia-Guzman M, Luiken GA, Kobayashi H, Hoffman RM, Bouvet M. Photoimmunotherapy lowers recurrence after pancreatic cancer surgery in orthotopic nude mouse models. J Surg Res. 2015 Jul; 197(1):5-11. PMID: 25799527.
        View in: PubMed
      61. Hiroshima Y, Zhang Y, Zhang N, Maawy A, Mii S, Yamamoto M, Uehara F, Miwa S, Yano S, Murakami T, Momiyama M, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Murata T, Endo I, Hoffman RM. Establishment of a Patient-Derived Orthotopic Xenograft (PDOX) Model of HER-2-Positive Cervical Cancer Expressing the Clinical Metastatic Pattern. PLoS One. 2015; 10(2):e0117417. PMID: 25689852.
        View in: PubMed
      62. Miwa S, Yano S, Kimura H, Yamamoto M, Toneri M, Matsumoto Y, Uehara F, Hiroshima Y, Murakami T, Hayashi K, Yamamoto N, Bouvet M, Fujiwara T, Tsuchiya H, Hoffman RM. Cell-cycle fate-monitoring distinguishes individual chemosensitive and chemoresistant cancer cells in drug-treated heterogeneous populations demonstrated by real-time FUCCI imaging. Cell Cycle. 2015 Feb 16; 14(4):621-9. PMID: 25551170.
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      63. Hiroshima Y, Zhang Y, Zhang N, Uehara F, Maawy A, Murakami T, Mii S, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM. Patient-derived Orthotopic Xenograft (PDOX) Nude Mouse Model of Soft-tissue Sarcoma More Closely Mimics the Patient Behavior in Contrast to the Subcutaneous Ectopic Model. Anticancer Res. 2015 Feb; 35(2):697-701. PMID: 25667448.
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      64. Bouvet M, Hoffman RM. Tumor imaging technologies in mouse models. Methods Mol Biol. 2015; 1267:321-48. PMID: 25636477.
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      65. Orosco RK, Hussain T, Brumund KT, Oh DK, Chang DC, Bouvet M. Analysis of age and disease status as predictors of thyroid cancer-specific mortality using the surveillance, epidemiology, and end results database. Thyroid. 2015 Jan; 25(1):125-32. PMID: 25369076.
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      66. Miwa S, Zhang Y, Baek KE, Uehara F, Yano S, Yamamoto M, Hiroshima Y, Matsumoto Y, Kimura H, Hayashi K, Yamamoto N, Bouvet M, Tsuchiya H, Hoffman RM, Zhao M. Inhibition of spontaneous and experimental lung metastasis of soft-tissue sarcoma by tumor-targeting Salmonella typhimurium A1-R. Oncotarget. 2014 Dec 30; 5(24):12849-61. PMID: 25528763.
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      67. Hiroshima Y, Zhang Y, Murakami T, Maawy A, Miwa S, Yamamoto M, Yano S, Sato S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Zhao M, Hoffman RM. Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models. Oncotarget. 2014 Dec 15; 5(23):12346-57. PMID: 25402324.
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      68. Yano S, Zhang Y, Zhao M, Hiroshima Y, Miwa S, Uehara F, Kishimoto H, Tazawa H, Bouvet M, Fujiwara T, Hoffman RM. Tumor-targeting Salmonella typhimurium A1-R decoys quiescent cancer cells to cycle as visualized by FUCCI imaging and become sensitive to chemotherapy. Cell Cycle. 2014 Dec 15; 13(24):3958-63. PMID: 25483077.
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      69. Hiroshima Y, Maawy A, Zhang Y, Murakami T, Momiyama M, Mori R, Matsuyama R, Katz MH, Fleming JB, Chishima T, Tanaka K, Ichikawa Y, Endo I, Hoffman RM, Bouvet M. Metastatic Recurrence in a Pancreatic Cancer Patient Derived Orthotopic Xenograft (PDOX) Nude Mouse Model Is Inhibited by Neoadjuvant Chemotherapy in Combination with Fluorescence-Guided Surgery with an Anti-CA 19-9-Conjugated Fluorophore. PLoS One. 2014; 9(12):e114310. PMID: 25463150.
