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    Masahiko Hoshijima

    TitleAssociate Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0608
    CA La Jolla 92093
    Phone858-822-3422
    vCardDownload vCard

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Funakoshi S, Miki K, Takaki T, Okubo C, Hatani T, Chonabayashi K, Nishikawa M, Takei I, Oishi A, Narita M, Hoshijima M, Kimura T, Yamanaka S, Yoshida Y. Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes. Sci Rep. 2016; 6:19111. PMID: 26743035.
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      2. Rajagopal V, Bass G, Walker CG, Crossman DJ, Petzer A, Hickey A, Siekmann I, Hoshijima M, Ellisman MH, Crampin EJ, Soeller C. Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes. PLoS Comput Biol. 2015 Sep; 11(9):e1004417. PMID: 26335304.
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      3. Nagata T, Yasukawa H, Kyogoku S, Oba T, Takahashi J, Nohara S, Minami T, Mawatari K, Sugi Y, Shimozono K, Pradervand S, Hoshijima M, Aoki H, Fukumoto Y, Imaizumi T. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules. PLoS One. 2015; 10(5):e0127942. PMID: 26010537.
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      4. Takeshima H, Hoshijima M, Song LS. Ca(2+) microdomains organized by junctophilins. Cell Calcium. 2015 Oct; 58(4):349-56. PMID: 25659516.
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      5. Ju WK, Kim KY, Noh YH, Hoshijima M, Lukas TJ, Ellisman MH, Weinreb RN, Perkins GA. Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes. Glia. 2015 May; 63(5):736-53. PMID: 25557093.
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      6. Kageyama Y, Hoshijima M, Seo K, Bedja D, Sysa-Shah P, Andrabi SA, Chen W, Höke A, Dawson VL, Dawson TM, Gabrielson K, Kass DA, Iijima M, Sesaki H. Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain. EMBO J. 2014 Dec 1; 33(23):2798-813. PMID: 25349190.
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      7. Yu Z, Wang J, Gao Z, Xu M, Hoshijima M. New software developments for quality mesh generation and optimization from biomedical imaging data. Comput Methods Programs Biomed. 2014 Jan; 113(1):226-40. PMID: 24252469.
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      8. Wong J, Baddeley D, Bushong EA, Yu Z, Ellisman MH, Hoshijima M, Soeller C. Nanoscale distribution of ryanodine receptors and caveolin-3 in mouse ventricular myocytes: dilation of t-tubules near junctions. Biophys J. 2013 Jun 4; 104(11):L22-4. PMID: 23746531.
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      9. Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. Novel role for vinculin in ventricular myocyte mechanics and dysfunction. Biophys J. 2013 Apr 2; 104(7):1623-33. PMID: 23561539.
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      10. Das T, Hoshijima M. Adding a new dimension to cardiac nano-architecture using electron microscopy: coupling membrane excitation to calcium signaling. J Mol Cell Cardiol. 2013 May; 58:5-12. PMID: 23201225.
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      11. Gawlowski T, Suarez J, Scott B, Torres-Gonzalez M, Wang H, Schwappacher R, Han X, Yates JR, Hoshijima M, Dillmann W. Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-ß-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes. J Biol Chem. 2012 Aug 24; 287(35):30024-34. PMID: 22745122.
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      12. Miyazaki Y, Ikeda Y, Shiraishi K, Fujimoto SN, Aoyama H, Yoshimura K, Inui M, Hoshijima M, Kasahara H, Aoki H, Matsuzaki M. Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling. PLoS One. 2012; 7(4):e35875. PMID: 22558250.
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      13. Hake J, Edwards AG, Yu Z, Kekenes-Huskey PM, Michailova AP, McCammon JA, Holst MJ, Hoshijima M, McCulloch AD. Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit. J Physiol. 2012 Sep 15; 590(Pt 18):4403-22. PMID: 22495592.
