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    Martyn Goulding

    Address9500 Gilman Drive #0932
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Revealing the connectivity and functionality of brain stem circuits
      NIH/NINDS U01NS090595Sep 30, 2014 - Jul 31, 2017
      Role: Principal Investigator
      Spinal cord neural circuits for left-right and flexor-extensor coordination
      NIH/NINDS R01NS090919Sep 15, 2014 - Jul 31, 2019
      Role: Principal Investigator
      Intersectional genetic dissection of spinal circuits processing pain and itch
      NIH/NINDS R01NS086372Sep 30, 2013 - Jun 30, 2018
      Role: Principal Investigator
      Sensory and Supraspinal Control of Locomotion
      NIH/NINDS R01NS080586Feb 15, 2013 - Jan 31, 2018
      Role: Principal Investigator
      Tools for Mapping Mammalian Nervous System Connections with Modified Rabies Virus
      NIH/NINDS RC2NS069464Sep 30, 2009 - Aug 31, 2012
      Role: Principal Investigator
      Diversification and Function of Spinal V2b-Derived Neurons
      NIH/FIC R03TW008026Aug 1, 2008 - Apr 30, 2012
      Role: Principal Investigator
      Functional Analysis of Inhibitory Spinal Cord Interneurons
      NIH/NINDS R37NS037075Apr 1, 1998 - Mar 31, 2013
      Role: Principal Investigator
      Functional Analysis of Spinal Cord Interneurons
      NIH/NINDS R01NS037075Apr 1, 1998 - Aug 14, 2006
      Role: Principal Investigator
      Specification of Dorsal Lbx1-Derived Interneurons
      NIH/NINDS R01NS031978Aug 1, 1993 - Apr 30, 2008
      Role: Principal Investigator
      Molecular Determinants of Neural Development
      NIH/NINDS P01NS031249Jan 1, 1993 - Mar 31, 2012
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Sternfeld MJ, Hinckley CA, Moore NJ, Pankratz MT, Hilde KL, Driscoll SP, Hayashi M, Amin ND, Bonanomi D, Gifford WD, Sharma K, Goulding M, Pfaff SL. Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells. Elife. 2017 Feb 14; 6. PMID: 28195039.
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      2. Flynn JR, Conn VL, Boyle KA, Hughes DI, Watanabe M, Velasquez T, Goulding M, Callister RJ, Graham BA. Anatomical and Molecular Properties of Long Descending Propriospinal Neurons in Mice. Front Neuroanat. 2017; 11:5. PMID: 28220062.
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      3. Tuncdemir SN, Wamsley B, Stam FJ, Osakada F, Goulding M, Callaway EM, Rudy B, Fishell G. Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits. Neuron. 2016 Feb 3; 89(3):521-35. PMID: 26844832.
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      4. Britz O, Zhang J, Grossmann KS, Dyck J, Kim JC, Dymecki S, Gosgnach S, Goulding M. Correction: A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements. Elife. 2015; 4. PMID: 26606138.
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      5. Bourane S, Duan B, Koch SC, Dalet A, Britz O, Garcia-Campmany L, Kim E, Cheng L, Ghosh A, Ma Q, Goulding M. Gate control of mechanical itch by a subpopulation of spinal cord interneurons. Science. 2015 Oct 30; 350(6260):550-4. PMID: 26516282.
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      6. Britz O, Zhang J, Grossmann KS, Dyck J, Kim JC, Dymecki S, Gosgnach S, Goulding M. A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements. Elife. 2015; 4. PMID: 26465208.
        View in: PubMed
      7. Bourane S, Grossmann KS, Britz O, Dalet A, Del Barrio MG, Stam FJ, Garcia-Campmany L, Koch S, Goulding M. Identification of a spinal circuit for light touch and fine motor control. Cell. 2015 Jan 29; 160(3):503-15. PMID: 25635458.
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      8. Duan B, Cheng L, Bourane S, Britz O, Padilla C, Garcia-Campmany L, Krashes M, Knowlton W, Velasquez T, Ren X, Ross SE, Lowell BB, Wang Y, Goulding M, Ma Q. Identification of spinal circuits transmitting and gating mechanical pain. Cell. 2014 Dec 4; 159(6):1417-32. PMID: 25467445.
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      9. Carcagno AL, Di Bella DJ, Goulding M, Guillemot F, Lanuza GM. Neurogenin3 restricts serotonergic neuron differentiation to the hindbrain. J Neurosci. 2014 Nov 12; 34(46):15223-33. PMID: 25392491.
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      10. Hatori M, Gill S, Mure LS, Goulding M, O'Leary DD, Panda S. Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. Elife. 2014; 3:e03357. PMID: 25035422.