        View in: PubMed
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      77. Uehara F, Tome Y, Miwa S, Hiroshima Y, Yano S, Yamamoto M, Mii S, Maehara H, Bouvet M, Kanaya F, Hoffman RM. Osteosarcoma cells enhance angiogenesis visualized by color-coded imaging in the in vivo gelfoam® assay. J Cell Biochem. 2014 Sep; 115(9):1490-4. PMID: 24590470.
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      81. Tome Y, Uehara F, Mii S, Yano S, Zhang L, Sugimoto N, Maehara H, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. 3-Dimensional Tissue Is Formed From Cancer Cells In Vitro on Gelfoam(®) , But Not on Matrigel(TM.). J Cell Biochem. 2014 Aug; 115(8):1362-7. PMID: 24497277.
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      84. Maawy AA, Hiroshima Y, Zhang Y, Luiken GA, Hoffman RM, Bouvet M. Polyethylene Glycol (PEG) Linked to Near Infrared (NIR) Dyes Conjugated to Chimeric Anti-Carcinoembryonic Antigen (CEA) Antibody Enhances Imaging of Liver Metastases in a Nude-Mouse Model of Human Colon Cancer. PLoS One. 2014; 9(5):e97965. PMID: 24859320.
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      91. Bouvet M. Is there a need for yet another staging system for differentiated thyroid cancer? Endocrine. 2014 Jun; 46(2):179-80. PMID: 24532102.
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      94. Yano S, Miwa S, Mii S, Hiroshima Y, Uehara F, Yamamoto M, Kishimoto H, Tazawa H, Bouvet M, Fujiwara T, Hoffman RM. Invading cancer cells are predominantly in G 0/G 1 resulting in chemoresistance demonstrated by real-time FUCCI imaging. Cell Cycle. 2014 Mar 15; 13(6):953-60. PMID: 24552821.
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      95. Coker AM, Barajas-Gamboa JS, Cheverie J, Jacobsen GR, Sandler BJ, Talamini MA, Bouvet M, Horgan S. Outcomes of robotic-assisted transhiatal esophagectomy for esophageal cancer after neoadjuvant chemoradiation. J Laparoendosc Adv Surg Tech A. 2014 Feb; 24(2):89-94. PMID: 24401141.
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      107. Uehara F, Tome Y, Reynoso J, Mii S, Yano S, Miwa S, Bouvet M, Maehara H, Kanaya F, Moossa AR, Hoffman RM. Color-coded imaging of spontaneous vessel anastomosis in vivo. Anticancer Res. 2013 Aug; 33(8):3041-5. PMID: 23898058.
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      152. Suetsugu A, Osawa Y, Nagaki M, Saji S, Moriwaki H, Bouvet M, Hoffman RM. Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer. J Cell Biochem. 2011 Mar; 112(3):949-53. PMID: 21328469.
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      153. Suetsugu A, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM. Simultaneous color-coded imaging to distinguish cancer "stem-like" and non-stem cells in the same tumor. J Cell Biochem. 2010 Nov 1; 111(4):1035-41. PMID: 20672309.
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      154. Tran Cao HS, Kaushal S, Snyder CS, Ongkeko WM, Hoffman RM, Bouvet M. Real-time imaging of tumor progression in a fluorescent orthotopic mouse model of thyroid cancer. Anticancer Res. 2010 Nov; 30(11):4415-22. PMID: 21115887.
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      155. Erten A, Hall D, Hoh C, Tran Cao HS, Kaushal S, Esener S, Hoffman RM, Bouvet M, Chen J, Kesari S, Makale M. Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging. J Biomed Opt. 2010 Nov-Dec; 15(6):066012. PMID: 21198186.