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      14. Oba T, Yasukawa H, Hoshijima M, Sasaki K, Futamata N, Fukui D, Mawatari K, Nagata T, Kyogoku S, Ohshima H, Minami T, Nakamura K, Kang D, Yajima T, Knowlton KU, Imaizumi T. Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction. J Am Coll Cardiol. 2012 Feb 28; 59(9):838-52. PMID: 22361405.
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      15. Yu Z, Yao G, Hoshijima M, Michailova A, Holst M. Multiscale modeling of calcium dynamics in ventricular myocytes with realistic transverse tubules. IEEE Trans Biomed Eng. 2011 Oct; 58(10):2947-51. PMID: 21632291.
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      16. Kitajima N, Watanabe K, Morimoto S, Sato Y, Kiyonaka S, Hoshijima M, Ikeda Y, Nakaya M, Ide T, Mori Y, Kurose H, Nishida M. TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts. Biochem Biophys Res Commun. 2011 May 27; 409(1):108-13. PMID: 21565173.
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      17. Maturana AD, Nakagawa N, Yoshimoto N, Tatematsu K, Hoshijima M, Tanizawa K, Kuroda S. LIM domains regulate protein kinase C activity: a novel molecular function. Cell Signal. 2011 May; 23(5):928-34. PMID: 21266195.
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      18. Hoshijima M, Hayashi T, Jeon YE, Fu Z, Gu Y, Dalton ND, Ellisman MH, Xiao X, Powell FL, Ross J. Delta-sarcoglycan gene therapy halts progression of cardiac dysfunction, improves respiratory failure, and prolongs life in myopathic hamsters. Circ Heart Fail. 2011 Jan; 4(1):89-97. PMID: 21036890.
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      19. Cheng Y, Yu Z, Hoshijima M, Holst MJ, McCulloch AD, McCammon JA, Michailova AP. Numerical analysis of Ca2+ signaling in rat ventricular myocytes with realistic transverse-axial tubular geometry and inhibited sarcoplasmic reticulum. PLoS Comput Biol. 2010; 6(10):e1000972. PMID: 21060856.
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      20. Nakano H, Williams E, Hoshijima M, Sasaki M, Minamisawa S, Chien KR, Nakano A. Cardiac origin of smooth muscle cells in the inflow tract. J Mol Cell Cardiol. 2011 Feb; 50(2):337-45. PMID: 20974149.
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      21. Gu Y, Zhang K, Biswas N, Friese RS, Lin DH, Mahata SK, Hoshijima M, O'Connor DT, Peterson KL, Brar BK. Urocortin 2 lowers blood pressure and reduces plasma catecholamine levels in mice with hyperadrenergic activity. Endocrinology. 2010 Oct; 151(10):4820-9. PMID: 20668031.
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      22. Yamazaki T, Wälchli S, Fujita T, Ryser S, Hoshijima M, Schlegel W, Kuroda S, Maturana AD. Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy. Cardiovasc Res. 2010 Jun 1; 86(3):374-82. PMID: 20097676.
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      23. Raskin AM, Hoshijima M, Swanson E, McCulloch AD, Omens JH. Hypertrophic gene expression induced by chronic stretch of excised mouse heart muscle. Mol Cell Biomech. 2009 Sep; 6(3):145-59. PMID: 19670825.
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      24. Hayashi T, Martone ME, Yu Z, Thor A, Doi M, Holst MJ, Ellisman MH, Hoshijima M. Three-dimensional electron microscopy reveals new details of membrane systems for Ca2+ signaling in the heart. J Cell Sci. 2009 Apr 1; 122(Pt 7):1005-13. PMID: 19295127.
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      25. Lu S, Michailova A, Saucerman J, Cheng Y, Yu Z, Kaiser T, Li W, Bank R, Holst M, McCammon J, Hayashi T, Hoshijima M, Arzberger P, McCulloch A. Multiscale modeling in rodent ventricular myocytes. IEEE Eng Med Biol Mag. 2009 Mar-Apr; 28(2):46-57. PMID: 19349251.