        View in: PubMed
      11. Goulding M, Bourane S, Garcia-Campmany L, Dalet A, Koch S. Inhibition downunder: an update from the spinal cord. Curr Opin Neurobiol. 2014 Jun; 26:161-6. PMID: 24743058.
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      12. Zhang J, Lanuza GM, Britz O, Wang Z, Siembab VC, Zhang Y, Velasquez T, Alvarez FJ, Frank E, Goulding M. V1 and v2b interneurons secure the alternating flexor-extensor motor activity mice require for limbed locomotion. Neuron. 2014 Apr 2; 82(1):138-50. PMID: 24698273.
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      13. Borowska J, Jones CT, Zhang H, Blacklaws J, Goulding M, Zhang Y. Functional subpopulations of v3 interneurons in the mature mouse spinal cord. J Neurosci. 2013 Nov 20; 33(47):18553-65. PMID: 24259577.
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      14. Del Barrio MG, Bourane S, Grossmann K, Schüle R, Britsch S, O'Leary DD, Goulding M. A transcription factor code defines nine sensory interneuron subtypes in the mechanosensory area of the spinal cord. PLoS One. 2013; 8(11):e77928. PMID: 24223744.
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      15. Francius C, Harris A, Rucchin V, Hendricks TJ, Stam FJ, Barber M, Kurek D, Grosveld FG, Pierani A, Goulding M, Clotman F. Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord. PLoS One. 2013; 8(8):e70325. PMID: 23967072.
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      16. Li Y, Stam FJ, Aimone JB, Goulding M, Callaway EM, Gage FH. Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9106-11. PMID: 23671081.
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      17. Goulding M. Motor neurons that multitask. Neuron. 2012 Nov 21; 76(4):669-70. PMID: 23177952.
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      18. Ikrar T, Shi Y, Velasquez T, Goulding M, Xu X. Cell-type specific regulation of cortical excitability through the allatostatin receptor system. Front Neural Circuits. 2012; 6:2. PMID: 22319474.
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      19. Stam FJ, Hendricks TJ, Zhang J, Geiman EJ, Francius C, Labosky PA, Clotman F, Goulding M. Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program. Development. 2012 Jan; 139(1):179-90. PMID: 22115757.
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      20. Garcia-Campmany L, Stam FJ, Goulding M. From circuits to behaviour: motor networks in vertebrates. Curr Opin Neurobiol. 2010 Feb; 20(1):116-25. PMID: 20138753.
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      21. Grossmann KS, Giraudin A, Britz O, Zhang J, Goulding M. Genetic dissection of rhythmic motor networks in mice. Prog Brain Res. 2010; 187:19-37. PMID: 21111198.
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      22. Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH, Ang SL. Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. Dev Biol. 2009 Sep 15; 333(2):386-96. PMID: 19607821.
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      23. Goulding M. Circuits controlling vertebrate locomotion: moving in a new direction. Nat Rev Neurosci. 2009 Jul; 10(7):507-18. PMID: 19543221.
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      24. Pagliardini S, Ren J, Gray PA, Vandunk C, Gross M, Goulding M, Greer JJ. Central respiratory rhythmogenesis is abnormal in lbx1- deficient mice. J Neurosci. 2008 Oct 22; 28(43):11030-41. PMID: 18945911.
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      25. Zhang Y, Narayan S, Geiman E, Lanuza GM, Velasquez T, Shanks B, Akay T, Dyck J, Pearson K, Gosgnach S, Fan CM, Goulding M. V3 spinal neurons establish a robust and balanced locomotor rhythm during walking. Neuron. 2008 Oct 9; 60(1):84-96. PMID: 18940590.
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      26. Wang Z, Li L, Goulding M, Frank E. Early postnatal development of reciprocal Ia inhibition in the murine spinal cord. J Neurophysiol. 2008 Jul; 100(1):185-96. PMID: 18463181.
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      27. Xu Y, Lopes C, Qian Y, Liu Y, Cheng L, Goulding M, Turner EE, Lima D, Ma Q. Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons. J Neurosci. 2008 Apr 9; 28(15):4037-46. PMID: 18400903.
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      28. Pillai A, Mansouri A, Behringer R, Westphal H, Goulding M. Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. Development. 2007 Jan; 134(2):357-66. PMID: 17166926.
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      29. Tan EM, Yamaguchi Y, Horwitz GD, Gosgnach S, Lein ES, Goulding M, Albright TD, Callaway EM. Selective and quickly reversible inactivation of mammalian neurons in vivo using the Drosophila allatostatin receptor. Neuron. 2006 Jul 20; 51(2):157-70. PMID: 16846851.
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      30. Mizuguchi R, Kriks S, Cordes R, Gossler A, Ma Q, Goulding M. Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons. Nat Neurosci. 2006 Jun; 9(6):770-8. PMID: 16715081.