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      156. Gros SJ, Dohrmann T, Rawnaq T, Kurschat N, Bouvet M, Wessels J, Hoffmann RM, Izbicki JR, Kaifi JT. Orthotopic fluorescent peritoneal carcinomatosis model of esophageal cancer. Anticancer Res. 2010 Oct; 30(10):3933-8. PMID: 21036705.
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      157. Kimura H, Lee C, Hayashi K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Bouvet M, Hoffman RM. UV light killing efficacy of fluorescent protein-expressing cancer cells in vitro and in vivo. J Cell Biochem. 2010 Aug 15; 110(6):1439-46. PMID: 20506255.
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      158. Grzesiak JJ, Vargas F, Bouvet M. Divalent cations modulate alpha2beta1 integrin-mediated malignancy in a novel 3-dimensional in vitro model of pancreatic cancer. Pancreas. 2010 Aug; 39(6):904-12. PMID: 20182393.
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      159. Ganesan K, Achmad E, Sirlin CB, Bouvet M, Datnow B, Weidner N, Peterson MR. Amphicrine carcinoma of the liver. Ann Diagn Pathol. 2011 Oct; 15(5):355-7. PMID: 20952282.
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      160. Tran Cao HS, Bouvet M, Kaushal S, Keleman A, Romney E, Kim G, Fruehauf J, Imagawa DK, Hoffman RM, Katz MH. Metronomic gemcitabine in combination with sunitinib inhibits multisite metastasis and increases survival in an orthotopic model of pancreatic cancer. Mol Cancer Ther. 2010 Jul; 9(7):2068-78. PMID: 20606044.
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      161. Erten A, Wrasidlo W, Scadeng M, Esener S, Hoffman RM, Bouvet M, Makale M. Magnetic resonance and fluorescence imaging of doxorubicin-loaded nanoparticles using a novel in vivo model. Nanomedicine. 2010 Dec; 6(6):797-807. PMID: 20599526.
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      162. Ma H, Li X, Yang Z, Okuno S, Kawaguchi T, Yagi S, Bouvet M, Hoffman RM. High antimetastatic efficacy of MEN4901/T-0128, a novel camptothecin carboxymethyldextran conjugate. J Surg Res. 2011 Dec; 171(2):684-90. PMID: 20851421.
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      163. Tran Cao HS, Kaushal S, Lee C, Snyder CS, Thompson KJ, Horgan S, Talamini MA, Hoffman RM, Bouvet M. Fluorescence laparoscopy imaging of pancreatic tumor progression in an orthotopic mouse model. Surg Endosc. 2011 Jan; 25(1):48-54. PMID: 20533064.
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      164. Hu CM, Kaushal S, Tran Cao HS, Aryal S, Sartor M, Esener S, Bouvet M, Zhang L. Half-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen presenting pancreatic cancer cells. Mol Pharm. 2010 Jun 7; 7(3):914-20. PMID: 20394436.
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      165. Wang Y, Kelber JA, Tran Cao HS, Cantin GT, Lin R, Wang W, Kaushal S, Bristow JM, Edgington TS, Hoffman RM, Bouvet M, Yates JR, Klemke RL. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10920-5. PMID: 20534451.
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      166. Zhou J, Hu L, Yu Z, Zheng J, Yang D, Bouvet M, Hoffman RM. Marker expression in circulating cancer cells of pancreatic cancer patients. J Surg Res. 2011 Dec; 171(2):631-6. PMID: 20869080.
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      167. Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, Klemke RL, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4299-304. PMID: 20154271.
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      168. Kimura H, Hayashi K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Kishimoto H, Bouvet M, Hoffman RM. Real-time imaging of single cancer-cell dynamics of lung metastasis. J Cell Biochem. 2010 Jan 1; 109(1):58-64. PMID: 19911396.
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      169. Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS, Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF, Cheresh DA. RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. Proc Natl Acad Sci U S A. 2010 Feb 2; 107(5):2189-94. PMID: 20080647.
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      170. Bouvet M, Hoffman RM. Clinically-relevent orthotopic metastatic models of pancreatic cancer imageable with fluorescent genetic reporters. Minerva Chir. 2009 Oct; 64(5):521-39. PMID: 19859041.