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      26. Yu Z, Holst MJ, Hayashi T, Bajaj CL, Ellisman MH, McCammon JA, Hoshijima M. Three-dimensional geometric modeling of membrane-bound organelles in ventricular myocytes: bridging the gap between microscopic imaging and mathematical simulation. J Struct Biol. 2008 Dec; 164(3):304-13. PMID: 18835449.
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      27. Maturana AD, Wälchli S, Iwata M, Ryser S, Van Lint J, Hoshijima M, Schlegel W, Ikeda Y, Tanizawa K, Kuroda S. Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel. Cardiovasc Res. 2008 Jun 1; 78(3):458-65. PMID: 18296710.
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      28. Ikeda Y, Hoshijima M, Chien KR. Toward biologically targeted therapy of calcium cycling defects in heart failure. Physiology (Bethesda). 2008 Feb; 23:6-16. PMID: 18268360.
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      29. Kaye DM, Hoshijima M, Chien KR. Reversing advanced heart failure by targeting Ca2+ cycling. Annu Rev Med. 2008; 59:13-28. PMID: 18186701.
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      30. Kaye DM, Preovolos A, Marshall T, Byrne M, Hoshijima M, Hajjar R, Mariani JA, Pepe S, Chien KR, Power JM. Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals. J Am Coll Cardiol. 2007 Jul 17; 50(3):253-60. PMID: 17631218.
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      31. Muto M, Sargeant A, Tangkawattana P, Takeyasu K, Nishijima Y, Bonagura J, Hoshijima M, Nakade T, Hosaka Y, Faulkner G, Tomono K, Yamaguchi M. Intranuclear paracrystals observed in striated muscle specific LIM protein-deficient mouse cardiomyocytes. Microsc Res Tech. 2007 Jan; 70(1):50-4. PMID: 17094078.
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      32. Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton KU. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 2006 Nov 28; 114(22):2364-73. PMID: 17101849.
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      33. Hoshijima M, Knöll R, Pashmforoush M, Chien KR. Reversal of calcium cycling defects in advanced heart failure toward molecular therapy. J Am Coll Cardiol. 2006 Nov 7; 48(9 Suppl 1):A15-23. PMID: 17084280.
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      34. Boateng SY, Belin RJ, Geenen DL, Margulies KB, Martin JL, Hoshijima M, de Tombe PP, Russell B. Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H259-69. PMID: 16963613.
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      35. Hoshijima M. Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures. Am J Physiol Heart Circ Physiol. 2006 Apr; 290(4):H1313-25. PMID: 16537787.
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      36. St Amand TR, Lu JT, Zamora M, Gu Y, Stricker J, Hoshijima M, Epstein JA, Ross JJ, Ruiz-Lozano P, Chien KR. Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Dev Biol. 2006 Mar 15; 291(2):208-17. PMID: 16430881.
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      37. Wang J, Hoshijima M, Lam J, Zhou Z, Jokiel A, Dalton ND, Hultenby K, Ruiz-Lozano P, Ross J, Tryggvason K, Chien KR. Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice. J Biol Chem. 2006 Jan 6; 281(1):213-20. PMID: 16204254.
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      38. Lorenzen-Schmidt I, Stuyvers BD, ter Keurs HE, Date MO, Hoshijima M, Chien KR, McCulloch AD, Omens JH. Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. J Mol Cell Cardiol. 2005 Aug; 39(2):241-50. PMID: 15978612.
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      39. Hu Y, Belke D, Suarez J, Swanson E, Clark R, Hoshijima M, Dillmann WH. Adenovirus-mediated overexpression of O-GlcNAcase improves contractile function in the diabetic heart. Circ Res. 2005 May 13; 96(9):1006-13. PMID: 15817886.