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      31. Gosgnach S, Lanuza GM, Butt SJ, Saueressig H, Zhang Y, Velasquez T, Riethmacher D, Callaway EM, Kiehn O, Goulding M. V1 spinal neurons regulate the speed of vertebrate locomotor outputs. Nature. 2006 Mar 9; 440(7081):215-9. PMID: 16525473.
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      32. Nakahira E, Kagawa T, Shimizu T, Goulding M, Ikenaka K. Direct evidence that ventral forebrain cells migrate to the cortex and contribute to the generation of cortical myelinating oligodendrocytes. Dev Biol. 2006 Mar 1; 291(1):123-31. PMID: 16413527.
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      33. Quina LA, Pak W, Lanier J, Banwait P, Gratwick K, Liu Y, Velasquez T, O'Leary DD, Goulding M, Turner EE. Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways. J Neurosci. 2005 Dec 14; 25(50):11595-604. PMID: 16354917.
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      34. Alvarez FJ, Jonas PC, Sapir T, Hartley R, Berrocal MC, Geiman EJ, Todd AJ, Goulding M. Postnatal phenotype and localization of spinal cord V1 derived interneurons. J Comp Neurol. 2005 Dec 12; 493(2):177-92. PMID: 16255029.
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      35. Cheng L, Samad OA, Xu Y, Mizuguchi R, Luo P, Shirasawa S, Goulding M, Ma Q. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nat Neurosci. 2005 Nov; 8(11):1510-5. PMID: 16234809.
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      36. Kriks S, Lanuza GM, Mizuguchi R, Nakafuku M, Goulding M. Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord. Development. 2005 Jul; 132(13):2991-3002. PMID: 15930101.
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      37. Goulding M, Pfaff SL. Development of circuits that generate simple rhythmic behaviors in vertebrates. Curr Opin Neurobiol. 2005 Feb; 15(1):14-20. PMID: 15721739.
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      38. Goulding M. How early is firing required for wiring? Neuron. 2004 Sep 2; 43(5):601-3. PMID: 15339640.
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      39. Goulding M. Neurobiology: a matter of balance. Nature. 2004 Jun 3; 429(6991):515-7. PMID: 15175736.
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      40. Lanuza GM, Gosgnach S, Pierani A, Jessell TM, Goulding M. Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements. Neuron. 2004 May 13; 42(3):375-86. PMID: 15134635.
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      41. Sapir T, Geiman EJ, Wang Z, Velasquez T, Mitsui S, Yoshihara Y, Frank E, Alvarez FJ, Goulding M. Pax6 and engrailed 1 regulate two distinct aspects of renshaw cell development. J Neurosci. 2004 Feb 4; 24(5):1255-64. PMID: 14762144.
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      42. Goulding M, Lanuza G, Sapir T, Narayan S. The formation of sensorimotor circuits. Curr Opin Neurobiol. 2002 Oct; 12(5):508-15. PMID: 12367629.
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      43. Gross MK, Dottori M, Goulding M. Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. Neuron. 2002 May 16; 34(4):535-49. PMID: 12062038.
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      44. Dottori M, Gross MK, Labosky P, Goulding M. The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate. Development. 2001 Nov; 128(21):4127-38. PMID: 11684651.
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      45. Simon HH, Saueressig H, Wurst W, Goulding M, O'Leary DD. Fate of midbrain dopaminergic neurons controlled by the engrailed genes. J Neurosci. 2001 May 1; 21(9):3126-34. PMID: 11312297.
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      46. Lamar E, Kintner C, Goulding M. Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation. Development. 2001 Apr; 128(8):1335-46. PMID: 11262234.
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      47. Pierani A, Moran-Rivard L, Sunshine MJ, Littman DR, Goulding M, Jessell TM. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. Neuron. 2001 Feb; 29(2):367-84. PMID: 11239429.
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      48. Moran-Rivard L, Kagawa T, Saueressig H, Gross MK, Burrill J, Goulding M. Evx1 is a postmitotic determinant of v0 interneuron identity in the spinal cord. Neuron. 2001 Feb; 29(2):385-99. PMID: 11239430.
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      49. Nicholson LF, Ma L, Goulding M. Cloning and expression of Munc 30: a member of the paired -like homeodomain gene family. Cell Biol Int. 2001; 25(4):351-65. PMID: 11319841.
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      50. Goulding M, Lamar E. Neuronal patterning: Making stripes in the spinal cord. Curr Biol. 2000 Jul 27-Aug 10; 10(15):R565-8. PMID: 10959831.
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      51. Mah SP, Saueressig H, Goulding M, Kintner C, Dressler GR. Kidney development in cadherin-6 mutants: delayed mesenchyme-to-epithelial conversion and loss of nephrons. Dev Biol. 2000 Jul 1; 223(1):38-53. PMID: 10864459.
