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    Marygorret Obonyo

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0640
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      MyD88-dependent mechanisms of Helicobacter pylori-induced gastric cancer progression
      NIH/NCI R21CA210227Mar 3, 2017 - Feb 28, 2019
      Role: Principal Investigator
      Role of inflammatory microenvironment in Helicobacter-induced gastric cancer
      NIH/NCI R21CA188752Apr 1, 2015 - Mar 31, 2017
      Role: Principal Investigator
      Immunological Basis for H. Pylori-Related Malignancies
      NIH/NCI K01CA096709Sep 1, 2002 - Aug 31, 2008
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lozano-Pope I, Sharma A, Matthias M, Doran KS, Obonyo M. Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer. BMC Cancer. 2017 Feb 15; 17(1):133. PMID: 28201999.
        View in: PubMed
      2. King CC, Obonyo M. Helicobacter pylori modulates host cell survival regulation through the serine-threonine kinase, 3-phosphoinositide dependent kinase 1 (PDK-1). BMC Microbiol. 2015 Oct 21; 15:222. PMID: 26487493; PMCID: PMC4618363.
      3. Jung SW, Thamphiwatana S, Zhang L, Obonyo M. Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori. PLoS One. 2015; 10(3):e0116519. PMID: 25793403; PMCID: PMC4368202.
      4. Thamphiwatana S, Gao W, Pornpattananangkul D, Zhang Q, Fu V, Li J, Li J, Obonyo M, Zhang L. Phospholipase A2-responsive antibiotic delivery via nanoparticle-stabilized liposomes for the treatment of bacterial infection. J Mater Chem B Mater Biol Med. 2014 Dec 14; 2(46):8201-8207. PMID: 25544886.
        View in: PubMed
      5. Thamphiwatana S, Gao W, Obonyo M, Zhang L. In vivo treatment of Helicobacter pylori infection with liposomal linolenic acid reduces colonization and ameliorates inflammation. Proc Natl Acad Sci U S A. 2014 Dec 09; 111(49):17600-5. PMID: 25422427; PMCID: PMC4267350.
      6. Banerjee A, Thamphiwatana S, Carmona EM, Rickman B, Doran KS, Obonyo M. Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy. Infect Immun. 2014 Jan; 82(1):356-63. PMID: 24166959; PMCID: PMC3911874.
      7. Obonyo M, Zhang L, Thamphiwatana S, Pornpattananangkul D, Fu V, Zhang L. Antibacterial activities of liposomal linolenic acids against antibiotic-resistant Helicobacter pylori. Mol Pharm. 2012 Sep 04; 9(9):2677-85. PMID: 22827534; PMCID: PMC3433584.
      8. Obonyo M, Rickman B, Guiney DG. Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response. Helicobacter. 2011 Oct; 16(5):398-404. PMID: 21923686; PMCID: PMC3535435.
      9. Pornpattananangkul D, Zhang L, Olson S, Aryal S, Obonyo M, Vecchio K, Huang CM, Zhang L. Bacterial toxin-triggered drug release from gold nanoparticle-stabilized liposomes for the treatment of bacterial infection. J Am Chem Soc. 2011 Mar 23; 133(11):4132-9. PMID: 21344925; PMCID: PMC3062754.
      10. Hernandez M, Leichtle A, Pak K, Ebmeyer J, Euteneuer S, Obonyo M, Guiney DG, Webster NJ, Broide DH, Ryan AF, Wasserman SI. Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. J Infect Dis. 2008 Dec 15; 198(12):1862-9. PMID: 18986247; PMCID: PMC3584630.
      11. Obonyo M, Sabet M, Cole SP, Ebmeyer J, Uematsu S, Akira S, Guiney DG. Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori. Infect Immun. 2007 May; 75(5):2408-14. PMID: 17353291; PMCID: PMC1865764.
      12. Obonyo M, Cole SP, Datta SK, Guiney DG. Evidence for interleukin-1-independent stimulation of interleukin-12 and down-regulation by interleukin-10 in Helicobacter pylori-infected murine dendritic cells deficient in the interleukin-1 receptor. FEMS Immunol Med Microbiol. 2006 Aug; 47(3):414-9. PMID: 16872378.
        View in: PubMed
      13. Hase K, Murakami M, Iimura M, Cole SP, Horibe Y, Ohtake T, Obonyo M, Gallo RL, Eckmann L, Kagnoff MF. Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology. 2003 Dec; 125(6):1613-25. PMID: 14724813.
        View in: PubMed
      14. Obonyo M, Guiney DG, Fierer J, Cole SP. Interactions between inducible nitric oxide and other inflammatory mediators during Helicobacter pylori infection. Helicobacter. 2003; 8(5):495-502. PMID: 14535996.
        View in: PubMed
      15. Obonyo M, Guiney DG, Harwood J, Fierer J, Cole SP. Role of gamma interferon in Helicobacter pylori induction of inflammatory mediators during murine infection. Infect Immun. 2002 Jun; 70(6):3295-9. PMID: 12011029; PMCID: PMC127973.
      16. Obonyo M, Munderloh UG, Sam TN, Kurtti TJ. Cultivation at 37 degrees C enhances Borrelia burgdorferi sensu stricto infectivity for hamsters. Med Microbiol Immunol. 2002 May; 191(1):33-9. PMID: 12137197.
        View in: PubMed
      17. Laurila A, Cole SP, Merat S, Obonyo M, Palinski W, Fierer J, Witztum JL. High-fat, high-cholesterol diet increases the incidence of gastritis in LDL receptor-negative mice. Arterioscler Thromb Vasc Biol. 2001 Jun; 21(6):991-6. PMID: 11397709.
        View in: PubMed
      18. Obonyo M, Munderloh UG, Fingerle V, Wilske B, Kurtti TJ. Borrelia burgdorferi in tick cell culture modulates expression of outer surface proteins A and C in response to temperature. J Clin Microbiol. 1999 Jul; 37(7):2137-41. PMID: 10364575; PMCID: PMC85101.
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