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      171. McElroy MK, Kaushal S, Tran Cao HS, Moossa AR, Talamini MA, Hoffman RM, Bouvet M. Upregulation of thrombospondin-1 and angiogenesis in an aggressive human pancreatic cancer cell line selected for high metastasis. Mol Cancer Ther. 2009 Jul; 8(7):1779-86. PMID: 19584238.
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      172. Nagakura C, Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Bouvet M, Hoffman RM. Efficacy of a genetically-modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice. Anticancer Res. 2009 Jun; 29(6):1873-8. PMID: 19528442.
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      173. Tran Cao HS, Reynoso J, Yang M, Kimura H, Kaushal S, Snyder CS, Hoffman RM, Bouvet M. Development of the transgenic cyan fluorescent protein (CFP)-expressing nude mouse for "Technicolor" cancer imaging. J Cell Biochem. 2009 May 15; 107(2):328-34. PMID: 19306297.
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      174. Snyder CS, Kaushal S, Kono Y, Tran Cao HS, Hoffman RM, Bouvet M. Complementarity of ultrasound and fluorescence imaging in an orthotopic mouse model of pancreatic cancer. BMC Cancer. 2009; 9:106. PMID: 19351417.
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      175. Yam C, Zhao M, Hayashi K, Ma H, Kishimoto H, McElroy M, Bouvet M, Hoffman RM. Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer. J Surg Res. 2010 Dec; 164(2):248-55. PMID: 19766244.
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      176. Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Kishimoto H, Bouvet M, Hoffman RM. Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium. Cell Cycle. 2009 Mar 15; 8(6):870-5. PMID: 19221501.
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      177. Tran Cao HS, Kimura H, Kaushal S, Snyder CS, Reynoso J, Hoffman RM, Bouvet M. The cyan fluorescent protein (CFP) transgenic mouse as a model for imaging pancreatic exocrine cells. JOP. 2009; 10(2):152-6. PMID: 19287108.
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      178. Makale M, McElroy M, O'Brien P, Hoffman RM, Guo S, Bouvet M, Barnes L, Ingulli E, Cheresh D. Extended-working-distance multiphoton micromanipulation microscope for deep-penetration imaging in live mice and tissue. J Biomed Opt. 2009 Mar-Apr; 14(2):024032. PMID: 19405761.
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      179. Yang M, Reynoso J, Bouvet M, Hoffman RM. A transgenic red fluorescent protein-expressing nude mouse for color-coded imaging of the tumor microenvironment. J Cell Biochem. 2009 Feb 1; 106(2):279-84. PMID: 19097136.
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      180. Zhou J, Yu Z, Zhao S, Hu L, Zheng J, Yang D, Bouvet M, Hoffman RM. Lentivirus-based DsRed-2-transfected pancreatic cancer cells for deep in vivo imaging of metastatic disease. J Surg Res. 2009 Nov; 157(1):63-70. PMID: 19589544.
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      181. McElroy M, Kaushal S, Bouvet M, Hoffman RM. Color-coded imaging of splenocyte-pancreatic cancer cell interactions in the tumor microenvironment. Cell Cycle. 2008 Sep 15; 7(18):2916-21. PMID: 18787410.
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      182. Grzesiak JJ, Bouvet M. Divalent cations modulate the integrin-mediated malignant phenotype in pancreatic cancer cells. Cancer Sci. 2008 Aug; 99(8):1553-63. PMID: 18754866.
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      183. Kaushal S, McElroy MK, Luiken GA, Talamini MA, Moossa AR, Hoffman RM, Bouvet M. Fluorophore-conjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer. J Gastrointest Surg. 2008 Nov; 12(11):1938-50. PMID: 18665430.
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      184. McElroy M, Kaushal S, Luiken GA, Talamini MA, Moossa AR, Hoffman RM, Bouvet M. Imaging of primary and metastatic pancreatic cancer using a fluorophore-conjugated anti-CA19-9 antibody for surgical navigation. World J Surg. 2008 Jun; 32(6):1057-66. PMID: 18264829.