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      52. Gross MK, Moran-Rivard L, Velasquez T, Nakatsu MN, Jagla K, Goulding M. Lbx1 is required for muscle precursor migration along a lateral pathway into the limb. Development. 2000 Jan; 127(2):413-24. PMID: 10603357.
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      53. Saueressig H, Burrill J, Goulding M. Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons. Development. 1999 Oct; 126(19):4201-12. PMID: 10477289.
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      54. Bang AG, Papalopulu N, Goulding M, Kintner C. Expression of Pax-3 in the lateral neural plate is dependent on a Wnt-mediated signal from posterior nonaxial mesoderm. Dev Biol. 1999 Aug 15; 212(2):366-80. PMID: 10433827.
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      55. Goulding M. Specifying motor neurons and their connections. Neuron. 1998 Nov; 21(5):943-6. PMID: 9856450.
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      56. Burrill JD, Moran L, Goulding M, Saueressig H. PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development. Development. 1997 Nov; 124(22):4493-503. PMID: 9409667.
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      57. McWhirter JR, Goulding M, Weiner JA, Chun J, Murre C. A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development. 1997 Sep; 124(17):3221-32. PMID: 9310317.
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      58. Bang AG, Papalopulu N, Kintner C, Goulding M. Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm. Development. 1997 May; 124(10):2075-85. PMID: 9169853.
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      59. Maroto M, Reshef R, Münsterberg AE, Koester S, Goulding M, Lassar AB. Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue. Cell. 1997 Apr 4; 89(1):139-48. PMID: 9094722.
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      60. Daston G, Lamar E, Olivier M, Goulding M. Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse. Development. 1996 Mar; 122(3):1017-27. PMID: 8631247.
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      61. Bang AG, Goulding M. Regulation of vertebrate neural cell fate by transcription factors. Curr Opin Neurobiol. 1996 Feb; 6(1):25-32. PMID: 8794048.
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      62. Kilpatrick TJ, Brown A, Lai C, Gassmann M, Goulding M, Lemke G. Expression of the Tyro4/Mek4/Cek4 gene specifically marks a subset of embryonic motor neurons and their muscle targets. Mol Cell Neurosci. 1996 Jan; 7(1):62-74. PMID: 8812059.
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      63. Chalepakis G, Goulding M, Read A, Strachan T, Gruss P. Molecular basis of splotch and Waardenburg Pax-3 mutations. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3685-9. PMID: 7909605.
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      64. Goulding M, Lumsden A, Paquette AJ. Regulation of Pax-3 expression in the dermomyotome and its role in muscle development. Development. 1994 Apr; 120(4):957-71. PMID: 7600971.
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      65. Goulding M, Paquette A. Pax genes and neural tube defects in the mouse. Ciba Found Symp. 1994; 181:103-13; discussion 113-7. PMID: 7911756.
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      66. Goulding M, Sterrer S, Fleming J, Balling R, Nadeau J, Moore KJ, Brown SD, Steel KP, Gruss P. Analysis of the Pax-3 gene in the mouse mutant splotch. Genomics. 1993 Aug; 17(2):355-63. PMID: 8406486.
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      67. Goulding M, Lumsden A, Gruss P. Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord. Development. 1993 Mar; 117(3):1001-16. PMID: 8100762.
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      68. Chowdhury K, Goulding M, Walther C, Imai K, Fickenscher H. The ubiquitous transactivator Zfp-38 is upregulated during spermatogenesis with differential transcription. Mech Dev. 1992 Dec; 39(3):129-42. PMID: 1284028.
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      69. Walther C, Guenet JL, Simon D, Deutsch U, Jostes B, Goulding M, Plachov D, Balling R, Gruss P. Pax: a murine multigene family of paired box-containing genes. Genomics. 1991 Oct; 11(2):424-34. PMID: 1685142.
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      70. Chalepakis G, Fritsch R, Fickenscher H, Deutsch U, Goulding M, Gruss P. The molecular basis of the undulated/Pax-1 mutation. Cell. 1991 Sep 6; 66(5):873-84. PMID: 1889089.
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      71. Goulding M, Chalepakis G, Deutsch U, Erselius JR, Gruss P. Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J. 1991 May; 10(5):1135-47. PMID: 2022185.
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      72. Erselius JR, Goulding M, Gruss P. Structure and expression pattern of the murine Hox-3.2 gene. Development. 1990 Oct; 110(2):629-42. PMID: 1723949.
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      73. Hatzopoulos AK, Stoykova AS, Erselius JR, Goulding M, Neuman T, Gruss P. Structure and expression of the mouse Oct2a and Oct2b, two differentially spliced products of the same gene. Development. 1990 Jun; 109(2):349-62. PMID: 1976089.
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