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      40. Iwata M, Maturana A, Hoshijima M, Tatematsu K, Okajima T, Vandenheede JR, Van Lint J, Tanizawa K, Kuroda S. PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists. Biochem Biophys Res Commun. 2005 Feb 25; 327(4):1105-13. PMID: 15652511.
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      41. Hoshijima M. Gene therapy targeted at calcium handling as an approach to the treatment of heart failure. Pharmacol Ther. 2005 Mar; 105(3):211-28. PMID: 15737405.
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      42. Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien KR, Ishikawa Y, Matsuoka R. Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun. 2004 Dec 17; 325(3):852-6. PMID: 15541368.
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      43. Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Choi BY, Bae SW, You CW, Han KH, Park JE, Knöll R, Hoshijima M, Chien KR, Kimura A. Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol. 2004 Dec 7; 44(11):2192-201. PMID: 15582318.
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      44. Pradervand S, Yasukawa H, Muller OG, Kjekshus H, Nakamura T, St Amand TR, Yajima T, Matsumura K, Duplain H, Iwatate M, Woodard S, Pedrazzini T, Ross J, Firsov D, Rossier BC, Hoshijima M, Chien KR. Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein. EMBO J. 2004 Nov 10; 23(22):4517-25. PMID: 15510217.
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      45. Chien KR, Hoshijima M. Unravelling Ras signals in cardiovascular disease. Nat Cell Biol. 2004 Sep; 6(9):807-8. PMID: 15340447.
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      46. Hoshijima M. Models of dilated cardiomyopathy in small animals and novel positive inotropic therapies. Ann N Y Acad Sci. 2004 May; 1015:320-31. PMID: 15201171.
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      47. Iwanaga Y, Hoshijima M, Gu Y, Iwatate M, Dieterle T, Ikeda Y, Date MO, Chrast J, Matsuzaki M, Peterson KL, Chien KR, Ross J. Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. J Clin Invest. 2004 Mar; 113(5):727-36. PMID: 14991071.
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      48. Bale TL, Hoshijima M, Gu Y, Dalton N, Anderson KR, Lee KF, Rivier J, Chien KR, Vale WW, Peterson KL. The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. Proc Natl Acad Sci U S A. 2004 Mar 9; 101(10):3697-702. PMID: 14990799.
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      49. Knöll R, Hoshijima M, Chien K. Cardiac mechanotransduction and implications for heart disease. J Mol Med (Berl). 2003 Dec; 81(12):750-6. PMID: 14551702.
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      50. Iwatate M, Gu Y, Dieterle T, Iwanaga Y, Peterson KL, Hoshijima M, Chien KR, Ross J. In vivo high-efficiency transcoronary gene delivery and Cre-LoxP gene switching in the adult mouse heart. Gene Ther. 2003 Oct; 10(21):1814-20. PMID: 12960971.
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      51. Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, Yoshimura A. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol. 2003 Jun; 4(6):551-6. PMID: 12754507.
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      52. Chien KR, Ross J, Hoshijima M. Calcium and heart failure: the cycle game. Nat Med. 2003 May; 9(5):508-9. PMID: 12724757.
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      53. Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng. 2003 Mar 5; 81(5):578-87. PMID: 12514807.
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      54. Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest. 2003 Feb; 111(4):469-78. PMID: 12588885.
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      55. Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002 Dec 27; 111(7):943-55. PMID: 12507422.
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      56. Hoshijima M, Ikeda Y, Iwanaga Y, Minamisawa S, Date MO, Gu Y, Iwatate M, Li M, Wang L, Wilson JM, Wang Y, Ross J, Chien KR. Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med. 2002 Aug; 8(8):864-71. PMID: 12134142.
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      57. Hoshijima M, Chien KR. Mixed signals in heart failure: cancer rules. J Clin Invest. 2002 Apr; 109(7):849-55. PMID: 11927610.
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      58. Ikeda Y, Gu Y, Iwanaga Y, Hoshijima M, Oh SS, Giordano FJ, Chen J, Nigro V, Peterson KL, Chien KR, Ross J. Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer. Circulation. 2002 Jan 29; 105(4):502-8. PMID: 11815435.