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      185. Chae AW, Perricone A, Brumund KT, Bouvet M. Outpatient video-assisted thoracoscopic surgery (VATS) for ectopic mediastinal parathyroid adenoma: a case report and review of the literature. J Laparoendosc Adv Surg Tech A. 2008 Jun; 18(3):383-90. PMID: 18503371.
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      186. Grzesiak JJ, Bouvet M. Activation of the alpha2beta1 integrin-mediated malignant phenotype on type I collagen in pancreatic cancer cells by shifts in the concentrations of extracellular Mg2+ and Ca2+. Int J Cancer. 2008 May 15; 122(10):2199-209. PMID: 18224679.
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      187. McElroy M, Hayashi K, Garmy-Susini B, Kaushal S, Varner JA, Moossa AR, Hoffman RM, Bouvet M. Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo. J Surg Res. 2009 Jan; 151(1):68-73. PMID: 18599080.
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      188. Yamauchi K, Yang M, Hayashi K, Jiang P, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM. Induction of cancer metastasis by cyclophosphamide pretreatment of host mice: an opposite effect of chemotherapy. Cancer Res. 2008 Jan 15; 68(2):516-20. PMID: 18199547.
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      189. McElroy M, Bouvet M, Hoffman RM. Chapter 2. Color-coded fluorescent mouse models of cancer cell interactions with blood vessels and lymphatics. Methods Enzymol. 2008; 445:27-52. PMID: 19022054.
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      190. Grzesiak JJ, Ho JC, Moossa AR, Bouvet M. The integrin-extracellular matrix axis in pancreatic cancer. Pancreas. 2007 Nov; 35(4):293-301. PMID: 18090233.
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      191. Hayashi K, Jiang P, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM. Real-time imaging of tumor-cell shedding and trafficking in lymphatic channels. Cancer Res. 2007 Sep 1; 67(17):8223-8. PMID: 17804736.
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      192. Yamauchi K, Yang M, Hayashi K, Jiang P, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM. Imaging of nucleolar dynamics during the cell cycle of cancer cells in live mice. Cell Cycle. 2007 Nov 1; 6(21):2706-8. PMID: 17912040.
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      193. Lee JK, Obrzut SL, Yi ES, Deftos LJ, Bouvet M. Incidental finding of metastatic papillary thyroid carcinoma in a patient with primary hyperparathyroidism. Endocr Pract. 2007 Jul-Aug; 13(4):380-3. PMID: 17669714.
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      194. Grzesiak JJ, Smith KC, Burton DW, Deftos LJ, Bouvet M. Integrin-mediated laminin-1 adhesion upregulates CXCR4 and IL-8 expression in pancreatic cancer cells. Surgery. 2007 Jun; 141(6):804-14. PMID: 17560257.
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      195. Hayashi K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Amoh Y, Hoffman RM, Bouvet M. Dual-color imaging of angiogenesis and its inhibition in bone and soft tissue sarcoma. J Surg Res. 2007 Jun 15; 140(2):165-70. PMID: 17418866.
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      196. Ji Y, Hayashi K, Amoh Y, Tsuji K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Bouvet M, Hoffman RM. The camptothecin derivative CPT-11 inhibits angiogenesis in a dual-color imageable orthotopic metastatic nude mouse model of human colon cancer. Anticancer Res. 2007 Mar-Apr; 27(2):713-8. PMID: 17465193.
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      197. Grzesiak JJ, Bouvet M. Determination of the ligand-binding specificities of the alpha2beta1 and alpha1beta1 integrins in a novel 3-dimensional in vitro model of pancreatic cancer. Pancreas. 2007 Mar; 34(2):220-8. PMID: 17312461.
