Matthew Wortham

Title(s)	Assistant Adjunct Professor, Pediatrics
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

The role of LSD1 in adaptive insulin secretion
NIH/NIDDK F32DK102239Sep 18, 2014
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2. bioRxiv. 2024 Feb 28. Wortham M, Ramms B, Zeng C, Benthuysen JR, Sai S, Pollow DP, Liu F, Schlichting M, Harrington AR, Liu B, Prakash TP, Pirie EC, Zhu H, Baghdasarian S, Auwerx J, Shirihai OS, Sander M. PMID: 38464227; PMCID: PMC10925077.

View in: PubMed Mentions:
A vascularized 3D model of the human pancreatic islet forex vivostudy of immune cell-islet interaction. Biofabrication. 2024 Jan 11; 16(2). Bender RHF, O'Donnell BT, Shergill B, Pham BQ, Tahmouresie S, Sanchez CN, Juat DJ, Hatch MMS, Shirure VS, Wortham M, Nguyen-Ngoc KV, Jun Y, Gaetani R, Christman KL, Teyton L, George SC, Sander M, Hughes CCW. PMID: 38128127; PMCID: PMC10782895.

View in: PubMed Mentions: Fields:
Bio Biotechnology
Translation:Humans
Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding. Cell Death Dis. 2023 07 05; 14(7):399. Urizar AI, Prause M, Ingerslev LR, Wortham M, Sui Y, Sander M, Williams K, Barrès R, Larsen MR, Christensen GL, Billestrup N. PMID: 37407581; PMCID: PMC10322916.

View in: PubMed Mentions: Fields:
Cel Cell Biology Int Internal Medicine
Translation:Animals Cells
Nutrient regulation of the islet epigenome controls adaptive insulin secretion. J Clin Invest. 2023 04 17; 133(8). Wortham M, Liu F, Harrington AR, Fleischman JY, Wallace M, Mulas F, Mallick M, Vinckier NK, Cross BR, Chiou J, Patel NA, Sui Y, McGrail C, Jun Y, Wang G, Jhala US, Schüle R, Shirihai OS, Huising MO, Gaulton KJ, Metallo CM, Sander M. PMID: 36821378; PMCID: PMC10104905.

View in: PubMed Mentions: 7 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity. Diabetes. 2022 12 01; 71(12):2513-2529. Ramms B, Pollow DP, Zhu H, Nora C, Harrington AR, Omar I, Gordts PLSM, Wortham M, Sander M. PMID: 36162056; PMCID: PMC9750949.

View in: PubMed Mentions: 2 Fields:
End Endocrinology
Translation:Animals
Sizing up beta cells made from stem cells. Nat Biotechnol. 2022 07; 40(7):1006-1008. Nguyen-Ngoc KV, Wortham M, Sander M. PMID: 35288669.

View in: PubMed Mentions: 1 Fields:
Bio Biotechnology
Translation:Cells
Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance. Mol Metab. 2022 01; 55:101403. Shum M, Segawa M, Gharakhanian R, Viñuela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M. PMID: 34823065; PMCID: PMC8689243.

View in: PubMed Mentions: Fields:
Met Metabolism
Translation:Animals Cells
Endoplasmic reticulum tubules limit the size of misfolded protein condensates. Elife. 2021 09 01; 10. Parashar S, Chidambaram R, Chen S, Liem CR, Griffis E, Lambert GG, Shaner NC, Wortham M, Hay JC, Ferro-Novick S. PMID: 34467852; PMCID: PMC8486381.

View in: PubMed Mentions: 13 Fields:
Bio Biology
Translation:Humans Animals Cells
Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation. Trends Endocrinol Metab. 2021 07; 32(7):474-487. Wortham M, Sander M. PMID: 34030925; PMCID: PMC8259463.

View in: PubMed Mentions: 17 Fields:
End Endocrinology Met Metabolism
Translation:Cells
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Nat Commun. 2020 04 29; 11(1):2082. Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M. PMID: 32350257; PMCID: PMC7190832.

View in: PubMed Mentions: 13 Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1β is associated with changes in expression of beta-cell maturity genes and associated histone modifications. Mol Cell Endocrinol. 2019 10 01; 496:110524. Ibarra Urizar A, Prause M, Wortham M, Sui Y, Thams P, Sander M, Christensen GL, Billestrup N. PMID: 31362031.