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      59. Hoshijima M, Pashmforoush M, Knöll R, Chien KR. The MLP family of cytoskeletal Z disc proteins and dilated cardiomyopathy: a stress pathway model for heart failure progression. Cold Spring Harb Symp Quant Biol. 2002; 67:399-408. PMID: 12858565.
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      60. Knöll R, Hoshijima M, Chien KR. Muscle LIM protein in heart failure. Exp Clin Cardiol. 2002; 7(2-3):104-5. PMID: 19649232.
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      61. Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyêñ-Trân VT, Gu Y, Ikeda Y, Chu PH, Ross J, Giles WR, Chien KR. A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell. 2001 Dec 14; 107(6):801-13. PMID: 11747815.
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      62. Morishige K, Shimokawa H, Eto Y, Hoshijima M, Kaibuchi K, Takeshita A. In vivo gene transfer of dominant-negative rho-kinase induces regression of coronary arteriosclerosis in pigs. Ann N Y Acad Sci. 2001 Dec; 947:407-11. PMID: 11795302.
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      63. Yasukawa H, Hoshijima M, Gu Y, Nakamura T, Pradervand S, Hanada T, Hanakawa Y, Yoshimura A, Ross J, Chien KR. Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. J Clin Invest. 2001 Nov; 108(10):1459-67. PMID: 11714737.
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      64. Morishige K, Shimokawa H, Eto Y, Kandabashi T, Miyata K, Matsumoto Y, Hoshijima M, Kaibuchi K, Takeshita A. Adenovirus-mediated transfer of dominant-negative rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo. Arterioscler Thromb Vasc Biol. 2001 Apr; 21(4):548-54. PMID: 11304471.
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      65. Meiyanto E, Hoshijima M, Ogawa T, Ishida N, Takeya T. Osteoclast differentiation factor modulates cell cycle machinery and causes a delay in s phase progression in RAW264 cells. Biochem Biophys Res Commun. 2001 Mar 23; 282(1):278-83. PMID: 11264004.
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      66. Nakagawa N, Hoshijima M, Oyasu M, Saito N, Tanizawa K, Kuroda S. ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain. Biochem Biophys Res Commun. 2000 Jun 7; 272(2):505-12. PMID: 10833443.
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      67. Eto Y, Shimokawa H, Hiroki J, Morishige K, Kandabashi T, Matsumoto Y, Amano M, Hoshijima M, Kaibuchi K, Takeshita A. Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs. Am J Physiol Heart Circ Physiol. 2000 Jun; 278(6):H1744-50. PMID: 10843868.
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      68. Ikeda Y, Martone M, Gu Y, Hoshijima M, Thor A, Oh SS, Peterson KL, Ross J. Altered membrane proteins and permeability correlate with cardiac dysfunction in cardiomyopathic hamsters. Am J Physiol Heart Circ Physiol. 2000 Apr; 278(4):H1362-70. PMID: 10749734.
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      69. Minamisawa S, Hoshijima M, Chu G, Ward CA, Frank K, Gu Y, Martone ME, Wang Y, Ross J, Kranias EG, Giles WR, Chien KR. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell. 1999 Oct 29; 99(3):313-22. PMID: 10555147.
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      70. Hoshijima M, Sah VP, Wang Y, Chien KR, Brown JH. The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase. J Biol Chem. 1998 Mar 27; 273(13):7725-30. PMID: 9516480.
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      71. Sheng Z, Knowlton K, Chen J, Hoshijima M, Brown JH, Chien KR. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy. J Biol Chem. 1997 Feb 28; 272(9):5783-91. PMID: 9038192.
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      72. Chien KR, Shimizu M, Hoshijima M, Minamisawa S, Grace AA. Toward molecular strategies for heart disease--past, present, future. Jpn Circ J. 1997 Feb; 61(2):91-118. PMID: 9070966.