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      198. Amoh Y, Li L, Katsuoka K, Bouvet M, Hoffman RM. GFP-expressing vascularization of Gelfoam as a rapid in vivo assay of angiogenesis stimulators and inhibitors. Biotechniques. 2007 Mar; 42(3):294, 296, 298. PMID: 17390535.
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      199. Bouvet M, Tsuji K, Yang M, Jiang P, Moossa AR, Hoffman RM. In vivo color-coded imaging of the interaction of colon cancer cells and splenocytes in the formation of liver metastases. Cancer Res. 2006 Dec 1; 66(23):11293-7. PMID: 17145875.
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      200. Amoh Y, Bouvet M, Li L, Tsuji K, Moossa AR, Katsuoka K, Hoffman RM. Visualization of nascent tumor angiogenesis in lung and liver metastasis by differential dual-color fluorescence imaging in nestin-linked-GFP mice. Clin Exp Metastasis. 2006; 23(7-8):315-22. PMID: 17136576.
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      201. Newman EM, Bouvet M, Borgehi S, Herold DA, Deftos LJ. Causes of hypercalcemia in a population of military veterans in the United States. Endocr Pract. 2006 Sep-Oct; 12(5):535-41. PMID: 17002928.
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      202. Amoh Y, Nagakura C, Maitra A, Moossa AR, Katsuoka K, Hoffman RM, Bouvet M. Dual-color imaging of nascent angiogenesis and its inhibition in liver metastases of pancreatic cancer. Anticancer Res. 2006 Sep-Oct; 26(5A):3237-42. PMID: 17094435.
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      203. Jiang P, Yamauchi K, Yang M, Tsuji K, Xu M, Maitra A, Bouvet M, Hoffman RM. Tumor cells genetically labeled with GFP in the nucleus and RFP in the cytoplasm for imaging cellular dynamics. Cell Cycle. 2006 Jun; 5(11):1198-201. PMID: 16760659.
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      204. Yamauchi K, Yang M, Jiang P, Xu M, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM. Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res. 2006 Apr 15; 66(8):4208-14. PMID: 16618743.
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      205. Tsuji K, Yang M, Jiang P, Maitra A, Kaushal S, Yamauchi K, Katz MH, Moossa AR, Hoffman RM, Bouvet M. Common bile duct injection as a novel method for establishing red fluorescent protein (RFP)-expressing human pancreatic cancer in nude mice. JOP. 2006; 7(2):193-9. PMID: 16525203.
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      206. Grzesiak JJ, Burton DW, Deftos LJ, Bouvet M. Identification of DU 145 prostate cancer cell proteins that bind to the carboxy-terminal peptide of human PTHrP in vitro. Peptides. 2006 Jul; 27(7):1898-901. PMID: 16513210.
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      207. Amoh Y, Li L, Tsuji K, Moossa AR, Katsuoka K, Hoffman RM, Bouvet M. Dual-color imaging of nascent blood vessels vascularizing pancreatic cancer in an orthotopic model demonstrates antiangiogenesis efficacy of gemcitabine. J Surg Res. 2006 May 15; 132(2):164-9. PMID: 16500746.
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      208. Tsuji K, Yamauchi K, Yang M, Jiang P, Bouvet M, Endo H, Kanai Y, Yamashita K, Moossa AR, Hoffman RM. Dual-color imaging of nuclear-cytoplasmic dynamics, viability, and proliferation of cancer cells in the portal vein area. Cancer Res. 2006 Jan 1; 66(1):303-6. PMID: 16397243.
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      209. Bouvet M, Spernyak J, Katz MH, Mazurchuk RV, Takimoto S, Bernacki R, Rustum YM, Moossa AR, Hoffman RM. High correlation of whole-body red fluorescent protein imaging and magnetic resonance imaging on an orthotopic model of pancreatic cancer. Cancer Res. 2005 Nov 1; 65(21):9829-33. PMID: 16267005.
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      210. Katz MH, Savides TJ, Moossa AR, Bouvet M. An evidence-based approach to the diagnosis and staging of pancreatic cancer. Pancreatology. 2005; 5(6):576-90. PMID: 16110256.