View in: PubMed Mentions: 10 Fields:
Cel Cell Biology End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function. Cell Rep. 2018 12 04; 25(10):2904-2918.e8. Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. PMID: 30517875; PMCID: PMC6317899.

View in: PubMed Mentions: 31 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels. Tissue Eng Part C Methods. 2018 12; 24(12):697-708. Gaetani R, Aude S, DeMaddalena LL, Strassle H, Dzieciatkowska M, Wortham M, Bender RHF, Nguyen-Ngoc KV, Schmid-Schöenbein GW, George SC, Hughes CCW, Sander M, Hansen KC, Christman KL. PMID: 30398401; PMCID: PMC6306687.

View in: PubMed Mentions: 28 Fields:
Bio Biotechnology His Histology
Translation:Animals Cells
Mechanisms of β-cell functional adaptation to changes in workload. Diabetes Obes Metab. 2016 09; 18 Suppl 1:78-86. Wortham M, Sander M. PMID: 27615135; PMCID: PMC5021190.

View in: PubMed Mentions: 27 Fields:
End Endocrinology Met Metabolism
Translation:Humans Animals Cells
High T Gives β Cells a Boost. Cell Metab. 2016 May 10; 23(5):761-3. Wortham M, Sander M. PMID: 27166938.

View in: PubMed Mentions: 3 Fields:
Cel Cell Biology Met Metabolism
Translation:Humans Animals Cells
Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma. PLoS One. 2014; 9(9):e107156. Wortham M, Guo C, Zhang M, Song L, Lee BK, Iyer VR, Furey TS, Crawford GE, Yan H, He Y. PMID: 25198066; PMCID: PMC4157845.

View in: PubMed Mentions: 3 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17603-8. Guo C, Chang CC, Wortham M, Chen LH, Kernagis DN, Qin X, Cho YW, Chi JT, Grant GA, McLendon RE, Yan H, Ge K, Papadopoulos N, Bigner DD, He Y. PMID: 23045699; PMCID: PMC3491484.

View in: PubMed Mentions: 57 Fields:
Sci Science
Translation:Humans Cells
Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection. PLoS Genet. 2012 Jun; 8(6):e1002789. Shibata Y, Sheffield NC, Fedrigo O, Babbitt CC, Wortham M, Tewari AK, London D, Song L, Lee BK, Iyer VR, Parker SC, Margulies EH, Wray GA, Furey TS, Crawford GE. PMID: 22761590; PMCID: PMC3386175.

View in: PubMed Mentions: 73 Fields:
Gen Genetics
Translation:Humans Animals Cells
Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells. Cancer Discov. 2012 Jun; 2(6):492-4. Wortham M, Yan H. PMID: 22684456; PMCID: PMC3375910.

View in: PubMed Mentions: 1 Fields:
Neo Neoplasms
Translation:Humans Animals
Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells. PLoS One. 2012; 7(4):e36211. Wortham M, Jin G, Sun JL, Bigner DD, He Y, Yan H. PMID: 22558385; PMCID: PMC3338642.

View in: PubMed Mentions: 8 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas. Cancer Res. 2010 Jan 01; 70(1):181-91. Adamson DC, Shi Q, Wortham M, Northcott PA, Di C, Duncan CG, Li J, McLendon RE, Bigner DD, Taylor MD, Yan H. PMID: 20028867; PMCID: PMC2943736.

View in: PubMed Mentions: 60 Fields:
Neo Neoplasms
Translation:Humans Animals
The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. Dig Dis Sci. 2008 Oct; 53(10):2761-74. Wortham M, He L, Gyamfi M, Copple BL, Wan YJ. PMID: 18299981; PMCID: PMC3991247.

View in: PubMed Mentions: 30 Fields:
Gas Gastroenterology
Translation:Animals
Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver. Drug Metab Dispos. 2007 Sep; 35(9):1700-10. Wortham M, Czerwinski M, He L, Parkinson A, Wan YJ. PMID: 17576804.

View in: PubMed Mentions: 50 Fields:
Pha Pharmacology
Translation:Humans Cells