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      73. Sah VP, Hoshijima M, Chien KR, Brown JH. Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. J Biol Chem. 1996 Dec 6; 271(49):31185-90. PMID: 8940118.
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      74. Okuda M, Kawahara Y, Nakayama I, Hoshijima M, Yokoyama M. Angiotensin II transduces its signal to focal adhesions via angiotensin II type 1 receptors in vascular smooth muscle cells. FEBS Lett. 1995 Jul 17; 368(2):343-7. PMID: 7628634.
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      75. Hoshijima M, Kondo J, Kikuchi A, Yamamoto K, Takai Y. Purification and characterization from bovine brain membranes of a GTP-binding protein with a Mr of 21,000, ADP-ribosylated by an ADP-ribosyltransferase contaminated in botulinum toxin type C1--identification as the rhoA gene product. Brain Res Mol Brain Res. 1990 Jan; 7(1):9-16. PMID: 2153899.
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      76. Kawata M, Kikuchi A, Hoshijima M, Yamamoto K, Hashimoto E, Yamamura H, Takai Y. Phosphorylation of smg p21, a ras p21-like GTP-binding protein, by cyclic AMP-dependent protein kinase in a cell-free system and in response to prostaglandin E1 in intact human platelets. J Biol Chem. 1989 Sep 15; 264(26):15688-95. PMID: 2504724.
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      77. Adachi M, Ryo R, Yoshida A, Teshigawara K, Yamaguchi N, Hoshijima M, Takai Y, Sato T. Elevation of intracellular calcium ion by prostaglandin E1 and its inhibition by protein kinase C in a human megakaryocyte leukemia cell line. Cancer Res. 1989 Jul 15; 49(14):3805-8. PMID: 2736522.
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      78. Hoshijima M, Kikuchi A, Kawata M, Ohmori T, Hashimoto E, Yamamura H, Takai Y. Phosphorylation by cyclic AMP-dependent protein kinase of a human platelet Mr 22,000 GTP-binding protein (smg p21) having the same putative effector domain as the ras gene products. Biochem Biophys Res Commun. 1988 Dec 30; 157(3):851-60. PMID: 2849942.
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      79. Hoshijima M, Ueda T, Hamamori Y, Ohmori T, Takai Y. Different sensitivity to phorbol esters and pertussis toxin of bombesin- and platelet-derived growth factor-induced, phospholipase C-mediated hydrolysis of phosphoinositides in NIH/3T3 cells. Biochem Biophys Res Commun. 1988 Apr 15; 152(1):285-93. PMID: 2833889.
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      80. Tanimoto T, Hoshijima M, Kawata M, Yamamoto K, Ohmori T, Shiku H, Nakano H, Takai Y. Binding of ras p21 to bands 4.2 and 6 of human erythrocyte membranes. FEBS Lett. 1988 Jan 4; 226(2):291-6. PMID: 3276554.
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      81. Kozawa O, Hoshijima M, Tanimoto T, Ohmori T, Takai Y. Similar physical and kinetic properties of rat brain synaptic membrane and cytosol phosphoinositide phospholipases C. Biochem Biophys Res Commun. 1987 May 29; 145(1):218-27. PMID: 3036120.
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      82. Hoshijima M, Kikuchi A, Tanimoto T, Kaibuchi K, Takai Y. Formation of a phorbol ester-binding fragment from protein kinase C by proteolytic digestion. Cancer Res. 1986 Jun; 46(6):3000-4. PMID: 3084081.
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      83. Kawahara Y, Fukuzaki H, Kaibuchi K, Tsuda T, Hoshijima M, Takai Y. Activation of protein kinase C by the action of 9,11-epithio-11,12-methano-thromboxane A2 (STA2), a stable analogue of thromboxane A2, in human platelets. Thromb Res. 1986 Mar 15; 41(6):811-8. PMID: 3010491.
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