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      211. Amoh Y, Yang M, Li L, Reynoso J, Bouvet M, Moossa AR, Katsuoka K, Hoffman RM. Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis. Cancer Res. 2005 Jun 15; 65(12):5352-7. PMID: 15958583.
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      212. Tsuboi K, Grzesiak JJ, Bouvet M, Hashimoto M, Masliah E, Shults CW. Alpha-synuclein overexpression in oligodendrocytic cells results in impaired adhesion to fibronectin and cell death. Mol Cell Neurosci. 2005 Jun; 29(2):259-68. PMID: 15911350.
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      213. Yamauchi K, Yang M, Jiang P, Yamamoto N, Xu M, Amoh Y, Tsuji K, Bouvet M, Tsuchiya H, Tomita K, Moossa AR, Hoffman RM. Real-time in vivo dual-color imaging of intracapillary cancer cell and nucleus deformation and migration. Cancer Res. 2005 May 15; 65(10):4246-52. PMID: 15899816.
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      214. Grzesiak JJ, Smith KC, Chalberg C, Truong C, Burton DW, Deftos LJ, Bouvet M. Heat shock protein-70 expressed on the surface of cancer cells binds parathyroid hormone-related protein in vitro. Endocrinology. 2005 Aug; 146(8):3567-76. PMID: 15878959.
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      215. Grzesiak JJ, Smith KC, Burton DW, Deftos LJ, Bouvet M. GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells. Int J Cancer. 2005 Apr 20; 114(4):522-30. PMID: 15609321.
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      216. Grzesiak JJ, Smith KC, Chalberg C, Burton DW, Deftos LJ, Bouvet M. Type I collagen and divalent cation shifts disrupt cell-cell adhesion, increase migration, and decrease PTHrP, IL-6, and IL-8 expression in pancreatic cancer cells. Int J Gastrointest Cancer. 2005; 36(3):131-46. PMID: 16720909.
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      217. Grzesiak JJ, Clopton P, Chalberg C, Smith K, Burton DW, Silletti S, Moossa AR, Deftos LJ, Bouvet M. The extracellular matrix differentially regulates the expression of PTHrP and the PTH/PTHrP receptor in FG pancreatic cancer cells. Pancreas. 2004 Aug; 29(2):85-92. PMID: 15257098.
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      218. Katz MH, Bouvet M, Al-Refaie W, Gilpin EA, Moossa AR. Non-pancreatic periampullary adenocarcinomas: an explanation for favorable prognosis. Hepatogastroenterology. 2004 May-Jun; 51(57):842-6. PMID: 15143931.
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      219. Katz MH, Bouvet M, Takimoto S, Spivack D, Moossa AR, Hoffman RM. Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer. Cancer Res. 2004 Mar 1; 64(5):1828-33. PMID: 14996746.
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      220. Alrefaie W, Katz MH, Easter DW, Yi ES, Weidner N, Savides TJ, Moossa AR, Bouvet M. Simultaneous serous cystadenoma of the pancreas and mucinous cystadenoma of the appendix. JOP. 2004 Mar; 5(2):97-100. PMID: 15007191.
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      221. Takabe K, Holman PR, Herbst KD, Glass CA, Bouvet M. Successful perioperative management of factor X deficiency associated with primary amyloidosis. J Gastrointest Surg. 2004 Mar-Apr; 8(3):358-62. PMID: 15019934.
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      222. Katz MH, Takimoto S, Spivack D, Moossa AR, Hoffman RM, Bouvet M. An imageable highly metastatic orthotopic red fluorescent protein model of pancreatic cancer. Clin Exp Metastasis. 2004; 21(1):7-12. PMID: 15065597.
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      223. Zhou W, Katz MH, Deftos LJ, Snyder CS, Baird S, Bouvet M. Metachronous double parathyroid adenomas involving two different cell types: chief cell and oxyphil cell. Endocr Pract. 2003 Nov-Dec; 9(6):522-5. PMID: 14715480.
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      224. Katz MH, Bouvet M, Takimoto S, Spivack D, Moossa AR, Hoffman RM. Selective antimetastatic activity of cytosine analog CS-682 in a red fluorescent protein orthotopic model of pancreatic cancer. Cancer Res. 2003 Sep 1; 63(17):5521-5. PMID: 14500389.
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      225. Katz MH, Spivack DE, Takimoto S, Fang B, Burton DW, Moossa AR, Hoffman RM, Bouvet M. Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter. Ann Surg Oncol. 2003 Aug; 10(7):762-72. PMID: 12900367.
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      226. Katz MH, Takimoto S, Spivack D, Moossa AR, Hoffman RM, Bouvet M. A novel red fluorescent protein orthotopic pancreatic cancer model for the preclinical evaluation of chemotherapeutics. J Surg Res. 2003 Jul; 113(1):151-60. PMID: 12943825.
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      227. Overstreet K, Wixom C, Shabaik A, Bouvet M, Herndier B. Adenomatoid tumor of the pancreas: a case report with comparison of histology and aspiration cytology. Mod Pathol. 2003 Jun; 16(6):613-7. PMID: 12808068.
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      228. Sun FX, Tohgo A, Bouvet M, Yagi S, Nassirpour R, Moossa AR, Hoffman RM. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res. 2003 Jan 1; 63(1):80-5. PMID: 12517781.
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      229. Katz MH, Bouvet M. Novel gene therapy approaches to pancreatic cancer. Int J Gastrointest Cancer. 2003; 33(1):89-97. PMID: 12909741.
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      230. Du E, Overstreet K, Zhou W, Baird G, Baird S, Bouvet M, Haghighi P. Fine needle aspiration of splenic extramedullary hematopoiesis presenting as a solitary mass. A case report. Acta Cytol. 2002 Nov-Dec; 46(6):1138-42. PMID: 12462096.
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      231. Parhizkar N, Jones VE, McClay EF, Yi ES, Bouvet M. Metastatic melanoma in a patient with Clouston syndrome successfully treated with isolated hyperthermic limb perfusion. J Cutan Med Surg. 2003 Jan-Feb; 7(1):43-6. PMID: 12362262.
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      232. Shen J, Wallace AM, Bouvet M. The role of sentinel lymph node biopsy for melanoma. Semin Oncol. 2002 Aug; 29(4):341-52. PMID: 12170437.
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      233. Pirocanac EC, Nassirpour R, Yang M, Wang J, Nardin SR, Gu J, Fang B, Moossa AR, Hoffman RM, Bouvet M. Bax-induction gene therapy of pancreatic cancer. J Surg Res. 2002 Aug; 106(2):346-51. PMID: 12175991.
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      234. Bouvet M, Nardin SR, Burton DW, Lee NC, Yang M, Wang X, Baranov E, Behling C, Moossa AR, Hoffman RM, Deftos LJ. Parathyroid hormone-related protein as a novel tumor marker in pancreatic adenocarcinoma. Pancreas. 2002 Apr; 24(3):284-90. PMID: 11893937.
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      235. Yang M, Baranov E, Wang JW, Jiang P, Wang X, Sun FX, Bouvet M, Moossa AR, Penman S, Hoffman RM. Direct external imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on internal organs in the fluorescent orthotopic model. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3824-9. PMID: 11891294.
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      236. Bouvet M, Wang J, Nardin SR, Nassirpour R, Yang M, Baranov E, Jiang P, Moossa AR, Hoffman RM. Real-time optical imaging of primary tumor growth and multiple metastatic events in a pancreatic cancer orthotopic model. Cancer Res. 2002 Mar 1; 62(5):1534-40. PMID: 11888932.
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      237. Bouvet M, Nardin SR, Burton DW, Behling C, Carethers JM, Moossa AR, Deftos LJ. Human pancreatic adenocarcinomas express parathyroid hormone-related protein. J Clin Endocrinol Metab. 2001 Jan; 86(1):310-6. PMID: 11232017.
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